Web Edition: extra content on pages 27-30

The National Cancer Institute at Frederick

Do you know anyone here? Story on page 12.

From the Director’s Office JANUARY 2003

Welcome to issue #1 of The Poster, only Federally-funded Research and N HIS SSUE NCI-Frederick’s new quarterly Development Center (FFRDC), with a I T I newsletter. The NCI-Frederick staff combined annual budget of over $300 have gone to great lengths to provide million. Comings and Goings 3 you with a very interesting and The NCI-Frederick is not only informative product. This is your a very important part of the NIH, Charles River Laboratories 4 newsletter and we look forward to it is also an important part of the your comments regarding The Poster. Frederick community. With more than Data Management Services 4 As we began to gather information 2,700 employees, the NCI-Frederick about the NCI- generates more SAIC-Frederick, Inc. 5 Frederick and than $100 its colorful million per year Wilson Information Services history for this for the local Corporation 6 issue of The economy. But the Poster, one NCI-Frederick Science Today 7 thing became also contributes very clear to to our local Platinum Publications 8 me–this is a community great place to in many other Environment, Health, and Safety Program 11 work! ways, including What makes volunteer Did You Know? 12 the NCI- activities such as Frederick such a great place for us to the Elementary Outreach and Werner Community Outreach 14 work? For more than 30 years, NCI- Kirsten Student Intern programs. Frederick has been an important part In addition, the NCI-Frederick staff Frederick Employee Diversity of the Frederick community and has make substantial contributions to the Team 16 played a critical role in America’s war Combined Federal Campaign and on cancer. Since 1970 when President other local charities. Further, many Facilities Management, Nixon created the NCI-Frederick (then individuals serve as faculty at local Engineering, and Planning 18 called the Frederick Cancer Research colleges and universities. and Development Center), this facility It’s easy to see why the NCI- Poster-Script 19 has contributed significantly to our Frederick is considered by scientists nation’s efforts to fight cancer and throughout the world to be one of the Administrative Resource AIDS. most important biomedical research Center 20 The importance of NCI-Frederick to facilities anywhere. Such noted the NIH is best reflected in the more scientists as Albert Sabin (Presidential Job Vacancies 22 than 200% increase in our budget and Medal of Freedom), Carlton near doubling of our staff since 1987. Gajdusek (Nobel Prize), and George NIH Human Resources 24 You may not know it, but the NCI- VandeWoude (National Academy Frederick is the largest biomedical of Sciences) have all worked at the research organization in Frederick Facility. Importantly, the scientific County and is also the US Department staff here at the NCI-Frederick of Health and Human Services’ continues to uphold this tradition of continued on page 2 From the Director’s Office continued from page 1 excellence in research by publishing Yes, I know many of you feel, as more than 750 papers per year in the I do, that the NCI-Frederick is a world’s foremost biomedical journals. wonderful place to work. The addition However, I think it is fair to say that of our new newsletter, The Poster, will what really makes the NCI-Frederick make it even better. What a great way a great place to work is the dedication to start the New Year, knowing that and quality of all the people who each of you is contributing in a special work here–the technicians and way towards a cure for cancer and fellows; the secretaries and clerks; the AIDS. engineers, plumbers and electricians; the custodial staff; and all the other Happy New Year and keep up the talented people who work diligently in great work. I’m proud of you all. ö support of the NCI-Frederick and its mission. NCI-Frederick employees–you should all take pride in your excellent Craig Reynolds, work. I hope that you understand Director of how appreciative the nation is of your the Office of Scientific Operations efforts to help in our fight against cancer and AIDS.

Happy New Year!

Following is a list of new year’s German: Glückliches neues Jahr Norwegian: Glad nytt år greetings in various languages. Pick out your favorite, practice saying Greek: Eftecheezmaenos o Polish: Szczesliwego Nowego it, and wish everyone you know a Kaenooryos hronos Roku happy new year–even in April! Hebrew: L’Shannah Tovah Portuguese: Feliz Ano Novo Arabic: Kul ‘aam u antum Tikatevu salimoun Russian: Novim Godom Hindi: Naya Salmubarak Chinese: Chu Shen Tan or Gong Swahili: Habari gani Xi Facai Irish (Gaelic): Bliain nua fe mhaise dhuit Serbo-Croatian: Scecna nova Czechoslavakian: Scastny Novy godina Rok Italian: Buon Capo d’anno Spanish: Feliz Año Nuevo Dutch: Gullukkig Niuw Jaar Khmer: Sua Sdei tfnam tmei Turkish: Yeni Yiliniz Kutlu Olsun Finnish: Onnellista Uutta Vuotta Laotian: Sabai dee pee mai Vietnamese: Cung-Chuc Tan- French: Bonne Année Malaysian: Selamat hari raya Xuan

The NCI-Frederick Poster 2 January 2003 Comings and Goings

NCI-Frederick welcomes the following employees who began work here in October through December:

Wayne Appenzellar, Nole Baichoo, Jason Bangh, Aubrey Banig, Himadri Bhattachanga, Erick Blanco, Elizabeth Buck, Gerald Burge, Sandra Burkett, James Burnett, John Cardellina II, Caroline Chang, Amanda Debes, Angela De Palatis, Andrew Eckert, Erin Fleming, John Freymann, Kathleen Fulmer, Charles Galloway, Denise Gouker, Beth Henndon, Michaela Hernandez, Linda Ingram, Tretyakova Irina, Susan Jessee, Ronald Keilholtz, Edward Kitler, Anthony Lee, Zhi Yu Li, James Lipchock, Beverly Maccarthy, Krajewska Magdelela, Gordon Main, Yafen McLaren, Willoughby Moxley, Beena Neelam, Danielle Needle, Il Ung Oh, Jessica Oliver, Lorene Pregenzer, Phillip Ramsey, Shashikala Ratnayake, Chris Rowe, Marcus Smith, Nicole Smith, Robin Smith, Masoweh Soheilian, Julia Solarczyk, Amber Steele, Sarah Stocks, Agnieszka Szyk, Sasha Tetu, Yanyu Wang, Jessica Zalek, and Heming Zhu. ö

Kathleen Fulmer Caroline Chang

Marcus Smith Beth Henndon Gordon Main

Chris Rowe Sasha Tetu Jessica Oliver

Wayne Appenzellar

Just as we’ve said “hello” to our new employees, so we’ve said goodbye to some others. We wish Masoweh Soheilian all of them well in their future endeavors.

Brad Alger, John Batko, Benjamin Bird, William Bird, Sonia P. Bisaccia, Tatiana Boronina, Janet Brown, Michelle Burke, Sandra Burkett, Pasquale Carzo, Charles Castle, Joseph Chichetti, Hye- Kyung Chung, Kathleen Curry, David Curtis, Sophie Destrau, Ashlee Michael Cosley, Dewees, Jan Drobeniuc, Diane Earp, Susan Ensel, Clarence Fisher, Kenneth Flook, Jeremy Foreman, Kristi Fox, Nancy Frazier, Garrett Funk, Sergey Grivennikov, José R. Hernandez, Leslie Hickman, Meenaxi Hiremath, David Hodge, Jeffrey Hodos, Jill Hood, Jennifer Hopkins, Joan Yanyu Wang Hopkins, Tyra House, Jia Qiang Huang, Rudy Ippordrino, Mary M. Janyszek, Lauren Jeffries, Ronald Keilholtz, Elena Klyushnenkova, Frank Knapik, Randy Knowlton, Lori Kobayashi, Alexey Korepanov, Sandeep Kumar, Sherry Lafferty, Mark Levanduski, Kevin Lewis, Wen Li, Demitrius Liepins, Sandra Loss, Andrew Makrigiannis, Kevin Masser, Sara Mayer, Karina Meragelman, Wojciech Miltyk, Dan Mioskie, Imbundu Namasaka, Orlando Ortega, Bonnie Osman, Jocelyn Pennella, Paola Perez, Howard Peters, Alfred Roca, Pier Ruffini, Janel Ruths, Mario Sanches, Glen Seidner, Naoko Seki, Carol Shawver, John Sharp, Karen Showalter, Mohammed Siddique, Mike Smiley, Nicole Smith, Catherine Sterner, Michael Stone, William Sutphin, Jenica Tapocik, Suneetha Porkkattil Thomas, Heng Yi Tao, Charles Trubey, Connie Tyser, Laura Waters, Kermit Weedon (deceased), Kenneth Wilkens, Debora Wolfe, Jimmy Yan, De Yang. ö

The NCI-Frederick Poster 3 January 2003 Charles River Laboratories (CRL)

Forbes Names million [based on several criteria] for new drugs, devices and therapies… CRL Chairman including sales growth, return on a broad and growing portfolio of “Entrepreneur of the Year” equity, and earnings per share.” biomedical products and services Mr. Foster attributed CRL’s success that enable customers to reduce Forbes Magazine recently named to the “hard work and dedication cost, increase speed, and enhance James C. Foster, Chairman and CEO of employees at every level of the productivity and effectiveness in drug of Charles River Laboratories (CRL), organization….an organization built discovery and development...[the] as “Entrepreneur of the Year.” Mr. on the principles of teamwork and customer base spans over 50 Foster was featured on the cover of the recognition.” countries, and includes all of the major annual “Best Small Companies” (Oct. CRL is headquartered in Wilmington, pharmaceutical and biotechnology 28) issue and in an accompanying Massachusetts, and provides “critical companies, as well as many leading feature story. research tools and integrated support hospitals and academic institutions. According to a recent CRL press services that enable innovative The company operates 76 facilities in release, the company placed 26th in and efficient drug discovery and 16 countries.” ö Forbes’ annual ranking of the top 200 development…[a] global leader in publicly traded USA companies “with providing the animal research models 12-month sales of less than $600 required in research and development

Data Management Services (DMS)

Web Design and is now offered year-round, enabling popular products and are already in Development Services C&SS to offer NCI-Frederick more wide use at the NCI-Frederick. They Expanded classes, including new courses and can now be freely obtained from the workshops, such as Adobe Acrobat, Computer Service Helpdesk. Data Management Services (DMS) FilemakerPro, and Microsoft Outlook. The NexTalk application, which recently has expanded its high- Perhaps the highlight of these new allows hearing-impaired persons to quality, Web-based solutions to the courses is a pre-requisite database communicate using a PC-based TTY NCI-Frederick community to include class C&SS designed, “Understanding system, is also available from the several individuals with commercial Relational Database Design,” as a Helpdesk. Web design and professional Web pre-requisite for all other database Contacting the Computer development experience. Recently classes, including Microsoft Access completed Web sites include the and FilemakerPro. C&SS developed Service Helpdesk redesigned NCI-Frederick and this customized class after a survey The Computer Service Helpdesk the Center for Cancer Research identified the need for a more acts as a single point of contact homepages, as well as 2002’s Take comprehensive introduction to for computer support, service, Your Child to Work Day site. database classes. Several custom information, and assistance to NCI- The Computer and Statistical classes were also requested and Frederick. Helpdesk staff are available Services’ (C&SS) Web Design and scheduled for individual areas. from 8:00 a.m. to 5:00 p.m., Monday Development team can assist you For questions about any of the through Friday, at: with your Web-based project, from consultative services, software conception and design to development, training, software products, or other • Web: implementation, maintenance, and information, call x1060. http://css.ncifcrf.gov/helpdesk enhancement. Remember–the quickest New Software Available way to a professional Web site is to • Phone: start with qualified Web designers; our C&SS, in conjunction with the 301-846-5115 skilled professionals are ready today to NIH, recently added EndNote and help you achieve your goals tomorrow. RefManager to the growing list of • E-mail: Changes in Computer software site-licensed for use at NCI- [email protected] ö Frederick. Used to find, organize, Software Training store, and retrieve bibliographical C&SS’ Computer Software Training citations and references, both are

The NCI-Frederick Poster 4 January 2003 SAIC-Frederick, Inc.

