Invasive Aspergillosis by Aspergillus Flavus
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Allergic Bronchopulmonary Aspergillosis Revealing Asthma
CASE REPORT published: 22 June 2021 doi: 10.3389/fimmu.2021.695954 Case Report: Allergic Bronchopulmonary Aspergillosis Revealing Asthma Houda Snen 1,2*, Aicha Kallel 2,3*, Hana Blibech 1,2, Sana Jemel 2,3, Nozha Ben Salah 1,2, Sonia Marouen 3, Nadia Mehiri 1,2, Slah Belhaj 3, Bechir Louzir 1,2 and Kalthoum Kallel 2,3 1 Pulmonary Department, Hospital Mongi Slim, La Marsa, Tunisia, 2 Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia, 3 Parasitology and Mycology Department, La Rabta Hospital, Tunis, Tunisia Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus which colonizes the airways of patients with asthma and cystic fibrosis. Its diagnosis could be difficult in some cases due to atypical Edited by: presentations especially when there is no medical history of asthma. Treatment of ABPA is Brian Stephen Eley, frequently associated to side effects but cumulated drug toxicity due to different molecules University of Cape Town, South Africa is rarely reported. An accurate choice among the different available molecules and Reviewed by: effective on ABPA is crucial. We report a case of ABPA in a woman without a known Shivank Singh, Southern Medical University, China history of asthma. She presented an acute bronchitis with wheezing dyspnea leading to an Richard B. Moss, acute respiratory failure. She was hospitalized in the intensive care unit. The Stanford University, United States bronchoscopy revealed a complete obstruction of the left primary bronchus by a sticky *Correspondence: Houda Snen greenish material. The culture of this material isolated Aspergillus fumigatus and that of [email protected] bronchial aspiration fluid isolated Pseudomonas aeruginosa. -
Characterization of Aspergillus Flavus Soil and Corn Kernel Populations from Eight Mississippi River States Jorge A
Louisiana State University LSU Digital Commons LSU Master's Theses Graduate School 11-13-2017 Characterization of Aspergillus Flavus Soil and Corn Kernel Populations From Eight Mississippi River States Jorge A. Reyes Pineda Louisiana State University and Agricultural and Mechanical College, [email protected] Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_theses Part of the Agricultural Science Commons, Agriculture Commons, and the Plant Pathology Commons Recommended Citation Reyes Pineda, Jorge A., "Characterization of Aspergillus Flavus Soil and Corn Kernel Populations From Eight Mississippi River States" (2017). LSU Master's Theses. 4350. https://digitalcommons.lsu.edu/gradschool_theses/4350 This Thesis is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Master's Theses by an authorized graduate school editor of LSU Digital Commons. For more information, please contact [email protected]. CHARACTERIZATION OF ASPERGILLUS FLAVUS SOIL AND CORN KERNEL POPULATIONS FROM EIGHT MISSISSIPPI RIVER STATES A Thesis Submitted to the Graduate Faculty of the Louisiana State University Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Master of Science in The Department of Plant Pathology and Crop Physiology by Jorge A. Reyes Pineda B.S., Universidad Nacional de Agricultura-Honduras 2011 December 2017 ACKNOWLEDGEMENTS I first thank God who gave me the strength and perseverance to complete the requirements for this degree, and second, I thank my family. Without their unconditional support and encouragement, I would have never been able to achieve this endeavor. I would like to thank my advisory committee, Drs. -
Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Aberdeen University Research Archive Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis. Adilia Warris, MD PhD MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK. Corresponding address: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD, Aberdeen, UK. Phone: +44 (0)1224437596. Fax: +44 (0)1224437506. E-mail: [email protected] Acknowledgements AW is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen. Key Words: chronic granulomatous disease, cystic fibrosis, Aspergillus, aspergillosis, inflammation Abbreviated title: Aspergillus infections in CGD and CF Running head title: Aspergillus infections in CGD and CF Introduction Children with chronic granulomatous disease (CGD) and cystic fibrosis (CF) share some important clinical characteristics which are the consequence of their intrinsic susceptibility to recurrent and opportunistic infections and exaggerated inflammation. Although the clinical phenotypes of Aspergillus disease differ substantially between those two non-neutropenic patient groups, the underlying pathophysiology show remarkable commonalities with excessive inflammation being a hallmark of Aspergillus disease. The occurrence of Aspergillus infections in these two patient populations is associated with decreased quality of life and premature death. Our knowledge of the pathophysiology of Aspergillus infections is mainly derived from infections caused by a single species - Aspergillus fumigatus - in the neutropenic host. The insights obtained in this setting do not translate well to the non-neutropenic host. -
Allergic Bronchopulmonary Aspergillosis and Severe Asthma with Fungal Sensitisation
Allergic Bronchopulmonary Aspergillosis and Severe Asthma with Fungal Sensitisation Dr Rohit Bazaz National Aspergillosis Centre, UK Manchester University NHS Foundation Trust/University of Manchester ~ ABPA -a41'1 Severe asthma wl'th funga I Siens itisat i on Subacute IA Chronic pulmonary aspergillosjs Simp 1Ie a:spe rgmoma As r§i · bronchitis I ram une dysfu net Ion Lun· damage Immu11e hypce ractivitv Figure 1 In t@rarctfo n of Aspergillus Vliith host. ABP A, aHerg tc broncho pu~ mo na my as µe rgi ~fos lis; IA, i nvas we as ?@rgiH os 5. MANCHl·.'>I ER J:-\2 I Kosmidis, Denning . Thorax 2015;70:270–277. doi:10.1136/thoraxjnl-2014-206291 Allergic Fungal Airway Disease Phenotypes I[ Asthma AAFS SAFS ABPA-S AAFS-asthma associated with fu ngaIsensitization SAFS-severe asthma with funga l sensitization ABPA-S-seropositive a llergic bronchopulmonary aspergi ll osis AB PA-CB-all ergic bronchopulmonary aspergi ll osis with central bronchiectasis Agarwal R, CurrAlfergy Asthma Rep 2011;11:403 Woolnough K et a l, Curr Opin Pulm Med 2015;21:39 9 Stanford Lucile Packard ~ Children's. Health Children's. Hospital CJ Scanford l MEDICINE Stanford MANCHl·.'>I ER J:-\2 I Aspergi 11 us Sensitisation • Skin testing/specific lgE • Surface hydroph,obins - RodA • 30% of patients with asthma • 13% p.atients with COPD • 65% patients with CF MANCHl·.'>I ER J:-\2 I Alternar1a• ABPA •· .ABPA is an exagg·erated response ofthe imm1une system1 to AspergUlus • Com1pUcatio n of asthm1a and cystic f ibrosis (rarell·y TH2 driven COPD o r no identif ied p1 rior resp1 iratory d isease) • ABPA as a comp1 Ucation of asth ma affects around 2.5% of adullts. -
Ergot Alkaloid Biosynthesis in Aspergillus Fumigatus : Association with Sporulation and Clustered Genes Common Among Ergot Fungi
Graduate Theses, Dissertations, and Problem Reports 2009 Ergot alkaloid biosynthesis in Aspergillus fumigatus : Association with sporulation and clustered genes common among ergot fungi Christine M. Coyle West Virginia University Follow this and additional works at: https://researchrepository.wvu.edu/etd Recommended Citation Coyle, Christine M., "Ergot alkaloid biosynthesis in Aspergillus fumigatus : Association with sporulation and clustered genes common among ergot fungi" (2009). Graduate Theses, Dissertations, and Problem Reports. 4453. https://researchrepository.wvu.edu/etd/4453 This Dissertation is protected by copyright and/or related rights. It has been brought to you by the The Research Repository @ WVU with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you must obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in WVU Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of The Research Repository @ WVU. For more information, please contact [email protected]. Ergot alkaloid biosynthesis in Aspergillus fumigatus: Association with sporulation and clustered genes common among ergot fungi Christine M. Coyle Dissertation submitted to the Davis College of Agriculture, Forestry, and Consumer Sciences at West Virginia University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Genetics and Developmental Biology Daniel G. Panaccione, Ph.D., Chair Kenneth P. Blemings, Ph.D. Joseph B. -
