Complete List of Talks and Posters Presented at SMBE 2018
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Protists and the Wild, Wild West of Gene Expression
MI70CH09-Keeling ARI 3 August 2016 18:22 ANNUAL REVIEWS Further Click here to view this article's online features: • Download figures as PPT slides • Navigate linked references • Download citations Protists and the Wild, Wild • Explore related articles • Search keywords West of Gene Expression: New Frontiers, Lawlessness, and Misfits David Roy Smith1 and Patrick J. Keeling2 1Department of Biology, University of Western Ontario, London, Ontario, Canada N6A 5B7; email: [email protected] 2Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4; email: [email protected] Annu. Rev. Microbiol. 2016. 70:161–78 Keywords First published online as a Review in Advance on constructive neutral evolution, mitochondrial transcription, plastid June 17, 2016 transcription, posttranscriptional processing, RNA editing, trans-splicing The Annual Review of Microbiology is online at micro.annualreviews.org Abstract This article’s doi: The DNA double helix has been called one of life’s most elegant structures, 10.1146/annurev-micro-102215-095448 largely because of its universality, simplicity, and symmetry. The expression Annu. Rev. Microbiol. 2016.70:161-178. Downloaded from www.annualreviews.org Copyright c 2016 by Annual Reviews. Access provided by University of British Columbia on 09/24/17. For personal use only. of information encoded within DNA, however, can be far from simple or All rights reserved symmetric and is sometimes surprisingly variable, convoluted, and wantonly inefficient. Although exceptions to the rules exist in certain model systems, the true extent to which life has stretched the limits of gene expression is made clear by nonmodel systems, particularly protists (microbial eukary- otes). -
The EMBL-European Bioinformatics Institute the Hub for Bioinformatics in Europe
The EMBL-European Bioinformatics Institute The hub for bioinformatics in Europe Blaise T.F. Alako, PhD [email protected] www.ebi.ac.uk What is EMBL-EBI? • Part of the European Molecular Biology Laboratory • International, non-profit research institute • Europe’s hub for biological data, services and research The European Molecular Biology Laboratory Heidelberg Hamburg Hinxton, Cambridge Basic research Structural biology Bioinformatics Administration Grenoble Monterotondo, Rome EMBO EMBL staff: 1500 people Structural biology Mouse biology >60 nationalities EMBL member states Austria, Belgium, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom Associate member state: Australia Who we are ~500 members of staff ~400 work in services & support >53 nationalities ~120 focus on basic research EMBL-EBI’s mission • Provide freely available data and bioinformatics services to all facets of the scientific community in ways that promote scientific progress • Contribute to the advancement of biology through basic investigator-driven research in bioinformatics • Provide advanced bioinformatics training to scientists at all levels, from PhD students to independent investigators • Help disseminate cutting-edge technologies to industry • Coordinate biological data provision throughout Europe Services Data and tools for molecular life science www.ebi.ac.uk/services Browse our services 9 What services do we provide? Labs around the -
The Macronuclear Genome of Stentor Coeruleus Reveals Tiny Introns in a Giant Cell
University of Pennsylvania ScholarlyCommons Departmental Papers (Biology) Department of Biology 2-20-2017 The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell Mark M. Slabodnick University of California, San Francisco J. G. Ruby University of California, San Francisco Sarah B. Reiff University of California, San Francisco Estienne C. Swart University of Bern Sager J. Gosai University of Pennsylvania See next page for additional authors Follow this and additional works at: https://repository.upenn.edu/biology_papers Recommended Citation Slabodnick, M. M., Ruby, J. G., Reiff, S. B., Swart, E. C., Gosai, S. J., Prabakaran, S., Witkowska, E., Larue, G. E., Gregory, B. D., Nowacki, M., Derisi, J., Roy, S. W., Marshall, W. F., & Sood, P. (2017). The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell. Current Biology, 27 (4), 569-575. http://dx.doi.org/10.1016/j.cub.2016.12.057 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/biology_papers/49 For more information, please contact [email protected]. The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell Abstract The giant, single-celled organism Stentor coeruleus has a long history as a model system for studying pattern formation and regeneration in single cells. Stentor [1, 2] is a heterotrichous ciliate distantly related to familiar ciliate models, such as Tetrahymena or Paramecium. The primary distinguishing feature of Stentor is its incredible size: a single cell is 1 mm long. Early developmental biologists, including T.H. Morgan [3], were attracted to the system because of its regenerative abilities—if large portions of a cell are surgically removed, the remnant reorganizes into a normal-looking but smaller cell with correct proportionality [2, 3]. -
