Curriculum Vitae: Thomas E
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Lipids Posterpub2000.Pub
58th Annual Meeting of the Society of General Physiologists Organized by Don Hilgemann, Scott Emr & Pietro De Camilli September 8-12, 2004 Marine Biological Laboratory Woods Hole, Massachusetts Feature Lectures Lew Cantley - Harvard University Scott Emr - HHMI, UC - San Diego Lipid sensors, domains & energies Stuart McLaughlin - SUNY, Stony Brook Evan Evans - UBC, Vancouver Lipid Tobias Meyer - Stanford University Jim Hurley - NIDDK-NIH Michael Overduin - University of Colorado i Signaling Membrane trafficking n Pietro De Camilli - HHMI, Yale University Nils Brose - Max Planck, Göttingen Physiology Gisou van der Goot - Université de Geneve Sergio Grinstein - Hospital for Sick Children sponsored in part Toronto by a major grant from Pfizer, Inc. Cytoskeleton & motility Ion channels & transporters Mike Sheetz - Columbia University Bertil Hille - University of Washington Helen Yin - UTSW, Dallas Don Hilgemann - UTSW, Dallas Dieter Klopfenstein Diomedes Logothetis - Mount Sinai UC - San Francisco Roger Hardie - University of Cambridge Silvia Corvera UMass Worcester David Julius - UC - San Francisco Peter Devreotes HHMI, Johns Hopkins Feature Lecture Michael Brown - UTSW, Dallas New horizons in lipid-protein interactions Steve White - UC, Irvine Gunnar von Heijne - Stockholm University Roderick MacKinnon - HHMI, Rockefeller Feature Lecture Jack Dixon - University of California, San Diego A number of symposium awards are available to postdoctoral fel- Abstract deadline -April 15, 2004 lows and students to help defray costs of attending the 2004 SGP www.sgpweb.org symposium. 508-540-6719 Formal sessions begin at 7 p.m. on September 8 and end at 12:30 p.m. on September 11. The afternoon and evening of September 11 Society of General Physiologists, P.O. Box 257, Woods Hole, MA 02543 are free for continued discussions with poster presenters and T: 508-540-6719, F: 508-540-0155, E: [email protected], W: www.sgpweb.org meeting attendees as well as sight-seeing. -
Scott Feller Full Curriculum Vitae Dr. Scott E. Feller President and Lloyd
Scott Feller Full Curriculum Vitae Dr. Scott E. Feller President and Lloyd B. Howell Professor of Chemistry Wabash College 301 W. Wabash Ave Crawfordsville IN 47933 office (765) 361-6224 e-mail [email protected] EDUCATION Ph.D., Physical Chemistry, University of California, Davis. Dec 1993. Dissertation: Application of the Hypernetted Chain Approximation to the Electrical Double Layer. Advisor: Dr. Donald A. McQuarrie. B.A., Major: Chemistry, Minor: Mathematics, Willamette University, May 1989. ADMINISTRATIVE EXPERIENCE President of the College, Wabash College, 2020-present Dean of the College (Chief Academic Officer), Wabash College, 2014-2020. Chair, Division of Natural Sciences & Mathematics, Wabash College, 2009-2014. Chair, Department of Chemistry, Wabash College, 2006-2009. TEACHING EXPERIENCE Professor of Chemistry, Wabash College, 2009-present. Associate Professor of Chemistry, Wabash College, 2003-2009. Assistant Professor of Chemistry, Wabash College, 1998-2003 Visiting Assistant Professor, Whitman College, 1996-1998 Teaching Assistant, University of California at Davis, 1989-1993 RESEARCH EXPERIENCE Visiting Scientist, IBM Research – Watson Laboratory, Yorktown Heights NY, 6/04-6/07. Principal Investigator, Department of Chemistry, Wabash College, 7/98-present. Principal Investigator, Department of Chemistry, Whitman College, 9/96-7/98. 1 Staff Fellow, Center for Biologics Evaluation & Research (FDA laboratory at the National Institutes of Health), 2/94-8/96. Supervisor: Dr Richard Pastor, Biophysics Laboratory. Visiting Researcher, University of Leipzig, May 1996. Supervisor: Dr. Frank Volke, Department of Physics. Graduate Study, UCDavis, 1/90-12/93. Supervisor: Dr. D.A. McQuarrie, Department of Chemistry. Visiting Researcher, Universidad Autonoma Metropolitina-Iztapalapa (Mexico City), June-July 1992. Supervisor: Dr. Marcelo Lozada-Cassou, Department of Physics. -