Clinical and Laboratory Profile of Chronic Pulmonary Aspergillosis
Original article 109 Clinical and laboratory profile of chronic pulmonary aspergillosis: a retrospective study Ramakrishna Pai Jakribettua, Thomas Georgeb, Soniya Abrahamb, Farhan Fazalc, Shreevidya Kinilad, Manjeshwar Shrinath Baligab Introduction Chronic pulmonary aspergillosis (CPA) is a type differential leukocyte count, and erythrocyte sedimentation of semi-invasive aspergillosis seen mainly in rate. In all the four dead patients, the cause of death was immunocompetent individuals. These are slow, progressive, respiratory failure and all patients were previously treated for and not involved in angio-invasion compared with invasive pulmonary tuberculosis. pulmonary aspergillosis. The predisposing factors being Conclusion When a patient with pre-existing lung disease compromised lung parenchyma owing to chronic obstructive like chronic obstructive pulmonary disease or old tuberculosis pulmonary disease and previous pulmonary tuberculosis. As cavity presents with cough with expectoration, not many studies have been conducted in CPA with respect to breathlessness, and hemoptysis, CPA should be considered clinical and laboratory profile, the study was undertaken to as the first differential diagnosis. examine the profile in our population. Egypt J Bronchol 2019 13:109–113 Patients and methods This was a retrospective study. All © 2019 Egyptian Journal of Bronchology patients older than 18 years, who had evidence of pulmonary Egyptian Journal of Bronchology 2019 13:109–113 fungal infection on chest radiography or computed tomographic scan, from whom the Aspergillus sp. was Keywords: chronic pulmonary aspergillosis, immunocompetent, laboratory isolated from respiratory sample (broncho-alveolar wash, parameters bronchoscopic sample, etc.) and diagnosed with CPA from aDepartment of Microbiology, Father Muller Medical College Hospital, 2008 to 2016, were included in the study. -
Taxonomy and Evolution of Aspergillus, Penicillium and Talaromyces in the Omics Era – Past, Present and Future
Computational and Structural Biotechnology Journal 16 (2018) 197–210 Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/csbj Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – Past, present and future Chi-Ching Tsang a, James Y.M. Tang a, Susanna K.P. Lau a,b,c,d,e,⁎, Patrick C.Y. Woo a,b,c,d,e,⁎ a Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong b Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong c State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong d Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong e Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong article info abstract Article history: Aspergillus, Penicillium and Talaromyces are diverse, phenotypically polythetic genera encompassing species im- Received 25 October 2017 portant to the environment, economy, biotechnology and medicine, causing significant social impacts. Taxo- Received in revised form 12 March 2018 nomic studies on these fungi are essential since they could provide invaluable information on their Accepted 23 May 2018 evolutionary relationships and define criteria for species recognition. With the advancement of various biological, Available online 31 May 2018 biochemical and computational technologies, different approaches have been adopted for the taxonomy of Asper- gillus, Penicillium and Talaromyces; for example, from traditional morphotyping, phenotyping to chemotyping Keywords: Aspergillus (e.g. lipotyping, proteotypingand metabolotyping) and then mitogenotyping and/or phylotyping. Since different Penicillium taxonomic approaches focus on different sets of characters of the organisms, various classification and identifica- Talaromyces tion schemes would result. -
