HST and Other Approved Grants PAGE 1 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST D ii A. C. Nielsen Amer (Shj. Br.) Global State of Poll 2019 Survey on usage patterns and An in-depth understanding of which mindsets exist across Qualitative and quantitative country May-19 Oct-19 perceptions regarding countries with regards to the triggers and barriers to reports, results dashboard, and products and ANDSs among adults quitting smoking or switching to less harmful alternatives. methodology statement (including across seven countries. Expected outcomes include production and dissemination questionnaire). of 2019 Global Poll Results.

HST+ A ii AF Development Care LLP Alternative livelihood Options for Women Alternative-livelihood options for An in-depth understanding of alternative-livelihood options Policy analysis report prepared and Mar-20 Aug-20 Bidi Rollers- Primary Research and Policy women who work as bidi rollers. for bidi workers in two major bidi-producing states in . shared with policymakers. Other Mapping of home-based Women bidi rollers Review of existing work, policy Expected outcomes include a policy analysis report, a study deliverables also in progress. of Tamil Nadu and Karnataka mapping and primary research of report, two published articles, and a phase-two project home-based women in the Indian bidi proposal industry.

HST A,B i,iii Agenome LLC Cancer risk in Smoking Subjects Assessed by Assess cancer risk in smoking subjects The endpoints of the research proposal are to develop a Deliverable will be available at the end Feb-19 May-21 Next Generation Sequencing profiling of through NGS profiling of freely numeric score associated with cancer risk, and to of grant. Work in progress. Preprint on circulating free DNA and RNA circulating DNA and RNA. Create a demonstrate the reversibility of smoke-induced genetic bioRXIV: genome database representative of alterations. https://www.biorxiv.org/content/ non-smoking populations to identify 10.1101/2020.06.05.124891v1. new genes that predispose individuals to cancer.

HST A i Alternative Research Initiative Mapping the status of Map the status of harm-reduction Improved understanding of barriers to and opportunities Status report, "Mapping of Harm May-18 Aug-18 products in Pakistan products for cessation and THR in for or switching to safer products in Reduction Products in Pakistan". Pakistan Pakistan. Available at: http://www.panthr.org/ publications/Mapping-of-Harm- Reduction-Products-in-Pakistan.pdf.

HST A i Alternative Research Initiative Continuation of work on mapping the status To further assess the status of harm- Assessment included in long-term proposal submitted to Proposal developed and submitted to Oct-18 Dec-18 of harm reduction products in Pakistan reduction approaches in Pakistan. FSFW. FSFW.

HST A i Alternative Research Initiative Barriers to smoking cessation and harm Study on barriers to smoking cessation A deeper understanding of the profile, perceptions, and Two study reports, "Barriers to Dec-18 Dec-19 reduction in marginalized communities and reduced-risk products in needs of smokers living in marginalized communities in Smoking Cessation in Marginalized marginalized communities in Pakistan. Pakistan with a view to ending smoking Communities and the Use of Harm Reduction Products in Islamabad, Pakistan" and "KAP Study on Vapers in Pakistan." Available at http:// www.panthr.org/publications/.

HST+ A i Alternative Research Initiative COP9 - Increasing Awareness Establish an alliance secretariat for a Garner consensus and support for the ninth Conference of Deliverable will be available at the end Feb-20 Dec-20 regional network in the EMRO region the Parties to the WHO Framework Convention on Tobacco of grant. Work in progress. ahead of COP9. Control (COP9) to consider harm reduction as integral to .

HST+ A i,ii American Masala 51 Shades of Smokey Grey Multi-country investigation to Documentation and understanding of how tobacco as a Deliverable will be available at the end Jan-20 Jul-20 determine how tobacco interfaces crop and commodity interfaces with everyday life across of grant. Work in progress. with daily life and society across four four tobacco-growing countries countries.

HST A i,iii Anaytisch-Biologisches Phase 1 Biomarker Research Scoping work for research concerning A full phase-two study proposal outlining methods to Full proposal for future work (phase Oct-18 Jan-19 Forschungslabor Gmbh biomarkers of product identify the biomarkers of the exposome, adductome, and two) submitted to FSFW. exposure. breathome that can also distinguish between different groups of those who use nicotine products.

HST A i,iii Anaytisch-Biologisches Phase 2 Biomarker research: conduct the Identify biomarkers that distinguish Systematic review plus clinical study report on the Deliverable will be available at the end Feb-19 Feb-21 Forschungslabor Gmbh literature review, clinical study, and analysis between nicotine product use groups. identified biomarkers of nicotine product exposure. of grant. Work in progress. of collected samples to identify meaningful biomarkers that properly distinguish between nicotine product use groups

HST A i,ii Asia Management Private A Survey of Smoking Behavior of Young Survey of the smoking behavior of Better understanding of youth knowledge, attitudes, and Detailed survey report delivered to Sep-19 Mar-20 Limited Adults in Maldives young adults development of two-year practices concerning smoking. Analyzing drivers of use and FSFW. plan of action for ending youth uptake, facilitating knowledge development, and smoking in the Maldives. encouraging exchange and consensus building between stakeholders with an overarching aim to laying the foundation for stronger, evidence-based policies geared to discourage youths from smoking. HST and Other Approved Grants PAGE 2 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST+ A,D i,ii Asia Public History Foundation Smoky Horizons: Tobacco and Empire in Asia Explore historical routes of tobacco Better understanding and documentation of how the British Academic report delivered to FSFW. Dec-18 Aug-19 Inc (1850-1950) production, circulation, and Empire drove and continues to perpetuate tobacco addition in Asia and China as well as policy- in Asia, plus recommendations for ways to move forward. related solutions.

