HSTA 2020 Circulatory System

Total Page：16

File Type：pdf, Size：1020Kb

Respiratory System Respiratory System Anatomy Nasal cavity Oral cavity Pharynx Larynx Trachea Left main (primary) Right main bronchus (primary) bronchus Right lung Left lung Inhalation & Exhalation • A key component of inhalation (breathing in) is taking up oxygen into the body. • A key component of exhalation (breathing out) is releasing carbon dioxide out of the body. • Note that the air in the atmosphere has both oxygen and carbon dioxide (as well as nitrogen and other gasses). When one inhales, we take in a mixture of all of these gasses found in the atmosphere into the lungs. When we exhale, we exhale a mixture of all of these gasses. • The main function for breathing is to take in oxygen and remove excess carbon dioxide from our bodies. • Oxygen (O2) is needed by every cell in the body (brain, heart, muscles, etc.) to generate energy. • Carbon dioxide (CO2) is a biproduct of producing energy. Having excess carbon dioxide can be toxic to the body, therefore, it is necessary to remove excess carbon dioxide from the body. Oxygen Flow • Oxygen enters the body through the nasal cavity or oral cavity during inhalation (breathing in). Oxygen then passes through the pharynx (posterior to nasal and oral cavities), down the larynx, and into the trachea. • The trachea branches into the left Nasal cavity Oral cavity and right bronchi Pharynx (singular bronchus) Larynx leading oxygen to Trachea Left main the lungs. (primary) Right main bronchus (primary) bronchus Right lung Left lung Oxygen Flow Trachea Bronchi • In the lungs, the left (branch smaller and right bronchi and smaller) branch into smaller and smaller bronchi (see image), like branches on a tree. • Oxygen flows through these smaller and smaller branches. Oxygen Flow • The smallest of these branches are called respiratory bronchioles, and these lead to many alveoli (alveolus singular). • The alveolus is a round structure that is part of the lungs, and is where gas exchange occurs. Alveolus = 1 Alveoli = more than 1 Alveolar sac = bundle/bunch of Alveoli Alveoli Alveolar duct Respiratory Alveolar duct bronchioles Terminal Alveolar bronchiole sac Oxygen Flow • The alveolus is where gas exchange occurs between the lungs (alveolus) and blood. • Alveoli are covered in capillaries to allow gas exchange. • Reminder: capillaries are the smallest of blood vessels. • At the alveolus, oxygen passes from the alveolus through the respiratory membrane and into the blood. Respiratory bronchiole O2 Alveolus CO2 Capillary Capillaries Alveolus Respiratory Membrane Carbon Dioxide Flow • As oxygen passes from the alveolus and into the blood, carbon dioxide exits the blood by passing from the blood (in capillaries), though the respiratory membrane, and into the alveolus. • Carbon dioxide then passes from the alveolus to respiratory bronchioles. Respiratory bronchiole O2 CO2 Alveolus Capillary Capillaries Alveolus Respiratory Membrane Carbon Dioxide Flow • Carbon dioxide continues to pass through the bronchi in the lungs, to the trachea, into the larynx, then pharynx, until it reaches the oral or nasal cavity and then is released into the atmosphere when exhaling (breathing out). Trachea Bronchi Nasal cavity Oral cavity Pharynx Larynx Trachea Left main (primary) Right main bronchus (primary) bronchus Left lung Right lung.

