Infectious Diseases of Haiti
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Five Facts About Giardia Lamblia
PEARLS Five facts about Giardia lamblia Lenka Cernikova, Carmen FasoID, Adrian B. HehlID* Laboratory of Molecular Parasitology, Institute of Parasitology, University of Zurich (ZH), Zurich, Switzerland * [email protected] Fact 1: Infection with Giardia lamblia is one of the most common causes of waterborne nonbacterial and nonviral diarrheal disease G. lamblia (syn. intestinalis, duodenalis) is a zoonotic enteroparasite. It proliferates in an extra- cellular and noninvasive fashion in the small intestine of vertebrate hosts, causing the diarrheal disease known as giardiasis. Virtually all mammals can be infected with G. lamblia, and epide- miological data point to giardiasis as a zoonosis [1]. Infections in humans may be asymptom- atic or associated with diarrhea, malabsorption, bloating, abdominal pain, fatigue, and weight loss. Based on the latest figures provided by WHO, G. lamblia is the third most common agent of diarrheal disease worldwide with over 300 million reported cases per annum, preceded only a1111111111 by rotavirus and Cryptosporidium parvum and hominis in the most vulnerable target group of a1111111111 a1111111111 children under five years of age [2]. The prevalence of giardiasis in humans ranges from 2%± a1111111111 3% in industrialized countries, up to 30% in low-income and developing countries [3]. Giardi- a1111111111 asis was formerly included in the WHO neglected diseases initiative and is directly associated with poverty and poor quality of drinking water [4]. Acute infection develops over a period of three weeks, peaking at eight days post infection. Generally, healthy hosts clear the infection within 2±3 weeks, whereas the occasional chronically infected host shows signs of villus and crypt atrophy, enterocyte apoptosis, and ultimately severe disruption of epithelial barrier func- OPEN ACCESS tion [5]. -
Intestinal Protothecosis in a Young Bengal Cat
Open Journal of Veterinary Medicine, 2021, 11, 157-164 https://www.scirp.org/journal/ojvm ISSN Online: 2165-3364 ISSN Print: 2165-3356 Intestinal Protothecosis in a Young Bengal Cat Sara Manfredini1, Luca Formaggini1, Michele Marino2, Luigi Venco1* 1Clinica Veterinaria Lago Maggiore, Dormelletto (NO), Italy 2Laboratorio Analisi Veterinarie La Vallonea, Passirana di Rho (MI), Italy How to cite this paper: Manfredini, S., Abstract Formaggini, L., Marino, M. and Venco, L. (2021) Intestinal Protothecosis in a Young Background: Intestinal protothecosis is an uncommon and insidious mycotic Bengal Cat. Open Journal of Veterinary disease. Only one human case and a few rare cases in dogs have been reported. Medicine, 11, 157-164. To the authors’ knowledge, intestinal protothecosis has never been reported https://doi.org/10.4236/ojvm.2021.115011 in cats. Case description: This paper describes a case of intestinal prototheco- Received: March 19, 2021 sis in a nine-month-old male, Bengal cat. The cat presented because of onset Accepted: May 15, 2021 of haemorrhagic diarrhoea. Investigations allowed diagnosis of intestinal pro- Published: May 18, 2021 tothecosis, confirmed by PCR test on faeces. Treatment with itraconazole did Copyright © 2021 by author(s) and not improve the clinical signs. Treatment with nystatin was prescribed and Scientific Research Publishing Inc. caused improvement in the clinical signs and decreased number of pathogens This work is licensed under the Creative seen on faecal cytology. PCR on faecal samples was negative two months after Commons Attribution International License (CC BY 4.0). treatment, with complete resolution of symptoms. Conclusion: Infection with http://creativecommons.org/licenses/by/4.0/ Prototheca should be part of the list of differential diagnoses for diarrhoea in Open Access cats. -
Granuloma De Las Piscinas Carcinoma Basocelular Localmente Avanzado