HST+ A i,ii Asociación Argentina De COP9 - Increasing Awareness Awareness raising in the lead up to Garner consensus and support for the ninth session of Deliverable will be available at the end Mar-20 Jan-21 Servicios Y Estudios Médicos De COP9. Conference of the Parties to the WHO Framework of grant. Work in progress. Avanzada Convention on Tobacco Control (COP9) to consider harm reduction as integral to tobacco control.

HST A i,iii Behavioral Diagnostics, LLC Biomarker research program Scoping work for research concerning Scoping work for development of future grant proposal. Full proposal for future work Oct-18 Jan-19 biomarkers indicating nicotine submitted to FSFW. product exposure.

HST A i,iii Behavioral Diagnostics, LLC An Integrated Epigenetic ELISA Saliva Kit for Development of a kit for the detection Development of a saliva test kit to categorize groups of Deliverable will be available at the end Feb-19 Feb-21 Detecting & Quantifying the Use of Tobacco and quantification of tobacco and individuals using nicotine products (output) that could be of grant. Work in progress. and Nicotine Products other nicotine product use. used in future research and efforts to help guide approaches to cessation therapy.

HST+ A,D i,iii Biochromex Nicotine product relative risk assessment Nicotine product relative risk Produce a relative risk assessment of nicotine products Final deliverable being reviewed and Jan-20 Jun-20 assessment. based on assembled data from the scientific literature. under discussion before finalizing. Understand the level of evidence currently available regarding the health risks of nicotine products.

HST A,D i,ii BOTEC Analysis, LLC A Multi-disciplinary Investigation into the Investigate the drivers for smoking Substantial contribution to the debate about how ANDS fit Deliverable will be available at the end Jul-19 Sep-20 Drivers for Smoking Cessation in Five cessation in five countries with ANDS into the goal of reducing smoking harm by providing a of grant. Work in progress. Countries with ANDS Markets markets. comprehensive understanding of cessation drivers in selected target countries, with a view to informing and focusing regulations to promote smoking cessation.

HST A,B,D i,ii,iii Cambridge Design Partnership Emerging technologies to drive mass Scoping work to identify opportunities Proposal for a grant laying the foundations for future work. Full proposal delivered to FSFW. May-18 Aug-18 Ltd adoption of reduced-risk products to develop and deploy emerging technologies to end smoking in LMICs.

HST A,B,D i,ii,iii Cambridge Design Partnership Looking to the future: Emerging innovations Investigate impediments to RRP In-depth understanding of the impediments to RRP uptake Final report delivered to FSFW. Apr-19 Feb-20 Ltd to end smoking: Phase 2 Addressing the adoption for cessation and THR in in four LMICs (India, Indonesia, Russia, and China) plus one Manuscript in development. impediments to mass adoption of RRP in LMICs. HIC (United Kingdom) via qualitative and quantitative LMIC research with a view to supporting an end to smoking.

HST+ D i,vii Carlyle Global Partners LLC Co-host summit celebration of knowledge & Co-host summit celebrating Summit organized. Summit completed. Nov-17 Mar-18 innovation at the nexus of wellness & smoke knowledge and innovation at the free world nexus of wellness and a smoke-free world.

HST+ D i,vii Carlyle Global Partners LLC Co-Host "A Celebration of Knowledge and Co-host summit celebrating Summit organized. Summit (program available, "A Jul-18 Sep-18 Innovation at the Nexus of Wellness and a knowledge and innovation at the Celebration of Philanthropy and Smoke-Free World." nexus of wellness and a smoke-free Innovation Transforming Health and world. Wellness") completed.

HST B,D i,ii,iii Centre For Health Research And Smoke-Free UK- identifying and addressing Smoke-free UK landscaping project, Development of insights on individuals who smoke in the Deliverable being reviewed. Nov-19 Jun-20 Education Limited, UK the needs of the remaining hard core of reaching the 'hardcore' of smokers UK, and their healthcare advisers' needs and wants to help smokers and their influencers and supporting quitting. achieve smoking cessation. Identification of priority interventions needed to maximize smoking cessation in the UK. Expected outputs include publicly available study report and data (print and web form).

