Madurella Mycetomatis

Karrakchou et al. BMC Dermatology (2020) 20:1 https://doi.org/10.1186/s12895-019-0097-1 CASE REPORT Open Access Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region Basma Karrakchou* , Ibtissam Boubnane, Karima Senouci and Badreddine Hassam Abstract Background: Mycetoma is an uncommon chronic granulomatous infection of cutaneous and subcutaneous tissues that can be caused by filamentous bacteria (actinomycetoma) or fungi (eumycetoma). It is the prerogative of young men between the third and fourth decade and is transmitted through any trauma causing an inoculating point. The classic clinical triad associates a painless hard and swelling subcutaneous mass, multiple fistulas, and the pathognomonic discharge of grains. Although endemic in many tropical and subtropical countries, mycetoma can also be found in non-endemic areas as in Morocco, and causes then diagnosis problems leading to long lasting complications. Therefore, we should raise awareness of this neglected disease for an earlier management. Under medical treatment however, mycetoma has a slow healing and surgery is often needed, and relapses are possible. Case presentation: Herein we report a case of a 64 years old patient, with a history of eumycetoma occurring ten years ago treated with oral terbinafine coupled with surgery. A complete remission was seen after 2 years. He presented a relapse on the previous scar 6 months ago. There wasn’t any bone involvement in the magnetic resonance imaging (MRI). The patient was put under oral terbinafine with a slow but positive outcome. Conclusion: Through this case report, we perform a literature review and highlight the importance of increase awareness of mycetoma in clinical practice especially in non-endemic regions. Keywords: Madurella mycetomatis, Mycetoma, Actinomycetoma, Eumycetoma, Neglected disease Background regions with low rainfall [3, 6]. Therefore, mycetoma is en- Mycetoma is a chronic granulomatous infection of cutane- demic in many countries in the tropics and subtropics [3], ous and subcutaneous tissues that can be caused by fila- but little known in other countries including Morocco mentous bacteria (actinomycetoma) or fungi (eumycetoma) where they prevail in sporadic forms and cause diagnostic [1]. It occurs typically in young men between 20 and 40 problems [7]. years old, and is the prerogative of farmers who are ex- In this work, a case of eumycetoma of the foot in a posed to contaminated soil during minor injuries in most Moroccan patient was reported, and literature review cases [2]. Clinically, mycetoma or « Madura foot » is an was provided. inflammatory tumor, often polyfistulised, evolving in a chronic mode. Its fistulas give rise to grains whose color di- Case presentation rects towards the causative germ [3, 4]. Although the true Our patient is a 64 years old man from Sidi Slimane in incidence of mycetoma remains uncertain, 60% of myce- the center of Morocco where he currently lives and toma are bacterial and 40% are fungal [5]. And most of the works as a farmer. He is married and has five children in cases fall between latitude 15°S and 30°N, the so-called good health. He presented ten years ago a history of a “mycetoma belt” characterized by warm, dry, semi-desert nodule located in the dorsal surface of his right forefoot, which has progressively increased in size until becoming a swelling and slightly painful polyfistulised tumor emit- * Correspondence: [email protected] Dermatology and Venereology Department, Ibn Sina Hospital, Mohammed V ting dark grains. No previous trauma or injury of the University, Rabat, Morocco foot has been noticed by the patient and no travel to © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Karrakchou et al. BMC Dermatology (2020) 20:1 Page 2 of 7 endemic zone in Africa or outside Africa has been re- On the other hand, several differential diagnoses of myce- ported. He was hospitalized in the Dermatology depart- toma such as cutaneous tuberculosis, profound mycosis, fis- ment of the University Hospital Ibn Sina of Rabat, and tulised osteitis, leprosy, and cutaneous metastatic lesions the diagnosis of eumycetoma due to Madurella myceto- were considered. Complementary examinations showed a matis was detected. The patient was initially treated with normal aspect on foot X-rays. The biological assessment oral itraconazole at a dosage of 400 mg/day during 2 didn’t show any signs of bacterial infection. A biopsy was years. After antifungal treatment, the lesions did not im- performed and during this procedure, a serohematic dis- prove substantially and itraconazole was substituted by charge was witnessed with conglomerates of small and firm terbinafine 500 mg/day, associated with surgical debride- blackish pellets, evoking eumycetoma (Fig. 1). Tissue and ment of the tumor. The outcome was