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Situation Update ** NOT FOR GENERAL DISTRIBUTION ** H7N9 situation update FAO / EMPRES – Animal Health 15 October 2013, 1700 hours; Rome Overview Situation: Avian influenza A(H7N9) virus with pandemic potential Country: People’s Republic of China Number of human cases: 136 confirmed; 45 deaths Provinces/municipalities: Beijing and Shanghai; Anhui, Fujian, Guangdong, Hebei, Henan, Hunan, Jiangsu, Jiangxi, Shandong, Zhejiang and Taiwan Province of China; Findings in animals: H7N9 confirmed in chickens, ducks, pigeons and environmental samples: 54 positive samples mainly from live bird markets and vendors FAO actions: liaise with China and partners, monitor situation, explore and assess virus characteristics, conduct market chain analysis, risk assessment, surveillance guidance and communication. Situation update Animals Virologically positive samples confirmed by national authorities Province Duck Pigeon Chicken Environmental Total Shanghai 0 3 10 7 20 Jiangsu 0 2 11 0 13 Anhui 1 0 0 0 1 Henan 0 0 0 2 2 Shandong 0 0 0 3 3 Jiangxi 0 0 1 0 1 Guangdong 0 0 2 0 2 Zhejiang 2 0 8 0 10 Fujian 0 0 0 1 1 TOTAL 3 5 32 13 53 Virologically positive samples reported in peer-reviewed articles Province Duck Pigeon Chicken Environmental Total Zhejiang 0 0 0 61* 61 Shandong 0 8** 0 0 8 TOTAL 0 0 0 0 69 *Eurosurveillance: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20481 **Nature: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12515.html Humans . Zhejiang province: a 35-year-old man in Shaoxin County was diagnosed with H7N9 avian influenza and is in serious condition. This is the first human case reported since 10 August 2013. Diagnosis and virus characteristics . Study of H7N9 genetic diversity increases as more sequences become public. A recent study showed: i) H7N9 viruses exhibit diverse genotypes; ii) the first reassortment likely occurred in wild birds and second in domestic birds; and iii) more than one H9N2 virus was involved in the creation of H7N9. Despite its diversity, H7N9 can still be detected by the current, validated diagnostic reagents. New isolates have been submitted to GISAID and GenBank / OpenFlu database: Host GISAID GenBank / OpenFluDB Chicken 34 25 Duck 2 2 Environment 15 14 Human 57 35 Pigeon 5 3 Total 113 79 Page 1 of 2; FAO/EMPRES H7N9 update Disclaimer: Information provided herein is current as of the date of issue. 15 October 2013 FAO cannot guarantee accuracy of information from reported sources. ** NOT FOR GENERAL DISTRIBUTION ** . Initial experiments at SERPL show existing, inactivated vaccines and available seed strains can reduce virus shedding in vaccinated chickens. The homologous Chinese H7N9 virus is still the most effective at reducing shedding. FAO actions . FAO continues supporting a-risk countries with surveillance and preparedness for H7N9 incursion. FAO assistance funded by USAID has supported the collection and analysis of nearly 10 000 bird and environmental swabs in South and Southeast Asia. No samples have tested positive. USAID continues supporting FAO activities in surveillance and preparedness, including compensation. FAO is finalizing H7N9 surveillance and sampling schemes for South and Southeast Asia. FAO launched TCP projects for SAARC and ASEAN regions at a participatory workshop on 18-20 September 2013: http://www.fao.org/asiapacific/rap/home/news/detail/en/?news_uid=197054 . FAO organized a USAID technical and policy meeting in Rome, 12–13 September 2013. On 26 April FAO called for USD 35 million to support the new global framework on H7N9. On 26 April FAO made public its new web portal on H7N9: www.fao.org/h7n9 . FAO guidance is online: risk management, surveillance, risk assessment and lab protocols Important links . Ministry of Agriculture of the People’s Republic of China: www.moa.gov.cn/zwllm/yjgl/yqfb/ . Ministry of Forestry of the People’s Republic of China: www.forestry.gov.cn . FAO Frequently Asked Questions: http://www.fao.org/ag/againfo/programmes/en/empres/H7N9/Faq.html . FAO/EMPRES Animal Health News: www.fao.org/ag/againfo/programmes/en/empres/news.htm . OFFLU updated laboratory protocols: http://www.offlu.net/index.php?id=267 . WHO disease outbreak news: www.who.int/csr/don/archive/year/2013/en/index.html . Latest WHO review: http://ow.ly/nQDA7 . WHO recommendations on biorisk: http://ow.ly/nQDOn . World Animal Health Information Database: www.oie.int/wahis_2/public/wahid.php . Centers for Disease Control and Prevention: http://www.cdc.gov/flu/avianflu/h7n9-virus.htm . Global Initiative on Sharing Avian Influenza Data: www.gisaid.org . NCBI Influenza Virus Resource data base: http://www.ncbi.nlm.nih.gov/genomes/FLU/ Map Human cases and positive findings in bird and environment Page 2 of 2; FAO/EMPRES H7N9 update Disclaimer: Information provided herein is current as of the date of issue. 