The Operations and The nine directorates include the identifies important contract matters Technical Support Research Technology Program (Dr. needing the attention of NCI. (OTS) Contract Joseph Kates, Director); Applied/ OTS Operating Developmental Research Support The 2001-2002 fiscal year was one Program (Dr. Michael Baseler); Committee of change as well as continued success Basic Sciences Program (Dr. Mary The OTS Operating Committee for SAIC-Frederick, Inc. For one Carrington); Biopharmaceutical establishes and recommends to the thing, SAIC was granted a second Development Program (Dr. George DEC for approval, operating policies and more comprehensive five-year Mitra); Laboratory Animal Sciences and procedures that streamline our Operations and Technical Support Program (Dr. Rick Bedigian); Vaccine administrative operations and result in Contract with the National Cancer Clinical Materials Program (Dr. Criss efficient contract performance. Institute at Frederick (NCI-Frederick), Tarr); Environment, Health, and Research Council with an option for the NCI to grant Safety Program (Dr. Randall Morin); a two-year extension; for another, Contracts and Administration (Mr. The Research Council was the Frederick campus company David Bufter); Facilities Management, established to give SAIC scientists was established as a wholly-owned Engineering and Planning (Mr. Bill a voice in all activities here at subsidiary, SAIC-Frederick, Inc. Lonergan). NCI-Frederick. As such this Whether you work for the NCI, Dedicated administrative teams Council provides a forum to advise Charles Rivers Laboratories (CRL), support each directorate. The teams management on issues important to the Data Management Services (DMS), are comprehensive, including accomplishment of the NCI-Frederick Wilson Information Services administrative staff from within that research mission. Corporation (WISCO), or SAIC- Directorate and representatives from SAIC-Frederick, Inc., has Frederick, Inc., chances are you’ve Human Resources, Financial and consistently scored in the heard references to the OTS Contract. Administrative Systems, Acquisition “Outstanding” award fee range. In But what is it exactly? How does it and Logistical Services, and the award fee period for September affect you? Facilities Management, Engineering 26, 2001, through March 25, 2002, You are affected simply by the fact and Planning. The teams ensure SAIC-Frederick, Inc., earned the that you work here, side by side with compliance with all applicable highest award fee score ever by an people from all the other companies Federal, state, and contractual OTS contractor in the history of NCI- under contract to the NCI. Through regulations and requirements. Frederick. established and new programs, our To resolve management, scientific, The score reflects NCI’s assessment partnership with the NCI provides and administrative issues, management of the quality, timeliness, and vital support to all of you in our joint committees have been created. Three efficiency of the research and mission to cure cancer and AIDS. committees, each with its own charter, support SAIC-Frederick, Inc., and The new contract has engendered offer opportunities for a diverse its employees provide. Dr. Arthur some changes, as SAIC-Frederick, and representative cross-section of believes the score demonstrates the Inc., has expanded to nine directorates employees to be involved in contract efforts of employees and the pride and management committees. Each management. they have in their work. He stated that directorate aligns with at least one Directors’ Executive “The Directors and staff are highly major NCI-Frederick Government motivated and are self-starters.” activity and “represents a unique Committee So, the next time you hear the term, subset of programmatic and The Directors’ Executive Committee “OTS contract,” remember that it’s administrative support” for the NCI- (DEC) comprises the nine Program helping you help others in the fight Frederick campus, Dr. Larry Arthur, Directors and provides overall against cancer and AIDS. ö Principal Investigator of the OTS contract-level guidance and planning; Contract and President for SAIC- solicits input from DEC members Frederick, Inc., said. The directorates on important matters related to the interact directly with you, providing overall contract; facilitates the transfer that operational and technical support of cross-directorate information; which “is essential to the successful reviews status reports from each of performance of the contract,” he the Directorates; refers specific tasks added. to the OTS Operating Committee; and

The NCI-Frederick Poster 5 January 2003 Wilson Information Services Corporation (WISCO)

About WISCO continues in the role she has held since Alice Young became our Serials August 1984 as the Library’s full-time Librarian in 1986; Like everyone at NCI-Frederick, resident Project Manager. WISCO she now works in our library staff adapted to changes continues to be a family enterprise Technical Services in September 2001. One change with Sue’s son, Nate, now Personnel department part-time. specifically affected them, though, Administrator for the corporate office. Having graduated since the Wilson Information Services from the Marine Corps Corporation (WISCO) was awarded WHO’s WHO officers’ training camp the Scientific Library Contract that at Quantico, VA, she same month. Within two weeks, At least some things didn’t change almost chose the military instead of everyone completed the transfer in September 2001–friendly, familiar the library profession. process, received new ID cards, signed faces still greet you when you come up for new benefits, and even received in the Library door. WISCO employs Our Systems Librarian, Steve Jones, new paychecks. 22 people to provide library services first joined us December 2, 1987, to NCI-Frederick, quite an increase to perform online The owner of the newest company from the small staff of four when the searches for our in our community isn’t a stranger to Library opened its doors 30 years ago. chemists in those days NCI-Frederick. Sue Wilson, president We’ll highlight some of our people in when no one had a and CEO of WISCO, this issue and more in the spring. desktop computer. worked with Litton His work has always Bionetics from 1974 Darlene Clements, who handles our involved the sciences, to 1978; in all she has photocopying, has and he still wonders worked for 26 years been with the Library what ever happened at NCI-Frederick. longer than any other to his first class of senior high biology After leaving in SciLib staff member; students after they graduated. 1978, Sue moved she began working at to Los Angeles and formed a sole- NCI-Frederick almost August 8, 1988, is Robin Meckley’s proprietorship library consulting 30 years ago. anniversary date. While working here practice, with a client base consisting full-time, she earned primarily of small hospitals. Initially, Ethel Armstrong likes working in the her Master’s Degree WISCO services included literature Library so much, she’s in Library Science searches, library facilities design been driving for an from the University of and building programs creation, core hour to get here every Maryland. Robin still collections set ups, and plans for day since August 10, enjoys the classroom, library staff training and organizational 1982! Even after all and plans many of programs for these institutions. that driving, Ethel the Library’s training Soon, however, Sue longed for the loves to travel, and has programs as our rolling, green farmland of her native visited every continent Instructional Resources Librarian. Frederick County and returned to NCI- but Africa. Frederick as Assistant Director of the Scientific Library. Visit the NCI-Frederick Web site: http://web.ncifcrf.gov/ThePoster to learn more After her return to Frederick, Sue and about these helpful WISCO staffers. ö her husband, Howard, included other services such as appraising private Library collections, manuscript proofing, legal and market research, scientific test Trivia result illustration, searching for out- Do you know how of-print books, and retrieving general much subscriptions information for use by the public. to medical journals

While WISCO has several new have changed over Subscription opportunities, NCI-Frederick is the past 50 years? Average Yearly WISCO’s primary concern, and Sue

The NCI-Frederick Poster 6 January 2003 Science Today

Reflections on the on resources and personnel, with new, Without the NCI and BDP assuming Evolution of the BDP more complex projects needing greater the initial risk of demonstrating the [Editor’s Note: Our Science Today editor, kinds and amounts of material than potential benefits of new therapies, Dr. Steven Giardina, SAIC-Frederick, Inc., originally envisioned. Some projects many of these molecules might not Biopharmaceutical Development Program, has, needed additional development to have been brought to trial. In the past among other accomplishments, successfully pass the FDA’s rigorous scrutiny for year alone, the BDP has produced 54 managed the development of several product purity and activity. Thus, the lots of material for use in non-clinical recombinant immunotoxins for the treatment of BDP quickly evolved from a simple studies and for human clinical trials. B-cell leukemias which have progressed past Phase I clinical trials.] manufacturing facility to a national In light of recent events, the resource, working with the discovery United States must develop new Twenty years ago, decoding human scientist to develop and manufacture vaccines against potential biological chromosome (i.e., the genome) DNA cutting-edge biological drugs. weapons. Thus, under an interagency seemed as realistic as Star Trek’s Where the BDP’s predecessor agreement between the Departments Captain Kirk ordering, “Beam me comprised 12 employees, working in of Defense and Health and Human up, Scottie.” Yet not only was DNA a trailer behind the Café/Conference Services, the BDP has helped decoded, it was completed earlier than Center, now the BDP includes develop a vaccine against Venezuelan predicted. more than 130 scientists, engineers, Equine Encephalitis virus (VEE) The same molecular biology and technicians, and administrators in and has produced a clinical lot of computer technology advances 10 buildings. Where once a single VEE vaccine. In addition, a second- responsible for this achievement now laboratory provided purification and generation anthrax vaccine, composed focus on the next critical question: assay development, now several do. of a highly purified recombinant “What do all these genes do?” The BDP now can produce products protein, has been produced for the The production and analysis of the in mammalian cells needing 250-liter National Institute of Allergy and products of these genes are integral tanks of media. Bacterial fermentation Infectious Diseases for evaluation as to proteomics, a new research area capacity runs from small shake flasks an alternative to the currently licensed which holds promise for new cancer to a 3,000-gallon fermenter. Products vaccine. The BDP has provided not and disease therapies, more effective can be purified in a “clean” room only its manufacturing capacity to prophylactic vaccines, and correction that also boasts an automatic vial- these important projects but also its of genetic defects and abnormalities. filling machine. In addition, the BDP expertise in product development, However, moving from the has separate Quality Assurance and quality assurance, and quality control. “bench” to the marketplace is long Quality Control groups to assess the The BDP is only one of the NCI- and expensive, since identifying a products’ manufacturing process, the Frederick programs and laboratories clinically useful biological drug can facilities, and equipment. engaged in exciting and important be arduous and inefficient. Thus, Projects now come from many research, an effort supported by to more efficiently translate new, sources, including university the many members of our campus exciting discoveries into potential new laboratories across the country. community. Future articles will therapies, the National Cancer Institute Biological entities include natural highlight other research efforts and (NCI) created the Biopharmaceutical products, monoclonal antibodies, achievements. Development Program (BDP). recombinant proteins, DNA plasmids, Now operated by SAIC-Frederick, viral vaccines, and gene therapy Recent Articles: Inc., under the direction of Dr. products. The BDP has produced Coffman JD, et al., Production and purification Gautam Mitra, at its inception the fragments of antibodies with attached of a recombinant staphylococcal enterotoxin B vaccine candidate expressed in Escherichia BDP had modest goals. The BDP toxins; these antibodies show great coli. Protein Expr. Purif. 24:302-312, 2002. would emphasize manufacturing a promise for treating some forms of few scientifically worthy candidates leukemia and lymphoma. The five- Fry TJ, et al., IL-7 therapy dramatically alters in compliance with current Good year-old RAID (Rapid Access to peripheral T-cell homeostasis in normal and Manufacturing Practices so the Food Intervention Development) Program SIV-infected non-human primates. Blood, in and Drug Administration (FDA) continues to identify even more press. would allow the products to be tested, new and exciting therapies. Several Giardina SL: Chap. 25: Basic strategies for and released for human clinical safety products have already advanced to the purification of recombinant proteins.Gene trials at the main Bethesda campus. being tested in collaboration with a Transfer and Expression in Mammalian Cells. Initial success increased demands corporate partner. Accepted for publication (Oct. 2002). ö