1. Introduction 1.1. A. Basic Biology of Membranes and Membrane Fusion. Biological Membranes Consist of Lipids and Proteins
1. Introduction 1.1. A. Basic biology of membranes and membrane fusion. Biological membranes consist of lipids and proteins, with the lipids self-organized into sheets and the proteins embedded into or bound to the sheets. The lipid sheets are arranged as a “bilayer,” two lipid monolayers with lipid acyl chains (i.e., hydrophobic tails) directly abutted against each other and sequestered from the aqueous solutions bathing the two sides of the membrane by the polar headgroups of the lipid molecules. The lipid bilayer membrane appeared early in evolution (1), and provides the barrier between interiors and exteriors of all eukaryotic (nucleus-containing) cells and their organelles. The architectural organization of the lipid bilayer is critical to life, and the functioning of proteins embedded in membranes is intrinsically connected to the bilayer structure in which they reside. The lipid bilayer also functions as an insulator for all activity within the body: the generation and propagation of action potentials in neurons and heart cells (2), and the voltage across mitochondrial membranes (i.e., batteries) that drives the production of ATP, the currency of cellular energy (3). Bilayer lipids provide extracellular (4) and intracellular molecules (5) that integrate the functioning of cells within body tissues. These and a host of other cellular functions rely on the integrity of the lipid bilayer structure (6). The bilayer membrane is a complex, dynamic structure. Its lipids are asymmetric in all directions, are in rapid motion, rotating, for example, 107 times/sec (7), and both the mass and electron density profiles of each lipid are heterogeneous along its length (1.5 – 2 nm) (8). -
Bertil Hille
Bertil Hille BORN: New Haven, Connecticut October 10, 1940 EDUCATION: Yale University, B.S. (1962) The Rockefeller University, Ph.D. (1967) APPOINTMENTS: Fellow, Cambridge University, Physiological Laboratory, Cambridge, England (1967–1968) Assistant Professor, University of Washington, Department of Physiology and Biophysics (1968–1971); Associate Professor (1971–1974); Professor (1974–present) Wayne E. Crill Endowed Professor, University of Washington, Department of Physiology and Biophysics (2005–present) HONORS AND AWARDS (SELECTED): Kenneth S. Cole Award of the Biophysical Society Membrane Biophysics Subgroup (1975) Mathilde Solowey Award in Neurosciences from NIH Foundation for Advanced Education in the Sciences (1976) Member of NIH NINDS Physiology Study Section (1981–1984) National Academy of Sciences, U.S.A. (1986) Research Award from the McKnight Endowment Fund for Neuroscience (1988–1994) 3rd Annual Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research with Erwin Neher and Jean-Pierre Changeux (1990) Columbia University Louisa Gross Horwitz Prize for outstanding basic research in Biology or Biochemistry with Clay Armstrong (1996) 1999 Albert Lasker Award for Basic Medical Research, with Clay Armstrong and Roderick MacKinnon (1999) The 2001 Gairdner Foundation International Award with Clay Armstrong and Roderick MacKinnon (2001) Institute of Medicine (2002) Wayne E. Crill Endowed Professorship, Department of Physiology & Biophysics, University of Washington, Seattle (2005–) Doctorate of Science, honoris causa, The Rockefeller University (2008) Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K+ channels of axons can be distinguished by drugs such as tetrodotoxin and tetraethylammonium ion, and that their ionic selectivity can be understood by a limiting pore size, the selectivity fi lter, and by movements of ions through a series of saturable sites. -
Interacting Ions in Biophysics: Real Is Not Ideal