Penfigoide gestacional pustuloso Granuloma facial de localización atípica Programa de Educación Médica Continua Variantes de Archivos Argentinos de Dermatología clínicas inusuales de Año 2019, volumen 5, número 4 sarcoidosis Octubre, Noviembre y Diciembre 2019. cutánea Precio: $200 Carcinoma basocelular localmente avanzado tratado con Vismodegib Granuloma de las piscinas www.archivosdermato.org.ar [email protected] Educando Nos Programa de Educación Médica Continua de Archivos Argentinos de Dermatología Año 2019, volumen 5, número 4 Sumario Octubre, Noviembre y Diciembre 2019 Editorial Acrodermatitis enteropática 3 Glorio Roberto 36 Ruiz Díaz María, Kuen Bernardita, Caggia Antonella, Díaz Ysabel, Lozinsky Liliana 4 Reglamento de publicaciones Jornadas de Educación 40 Médica Continua Granuloma facial de 6 localización atípica Carcinoma basocelular Digilio Marianela, Manzano Roxana, Bendjuia Gabriela, 42 localmente avanzado tratado Schroh Roberto, Feinsilber Daniel con Vismodegib Van Caester Leandro Rodolfo, Alfaro María Florencia, Consigli Javier, De La Colina Marcelo, Manrique Valeria, Variantes clínicas inusuales de Pereyra Susana Beatriz 10 sarcoidosis cutánea Espósito Daniela, Márquez, Juan Manuel, López Di Noto Ada Laura, Marcucci Carolina, Sánchez Graciela, Merola Gladys Seguimiento en pacientes 46 sensibilizados a Queratosis folicular invertida de metilisotiazolinona 18 localización infrecuente Russo Juan Pedro, Palazzolo Juan Francisco, Adorni Romina, Consigli Carlos Landau Débora, Caruso Territoriale Antonella, Valente -
A Multifaceted Approach to Combating Leishmaniasis, a Neglected Tropical Disease
OLD TARGETS AND NEW BEGINNINGS: A MULTIFACETED APPROACH TO COMBATING LEISHMANIASIS, A NEGLECTED TROPICAL DISEASE DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy from the Graduate School of The Ohio State University By Adam Joseph Yakovich, B.S. ***** The Ohio State University 2007 Dissertation Committee: Karl A Werbovetz, Ph.D., Advisor Approved by Pui-Kai Li, Ph.D. Werner Tjarks, Ph.D. ___________________ Ching-Shih Chen, Ph.D Advisor Graduate Program In Pharmacy ABSTRACT Leishmaniasis, a broad spectrum of disease which is caused by the protozoan parasite Leishmania , currently affects 12 million people in 88 countries worldwide. There are over 2 million of new cases of leishmaniasis occurring annually. Clinical manifestations of leishmaniasis range from potentially disfiguring cutaneous leishmaniasis to the most severe manifestation, visceral leishmaniasis, which attacks the reticuloendothelial system and has a fatality rate near 100% if left untreated. All currently available therapies all suffer from drawbacks including expense, route of administration and developing resistance. In the laboratory of Dr. Karl Werbovetz our primary goal is the identification and development of an inexpensive, orally available antileishmanial chemotherapeutic agent. Previous efforts in the lab have identified a series of dinitroaniline compounds which have promising in vitro activity in inhibiting the growth of Leishmania parasites. It has since been discovered that these compounds exert their antileishmanial effects by binding to tubulin and inhibiting polymerization. Remarkably, although mammalian and Leishmania tubulins are ~84 % identical, the dinitroaniline compounds show no effect on mammalian tubulin at concentrations greater than 10-fold the IC 50 value determined for inhibiting Leishmania tubulin ii polymerization. -
Giardiasis Importance Giardiasis, a Gastrointestinal Disease Characterized by Acute Or Chronic Diarrhea, Is Caused by Protozoan Parasites in the Genus Giardia
Giardiasis Importance Giardiasis, a gastrointestinal disease characterized by acute or chronic diarrhea, is caused by protozoan parasites in the genus Giardia. Giardia duodenalis is the major Giardia Enteritis, species found in mammals, and the only species known to cause illness in humans. This Lambliasis, organism is carried in the intestinal tract of many animals and people, with clinical signs Beaver Fever developing in some individuals, but many others remaining asymptomatic. In addition to diarrhea, the presence of G. duodenalis can result in malabsorption; some studies have implicated this organism in decreased growth