Copy Link

Recommended publications

Inhalation Devices: Various Forms of Administration for Therapeutic Optimization
vv ISSN: 2640-8082 DOI: https://dx.doi.org/10.17352/oja CLINICAL GROUP Renata Cristina de Angelo Calsaverini Leal* Review Article Santa Fé do Sul Foundation of Education and Culture, Brazil Inhalation Devices: Various forms Dates: Received: 31 May, 2017; Accepted: 26 June, of administration for Therapeutic 2017; Published: 27 June, 2017 *Corresponding author: Renata Cristina de Angelo Optimization Calsaverini Leal, Santa Fé do Sul Foundation of Education and Culture, Brazil, Tel: 55 (17) 3272-2769, E-mail: Keywords: Inhalation; Aerosol; Nebulizer Summary https://www.peertechz.com Introduction: Aerosol therapy consists of spraying liquid particles suspended for therapeutic purposes in the respiratory tract. With direct absorption and deposition at the lung level, avoiding side effects and presenting fast response time. Several factors inﬂ uence the drug action, such as size, particle movement, ventilatory ﬂ ow, pulmonary expansion, anatomy, respiratory mechanics and the nebulizer and patient interface. The therapeutic optimization depends on the type of nebulizer differentiating itself by the physical principle that generates the mist. Objectives: Check advantages and disadvantages of different inhalation devices. Methodology. This is a review of the PubMed database using descriptors: ultrasonic and jet nebulizer, aerosol deposition in the lung, metered dose inhaler and dry, inhaler therapy. Results: Different devices are mentioned in the literature: pneumatic and ultrasonic nebulizers (administering solutions), metered pressurized inhalers - pMDI used with or without expander chamber (administering suspensions) and dry powder inhalers - DPI (administering powder). Discussion and Conclusion: The US has advantages: quiet, does not require coordinating abilities, without propellant gases and quick nebulization with small amount of solution. Disadvantages: change in the active principle of thermosensitive drugs, deposition in the oropharynx and VAI of 2% of inhaled particles.
[Show full text]
Respiratory System
Respiratory system Department of Histology and Embryology of Jilin university ----Jiang Wenhua 1. General description z the nose, the pharynx, the larynx, the trachea, bronchus, lung zFunction: inspiring oxygen, expiring carbon dioxide The lung synthesises many materials 2.Trachea and bronchi General structure mucosa submucosa adventitia The trachea is a thin-walled tube about 11centimeters long and 2 centimeters in diameter, with a somewhat flattened posterior shape. The wall of the trachea is composed of three layers: mucosa, submucosa, and adventitia 2.1 mucosa 2.1.1 pseudostratified ciliated columnar epithelium 2.1.1.1 ciliated columnar cells These cells are columnar in shape with a centrally –located oval –shaped nucleus, on the free surface of the cells are microvilli and cilia, which regularly sweep toward the pharynx to remove inspired dust particles 2.1.1.2 brush cells These cells are columnar in shape with a round or oval –shaped nucleus located in the basal portion. on the free surface the microvilli are arranged into the shape of a brush. These cells are considered to be a type of under-developed ciliated columnar cell Schematic drawing of the trachea mucosa Scanning electron micrographs of the surface of mucosa Schematic drawing of the trachea mucosa 2.1.1.3 goblet cells secrete mucus to lubricate and protect the epithelium Schematic drawing of the trachea mucosa 2.1.1.4 basal cells These cells are cone –shaped and situated in the deep layer of the epithelium. Their apices are not exposed to the lumen, and their nuclei are round in shape, such cells constitute a variety of undifferentiated cells 2.1.1.5 small granular cells These cells are a kind of endocrine cells .
[Show full text]
1. Launch the View! • Launch Human Anatomy Atlas. • Navigate to Quizzes/Lab Activities, Find the Respiratory Lab Section
Name: __________________________________________________________ Date: ______________________________ Activity 1: Respiratory System Lab 1. Launch the view! • Launch Human Anatomy Atlas. • Navigate to Quizzes/Lab Activities, find the Respiratory Lab section. • Launch Augmented Reality mode and scan the image below. • Don’t have AR? Select view 1. Respiratory System. 2. Fill in the blanks. • Find the structures listed in the word bank. • Read the definitions, then fill in the blank with the correct respiratory system structure from the word bank. © Argosy Publishing, Inc., 2007-2018. All Rights Reserved. 1/2 Name: __________________________________________________________ Date: ______________________________ Word bank: • Alveoli • Nasopharynx • Bronchi • Oropharynx • Laryngopharynx • Primary bronchi • Lungs • Trachea • Nasal cavity The ______________________________ is composed of the chambers of the internal nose that function as a part of the upper respiratory system. The ______________________________ is the most posterior part of the pharynx. It is shared by the respiratory system and the digestive system. The upper respiratory and upper digestive tracts diverge right after this structure. The front of this structure merges with the triangular entrance of the larynx. The ______________________________ conveys air between the upper and lower respiratory structures. The ______________________________ is a portion of the pharynx that begins at the rear of the nasal cavity and functions as an airway in the upper respiratory system. Its cavity always stays open, unlike the other parts of the pharynx. The ______________________________ are two organs that are responsible for gas exchange. The ______________________________ are the major airways of the lower respiratory system. The ______________________________ are the main sites of gas exchange, where oxygen is brought into the bloodstream and carbon dioxide is removed.