Biophysical Journal (2013) 104:1849 Interacting Ions in Biophysics: Real is not Ideal Bob Eisenberg Department of Molecular Biophysics Rush University Chicago IL 60612 USA and Department of Chemistry and Miller Institute University of California Berkeley CA 94720 USA May 1, 2013 Running Title: Ions in Solutions Interact File name is “Interacting Ions Real is not Ideal FINAL May 1-1 2013.docx” Ions in Solutions Interact Biophysical Journal (2013) 104:1849 Abstract Ions in water are important throughout biology, from molecules to organs. Classically, ions in water were treated as ideal noninteracting particles in a perfect gas. Excess free energy of each ion was zero. Mathematics was not available to deal consistently with flows, or interactions with other ions or boundaries. Non-classical approaches are needed because ions in biological conditions flow and interact. The concentration gradient of one ion can drive the flow of another, even in a bulk solution. A variational multiscale approach is needed to deal with interactions and flow. The recently developed energetic variational approach to dissipative systems allows mathematically consistent treatment of the bio-ions Na+, K+, Ca2+ and Cl− as they interact and flow. Interactions produce large excess free energy that dominate the properties of the high concentration of ions in and near protein active sites, ion channels, and nucleic acids: the number density of ions is often > 10 M. Ions in such crowded quarters interact strongly with each other as well as with the surrounding protein. Non-ideal behavior found in many experiments has classically been ascribed to allosteric interactions mediated by the protein and its conformation changes. -
Graduate Programs in Physiology and Biophysics (M.A./Ph.D.)
Graduate Programs in Physiology and Biophysics (M.A./Ph.D.) The Department of Physiology and Biophysics at Boston University School of Medicine 1 Table of Contents Revised March 2010 (Bullitt) I. Purpose and Background . 3 II. Administration of the Programs in Physiology and Biophysics . 4 III. Admission into the Program . 5 IV. The Path of a Graduate Student . 6 V. Course Requirements . 9 VI. Resources for the Programs . 12 Appendix A1. Course syllabi . 15 2 Graduate Programs in Physiology and in Biophysics (M.A./Ph.D.) I. Purpose and Background The Department of Physiology and Biophysics, under the aegis of Dr. David Atkinson as chair, brings together 21 active faculty members to provide excellence in research and graduate education. Research interests in the Department span the modern areas of Cellular Physiology and Molecular Biophysics, with strong concentrations in Structural Biology, Vision Research, Muscle Physiology, and the Biology and Physical Chemistry of Lipids. The faculty is nationally and internationally recognized as leaders in their chosen areas of research. The Department provides flexible graduate programs with pathways either leading towards a degree in Physiology or in Biophysics. The department offers these two programs in a strong, collegial environment to encompass and promote the diverse overlapping research of all members of the Department. The goal of a combined program in Physiology & Biophysics is to produce graduate students who understand the thermodynamic, chemical, electrical and structural aspects of biological systems at the atomic level and in the context of the cell and organism. This goal is particularly timely as it is in tune with the National Institutes of Health initiatives that encourage training across scientific and medical disciplines. -
Kinetic and Pharmacological Properties of the Sodium Channel of Frog Skeletal Muscle
Kinetic and Pharmacological Properties of the Sodium Channel of Frog Skeletal Muscle DONALD T. CAMPBELL and BERTIL HILLE From the Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195. Dr. Campbell's present address is the Department of Physiology, Yale University School of Medicine, New Haven, Connecticut 06510. A B S T R A C T Na channels of frog skeletal muscle are studied under voltage clamp and their properties compared with those of frog myelinated nerve. A standard mathematical model is fitted to the sodium currents measured in nerve and in muscle to obtain a quantitative description of the gating kinetics. At 5°C the kinetics in frog nerve and skeletal muscle are similar except that activation