Functional Effects Detailed Research Plan
GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data. -
Exploring the Structure and Function Paradigm Oliver C Redfern, Benoit Dessailly and Christine a Orengo
Available online at www.sciencedirect.com Exploring the structure and function paradigm Oliver C Redfern, Benoit Dessailly and Christine A Orengo Advances in protein structure determination, led by the Figure 1 shows that as the international genomics initiat- structural genomics initiatives have increased the proportion of ives gather pace, both the number of sequences and novel folds deposited in the Protein Data Bank. However, these protein families are still growing at an exponential rate, structures are often not accompanied by functional annotations although the rate of expansion of protein families is with experimental confirmation. In this review, we reassess the substantially less. This trend is also observed among meaning of structural novelty and examine its relevance domain families, which are 10-fold fewer (<10 000) than to the complexity of the structure-function paradigm. the number of protein families. By targeting these, the Recent advances in the prediction of protein function from structural genomics initiatives can aim to characterise the structure are discussed, as well as new sequence-based major building blocks of whole proteins and since these methods for partitioning large, diverse superfamilies into domains recur in different combination in the genomes, it biologically meaningful clusters. Obtaining structural data for will be an important step towards understanding the these functionally coherent groups of proteins will allow us to complete structural repertoire in nature. Furthermore, better understand the relationship between structure and the complement of molecular functions found within function. an organism is likely to be even fewer. For example, 97% of proteins in yeast can be assigned one or more of Address 4000 unique GO terms. -
Genetics Society News
July 2008 . ISSUE 59 GENETICS SOCIETY NEWS www.genetics.org.uk IN THIS ISSUE Genetics Society News is edited by Steve Russell. Items for future issues should be sent to Steve Russell, preferably by email to • Genetics Society Epigenetics Meeting [email protected], or hard copy to Department of Genetics, • Genetics Society Sponsored Meetings University of Cambridge, Downing Street, Cambridge CB2 3EH. The Newsletter is published twice a year, with copy dates of 1st June and • Travel, Fieldwork and Studentship Reports 26th November. • John Evans: an Appreciation Cocoons of the parasitoid wasp Cotesia vestalis on cabbage leaf in Taiwan. From the • Twelve Galton Lectures fieldwork report by Jetske G. de Boer on page 36. • My Favourite Paper A WORD FROM THE EDITOR A word from the editor ow soon until the $1000 based on the results of tests we genome is actually with barely understand! Here in the Hus and individual UK there is currently a sequencing is widespread? The moratorium, adhered to by publication of increasing most insurers, on the use of numbers of individual human genetic testing information for genome sequences suggests assessing life insurance that we should start to consider applications. It is important some of the implications that this remains in place and associated with the availability its effectiveness is reviewed of personal genetic well before the current information. In this issue we moratorium expires in 2011. present two articles reflecting The Human Genetics on his issue: a report from a Commission Genetics Society sponsored (http://www.hgc.gov.uk) meeting recently held in monitor issues relating to Cambridge organised by The genetic discrimination in the Triple Helix, an international UK and are a point of contact undergraduate organisation, as for those with any concerns in the Millennium Technology Prize. -
701.Full.Pdf
THE AVERAGE NUMBER OF GENERATIONS UNTIL EXTINCTION OF AN INDIVIDUAL MUTANT GENE IN A FINITE POPULATION MOT00 KIMURA' AND TOMOKO OHTA Department of Biology, Princeton University and National Institute of Genetics, Mishima, Japan Received June 13, 1969 AS pointed out by FISHER(1930), a majority of mutant genes which appear in natural populations are lost by chance within a small number of genera- tions. For example, if the mutant gene is selectively neutral, the probability is about 0.79 that it is lost from the population during the first 7 generations. With one percent selective advantage, this probability becomes about 0.78, namely, it changes very little. In general, the probability of loss in early generations due to random sampling of gametes is very high. The question which naturally follows is how long does it take, on the average, for a single mutant gene to become lost from