TIMP1 Polyclonal Antibody Gene Summary: This Gene Belongs to the TIMP Gene Family

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TIMP1 polyclonal antibody Gene Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are Catalog Number: PAB19116 natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation Regulatory Status: For research use only (RUO) of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is Product Description: Rabbit polyclonal antibody raised able to promote cell proliferation in a wide range of cell against synthetic peptide of TIMP1. types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response Immunogen: A synthetic peptide corresponding to to many cytokines and hormones. In addition, the C-terminus of human TIMP1. expression from some but not all inactive X chromosomes suggests that this gene inactivation is Host: Rabbit polymorphic in human females. This gene is located Reactivity: Human within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq] Applications: IHC-P, WB-Re (See our web site product page for detailed applications information) Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Form: Lyophilized Purification: Immunoaffinity purification Isotype: IgG Recommend Usage: Western Blot (1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL) The optimal working dilution should be determined by the end user. Storage Buffer: Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal) Storage Instruction: Store at -20°C on dry atmosphere. After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 7076 Gene Symbol: TIMP1 Gene Alias: CLGI, EPA, EPO, FLJ90373, HCI, TIMP Page 1/1 Powered by TCPDF (www.tcpdf.org).

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Negative Regulation of TIMP1 Is Mediated by Transcription Factor TWIST1
181-186.qxd 29/5/2009 01:25 ÌÌ ™ÂÏ›‰·181 INTERNATIONAL JOURNAL OF ONCOLOGY 35: 181-186, 2009 181 Negative regulation of TIMP1 is mediated by transcription factor TWIST1 HIROHIKO OKAMURA1, KAYA YOSHIDA2 and TATSUJI HANEJI1 Departments of 1Histology and Oral Histology and 2Fundamental Oral Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan Received January 13, 2009; Accepted March 27, 2009 DOI: 10.3892/ijo_00000327 Abstract. TWIST1 is involved in tumor invasion and meta- process was mediated through suppression of the ARF/ stasis by promoting epithelial-to-mesenchymal transition. MDM2/p53 pathway (6). It was also reported that amplification However, the molecular target of TWIST1 involving this of Twist1 gene was associated with the development of mechanism is poorly understood. To identify the TWIST1- acquired resistance to anticancer drugs and ectopic expression regulated genes, we established the Saos-2 cells stably of Twist1 gene leads to resistance to microtubule disrupting expressing TWIST1 gene by transfecting TWIST1 cDNA into agents (7). TWIST1 is shown to affect AKT to mediate taxol the cells and performed a differential display approach by resistance in nasopharyngeal carcinoma cells and up- using annealing control primers. Here, we report that one of regulation of AKT2 by TWIST1 promoted cell survival, the genes that were down-regulated in TWIST1 expressing migration and invasion in breast cancer cells (8,9). The cells is predicted to be TIMP1. TIMP1 has been reported as increased expression of TWIST1 has been commonly used as the naturally occurring specific inhibitor of matrix metallo- molecular marker for EMT (10).
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Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels
Molecular Pharmacology Fast Forward. Published on August 10, 2017 as DOI: 10.1124/mol.117.109397 This article has not been copyedited and formatted. The final version may differ from this version. MOL #109397 Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3). Anastasios Chanalaris, Christine Doherty, Brian D. Marsden, Gabriel Bambridge, Stephen P. Wren, Hideaki Nagase, Linda Troeberg Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Downloaded from Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK (A.C., C.D., G.B., H.N., L.T.); Alzheimer’s Research UK Oxford Drug Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK (S.P.W.); Structural Genomics Consortium, molpharm.aspetjournals.org University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7DQ (BDM). at ASPET Journals on September 29, 2021 1 Molecular Pharmacology Fast Forward. Published on August 10, 2017 as DOI: 10.1124/mol.117.109397 This article has not been copyedited and formatted. The final version may differ from this version. MOL #109397 Running title: Repurposing suramin to inhibit osteoarthritic cartilage loss. Corresponding author: Linda Troeberg Address: Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK Phone number: +44 (0)1865 612600 E-mail: [email protected] Downloaded
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Investigation of COVID-19 Comorbidities Reveals Genes and Pathways Coincident with the SARS-Cov-2 Viral Disease
bioRxiv preprint doi: https://doi.org/10.1101/2020.09.21.306720; this version posted September 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. Title: Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease. Authors: Mary E. Dolan1*,2, David P. Hill1,2, Gaurab Mukherjee2, Monica S. McAndrews2, Elissa J. Chesler2, Judith A. Blake2 1 These authors contributed equally and should be considered co-first authors * Corresponding author [email protected] 2 The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA Abstract: The emergence of the SARS-CoV-2 virus and subsequent COVID-19 pandemic initiated intense research into the mechanisms of action for this virus. It was quickly noted that COVID-19 presents more seriously in conjunction with other human disease conditions such as hypertension, diabetes, and lung diseases. We conducted a bioinformatics analysis of COVID-19 comorbidity-associated gene sets, identifying genes and pathways shared among the comorbidities, and evaluated current knowledge about these genes and pathways as related to current information about SARS-CoV-2 infection. We performed our analysis using GeneWeaver (GW), Reactome, and several biomedical ontologies to represent and compare common COVID- 19 comorbidities. Phenotypic analysis of shared genes revealed significant enrichment for immune system phenotypes and for cardiovascular-related phenotypes, which might point to alleles and phenotypes in mouse models that could be evaluated for clues to COVID-19 severity.