proceeds five times faster in nerve. Block of Na channels by saxitoxin is measured in nerve and in muscle. The apparent dissociation constants for the inhibitory complex are about 1 nM and not significantly different in nerve and muscle. Block of Na channels by external protons in muscle is found to have an apparent pKa of 5.33 and a voltage dependence corresponding to action of 27% of the membrane potential drop. Both values are like those for nerve. Shift of the peak sodium permeability-membrane potential curve with changes of external pH and Ca ++ are found to be the same in nerve and muscle. It is concluded that Na channels of nerve and muscle are nearly the same. INTRODUCTION This paper examines properties of the Na channel of frog muscle membranes under voltage clamp conditions. The guiding question to ask is if the Na channel of muscle is similar to that of nerves taken from the same species. -
Curriculum Vitae
Curriculum Vitae MICHAEL DANIEL CAHALAN, Ph.D. Department of Physiology & Biophysics Office Phone: (949) 824-7776 University of California Lab Phone: (949) 824-7776 Irvine, California 92697-4561 e-mail: [email protected] Lab: 285 Irvine Hall URL: http://crt.biomol.uci.edu/ EDUCATION Oberlin College: B.A. in Biology, 1970, Honors Research with Dr. Richard Levin University of Washington: Ph.D., 1974, Department of Physiology and Biophysics Laboratory of Dr. Bertil Hille Postdoctoral Training: University of Rochester, 1975. Department of Physiology, University of Pennsylvania, 1976-77. Marine Biological Lab, Woods Hole, MA Laboratory of Dr. Clay M. Armstrong FACULTY POSITIONS University of California, Irvine, California, Dept. of Physiology and Biophysics Assistant Professor, 1977 Associate Professor, 1983 Professor, 1985 Chair 1991-1995, 2007-present Distinguished Professor, 2010-present HONORS Phi Beta Kappa (junior year), 1969 Graduated Magna Cum Laude, 1970 Muscular Dystrophy Postdoc Award, 1976 NIH Research Career Development Award, 1982 Alexander von Humboldt Prize, Senior Scientist Award, Max Planck Institute for Biophysical Chemistry, Göttingen, West Germany, 1990 Athalie Clark Research Achievement Award, UCI, 1997 Kenneth S. Cole Award for Membrane Biophysics, Biophysical Society, 2000 Javits Neuroscience Investigator Award, NINDS, 2006-13 Henry Kunkel Society, elected 2008 Excellence in Teaching Award from medical students, 2009, 2011, 2013 U.S. National Academy of Sciences, elected 2010 UCI Distinguished Faculty Award for Research, -
2019 Historical Information
2019 HISTORICAL INFORMATION Table of Contents 5515 Security Lane, Suite 1110 Rockville, Maryland 20852 Founding of the Society .......................................... ii Phone: 240-290-5600 Fax: 240-290-5555 Officers & Council ............................................... ii [email protected] Biophysical Journal .............................................. ii www.biophysics.org The Biophysicist ................................................ ii Committees ................................................... ii Subgroups ................................................... iii Future Meetings ............................................... iii Past Officers .................................................. iv Past Executive Board Members .................................... iv Past Council Members .......................................... v Past Biophysical Journal Editors & Editorial Board Members .............. vii Past Annual Meetings ........................................... xii Past BPS Lecturers .............................................. xiii Past Symposia Chairs & Topics ................................... xiii Past Award Winners .......................................... xxi Constitution & Bylaws ......................................... xxviii This document is provided by the Biophysical Society for the personal use of the members of the Society. Any commer- cial use is forbidden without written autho- rization from an officer of the Society. The use of photocopies of these pages or por- tions thereof as mailing