The NCI-Frederick Poster 7 January 2003 Platinum Highlight

Each quarter, The Poster lists some Biragyn A., Ruffini P.A., Leifer C.A., Klyushnenkova E., Shakhov A., of the most relevant recently-published Chertov O., Shirakawa A.K., Farber J.M., Segal D.M., research articles by NCI-Frederick Oppenheim J.J., and Kwak L.W. scientists (see “Platinum Publications” Toll-like receptor 4-dependent activation of on the next page). In addition, we will summarize one that we believe is dendritic cells by β-defensin 2 especially significant. This quarter’s Science 298(5595):1025-1029, 2002 highlight article is by Dr. Arya Biragyn and colleagues. Dr. Biragyn β-defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR- 4), inducing up-regulation of co-stimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

is a staff scientist in the laboratory of Dr. Larry Kwak, principal investigator, Experimental Transplantation and Immunology Branch, NCI. Dr. Kwak has a broad range of scientific and clinical interests, spanning tumor immunology, cancer vaccines, adoptive T-cell therapy, and management of lymphomas and myelomas. He serves as co-chair of the DCS Cancer Vaccine Working Group (nonmelanoma).

For the complete article and references, please log on to http://www.sciencemag.org/content/ vol298/issue5595/index.shtml

The NCI-Frederick Poster 8 January 2003 Platinum Publications

The following articles have been selected of patients with HIV infection. Natarajan Farnet, JS Thorson. Science, 297(5584): from a quarterly listing of publications in V, RA Lempicki, I Sereti, Y Badralmaa, 1173-1176, 2002. the top ten science journals. JW Adelsberger, JA Metcalf, DA Prieto, R Stevens, MW Baseler, JA Kovacs, HC Notl subtraction and Notl-specific AIDS Research Lane. Proc Natl Acad Sci USA, 99(16): microarrays to detect copy number DNA vaccines encoding Human Im- 10712-10717, 2002. and methylation changes in whole ge- munodeficiency Virus-1 glycoprotein nomes. Li JF, A Protopopov, FL Wang, V 120 fusions with proinflammatory Long-term effects of intermittent Senchenko, V Petushkov, O Vorontsova, L chemoattractants induce systemic and Interleukin 2 therapy in patients with Petrenko, V Zabarovska, O Muravenko, E mucosal immune responses. Biragyn A, HIV infection: Characterization of a Braga, L Kisselev, MI Lerman, V Kashu- IM Belyakov, YH Chow, DS Dimitrov, novel subset of CD4(+)/CD25(+) T cells. ba, G Klein, I Ernberg, C Wahlestedt, ER JA Berzofsky, LW Kwak. Blood, 100(4): Sereti I, H Martinez-Wilson, JA Metcalf, Zabarovsky. Proc Natl Acad Sci USA, 1153-1159, 2002. MW Baseler, CW Hallahan, B Hahn, RL 99(16):10724-10729, 2002. Hengel, RT Davey, JA Kovacs, HC Lane. Structures of the complexes of a potent Blood, 100(6):2159-2167, 2002. New genes involved in cancer identi- anti-HIV protein cyanovirin-N and fied by retroviral tagging. Suzuki T, HF high mannose oligosaccharides. Botos Apoptosis Shen, K Akagi, HC Morse, JD Malley, DQ I, BR O’Keefe, SR Shenoy, LK Cartner, An ATF2-derived peptide sensitizes mel- Naiman, NA Jenkins, NG Copeland. Nat DM Ratner, PH Seeberger, MR Boyd, A anomas to apoptosis and inhibits their Genet, 32(1):166-174, 2002. Wlodawer. J Biol Chem, 277(37):34336- growth and metastasis. Bhoumik A, TG 34342, 2002. Huang, V Ivanov, L Gangi, RF Qiao, SLC Immunology Woo, SH Chen, Z Ronai. J Clin Invest, Bacteria-triggered CD4(+) T regulatory Direct and indirect contributions of 110(5):643-650, 2002. cells suppress Helicobacter hepaticus-in- RNA secondary structure elements to duced colitis. Kullberg MC, D Jankovic, the initiation of HIV-1 reverse tran- Apo cytochrome C blocks Caspase-9 PL Gorelick, P Caspar, JJ Letterio, AW scription. Goldschmidt V, M Rigourd, C activation and Bax-induced apoptosis. Cheever, A Sher. J Exp Med, 196(4):505- Ehresmann, SF Le Grice, B Ehresmann, R Martin AG and HO Fearnhead. J Biol 515, 2002. Marquet. J Biol Chem, 277(45):43233- Chem, October 18 [epub ahead of print] 43242, 2002. 2002. Protein Chemistry (-)-Doliculide, a new macrocyclic dep- Amino acid deletions are introduced Cytokines sipeptide enhancer of Actin assembly. into the V2 region of Gp120 during Crystal structure of Interleukin-19 Bai RL, DG Covell, CF Liu, AK Ghosh, independent pathogenic Simian Im- defines a new subfamily of helical cyto- E Hamel. J Biol Chem, 277(35):32165- munodeficiency Virus/HIV chimeric kines. Chang C, E Magracheva, S Kozlov, 32171, 2002. virus (SHIV) infections of Rhesus S Fong, G Tobin, S Kotenko, A Wlodawer, monkeys generating variants that are A Zdanov. J Biol Chem, October 25 [epub The dual specificity JKAP specifically macrophage tropic. Imamichi H, T ahead of print] 2002. activates the C-Jun N-terminal kinase Igarashi, T Imamichi, OK Donau, Y Endo, pathway. Chen AJ, GS Zhou, T Juan, SM Y Nishimura, RL Willey, AF Suffredini, Cyclosporin A blocks the expression of Colicos, JP Cannon, M Cabriera-Hansen, HC Lane, MA Martin. Proc Natl Acad Sci lymphotoxin alpha, but not lympho- CF Meyer, R Jurecic, NG Copeland, USA, 99(21):13813-13818, 2002. toxin beta, in human peripheral blood DJ Gilbert, NA Jenkins, F Fletcher, TH mononuclear cells. Kuprash DV, VE Tan, JW Belmont. J Biol Chem, 277(39): Epistatic interaction between KIR3DS1 Boitchenko, FO Yarovinsky, NR Rice, A 36592-36601, 2002. and HLA-B delays the progression to Nordheim, A Ruhlmann, SA Nedospasov. AIDS. Martin MP, XJ Gao, JH Lee, GW Blood, 100(5):1721-1727, 2002. Nm23-H1 metastasis suppressor phos- Nelson, R Detels, JJ Goedert, S Buchbind- phorylation of kinase suppressor of Ras er, K Hoots, D Vlahov, J Trowsdale, M Genetics via a histidine protein kinase pathway. Wilson, SJ O’Brien, M Carrington. Nature The calicheamicin gene cluster and its Hartsough MT, DK Morrison, M Salerno, Genetics, 4:429-434, 2002. iterative type I enediyne PKS. Ahlert J, D Palmieri, T Ouatas, M Mair, J Patrick, E Shepard, N Lomovskaya, E Zazopoulos, PS Steeg. J Biol Chem, 277(35):32389- Increased peripheral expansion of naive A Staffa, BO Bachmann, KX Huang, L 32399, 2002. CD4+T cells in vivo after IL-2 treatment Fonstein, A Czisny, RE Whitwam, CM

