DOCSLIB.ORG

Increasing the Effectiveness of Intravenous Vitamin C As an Anticancer Agent

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Increasing the Effectiveness of Intravenous Vitamin C As an Anticancer Agent JOM Volume 30, Number 1, 2015 Educational Article 45 Increasing the Effectiveness of Intravenous Vitamin C as an Anticancer Agent Michael J. Gonzalez NMD, DSc, PhD, FANMA, FACN;1 Jorge R. Miranda-Massari PharmD;2 Jorge Duconge PhD;2 Miguel J. Berdiel MD;3 1,2University of Puerto Rico, Medical Sciences Campus, RECNAC 2 Project, Schools of Public Health and Phar- macy3 Pontifical Catholic University, Dept. of Biology. *Correspondence should be addressed to: Dr. Michael J Gonzalez, University of Puerto Rico, Medical Sciences Campus School of Public Health, Department of Human Development, Nutrition Program, GPO Box 365067 San Juan PR 00936-5067; email: [email protected] Abstract Vitamin C has been mentioned as an agent with chemotherapeutic potential since 1952. Physiological concentrations of vitamin C (L-ascorbate or L-ascorbic acid) in the body are controlled through intestinal absorption, tissue accumulation, and renal reabsorption and excretion. Therefore, intravenous administration is used to achieve pharmacologic doses not attainable by other means. In relation to intravenous administration of ascorbate, high-dose intravenous vitamin C (>0.5 g/kg body weight) has several effects: cytotoxicity for cancer cells but not for normal cells; improved quality of life for cancer patients; protection of normal tissues from toxicity caused by chemotherapy; rein- forcement of the action of radiation and some types of chemotherapy; immune system enhancement; and strengthening of collagen and hyaluronic acid. In this article we discuss important therapeutic variables that the clinician faces that are key for increasing the effectiveness of intravenous vitamin C as an anticancer agent. Introduction d. Increases appetite. After over 60 years of experience with 2. Reduces many complications of the disease:11- vitamin C and Cancer, what can we say 16 about vitamin C as an anticancer agent? The a. Resolves ascorbate’s insufficiency in the extensive experience and published papers cancer patient. on vitamin C and cancer demonstrate that b. Combats infections (viral, bacterial, fun- the use of high dose, both oral and intrave- gi). nous (IV) vitamin C is remarkably safe.1-7 c. Decreases cancer-associated inflamma- Additionally, the vast number of publica- tion. tions confirm that it possesses many thera- d. Prevents cancer associated sepsis. peutic benefits. 3. Pharmacological doses of vitamin C have 1. Improves quality of life of cancer patients:8- shown to have cytostatic or cytotoxic action in 10 cancer cells through a variety of mechanisms:17 a. Decreases adverse effects of standard can- a. Fuel control of malignant cells by glucose cer treatments. antagonism. b. Reduces pain. b. Electron donor for the energy redox c. Increases energy. problem present in cancer. 46 Journal of Orthomolecular Medicine Vol 30, No 1, 2015 c. Increases hydrogen peroxide formation. Relevant physiological/cellular d. Increases collagen formation. variables to consider when improv- e. Enhances immune parameters (cellular ing the effectiveness of IV Vitamin C and humoral). therapy f. Sustains and improves the effect of 1. Level of tissue oxygenation: The level standard antineoplastic agents. of tissue oxygenation may be the most im- portant limiting factor in the anticancer Discussion activity of high dose IV vitamin C. As we Many patients have shown impressive are well aware of one of the most impor- responses in tumor size reduction, improve- tant mechanisms by which vitamin C exerts ment in pain control, increased energy lev- its anticancer action is by the production els and appetite, in general we can state that of hydrogen peroxide. For this to occur, the most patients improve their quality of life presence of sufficient oxygen is a requisite. but nevertheless total effectiveness of the Limited oxygen availability reduces the use of IV vitamin C as an anticancer agent chances of the production of hydrogen per- has not been achieved. Results in some in- oxide from the conversion of ascorbic acid stances have been variable. This may be due to dehydroascorbic acid. We propose the to a number of direct interacting variables. utilization of hyperbaric oxygen immediate- In order to consistently improve cancer ly after IV vitamin C therapy to increase its patient outcomes, it is important