good with total black grain samples were analyzed for bacterial, mycological healing of the lesions, and treatment with terbinafine and histological evaluation. The anatomopathological as- was continued to achieve a total length of 6 months. pect showed a polymorphic inflammatory cell reaction. The The current history goes back to 6 months by the bacterial analysis was negative, and the mycological study appearance of a nodule localized on the previous scar, revealed on direct examination septated hyphae containing having the same evolution than the previous one. On numerous chlamydoconidia measuring 2 to 5 μmindiam- physical examination, he had an indurated inflammatory eter with terminal dilatations giving a vesicle appearance tumor of the dorsal surface of the right forefoot, measur- (Fig. 2). The fungal culture on Sabouraud media established ing 15x10cm, adherent to the skin and to deep structures, the diagnosis of certainty and identified Madurella myceto- with many visible openings, which let emerge seropuru- matis after 3 weeks of growth (Fig. 3). A magnetic reson- lent sometimes hematic fluid and small black grains of 1 ance imaging of the right foot was performed to determine to 2 mm (Fig. 1). Moreover, inflammatory inguinal lymph- the lesions extension. This examination identified multiple adenopathy was found in the right side, and macerated collections of the right forefoot soft tissues, fusing along ex- toes intertrigos were present in the right foot. Further- tensor and flexor tendons without associated joint or bone more, there was no fever or alteration of the general invasion (Fig. 4). A treatment with oral terbinafine at a dos- condition. age of 750 mg/day for at least 1 year was started because of its previous efficiency in our patient. We performed monthly liver function tests (liver transaminases) to assess treatment tolerability. Within 6 months, the lesions evolution was slow with a fistulas drying up, and no liver damage was noted. Fig. 2 Direct examination of black grains under optical microscopy × 40 (Parasitology and Mycology Department, Ibn Sina Hospital, Rabat). Evocative aspect of Madurella mycetomatis: thick septated Fig. 1 Mycetoma of the right forefoot with polyfistulas emitting and branched hyphae (red arrow), ending in vesicles corresponding serohematic fluid and dark grains (arrow) to circular chlamydoconidia (black arrow) Karrakchou et al. BMC Dermatology (2020) 20:1 Page 3 of 7 intermittent short periods of rainfall. These zones are called “mycetoma belt” and they include Mauritania, Senegal, Chad, Sudan, Ethiopia, Somalia, Yemen, India, Thailand, Mexico, and the Bolivarian Republic of Venezuela. Therefore the World Health Organization approved (May 2016) a resolution (WHA69.21) recog- nizing mycetoma as a neglected tropical disease because of its endemicity in poor populations living in remote areas of developing countries [1]. However, some sporadic autochthone cases have been described in temper- ate zones such as in the Maghreb, where the disease incidence is rare, as in Morocco, causing diagnosis problems. Mycetoma is the prerogative of young adults, mostly men between the third and fourth decade with a sex ratio of 4/1 [5]. The transmission is done via a contact with a Fig. 3 Microscopic aspect of Madurella mycetomatis’ colony colored contaminated soil through a thorn prick or any trauma with Lactophenol Cotton Blue Stain × 40 (Parasitology and Mycology causing an inoculating point [1]. However, the infection is Department, Ibn Sina Hospital, Rabat) not transmitted from one person to another. Therefore, mycetoma is found generally in rural areas and affects manual workers or those who walk barefoot, such as Discussion and conclusions farmers, laborers, and herdsmen. Furthermore, our patient Mycetoma was first reported in 1843 by Dr. John Gill in corresponds to the description of the persons at risk to de- Madurai, India [8] and was then called “Madura foot”.It velop the disease in view of his sex, origin, and work. is a chronic granulomatous infection of cutaneous and The classic clinical triad associating a painless hard subcutaneous tissues that can be caused by filamentous and swelling subcutaneous mass, multiple fistulas, and bacteria (actinomycetoma) or fungi (eumycetoma) [1]. discharge of grains characterizes mycetoma. The foot is Indeed, a bacterial origin is found in 60%, whereas fungi the most common site of involvement, as seen in our pa- are responsible of 40% of cases reported worldwide [2]. tient and as indicated by the denomination “Madura Moreover, causative bacterial agents are more numerous foot” [10]. Nonetheless, all other parts of the body can than fungal agents (only four agents reported) [9] be affected such as the arm, forearm, hand, back, thorax, (Table 1).

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