Emerging Health Concerns in the Era of Cannabis Legalization
Emerging Health Concerns in the Era of Cannabis Legalization Iyad N. Daher, MD, FACC, FASE, FSCCT Chief Science Officer, VRX Labs Cannabis legalization is advancing worldwide * complicated … * Legalization impact on population use and health hazards More first-time users More volume of consumption (more exposure) More matrices (smoke/vape/cookies/gummies/drinks) More access to vulnerable populations (young, elderly, cancer, immunocompromised, fertile females, pregnant) More potential for inappropriate/accidental use (young, driving, operating machinery) More apparent cannabis related medical problems (increased reporting) Cannabis population health impact is yet to be fully understood Limited US federal funding Restrictions on research even with private funds (stigma, loss of federal funding) Paucity of quality data (small numbers, case reports, no longitudinal studies, biases (reporting/publishing/authors/editors/reviewers) Post marketing studies NOT mandated at this time How do these concerns compare with alcohol? Alcohol like Cannabis specific first time users Increased cannabis related medical problems (psychiatric, Increased exposure bad experience, vulnerable populations contaminants) (young, pregnant) More matrices inappropriate/accidental use (smoke/vape/cookies/gummie (young, driving, operating s/drinks) machinery) vulnerable populations (elderly, More apparent cancer, immunocompromised, fertile or pregnant females): contaminants Comparison to alcohol is useful but has limitations Cannabis and derived THC/CBD have -
Characterization of Terrelysin, a Potential Biomarker for Aspergillus Terreus
Graduate Theses, Dissertations, and Problem Reports 2012 Characterization of terrelysin, a potential biomarker for Aspergillus terreus Ajay Padmaj Nayak West Virginia University Follow this and additional works at: https://researchrepository.wvu.edu/etd Recommended Citation Nayak, Ajay Padmaj, "Characterization of terrelysin, a potential biomarker for Aspergillus terreus" (2012). Graduate Theses, Dissertations, and Problem Reports. 3598. https://researchrepository.wvu.edu/etd/3598 This Dissertation is protected by copyright and/or related rights. It has been brought to you by the The Research Repository @ WVU with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you must obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in WVU Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of The Research Repository @ WVU. For more information, please contact [email protected]. Characterization of terrelysin, a potential biomarker for Aspergillus terreus Ajay Padmaj Nayak Dissertation submitted to the School of Medicine at West Virginia University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Immunology and Microbial Pathogenesis Donald H. Beezhold, -
Superficial Fungal Infection
Infeksi jamur superfisial (mikosis superfisialis) R. Wahyuningsih Dep. Parasitologi FK UKI 31 Maret 2020 Klasifikasi mikosis superfisialis berdasarkan penyebab • Dermatofitosis • kandidiasis superfisialis • Infeksi Malassezia/panu M. Raquel Vieira, ESCMID Dermatofitosis • Infeksi jaringan keratin (kulit, kuku & rambut) oleh jamur filamen gol. dermatofita • genus dermatofita – Tricophyton, – Microsporum – Epidermophyton, • ± 10 spesies menyebabkan dermatofitosis pada manusia Asian incidence of the most common mycoses identified All values are percentages In Asia, T. rubrum and T. mentagrophytes are the most commonly isolated pathogens, causing tinea pedis and unguium, as is the case in Europe. Havlickova et al, Mycoses Dermatophytosis di Indonesia • Geofilik: M . gypseum • Zoofilik: M. canis • Antropofilik: – T. rubrum – T. concentricum – E. floccosum Patologi & organ terinfeksi Kuku kulit rambut Trichophyton + + + Microsporum + + + Epidermophyton + + - http://www.njmoldinspection.com/mycoses/moldinfections.html Dermatophytoses...... • Gejala klinik tergantung pada: • Lokalisasi infeksi • Respons imun pejamu • Spesies jamur • Lesi: karakteristik (ring worm) tetapi dalam kondisi imuno supresi menjadi tidak khas perlu pemeriksaan laboratorium Dermatofita & dermatofitosis T. rubrum: biakan. kapang, pigmen merah, mikrokonidia lonjong, tetesan air mata/anggur, makrokonidia seperti pinsil/cerutu . antropofilik, . kelainan kronik mis. • tinea kruris, onikomiksosis De Berker, N Engl J Med 2009;360:2108-16 Dermatofita & dermatofitosis M. canis -