to have a effectiveness as an anticancer agent, in order comprehensive evaluation of the therapeutic to increase the formation of hydrogen per- protocol that allows us to identify contrib- oxide, and therefore enhance the anticancer uting factors that promote health deteriora- effect of IV vitamin C. tion and the barriers to achieve total healing. In relation to ozone, it is known that vi- These must be identified and corrected. tamin C is antagonistic to ozone, although it has been shown that ozone does not to These variables include but are not limited to: break down vitamin C in the body. Patients 1. Cell energy related metabolic taking therapeutic doses of vitamin C either derangements.18-20 orally or via IV infusion, should take the 2. Toxicities (e.g., tobacco, alcohol, pesti- ozone treatment first, then wait 30 minutes, cides, heavy metals, hydrocarbons, and food and then take the vitamin C dose. nitrosamines).21-28 3. Medications (i.e., opioids impair im- General Aspects of Oxygenation mune response, increase angiogenesis, and a) Hyperbaric Oxygen: Increases oxygen to may even act directly on tumor cells to en- tissues. courage their growth and spread. There are b) Ozone: Increases oxygen. An Italian epidemiologic, animal, and cellular studies group postulates that a prolonged cycle of that suggest a role of mu opioid receptors on ozonated autohemotherapy may correct tu- cancer growth and metastasis).29-31 mor hypoxia, lead to less aggressive tumor 4. Hormonal imbalances/endocrine disrup- behavior. Improving oxygen levels would be tors.32,33 expected to favor the anticancer effect of vi- 5. Excessive inflammation.34,35 tamin C.42 Ozone therapy has been reported 6. Infectious agents and the balance of the to produce an increase in red blood cell gly- body flora.36,37 colysis rate. This leads to stimulation of 2, 3 7. Excessive psychological stress.38,39 diphosphoglycerate which then allows a rise 8. Excessive exposure to radiation.40,41 of the oxygen released to the tissues. Ozone Ten percent of invasive cancers are re- facilitates the Krebs’s cycle by improving lated to radiation exposure, including both the oxidative carboxylation of pyruvate and ionizing radiation and non-ionizing radia- promoting the synthesis of ATP. There is tion. Increasing the Effectiveness of Intravenous Vitamin C as an Anticancer Agent 47 also an increase in antioxidant enzymes that tion, alteration of tumor microenvironment, act as free radical scavengers (such as glu- induction of genotoxic responses, reduction tathione peroxidase, catalase and superoxide of immune action and metabolic derange- dismutase).43 Vasodilation is also induced ments.47 by ozone which leads to increased oxygen c) Sodium bicarbonate: May correct tissue and nutrients and immune factors available acidosis produced by increased fermenta- to the cell.44 Ozonized autohemotransfu- tion. Sodium bicarbonate also has a specific sion may be useful to improve both the poor ability that is, not possessed by other basic rheological properties of the blood and the compounds to destroy fungi colonies.48,49 oxygen delivery to tissues45 and therefore in- d) Dichloroacetic Acid: May improve mi- crease oxygen, immune factors and nutrients tochondrial function by facilitating oxida- that improve healing and tumor response. tive phosphorylation which is lacking in the Animal studies have shown very significant cancer cell.49,50 increased survival in advanced head and neck squamous cell carcinomas with the applica- 2. Level of Blood Glucose:51,52 Excessive tion of ozone. Although the mechanisms for blood glucose can compete with vitamin C this effect has not been totally elucidated, it for the glut receptor sites. It is a good thera- is believed that various important immune- peutic approach to provide the high dose IV modulatory effects in macrophages, poly- vitamin C in an empty stomach. Neverthe- morphonuclear cells (PMN), NK cells, and less we should be aware that sleepiness and cytotoxic T lymphocytes are involved as hypoglycemia symptoms may arise. Receiv- well as other metabolic modulatory effects.46 ing these IVs causes the body to produce Therefore, although at the present time there insulin because it believes that the blood is no solid evidence that ozone can improve sugar is spiking. Patients might experience the anticancer activity of vitamin C, given hypoglycemia-like symptoms. If their blood the scope of its biological effects, it might be sugar is measured during the infusion of IV important to test this