Autism Spectrum Disorder

Total Page:16

File Type:pdf, Size:1020Kb

Autism Spectrum Disorder SPRING 2014 HALDIMAND-NORFOLK HEALTH UNIT COMMUNICATION MATTERS A NEWSLETTER FOR PARENTS, TEACHERS, EARLY LEARNING PROVIDERS AND CAREGIVERS OF PRESCHOOL-AGED CHILDREN. Autism spectrum disorder The last time we featured the topic of autism The following table highlights the most important differences between the DSM-5 and in Communication Matters was 2002. the previous edition, DSM-4. A lot has changed since then! More DSM IV DSM V people receive this diagnosis now than Diagnostic Labels Autism Spectrum Disorders Autism Spectrum Disorder: ever. Scientists are working hard to identify include: Level 1, Level 2, Level 3 the causes of autism. And in Ontario, the • Autistic Disorder, (Levels are defined by Ministry of Children and Youth funds a • Asperger’s Disorder, how much support the range of services for children with autism • PDD-NOS (Pervasive individual needs) and their families. Developmental Disorder Not Otherwise Specified) In this issue, we’ll look at some of the Criteria for diagnosis • Impairments in • Impaired Social recent information available about Autism Communication Communication and/or Spectrum Disorder. • Impairments in Social Interaction Interaction • Restricted and/or • Restricted Interests and Repetitive Behaviors What is Autism Spectrum Repetitive Behaviours. Disorder (ASD)? Age of diagnosis Geared towards Symptoms must show in Autism spectrum disorder is a neurological identification in school-aged early childhood even if condition. It affects the way the brain children diagnosis isn’t made until functions and results in difficulties with later. social communication. People with the disorder also exhibit unusual patterns of down to a few things that may have a in the old diagnosis, social skills and behaviour, activities and interests. profound effect on people with ASD and communication were considered their families: separately. The new version recognizes How is ASD diagnosed? • People who were previously identified the integration of these important skill as having Asperger’s or PDD-NOS will areas. We don’t yet have a medical test that can now be identified as having ASD. That • Identification by level may help to diagnose autism. Instead, specially trained doesn’t at all change who they are. But ensure that children receive the physicians and psychologists administer labels are part of our self-identity. If support they need in social and school autism-specific behavioral evaluations. They you or your child had come to terms settings. follow the guidelines laid out in a book with a diagnosis or Asperger’s or • The new version reflects recent called the Diagnostic and Statistical Manual PDD-NOS only to have it changed to research into the unusual behaviors (DSM). ASD now, you may experience initial shown by many people with ASD. anxiety and confusion. If this affects It recognizes that people with One of the biggest recent changes in the your family, be sure to discuss it with ASD often have difficulties with field of autism came in 2013 with the your child’s doctor. sensory processing. You’ll find more publication of the 5th edition of the DSM, • Social communication problems have information about sensory processing commonly referred to as the DSM-5. long been recognized to be the core later in this newsletter, under the All that technical-sounding language boils problem for people with ASD. But section “What does ASD look like?” COMMUNICATION MATTERS What causes ASD? There is no known single cause for autism, but it is generally accepted that the brain of a person with ASD is different in shape, structure and function than the brains of people without ASD. Researchers are investigating a number of theories, including the links among heredity, genetics and medical problems. In many families, there appears to be a pattern of autism or related disabilities, further supporting the theory that the disorder has a genetic basis. But is genetics the sole cause? Some It will take time for clinicians to use the How many children have researchers are exploring environmental DSM-5 before there’s agreement on its the diagnosis of ASD? factors such as viral infections, metabolic value – if there ever is. But it’s promising imbalances and exposure to environmental when a clinician like Dr. Stephen Kanne, The NEDSAC (National Epidemiological chemicals. executive director of the University of Database for the Study of Autism in Missouri Thompson Center for Autism Canada) looked at the number of children British doctor Andrew Wakefield caused a and Neurodevelopmental Disorders, can living with autism every year from 2003 to lot of families a lot of heartache when he say “”the new criteria lend themselves to 2010 in three areas of Canada. published a “study” in 1999 claiming that a more careful and tailored approach to vaccines caused autism. diagnosis” instead