HST B,D i,ii,iii,vii Centre For Health Research And Working towards achieving and sustaining Achieve and sustain smoke-free Development of a protocol for smoking cessation in mental- Deliverable will be available at the end Nov-19 Nov-20 Education Limited, UK smoke-free at UK's Priory Group Mental environment at UK's Priory Group health facilities that could be adapted globally in future of grant. Work in progress. Health Hospitals Mental Health Hospitals. projects; building confidence among key stakeholders in the Priory Group to be able to go smoke free in a sustainable way; and delivery of an online e-learning course available for rollout across Priory. This bespoke training will allow Priory staff to stay updated on smoking cessation.

HST B,D i,ii,vii Centre For Health Research And Evaluating the feasibility and establishment Scoping work for the establishment of Development of a coherent and bold vision for a multi- Deliverable will be available at the end Jan-20 Jul-20 Education Limited, UK of a multi-center network for tobacco a multi-center network for tobacco center network detailed in a proposal to FSFW for a multi- of grant. Work in progress. research and cessation in India research and cessation in India. year programme grant. HST and Other Approved Grants PAGE 3 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST B i Centre For Substance Use Proposal to develop a Centre of Excellence in Scoping work for the establishment of Scoping work for development of future grant proposal. Scoping work for development of May-18 Aug-18 Research Behavioral Research Related to ANDS and a Centre of Excellence in Behavioral future grant proposal submitted to Smoking Cessation Research Related to ANDS and FSFW. Smoking Cessation.

HST B i Centre For Substance Use Determinants and impacts of switching to Scoping work for development and Replication of research undertaken in HICs and building the Narrative report including full May-18 Aug-18 Research reduced risk products (RRPs) implementation of replication knowledge base on successful interventions, with a view proposal for future work delivered to research on determinants of use and towards supporting smoking cessation and/or switching to FSFW. impacts of RRPs in LMICs. safer alternatives in LMICs.

HST A,B,D i,ii,iii Centre of Research Excellence Proposal to build a global center for smoking Scoping work for establishment of a Groundwork for establishment and operationalization of COE established; multiple publicly May-18 Jun-19 On Indigenous Sovereignty & cessation and harm reduction in indigenous Global Centre for Smoking Cessation COREISS. available outputs generated. Smoking, The people and Harm Reduction in Indigenous People.

HST A,B,D i,ii,iii Centre Of Research Excellence Bridging grant To retain staff and experts. Staff retained and available for work on long-term proposal. Staff retained and available for next May-19 Aug-19 On Indigenous Sovereignty & grant. Smoking, The

HST A,B,D i,ii,iii Centre Of Research Excellence Centre of Research Excellence: Indigenous Center of Excellence focusing on Advancement of knowledge on global indigenous tobacco Multiple publicly available outputs Jul-19 Aug-24 On Indigenous Sovereignty & Sovereignty & Smoking – Center Grant tobacco use, tobacco-harm reduction use and how to more rapidly reduce smoking among generated; more in progress. Smoking, The and capacity building among indigenous people; of addiction theory, behavior change indigenous communities worldwide. and harm reduction; and of contributions to advancing knowledge on public-health ethics. This project further seeks to fortify responses in indigenous communities in response to harmful consequences of .

HST A i Child Sight Foundation Systematic review and situation analysis of Investigate current landscape of Development of knowledge base, including sharing of Final study report submitted to FSFW. May-18 Sep-18 smoking and perceptions about harm tobacco smoking and knowledge results with relevant stakeholders including research reduction amongst slum dwellers in Dhaka among slum dwellers in Dhaka, funders in Nepal. City Bangladesh.

HST+ A i,ii Child Sight Foundation Economics of cessation and THR in South Economics of cessation and THR in This project is comprised of four stages: data collection and Deliverable will be available at the end Mar-20 Sep-20 Asia: A Scoping Study and Situation Analysis South Asia: A Scoping Study and literature review to earmark existing knowledge base, data of grant. Work in progress. Situation Analysis. analysis to identify research gaps and consistent policy gaps, existing policy analysis and its gap to underline the potential gain from harm-reduction policy, furnishing an extensive research proposal for mitigating data, literature and policy gaps.

HST A i Clinivantage Healthcare Rural and urban-slum patterns of tobacco To investigate how geographical To generate locally applicable knowledge that can assist Full proposal submitted to FSFW. May-18 Aug-18 Technologies, Inc cessation and use setting influences patterns of tobacco healthcare individuals, local policymakers, local village cessation and use in rural and urban groups and local organizations make decisions regarding slum communities in India. the provision of cessation services and reduced risk products.

HST+ B i,ii,vii COHRED USA - Council On Strengthening national research system Development of a long-term proposal Long-term proposal including plan for strengthening Deliverable will be available at the end Jan-20 Sep-20 Health Research For capacity in Low- and Middle-Income for "Strengthening national research national research system capacity in LMICs. of grant. Work in progress. Development countries in support of tobacco control, system capacity in low- and middle- health, equity and development. income countries in support of Brief Title: NRS for FCTC20-21-22 tobacco control, health, equity and development."