combination. vitamin C, the meter reads an enormously –Increases oxygen metabolism: More high number because the body thinks that oxygen availability activates of the Krebs the vitamin C is sugar. So having a reduced cycle, increases oxidative decarboxylation level of blood sugar seems to be a necessary of pyruvate and ATP production. The ad- parameter to increase IV vitamin C’s anti- ditional supply of oxygen oxidizes the lipid cancer effectiveness. layer of malignant cells and destroys them through cell lysis (apoptosis). Oxygen re- 3. Physiological Red-Ox balance:53,54 The acts with the unsaturated fatty acids of the balance between oxidation and anti-oxida- lipid layer in cellular membranes, forming tion is believed to be critical in maintaining hydroperoxides. Lipid peroxidation products healthy biological systems. Reactive oxygen include peroxyl radicals and aldehydes that species (ROS) and reactive nitrogen species possess killer cell action. (RNS) play important roles in regulation of –Increases circulation: Permits more cell survival. In general, moderate levels of oxygen, vitamin C and immune factors to be ROS/RNS may function as signals to pro- delivered to the tissues. mote cell proliferation and survival, whereas –Decreases bacteria/viral/fungi load: severe increases of ROS/RNS can induce cell Microbes are important modulators of the death.
Load more

Recommended publications
  • Ozone Therapy: Beyond Oxygen the Most Needed Adjunct to Veterinary Medicine Introduction of Ozone
    Ozone Therapy: Beyond Oxygen The Most Needed Adjunct to Veterinary Medicine Introduction of Ozone Margo Roman, D.V.M., CVA, COT, CPT MASH Main St Animal Services of Hopkinton Hopkinton MA 01748 www.mashvet.com • OZONE is a trivalent oxygen molecule. Three O2 + electrical spark/ lightning= 2 O3. It is very reactive and will return to 3 O2 molecules giving high levels of O2. Healthy cells need Oxygen • Ozone is one of the most beneficial substances on this planet, and the BAD science you hear quoted on the news every night is causing you to subconsciously be afraid of nature, and therefore, a part of life itself. They tell you that somehow hydrogen plus nitrogen or sulfur equals ozone. H + N + S = 03? Not on this planet it doesn't! What is ozone? Simply, oxygen. Three atoms of nature's oxygen. It exists in a very active form for about 30 minutes before breaking down into two atoms of regular oxygen - by giving up one atom of singlet oxygen. Where does ozone come from? Nature. And nature is efficient. The new growth in the forests, the trees, the grass on your front lawn, and the plankton in the ocean are continually creating oxygen. • • If you have seen Inconvenient Truth, the Al Gore documentary on Global warming, there is one scene that brings it all together. In one section he discusses the CO2 levels over the Pacific Ocean. In addition to the original measurements that began in 1965, they were able to measure the levels from hundreds of years ago by taking samples from deep within glaciers.
    [Show full text]
  • Ozone Therapy Has Been Utilized and Heavily Studied for More Than a Century
    Ozone Ozone is a therapy that delivers oxygen at the cellular level aiding your body to be more Therapy powerful and to function better under stress. “Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical ozone is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast, and protozoa, stimulation of oxygen metabolism, activation of the immune system.” Elvis, A.M. Ozone Therapy: A Clinical Review. Journal of Natural Science, Biology, and Medicine. 2011 Jan-Jun; 2(1):66-70. What is Ozone is a naturally occurring gas that has very useful medical applications. Ozone OZONE (O3)? can also be produced from medical grade oxygen and use of an ozone generator. Ozone in small concentrations is safe and effective in preventing and treating a host of different illnesses and diseases. The oxygen that we breathe and circulate in our bodies contain two oxygen atoms (O2). Ozone is made up of three oxygen atoms (O3). You may be wondering how does ozone change into oxygen? An ozone molecule is eager to give away one of its oxygen atoms. When two of the "freed up" oxygen atoms connect and bond together a new oxygen molecules is created; O + O => O2 (oxygen!). This process is called oxidation. Vitality Medical Infusions Ozone Therapy 1/3 If Ozone is so Ozone is not a "drug" that can be patented by drug companies & BIG PHARMA. It’s a Beneficial why natural substance that can also be produced inexpensively.
