N-Bromosuccinimide - Wikipedia
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Nomination Background: Methylal (CASRN: 109-87-5)
SUMMARY OF DATA FOR CHEMICAL SELECTION METHYLAL CAS NO. 109-87-5 BASIS OF NOMINATION TO THE CSWG The nomination of methylal to the CSWG is based on high production volume and exposure potential. Dr. Elizabeth Weisburger, a member of the American Conference of Governmental Industrial Hygienists (ACGIH) TLV Committee as well as the Chemical Selection Working Group (CSWG), provided a list of 281 chemical substances with ACGIH recommended TLVs for which there were no long term studies cited in the supporting data and no designations with respect to carcinogenicity. She presented the list to the Chemical Selection Planning Group (CSPG) for evaluation as chemicals which may warrant chronic testing: it was affirmed at the CSPG meeting held on August 9, 1994, that the 281 "TLV Chemicals" be reviewed as a Class Study. As a result of the class study review, methylal is presented as a candidate for testing by the National Toxicology Program because of: • potential for occupational exposures based on high production volume (1.2-64 million lbs) and estimate of worker exposure • evidence of occupational exposures based on TLV and other literature documentation • potential for general population exposures based on use as a solvent in consumer products and occurrence in environmental media • suspicion of carcinogenicity based on potential for metabolic release of formaldehyde and positive mutagenicity data • lack of chronic toxicity data. SELECTION STATUS ACTION BY CSWG : 9/25/96 Studies requested : - Carcinogenicity Priority : Moderate to High Rationale/Remarks : - Potential for human exposure - Inhalation route recommended for testing - Consider transgenic mouse model (p53 or TGAC) INPUT FROM GOVERNMENT AGENCIES/INDUSTRY Dr. -
Hydantoin and Succinimide-Substituted
(1 9) J Eur°Pean Patent Office <*S Office europeen des brevets (11) EP 0 533 243 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) int. CI.6: C07D 401/1 2, C07D 471/10, of the grant of the patent: A61 K 31/445 Q07D 401 /1 4 17,2,997 Buiietin 1997/51 // (C07D471/1 0, 235:00, (21) Application number: 92202723.0 221:00) (22) Date of filing: 08.09.1992 (54) Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten Derives de spiroindanylcamphorsulfonyl substitues par un radical hydantoine ou succinimide comme antagonists d'oxytocine (84) Designated Contracting States: (74) Representative: CH DE FR GB IT LI NL Thompson, John Dr. et al Merck & Co., Inc. (30) Priority: 16.09.1991 US 760416 European Patent Department Terlings Park (43) Date of publication of application: Eastwick Road 24.03.1993 Bulletin 1993/12 Harlow, Essex CM20 2QR (GB) (73) Proprietor: Merck & Co., Inc. (56) References cited: Rahway New Jersey 07065-0900 (US) EP-A- 0 444 945 EP-A- 0 445 974 EP-A- 0 450 761 EP-A- 0 486 280 (72) Inventors: US-A- 3 654 287 • Gilbert, Kevin Bally, PA 19503 (US) • EP-A- 0 444 945 • Williams, Peter D. • EP-A- 0 445 974 Harleysville, PA 19438 (US) • EP-A- 0 450 761 • Hobbs, Doug W. • EP-A- 0 486 280 Lansdale, PA 19446 (US) • US-A- 3 654 287 • Evans, Ben E. Lansdale, PA 19446 (US) Remarks: • Veber, Daniel F. The file contains technical information submitted Ambler, PA 19002 (US) after the application was filed and not included in this specification CO CO CM CO CO Note: Within nine months from the publication of the mention of the grant of the European patent, give IO any person may notice to the European Patent Office of opposition to the European patent granted. -
Cyclopentyl Methyl Ether (CPME)