HST+ B vii Conrad Foundation Two-year core funding to continue Conrad Sponsorship of the 2019-2020 and Development of a network of representatives within and Deliverable will be available at the end Jul-19 May-21 Challenge. 2020-2021 CONRAD spirit of outside the United States, participation and engagement in of grant. Work in progress. innovation challenge. the FSFW special category.

HST+ B vii Conrad Foundation Conrad Challenge winners 2019 Support CONRAD Challenge . Development of a network of representatives within and Final report submitted to FSFW. Being May-20 Jun-20 outside the United States, participation and engagement in reviewed. the FSFW special category. HST and Other Approved Grants PAGE 4 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST+ A i,ii Cornell University An Economic Study of Risk Perceptions and Economic study of risk perceptions Determination of whether the information shock created by Deliverable will be available at the end Jan-20 Jan-21 Consumer Demand for Harm Reduction and consumer demand for harm- the EVALI outbreak had important impacts in tobacco of grant. Work in progress. Products reduction products. product markets. Project results will be made publicly available via presentation at academic conferences, and one or more manuscripts will be prepared for submission to highly visible, peer-reviewed academic journals. Based on the importance of the research questions and the research team’s publication record, it is expected that the findings will be influential in policy.

HST+ A i,ii Cornell University Economic Analysis of Harm Reduction, Development of a report to aid Long-term proposal to explore the chemical signature of e- Deliverable will be available at the end May-20 Feb-21 Hyperbolic Discounting, and Menthol development of long-term proposal. residues in a house-like environment. The of grant. Work in progress. proposal is also intended to outline a lab assessment of the effects of exposure to vaping on lung cells.

HST A i,ii Drexel University Study the impacts of e-cigarette and tobacco Scoping work for research to Development of a testing platform for laboratory Full proposal for future work Dec-18 Oct-19 smoke residue investigate impacts of residual investigations of e-cigarette residue to complement the submitted to FSFW. tobacco smoke and e-cigarette residue testing of combustible previously worked residue. on.

HST A,B i,ii,iii ECLAT SRL Center of Excellence for the Acceleration of Scoping work for establishment of a Groundwork for successful operationalization of CoEHAR. The acceleration of the development May-18 Aug-18 Harm Reduction (CoEHAR) CoE for the acceleration of harm of the CoEHAR achieved successfully. reduction. Agreements with strategic partners signed.

HST A,B i,ii,iii ECLAT SRL Accelerate and improve smoking precision Accelerate and improve smoking Development of a long-term proposal. Full proposal submitted to FSFW and Sep-18 Nov-18 and detection rate of monitoring the precision and detection rate of considered along with main CoE smoking episodes by using the SmokeBeat monitoring the smoking episodes via proposal. Technology SmokeBeat technology.

HST A,B i,ii,iii ECLAT SRL Multi-country longitudinal study of the Preparation for a long-term study A replicated, improved version of the EU PATH study. RFP published online; draf report on Feb-19 Jul-19 tobacco/nicotine usage patterns and their based on EU PATH study. innovative technologies to gather data impact on health in Europe: RFP preparation from people in survey studies; revised for the replication of EU-PATH study. EU PATH proposal.

HST A,B i,ii,iii ECLAT SRL Center of Excellence for the Acceleration of Establishment of a CoE to undertake Delivery of Summer School on Projects Management, Multiple publicly available outputs Feb-19 Mar-24 Harm Reduction (CoEHAR) work on Summer School on Projects research projects planned and launched to expand generated; delivery of 2019 Summer Management, expand knowledge on knowledge on tobacco harm reduction and health. School. tobacco harm reduction and health, replicate previous laboratory findings, and develop technical innovations to support studies.

HST A,B i,ii,iii ECLAT SRL Guidelines and Framework for the Quality of Develop guidelines for quality One scientific article detailing the problems and flaws with Final deliverables (articles and a white Jul-19 May-20 Tobacco/Nicotine product research tobacco/nicotine product research. a large number of current research articles in the field. An paper) currently in progress to overview of what a good study design for tobacco control incorporate feedback. research should incorporate. One white paper to be published, together with a set of guidelines and framework. The advisory review board will issue a consensus statement which will be disseminated by the investigators.

HST A,B i,ii,iii,vii ECLAT SRL Catania Conversation: a multi-pronged Bridge the gaps and build Development of capacity and integrity around THR science Final report will be available at the Nov-19 Sep-20 initiative to fill the gaps in communication accountability in media and policy media reporting. end of grant. Work in progress. around tobacco harm reduction communications around THR science.

HST+ A i,ii Economic Policy Research Economic analysis of tobacco, tobacco Economic analysis of tobacco, tobacco To strengthen research capacity and devise policies aimed Deliverable being discussed and under Jan-20 Jun-20 Foundation Of Turkey (TEPAV) products, and their alternatives in Turkey products, and their alternatives in at reducing the health hazards and costs related to tobacco, review. and the Turkish Republic of Northern Turkey and the Turkish Republic of tobacco products, and their alternatives. Proposal for future Cyprus. Northern Cyprus. work.