    [Show full text]
  • Ozone in Medicine. the Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases
    International Journal of Molecular Sciences Article Ozone in Medicine. The Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases Renate Viebahn-Haensler 1,*,† and Olga Sonia León Fernández 2,*,† 1 Medical Society for the Use of Ozone in Prevention and Therapy, Iffezheim, D-76473 Baden-Baden, Germany 2 Pharmacy and Food Institute, University of Havana, Coronela, Lisa, Havana 10 400, Cuba * Correspondence: [email protected] (R.V.-H.); [email protected] (O.S.L.F.) † Both authors contributed equally. Abstract: Low-dose ozone acts as a bioregulator in chronic inflammatory diseases, biochemically char- acterized by high oxidative stress and a blocked regulation. During systemic applications, “Ozone peroxides” are able to replace H2O2 in its specific function of regulation, restore redox signaling, and improve the antioxidant capacity. Two different mechanisms have to be understood. Firstly, there is the direct mechanism, used in topical treatments, mostly via radical reactions. In systemic treatments, the indirect, ionic mechanism is to be discussed: “ozone peroxide” will be directly reduced by the glutathione system, informing the nuclear factors to start the regulation. The GSH/GSSG balance outlines the ozone dose and concentration limiting factor. Antioxidants are regulated, and in the case of inflammatory diseases up-regulated; cytokines are modulated, here downregulated. Rheumatoid Citation: Viebahn-Haensler, R.; arthritis RA as a model for chronic inflammation: RA, in preclinical and clinical trials, reflects the León Fernández, O.S. Ozone in pharmacology of ozone in a typical manner: SOD (superoxide dismutase), CAT (catalase) and finally Medicine. The Low-Dose Ozone GSH (reduced glutathione) increase, followed by a significant reduction of oxidative stress.
    [Show full text]
  • Complementary and Alternative Medicine Table of Contents Related Coverage Resources
    Medical Coverage Policy Effective Date ............................................. 2/15/2021 Next Review Date ....................................... 2/15/2022 Coverage Policy Number .................................. 0086 Complementary and Alternative Medicine Table of Contents Related Coverage Resources Overview.............................................................. 1 Acupuncture Coverage Policy .................................................. 1 Atherosclerotic Cardiovascular Disease Risk General Background ........................................... 3 Assessment: Emerging Laboratory Evaluations Medicare Coverage Determinations .................. 36 Attention-Deficit/Hyperactivity Disorder (ADHD): Coding/Billing Information ................................. 37 Assessment and Treatment References ........................................................ 39 Autism Spectrum Disorders/Pervasive Developmental Disorders: Assessment and Treatment Biofeedback Chiropractic Care Drug Testing Hyperbaric and Topical Oxygen Therapies Physical Therapy INSTRUCTIONS FOR USE The following Coverage Policy applies to health benefit plans administered by Cigna Companies. Certain Cigna Companies and/or lines of business only provide utilization review services to clients and do not make coverage determinations. References to standard benefit plan language and coverage determinations do not apply to those clients. Coverage Policies are intended to provide guidance in interpreting certain standard benefit plans administered by Cigna Companies. Please
    [Show full text]
  • Cigna Medical Coverage Policy
    Cigna Medical Coverage Policy Subject Complementary and Effective Date ............................ 7/15/2014 Alternative Medicine Next Review Date……………….7/15/2015 Coverage Policy Number ................. 0086 Table of Contents Hyperlink to Related Coverage Policies Coverage Policy .................................................. 1 Acupuncture General Background ........................................... 3 Attention Deficit/Hyperactivity Disorder Coding/Billing Information ................................. 21 (ADHD): Assessment and Treatment References ........................................................ 