Korean J. Chem. Eng., 34(2), 463-469 (2017) pISSN: 0256-1115 DOI: 10.1007/s11814-016-0265-5 eISSN: 1975-7220 INVITED REVIEW PAPER Measurement and correlation of the isothermal VLE data for the binary mixtures of cyclopentene (CPEN)+cyclopentyl methyl ether (CPME) Wan Ju Jeong and Jong Sung Lim† Department of Chemical and Biomolecular Engineering, Sogang University, C.P.O. Box 1142, Seoul 04107, Korea (Received 2 August 2016 • accepted 20 September 2016) Abstract−The isothermal vapor-liquid equilibrium data for the binary systems of cyclopentene (1)+cyclopentyl methyl ether (2) were measured at 313.15, 323.15, 333.15, 343.15 and 353.15 K using a dynamic-type equilibrium apparatus and online gas chromatography analysis. For all the measured VLE data consistency tests were performed for the verifi- cation of data using Barker’s method and the ASPEN PLUS Area Test method. All the resulting average absolute val- δ γ γ ues of residuals [ ln ( 1/ 2)] for Barker’s method and D values for the ASPEN PLUS area test method were com- paratively small. So, the VLE data reported in this study are considered to be acceptable. This binary system shows neg- ative deviation from Raoult’s law and does not exhibit azeotropic behavior at whole temperature ranges studied here. The measured data were correlated with the P-R EoS using the Wong-Sandler mixing rule. The overall average relative deviation of pressure (ARD-P (%)) between experimental and calculated values was 0.078% and that of vapor phase compositions (ARD-y (%)) was 0.452%. Keywords: Vapor Liquid Equilibria (VLE), Cyclopentyl Methyl Ether (CPME), Cyclopentene (CPEN), Peng-Robinson Equation of State (PR-EoS), Wong-Sandler Mixing Rule (WS-MR) INTRODUCTION however, have some disadvantages because they use dimethyl sul- fate and methyl iodide as a reactant, respectively, which are muta- Ethers are widely used in organic chemistry and biochemistry. -
Calcium Channel Blocker As a Drug Candidate for the Treatment of Generalised Epilepsies
UNIVERSITAT DE BARCELONA Faculty of Pharmacy and Food Sciences Calcium channel blocker as a drug candidate for the treatment of generalised epilepsies Final degree project Author: Janire Sanz Sevilla Bachelor's degree in Pharmacy Primary field: Organic Chemistry, Pharmacology and Therapeutics Secondary field: Physiology, Pathophysiology and Molecular Biology March 2019 This work is licensed under a Creative Commons license ABBREVIATIONS AED antiepileptic drug AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ANNA-1 antineuronal nuclear antibody 1 BBB blood-brain barrier Bn benzyl BnBr benzyl bromide BnNCO benzyl isocyanate Boc tert-butoxycarbonyl Bu4NBr tetrabutylammonium bromide Ca+2 calcium ion CACNA1 calcium channel voltage-dependent gene cAMP cyclic adenosine monophosphate CCB calcium channel blocker cGMP cyclic guanosine monophosphate CH3CN acetonitrile Cl- chlorine ion Cmax maximum concentration CMV cytomegalovirus CTScan computed axial tomography DCM dichloromethane DIPEA N,N-diisopropylethylamine DMF dimethylformamide DMPK drug metabolism and pharmacokinetics DNET dysembryoplastic neuroepithelial tumours EEG electroencephalogram EPSP excitatory post-synaptic potential FDA food and drug administration Fe iron FLIPR fluorescence imaging plate reader fMRI functional magnetic resonance imaging GABA γ-amino-α-hydroxybutyric acid GAD65 glutamic acid decarboxylase 65 GAERS generalised absence epilepsy rat of Strasbourg GluR5 kainate receptor GTC generalised tonic-clonic H+ hydrogen ion H2 hydrogen H2O dihydrogen dioxide (water) -
A Coniparative Evaluation of Operating Conditions for the Electrochemical Bromination and Chlorination of Succinimide