the population, if we exclude the cases in which it is eventually fixed (established) in the population. In the present paper, we will derive some approximation formulas which are useful to answer this question, based on the theory of KIMURAand OHTA(1969). Also, we will report the results of Monte Carlo experiments performed to check the validity of the approximation formulas. APPROXIMATION FORMULAS BASED ON DIFFUSION MODELS Let us consider a diploid population, and denote by N and Ne, respectively, its actual and effective sizes. The following treatment is based on the diffusion models of population genetics (cf. KIMURA1964). As shown by KIMURAand OHTA (1969), if p is the initial frequency of the mutant gene, the average number of generations until loss of the mutant gene (excluding the cases of its eventual fixation) is - In this formula, 1 On leave from the National Institute of Genetics, Mishima, Japan. -
EMBO Facts & Figures
excellence in life sciences Reykjavik Helsinki Oslo Stockholm Tallinn EMBO facts & figures & EMBO facts Copenhagen Dublin Amsterdam Berlin Warsaw London Brussels Prague Luxembourg Paris Vienna Bratislava Budapest Bern Ljubljana Zagreb Rome Madrid Ankara Lisbon Athens Jerusalem EMBO facts & figures HIGHLIGHTS CONTACT EMBO & EMBC EMBO Long-Term Fellowships Five Advanced Fellows are selected (page ). Long-Term and Short-Term Fellowships are awarded. The Fellows’ EMBO Young Investigators Meeting is held in Heidelberg in June . EMBO Installation Grants New EMBO Members & EMBO elects new members (page ), selects Young EMBO Women in Science Young Investigators Investigators (page ) and eight Installation Grantees Gerlind Wallon EMBO Scientific Publications (page ). Programme Manager Bernd Pulverer S Maria Leptin Deputy Director Head A EMBO Science Policy Issues report on quotas in academia to assure gender balance. R EMBO Director + + A Conducts workshops on emerging biotechnologies and on H T cognitive genomics. Gives invited talks at US National Academy E IC of Sciences, International Summit on Human Genome Editing, I H 5 D MAN 201 O N Washington, DC.; World Congress on Research Integrity, Rio de A M Janeiro; International Scienti c Advisory Board for the Centre for Eilish Craddock IT 2 015 Mammalian Synthetic Biology, Edinburgh. Personal Assistant to EMBO Fellowships EMBO Scientific Publications EMBO Gold Medal Sarah Teichmann and Ido Amit receive the EMBO Gold the EMBO Director David del Álamo Thomas Lemberger Medal (page ). + Programme Manager Deputy Head EMBO Global Activities India and Singapore sign agreements to become EMBC Associate + + Member States. EMBO Courses & Workshops More than , participants from countries attend 6th scienti c events (page ); participants attend EMBO Laboratory Management Courses (page ); rst online course EMBO Courses & Workshops recorded in collaboration with iBiology. -
National Institute of Genetics Japan
NATIONAL INSTITUTE OF GENETICS JAPAN ANNUAL REPORT No. 20 1969 Publi8l&ed bll THE NATIONAL INS'ITI'UTE OF GENETICS Mitlima. Simoka-ken. Japtm 1970 Annual Report of the National Institute of Genetics No. 20, 1969 Published by The National Institute of Genetics, Japan 1970 CONTENTS General statement 1 Staff..................................... .. 2 Council............................................................ 5 Association for propagation of the knowledge of genetics... 5 Projects of research for 1969 ................ 6 Researches carried out in 1969 .......................... 9 1. Cytogenetics Segregation of three types of the largest No.1 (A-I) chromosome in Rattus rattus bred in a population room. YOSIDA, T. H. and TSUCHIYA, K. 9 Polymorphism of No.9 (A-9) and No. 13 (A-13) autosomes in Rattus rattus collected in Japan. YOSIDA, T. H. and TSUCHIYA, K. and MASUJI, H.......................................... 10 Frequency of chromosome polymorphism in Rattus rattus col- lected in East and Southeast Asia. YOSIDA, T. H. and TSUCHIYA, K. 11 Fl and F2 hybrids between Asian and Oceanian black rats with different karyotypes. YOSIDA, T. H., KATO, H. and SAKAKI- BARA, K.................................................... 13 Karyotypes of black rats, Rattus rattus, obtained from Honolulu, Hawaii. YOSIDA, T. H. and TSUCHIYA, K. 14 Local differences in the frequencies of chromosome polymorphism in the house rat, Rattus rattus, in Japan. YOSIDA, T. H., TSUCHIYA, K. and SONODA, J. 15 Karyotypes of Rattus bowersii collected in Malaysia. YOSIDA, T. H. and TSUCHIYA, K. 16 Protective effects of protamine sulfate on disintegration of isolated metaphase chromosomes. KATO, H., SEKIYA, K. and YOSIDA, T. H. 17 A preliminary study on the uptake of isolated nuclei by mam malian cells in vitro. -
Manipulating Underdetermination in Scientific Controversy: the Case of the Molecular Clock