The NCI-Frederick Poster 9 January 2003 Platinum Publications

The structure of human macrophage Montgomery, R Sheridan, R Blake, LA Histidyl-Trna synthetase and Aspa- inflammatory protein-3 alpha/CCL20– Smith, JD Marks. Proc Natl Acad Sci raginyl-Trna synthetase, autoantigens linking antimicrobial and CC chemo- USA, 99(17):11346-11350, 2002. in myositis, activate chemokine recep- kine receptor-6 binding activities with tors on T lymphocytes and immature human beta defensins. Hoover DM, Structural basis for the substrate dendritic cells. Howard OMZ, HJF Dong, C Boulegue, D Yang, JJ Oppenheim, K specificity of tobacco etch virus prote- D Yang, N Raben, K Nagaraju, A Rosen, Tucker, WY Lu, J Lubkowski. J Biol ase. Phan J, A Zdanov, AG Evdokimov, L Casciola-Rosen, M Hartlein, M Kron, K Chem, 277(40):37647-37654, 2002. JE Tropea, HK Peters 3rd, RB Kapust, M Yiadom, S Dwivedi, PH Plotz, JJ Oppen- Li, A Wlodawer, DS Waugh. J Biol Chem, heim. J Exp Med, 196(6):781-791, 2002. Transcriptional activity of CCAAT/ 107(1):October 10, 2002. [epub ahead of enhancer-binding proteins is controlled print] SNT1/FRS2 mediates germinal vesicle by a conserved inhibitory domain that breakdown induced by an activated is a target for sumoylation. Kim J, CA Crosstalk between BCR/ABL oncop- FGF receptor1 in Xenopus oocytes. Cantwell, PF Johnson, CM Pfarr, SC Wil- rotein and CXCR4 signaling through Mood K, R Friesel, IO Daar. J Biol Chem, liams. J Biol Chem, 277(41):38037-38044, a Src family kinase in human leuke- 277(36):33196-33204, 2002. 2002. mia cells. Ptasznik A, E Urbanowska, S Chinta, MA Costa, BA Katz, MA Stan- Increased bone marrow allograft rejec- Identification of Glis1, a novel Gli-re- islaus, G Demir, D Linnekin, ZK Pan, tion by depletion of NK cells expressing lated, Kruppel-like zinc finger protein AM Gewirtz. J Exp Med, 196(5):667-678, inhibitory Ly49 NK receptors for donor containing transactivation and repres- 2002. class I antigens. Raziuddin A, DL Longo, sor functions. Kim YS, M Lewandoski, M Bennett, R Winkler-Pickett, JR Ortaldo, AO Perantoni, S Kurebayashi, G Na- Fusion proteins with COOH-terminal WJ Murphy. Blood, 100(8):3026-3033, kanishi, AM Jetten. J Biol Chem, 277(34): ubiquitin are stable and maintain dual 2002. 30901-30913, 2002. functionality in vivo. Qian SB, DE Ott, U Schubert, JR Bennink, JW Yewdell. J Biol Heterologous desensitization of opioid The phage {Lambda} CII transcrip- Chem, 277(41):38818-38826, 2002. receptors by chernokines inhibits che- tional activator carries a C-terminal motaxis and enhances the perception domain signaling for rapid proteolysis. Synaptic defects in Ataxia mice result of pain. Szabo I, XH Chen, L Xin, MW Kobiler O, S Koby, D Teff, D Court, AB from a mutation in Usp14, encoding a Adler, OMZ Howard, JJ Oppenheim, TJ Oppenheim. Proc Natl Acad Sci USA, ubiquitin-specific protease. Wilson SM, Rogers. Proc Natl Acad Sci USA, 99(16): October 23, 2002. [epub ahead of print] B Bhattacharyya, RA Rachel, V Cop- 10276-10281, 2002. pola, L Tessarollo, DB Householder, CF Stabilities and conformations of Al- Fletcher, RJ Miller, NG Copeland, and NA Initial characterization of TREM-like zheimer’s beta-amyloid peptide oligo- Jenkins. Nat Genet, 32(3):420-425, 2002. transcript (TLT)-1: A putative inhibi- mers (Abeta 16-22, Abeta 16-35, and tory receptor within the TREM cluster. Abeta 10-35): Sequence effects. Ma B Homologues of human macrophage Washington AV, L Quigley, DW McVicar. and R Nussinov. Proc Natl Acad Sci USA, migration inhibitory factor from a para- Blood, 100(10):3822-3834, 2002. 99(22):14126-14131, 2002. sitic nematode. Zang X, P Taylor, JM Wang, DJ Meyer, AL Scott, MD Walkin- Mistargeting hippocampal axons by The effects of adrenomedullin overex- shaw, RM Maizels. J Biol Chem, 277(46): expression of a truncated Eph receptor. pression in breast tumor cells. Martinez 44261-44267, 2002. Yue Y, ZY Chen, NW Gale, J Blair-Flynn, A, M Vos, L Guedez, G Kaur, Z Chen, M TJ Hu, X Yue, M Cooper, DP Crockett, Garayoa, R Pio, T Moody, WG Stetler-Ste- Receptors GD Yancopoulos, L Tessarollo, RP Zhou. venson, HK Kleinman, F Cuttitta. J Natl Toll-like receptor 4-dependent activa- Proc Natl Acad Sci USA, 99(16):10777- Cancer Inst, 94(16):1226-1237, 2002. tion of dendritic cells by beta-defensin 10782, 2002. ö 2. Biragyn A, PA Ruffini, CA Leifer, E Potent neutralization of botulinum Klyushnenkova, A Shakhov, O Chertov, neurotoxin by recombinant oligoclonal AK Shirakawa, JM Farber, DM Segal, antibody. Nowakowski A, C Wang, DB JJ Oppenheim, LW Kwak. Science, Powers, P Amersdorfer, TJ Smith, VA 298(5595):1025-1029, 2002.

The NCI-Frederick Poster 10 January 2003 Environment, Health, and Safety Program

What do you know about the flu and colds?

True or false? Answers below.

1. December is too late to get a flu shot. 2. The shot can give you the flu. 3. Even if I get a flu shot, I can still get the flu. 4. The side effects are worse than the flu. 5. Not everyone can take the flu shot. 6. Only the very old and sick need the Looking Back: Public Health Initiatives flu shot.

Flu (influenza) shots were given on the last three days of October, with a make- Answers: up day on November 13. Occupational Health Services (OHS) staff traveled to 1. False: The flu shot can be given Bethesda and Gaithersburg on November 1 to provide vaccinations to those who before or during the flu season. support the NCI off-site. As usual, 1,000 doses of flu vaccine were ordered last While the best time to get a flu shot February; mechanisms are in place to procure more, if needed. is October or November, a flu shot in Providing flu vaccinations free of charge to employees, students, and December or later will still protect you against the flu. volunteers is only one of the public health initiatives that OHS takes on 2. False: Flu vaccines are made from annually. Other free services in this category include tetanus/diphtheria killed influenza viruses. These viruses vaccinations, the travel medicine program, and many wellness initiatives. To cannot give you the flu. schedule an appointment, call x1096 between 9:30 a.m. and 4:30 p.m. ö 3. Maybe: This can happen, but the flu shot usually protects most people from the flu. However, the flu shot will not protect you from other viruses that can NCI-Frederick Ergonomics cause illnesses that sometimes feel like the flu. What is ergonomics? Ergonomics is the science of fitting 4. False: The worst side effect you’re the job to the worker–resulting in greater comfort and less likely to get is a sore arm. The risk of chance for injury to workers as well as a more productive a rare allergic reaction is far less than the risk of severe complications from workplace! influenza. How can the Environment, Health, and Safety Program 5. True: If you are allergic to eggs (EHS) help improve ergonomics in your workplace? The (used in making the vaccine); are very EHS Ergonomics Program seeks to prevent ergonomic injuries (such as carpel ill with a high fever; or have had a tunnel syndrome) through proactive measures, including work-site evaluations, severe reaction to the flu vaccine in the training, consulting, and early intervention programs. past, you might not be able to get this When EHS conducts a work-site evaluation, potential ergonomic hazards in protection. the workplace are identified. As a result of a work-site evaluation, EHS educates 6. False: Both adults and children employees and supervisors with the goal of enabling each department to practice who are in good health need a flu shot good ergonomic principles and work habits. EHS also helps departments make to stay healthy. Even if you aren’t at site-specific decisions on procuring ergonomic equipment, furniture, and tools. high risk of complications, you should Check out the links on the Occupational Health Services (OHS) Web page for get a flu shot to prevent the flu and to protect everyone you live with and ergonomic information on workstations, computing, injuries, and publications at contact. http://home.ncifcrf.gov/ohs/ergo.html. Early intervention is key to preventing ergonomic injuries. If you are Visit the NCI-Frederick Web site: http: experiencing any discomfort or pain at work, please contact OHS at x1096 for //web.ncifcrf.gov/ThePoster for more medical management. For more information on ergonomics, or to schedule an flu information. ergonomic work site evaluation, please contact EHS at x1451. ö

The NCI-Frederick Poster 11 January 2003 Did You Know...?

A Blast from the Past

Do you recognize these people? We’ve identified all but one person. A blast from the past: The [1972?] softball team. Back row, left to right: Kikuo Onozaki, Larry Brown, Rick Stauffer, Jim Lenhart, Roy Walker, Paul Miller, and Robert Wiltrout. Front row: Bill Bond, Gerry Princler, unidentified, John Ortaldo, Jeff Rossio, Charles Morgan, and Craig Reynolds. ö

Campus ATM Machine Now Operational Free Flu Shots You can now access the campus Comstar Federal Credit Union Automated Teller Machine (ATM). Located in the vestibule of Building 549, it is available Monday-Friday, 6:30 a.m.-5:00 p.m. The ATM dispenses money in $5, $10, and $20 denominations and accepts Comstar Credit Union ATM cards, major credit cards, and ATM cards on the Alliance One, Cirrus, Plus, and Star systems. ö

Library Staff Retreat What better time to get zapped with that needle than Halloween? Pictured above is nurse Kitty Nalewaik giving a flu shot as her patient bravely smiles. ö

Do you have two forms of photo ID? ö

Scientific Library staff recently celebrated their busy first year under the new WISCO contract with a two-day staff retreat at Stone Manor in Middletown. Through brainstorming sessions, lessons on communication theory, exercises in developing mutual respect and trust, the staff focused on strategic planning and team building, furthering their commitment to service excellence, and emerged with a set of 12 new objectives. Shown above, WISCO staff build team spirit through an exercise in mutual trust. ö

The NCI-Frederick Poster 12 January 2003 Did You Know...?

Find Your Friends on the World Map in the NCI-Frederick Café

To promote a sense of community on the NCI-Frederick campus, the Frederick Employee Diversity Team (F-EDT) recently placed a world map and a sign-in book next to its display case located in the NCI-Frederick Café (Building 549). Ms. Shannon Bell, chairperson of the F-EDT, said, “We hope each Fort Detrick community member takes the time to at least see the map. It is really impressive to realize that the pins represent people from diverse backgrounds and cultures who live and work in our community that come from all of the wonderful places from around the world.” ö Spirit of Support

Thirty Year Celebration Edition The Poster will publish a special Thirty-Year Celebration edition to commemorate the last 30 years of NCI-Frederick. If you are like many of us, you have a couple of photo albums or a shoebox filled with old pictures and a ton of memories. Share your memories with us by sharing your pictures. So, grab a cup of coffee, pick out your favorite photos, and bring them to Scientific Publications, Graphics and Media (SPGM), Building 362. We will copy the photographs and return them to you. We’ll incorporate as many as possible into the Thirty-Year Celebration edition of The Poster. For further information, call Maritta Grau, SPGM editor, x1055. ö

In the spirit of support for our Ft. Detrick soldiers and their compatriots in the Middle East, SAIC-Frederick, Inc. and the National Cancer Institute have installed a 20 x 12 foot American flag on one of their Our intrepid photographer recently shot this picture of a snowy NCI- most prominent structures. ö Frederick campus from the roof of Building 535. ö

The NCI-Frederick Poster 13 January 2003 Community Outreach

Hands-On Experience for with the Frederick County Public School System and signing of an agreement Future Scientists between NCI-Frederick and the Frederick County Public School System on November 9, 1999. NCI-Frederick constantly looks for meaningful ways to partner with the Frederick community. One of the most exciting is the Elementary Outreach Program, in which NCI-Frederick scientists, administrators, and support personnel introduce the county’s children to science through unique, hands-on experiences. In a recent interview, Dr. Robert Wiltrout, Associate Director of the NCI-Frederick, called this “a visionary…program,” sending our scientists “to teach kids, probably for the first time, about the scientific method and the excitement of scientific discovery.” From One Classroom to Many Dr. Michael Dean, Chief, Human Genetics Section, Laboratory of Volunteers Provide Unique Experiences Genomic Diversity, Division of Basic NCI-Frederick volunteer teams provide children with experiences involving scientific expertise and equipment not normally available within the elementary schools. The lessons complement the school curriculum and are coordinated with school and system administrators. Making students aware of careers in scientific research and other science- related fields is also an important aspect of the program. Since volunteers are from both administrative and scientific areas, the students usually realize that they do not necessarily have to be “bench” scientists to have careers in science. By the 1999-2000 school year, a full program was presented at Hillcrest, Dr. Dean with his daughter, the third of covering every class for grades 1 through 5; and the volunteer teams also his children in the program at Hillcrest presented their modules to selected classes and grades at several other schools. Elementary School. That first year, the 30 volunteers provided more than 800 hours; two years later, in 2001-2002, the number of volunteers had more than doubled to 68 and Science, NCI, was the originator of volunteer hours to a phenomenal 2,187 (see table below). this program, begun informally when his son was a student at Frederick’s 2000-2001 2001-2002 Hillcrest Elementary School. The Number of schools 8 18 children’s and teachers’ enthusiastic Number of classes 64 141 response inspired Dr. Dean to continue Number of students 1586 3300 work with students at Hillcrest, even Number of volunteers 37 68 after his son had finished elementary Number of volunteer hours 1119 2187 school. Eventually, at Dr. Dean’s request, Amount of FUN and LEARNING for both students and volunteers: NCI-Frederick became involved, resulting in a formal partnership IMMEASURABLE