15 October 2013 FAO cannot guarantee accuracy of information from reported sources. ** NOT FOR GENERAL DISTRIBUTION ** H7N9 situation update FAO / EMPRES – Animal Health 17 October 2013, 1700 hours; Rome Overview Situation: Avian influenza A(H7N9) virus with pandemic potential Country: People’s Republic of China Number of human cases: 136 confirmed; 45 deaths Provinces/municipalities: Beijing and Shanghai; Anhui, Fujian, Guangdong, Hebei, Henan, Hunan, Jiangsu, Jiangxi, Shandong, Zhejiang and Taiwan Province of China; Findings in animals: H7N9 confirmed in chickens, ducks, pigeons and environmental samples: 54 positive samples mainly from live bird markets and vendors FAO actions: liaise with China and partners, monitor situation, explore and assess virus characteristics, conduct market chain analysis, risk assessment, surveillance guidance and communication. Situation update Animals Virologically positive samples confirmed by national authorities Province Duck Pigeon Chicken Environmental Total Shanghai 0 3 10 7 20 Jiangsu 0 2 11 0 13 Anhui 1 0 0 0 1 Henan 0 0 0 2 2 Shandong 0 0 0 3 3 Jiangxi 0 0 1 0 1 Guangdong 0 0 2 0 2 Zhejiang 2 0 8 0 10 Fujian 0 0 0 1 1 TOTAL 3 5 32 13 53 Virologically positive samples reported in peer-reviewed articles Province Duck Pigeon Chicken Environmental Total Zhejiang 0 0 0 61* 61 Shandong 0 8** 0 0 8 TOTAL 0 0 0 0 69 *Eurosurveillance: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20481 **Nature: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12515.html Humans . First human case since 10 August 2013: A 35-year-old man in Shaoxin County, Zhejiang Province diagnosed with H7N9 is in serious condition. Outbreak investigation is ongoing. Diagnosis and virus characteristics . Study of H7N9 genetic diversity increases as more sequences become public. A recent study showed: i) H7N9 viruses exhibit diverse genotypes; ii) the first reassortment likely occurred in wild birds and second in domestic birds; and iii) more than one H9N2 virus was involved in the creation of H7N9. Despite its diversity, H7N9 can still be detected by the current, validated diagnostic tests. New isolates have been submitted to GISAID and GenBank / OpenFlu database: Host GISAID GenBank / OpenFluDB Chicken 34 25 Duck 2 2 Environment 15 14 Human 57 35 Pigeon 5 3 Total 113 79 Page 1 of 2; FAO/EMPRES H7N9 update Disclaimer: Information provided herein is current as of the date of issue. 17 October 2013 FAO cannot guarantee accuracy of information from reported sources. ** NOT FOR GENERAL DISTRIBUTION ** . Initial experiments at SERPL show existing, inactivated vaccines and available seed strains can reduce virus shedding in vaccinated chickens. The homologous Chinese H7N9 virus is still the most effective at reducing shedding. FAO actions . FAO continues supporting a-risk countries with surveillance and preparedness for H7N9 incursion. FAO assistance funded by USAID has supported the collection and analysis of nearly 10 000 bird and environmental swabs in South and Southeast Asia. No samples have tested positive. USAID continues supporting FAO activities in surveillance and preparedness, including compensation. FAO is finalizing H7N9 surveillance and sampling schemes for South and Southeast Asia. FAO launched TCP projects for SAARC and ASEAN regions at a participatory workshop on 18-20 September 2013: http://www.fao.org/asiapacific/rap/home/news/detail/en/?news_uid=197054 . FAO organized a USAID technical and policy meeting in Rome, 12–13 September 2013. On 26 April FAO called for USD 35 million to support the new global framework on H7N9. On 26 April FAO made public its new web portal on H7N9: www.fao.org/h7n9 . FAO guidance is online: risk management, surveillance, risk assessment and lab protocols Important links . Ministry of Agriculture of the People’s Republic of China: www.moa.gov.cn/zwllm/yjgl/yqfb/ . Ministry of Forestry of the People’s Republic of China: www.forestry.gov.cn . FAO Frequently Asked Questions: http://www.fao.org/ag/againfo/programmes/en/empres/H7N9/Faq.html . FAO/EMPRES Animal Health News: www.fao.org/ag/againfo/programmes/en/empres/news.htm . OFFLU updated laboratory protocols: http://www.offlu.net/index.php?id=267 . WHO disease outbreak news: www.who.int/csr/don/archive/year/2013/en/index.html . Latest WHO review: http://ow.ly/nQDA7 . WHO recommendations on biorisk: http://ow.ly/nQDOn . World Animal Health Information Database: www.oie.int/wahis_2/public/wahid.php . Centers for Disease Control and Prevention: http://www.cdc.gov/flu/avianflu/h7n9-virus.htm . Global Initiative on Sharing Avian Influenza Data: www.gisaid.org . NCBI Influenza Virus Resource data base: http://www.ncbi.nlm.nih.gov/genomes/FLU/ Map Human cases and positive
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