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Identification of Gene Expression and DNA Methylation of SERPINA5 and TIMP1 As Novel Prognostic Markers in Lower-Grade Gliomas
Identification of gene expression and DNA methylation of SERPINA5 and TIMP1 as novel prognostic markers in lower-grade gliomas Wen-Jing Zeng1,2,3,4, Yong-Long Yang5, Zhi-Peng Wen1,2, Peng Chen1,2, Xiao-Ping Chen1,2 and Zhi-Cheng Gong3,4 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China 2 Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China 3 Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China 4 National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, Hunan, China 5 Department of Clinical Pharmacology Research Center, Changsha Carnation Geriatrics Hospital, Changsha, Hunan, China ABSTRACT Background. Lower-grade gliomas (LGGs) is characteristic with great difference in prognosis. Due to limited prognostic biomarkers, it is urgent to identify more molecular markers to provide a more objective and accurate tumor classification system for LGGs. Methods. In the current study, we performed an integrated analysis of gene expression data and genome-wide methylation data to determine novel prognostic genes and methylation sites in LGGs. Results. To determine genes that differentially expressed between 44 short-term survivors (<2 years) and 48 long-term survivors (≥2 years), we searched LGGs TCGA RNA-seq dataset and identified 106 differentially expressed genes. SERPINA5 and Submitted 11 October 2019 Accepted 9 May 2020 TIMP1 were selected for further study. Kaplan–Meier plots showed that SERPINA5 Published 3 June 2020 and TIMP1 expression were significantly correlated with overall survival (OS) and Corresponding authors relapse-free survival (RFS) in TCGA LGGs patients.
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Anti-TIMP1 Antibody [2A5] (ARG10543)
Product datasheet [email protected] ARG10543 Package: 100 μg anti-TIMP1 antibody [2A5] Store at: -20°C Summary Product Description Mouse Monoclonal antibody [2A5] recognizes TIMP1 Tested Reactivity Hu Tested Application IHC-P, WB Host Mouse Clonality Monoclonal Clone 2A5 Isotype IgG1, kappa Target Name TIMP1 Antigen Species Human Immunogen Ovalbumin-conjugated synthetic peptide. (FQALGDAADIR) Conjugation Un-conjugated Alternate Names Erythroid-potentiating activity; TIMP; Collagenase inhibitor; Fibroblast collagenase inhibitor; TIMP-1; EPO; CLGI; Tissue inhibitor of metalloproteinases 1; HCI; Metalloproteinase inhibitor 1; EPA Application Instructions Application table Application Dilution IHC-P 1:8 WB 1:5 Application Note IHC-P: Antigen Retrieval: Microwave for 7 min at 950W in 0.01 M Sodium citrate buffer (pH 6.0) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. Positive Control IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma. Western blot: rhTIMP-1, 400 ng per lane. Calculated Mw 23 kDa Properties Form Liquid Purification Affinity purification with immunogen. Buffer PBS and 0.02% Sodium azide Preservative 0.02% Sodium azide Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed www.arigobio.com 1/3 before use. Note For laboratory research only, not for drug, diagnostic or other use. Bioinformation Database links GeneID: 7076 Human Swiss-port # P01033 Human Gene Symbol TIMP1 Gene Full Name TIMP metallopeptidase inhibitor 1 Background This gene belongs to the TIMP gene family.
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Prognostic Significance of TIMP-1 in Non-Small Cell Lung Cancer
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