The NCI-Frederick Poster 14 January 2003 Community Outreach

Sessions are taught through April or May. Some of the volunteers even take Keep in Touch the program, on their own initiative, to their local schools outside of Frederick County or to private schools within the County. An Elementary Outreach Program By the end of the 2002-2003 school year, the current 92 volunteers hope to Web site is being planned to include have visited every Frederick County public elementary school at least once since photographs of the teams in action, the Program’s inception. some of the thank-you notes, lesson plans, and information about the program. For additional information regarding the Elementary Outreach Program, please call Barbara Birnman, x1956. You may volunteer electronically: at the NCI-Frederick home page, click on Campus Resources, then on Outreach and Special Programs, which will take you to the Elementary Outreach Program Volunteer Form. Sign up at Volunteers Schedule Two Days a Year any time to join one of the teams. ö

The Program is refined from year to year, with schedules finalized by the end of October so that each team visits only one school a month. Although volunteers are asked to contribute only two days the entire school year, many volunteer more often once they find out how rewarding the Program is. Since the NCI-Frederick and its four contractors support the Elementary Outreach Program, volunteers do not have to use personal leave to participate; however, participation should not impose on work schedules, and volunteers must have approval from their supervisors. Kudos from the Classroom Feedback is always important, whether it’s concerning our jobs or some other aspect of our lives. A couple of years ago, the Fifth Grade Team presented a lesson and were concerned that one child might be bored because while he participated, he never spoke. However, at the end of the session, the quiet child was the first to raise his hand. His comment? “This program kicks butt!” The children’s thank-you notes are passed among team members and then maintained in scrapbooks. The children’s incredible enthusiasm and imagination make these wonderful notes priceless.

The NCI-Frederick Poster 15 January 2003 Frederick Employee Diversity Team

New Year’s Celebrations Mecca to Yathrib, now known as various ways across the four regions Around the World Medina (a contraction of Medinat of India and in several countries near al-Nabi, or City of the Prophet), India, such as Cambodia, Laos, Sri 200 miles north of Mecca to evade Lanka, and Thailand. persecution. Muslims call this migration in 622 c.e. (the Common Japanese New Year Era, used by many scholars in place New Year’s day, Osho-gatu, is of the Christian-oriented BC/AD) the probably the most important holiday in hijra; it is regarded as the birth of the Japan. People return home for a couple independent Islamic community. Thus, of days to celebrate with family, just as the Western year of 622 c.e. is the first Americans do at Christmas. Although year of the Islamic calendar. this celebration used coincide with the Chinese holiday in February, now New Jewish New Year Year’s Day is observed January 1st. The Jewish New Year, Rosh In midnight services, many people Hashanah, literally means “head of pray at shrines or temples, where the Have you just celebrated the the year” and commemorates the priest strikes a bell 108 times, based new year? Made those new year’s anniversary of the creation of the on the belief that the people need to resolutions? Although for many of us world. Based on the Jewish lunisolar rid themselves of 108 worldly passions January 1st marks the start of a new calendar established by Hillel II, it from the previous year. year, for some NCI-Frederick staff, the is celebrated on the first and second Typical foods for the New Year’s day new year arrives at a different time on days of the Hebrew month, Tishri, celebration include osechi-ryori, small the Gregorian calendar. occurring in early fall. pieces of cooked beans, vegetables, Chinese New Year Rosh Hashanah includes numerous meat, and seafood; and mochi, a cake ancient traditions, the most important of sticky white rice, either baked or The Chinese New Year, Yuan Tan, being that, during the 10 days between put in soup. is celebrated on the first new moon Rosh Hashanah and the Day of between January 21 and February 20. Atonement, or Yom Kippur, Jews Kwanzaa Many of Chinese ancestry conduct account for their behavior during Not strictly limited to a celebration spectacular New Year processions the past year, seek forgiveness from of the new year, the seven-day, secular with dancing “dragons” (symbols those they may have wronged, and Kwanzaa begins on December 26th of longevity and wealth), and think about how to live a better life. and ends January 1st. Initiated shortly dedicated to bringing everyone good At synagogue services, the shofar, after the LA/Watts riots of 1966 luck, health, happiness, and wealth. or ram’s horn, is blown to signal the in the midst of the Black Freedom Exploding firecrackers startle evil beginning of the New Year. Movement in the US, Kwanzaa spirits and dispel bad luck. Money, The ceremonial New Year meal acknowledges the African-American placed in red envelopes with good- includes traditional foods, such as heritage and celebrates family, luck messages written in gold, is fresh fruits, especially apples and community, and culture. The name usually given to children in the giver’s grapes; braided bread, or challah; and Kwanzaa derived from the phrase family. honey cakes. matunda ya kwanzaa, meaning “first fruits” in Swahili, the most widely Islamic New Year Hindu New Year spoken African language. Kwanzaa’s The Islamic New Year marks the end India follows the Western Gregorian colors, black, red and green, are of Ramadan (the fasting month) and is calendar for government and incorporated into traditional African a quiet, religious observance, during commercial business, but many Indian decorations, such as baskets, cloth, which the new moon is noted with festivals are based upon ancient art objects, and harvest symbols. In special prayers in mosques. traditions. One such festival is the addition, the colors are featured in An essential Islamic New Year Hindu New Year, the November the central symbol of Kwanzaa, the tradition is recounting the Prophet festival of Diwali, which signifies kinara (candle holder), which supports Muhammad’s and his followers’ the renewal of life and proclaims the one black, three red, and three green eight-day flight and migration from approach of winter and is celebrated candles, symbolizing the seven

The NCI-Frederick Poster 16 January 2003 Frederick Employee Diversity Team principles of Kwanzaa: unity, self- Diversity Café—Exploring family might enjoy this.’ If this person determination, collective work and Diversity through Cinema watches it with his or her family and responsibility, cooperative economics, that leads to a conversation around the purpose, creativity, and faith. The Frederick Employee Diversity dinner table, then I would consider the European New Year Team (F-EDT), in conjunction with program a success,” said Mr. Miller. the SCILIB Theater, sponsors free Movies are shown free in their Traditions noontime movies in the Building 549 entirety on two consecutive days, While traditions vary from country to Auditorium. Paul Miller, who runs usually the last Mondays and Tuesdays country in Europe, similarities abound. this program for the F-EDT, explained of the month, and are open to all Fort For example, in Greece, the new the seven-month-old program: “Our Detrick employees. Eating is permitted year is celebrated by visiting friends motto, ‘Exploring Diversity through in the Building 549 Auditorium. and relatives, exchanging gifts, and Cinema,’ I think, captures the intent of The F-EDT is always on the lookout delighting in food, drink and music. this effort. Movies can be a powerful for movies that might appeal to the Traditional foods symbolic of mechanism to gain a glimpse into NCI-Frederick community, so if you happiness and wealth include honey, how individuals from other worlds have a movie to recommend, e- nuts, and fresh fruit; but the most and cultures cope with their changing mail your suggestion to Paul Miller, important is vassilopitta, or St. Basil’s worlds. Certain themes, such as fear, [email protected]. Movies should cake, in which is baked a gold coin. love, hope, self-doubt, and self- be appropriate for viewing in the work Whoever finds the coin in his or her discovery, are universal and cross place and no longer than two hours. ö piece of cake will be lucky for the next cultural and language barriers. Also, year. the role of interpersonal relationships, Display Case Features January 1st is particularly important particularly the ways families from Monthly Exhibits to Greeks because it celebrates both different cultures relate to and support New Year’s Day and St. Basil’s Day. each other, offers an important The F-EDT display case in the St. Basil was a forefather of the Greek lesson.” Building 549 Café provides intriguing Orthodox Church. Movies in this series have run the exhibits that change every 4-8 weeks; Finally, in ancient Ireland, the Celtic gamut from comedy to drama and the exhibits display artifacts and New Year festival known as Samhain include Glory, Avalon, Gorillas in information about a region of the represented the harvest and storage of the Mist, The Matchmaker, Crossing USA, different crops for the coming winter. Samhain Delancey, Remember the Titans, and countries, was celebrated at the end of October; Monsoon Wedding. The Café often and cultures. the festival has survived as Halloween. features a film highlighting a selected For example, However, many who follow Wicca group. For example, Glory, about the to celebrate continue to observe Samhain (also 54th Regiment, an all Black unit of the recent called Ancestor Night) on October 31 the Massachusetts Volunteer Infantry December as their spiritual New Year. at the Battle of Fort Wagner during holiday season, the American War Between the States, more than 20 Did we miss you? was shown during African American dolls from If so, please let us know how you History Month; Gorillas in the Mist, several different celebrate the New Year. We’ll add based on the autobiographical 1983 cultures were on details or correct errors on the book by naturalist Dian Fossey, was display. NCI-Frederick Web site: http:// shown to celebrate Women’s History The February web.ncifcrf.gov/ThePoster. ö Month. In addition to the movies 2003 display will highlight Black shown, the Library also provides a list History Month, featuring memorabilia of books and other reading material that show the roles Blacks have played related to each month’s movie topic. in the military. “Our goal is to promote The F-EDT encourages everyone to understanding through discussion and visit the monthly displays and enter discovery. We hope that we can get the drawings for free items such as an individual to spend the lunch hour movie tickets and food. ö watching a free movie and think. ‘My

The NCI-Frederick Poster 17 January 2003 Facilities Management, Engineering, and Planning