Bulletin of Electrochemistry 16 (12) December 2000, pp 544-550 0256-1654/2000/$ 3-50 © 2000 CECRI • A CONIPARATIVE EVALUATION OF OPERATING CONDITIONS FOR THE ELECTROCHEMICAL BROMINATION AND CHLORINATION OF SUCCINIMIDE S KRISHNAMOORTHY, R KANAKAM SRINIVASAN AND M NOEL Central Electrochemical Research Institute, Karaikudi 630 006. INDIA [Received: 20 September 1998 Accepted: 19 September 2000] Platinum was found to be the electrode of choice for both electrochlorination and bromination of succinimide leading to the formation of N chloro succinimide (NCS) and N bromo succinimide (NBS) respectively. Because of the competitive processes 150% and 285% of theoretical charge has to be passed for bromination and chlorination respectively. 12% (w!v) of succinimide could be used for bromination while only 2% (w!v) of this reactant is optimum for chlorination. Optimum conditions have been evaluated for the process. A maximum yield of 55% and 88% could be achieved for bromination and chlorination of succinimide respectively. Keywords: •Chlorination, bromination succinimide INTRODUCTION A thermostated closed glass vessel with provIsions for working electrode (platinum, graphite, TSIA and GSLD) Probably because of the facile bromination [1-4] and [14-15], counter electrode, platinum (4 x 3 ems) chlorination [5-9] of succinimide (SI) by chemical means, thermometer and a glass stirrer was used as the the corresponding electrohalogenation process have not preparative cell. received considerable attention. A brief report on the After completion of electrolysis, NCS and NBS are preparation of N- bromosuccinimide (NBS) in aqueous separated by filtration and washed with a cold (275 K) sodium bromide solution on platinum electrode is saturated solution of the corresponding N-halosuccinimide. -
Synthesis of 2-Substituted Benzimidazole-5-Carbamates As 1109 Potential Antifilarial Agents Siya Ram, Dean S
Jul-Aug 1986 Synthesis of 2-Substituted Benzimidazole-5-carbamates as 1109 Potential Antifilarial Agents Siya Ram, Dean S. Wise and Leroy B. Townsend* Department of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1065 Received August 26, 1985 A number of 2,5-disubstituted benzimidazoles have been prepared from 2-benzyl-5-nitrobenzimidazole (5) and 2-p-fluorobenzyl-5-nitrobenzimidazole(6), and evaluated as potential antifilarial agents. None of the compounds prepared in this study have demonstrated any significant antifilarial activity. J. Heterocyclic Chem.. 23, 1109 (1986). A large group of benzimidazole derivatives are highly effective as an anthelmintics [ 11. Among these, meben- dazole (la, methyl 5-benzoylbenzimidazole-2-carbamate) and flubendazole (lb, methyl 5-p-fluorobenzoylbenzimida- 5. x-H zole-Z-carbamate) have demonstrated a broad-spectrum of 6, X-F activity against helminth diseases including filarial infec- 4.. XZH tions [2-51. In our continuing studies to develop new an- b. X=F tifilarial agents [6-81, we have found that two of the metabolites of mebendazole, methyl 5-(c~-hydroxylbenzyl)- 0 I benzimidazole-2-carbamate (lc), and, methyl 5-benzyl- benzimidazole-2-carbamate (la)possess antifilarial activi- ty very similar to that of the parent drug la [9]. Recently, a 9.X:H. R:CH, 10, X= F . R -CH, series of benzothiazoles, typified by structure 2, were 11, X=H. R-C,H, I 7, XzH I c:o taco, I CH,OH OR / reported to possess both micro- and macrofilarial activity against B. pahangi [lo]. -
Guidance Document Peroxide-Forming Chemicals
Guidance Document Peroxide-Forming Chemicals Some chemicals can form peroxides under normal storage conditions. Some of the peroxide chemicals are unstable, especially when dried or concentrated, and can explode violently when subjected to heat, light or mechanical shock. In addition, some of the inadvertently formed peroxides can initiate other unexpected violent reactions (e.g. polymerizations) with other chemicals. When possible and practical for your work, purchase chemicals that have inhibitors added by the manufacturer. Label peroxide-forming chemicals with date received and date opened. Store peroxide-formers in airtight opaque containers with screw caps. Consider oxygen exclusion methods such as purging with inert gas or sealing containers with parafilm. Inspect containers for signs of peroxide formation. Do not open a container which has crystals or a visible cloudiness. Call EHS to come remove it. The friction caused by opening a lid can cause an explosion. Liquids can be