HST A,C i Embera Neuro Therapeutics Manufacturing EMB-001 Clinical Trial Tobacco use disorder clinical study. To manufacture, package, label, and release EMB-001 Deliverable will be available at the end Aug-19 Sep-20 Material for the Phase 2a Tobacco Use clinical trial material (CTM) for use in the EMB-001 Phase 2a of grant. Work in progress. Disorder (TUD) clinical study to be TUD clinical trial. conducted at the Rose Research Center (RRC) under the RRC’s Center Grant from the FSFW. HST and Other Approved Grants PAGE 5 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST C i Ernst & Young Ag Lessons from countries with ANDS Synthesize and formulate lessons Identification and understanding of appropriate measures Final reports being discussed and Jul-19 Mar-20 availability which have seen drastic drops in learned from countries with ANDS to reduce smoking in a different sections of the smoking under review. number of smokers availability who have undergone population. drastic reductions in the number of individuals who smoke.

HST C i Ernst & Young Ag Determinants of a smoker characterization Identification of observable smoker Identification of select characteristics with evidence of Final reports being discussed and Jul-19 Mar-20 tool characteristics that are linked to predicting success for smoking cessation, as well as to under review. cessation success. disprove an equal amount.

HST A i,iii Etheim Biotics, LLC Smoking Dysbiosis and Restorative Methods: Multi-regional study to examine the A deeper understanding of the impacts of smoking and Deliverable will be available at the end Feb-19 Feb-24 Probiotic approaches to restore the human impact of smoking and vaping on the vaping on the human microbiome, and potential solutions of grant. Work in progress. microbiome in those who have recently quit human microbiome. to mitigate any negative impacts so that users will cigarette smoking. experience better short- and long-term health outcomes

Industry A iv Euromonitor International Inc Tobacco Transformation Index Euromonitor International is First Tobacco Transformation Index scheduled to launch Project status available at https:// Feb-19 Nov-22 transforma responsible for index process design, September 2020. tobaccotransformationindex.org/. tion research and analysis, and reporting. HST+ A i,ii Euromonitor International Inc EU Menthol Ban Impact Analysis EU menthol ban impact analysis. Conduct a series of surveys analyzing the behaviors of adult Pre-ban survey and analysis available. Mar-20 Dec-20 smokers in several EU countries before and afer the ban in May 2020. Industry D i Feng Insight China policy landscape and related high- Conduct China policy landscape Political review and set of recommendations for future Set of recommendations presented to Jun-19 Nov-19 transforma level strategic review of FSFW engagement, analysis and related high-level FSFW work. FSFW. tion including recommendations. strategic review. HST B,C i Fox Foundation Center to promote healthy behavioral Establishment of a global research Scoping work to inform the development of a five-year Proposal submitted to FSFW. Dec-18 Jan-19 change program to develop, evaluate, and research center. disseminate consumer-driven approaches to improve the effectiveness of smoking cessation and harm-reduction interventions.

HST+ D i,vii FP Group Sponsorship of Her Power Summit Research and promotion of women’s Introduction of THR in gender-equality discussions. Deliverable will be available at the end Mar-20 Sep-20 rights and gender equality via the of grant. Work in progress. “Women as Levers of Change” project. HST+ A i,ii Healthy Initiatives Economics of ending smoking epidemic by Evaluate the status and the gaps in TC Documentation of TC status gaps across multiple countries Deliverable will be available at the end Jan-20 Jul-20 evaluating the status and the gaps in existing policies in Ukraine, the Russian with a view to supporting an end to smoking and laying of grant. Work in progress. TC policies in Ukraine, the Russian Federation, and a number of groundwork for the development of a comprehensive study Federation and number of developing developing former USSR countries in proposal. Former Soviet countries in East and Central the East and Central Asia (ECA) region. Asia (ECA) region.

HST+ A,B i,ii,vii International Network Of Strengthening nicotine consumer Strengthening safer nicotine Development of organizational structure and solid business Organizational structure in place. Nov-18 Jul-19 Nicotine Consumer organizations consumer voices. plan with input from all members and associates. Three-year business plan submitted to Organisations FSFW as part of a long-term application.

HST+ A,B i,ii,vii International Network Of Development of a business plan to Development of business plan for Strengthening of business plan. Business plan delivered to FSFW and Oct-19 Jul-20 Nicotine Consumer strengthen nicotine consumer organizations INNCO, which aims to "represent forms part of long term grant Organisations network consumers of low-risk, alternative approved by FSFW board. nicotine products and to promote tobacco harm reduction on the global stage."

HST+ A,B i,ii,vii International Network Of COP9 and NCDs Support partnering and learning Garner consensus and support for COP9 to consider harm Deliverable will be available at the end Jan-20 Jul-20 Nicotine Consumer among representatives of THR reduction as integral to tobacco control. of grant. Work in progress. Organisations nicotine users and drug harm reduction non-profits.

