EIF4EBP1 Polyclonal Antibody Family of Translation Repressor Proteins

EIF4EBP1 polyclonal antibody family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation Catalog Number: PAB18142 factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal Regulatory Status: For research use only (RUO) subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and Product Description: Rabbit polyclonal antibody raised represses translation. This protein is phosphorylated in against synthetic peptide of EIF4EBP1. response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E Immunogen: A synthetic peptide corresponding to and activation of mRNA translation. [provided by human EIF4EBP1. RefSeq]

Host: Rabbit References: 1. Phosphorylation of 4E-BP1 is mediated by the Reactivity: Human,Mouse,Rat p38/MSK1 pathway in response to UVB irradiation. Liu Applications: ELISA, IHC-P, WB-Ce G, Zhang Y, Bode AM, Ma WY, Dong Z. J Biol Chem. (See our web site product page for detailed applications 2002 Mar 15;277(11):8810-6. Epub 2002 Jan 2. information) 2. Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. Jiang YP, Ballou LM, Lin RZ. J Protocols: See our web site at Biol Chem. 2001 Apr 6;276(14):10943-51. Epub 2001 http://www.abnova.com/support/protocols.asp or product Jan 25. page for detailed protocols

Specificity: This antibody is specific to EIF4EBP1.

Form: Liquid

Purification: Affinity purification

Concentration: 1 mg/mL

Recommend Usage: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:5000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

Storage Instruction: Store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 1978

Gene Symbol: EIF4EBP1

Gene Alias: 4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I

Gene Summary: This gene encodes one member of a

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