[Show full text]
Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-Tailed Opossum (Monodelphis Domestica) and North American Opossum (Didelphis Virginiana)
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 12-2001 Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana) Lee Anne Cope University of Tennessee - Knoxville Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Part of the Animal Sciences Commons Recommended Citation Cope, Lee Anne, "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana). " PhD diss., University of Tennessee, 2001. https://trace.tennessee.edu/utk_graddiss/2046 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Lee Anne Cope entitled "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana)." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Animal Science. Robert W. Henry, Major Professor We have read this dissertation and recommend its acceptance: Dr. R.B. Reed, Dr. C. Mendis-Handagama, Dr. J. Schumacher, Dr. S.E. Orosz Accepted for the Council: Carolyn R.
[Show full text]
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists.
[Show full text]
Nasal Cavity Trachea Right Main (Primary) Bronchus Left Main (Primary) Bronchus Nostril Oral Cavity Pharynx Larynx Right Lung
Nasal cavity Oral cavity Nostril Pharynx Larynx Trachea Left main Right main (primary) (primary) bronchus bronchus Left lung Right lung Diaphragm © 2018 Pearson Education, Inc. 1 Cribriform plate of ethmoid bone Sphenoidal sinus Frontal sinus Posterior nasal aperture Nasal cavity • Nasal conchae (superior, Nasopharynx middle, and inferior) • Pharyngeal tonsil • Nasal meatuses (superior, middle, and inferior) • Opening of pharyngotympanic • Nasal vestibule tube • Nostril • Uvula Hard palate Oropharynx • Palatine tonsil Soft palate • Lingual tonsil Tongue Laryngopharynx Hyoid bone Larynx Esophagus • Epiglottis • Thyroid cartilage Trachea • Vocal fold • Cricoid cartilage (b) Detailed anatomy of the upper respiratory tract © 2018 Pearson Education, Inc. 2 Pharynx • Nasopharynx • Oropharynx • Laryngopharynx (a) Regions of the pharynx © 2018 Pearson Education, Inc. 3 Posterior Mucosa Esophagus Submucosa Trachealis Lumen of Seromucous muscle trachea gland in submucosa Hyaline cartilage Adventitia (a) Anterior © 2018 Pearson Education, Inc. 4 Intercostal muscle Rib Parietal pleura Lung Pleural cavity Trachea Visceral pleura Thymus Apex of lung Left superior lobe Right superior lobe Oblique Horizontal fissure fissure Right middle lobe Left inferior lobe Oblique fissure Right inferior lobe Heart (in pericardial cavity of mediastinum) Diaphragm Base of lung (a) Anterior view. The lungs flank mediastinal structures laterally. © 2018 Pearson Education, Inc. 5 Posterior Vertebra Esophagus (in posterior mediastinum) Root of lung at hilum Right lung • Left main bronchus Parietal pleura • Left pulmonary artery • Left pulmonary vein Visceral pleura Pleural cavity Left lung Thoracic wall Pulmonary trunk Pericardial membranes Heart (in mediastinum) Sternum Anterior mediastinum Anterior (b) Transverse section through the thorax, viewed from above © 2018 Pearson Education, Inc. 6 Alveolar duct Alveoli Respiratory bronchioles Alveolar duct Terminal bronchiole Alveolar sac (a) Diagrammatic view of respiratory bronchioles, alveolar ducts, and alveoli © 2018 Pearson Education, Inc.