23 Autism Spectrum Disorders/Pervasive Developmental Disorders: Assessment and Treatment Biofeedback Atherosclerotic Cardiovascular Disease Risk Assessment: Emerging Laboratory Evaluations Chiropractic Care Hyperbaric Oxygen Therapy, Systemic & Topical INSTRUCTIONS FOR USE The following Coverage Policy applies to health benefit plans administered by Cigna companies. Coverage Policies are intended to provide guidance in interpreting certain standard Cigna benefit plans. Please note, the terms of a customer’s particular benefit plan document [Group Service Agreement, Evidence of Coverage, Certificate of Coverage, Summary Plan Description (SPD) or similar plan document] may differ significantly from the standard benefit plans upon which these Coverage Policies are based. For example, a customer’s benefit plan document may contain a specific exclusion related to a topic addressed in a Coverage Policy. In the event of a conflict, a customer’s
    [Show full text]
  • Trigeminal Neuralgia
    www.biogenericpublishers.com Article Type: Research Article Received: 25/06/2020 Published: 07/07/2020 DOI: 10.46718/JBGSR.2020.02.000056 Ozone Therapy in the Treatment of Symptoms Associated to Trigeminal Neuralgia Ioana Soare1 and Roxana Mirica2* 1Associate Professor, primary care physician for medical expertise and work capacity recovery, Faculty of Medicine, Titu Maiorescu University of Bucharest, Romania 2Assistant Professor, primary care physician for medical expertise and work capacity recovery, Carol Davila Medicine and Pharmacy University of Bucharest, Romania *Corresponding author: Mirica, Assistant Professor, primary care physician for medical expertise and work capacity recovery, certified for Bach flower remedies, Carol Davila Medicine and Pharmacy University of Bucharest, 60,Grigore Alexandrescu street, District 1, zip code 010626, Bucharest, Romania ORCID ID: 0000-0003-0068-3895 Abstract Background Trigeminal neuralgia: Manifests as an extremely intense neuropathic pain that affects the patient’s life in all its aspects. The classical -according to the guides -treatment with Carbamazepine has various adverse reactions. Patients have a low compliance too, and stop the treatment. Analgesia through acupuncture was thoroughly studied in the meta-analysis conducted by Vickers et al. on 20,827 patients in 2017. We propose ozone therapy on trigger points as treatment, the antialgic effect of acupuncture being doubled with the trophic effect of the oxygen. Treatment, the antialgic effect of acupuncture being doubled with the trophic effect of the oxygen. Measures: A 54 years old patient with hemicrania and hypersensitivity on the right side of the face, who spoke with his mouth almost closed, after 12 sessions of ozone therapy, felt no pain, the symptoms were significantly improved.
    [Show full text]
  • Oxidation Attendees List for Website Revised 07-25-17
    I am pleased to post a listing of health professionals my wife and I have personally trained in oxidation methods. Please note that this is a partial list only. Others might not want their names listed for business, legal, or other reasons. You might go to www.acam.org or www.icimed.org to look for a listing of integrative doctors in your area. Many list some form of oxidation therapy in their practice summary on these sites. Generally these doctors will know who in their area offers oxidation. I have included contact information, the date of training with us (if available), and specific oxidation techniques these professionals currently offer, as these professionals so informed me. I will update this list as more are trained, or more previously trained indicate that they wish to be listed. Please note that I have limited the listing of services provided here to those services related to oxidation only. Most, if not all of these fine healers will offer chelation, other IV and detoxification services, and perhaps many other healing modalities. I have not listed those services here. Any physician wise enough to use oxidation, in my humble opinion, will offer a great home for overall healing. Please note that high dose intravenous (IV) vitamin C is an oxidation therapy! (UV and UBI connote ultraviolet blood irradiation therapy). (OHT is intravenous ozone high dose therapy, the same as “10 pass”.) DIV is direct intravenous ozone gas administration. Listing by state or country is in alphabetical order. Please look at each for closest. USA Arizona Brian Archambault NMD West Valley Naturopathic Center 1646 N.