tested for presence of peroxide. This is especially important prior to distilation. Most explosions of peroxide forming chemicals occur when a material is distilled to dryness. Peroxide test kits are available from chemical vendors. Contact EHS for additional guidance. Classification Table for Peroxide-Forming Chemicals Class I:: Unsaturated materials, especially those of low molecular weight, may polymerize violently and hazardously due to peroxide initiation. These chemicals can spontaneously decompose, becoming explosive after exposure to air with concentration. Discard unopened containers within 3 months. Opened containers should be tested for peroxides every 2 months. Acrylic acid Tetrafluoroethylene Acrylonitrile Vinyl acetate 1,3-Butadiene Vinyl acetylene Chlorobutadiene (chloroprene) Vinyl chloride Chlorotrifluoroethylene Vinyl pyridine Methyl methacrylate Vinylidiene chloride Styrene Class II: The following chemicals are a peroxide hazard upon concentration (distillation/evaporation). -
NMR Chemical Shifts of Common Laboratory Solvents As Trace Impurities
7512 J. Org. Chem. 1997, 62, 7512-7515 NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities Hugo E. Gottlieb,* Vadim Kotlyar, and Abraham Nudelman* Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel Received June 27, 1997 In the course of the routine use of NMR as an aid for organic chemistry, a day-to-day problem is the identifica- tion of signals deriving from common contaminants (water, solvents, stabilizers, oils) in less-than-analyti- cally-pure samples. This data may be available in the literature, but the time involved in searching for it may be considerable. Another issue is the concentration dependence of chemical shifts (especially 1H); results obtained two or three decades ago usually refer to much Figure 1. Chemical shift of HDO as a function of tempera- more concentrated samples, and run at lower magnetic ture. fields, than today’s practice. 1 13 We therefore decided to collect H and C chemical dependent (vide infra). Also, any potential hydrogen- shifts of what are, in our experience, the most popular bond acceptor will tend to shift the water signal down- “extra peaks” in a variety of commonly used NMR field; this is particularly true for nonpolar solvents. In solvents, in the hope that this will be of assistance to contrast, in e.g. DMSO the water is already strongly the practicing chemist. hydrogen-bonded to the solvent, and solutes have only a negligible effect on its chemical shift. This is also true Experimental Section for D2O; the chemical shift of the residual HDO is very NMR spectra were taken in a Bruker DPX-300 instrument temperature-dependent (vide infra) but, maybe counter- (300.1 and 75.5 MHz for 1H and 13C, respectively). -
(12) United States Patent (10) Patent No.: US 7.449,439 B2 to Et Al
USOO7449439B2 (12) United States Patent (10) Patent No.: US 7.449,439 B2 to et al. (45) Date of Patent: Nov. 11, 2008 (54) WATER-SOLUBLE THICKENER AND LIQUID (56) References Cited ACDIC DETERGENT U.S. PATENT DOCUMENTS (75) Inventors: Kenji Ito, Aichi (JP); Yoshio Mori, 3,768,565 A 10, 1973 Persinski et al. Aichi (JP) (Continued) (73) Assignee: Toagosei Co., Ltd., Tokyo (JP) FOREIGN PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this JP 53-463O2 A 4f1978 patent is extended or adjusted under 35 U.S.C. 154(b) by 455 days. (Continued) (21) Appl. No.: 10/530,179 OTHER PUBLICATIONS International Search Report PCT/JP2003/012764 dated Dec. 9, 2003. (22) PCT Filed: Oct. 6, 2003 (Continued) (86). PCT No.: PCT/UP03/12764 Primary Examiner Brian PMruk S371 (c)(1), (74) Attorney, Agent, or Firm Sughrue Mion, PLLC (2), (4) Date: Apr. 4, 2005 (57) ABSTRACT (87) PCT Pub. No.: WO2004/031314 A water-soluble thickener which is highly effective even in PCT Pub. Date: Apr. 15, 2004 thickening strongly acidic aqueous Solutions and has excel lent stability in such solutions. It comprises a water-soluble (65) Prior Publication Data copolymer having a weight-average molecular weight of 6,000,000 or higher obtainable by polymerizing a monomer US 2006/OO46949 A1 Mar. 2, 2006 mixture which comprises 2-acrylamido-2-methylpropane (30) Foreign Application Priority Data Sulfonic acid and/or a salt thereofandacrylic acid and/or a salt thereofas essential components and optionally one or more Oct. 4, 2002 (JP) ............................. 2002-292975 other copolymerizable monomer components including the Oct. -