HST+ A,B i,ii,vii International Network Of Strengthen and build capacity for Tobacco To strengthen and build capacity for To strengthen and build capacity for THR as a tool to reduce Deliverable will be available at the end May-20 Jun-21 Nicotine Consumer Harm Reduction as a tool to reduce THR as a tool to reduce incidence of incidence of smoking. of grant. Work in progress. Organisations incidence of smoking. smoking. HST+ A i Just Managing Consulting Public Health and Government Investment To provide empirical data about the Contribution to ongoing discussions about the role of Report delivered and being reviewed Jan-20 Mar-20 in Tobacco - Phase I state of government ownership in governments in tobacco control. by FSFW. tobacco companies. HST and Other Approved Grants PAGE 6 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST+ A i Just Managing Consulting Public Health and Government Investment To undertake in-depth analysis of Based on potential conflicts of interests associated with Deliverable will be available at the end Mar-20 Sep-20 in Tobacco - Phase II areas identified in phase-one report. state ownership of tobacco in terms of FCTC reporting and of grant. Work in progress. public-health policies, identify potential outcomes and implications for THR.

HST+ A,D i,ii,vii Knowledge Action Change To produce the first edition of the Global Produce the first edition of the Global Improved knowledge and access to knowledge for all on the No Fire, No Smoke: The Global State of Dec-17 Oct-18 Limited State of Tobacco Harm Reduction (GSTHR) State of Tobacco Harm Reduction global state of tobacco harm reduction. Tobacco Harm Reduction Report 2018 (GSTHR) report. (English and Chinese).

HST+ A,D i,ii,vii Knowledge Action Change Increase capacity for conducting and Increase organizational capacity for Increased organizational capacity for conducting and GSTHR website including information Dec-17 May-19 Limited understanding research related to tobacco conducting and understanding understanding research related to THR. database upon which the GSTHR harm reduction research related to THR. report is based.

HST+ A,D i,ii,vii Knowledge Action Change Translation of the executive summary of Translation of the executive summary Increased understanding, access to, and dissemination of GSTHR 2018, executive summary Oct-18 Nov-18 Limited GSTHR report from English to Arabic, of GSTHR report from English to the GSTHR report executive summary. (Arabic, Chinese, English, French, Chinese, French, Russian and Spanish Arabic, Chinese, French, Russian and Hindi, Indonesian, Japanese, Polish, Spanish. Portuguese, Russian, and Spanish).

HST+ A,D i,ii,vii Knowledge Action Change Production of a combination of online Increase the profile and extend Improved knowledge and access to knowledge for all on the Launch in Geneva on October 2, 2018, Sep-18 Dec-18 Limited broadcasts, special reports, interviews, and dissemination of the GSTHR report. global state of tobacco harm reduction report. with distribution to FCTC COP8 photojournalism pieces to increase the attendees. A communication targeting profile and extend the dissemination of the media, bloggers, key influential GTHR report worldwide and specially at people and 3,500 plus on KAC mail COP8 lists, and subsequent media coverage.

HST+ A,D i,ii,vii Knowledge Action Change Global State of Tobacco Harm Reduction Plan and deliver GSTHR report Road Promotion of and improved knowledge and access to Global State of Tobacco Harm Oct-18 Jan-20 Limited Road Shows Shows. knowledge for all on the global state of tobacco harm Reduction Road Shows website. reduction/GSTHR report.

HST+ A,D i,ii,vii Knowledge Action Change KAC Tobacco Harm Reduction Scholarship Extend KAC THR Scholarship Strengthened capacity of participants to understand, The KAC Global Tobacco Harm Feb-19 Aug-23 Limited Programme Programme for students and mentors develop, and implement evidence-based science relevant Reduction Scholarship Programme in LMICs. to THR and to contribute to the development of appropriate 2020 website. regulation standards.

HST+ A,D i,ii,vii Knowledge Action Change Global State of Tobacco Harm Reduction Consolidate GSTHRs position as a Updated and improved knowledge and access to 2020 Briefing Paper, Tobacco Harm Feb-19 Feb-24 Limited trusted source of robust, objective, knowledge for all on the global state of tobacco harm Reduction and the Right to Health and independent information on THR. reduction. (English, Spanish, Portuguese, Polish, German, Russian, and Chinese).

HST+ D ii Law Enforcement Action Build capacity to share stories that present Build capacity to share stories that Development of Filter’s media organizational framework, THR articles published and readily Dec-18 Jun-20 Partners (Filter Magazine) facts about THR and nicotine use to all present facts about THR and nicotine and capacity to tell stories that present the facts about available in the public domain (Filter stakeholders use to all stakeholders. harm reduction and nicotine use to all stakeholders, Magazine). Final reports due to be including the general public, and magazine readership. received.

HST A i,iii Lumos Diagnostics Pty Ltd Biomarker research program Scoping work for research concerning Detailed proposal for submission to FSFW. Final narrative report delivered to Oct-18 Jan-19 biomarkers of nicotine product FSFW. exposure (development of a rapid point of care assay).

