International Veterinary Epilepsy Task Force's Current Understanding Of
Hülsmeyer et al. BMC Veterinary Research (2015) 11:175 DOI 10.1186/s12917-015-0463-0 CORRESPONDENCE Open Access International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs Velia-Isabel Hülsmeyer1*, Andrea Fischer1, Paul J.J. Mandigers2, Luisa DeRisio3, Mette Berendt4, Clare Rusbridge5,6, Sofie F.M. Bhatti7, Akos Pakozdy8, Edward E. Patterson9, Simon Platt10, Rowena M.A. Packer11 and Holger A. Volk11 Abstract Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted. Keywords: Idiopathic epilepsy, Dog, Breed, Epilepsy prevalence, Epileptic seizure Introduction in part underlying genetic backgrounds (see also Tables 1 Canine idiopathic epilepsy is a common neurological and 2) [5, 6].
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