A Novel Nonphosgene Process for the Synthesis of Methyl Nphenyl
Chinese Journal of Chemistry, 2004.22.782-786 Article A Novel Non-phosgene Process for the Synthesis of Methyl N-Phenyl Carbamate from Methanol and Phenylurea: Effect of Solvent and Catalyst WANG, Xin-Kuia(3/l&S) YAN, Shi-Run'vb(/q@%d) CAO, Yong*(g!F!) FAN, Kang-Nian'pb(3i5@+) HE,He-Yongb(W@B!) KANG, Mao-Qing"(fiit$W) PENG, Shao-Yia(G9B) a Institute of Coal Chemistty Chinese Academy of Sciences, Taiyuan, Shami 030001, China b Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Deparfment of Chemistv, Fudan University, Shanghai 200433. China A novel environmentally benign process for the synthesis of methyl N-phenyl carbamate (Mpc) from methanol and phenylurea was studied. Effect of solvent and catalyst on the reaction behavior was investigated. The IR spectra of methanol and phenylurea dissolved in different solvents were also recorded. Compared with use of methanol as both a reactant and a solvent, phenylurea conversion and selectivity to Mpc increased by using toluene, benzene or anisole as a solvent, while phenylurea conversion decreased slightly by using n-octane as a solvent. The phenylurea conversion declined nearly 50% when dimethyl sulfoxide (DMSO) was used as a reaction media, and MPC selec- tivity decreased as well. The catalytic reaction tests showed that a basic catalyst enhanced the selectivity to Mpc while an acidic catalyst promoted the formation of methyl carbamate and aniline. Moderate degree of basicity showed the best catalyhc performance in the cases studied. Keywords methyl N-phenyl carbamate synthesis, phenylurea, phosgene-free, solvent effect, acid-base catalyst Introduction tion of methanol from DMC azeotrope, and DMC is relatively expensive. -
Estonian Statistics on Medicines 2016 1/41
Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole -
Sure/Seal™ System for Anhydrous Solvents
QUALITY AND SAFETY. SEALED. Sure/Seal™ system for anhydrous solvents The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada. Choose from the largest range of high-quality anhydrous solvents Innovative plug style with exceptionally low water levels. • Maximum surface area contact (liner to bottle) to exclude Rest assured that each product moisture and oxygen is perfectly protected with our innovative, moisture-inhibiting • More than 50% thicker than competing brands to ensure low Sure/Seal™ system. We use three water content for entire shelf life different types of materials to ensure complete compatibility with Outstanding elastomer and crimp cap design contents, and easier handling for you. Sure/Seal™ bottles come in • Air-tight system to protect product quality several sizes, ranging from 100 mL • Excellent resealing properties to 2 L. • Secondary resin layer ensures resistance to chemicals • Outperforms competitors’ seals in moisture prevention • Three unique plug-style liners to suit a wide range of solvents and solutions Highest quality anhydrous solvents • Always maintains exceptionally low water content • More than 90 products in different categories, including common air and/or moisture-sensitive, volatiles, and strong odors • Various size offerings, from 100 mL to 2 L (Larger size of one- way container also available in North America) Three unique plug-style liners created for optimal compatibility with various solvents White liner for Hexane, Toluene, Dichloromethane Gray