of “categoriz(ing) people The area closest to Haldimand-Norfolk according to an all or nothing checklist.” was Southeastern Ontario. Results there Even though it has since been proven showed an increase in autism in children that the data in the Wakefield study was The most important take away for families aged 2 to 5 years from .32 in 1000 (less false, it frightened many parents away is to realize that doctors can only diagnose than 1 in 300) in 2003 to .95 in 1000 (or (1 from potentially life-saving vaccines. It ASD – or rule it out as a diagnosis – if they in 100) in 2010. made some parents of children with ASD have excellent information about the child. experience tremendous guilt wrongly What a doctor sees in his office is rarely If that change wasn’t startling enough, the blaming themselves for their children’s the child’s best, or even typical behavior. U.S. based Centre for Disease Control difficulties. now says that 1 in 88 eight-year old As a parent, you know your child best. children and 1 in 54 eight-year old boys are Even though a specific gene has yet to If you are seeing a doctor because you living with the ASD diagnosis (March 2012). be identified, and researchers aren’t sure have concerns about your child’s social about environmental “triggers” that cause communication and behavior skills, be What’s going on?! autism to develop, we are getting closer to sure to be specific about your concerns. understanding the causes of autism. Write down your observations and bring NESDAC feels that changes in diagnostic that paper with you. Bring any reports criteria and better diagnostic skills are What does ASD look like? you have from other people, like a speech factors in this increase. For example, pathologist or your child’s preschool doctors are better now at picking up “If you’ve seen one child with autism, teacher. Make a note of any questions. the more subtle signs of autism in girls. you’ve seen….one child with autism.” Don’t be afraid to ask or tell anything! The Redpath Centre, a diagnostic centre Like all children, each child with ASD is in Toronto, reports that in the past five a unique and precious individual. People A diagnosis of ASD doesn’t change who years the male-to-female ratio of their with ASD may share certain behavioural, your child is, but it may help others 600 clients a year has risen from 80-20 to social and communication characteristics, understand him better. 60-40. But improved diagnostics doesn’t but they can vary widely in the effect tell the whole story. There is continued that autism has on their day-to-day lives. work on finding the core cause of autism. Sensory processing may be an important 2 SPRING 2014 COMMUNICATION MATTERS factor in creating the behaviours like lack of • bumping into people and things eye contact and hand flapping that worry • squeezing into tight places (e.g. behind parents. the couch) • giving and wanting very tight hugs News Flash! Temple Grandin, one of the world’s best • teeth-grinding or chewing on non-food Check out our new known and most accomplished adults items ONLINE REFERRAL with autism, has identified sensory issues • seeming to ignore things that are said FORM! as an area that needs much recognition to him and research. She writes about her own • wanting the TV turned up loud Go to hnhu.org /speech-referral- experiences of being overwhelmed by her • banging doors form. To access other information brain’s perception of the sounds and sights • flicking lights on and off like our Communication Checklist, of her environment. Grandin suggests • lining things up if you’re not sure what skills to that differences in sensory processing may • looking at things from unusual angles expect at different ages, visit hnhu. even contribute to the social problems • exploring things and people by smelling org/speech. You can also find our of people with ASD. In her book, The or licking them Referral Form there if you’d like your Autistic Brain, Grandin asks “...how can child to be seen for assessment. you socialize people who can’t tolerate the Children with motor planning difficulties environment where they’re supposed to be have trouble organizing their responses to social – who can’t practice recognizing the sensory input. Examples of motor planning treatments offer the most success. emotional meanings of facial expressions in difficulties include: Applied Behavioural Analysis (ABA) and social settings because they can’t go into a Intensive Behavioural Intervention (IBI) are restaurant?” • bumping into people and things designed to actively engage children with • playing with the same toy over and over communication, socialization, learning and Children with sensory processing difficulties in the same way behavioural problems. may be over-sensitive or under-sensitive • not imitating gestures or sounds to sensory information. Children who are • doing an activity just once (e.g.