    [Show full text]
  • Complementary and Alternative Medicine
    Corporate Medical Policy Complementary and Alternative Medicine File Name: complementary_and_alternative_medicine Origination: 12/2007 Last CAP Review: 2/2021 Next CAP Review: 2/2022 Last Review: 2/2021 Description of Procedure or Service The National Center for Complementary and Integrative Medicine (NCCIH), a component of the National Institutes of Health, defines complementary, alternative medicine (CAM) as a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional or allopathic medicine. While some scientific evidence exists regarding some CAM therapies, for most there are key questions that are yet to be answered through well-designed scientific studies-questions such as whether these therapies are safe and whether they work for the diseases or medical conditions for which they are used. Complementary medicine is used together with conventional medicine. Complementary medicine proposes to add to a proven medical treatment. Alternative medicine is used in place of conventional medicine. Alternative means the proposed method would possibly replace an already proven and accepted medical intervention. NCCIM classifies CAM therapies into 5 categories or domains: • Whole Medical Systems. These alternative medical systems are built upon complete systems of theory and practice. These systems have evolved apart from, and earlier than, the conventional medical approach used in the U.S. Examples include: homeopathic and naturopathic medicine, Traditional Chinese Medicine, Ayurveda, Macrobiotics, Naprapathy and Polarity Therapy. • Mind-Body Medicine. Mind-body interventions use a variety of techniques designed to enhance the mind’s capacity to affect bodily functions and symptoms. Some techniques have become part of mainstream practice, such as patient support groups and cognitive-behavioral therapy.
    [Show full text]
  • Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects
    antioxidants Review Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects Bernardino Clavo 1,2,3,4,5,* , Francisco Rodríguez-Esparragón 1 , Delvys Rodríguez-Abreu 6, Gregorio Martínez-Sánchez 7, Pedro Llontop 8 , David Aguiar-Bujanda 9 , Leandro Fernández-Pérez 4 and Norberto Santana-Rodríguez 4,10,11 1 Research Unit, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain; [email protected] 2 Chronic Pain Unit, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain 3 Radiation Oncology Department, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain 4 Universitary Institute for Research in Biomedicine and Health (IUIBS), Molecular and Translational Pharmacology Group, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain; [email protected] (L.F.-P.); [email protected] (N.S.-R.) 5 Spanish Group of Clinical Research in Radiation Oncology (GICOR), 28290 Madrid, Spain 6 Medical Oncology Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain; [email protected] 7 Scientific Advisor, Freelance, 60126 Ancona, Italy; [email protected] 8 Experimental Medicine and Surgery Unit of Hospital Gregorio Marañon and the Health Research Institute of Hospital Gregorio Marañon (IiSGM), 28007 Madrid, Spain; [email protected] 9 Medical Oncology Department,
    [Show full text]
  • Apresentação Do Powerpoint
    Are the integrative practices recently incorporated into the Brazilian public healthcare system supported by evidence from Cochrane Reviews? Riera R1,2, Dittrich NH1, Pacheco RL1,3, Latorraca COC1, Martimbianco ALC3,4, Atallah AN1,5 1 Universidade Federal de São Paulo (Unifesp), Brazil 2 Hospital Sírio-Libanês, Brazil 3 Centro Universitário São Camilo, Brazil 4 Universidade Metropolitana de Santos (UNIMES), Brazil 5 Cochrane Brazil, Brazil The Problem Methods In March 2018, the Brazilian Ministry of Health announced 10 new integrative practices as part of the list of procedures available in the Brazilian public healthcare system, Sistema Único de Saúde (SUS). SUS, a free and universal system, has a limited budget, and all interventions should be fairly supported by good Apitherapy quality studies before its implementation. We summarized the evidence from Cochrane Reviews (CRs) Aromatherapy about these 10 interventions [1]. Bioenergetics Family constellation Key Results Chromotherapy Clay therapy Search was carried out in March 2018: 189 reviews. 16 CRs were included. Only 4 of the 10 integrative Hypnotherapy practices (apitherapy, aromatherapy, hypnotherapy and ozone therapy). For six integrative Hand imposition interventions (bioenergetics, family constellation, chromotherapy, geotherapy, flower therapy, and Ozone therapy hand imposition), no CR was found. The certainty of evidence ranged from unknown to high. The high- Flower therapy certainty evidence: honey dressings for partial thickness burns, honey for acute cough in children, and venom immunotherapy for systematic reaction to an insect sting. Almost the totality of the new interventions incorporated by Brazilian Ministry of Health in 2018 are not support by evidence from Cochrane Reviews. Sensitive search strategy Table 1.