HST A i,iii Lumos Diagnostics Pty Ltd The development of a rapid point-of-care Develop a rapid point of care assay to Building on phase-one scoping work, the development of a Deliverable will be available at the end Feb-19 Feb-21 (POC) assay panel that will be able to differentiate between multi-use of rapid point of care assay to differentiate between multi-use of grant. Work in progress. differentiate between multi-use of nicotine nicotine products. of nicotine products for use in future research. products.

HST B i,ii,iii Metaform Ventures LLC Proposal Development for Establishing Groundwork for development of a CoE Scoping work for development of full grant proposal and Final narrative report delivered to May-18 Aug-18 Center of Excellence in India in India. work leading to establishment of CoE in India. FSFW. HST B i,ii,iii Metaform Ventures LLC Chemical characterization of Indian Chemical characterization of SLTs in Compilation of background materials for development of Final report delivered to FSFW. Work Oct-18 Dec-18 products (slts) and In.dia long-term proposal to assess levels of harmful, and fed into development of long-term evaluation of the harm induced by these potentially harmful, constituents of smokeless tobacco proposal. products products sold in India.

HST B i,ii,iii Metaform Ventures LLC Indian Smokeless Tobacco Product Assess levels of harmful, and Strengthen capacity in India to carry out smokeless tobacco Deliverable will be available at the end Jul-19 Aug-20 Characterization potentially harmful, constituents of product characterization. of grant. Work in progress. smokeless tobacco products sold in India. Communicate findings to various stakeholders to standardize and regulate constituents of these products in India. HST and Other Approved Grants PAGE 7 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST A i,iii Nanocomposix Biomarkers to differentiate nicotine product Scoping work for research concerning Identification of a number of constituents that could Final narrative report delivered to Oct-18 Jan-19 types biomarkers of nicotine product potentially serve as biomarkers which could validate self- FSFW. exposure. reporting of product use. Examination of the feasibility of developing lateral-flow assays to these biomarkers as part of a two-year work plan.

HST A i Oncimmune Ltd Characterization of COVID-19 outcomes in a Investigate the nexus of COVID19 and To develop a better understanding of the linkages between Deliverable will be available at the end Jun-20 Sep-20 high-risk cohort: Assessment of background nicotine use. smoking and COVID-19 outcomes. of grant. Work in progress. levels of autoantibodies in an at risk population of smokers as a prognostic marker for severe COVID-19 infection.

HST A i Oncimmune Plc Establishment of a trust (the “Lung Trust”) To develop a vehicle dedicated to lung Establishment of registered Lung Trust. Lung Trust established. Mar-20 Jul-20 suitable for the application, receipt, and health and nicotine-use research. administration of future grant awards

HST B i Patras Science Park S.A. – Development of an Institute for Research Groundwork for development of an Scoping work for development of full grant proposal and Narrative report submitted to FSFW; May-18 Oct-18 Biohealth Hub and Innovation on THR- Perceived Risk Study Institute for Research and Innovation work leading to launch of Institute for Research and article published in peer-review and Intervention of Smoke-free Products in on THR. Innovation on THR. journal; public education events. Greece

HST B ii Patras Science Park S.A. – Development of an Institute for Research Bridging grant to retain staff and Retention of staff and experts with intention of full Staff retained. Nov-18 Jan-19 Biohealth Hub and Innovation on THR- Perceived Risk Study experts. availability for longer term project if approved. and Intervention of Smoke-free Products in Greece

HST A ii Qbal (Quality Belligerence) Identifying, assessing, and designing clinical Identify best-practice evaluation Identification of best practice and suitable evaluation Final Narrative report, "Identifying, Jul-19 Dec-19 trials and evaluation methods for readily methods for readily available tobacco methods for tobacco and nicotine product research. Assessing and Designing Clinical Trials available consumer products and nicotine consumer products. and Evaluation Methods," issued.

HST+ A i,ii Qbal (Quality Belligerence) Situation analysis and development of a Building an economic argument for Comprehensive report on tobacco economics in Pakistan. Deliverable will be available at the end Mar-20 Jul-20 comprehensive report on tobacco THR as one route to cessation in of grant. Work in progress. economics in Pakistan Pakistan .

HST A i,iii Rose Research Center, LLC Translational Research Center to Promote a Operationalization of a Translational Operationalization of a Translational Research Center for Multiple publicly available outputs Feb-19 Feb-24 Smoke-Free World Research Center for the evaluation of the evaluation of innovative smoking cessation and harm- generated (journal articles). Final innovative smoking cessation and reduction strategies to help individuals quit smoking. deliverable will be available at the end harm-reduction strategies to help of grant. Work in progress. individuals quit smoking.