Recommended publications
  • Autism, Asperger's & Theory of Mind a Literature Review
    Autism, Asperger©s & Theory of Mind A Literature Review Abstract: This literature review examines the history and pertinent research on Autism, a brain development disorder characterized by social impairment, communication difficulties and ritualistic behavior, and Theory of Mind, the ability for one to impute mental states to the self and to others. An introduction to these topics is followed by an investigation of whether Theory of Mind is missing in cases of autism, whether it is truly a core deficit of the disorder and what the ramifications are if this is the case. Also examined is whether this deficit is also present in cases of Asperger©s syndrome, where language is not delayed and IQs are usually high, as there has been controversy in this area. Possible biological connections are examined, including the Mirror Neuron system. A look at the world of treatment and adaptive technology solutions for the deficit is also undertaken. Lars Sorensen Cognition and Children©s Thinking Seminar : 295:590 Spring 2009 1 Introduction Theory of mind (ToM), the ability to impute mental states to the self and others and make reasoned decisions based on this information, is a cognitive skill usually found in typical children by the age of four or five years old. It is now believed to be a core deficit in cases of autism, a neurological disorder characterized by social and communication impairment, repetitive behavior and delayed speech. A great deal of research has been done in the last thirty years that focuses on this area. Do autistic children
    [Show full text]
  • The Cerebral Subject and the Challenge of Neurodiversity
    BioSocieties (2009), 4, 425–445 ª London School of Economics and Political Science doi:10.1017/S1745855209990287 The Cerebral Subject and the Challenge of Neurodiversity Francisco Ortega Institute for Social Medicine, State University of Rio de Janeiro, Rua Saˇ o Francisco Xavier 524, Rio de Janeiro CEP 20550-900, Brazil E-mail: [email protected] Abstract The neurodiversity movement has so far been dominated by autistic people who believe their condition is not a disease to be treated and, if possible, cured, but rather a human specificity (like sex or race) that must be equally respected. Autistic self-advocates largely oppose groups of parents of autistic children and professionals searching for a cure for autism. This article discusses the posi- tions of the pro-cure and anti-cure groups. It also addresses the emergence of autistic cultures and various issues concerning autistic identities. It shows how identity issues are frequently linked to a ‘neurological self-awareness’ and a rejection of psychological interpretations. It argues that the preference for cerebral explanations cannot be reduced to an aversion to psychoanalysis or psychological culture. Instead, such preference must be understood within the context of the dif- fusion of neuroscientific claims beyond the laboratory and their penetration in different domains of life in contemporary biomedicalized societies. Within this framework, neuroscientific theories, prac- tices, technologies and therapies are influencing the ways we think about ourselves and relate to others, favoring forms of neurological or cerebral subjectivation. The article shows how neuroscien- tific claims are taken up in the formation of identities, as well as social and community networks.
    [Show full text]
  • Diagnose, Understand, Embrace
    CMAJ Humanities Books Diagnose, understand, embrace The Autistic Brain: Thinking Across sensory aspects of autism, especially the Spectrum the importance of visual thinking and Temple Grandin and Richard Panek recognition of patterns. Houghton Mifflin Harcourt; 2013 Even though The Autistic Brain aims to be scientific and objective, it is still a very personal book. It is not possible to hysicians know that human expe- separate Grandin’s narrative from the rience is infinitely complex and subject matter, even though this is not, P variable. The insight that “every- strictly speaking, an autobiography or one is unique” sounds like a T-shirt slo- memoir. She talks about her personal gan or a platitude that a therapist might and professional life throughout, but in recite reassuringly, but doctors have both an incomplete way that leaves many a scientific and clinical perspective that unanswered questions. It is possible affirm the statement’s profound truth. that these gaps could be filled in by Every person is different, inside and out. reading Grandin’s other books or by Our preferences, sensitivities, strengths, watching the film about her life. But for emotions and cognitive processes com- the reader encountering her for the first bine in ways that can never be replicated, time, it is not always easy to piece the even if the effects of varying environ- story together. Even more striking is ments and experiences could somehow Harcourt Houghton Mifflin the impersonal way Grandin approaches be factored out of the equation. the personal. She repeatedly reports on At the same time, there are ways in nalist.