[Show full text]
GLOSSARY of MEDICAL and ANATOMICAL TERMS
GLOSSARY of MEDICAL and ANATOMICAL TERMS Abbreviations: • A. Arabic • abb. = abbreviation • c. circa = about • F. French • adj. adjective • G. Greek • Ge. German • cf. compare • L. Latin • dim. = diminutive • OF. Old French • ( ) plural form in brackets A-band abb. of anisotropic band G. anisos = unequal + tropos = turning; meaning having not equal properties in every direction; transverse bands in living skeletal muscle which rotate the plane of polarised light, cf. I-band. Abbé, Ernst. 1840-1905. German physicist; mathematical analysis of optics as a basis for constructing better microscopes; devised oil immersion lens; Abbé condenser. absorption L. absorbere = to suck up. acervulus L. = sand, gritty; brain sand (cf. psammoma body). acetylcholine an ester of choline found in many tissue, synapses & neuromuscular junctions, where it is a neural transmitter. acetylcholinesterase enzyme at motor end-plate responsible for rapid destruction of acetylcholine, a neurotransmitter. acidophilic adj. L. acidus = sour + G. philein = to love; affinity for an acidic dye, such as eosin staining cytoplasmic proteins. acinus (-i) L. = a juicy berry, a grape; applied to small, rounded terminal secretory units of compound exocrine glands that have a small lumen (adj. acinar). acrosome G. akron = extremity + soma = body; head of spermatozoon. actin polymer protein filament found in the intracellular cytoskeleton, particularly in the thin (I-) bands of striated muscle. adenohypophysis G. ade = an acorn + hypophyses = an undergrowth; anterior lobe of hypophysis (cf. pituitary). adenoid G. " + -oeides = in form of; in the form of a gland, glandular; the pharyngeal tonsil. adipocyte L. adeps = fat (of an animal) + G. kytos = a container; cells responsible for storage and metabolism of lipids, found in white fat and brown fat.
[Show full text]
Nomina Histologica Veterinaria, First Edition
NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria.
[Show full text]
Normal Development of the Lung and Premature Birth
Paediatric Respiratory Reviews 11 (2010) 135–142 Contents lists available at ScienceDirect Paediatric Respiratory Reviews Mini-Symposium: Chronic Neonatal Lung Disease CNLD/BPD Normal Development of the Lung and Premature Birth Lucia J. Smith 1,2, Karen O. McKay 1,2, Peter P. van Asperen 1,2, Hiran Selvadurai 1,2, Dominic A. Fitzgerald 1,2,* 1 Department of Respiratory Medicine, The Children’s Hospital at Westmead, Locked Bag 4001 Westmead NSW Australia 2145 2 Discipline of Paediatrics and Child Health, Faculty of Medicine, The University of Sydney, Sydney NSW Australia ARTICLE INFO SUMMARY Keywords: The following review focuses on the normal development of the lung from conception to birth. The alveoli deﬁned periods of lung development–Embryonic, Pseudoglandular, Canalicular, Saccular and Alveolar– bronchopulmonary dysplasia will be explored in detail in relation to gestational age. Cellular differentiation, formation of the lung development conducting airways and respiratory zone and development of the alveoli will be reviewed. Pulmonary premature birth vascular development will also be examined within these periods to relate the formation of the blood-air barrier to the lungs for their essential function of gas exchange after birth. The development of the surfactant and cortisol systems will also be discussed as these need to be mature before the lungs are able to take on their role of respiration following birth. It is clear that premature birth interrupts normal lung development so the effect of preterm birth on lung development will be examined and the respiratory consequences of very preterm birth will be brieﬂy explored. Crown Copyright ß 2009 Elsevier Ltd.
[Show full text]
2.05 Remember the Structures of the Respiratory System 2.05 Remember the Structures of the Respiratory System
2.05 Remember the structures of the respiratory system 2.05 Remember the structures of the respiratory system Essential question What are the structures of the respiratory system? 2.05 Remember the structures of the respiratory system 2 Structures of the respiratory system Upper Respiratory System Nose Sinuses Pharynx Epiglottis Larynx Lower Respiratory System Trachea Lungs 2.05 Remember the structures of the respiratory system 3 Structures of the Upper Respiratory System Nose Nasal cavity – space behind the nose Vestibular region Olfactory region Respiratory region Nasal septum – cartilage that divides the nose into right and left sides Turbinates – scroll-like bones in the respiratory region Cilia – nose hairs 2.05 Remember the structures of the respiratory system 4 Structures of the Upper Respiratory System Sinuses - Cavities in the skull. Ducts connect sinuses to the nasal cavity Lined with mucous membrane to warm and moisten the air Provide resonance to the voice 2.05 Remember the structures of the respiratory system 5 Structures of the Upper Respiratory System Pharynx Throat Nasopharynx Oropharynx Laryngopharynx About 5” long 2.05 Remember the structures of the respiratory system 6 Structures of the Upper Respiratory System Epiglottis A flap or lid that closes over the opening to the larynx when food is swallowed 2.05 Remember the structures of the respiratory system 7 Structures of the Upper Respiratory System Larynx Voice Box Triangular chamber below pharynx Within the larynx are vocal cords, the glottis Also called the Adam’s Apple 2.05 Remember the structures of the respiratory system 8 Structures of the Lower Respiratory System Trachea Windpipe Approximately 4 ½” long The walls are composed of alternate bands of membrane and C-shaped rings of hyaline cartilage.