People, Progress & Plans competition, the foursome of Mitzi Guarino, Fred Guarino, Mark Fine, and Bob Socks ruled the day. The new fiscal year is one of Mitzi Guarino is Project Manager for the Vaccine Development Facility and change for much of SAIC-Frederick, was a member of the Partnership for Energy Performance (PEP) team which Inc., including the former Facilities won a 2002 Presidential Award for Leadership in Federal Energy Management. Maintenance and Engineering, now known as Facilities Management, Work Progress Highlights Engineering, and Planning (FMEP). FME completed a highly productive second half of FY 2002, as shown in the The new name reflects management following table. initiatives to transform FMEP from a reactive maintenance organization Activity Number Dollar Value into a proactive management and Major Renovations Completed 190 $6,000,000 planning directorate. With the FY2003 Trouble Calls Answered 4966 $3,800,00 marking the first anniversary of the customer-focused Directorate Special Requests Answered 1702 $468,000 Support Teams, FMEP employees are verifying with their customers that FMEP Engineering and Shops responded quickly to resolve a crisis with FMEP teams continue to meet the the permanent failure of the Building 560 autoclave. Within days, the shops research community’s needs and are removed the defective autoclave, while Engineering simultaneously completed seeking suggestions on ways to further placement and utility hook-up for a new unit, requiring both new steam and improve service. power lines. The new autoclave began operating August 29, one day before the date promised to NCI. People FMEP has expanded its workforce. Other major highlights for FMEP included: Bill Lonergan is the new Director. • The completion in two weeks of a new clean room for Lab 301, Building 472. Gemma Waltz and Craig Robillard • An offsite, vacant warehouse selected for the new Clinical Materials Program. joined project management teams, Completion is anticipated within the first quarter of calendar year 2004. while Jean-Paul Prentice and Kerry • Approval for the dismantling of Building 470, since additional sampling for Adams are here through a subcontract anthrax showed no evidence of any spores. with Capstone, Inc., for special assignments and to help in the 3 Month Look-Ahead Plan FMEP reorganization. Carol Shearer, Already this winter, snow removal has been necessary. FMEP crews clear previously busy demolishing bio- sidewalks, steps, and access to building doors, while Fort Detrick crews plow weapons facilities in the Soviet Union streets and parking lots in accordance with the Fort Detrick Snow Removal for Bechtel, leads the dismantlement Plan. For safety, and to support snow removal efforts, the NCI-Frederick follows of Building 470. Other new faces the lead of Fort Detrick for snow closings. See the insert elsewhere in this include Dan Rider, Manager of Project newsletter for information on snow closings. Controls, and his co-workers, Brad Beard and Ken Warrick. Another long- Construction Overview: the following diagram shows the schedule for current term loan from Bechtel is Bruce Ritter, planned major construction activities. Manager of Engineering. Wayne Appenzeller, a Senior Architect, and Betty Chang, a construction field The engineer, will help in the Building dismantling 470 dismantlement. Lydia Fine of Building and Christie Taylor joined us in the 470 will affect Administrative section. parking and With the changes in management and traffic flow the many new faces, the FMEP Morale around Buildings 427, 431, 469, and 470. As the detailed planning is completed, Committee held a golf tournament in personnel in those facilities will be alerted well before construction begins and November. After a morning of fierce provided alternative parking and access. ö

The NCI-Frederick Poster 18 January 2003 Poster- Script

Halloween Costume Contest

PALS Children Trick-or-Treating

The NCI-Frederick Poster 19 January 2003 Administrative Resource Center

Meet the NCI-Frederick Section, under Dr. Barbara Felber; and Computational Biology (LECB), Administrative Resource and the Human Retrovirus Section, a lab split between the Frederick and Center (ARC) Crew under Dr. George Pavlakis. Since the NIH campuses; the Laboratory October 2002, John also has been of Experimental Immunology (LEI); providing support to the world- and the Laboratory of Immunobiology The Administrative Resource Center renowned Laboratory of Molecular (LIB). From 1970 to 1978 Teri worked (ARC) is here to help; by taking care Immunoregulation (LMI) under the with the Metabolism Branch, NCI. In of administrative details for you, the leadership of Dr. Joost Oppenheim. 1978 the National Institute of Allergy “crew” hopes to make your quest in and Infectious Diseases (NIAID) finding the cures for cancer and AIDS Administrative Officers opened a BL-3 laboratory at the then- a little easier. Sondra “Sandy” Cavanaugh is FCRDC and Teri joined that group. If you have a question, please call the Administrative Officer for the She remained with NIAID until she them at 301-846- rejoined the NCI in 5402 (see contact 1990. information in the insert). Also, check Debra “Debbie” out The Poster at Dixon is a busy the NCI-Frederick woman. She is the Web site http: Administrative //web.ncifcrf.gov/ Officer to the Office ThePoster for of the Director (OD), further interesting Center for Cancer information about Research (CCR) the ARC crew. at Frederick; the Office of Scientific Operations, OD, Gretchen Jolles, NCI; Management NCI-Frederick ARC Operations and Manager, graduated Support Branch, OD, with a B.A. in NCI; three Section political science Chiefs, six Principal from American Investigators, and University, joining one Scholar within the National the BRL. Institutes of Health Front Row (L to R): Dee Crouse, Betsy Brown, Paula Itnyre. Second Row (L to (NIH) in 1977. R): Debbie Dixon, Judi Carter, Barbara Belldina, Gretchen Jolles. Third Row Lori Holliday, the Gretchen has worked (L to R): Deanna Dougherty, Lisa Virts, Teri Cecil, Carolynne Fitzpatrick, Jean Administrative Officer in administrative McCammon, Beth Cassell, Shannon Bell. Back Row (L to R): Tim Sakemiller, for the HIV DRP since positions in Valerie Turnquist, John Barone, Vanessa Guyton, Lori Holliday, Carrie Jennings. October 1998, has both extramural Not pictured: Sandy Cavanaugh and Tanya Sappington. been an Administrative and intramural Officer for seven research programs. Before joining Cancer and Developmental Biology years. Before that, she was a Personnel the ARC, she served as the Acting Laboratory (CDBL) and for the Management Specialist. Lori has been Associate Director for Administrative Macromolecular Crystallography with NCI for 12 years. Management. Laboratory (MCL). Sandy has worked at Fort Detrick for 19 years and has Carrie Jennings is the Administrative John Barone, Deputy ARC Manager, been with the ARC since October Officersupporting Dr. Kwak, Dr. also covers a small, although critically 1999. Wigginton, and Dr. Stanyon. She important segment of the Basic also handles the CCR’s space and Research Laboratory (BRL)—the Teri Cecil is the Administrative Officer renovations issues, takes care of the Human Retrovirus Pathogenesis for the Laboratory of Experimental summary of budget and costs for CCR,

The NCI-Frederick Poster 20 January, 2003 Administrative Resource Center and also handles the SAIC-Frederick, and Terry Copeland. She’s worked in Roscoe Stanyon’s group. In addition, Inc., funding issues. NCI laboratories since February 10, Dee assists Carrie with budget issues. 1991. Lisa joined the ARC in July Jean McCammon is the 1996 and became an Administrative Deanna Dougherty is the Administrative Officer for LGD under Officer in May 2000. Administrative Assistant for GRCBL the leadership of Dr. Stephen O’Brien, and MCGP. She joined the ARC in and LCC, under the leadership of Dr. Administrative Assistants December 1999 to support the entire Larry Keefer. Jean has been working Elizabeth “Betsy” Brown is the ARCbut soon began work with NCI- at the NIH for 35 years; 28 of which Administrative Assistant for both Lisa Frederick’s BRL, where she was the have been spent working at the NCI. Virts and Sandy Cavanaugh in the Administrative Technician for two MCL, CDBL, SBL, and BRL. Betsy years. Now she supports GRCBL and Timothy “Tim” Sakemiller is has worked for the ARC for seven MCGP. the Administrative Officer for the years. Molecular Targets Discovery Program Carolynne Fitzpatrick is the Office (MTDP) and the Laboratory of Judith “Judi” Carter is the Automation Assistant for the Frederick Medicinal Chemistry (LMC). He Administrative Assistant for LGD and ARC (a student position). She has started at NCI in August 1998 as a LCC. She started working at the NCI been working with NCI and the Presidential Management Intern. in 1987. government since June 2002. During the course of his internship, he completed rotations in the Melonie “Beth” Cassell is Vanessa Guyton is the Administrative ARCs for the Division of Cancer Administrative Assistant to both Assistant for both Tim Sakemiller Prevention (DCP), Division of Cancer John Barone and Debbie Dixon and Tanya Sappington in the RCGL, Epidemiology and Genetics, and the in the BRL and the LMI. Beth’s RPFL, LMC, and MTDP. She has been CCR, NCI-Frederick. thirtieth anniversary of employment working with the government for 11 at Fort Detrick will be in April 2003. years as of October 20, 2002. Tanya Sappington is the With the government since October Administrative Officer for the 1999, she previously worked for the Paula Itnyre is the Administrative Regulation of Protein Function Basic Research Contract Advanced Assistant for LECB, LEI and LIB. She Laboratory (RPFL) and the Regulation Bioscience Laboratories (ABL). started her government experience of Cell Growth Laboratory (RCGL). 15 years ago with LEI under Sue She began work with NCI-Bethesda Denise “Dee” Crouse is the Charbonneau and Dr. John Ortaldo in in March 1998 and came to NCI- Administrative Assistant for HIV-DRP, summer 1987; she’s been at the NCI Frederick in summer 1999. Dr. John Coffin’s group. She also since October 1989. ö assists Carrie Jennings with ETI, Dr. Valerie Turnquist is the Larry Kwak’s group; POB, Dr. Jon Administrative Officer for the Gene Wigginton’s group; and CMCC, Dr. Regulation and Chromosome Biology Laboratory (GRCBL) and the Mouse Cancer Genetics Program (MCGP). She began working for NIH in Bethesda, Maryland, in 1986 and joined NCI-Frederick in December 1999.

Lisa Virts is the Administrative Officer for the Structural Biophysics Laboratory (SBL) and BRL. The BRL Principal Investigators that Lisa supports include Drs. Sandra Ruscetti, Grace Yeh, Jim Phang, Kevin Lewis