    [Show full text]
  • Atypical Core-Periphery Brain Dynamics in Autism
    REVIEW Atypical core-periphery brain dynamics in autism 1 2 Dipanjan Roy and Lucina Q. Uddin 1Cognitive Brain Dynamics Lab, National Brain Research Centre, Manesar, India 2Department of Psychology, University of Miami, Coral Gables, FL, USA Keywords: Core-periphery dynamics, Atypical timescales, Caudate, Core and contextual symptom severity, Sensory-motor network, Restricted and repetitive behaviors ABSTRACT The intrinsic function of the human brain is dynamic, giving rise to numerous behavioral an open access journal subtypes that fluctuate distinctively at multiple timescales. One of the key dynamical processes that takes place in the brain is the interaction between core-periphery brain regions, which undergoes constant fluctuations associated with developmental time frames. Core-periphery dynamical changes associated with macroscale brain network dynamics span multiple timescales and may lead to atypical behavior and clinical symptoms. For example, recent evidence suggests that brain regions with shorter intrinsic timescales are located at the periphery of brain networks (e.g., sensorimotor hand, face areas) and are implicated in perception and movement. On the contrary, brain regions with longer timescales are core hub regions. These hubs are important for regulating interactions between the brain and the body during self-related cognition and emotion. In this review, we summarize a large body of converging evidence derived from time-resolved fMRI studies in autism to characterize atypical core-periphery brain dynamics and how they
    [Show full text]
  • The Developmental Neurobiology of Autism Spectrum Disorder
    The Journal of Neuroscience, June 28, 2006 • 26(26):6897–6906 • 6897 Mini-Review Editor’s Note: Two reviews in this week’s issue examine the rapidly expanding interest in autism research in the neuroscience community. Moldin et al. provide a brief prospective on the overall state of research in autism. DiCicco-Bloom and colleagues summarize their presentations at the Neurobiology of Disease workshop at the 2005 Annual Meeting of the Society for Neuroscience. The Developmental Neurobiology of Autism Spectrum Disorder Emanuel DiCicco-Bloom,1 Catherine Lord,2 Lonnie Zwaigenbaum,3 Eric Courchesne,4,5 Stephen R. Dager,6 Christoph Schmitz,7 Robert T. Schultz,8 Jacqueline Crawley,9 and Larry J. Young10 1Departments of Neuroscience and Cell Biology and Pediatrics (Neurology), Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, 2University of Michigan Autism and Communication Disorders Center, Departments of Psychology and Psychiatry, University of Michigan, Ann Arbor, MI 48109-2054, 3Department of Pediatrics, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada, 4Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, 5Center for Autism Research, Children’s Hospital Research Center, San Diego, California 92123, 6Departments of Radiology, Psychiatry, and Bioengineering, University of Washington School of Medicine, Seattle, Washington 98105, 7Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University,
    [Show full text]
  • The Autistic Brain PDF Book
    THE AUTISTIC BRAIN PDF, EPUB, EBOOK Temple Grandin | 256 pages | 01 Apr 2014 | Ebury Publishing | 9781846044496 | English | London, United Kingdom The Autistic Brain PDF Book Bipolar disorder can be effectively treated with medication and psychotherapy. This is the tendency for creatures that inhabit deeper parts of the ocean to be much larger than closely related species that live in shallower waters. I didn't know what more Temple Grandin could say about autism, but she's come up with some cutting-edge information and thinking. We should find the strengths of all kids, all brains can change, people are particularly good at certain things because they may have brain damage here or larger brains there, etc. Of course then you run into funding issues and the fact that people want a diverse and individualized program for their children but don't want to pay beans for it Ignorance and misunderstanding are always difficult to overcome when they've become part of a society's belief system. Though it can at times feel a "little too light" due to too many diagrams, listed points, and a conflict in style between the two authors, to the point that it doesn't properly contain Grandin's "unique speaking style". Publishers Weekly. May 01, Richard Cytowic rated it it was amazing. Her insight is always a treat, she's a great embassador for people who have autism. New York Journal of Books. What are they passionate about? Also, since I listen while I drive, I can only devote part of my attention to listening to a book.
    [Show full text]
  • The Autistic Brain PDF Book
    THE AUTISTIC BRAIN PDF, EPUB, EBOOK Temple Grandin,Richard Panek | 256 pages | 01 Apr 2014 | Ebury Publishing | 9781846044496 | English | London, United Kingdom The Autistic Brain PDF Book Autism is a mental condition, initiates from early childhood, characterized by an issue in communication and forming relationships with others. You coordinated a large cross European study of infants at high familial risk of autism. So say, what is it that they would pay attention to, and that actually might give us more information in terms of how their brain is specialising, but also how might you design an intervention? Medically reviewed by Timothy J. And I can definitely get behind that. First, the researchers conducted functional MRI fMRI scans on 90 male participants, of which 52 had a diagnosis of autism and 38 did not. Left-right asymmetry is an important aspect of brain organization. So the only thing we parents and educators need to worry about is identifying what kind of patterns they are good at spotting and then developing this skill. Excellent read for anyone who has a child, a loved one, works with someone, or is on the autism spectrum. The first is an overview of the current state of research into the causes of autism, in turn divided into subsections on brain structure and genetics. View all the latest top news in the environmental sciences, or browse the topics below:. Unfortunately for those of us who live with autism on a daily basis, there is no "one-size fits all" approach to autism, but in her efforts to understand her own autism, Grandin has done a ton of research on the topic, often volunteering to be a guinea pig when a new neuro-imaging technology or technique is introduced.
