UPDATES: VEM / NTD & STAG 2019

RAMAN VELAYUDHAN, VEM/NTD VCAG MEETING, 13 MAY 2019 GENEVA, SWITZERLAND

Vector Ecology & Management WHO Neglected Tropical Diseases 5 CORE STRATEGIES FOR CONTROL, ELIMINATION AND ERADICATION OF NTDs…

1. Preventive chemotherapy (2017) – 1.762 billion treatments delivered; 1.036 billion in need treated for at least one disease 2. Innovative and intensified disease management – > 462 000 people diagnosed and treated (2017) – Roll-out of WHO information System to Control and Eliminate NTDs (WISCENTD) – Scale-up of the integrated skin-NTD approach 3. ecology and management – Updating normative guidance and supporting implementation of GVCR 2017 ̶ 2030 – Preventing and controlling dengue/chikungunya and other Aedes-borne diseases – Investigating new tools for prevention and control of VBDs 4. Veterinary and One Health approaches – Reinforcing coordination with FAO, OIE and veterinary and authorities authorities 5. Water, and – Toolkit on WASH and Neglected Tropical Diseases released in 2019

Vector Ecology & Management 2 WHO Neglected Tropical Diseases VEM WORKS TO STOP NTDs SPREAD BY MOSQUITOES, FLIES (SAND-, BLACK-, TSETSE-), BUGS, TICKS, AND OTHER VECTORS

9 Neglected Tropical Diseases (NTDs) involve vector transmission: ➢dengue, chikungunya, disease, leishmaniasis, lymphatic filariasis, human African trypanosomiasis, , onchocerciasis, and schistosomiasis 600M annual cases among world's poorest populations Aedes-borne disease outbreaks show the growing threat vector-borne NTDs pose to societies

Vector Ecology & Management 3 WHO Neglected Tropical Diseases UPDATE ON VEM PROJECTS & COLLABORATIONS

SUPPORT 3 COUNTRIES 1 BUILD CAPACITY FOR 2 GLOBAL POLICIES • 9 Neglected Tropical Diseases RESEARCH & SURVEILLANCE • Pesticide • Capacity building for GLP • Global vector control management (IPCS) response 2017–2030: “World certification of labs (i2i) free of human suffering from • Ethics and Vector • Global laboratory vector-borne diseases” borne diseases proficiency testing (IHR) Guidance • Reduce the burden and Framework for SIT- • Collaborating institutions threat of dengue globally Aedes (IAEA / TDR)

4 INNOVATION & VECTOR SUPPORT EMERGENCY 5 CONTROL RESPONSE • New Vector Control Tools for • Core capacities for vector NTDs – VCAG control at PoE • M&E of -Aedes • Vector Identification at PoE pilots (PAHO) & Safety of Wolbachia-Aedes • Aircraft disinsection methods • Horizon scanning for VC tools and procedures

Vector Ecology & Management 4 WHO Neglected Tropical Diseases Supporting countries in Aedes-borne diseases Progress • >50% case decline (2017 ̶ 2018) in the Americas post-Zika outbreak • Global decline in case fatality rate • Burden estimation toolkit developed; 10 countries assessed Challenges • 128 endemic countries, 3.6 billion at risk of infection, 50 ̶ 100 M cases/year • Rise in number and size of urban areas Opportunities • New vector control tools, potential vaccines, integrated & intersectoral approach • Regional plans and country activities based on GVCR • Vector surveillance and M&E

Vector Ecology & Management 5 WHO Neglected Tropical Diseases 4 3 New Vector Control Tools for NTDs

POLICY SUPPORT FOR INNOVATION Intervention Disease target Prototype / product COUNTRIESStatus & VECTOR CONTROL Spatial Repellents Dengue /arboviral Transfluthrin passive emanator Epi Peridomestic residual spray Dengue /arboviral Spaying of exterior walls and Epi boundary fences of dwellings with residual formulations Vector traps for disease Dengue /arboviral Vector traps including AGO trap Epi management and Trap-N-kill ® trap Dengue /arboviral In2Care® Trap Epi Genetic manipulation of Dengue /arboviral Next generation product --- vectors for disease control

Sterile technique with Dengue /arboviral Sterilized male Ae. aegypti and Ae. Epi microbial infection albopictus infected with Wolbachia Microbial control of human Dengue /arboviral wMel strain Wolbachia in Aedes Epi in adult vectors aegypti Systemic and Leishmaniasis / sandfly Fipronil bolus Epi endectocides Vector Ecology & Management 6 WHO Neglected Tropical Diseases OUTCOMES OF STAG 2019 TOWARDS 2030: NEW NTD ROADMAP

The new NTD Roadmap 2021 ̶ 2030 will be: – the outcome of a wide consultative process – country-centric – focused towards 2030 while building on progress of the 2020 NTD Roadmap – aligned with the UN Sustainable Development Goals and WHO’s GPW13 – cross-cutting – launched in October 2020

Two overarching goals ̶ disease-specific targets ̶ cross- cutting indicators

Vector Ecology & Management 7 WHO Neglected Tropical Diseases NTDs in the development context

–NTD Road map –New NTD Road map –GPW 13 –UN Sustainable Development Goals 201 201 202 202 202 202 202 202 202 202 202 202 203 8 9 0 1 2 3 4 5 6 7 8 9 0

–“The triple billion”

Vector Ecology & Management 8 WHO Neglected Tropical Diseases Revision and updates

Vector Ecology & Management 9 WHO Neglected Tropical Diseases OUTCOMES OF STAG 2019: Vector-borne diseases

Urban environments (especially informal settlements) facilitate the spread of A. aegypti and associated arboviral infections, and the NTD department should facilitate cross- sectoral action, working with appropriate actors.

The NTD Department should work closely with appropriate actors to address the issues of NTD medicine and insecticide resistance.

Technical WGs that report to the Director NTDs to include dengue and arbovirus control

Vector Ecology & Management 10 WHO Neglected Tropical Diseases Please log in and participate in the WHO global consultation on NTD roadmap:- https://www.who.int/neglected_diseases/news/WHO- launches-global-consultations-for-new-NTD- Roadmap/en/

Thank you

Vector Ecology & Management 11 WHO Neglected Tropical Diseases