Monthly Healthcare Review June 2017 IPOs The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

Last Last Financing Financing Company Name HQ Location Description Lead Manager Date Size (Millions) Developer of myoelectric prosthetic technology designed to offer expanded mobility for Myomo (MYO) 9-Jun-17 Cambridge, MA those suffering from neurological disorders and upper-limb paralysis. 7.90 Undisclosed Bank of America Merrill Lynch, China Merchants Shanghai, Provider of a highly customizable range of services for the discovery, development, and Securities, Morgan Wuxi Biologics (02269) 13-Jun-17 China manufacturing of biologics. 510.54 Stanley

Credit Suisse Securities, Deutche Bank Securities, J.P. Athenex (ATNX) 14-Jun-17 Buffalo, NY Developer of novel therapies created to treat cancer and immunomodulatory diseases. 66.00 Morgan Securities Surgical Science Göteborg, Developer of virtual reality simulators designed for medical training in the laparoscopic and Sweden (SUS) 19-Jun-17 Sweden endoscopic fields. 7.97 Undisclosed Imagion Biosystems Albuquerque, Developer of a technology that uses magnetic nanoparticles combined with antibodies and Focus Capital (IBX) 22-Jun-17 NM targets specific kinds of cancer cells. 8.92 Group Cowen and Company, J.P. Developer of an antibody drug conjugate cancer therapy created to precisely target highly Morgan Securities. Mersana Therapeutics 27-Jun-17 Cambridge, MA tailored drugs. 75.00 Leerink Partners Oppenheimer & Co., Raymond Avenue Therapeutics James and (ATXI) 27-Jun-17 New York, NY Developer of specialty pharmaceutical products focused on post-operative pain treatment. 33.00 Associates Axis Capital Limited, Citigroup Global Markets, Eris Lifesciences Ahmedabad, Manufacturer and distributor of pharmaceuticals focused on cardiovascular, diabetes, Credit Suisse (540596) 29-Jun-17 India gastroenterology and orthopedic segments. 270.32 Securities

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 1 Monthly Healthcare Review June 2017 IPOs The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

Last Last Financing Financing Company Name HQ Location Description Lead Manager Date Size (Millions) Bank of America Aileron Therapeutics Developer of a proprietary peptide technology platform to generate therapeutics for the Merrill Lynch, (ALRN) 29-Jun-17 Cambridge, MA treatment of cancer. 156.25 Jefferies J.P Morgan Dova Pharmaceuticals Charlottesville, Developer of investigational compounds for the treatment of thrombocytopenia in patients Securities, Jefferies, (DOVA) 30-Jun-17 VA with chronic liver disease undergoing an elective procedure. 75.06 Leerink Partners

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 2 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of a SaaS-based medical billing platform designed to provide automation technologies for medical groups, medical billing companies, PE Growth/ and PM/EMR vendors to transact directly with the major payers and Encoda 1-Jun-17 Tampa, FL Expansion eliminate the need for a clearinghouse. 1.50 Clearwell Group FCA Venture Partners, Developer of a health plan search platform for compliance and risk Undisclosed Vericred 1-Jun-17 New York, NY Early Stage VC management driven credentialing functions. 5.53 Investors Greenspring Associates, Greycroft Partners, Redpoint Ventures, Cross Creek Advisors, New Enterprise Associates, Provider of a health insurance service platform that partners with health Bessemer Venture systems to provide health plans and support relationships between Partners, Flare Bright Health 1-Jun-17 Minneapolis, MN Early Stage VC consumers and care providers. 160.00 Capital Partners

HenQ, Northzone, Health Innovations, Amsterdam, Developer of artificial intelligence-based imaging software used for faster Undisclosed Aidence 1-Jun-17 Netherlands Seed Round diagnosing of X-ray, MRI, and CT images. 2.48 Investors Accelerator/ Developer of a urine testing device designed to monitor infections in urine StreamSense Medical 1-Jun-17 Charlottesville, VA Incubator samples at home. 0.01 i.Lab at UVA Developer of a viral DNA/RNA detection device designed for the point Infinity Capital, AltraTech 1-Jun-17 Limerick, Ireland Early Stage VC of care testing of infectious viral diseases. 2.43 Kernel Capital

