Neuroinflammation and Alzheimer’s disease

Get to the root cause of neurodegeneration with these tools Amyloid beta

Anti-beta Amyloid Detect beta amyloid 1-42 peptides with ab201060 1-42 antibody this recombinant monoclonal antibody. Aβ clearance Active Release of proinflammatory mediators Recombinant Explore the role of amyloid precursor protein microglia IL-1β, IL-6, TNFα, IFNγ, MIP-1α, MIP-1β, RANTES, MCP1, M-CSF Anti-Amyloid Precursor ab32136 with this recombinant monoclonal antibody. Protein antibody

TREM2 To find out more about amyloid beta research tools, visit www.abcam.com/neuroscience/alzheimers-disease Migrating Tau

microglia Anti-Tau (phospho Quickly detect phospho S396 tau with this Synapse ab109390 Aβ plaque S396) antibody versatile antibody. Available in 10 μl trial format. Reactive loss astrocytes Anti-Tau Alzheimer’s Neuronal Disease antibody Study Alzheimer’s disease specific tau pathology ab246808 [GT-38] - with our GT-38 antibody. GFAP damage Conformation-Specific and death Clq C3 To learn about other products to study tau, visit www.abcam. com/neuroscience/beta-amyloid-and-tau-in-alzheimers-disease Glia Tau neurofibrillary Distinguish microglia from macrophages and tangles (NFTs) CR3 Anti-TMEM119 antibody other immune cells with this stable and specific ab209064 MCP-1 microglial marker. Effortlessly label astrocytes with this astrocyte gradient Anti-GFAP antibody ab33922 Amyloidogenic marker. APP processing Caspase 3 For more help choosing neural markers, visit www.abcam.com/glia Aβ GSK3β Proinflammatory mediators Caspase 7 Detect proinflammatory mediators, such as Mouse TNF alpha ELISA TNF-alpha, in just 90 minutes with a SimpleStep ab208348 Kit ® β-secretase Microglial ELISA kit. complement To discover the range of SimpleStep ELISA kits, visit www.abcam. Tau paired helical com/simplestep-elisa γ-secretase P activation filaments (PHFs) Human and mouse key Profile multiple cytokines at once with a multiplex ab243549 Cdk5 Cdk5 cytokine panels panel or design your own. ab235656

To learn more about Fireplex immunoassays, visit www.abcam. p35 p25 com/fireplex-immunoassays

Calpain Ca2+ + AICD CaŒ + + CaŒ Blood brain C99 CaŒ P P Oligomeric + + CaŒ Axon terminal barrier APP Tau CaŒ Proteosomal P P degradation P P P Glutamate P P Soluble Aβ P P P P NMDA P P P oligomer Ubiquitin P P receptor P P P P P P P P AMPA P P P CCR2 P P P receptor P gradient P P CaŒ+ Autophagy P P P P P CaŒ+ Membrane Tau mislocalization damage P + to dendritic spine PSD95 CaŒ FYN CaŒ+ Infiltration of monocytes Tau CaŒ+ ROS and macrophages hyperphosphorylation CaŒ+ Tau on FYN P CaŒ+ microtubules P P Apoptosis FYN P Tau P P P P Ca2+ overload P

Dendritic spine Axon

To find out more, please visitwww. abcam.com/neuroinflammation

Copyright © 2017 Abcam, All rights reserved. Poster compiled with help from Dr John-Ioannis Sotiropoulos, ICVS.