in some infected children and Last Updated: December 2012 possibly decreased productivity in young livestock. Outbreaks are occasionally reported in people, as the result of mass exposure to contaminated water or food, or direct contact with infected individuals (e.g., in child care centers). People are considered to be the most important reservoir hosts for human giardiasis. The predominant genetic types of G. duodenalis usually differ in humans and domesticated animals (livestock and pets), and zoonotic transmission is currently thought to be of minor significance in causing human illness. Nevertheless, there is evidence that certain isolates may sometimes be shared, and some genetic types of G. duodenalis (assemblages A and B) should be considered potentially zoonotic. Etiology The protozoan genus Giardia (Family Giardiidae, order Giardiida) contains at least six species that infect animals and/or humans. In most mammals, giardiasis is caused by Giardia duodenalis, which is also called G. intestinalis. Both names are in current use, although the validity of the name G. intestinalis depends on the interpretation of the International Code of Zoological Nomenclature. -
Diagnostic Code Descriptions (ICD9)
INFECTIONS AND PARASITIC DISEASES INTESTINAL AND INFECTIOUS DISEASES (001 – 009.3) 001 CHOLERA 001.0 DUE TO VIBRIO CHOLERAE 001.1 DUE TO VIBRIO CHOLERAE EL TOR 001.9 UNSPECIFIED 002 TYPHOID AND PARATYPHOID FEVERS 002.0 TYPHOID FEVER 002.1 PARATYPHOID FEVER 'A' 002.2 PARATYPHOID FEVER 'B' 002.3 PARATYPHOID FEVER 'C' 002.9 PARATYPHOID FEVER, UNSPECIFIED 003 OTHER SALMONELLA INFECTIONS 003.0 SALMONELLA GASTROENTERITIS 003.1 SALMONELLA SEPTICAEMIA 003.2 LOCALIZED SALMONELLA INFECTIONS 003.8 OTHER 003.9 UNSPECIFIED 004 SHIGELLOSIS 004.0 SHIGELLA DYSENTERIAE 004.1 SHIGELLA FLEXNERI 004.2 SHIGELLA BOYDII 004.3 SHIGELLA SONNEI 004.8 OTHER 004.9 UNSPECIFIED 005 OTHER FOOD POISONING (BACTERIAL) 005.0 STAPHYLOCOCCAL FOOD POISONING 005.1 BOTULISM 005.2 FOOD POISONING DUE TO CLOSTRIDIUM PERFRINGENS (CL.WELCHII) 005.3 FOOD POISONING DUE TO OTHER CLOSTRIDIA 005.4 FOOD POISONING DUE TO VIBRIO PARAHAEMOLYTICUS 005.8 OTHER BACTERIAL FOOD POISONING 005.9 FOOD POISONING, UNSPECIFIED 006 AMOEBIASIS 006.0 ACUTE AMOEBIC DYSENTERY WITHOUT MENTION OF ABSCESS 006.1 CHRONIC INTESTINAL AMOEBIASIS WITHOUT MENTION OF ABSCESS 006.2 AMOEBIC NONDYSENTERIC COLITIS 006.3 AMOEBIC LIVER ABSCESS 006.4 AMOEBIC LUNG ABSCESS 006.5 AMOEBIC BRAIN ABSCESS 006.6 AMOEBIC SKIN ULCERATION 006.8 AMOEBIC INFECTION OF OTHER SITES 006.9 AMOEBIASIS, UNSPECIFIED 007 OTHER PROTOZOAL INTESTINAL DISEASES 007.0 BALANTIDIASIS 007.1 GIARDIASIS 007.2 COCCIDIOSIS 007.3 INTESTINAL TRICHOMONIASIS 007.8 OTHER PROTOZOAL INTESTINAL DISEASES 007.9 UNSPECIFIED 008 INTESTINAL INFECTIONS DUE TO OTHER ORGANISMS -
WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA). -
Kikuchi Disease with Generalized Lymph Node, Spleen And
Case Report Mol Imaging Radionucl Ther 2016;25:102-106 DOI:10.4274/mirt.25338 Kikuchi Disease with Generalized Lymph Node, Spleen and Subcutaneous Involvement Detected by Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Flor-18-Florodeoksiglukoz Pozitron Emisyon Tomografisi/Bilgisayarlı Tomografi ile Saptanan Yaygın Lenf Nodu, Dalak ve Deri Altı Tutulumu Olan Kikuchi Hastalığı Alshaima Alshammari1, Evangelia Skoura2, Nafisa Kazem1, Rasha Ashkanani1 1Mubarak Al Kabeer Hospital, Clinic of Nuclear Medicine, Jabriya, Kuwait 2University College London Hospital, Clinic of Nuclear Medicine, London, United Kingdom Abstract Kikuchi-Fujimoto disease, known as Kikuchi disease, is a rare benign and self-limiting disorder that typically affects the regional cervical lymph nodes. Generalized lymphadenopathy and extranodal involvement are rare. We report a rare case of a 19-year- old female with a history of persistent fever, nausea, and debilitating malaise. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed multiple hypermetabolic generalized lymph nodes in the cervical, mediastinum, axillary, abdomen and pelvic regions with diffuse spleen, diffuse thyroid gland, and focal parotid involvement, bilaterally. In addition, subcutaneous lesions were noted in the left upper paraspinal and occipital regions. An excisional lymph node biopsy guided by 18F-FDG PET/CT revealed the patient’s diagnosis as Kikuchi syndrome. Keywords: Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, fluorine-18-fluorodeoxyglucose Öz Kikuchi hastalığı olarak bilinen Kikuchi-Fujimoto hastalığı, genellikle bölgesel servikal lenf düğümlerini etkileyen, nadir görülen benign ve kendini sınırlayıcı bir hastalıktır. Yaygın lenfadenopati ve ekstranodal tutulum nadirdir. Bu yazıda sürekli ateş, bulantı ve halsizlik şikayetleri olan 19 yaşında bir kadın hasta sunulmaktadır. -
Laboratory Manual for Diagnosis of Sexually Transmitted And
Department of AIDS Control LaborLaboraattororyy ManualManual fforor DiagnosisDiagnosis ofof SeSexxuallyually TTrransmitansmittteded andand RRepreproductivoductivee TTrractact InInffectionsections FOREWORD Sexually Transmitted Infections (STIs) and Reproductive Tract Infections (RTIs) are diseases of major global concern. About 6% of Indian population is reported to be having STIs. In addition to having high levels of morbidity, they also facilitate transmission of HIV infection. Thus control of STIs goes hand in hand with control of HIV/AIDS. Countrywide strengthening of laboratories by helping them to adopt uniform standardized protocols is very important not only for case detection and treatment, but also to have reliable epidemiological information which will help in evaluation and monitoring of control efforts. It is also essential to have good referral services between primary level of health facilities and higher levels. This manual aims to bring in standard testing practices among laboratories that serve health facilities involved in managing STIs and RTIs. While generic procedures such as staining, microscopy and culture have been dealt with in detail, procedures that employ specific manufacturer defined kits have been left to the laboratories to follow the respective protocols. An introduction to quality system essentials and quality control principles has also been included in the manual to sensitize the readers on the importance of quality assurance and quality management system, which is very much the need of the hour. Manual of Operating Procedures for Diagnosis of STIs/RTIs i PREFACE Sexually Transmitted Infections (STIs) are the most common infectious diseases worldwide, with over 350 million new cases occurring each year, and have far-reaching health, social, and economic consequences. -
Blastocystis Hominis Transmission by Non-Potable Water: a Case Report In
NEW MICROBIOLOGICA, 41, 2, 173-177, 2018, ISN 1121-7138 CASE REPORT Blastocystis hominis transmission by non-potable water: a case report in Italy Maria Cristina Angelici, Chiara Nardis, Riccardo Scarpelli, Paola Ade Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy SUMMARY In the reported case, a 41-year-old Italian man came to the clinician’s observation reporting cramps, bloat- ing and watery diarrhoea a few days after drinking water indicated as unpotable from a fountain in a farm area. The medical suspicion was directed at both gluten intolerance and enteric infection, eventually of waterborne origin. Gluten intolerance was investigated by intestinal biopsy and excluded, while stool analyses ruled out infective bacteriological or viral agents and parasites. Subsequently, a persistent eo- sinophilia was revealed and a parasitological analysis was again suggested, planning for a more sensitive molecular method. Therefore, a multiplex-PCR of enteric protozoa species DNA was performed on an intestinal biopsy and faecal samples revealing only Blastocystis hominis protozoa, subsequently typed as subtype 1 by RFLP-PCR method. B. hominis is an anaerobic protozoa found in the human and animal intestinal tract, recently associated with a pathogenic role characterized by chronic development. Since blastocystosis has been demonstrated as a waterborne infection, a sample of water matrix was analysed, revealing the B. hominis subtype 1 DNA inside. A probable water transmission of Blastocystis infection has been demonstrated in this case report. Only a probiotic treatment based on Saccharomyces boulardii was administered to the patient and this apparently resolved the infection. In summary, the case described here is a chronic blastocystosis of possible waterborne origin, controlled by assuming a yeast treatment. -