The NCI-Frederick Poster 21 January 2003 Job Vacancies

Research and Training HIV Drug Resistance Program: Clinical Research Associate, Clinical Opportunities performing basic research on Monitoring Research Program: mechanisms of assembly and Provides expertise in NIAID clinical The following list is a summary only RNA recognition during retroviral research; oversees design, planning, of NCI-Frederick job vacancies as we replication with Dr. Alan Rein. and implementation; regulatory went to press. Please check individual [email protected]. guidelines in clinical trials; manage/ contractors’ Web sites for the most up- coordinate activities associated with to-date, detailed information and job Cancer and Developmental Biology clinical studies; open/close studies, requirements. Laboratory Group: focusing on manage clinical site; assist with CROs the role of FGF and BMP signaling and field CRAs, reporting of adverse pathway during mouse embryogenesis events, patient case report forms, Postdoctoral Job Vacancies with an emphasis on brain and limb randomization and drug dispensing, development, under the supervision of and accountability; preparation/ Dr. Mark Lewandoski. mlewandoski@ production of documents for FDA mail.ncifcrf.gov. submission, protocol reports and manuscripts. Cancer and Developmental Biology Requisition Number: KMB052972 NCI: Laboratory Group: axis determination and gastrulation in early mouse Clinical Research Associate II, Leukocyte Cell Biology Section, embryogenesis and gastrointestinal Clinical Monitoring Research Laboratory of Experimental tract development and cancer, Program: expertise in NIAID clinical Immunology: working with Dr. under the supervision of Dr. Terry research; sees that clinical trials adhere Stephen Anderson on the genetic Yamaguchi. [email protected]. to regulatory guidelines; open/close manipulation of the Ly49 gene cluster. studies; manage clinical site and [email protected]. For more listings in postdoctoral CROs and field CRAs; Assist with opportunities, please visit the Web design, planning, and implementation Viral Recombination Section, HIV site at http://www.training.nih.gov/ of clinical trials, project activities, Drug Resistance Program: studying postdoctoral/ reporting of adverse/serious adverse the retroviral replication using human events, preparation/production of immunodeficiency viruses and simple documents for FDA submission, retroviruses with Dr. Wei-Shau Hu. annual protocol reports, and [email protected]. manuscripts. Requisition Number: KMB054150 Vector Design and Replication Section, HIV Drug Resistance SAIC-Frederick, Inc. Clinical Research Associate III, Program: working with Dr. Stephen Persons interested in applying for Clinical Monitoring Research Hughes on the structure and function these or other positions should do Program: expertise in NIAID clinical of HIV-1 reverse transcriptase with so on the SAIC Web Site: http:// research; see that clinical trials an emphasis on understanding drug saic.ncifcrf.gov adhere to regulatory guidelines; resistance; and the development open/close studies; manage clinical and use of retroviral vectors. Animal Program Veterinarian, site and CROs and field CRAs; [email protected]. Laboratory Animal Sciences assist with design, planning, and Program: Provides veterinary implementation of clinical trials, Viral Mutation Section, HIV Drug medical diagnostic, surgical, and preparation/production of documents Resistance Program: defining with Dr. treatment services within the animal for FDA submission, annual protocol Vinay Pathak structural determinants facilities; compliance with AAALAC- reports, and manuscripts; manage/ of reverse transcriptase and other viral International guidelines; assists with coordinate clinical studies’ project proteins that affect the fidelity of viral training programs; consults with activities, reporting of adverse/serious replications. [email protected]. investigators. adverse events; design/produce patient Requisition Number: KMB050649 activities; case report forms; monitor Retrovirus Assembly Section, clinical trials, randomization and drug

The NCI-Frederick Poster 22 January 2003 Job Vacancies dispensing, and accountability; interact support estimates for mechanical assessments and coordinating studies with internal and external personnel systems and equipment. Designs on patients volunteering for HIV. to facilitate project timelines. Oversee include new and renovation work; Requisition Number: KMB053316 CRO activities, such as investigator meetings with customers; establish a meetings, study initiation, ongoing written definition of the customer’s Senior Nurse Practitioner, Vaccine monitoring, and close-out visits. requirements (SOW). Prepare Research Center, NIH-Bethesda: Assist in preparation/production of mechanical systems and equipment Perform interviews, health histories, documents for FDA submission, as procurement packages, review physical examinations and diagnostic well as annual protocol reports and proposals and prepare bid evaluations. tests; independently interpret data to manuscripts. Provide technical guidance to determine needs and problems and Requisition Number: KMB054153 customers, O&M, and design (A/E) plan appropriate therapeutic measures; and construction contractors. Review, collaborate with the clinical team; and Designer II, FMEP: Project and check, inspect and monitor work provide clinical supervision to lower Engineering–new and renovation performed by O&M, and outside A/Es level clinical staff. work; field surveys and meetings and construction contractors. Perform Requisition Number: JDC046573 with customers. Develop moderately validation to codes and standards and complex designs of engineering NIH requirements. systems, facility arrangements and Requisition Number: KMB052226 equipment; prepare detailed diagrams, CAD drawings; check others’ Physician’s Assistant, Vaccine drawings and designs for accuracy, Research Center, NIH-Bethesda: presentation, and compliance. Assign, Provide healthcare services, broad Wilson Information review, check, inspect and monitor range of diagnostic and therapeutic Services Corporation construction contractors’ work. services, primary and secondary (WISCO) Requisition Number: KMB052613 specialty care. Administrative/ managerial duties, clinical research. Check the WISCO Web site for Engineer III-Mechanical Engineer, Major responsibility for recruiting the latest job openings: http:/www- FMEP: Prepare Scope of Work study candidates for new vaccine [email protected]. (SOW), engineering designs, plans, strategies to prevent or mitigate calculations, specifications, and HIV infection, performing initial

The NCI-Frederick Poster 23 January 2003

The Poster Staff NIH Human Resources

Executive Editor Paul Miller NIH Human Resources services to address any unique needs Associate Editor Reorganization of individual [institutes]).” Ken Michaels Affects NCI The new, centralized OHR comprises Managing Editor six divisions: information systems, Maritta Grau [Editor’s note: The information below is based on an article by NIH writer Carla Garnett. The program effectiveness, employment Production Editor original article appeared in The NIH Record, services and benefits, workforce Kathy Green LIV(21):1, 4, 13.] management, employee relations Lead Designer and training, and human resources Tammy Schroyer Photography Editor “Partnership” and “corporate image” operations. Jonathan Summers are terms that we don’t often associate Nancy Bagley, a former NCI Marti Welch with government agencies. However, personnel employee and now a branch more and more, the NIH’s individual chief in the new Division of Human Contributing Editors institutes seek out partnerships with Resources Operations, pointed out other government agencies and with that one of “the biggest benefits of the Administrative Resource Center private industry, working together to reorganization will be the consistency Carrie Jennings achieve the NIH mission. To that end, in interpretation and application of HR Carolynne Fitzpatrick the Department of Health and Human policies.” Tanya Sappington Services has been encouraging its Continuing in the same vein, Chris Charles River Laboratories institutes to “partner” with each other Steyer, acting deputy director of Cliff Hubbard and to consolidate where possible the new OHR, said that “We hope Community Outreach Barbara Birnman so that they can better draw on each to be able to draw on our combined Data Management Services other’s strengths. strengths and knowledges more. Jim Racheff For the past 11 months, approxi- We also will begin to think more Environment, Health, and Safety mately 300 human resources (HR) corporately, as an NIH rather than just Program employees at NIH have focused as institutes. For example, recruiting Carol Ingraham-Tobias on a challenging goal from Health for the ‘NIH’ rather than ‘NCI’…will Facilities Management, Engineering and Human Services: create a market NIH…better.” and Planning central Office of Human Resources Ms Bagley added that the Dave Watson (OHR). This “major, fast-tracked reorganization “will bring NIH closer Kerry Adams reorganization” means that for to achieving its mission by further Frederick Employee Diversity Team National Cancer Institute employees, developing our corporate image, Scott Keimig whether at Frederick, Bethesda, or which will help us in recruiting and SAIC-Frederick, Inc. Dave Bufter elsewhere, procedures and routines retaining the best talent through our Science Today for all institutes will be handled outreach efforts. We will be able Steve Giardina consistently. to…share past successes and invent Wilson Information Services A tremendous effort has gone into new approaches to recruiting and Corporation the reorganization. After setting retaining the elite NIH scientific and Sue Wilson goals and holding focus groups, a administrative staff.” design team developed a model with In a final word, NIH Acting Director Published four times a year by three main focuses: “administrative for Human Resources, Fred Walker, Scientific Publications, Graphics support centers (to handle functions noted that a former supervisor had & Media for the National Cancer in which efficiency and process are once told him, “We derive tremendous Institute at Frederick, critical), centers of expertise (where benefit from our participation in a Frederick, MD 21702. specialized knowledge serves the great humanitarian mission. We must whole community in developing not lose sight of why we are here and http://web.ncifcrf.gov/ThePoster policies, resources, and best practices), the contributions that we all make to and business partnerships (consultative further the NIH mission.” ö

The National Cancer Institute at Frederick

Frederick, MD 21702-1201 FYI National Cancer Institute at Frederick Directory of ARC-supported Laboratories Post this list and use it as a resource to keep track of the laboratories that your NCI-Frederick ARC supports.

Acronym Official Title BRL Basic Research Laboratory CDBL Cancer and Developmental Biology Laboratory GRCBL Gene Regulation and Chromosome Biology Laboratory HIV-DRP HIV Drug Resistance Program LCC Laboratory of Comparative Carcinogenesis LGD Laboratory of Genomic Diversity LECB Laboratory of Experimental and Computational Biology LEI Laboratory of Experimental Immunology LIB Laboratory of Immunobiology LMC Laboratory of Medicinal Chemistry LMI Laboratory of Molecular Immunoregulation MCGP Mouse Cancer Genetics Program MCL Macromolecular Crystallography Laboratory MTDP Molecular Targets Discovery Program RCGL Regulation of Cell Growth Laboratory RPFL Regulation of Protein Function Laboratory SBL Structural Biophysics Laboratory

For any administrative assistance, refer to the NCI-Frederick staff listed below or call our main number at 301- 846-5402 and you will be directed to the proper administrative staff member. ö

Your ARC Crew: Here to Serve You! Carrie Jennings, ETI, POB, CMCC Beth Cassell (for John Barone and Debbie Gretchen Jolles, ARC Manager x1421; [email protected] Dixon) X1166; [email protected] Jean McCammon, LGD, LCC x1737; or [email protected] John Barone, Deputy ARC Manager x1415 [email protected] Dee Crouse (for HIV DRP, ETI, POB, x5404; [email protected] Tim Sakemiller, MTDP, LMC CMCC) x5162; [email protected] X5546 [email protected] Administrative Officers Tanya Sappington, RPFL, RCGL Deanna Dougherty (for GRCBL, MCGP) Sandy Cavanaugh, CDBL, MCL x1072; [email protected] x5199; [email protected] x1538; [email protected] Valerie Turnquist, GRCBL, MCGP Carolynne Fitzpatrick, Office Teri Cecil, LECB, CEI, LIB x5011; [email protected] Automation Assistant, ARC x5403 [email protected] Lisa Virts, SBL, BRL x5355; [email protected] Debbie Dixon, OD, CCR-Frederick; x5079; [email protected] Vanessa Guyton (for Tim Sakemiller and Office of Scientific Operations and Tanya Sappington) RCGL, RPFL, LMC, Management Operations and Support Administrative Assistants MTDP Branch, OD, NCI; BRL Betsy Brown (for Lisa Virts and Sandy x1539; [email protected] x1422; [email protected] Cavanaugh), MCL, CDBL, SBL, and BRL Paula Itnyre (for LECB, LEI, LIB) Lori Holliday, HIV Drug Resistance x1066; [email protected] x1779; [email protected] Program Judi Carter (for LGD, LCC) x1414; [email protected] x1413 [email protected] Weather Advisory

You peer out the bedroom window and see softly falling snow or the gleam of ice. Is the base closed? Here’s how to find out. Call the Fort Detrick Telenews (301-619-7611), listen to local radio/television stations, or contact the Frederick News Post Sound Source for information.

Closing or Delayed Opening Remember: When Fort Detrick is closed, NCI-Frederick is also closed; when Fort Detrick has a delayed opening, NCI- Frederick has a delayed opening. NCI-Frederick does not follow weather closing or delayed opening advisories for the NIH-Bethesda campus or Washington metropolitan area.