    [Show full text]
  • Effectiveness of Acupuncture, Ozonio Therapy and Low-Intensity Laser in the Treatment of Temporomandibular Dysfunction of Muscle
    Original Article © 2018 - ISSN 1807-2577 Effectiveness of acupuncture, ozonio therapy and low-intensity laser in the treatment of temporomandibular dysfunction of muscle origin: a randomized controlled trial Efetividade da acupuntura, ozonioterapia e do laser de baixa intensidade no tratamento da disfunção temporomandibular de origem muscular: um ensaio clínico randomizado Síglia Adriana Campos TORTELLIa , Leonardo SARAIVAa* , Daniela Cristina MIYAGAKIa aUPF – Universidade de Passo Fundo, Passo Fundo, RS, Brasil How to cite: Tortelli SAC, Saraiva L, Miyagaki DC. Effectiveness of acupuncture, ozonio therapy and low-intensity laser in the treatment of temporomandibular dysfunction of muscle origin: a randomized controlled trial. Rev Odontol UNESP. 2019;48:e20190107. https://doi.org/10.1590/1807-2577.10719 Resumo Introdução: Uma das causas mais comuns de dores orofaciais é a disfunção temporomandibular (DTM). Objetivo: O objetivo deste estudo foi comparar a efetividade da acupuntura, ozonioterapia e laserterapia no tratamento de pacientes com DTM muscular, através de um ensaio clínico randomizado. Material e método: Foram avaliados 12 professores e estudantes de pós-graduação da Universidade de Passo Fundo, diagnosticados com DTM, com faixa etária entre 23 e 50 anos, de ambos os sexos. Os indivíduos foram divididos aleatoriamente em 3 grupos: G1: laserterapia, G2: acupuntura, e G3: ozonioterapia. Foram aplicados questionários de diagnóstico de DTM (RDC/TMD), questionário de Qualidade de Vida (OHIP-14), Escala de dor (EVA) e mensuração de abertura bucal máxima. Para caracterização da amostra, utilizaram-se estatísticas descritivas e percentagem, que foram apresentadas empregando-se distribuições de frequências absolutas e relativas. As variáveis qualitativas foram analisadas com os testes de Wilcoxon Resultado: Não houve diferença estatisticamente significativa entre os tratamentos.
    [Show full text]
  • WT/ACC/SPEC/RUS/21 Página 143 DOCUMENTO DE REFERENCIA 13 Lista De Mercancías Sujetas a Certificación Obligatoria Antes De Su
    WT/ACC/SPEC/RUS/21 Página 143 DOCUMENTO DE REFERENCIA 13 Lista de mercancías sujetas a certificación obligatoria antes de su despacho en el territorio aduanero de la Federación de Rusia (Anexo a la Orden Nº 496, de 14 de agosto, del Comité Estatal de Aduanas de la Federación de Rusia) Parte introductoria La lista de mercancías se representa en un cuadro, cuya columna número 1 incluye los nombres (descripción) de las mercancías, mientras que la columna número 2 incluye los códigos del SA ruso de los apartados en los que están incluidas. La clasificación de mercancías en las partidas específicas del SA ruso se realizará de conformidad con los criterios adoptados en el SA ruso y con las normas de interpretación del SA ruso. Cuando se utilice esta lista, las mercancías se denominarán exclusivamente por sus códigos del SA ruso y en aquellos casos en los que en la columna 2 "Códigos del SA ruso" aparezcan frases como "de...", además de los códigos del SA ruso indicados, se utilizarán como guía los nombres (descripciones) de las mercancías con respecto a las explicaciones dadas en las notas de este cuadro. _________________________________________________________________ ¦ Names (descriptions) of commodities ¦ Russian HS codes ¦ _________________________________________________________________________ ¦ 1 ¦ 2 ¦ _________________________________________________________________________ ¦Meat and edible meat offal*(1) ¦group 02 ¦ _________________________________________________________________________ ¦Fish and crustaceans, molluscs and other
    [Show full text]