For Research Use Only. Not for use in diagnostic procedures. Rev: 06/24/2020

PathPlusTM Polyclonal Rabbit anti‑Human P2RY1 / P2Y1 Antibody (C‑Terminus, IHC)

Antibody: Rabbit Polyclonal to Human P2RY1 / P2Y1 Application: IHC, IHC-P, ELISA Reactivity: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit Format: Unconjugated, Unmodified Catalog Number: MC-389 Product Size: 50 µg Concentration: 1 mg/ml

Description: Purinergic P2Y, G- coupled, 1 (P2RY1) has several receptor subtypes with different pharmacological selectivity for various and . P2RY1 functions as a receptor for extracellular ATP and ADP. In , binding to ADP leads to mobilization of intracellular ions via activation of phospholipase C, a change in shape, and probably to platelet aggregation.

Target: Human P2RY1 / P2Y1 Synonyms: P2RY1 | ATP receptor | p2Y1 | p2y1r | Platelet ADP receptor | Purinoceptor p2y1 | | p2 purinoceptor subtype Y1 | p2RY1 | p2Y purinoceptor 1 | p2y-1-r | Purinoceptor p2yr1 | p2y1 receptor Host: Rabbit Reactivity: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit (tested or 100% immunogen sequence identity) Predicted: Chicken, Xenopus (at least 90% immunogen sequence identity) Clonality: Polyclonal Conjugations: Unconjugated Purification: Immunoaffinity purified Modifications: Unmodified Applications: IHC IHC - Paraffin (6 µg/ml) ELISA

Immunogen: Synthetic 19 amino acid peptide from C-Terminus of human P2RY1 / P2Y1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Bat, Dog, Bovine, Horse, Rabbit, Opossum, Guinea pig, Lizard (100%); Panda, Turkey, Chicken, Platypus, Xenopus (95%). Epitope: C-Terminus Specificity: Human P2RY1 / P2Y1. BLAST analysis of the peptide immunogen showed no homology with other human . Presentation: PBS, 0.1% Sodium Azide Storage: Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.

Anti -P2RY1 / P2Y1 antibody IHC of Brain, cortex, neurons Brain, Hypothalamus human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat- induced antigen retrieval.

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