Dartmouth College Dartmouth Digital Commons Open Dartmouth: Published works by Dartmouth faculty Faculty Work 9-1-2007 Manipulating Underdetermination in Scientific Controversy: The Case of the Molecular Clock Michael Dietrich Dartmouth College Robert A. Skipper University of Cincinnati Follow this and additional works at: https://digitalcommons.dartmouth.edu/facoa Part of the Biology Commons Dartmouth Digital Commons Citation Dietrich, Michael and Skipper, Robert A., "Manipulating Underdetermination in Scientific Controversy: The Case of the Molecular Clock" (2007). Open Dartmouth: Published works by Dartmouth faculty. 16. https://digitalcommons.dartmouth.edu/facoa/16 This Article is brought to you for free and open access by the Faculty Work at Dartmouth Digital Commons. It has been accepted for inclusion in Open Dartmouth: Published works by Dartmouth faculty by an authorized administrator of Dartmouth Digital Commons. For more information, please contact [email protected]. Manipulating Underdetermination in Scientiªc Controversy: The Case of the Molecular Clock Michael R. Dietrich Dartmouth College Robert A. Skipper, Jr. University of Cincinnati Where there are cases of underdetermination in scientiªc controversies, such as the case of the molecular clock, scientists may direct the course and terms of dispute by playing off the multidimensional framework of theory evaluation. This is because assessment strategies themselves are underdetermined. Within the framework of assessment, there are a variety of trade-offs between differ- ent strategies as well as shifting emphases as speciªc strategies are given more or less weight in assessment situations. When a strategy is underdetermined, scientists can change the dynamics of a controversy by making assessments using different combinations of evaluation strategies and/or weighting what- ever strategies are in play in different ways. -
The Average Number of Generations Until Fixation of a Mutant Gene in a Finite Population'
THE AVERAGE NUMBER OF GENERATIONS UNTIL FIXATION OF A MUTANT GENE IN A FINITE POPULATION' MOT00 KIMURA AND TOMOKO OHTA, National Institute of Genetics, Mishima, Japan Received July 26, 1968 A mutant gene which appeared in a finite population will eventually either be lost from the population or fixed (established) in it. The mean time until either of these alternative events takes place was studied by WATTERSON(1962) and EWENS(1963). They made use of a method previously announced by DARL- ING and SIEGERT(1953), and, independently by FELLER(1954). Actually, DARL- ING and SIEGERTrefer to its application to genetics. From the standpoint of population genetics, however, it is much more desirable to determine separately the mean time until fixation and that until loss. Since the gene substitution in a population plays a key role in the evolution of the species, it may be of particular interest to know the mean time for a rare mutant gene to become fixed in a finite population, excluding the cases in which such a gene is lost from the population. In the present paper, a solution to this problem will be presented together with Monte Carlo experiments to test some of the theoretical results. Throughout this paper, the senior author (M. K.) is responsible for the mathematical treatments, while the junior author (T. 0.) is responsible for the numerical treatments based on computers. BASIC THEORY Let us consider a diploid population consisting of N individuals and having the variance effective number Ne, which may be different from the actual number (for the definition of Ne, see KIMURAand CROW1963). -
Estimation of the Spontaneous Mutation Rate in Heliconius Melpomene
Estimation of the Spontaneous Mutation Rate in Heliconius melpomene The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Keightley, Peter D., Ana Pinharanda, Rob W. Ness, Fraser Simpson, Kanchon K. Dasmahapatra, James Mallet, John W. Davey, and Chris D. Jiggins. 2014. “Estimation of the Spontaneous Mutation Rate in Heliconius melpomene.” Molecular Biology and Evolution 32 (1): 239-243. doi:10.1093/molbev/msu302. http://dx.doi.org/10.1093/ molbev/msu302. Published Version doi:10.1093/molbev/msu302 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:13890662 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Estimation of the Spontaneous Mutation Rate in Heliconius melpomene Peter D. Keightley,*,1 Ana Pinharanda,2 Rob W. Ness,1 Fraser Simpson,3 Kanchon K. Dasmahapatra,3,4 James Mallet,3,5 John W. Davey,2 and Chris D. Jiggins2 1Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom 2Department of Zoology, University of Cambridge, Cambridge, United Kingdom 3Department of Genetics, Evolution and Environment, University College London, London, United Kingdom 4Department of Biology, University of York, York, United Kingdom 5Department of Organismic and Evolutionary Biology, Harvard University *Corresponding author: E-mail: [email protected]. Associate editor:JohnParsch Abstract We estimated the spontaneous mutation rate in Heliconius melpomene by genome sequencing of a pair of parents and 30oftheiroffspring,basedontheratioofnumberofdenovoheterozygotes to the number of callable site-individuals.