    [Show full text]
  • Autism in the US: Social Movement and Legal Change Daniela Caruso Boston Univeristy School of Law
    Boston University School of Law Scholarly Commons at Boston University School of Law Faculty Scholarship 2010 Autism in the US: Social Movement and Legal Change Daniela Caruso Boston Univeristy School of Law Follow this and additional works at: https://scholarship.law.bu.edu/faculty_scholarship Part of the Education Law Commons Recommended Citation Daniela Caruso, Autism in the US: Social Movement and Legal Change, 36 American Journal of Law and Medicine (2010). Available at: https://scholarship.law.bu.edu/faculty_scholarship/571 This Article is brought to you for free and open access by Scholarly Commons at Boston University School of Law. It has been accepted for inclusion in Faculty Scholarship by an authorized administrator of Scholarly Commons at Boston University School of Law. For more information, please contact [email protected]. AUTISM IN THE US: SOCIAL MOVEMENT AND LEGAL CHANGE Boston University School of Law Working Paper No. 10-07 (March 23, 2010) Daniela Caruso This paper can be downloaded without charge at: http://www.bu.edu/law/faculty/scholarship/workingpapers/2010.html DANIELA CARUSO AUTISM IN THE US: SOCIAL MOVEMENT AND LEGAL CHANGE 36 AMERICAN JOURNAL OF LAW AND MEDICINE __ (2010) Abstract - The social movement surrounding autism in the US has been rightly defined a ray of light in the history of social progress. The movement is inspired by a true understanding of neuro-diversity and is capable of bringing about desirable change in political discourse. At several points along the way, however, the legal reforms prompted by the autism movement have been grafted onto preexisting patterns of inequality in the allocation of welfare, education, and medical services.
    [Show full text]
  • <856C75d> [Pdf] the Autistic Brain: Helping Different Kinds of Minds
    [pdf] The Autistic Brain: Helping Different Kinds Of Minds Succeed Temple Grandin, Richard Panek - book free The Autistic Brain: Helping Different Kinds Of Minds Succeed PDF, The Autistic Brain: Helping Different Kinds Of Minds Succeed PDF Download, The Autistic Brain: Helping Different Kinds Of Minds Succeed Download PDF, The Autistic Brain: Helping Different Kinds Of Minds Succeed by Temple Grandin, Richard Panek Download, Read The Autistic Brain: Helping Different Kinds Of Minds Succeed Full Collection Temple Grandin, Richard Panek, Free Download The Autistic Brain: Helping Different Kinds Of Minds Succeed Full Version Temple Grandin, Richard Panek, PDF The Autistic Brain: Helping Different Kinds Of Minds Succeed Full Collection, online free The Autistic Brain: Helping Different Kinds Of Minds Succeed, pdf download The Autistic Brain: Helping Different Kinds Of Minds Succeed, Download PDF The Autistic Brain: Helping Different Kinds Of Minds Succeed Free Online, read online free The Autistic Brain: Helping Different Kinds Of Minds Succeed, pdf Temple Grandin, Richard Panek The Autistic Brain: Helping Different Kinds Of Minds Succeed, Read Online The Autistic Brain: Helping Different Kinds Of Minds Succeed Book, Read Best Book The Autistic Brain: Helping Different Kinds Of Minds Succeed Online, Pdf Books The Autistic Brain: Helping Different Kinds Of Minds Succeed, Read The Autistic Brain: Helping Different Kinds Of Minds Succeed Full Collection, Read The Autistic Brain: Helping Different Kinds Of Minds Succeed Book Free, The Autistic Brain: Helping Different Kinds Of Minds Succeed pdf read online, The Autistic Brain: Helping Different Kinds Of Minds Succeed Ebooks Free, The Autistic Brain: Helping Different Kinds Of Minds Succeed Read Download, CLICK FOR DOWNLOAD It was funny from best to read but rather still surpasses yet in the end of the storyline.