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 3 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

James W. Bullock, William A. Hawkins, Provider of detection instruments for cardiac diseases, such as atrial Piedmont Capital fibrillation detection, to deliver targeted therapies to affected areas within Partners, Solas CardioNXT 1-Jun-17 Westminster, CO Early Stage VC the heart. 2.10 Bioventures Operator of a biotechnology company intended to develop therapeutic vaccines for the treatment of autoimmune and inflammatory diseases Neovacs (ALNEV) 1-Jun-17 Paris, France PIPE using its proprietary Kinoid technology. 4.09 Kepler Cheuvreux Developer and manufacturer of neurosurgical instruments made of Undisclosed Kogent Surgical 1-Jun-17 Chesterfield, MO Later Stage VC lightweight, non-magnetic titanium. 0.05 Investors

Developer of medical devices that utilize micro-sensors, wireless technologies, and custom software applications, designed to improve Undisclosed ArthroMeda 1-Jun-17 Lowell, MA Later Stage VC surgical outcomes for patients undergoing joint replacement procedures. 1.50 Investors

Versant Ventures, SightLine Partners, Birchview Capital, BDC Capital's Developer of MRI-guided, laser-based systems for the ablation of brain Healthcare Venture Monteris Medical 1-Jun-17 Plymouth, MN Later Stage VC lesions. 26.58 Fund Vertex Ventures HC, Cambridge Innovation Capital, Developer of bicyclic peptides that combine antibody-like affinity and Longwood Fund, selectivity with small molecule-like tissue penetration, tuneable exposure, Novartis Venture flexible pharmacokinetics, and chemical synthesis, exploring the potential Fund, SROne, SV Cambridge, United of bicyclic peptides as targeted, titratable, and rapidly penetrant Health Investors, Bicycle Therapeutics 1-Jun-17 Kingdom Later Stage VC immunomodulators. 51.71 Atlas Venture

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 4 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Siparex Group, Edmond de Rothschild Investment Partners, Secondary CM-CIC Beuvry-la-Forêt, Transaction - Manufacturer of fine chemicals, pharmaceutical intermediates, and active Investissement, Minakem 1-Jun-17 France Private pharmaceutical ingredients. Undisclosed Groupe IRD

Aktia Kapitalförvaltning, Evli Group, Fondbolaget Fondita, Ilmarinen Mutual Pension Insurance Company, Op Asset Detection Technology Designer, manufacturer, and distributor of X-ray detectors and related Management, Sp- (Finland) (DETEC) 1-Jun-17 Oulu, Finland PIPE control systems. Undisclosed Rahastoyhtiö Developer of cancer immunotherapies designed to recognize and destroy tumor cells by activating an anti-tumor T-cell response with checkpoint inhibition to overcome a tumor's ability to mute the immune response, F-Prime Capital Checkmate enabling cancer patients with advanced cutaneous melanoma to begin Partners, Sofinnova Pharmaceuticals 2-Jun-17 Cambridge, MA Early Stage VC treatment successfully. 27.00 Ventures, venBio Operator of a bio pharma company developing microbiome modulating therapeutics and commercializing small molecule formulations and dietary Accelerator/ fibers that modulate the gut microbiome to confer protection against food New Venture ClostraBio 2-Jun-17 Chicago, IL Incubator antigens. 0.04 Challenge

