And Ozone Therapy

Ozone Velio Bocci Ozone A New Medical Drug Second Edition 1 3 Velio Bocci Department of Physiology University of Siena via A. Moro 2 53100 Siena Italy [email protected] ISBN 978-90-481-9233-5 e-ISBN 978-90-481-9234-2 DOI 10.1007/978-90-481-9234-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010936097 © Springer Science+Business Media B.V. 2005, 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) This book is dedicated to all patients with the wish to regain their health with or without oxygen-ozonetherapy Foreword In 2002, Prof. Bocci published a book entitled “Oxygen-Ozone Therapy. A Critical Evaluation” with ample scientific data based largely on his experiments indicat- ing the usefulness and atoxicity of ozone therapy in some diseases. However the book contained too many details and it was difficult to read for the busy physi- cian and even more for the layman. He has now written a new version that is shorter and concise. Nonetheless the mechanisms of action of ozone, which are essential for understanding how ozone acts through a number of messengers, are clearly explained in a scientific but plain language. The clinical part has been greatly extended and includes new pathologies as well as diseases previously considered but now amplified with new data. The book is primarily intended for ozone-therapists, who want to refine tech- niques, expand treatment modalities and solve problems, but will be equally useful for physicians interested in this approach. However it can also be read by the layman, to provide further insight into this aspect of complementary medicine. The book gives a complete view of this approach including practical aspects of routes of administration and the possibility of simple self-medication. Against the prejudice that ozone is toxic, the accurate description of side effects reveals that they are of minimal relevance and it is even more surprising that ozone therapy yields a feeling of wellness in the majority of patients. This is a crucial point that has been clearly explained by defining the therapeutic range within which ozone is a very useful drug. It is interesting to learn that ozone can slowly induce an increase of antioxidant defences that is a unique property most important for correcting the chronic oxidative stress plaguing atherosclerosis, diabetes, viral infections and cancer. I have been impressed by the enthusiasm for this therapy that comes to light on reading the book. Velio told me that he has submitted himself all possible methods of ozone administration and has also performed many experiments. From his results and the often incredible improvements observed in very ill patients, he has the firm conviction that ozone therapy is not a placebo! Jokingly, he also assured me that he is the living proof of ozone therapy atoxicity. Ozone never finishes surprising us by its versatility recently shown by delivering therapeutic activity in Orthopaedics and Dentistry. I am convinced that Velio’s work vii viii Foreword will dispel misconceptions and scepticism and it will be useful for years to come both to physicians and patients, who like to understand the meaning of the treatment. Indeed this book represents the first comprehensive framework for understanding and recommending ozone therapy in some diseases. London The Lord Colwyn August 2004 Preface (Second Edition, 2010) Five years have elapsed from the first Edition published in 2005 and, in the mean- time, work from mine and other Laboratories and clinics has further clarified and improved the use of ozonetherapy. However, in spite of some new work performed in Italy and other Countries, it is unfortunate that important clinical studies performed according to the Helsinki’s paradigm have not yet been performed or published. A small exception is represented by a Cuban trial but their clinical investigation of the diabetic foot by using only 20 days of rectal insufflation of ozone is too good to be realistic and it needs to be confirmed by a far more reliable procedure as the ozonated autohemotherapy. As far as I know, good journals do not accept papers based on such imprecise procedure as the rectal insufflation of ozone. An experimental work carried out in Germany on a experimental cancer model in rabbits was interesting for examining the intraperitoneal route but as I pointed out in a letter to the Editor of the Int J Cancer, as it also has happened for other approaches, experimental acute cancer in animals cannot be equated to the slow progressing human cancers. But the worst publication was a clinical trial published in the Lancet, January 2008 reporting the failure of a repeated administration of a small (10 ml) volume of blood ozonated with as many as 75 mg ozone + UV treatment and + heat-stress in patients. This publication show how an absolutely irrational and irresponsible procedure called Celacade can seriously damage the ozonetherapy concept. Although I wrote a severe counter-point to the Lancet, the damage has not yet been corrected because in spite of my efforts, it has not yet been possible to carry out an appropriate trial in chronic heart failure. Thus, where we are now? We know how ozone works, the precise therapeutic window, its absolute safety newly established in recent papers and the very likely advantages of ozonetherapy over current orthodox medicine in vascular diseases and in the dry form of age-related macular degeneration. We are now sure that ozonetherapy can represent a useful support in chronic infections and it has been accepted in orthopaedics and dentistry. However prejudice and lack of knowledge persist in official medicine and it will be impossible to eradicate them unless we can provide extensive, controlled and randomized studies published in peer-reviewed international journals. Nonetheless this new edition reports several ix x Preface (Second Edition, 2010) technical improvements and a more detailed description of ozone posology in several diseases. Therefore it was thought necessary to improve and adjourn the book that hopefully may help physicians for the next decade. Siena, Italy Velio Bocci January 30, 2010 Preface (First Edition, 2005) Is there any reason to write a third book on the topic of oxygen-ozone therapy? The first was written 4 years ago for Italian physicians, who, for some time, had complained about the lack of precise ozone informations. Then it became unavoid- able to write a book for English-speaking people and it took a couple of years because I considered worth it while to examine the problem in details with atten- tion to basic findings, so that it could also be useful to scientists and clinicians. The book was briefly reviewed in the New York Academy of Sciences Magazine (1–2, 2003, 14) and was awarded the “Tramezzi” prize in Rome, October 2003. However the book had not been as successful as I had hoped because, particularly American scientists remained sceptical and disinterested. However a letter from Prof. L. Packer was encouraging saying: “there is growing evidence that oxidants like many ROS including ozone provide a mild oxidant stress which under certain circumstances actually induce the formation of phase 1 and phase 2 enzymes, strengthening the antioxidant defence system through an adaptation process. Thus it would be rational that a mild treatment with ozone stimulates the antioxidant defence system. So I think some of your ideas have a foundation in current scientific work.” Indeed I have several reasons to believe that one of the most important pedestals of ozonetherapy is based on the induction of oxidative stress proteins. In Chapter 34 of my previous book (2002), I emphasized the usefulness of biooxidative therapies in poor-countries, where a billion people have no other medical resources but world health authorities, particularly WHO had remained disinterested in this approach. It is depressing to realize how useful proposals remain unheard of and how much time and work are requested before their implementation. However, the worst disappointment has been on reading a few letters of distin- guished American scientists in the field of free-radicals, who were and remained biased towards ozonetherapy. Actually several scientists, who surely received the book did not even bother to answer. Someone, who, by reading his papers, I judged to be very clever, politely wrote me that, although the book presented some interesting aspects, it could not convince him because the ruling dogma in the USA is that “ozone is toxic and should not be used in medicine”. Although several others were xi xii Preface (First Edition, 2005) not so naïve to say such a thing, it was clear that the book had failed to remove the prejudice from their heads. On the other hand, I received a few positive responses from clinicians, who appre- ciated my effort in creating a rational scheme able to clarify how ozone acts and why toxicity could be avoided. Several practitioners confessed to be disinterested in the biochemical aspects because they hardly had the time to read the practical part. On the whole these remarks taught me that much more work was needed before reversing the antagonism, for correcting the problem of charlatans and objectively establish the pros and cons of ozonetherapy.

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