Early Dismissal For early dismissal, NCI-Frederick operates independently of Fort Detrick; therefore, your supervisor will notify you if NCI-Frederick closes during work hours.

Who Ya Gonna Call?

Telephone Recorded weather line 301-619-7611 Ft. Detrick toll free number 1-800-256-7621, *8, 37611#” TDD 301-619-2293 Sound Source weather line 301-695-2633, press 3801 (recorded line)

Internet (This will only be used if there is a change in operating hours.) Fort Detrick’s home page: http://detrick.army.mil/. Weather information pops up automatically.

Radio/TV

Frederick, MD Williamsport, MD Charles Town, WV WAFY FM/103.1 WCRH FM/90.5 WMRE AM/1550 WFMD AM/930 WXVA FM/98.3 WFRE FM/99.9 Chambersburg, PA WCHA AM/800 Arlington, VA Hagerstown, MD WIKZ FM/95.1 WWVZ FM/103.9 WARK 1490 WWZZ FM/104.1 WARX 106.9 Gettysburg, PA WJEJ AM/1240 WGET AM/1320 Washington, DC WWMD FM/101.5 WGTY FM/107.7 WTOP AM/1500 WHAG AM/1410 WMZQ 1390/98.7 WQCM FM/96.7 Mercersburg, PA WRQX FM/107.3 WHAG TV/Ch. 2 WSRT FM/104.7

Baltimore, MD Greencastle, PA WBAL AM/1090 WHGT AM/1380 WIYY FM/97.9 WAYZ FM/104.7 WPOC FM/93.1 WCAO AM/600 Martinsburg, WV B104.3 FM/104.3 WEPM AM/1340 WJZ TV/Ch. 13 WLTF 97.5

Thurmont, MD WTHU AM/1450 The National Cancer Institute at Frederick WEB EXTRAS

Wilson Information Services Corporation (WISCO)

WHO’S WHO AT WISCO— Alice Young CHI Health Quiz worked in such Which of the following would cause a Little Known Facts exotic places consumer to be cautious about a Web In our print issue (Vol. 1, issue 1) of as Hawaii and site promoting good health care? The Poster, we promised to tell you Okinawa, Japan, for more about the WISCO staff. Here a number of years. A) Information is provided by a are little known facts about the people government agency or educational institution. who help you in so many ways at the Our Systems Librarian, Steve Jones, Scientific Library. has always been interested in what B) The Web site will include a date goes on behind and it will be current. Darlene Clements was first part the computer of the Purchasing Department, and screen. These days, C) There will be good music and next assisted the when he is not lots of flashy advertisements. Publications staff, writing a software prior to coming to application, he D) Research citations will be the Library to handle continues to stay provided where appropriate. our photocopying. in touch with An animal lover, aquatic algae and Answer: C) Though good music and Darlene has several phytoplankton by way of kayaking, lots of flashy advertisements might make an interesting Web site, they pets, including a and probably has navigated every do not guarantee good health care turtle which lives in stream in the Western Maryland information. Look for the names the stream running through her back region, and then some. of organizations you recognize as yard. Woodie is so tame that he comes sponsors, such as the American Heart out whenever she calls him, to take a August 8, 1988, is Robin Meckley’s Association or Centers for Disease piece of tomato right from Darlene’s anniversary date. (If she hasn’t ever Control and Prevention. You want hand. bought a lottery ticket using the the newest information when looking number 8888, perhaps she should—it for answers, so beware Web sites last Ethel Armstrong left us temporarily might be a winner.) updated more than a few weeks ago. during 1987, but realized she missed She loves the movies the excitement of NCI-Frederick and has seen every too much and Harrison Ford film returned within that was ever only a few weeks. produced. On her vacations, She also she searches for has a something unique to penchant for Christmas and bring home to add to her collection of Mr. and Mrs. her doll collection. Santa Claus figures has grown Recently, she has begun to collect to over 300 pairs—that’s right, miniature shoes and purses as well. no singles are allowed under Don’t get in her way when there’s a her tree. sale on at Lord and Taylor! Environment, Health, and Safety Program

Is It a Cold or the Flu?

Symptoms Cold Flu

Fever rare in adults and older usually 102° F, but can go up children, but can be as high to 104° F and usually lasts 3 to as 102° F in infants and small 4 days children

Headache rare sudden onset and can be severe

Muscle aches mild usual, and often severe

Tiredness and weakness mild can last two or more weeks

Extreme exhaustion never sudden onset and can be severe

Runny nose often sometimes

Sneezing often sometimes

Sore throat often sometimes

Cough mild hacking cough usual, and can become severe

For more information from the CDC, go to:http://www.cdc.gov/nip/Flu/Public.htm or http://www.cdc.gov/nip/Flu/Cold-or-Flu.htm. ö

The NCI-Frederick Poster Extras 2 January 2003 Administrative Resource Center

Who’s Who in the with her Yorkshire terriers. August 2000 he has served as an ARC Crew— Administrative Officer in the Frederick Beth Cassell: ARC. Little Known Facts Outside of work, Beth hits the In his free time, he and his wife race track—NASCAR, that is. “My enjoy landscaping and furnishing husband and I are avid NASCAR fans the new home they recently built in In our print issue (Vol. 1, issue 1) of and attend many races each year,” Middletown Valley. The Sakemillers The Poster, we promised to tell you Beth says. both enjoy taking day trips to local more about the ARC staff. natural and historical sites. Sandy Cavanaugh: Gretchen Jolles: From 1983 to 1999, Sandy worked Vanessa Guyton: In addition to her workplace skills, for ABL. Outside of work, Sandy When Vanessa is not at work, she Gretchen is also a textile surface enjoys spending time with her three enjoys spending time with her husband designer and weaver. In her spare grandchildren. She also enjoys and two teenage sons. She also enjoys time, Gretchen enjoys volunteer work gardening and crafting. gardening, creating floral designs and for the Frederick Pony Club. crafting. Lisa Virts: John Barone: What keeps Lisa sane outside of Teri Cecil: Associated with NCI’s clinical and work is spending time with her three- Teri has a lot of responsibilities in the non-clinical basic research programs year-old niece, Hannah. “I guess it’s ARC. She manages the resources of both in the laboratory and more my escape from the adult world!” Lisa the LECB, LEI, and LIB (personnel, recently in administration, John has says. travel, budget, procurement, space, worked at NCI-Frederick nearly 30 contracts and IAG), negotiating years. Betsy Brown: grants with the Army, mentoring John enjoys outdoor activities When she’s not at work, Betsy enjoys administrative lab managers, and when he’s not at work. He is an avid playtime with her son, 11-month-old special projects. Even while doing photographer whose next planned trip Jeremy. “That’s all I have time for all this, Teri finds time to be involved with several friends will take him to a these days,” Betsy says. with the Frederick Diversity Team. privately owned ghost town in Lincoln To stay sane with all the work, Teri County, New Mexico. “And no, we Tanya Sappington: enjoys outside activities such as going are not looking for alien spacecraft Before working with NCI, Tanya to the beach. She also enjoys reading wreckage near Roswell,” John says. worked at the National Park Service. and walking her dogs, Montana and Tanya is not only an Administrative Taylor. A new addition to her family, Debbie Dixon: Officer but also the NCI-Frederick her grand-puppy, Jeter, keeps her After obtaining her A.A. in Business ARC Web site coordinator, NIHITS hopping, too. One of Teri’s favorite Administration from Frederick coordinator and this newsletter’s hobbies is to plan social events for Community College, Debbie began administrative co-chair. her family, friends and neighbors— working for the NCI in May 1984. When Tanya is not working, she anything from the Super Bowl to She says, “It’s hard to believe that I enjoys reading, seeing movies, holidays to special occasions. will soon have 19 years of service! It’s traveling, completing crafts, and actually been fun at times!” spending time with family, friends, Paula Itnyre: In addition to her NCI and her many pets. Tanya has two Paula previously worked with the responsibilities, Debbie is president dogs, two cats, a parrot, and saltwater National Park Service and then the of the East Frederick Little League, fish. Department of Energy. a volunteer with Frederick’s Babe She has remained in the same office Ruth Baseball League, for which her Tim Sakemiller: throughout various reconstructions and two sons play, and also keeps track “I am particularly grateful to Jackie consolidations, providing support for of four dogs and a cat. When she can Havens and Mary Lou Carter for the Laboratory of Genomic Diversity find time for herself, she enjoys going giving me my start in DCP and for (LGD), the Laboratory of Comparative to baseball games, skiing, antique their mentoring,” Tim says. Since Carcinogenesis (LCC), the HIV Drug shopping, doing crafts, and playing the completion of his internship in Resistance Program (HIV-DRP),

The NCI-Frederick Poster Extras 3 January, 2003 Administrative Resource Center

RCGL, and CDBL. Jean McCammon: Carrie Jennings: Paula enjoys seasonal interests, such In her free time, Jean loves spending Carrie started at NIH in 1979 and has as skiing and baseball, to remain sane time with family (and she loves being been working at NCI-Frederick since in the workplace. She also enjoys a grandma). She also enjoys skiing. 1983, a total of 23 years. family time. When she’s not hard at work dealing Judi Carter: with budget issues, Carrie enjoys Lori Holliday: In her free time Judi does stained family time with her two (yes, two) Before she worked here, Lori was glass crafts—to remain sane, she says. sets of twins. employed with the National Institute To see one of her original creations, of Mental Health. stop by the ARC office and look above Carolynne Fitzpatrick: Congratulations to Lori for recently the front desk. Carolynne is a commuting senior graduating summa cum laude from the at Hood College, double-majoring University of Maryland with a BS in Valerie Turnquist: in Communications (Journalism Behavioral and Social Sciences. When she’s not at work, Valerie concentration) and Psychology and a In her spare time, Lori enjoys reading says she loves spending time with minor in Writing. When she graduates and gardening. her wonderful husband, her (almost) in May 2003, she hopes to continue teenage daughter and her one-year-old working in her field of journalism. Dee Crouse: triplets. “My mind stays sharp just Carolynne spends much of her free Dee worked with the former ABL for trying to stay one step ahead of them,” time doing what she loves most— 19 years and has been working with Valerie says. writing. She does freelance articles NCI for the past three years. with area magazines and newspapers Many of you may recognize Dee Deanna Dougherty: and also submits short stories and because she is active in the ERC Outside work, Deanna likes to spend poetry for publications and contests. (Employee Recreation Committee) at time with family and friends. She also She’s obsessed with Fiestaware© NCI-Frederick. You may have stopped enjoys going to the gym and horseback and collects it in droves, much to her by her office for tickets to an event or riding. parents’ chagrin. ö an amusement park. Outside of work, Dee enjoys doing things with her family, getting together with family and friends. And she says she goes to amusement parks quite often. She’s also the ARC’s (and quite possibly NCI’s) biggest Elvis Presley fan.

The NCI-Frederick Poster Extras 4 January 2003