[Show full text]
25. Anatomy of the Respiratory System Answers to Pre-Lab Assignments Pre-Lab Activity 1: 1
25. Anatomy of the Respiratory System Answers to Pre-Lab Assignments Pre-Lab Activity 1: 1. a. left lung b. right lung c. diaphragm d. nasal cavity e. pharynx f. larynx g. upper respiratory tract h. trachea i. bronchi j. bronchiole k. alveolus l. lower respiratory tract 2. a. 4 b. 7 c. 9 d. 1 e. 6 f. 8 g. 2 h. 3 i. 5 Pre-Lab Activity 2: 1. a. 5 b. 2 c. 1 d. 4 e. 3 2. cells are thin and flat for efficient gas exchange 3. cartilaginous rings prevent collapse Pre-Lab Activity 3: 1. larynx, trachea, lungs, heart, and parts of major blood vessels 2. air hose and compressed air Answers to Activity Questions Activity 1 Making Connections: Organs of the Respiratory System Respiratory Structure Function(s) Connections to Things I Have Already Learned Nasal cavity Warms, mois- Nasal conchae with meatuses cause air • Anterior nares tens, and fil- turbulence to warm and moisten air more • Nasal septum ters incoming efficiently; olfactory nerve fibers of the • Nasal conchae air. olfactory nerve (CN I) pass through the • Posterior nares olfactory foramina of the cribriform plate • Hard palate of the ethmoid bone, carrying afferent • Soft palate messages to the thalamus and mammil- lary bodies (olfactory relay stations). Paranasal sinuses Reduce Maxillary bone = facial bone • Maxillary weight of skull Sphenoid, ethmoid, and frontal bones = • Sphenoid and add reso- cranial bones • Ethmoid nance to Frontal voice. Pharynx Common pas- Tonsils (palatine, pharyngeal, lingual) are • Nasopharynx sageway for associated with the pharynx. • Oropharynx food, fluid, • Laryngopharynx and air.
[Show full text]
Nerve Growth Factor Is Released by IL-1B and Induces Hyperresponsiveness of the Human Isolated Bronchus
Eur Respir J 2005; 26: 15–20 DOI: 10.1183/09031936.05.00047804 CopyrightßERS Journals Ltd 2005 Nerve growth factor is released by IL-1b and induces hyperresponsiveness of the human isolated bronchus N. Frossard*, E. Naline#, C. Olgart Ho¨glund*, O. Georges" and C. Advenier# ABSTRACT: Nerve growth factor (NGF) is a neurotrophic factor essential for the development and AFFILIATIONS survival of neurons, and is also an important mediator of inflammation. It is released by airway *EA 3771, Inflammation and environment in asthma, Universite´ cells stimulated by interleukin (IL)-1b. As IL-1b induces airway hyperresponsiveness (AHR) to the Louis Pasteur, Strasbourg, and 9 11 tachykinin NK-1 receptor agonist [Sar ,Met(O2) ]-substance P in human isolated bronchi, the aim #UPRES EA220, Universite´ de of this study was to determine whether IL-1b was able to induce NGF release from isolated Versailles and UFR Biome´dicale des Saints-Pe`res, and bronchi, and whether NGF might participate into IL-1b-induced AHR. " -1 Laboratoire d’anatomo-pathologie IL-1b (10 ng?mL ;21˚C; 15 h) increased the release of NGF from human isolated bronchi in vitro, Guigui-Georges, Paris, France. 9 11 and, in organ bath studies, the response of human bronchi to [Sar ,Met(O2) ]-substance P (0.1 mm). A significant correlation was found between these responses. AHR induced by IL-1b was CORRESPONDENCE abolished by a blocking anti-human NGF antibody. Finally, NGF (1 ng?mL-1;37˚C; 0.5 h) by itself N. Frossard 9 11 EA 3771 induced a significant increase in [Sar ,Met(O2) ]-substance P responsiveness.
[Show full text]