The clear cell sarcoma functional genomic landscape Emanuele Panza, … , Mario R. Capecchi, Kevin B. Jones J Clin Invest. 2021. https://doi.org/10.1172/JCI146301. Research In-Press Preview Genetics Oncology Graphical abstract Find the latest version: https://jci.me/146301/pdf The Clear Cell Sarcoma Functional Genomic Landscape Emanuele Panza1,2,†, Benjamin B. Ozenberger3,†, Krystal Straessler1,3,†, Jared J. Barrott3, Li Li3, Yanliang Wang3, Mingchao Xie4, Anne Boulet1, Simon W. A. Titen1, Clinton C. Mason5, Alexander J. Lazar6, Li Ding4, Mario R. Capecchi1*, Kevin B. Jones3* 1Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA. 2Department of Medical and Surgical Sciences, University of Bologna, Italy. 3Departments of Orthopaedics and Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA. 4Departments of Medicine and Genetics, McDonnell Genome Institute, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA. 5Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA. 6Departments of Pathology and Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. †These authors contributed equally. Conflict of Interest Statement: The authors have declared that no conflict of interest exists. *Corresponding Authors: Mario R. Capecchi, PhD Kevin B. Jones, MD Department of Human Genetics Depts. of Orthopaedics and Oncological Sciences University of Utah School of Medicine University of Utah School of Medicine 15 North 2030 East, Room 5440 2000 Circle of Hope Drive, Room 3726 Salt Lake City, UT, 84112 Salt Lake City, UT 84112, USA email:
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[email protected] phone: 801-581-7096 phone: 801-585-0300 1 Abstract Clear Cell Sarcoma (CCS) is a deadly malignancy affecting adolescents and young adults.