HST A i,ii,iii San Francisco Study Centre Inc. Comparative Tobacco Interventions for Examine the acceptability and Feasibility study to support proposal for a larger Further deliverable will be available at Nov-19 Oct-22 Individuals with Severe and Persisting outcome of a harm-reduction intervention. the end of grant. Work in progress. Behavioral Health Disorders approach to tobacco use for individuals with serious behavioral health disorders and determine the association with decrease in smoking.

Industry A iv Sustainability Inc. Tobacco Transformation Index SustainAbility is responsible for First Tobacco Transformation Index scheduled to launch Project status available at https:// Feb-19 Oct-20 transforma stakeholder engagement, September 2020. tobaccotransformationindex.org/. tion development, and facilitation of an Index Advisory Panel, as well as post- publication project review.

HST A i,ii,iii University Of California San Interventions to reduce smoking among Comparative tobacco interventions for Scoping work for development of future grant proposal. Final narrative report delivered to May-18 Sep-18 Francisco, School Of Nursing people with mental health disorders individuals with severe and persisting FSFW. behavioral health disorders.

HST B i,ii University Of Cape Town Scoping work for establishment of an Scoping work for development of full grant proposal and Final narrative report delivered to May-18 Jan-19 African Centre Of Excellence For Smoking African CoE for Smoking and Mental work leading to establishment of an African CoE for FSFW. And Mental Health Health. Smoking and Mental Health. HST B i University Of Cape Town Bridging grant to retain staff and Retention of staff and experts with intention of full Full proposal for future work Feb-19 Apr-19 African Centre Of Excellence For Smoking experts. availability for longer term project, and completion of work submitted to FSFW. And Mental Health on long-term proposal. HST B i University Of Stellenbosch, Planning for a possible future Centre Better understanding of the complex ethical dimensions Final narrative report delivered to Jun-18 Nov-18 Business School Developing an ethical framework for a of Excellence at Stellenbosch surrounding smoking, tobacco control, and tobacco harm FSFW. smoke-free world University. reduction. HST and Other Approved Grants PAGE 8 OF 8

HST Strategic Foundation Project End Pillar Aim Purposes Organization Project Title Purpose Expected Outcomes / Outputs Actual / Current Outputs Approval Date HST+ A I,vii University Of Virginia - Institute "Breaking the Cigarette Habit in an Evolving Convening dialogue on tobacco, Delivery of dialogue on tobacco, nicotine, and THR. Event successfully planned and Apr-18 Oct-19 For Environmental Negotiation Tobacco, Nicotine and Alternative Products nicotine, and ANDs Harm Reduction. executed. Landscape"

HST+ D i,ii Vida News LLC VIDA News & World Storytellers Increase public awareness of the Increased public awareness of the drivers of smoking, Two videos (each with ~1,000 views). Nov-19 Jan-21 drivers of smoking, health harms, and health harms, and of the availability of safer alternatives Work in progress. of the availability of safer alternatives with a view to quitting or switching. with high production-value evidence- based interviews, short documentaries, infographics, and social media involving FSFW grantees, other researchers, physicians, advocates and consumers with a strong global focus and a specific focus on India.

HST+ D i Yale University Tobacco cessation and harm reduction in the Global review of tobacco cessation Global review of tobacco cessation and harm-reduction Final report submitted to FSFW; two Jun-19 Oct-20 Global South and harm-reduction science. science and research, including characterization of funder peer-reviewed journal articles and PI location. published.

HST+ D i Yale University Support Yale University to work with Signals Provision of evidence-based data for Provision of evidence-based data for evaluation and trends Deliverable will be available at the end Mar-20 Nov-20 Analytics as Signal Adapts a platform already evaluation and trends monitoring. monitoring. of grant. Work in progress. in use for FSFW to help in humanitarian efforts around COVID-19

HST+ A i Yayasan Pena Bulu Scoping Study on Tobacco Economic To conduct a scoping "Study on Scoping research to better understand the economic costs Deliverable will be available at the end May-20 Nov-20 Ecosystem in Indonesia Tobacco Economic Ecosystem" in and health burden associated with tobacco morbidity and of grant. Work in progress. Indonesia. mortality in Indonesia. Full proposal for phase-two work is expected.

HST A i,ii Youth Bridge, Inc. In-depth assessment on the culture of In-depth assessment on the culture of In-depth assessment on the culture of smoking in Liberia, Full study report delivered to FSFW. May-18 Sep-18 smoking in Liberia smoking in Liberia including barriers to quitting.

HST A i,ii Youth Bridge, Inc. In-depth assessment on the culture of To retain staff and experts Retention of staff and experts with intention of full Key personnel retained. Oct-18 Dec-18 smoking in Liberia availability for longer term project if approved.

HST A i,ii Youth Bridge, Inc. Framing Practical Solutions to Ending Determine preintervention conditions An overview of smoking-cessation services and facilities in Full narrative report submitted to Dec-18 Dec-19 Smoking In Liberia and best-practice strategies to end Liberia and their standards of operation as well as an FSFW. smoking in Liberia assessment of further needs. The knowledge and practices of individuals who smoke in regards to THR products were reported. Several collaborations with other institutions have been set up.