The Interaction Between Tribolium Castaneum and Mycotoxigenic Aspergillus flavus in Maize Flour
insects Article The Interaction between Tribolium castaneum and Mycotoxigenic Aspergillus flavus in Maize Flour Sónia Duarte 1,2 , Ana Magro 1,*, Joanna Tomás 1, Carolina Hilário 1, Paula Alvito 3,4, Ricardo Boavida Ferreira 1,2 and Maria Otília Carvalho 1,2 1 Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal; [email protected] (S.D.); [email protected] (J.T.); [email protected] (C.H.); [email protected] (R.B.F.); [email protected] (M.O.C.) 2 LEAF—Linking Landscape, Environment, Agriculture and Food, Tapada da Ajuda, 1349-017 Lisboa, Portugal 3 National Health Institute Dr. Ricardo Jorge (INSA), 1600-609 Lisboa, Portugal; [email protected] 4 Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal * Correspondence: [email protected] Simple Summary: It is important to hold cereals in storage conditions that exclude insect pests such as the red flour beetle and fungi, especially mycotoxin-producing ones (as a few strains of Aspergillus flavus). This work aims to investigate the interaction between these two organisms when thriving in maize flour. It was observed that when both organisms were together, the mycotoxins detected in maize flour were far higher than when the fungi were on their own, suggesting that the presence of insects may contribute positively to fungi development and mycotoxin production. The insects in Citation: Duarte, S.; Magro, A.; contact with the fungi were almost all dead at the end of the trials, suggesting a negative effect of the Tomás, J.; Hilário, C.; Alvito, P.; fungi growth on the insects. -
Fusarium Subglutinans a New Eumycetoma Agent
Medical Mycology Case Reports 2 (2013) 128–131 Contents lists available at SciVerse ScienceDirect Medical Mycology Case Reports journal homepage: www.elsevier.com/locate/mmcr Fusarium subglutinans: A new eumycetoma agent$ Pablo Campos-Macías a, Roberto Arenas-Guzmán b, Francisca Hernández-Hernández c,n a Laboratorio de Microbiología, Facultad de Medicina, Universidad de Guanajuato, León, Guanajuato 37320, México b Sección de Micología, Hospital General Dr. Manuel Gea González, México D.F. 14080, México c Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F. 04510, México article info abstract Article history: Eumycetoma is a chronic subcutaneous mycosis mainly caused by Madurella spp. Fusarium opportunistic Received 31 May 2013 infections in humans are often caused by Fusarium solani and Fusarium oxysporum. We report a case of Received in revised form eumycetoma by F. subglutinans, diagnosed by clinical aspect and culture, and confirmed by PCR 20 June 2013 sequencing. The patient was successfully treated with oral itraconazole. To our knowledge, this is the Accepted 26 June 2013 second report of human infection and the first case of mycetoma by Fusarium subglutinans. & 2013 The Authors. Published by Elsevier B.V on behalf of International Society for Human and Animal Keywords: Mycology All rights reserved. Eumycetoma Mycetoma Fusarium subglutinans Itraconazole 1. Introduction eye infections [7,8], and infections of immunosuppressed patients [9]. To our knowledge, there had been only 1 case of Fusarium Mycetoma is an infectious, inflammatory and chronic disease subglutinans infection documented in the literature, a hyalohypho- that affects the skin and subcutaneous tissue. Regardless of the mycosis case in a 72-year-old seemingly immunocompetent patient aetiologic agent (bacteria or fungi), the clinical disease is essen- [10].