Focus: Blood Cancer
JAN-MAR 17 www.singhealth.com.sg A SingHealth Newsletter for Medical Practitioners MCI (P) 027/11/2016 FOCUS: BLOOD CANCER Haematologic Emergencies An Overview of in the General Practice Myeloproliferative Neoplasms When to Suspect Approach to an Adult with Myeloma in Primary Care Lymphadenopathy in Primary Care SingHealth Duke-NUS Academic Medical Centre • Singapore General Hospital • KK Women’s and Children’s Hospital • Sengkang Health • National Cancer Centre Singapore • National Dental Centre of Singapore • National Heart Centre Singapore • National Neuroscience Institute • Singapore National Eye Centre • SingHealth Polyclinics • Bright Vision Hospital Medical Appointments: 6321 4402 (SGH) Focus: Update Blood Cancer 6436 8288 (NCCS) Haematologic Emergencies in the General Practice Adj Assoc Prof Wong Gee Chuan, Senior Consultant, Department of Haematology, Singapore General Hospital; SingHealth Duke-NUS Blood Cancer Centre Patients with malignant haematological diseases may present with dramatic and life-threaten- ing complications. General physicians must be able to recognise these conditions as prompt treatment can be life-saving. Hyperleukocytosis and leukostasis and febrile neutropaenia in patients with haematologic malignancies are two such conditions highlighted in this article. mental state and unsteadiness in gait. patient presents with a high white cell HYPERLEUKOCYTOSIS AND There is also increased risk of intracra- count and symptoms suggestive of tis- LEUKOSTASIS IN HAEMATOLOGIC nial haemorrhage. sue hypoxia. MALIGNANCIES Besides affecting the central nervous Hyperleukocytosis has been variably system, eyes and lungs, other manifes- Leukostasis constitutes a medi- defined as a total white cell count tations include myocardial ischaemia, cal emergency. Prompt treatment (WBC) of 50 x 109/L or 100 x 109/L. Leu- limb ischaemia or bowel infarction. -
Hymenolepis Nana Is a Ubiquitous Parasite, Found Throughout Many Developing and Developed Countries
Characterisation of Community-Derived Hymenolepis Infections in Australia Marion G. Macnish BSc. (Medical Science) Hons Division of Veterinary and Biomedical Sciences Murdoch University Western Australia This thesis is presented for the degree of Doctor of Philosophy of Murdoch University 2001 I declare that this thesis is my own account of my research and contains as its main work which has not been submitted for a degree at any other educational institution. ………………………………………………. (Marion G. Macnish) Characterisation of Community-Derived Hymenolepis Infections in Australia ii Abstract Hymenolepis nana is a ubiquitous parasite, found throughout many developing and developed countries. Globally, the prevalence of H. nana is alarmingly high, with estimates of up to 75 million people infected. In Australia, the rates of infection have increased substantially in the last decade, from less than 20% in the early 1990’s to 55 - 60% in these same communities today. Our knowledge of the epidemiology of infection of H. nana is hampered by the confusion surrounding the host specificity and taxonomy of this parasite. The suggestion of the existence of two separate species, Hymenolepis nana von Siebold 1852 and Hymenolepis fraterna Stiles 1906, was first proposed at the beginning of the 20th century. Despite ongoing discussions in the subsequent years it remained unclear, some 90 years later, whether there were two distinct species, that are highly host specific, or whether they were simply the same species present in both rodent and human hosts. The ongoing controversy surrounding the taxonomy of H. nana has not yet been resolved and remains a point of difference between the taxonomic and medical literature.