    [Show full text]
  • Autism at the Beginning: Microstructural and Growth Abnormalities Underlying the Cognitive and Behavioral Phenotype of Autism
    Development and Psychopathology 17 ~2005!, 577–597 Copyright © 2005 Cambridge University Press Printed in the United States of America DOI: 10.10170S0954579405050285 Autism at the beginning: Microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism ERIC COURCHESNE,a,b ELIZABETH REDCAY,a JOHN T. MORGAN,a and DANIEL P. KENNEDYa aUniversity of California, San Diego; and bChildren’s Hospital Research Center, San Diego Abstract Autistic symptoms begin in the first years of life, and recent magnetic resonance imaging studies have discovered brain growth abnormalities that precede and overlap with the onset of these symptoms. Recent postmortem studies of the autistic brain provide evidence of cellular abnormalities and processes that may underlie the recently discovered early brain overgrowth and arrest of growth that marks the first years of life in autism. Alternative origins and time tables for these cellular defects and processes are discussed. These cellular and growth abnormalities are most pronounced in frontal, cerebellar, and temporal structures that normally mediate the development of those same higher order social, emotional, speech, language, speech, attention, and cognitive functions that characterize autism. Cellular and growth pathologies are milder and perhaps nonexistent in other structures ~e.g., occipital cortex!, which are known to mediate functions that are often either mildly affected or entirely unaffected in autistic patients. It is argued that in autism, higher order functions largely fail to develop normally in the first place because frontal, cerebellar, and temporal cellular and growth pathologies occur prior to and during the critical period when these higher order neural systems first begin to form their circuitry.
    [Show full text]
  • Redefining Autism
    www.kosmospublishers.com [email protected] DOI: 10.37722/JNPABR.20202 Review Article Journal of Neurology, Psychiatry and Brain Research JNPBR-147 ISSN: 2641 -6816 Redefining Autism David Rowland* Canadian Association for Neuroscience, Independent Researcher registered with ORCID, Canada Received Date: August 04, 2020; Accepted Date: August 12, 2020; Published Date: August 21, 2020 *Corresponding author: David Rowland, Canadian Association for Neuroscience, Independent Researcher registered with ORCID, Canada. Email: [email protected] Abstract difficulties with social integration were compensated for by the kind of high level of thought and experience that can lead to Autism is neither neurodevelopmental nor a disorder. It is exceptional achievements in later life. simply an inherent neurophysiological difference in how the brain processes information. We who are autistic live in a From intimate knowledge of my own brain, I can affirm that specialized inner space that is entirely intellectual, free from autism is not a withdrawal. It is simply a specialized way of emotional and social distractions. We observe the world in being in the world. We who are autistic observe the world in scholarly detail but without any emotional attachment to what scholarly detail, but without any emotional attachment to what we see. It may be time for the American Psychiatric Association we see. We are simply living in our own intellectual space. (APA) to consider if autism should continue to be included in its Diagnostic and Statistical Manual of Mental Disorders Epidemic of False Diagnoses (DSM-5). In 2020, the Centers for Disease Control (CDC) reported Introduction that 1 in 54 children is diagnosed with an autism spectrum disorder, for a prevalence rate of 1.85% of the population [5].
    [Show full text]
  • Functional Neuroimaging of Developmental Disorders: Lessons from Autism Research
    In Hillary FG, DeLuca J (eds), Functional Neuroimaging in Clinical Populations: Guilford. 2007:145-184. Functional neuroimaging of developmental disorders: Lessons from autism research Ralph-Axel Müller Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120; Department of Cognitive Science, University of California, San Diego, CA 92093 Any attempt to cover neuroimaging contributions to the large number of disorders that can be considered neurodevelopmental within a single chapter would be overly ambitious. Disturbances or defects can hit the developing nervous system in uncountable different sites and ways, and the resulting spectrum of impairments is vast. In a first approach, neurodevelopmental disorders can be grouped into three distinct classes: (i) Disorders that result from some kind of disturbance (e.g., neuromigrational) or lesion (e.g., stroke) during intrauterine or early postnatal phases; (ii) those caused by defects of a single gene or a well-defined chromosomal locus; and (iii) those known to be predominantly genetic in nature, but involving multiple different genetic (and epigenetic) risk factors. Among the disorders of type (i), there are subtypes that demonstrate the astounding potential of the developing brain for compensatory reorganization. The most positive examples of developmental plasticity come from cases of perinatal or early postnatal stroke, or from neurodegenerative diseases such as Sturge-Weber syndrome or Rasmussen’s encephalitis, which usually affect only one cerebral hemisphere, leaving the other intact. For instance, behavioral studies have documented the often surprisingly good language outcome in early left-hemisphere lesion patients (Nass & Stiles, 1996; Vicari et al., 2000), although etiology (Curtiss et al., 2001; Pulsifer et al., 2004) and presence or absence of seizures are important predictive variables (Isaacs et al., 1996; Muter et al., 1997).
    [Show full text]