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 5 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Novartis Venture Funds, Novo, Developer of therapeutics against genetic targets for neurodegenerative Undisclosed E-scape Bio 2-Jun-17 San Francisco, CA Early Stage VC diseases, including Alzheimer's Disease and Lewy Body Disease. 46.00 Investors Provider of a dental practice platform that connects dentists with patients , helping them attract new patients, replace cancelled appointments, and fill Undisclosed Windchime Health 2-Jun-17 Alamo, CA Angel bookings. 0.18 Investors Owner and operator of an evidence-based data analytics company intended to empower management and employees to take charge of their Undisclosed TruDataRx 2-Jun-17 Norwich, VT Angel pharmacy costs and clinical effectiveness. 0.28 Investors Developer of a non-invasive single treatment therapy intended to address the problem of myopia and has a real-time ultrasound sensing for accurate Undisclosed TECLens 2-Jun-17 New York, NY Angel prescription tuning. 1.16 Investors Developer of wearable and implantable sensors designed to capture physiological data for data streaming to understand vital sign patterns and Undisclosed PhysIQ 2-Jun-17 Naperville, IL Later Stage VC detect deviations that may indicate a change in health. 6.82 Investors Golden Leaf Holdings Undisclosed (GLH) 2-Jun-17 Toronto, Canada PIPE Producer and distributor of medical cannabis and cannabis extracts. 25.91 Investors Zicom Holdings, Developer of a one-second glaucoma laser treatment aimed at replacing Rimonci Capital, Belkin Laser 4-Jun-17 Tel Aviv, Israel Early Stage VC eye drops. 3.95 Horizon 2020

BioGeneration Ventures, INKEF Amsterdam, Developer of genomics and immunotherapy technologies created to Capital, Oxford Scenic Biotech 5-Jun-17 Netherlands Early Stage VC unlock genetic suppressors as a new class of drug targets. 7.18 Sciences Innovation

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 6 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Brandon Capital, Uniseed, UniQuest, Developer of novel therapies with anti-inflammatory properties developed Emory University, for the treatment of hot flashes in women with breast cancer who are Centrosome QUE Oncology 5-Jun-17 Atlanta, GA Early Stage VC receiving anti-estrogen therapy. 16.00 Ventures Keele, United PE Growth/ Manufacturer and marketer of calcium compound biologics to regenerate Biocomposites 5-Jun-17 Kingdom Expansion and repair bone and soft tissue. Undisclosed TA Associates Provider of a genomic dataset-based application intended to make genome exploration approachable and inexpensive for an average consumer and Undisclosed Seeq Labs 5-Jun-17 New York, NY Seed Round researcher. 1.00 Investors Developer of a cloud-based healthcare IT platform that solicits, tracks, captures, and evaluates rebate contract negotiations between payers and West Palm Beach, pharmaceutical manufacturers and upgrades medicines to systematized Undisclosed Quantuvis 5-Jun-17 FL Angel software. 1.50 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 7 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Vertex Ventures HC, Aisling Capital, Cochlear, New Enterprise Associates, Lightstone Ventures, Medtronic, Trellis Health Ventures, Richard King Mellon Foundation, Windham Venture Partners, Sightline Partners, Developer of an open-canal hearing device for transmitting sound to the Undisclosed EarLens 5-Jun-17 Menlo Park, CA Later Stage VC ear. 118.00 Investors Viking Global Investors, Redmile Group, Sphera Funds Mana, New Leaf Venture Developer of kinase-inhibiting drugs, including tumor-targeted therapies Partners, and immuno-targeted therapies, designed to treat cancer and Undisclosed Deciphera 5-Jun-17 Waltham, MA Later Stage VC immunological diseases. 52.30 Investors Activate Venture Provider of a SaaS-based digital medication encyclopedia to help Partners, LiveOak Digital Pharmacist 6-Jun-17 Austin, TX Early Stage VC community pharmacists communicate with consumers. 6.50 Venture Partners

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 8 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Ascension Ventures, Follow on Accuitive Medical Ventures, GE Ventures, InterWest Healthcare Partners, Industry Ventures, InterWest Partners, Patricia Industries, KBL Healthcare Ventures, New Leaf Venture Partners, Onset Ventures, Developer of a non-invasive medical device designed to transform Pfizer, Polaris neurohealth with non-drug treatments using MRI-strength magnetic field Venture Partners, NeuroStar 6-Jun-17 Malvern, PA Later Stage VC pulses. 15.00 Three Arch Partners Developer of a cognitive functioning health platform designed to establish the global authority on cognition and its relationship to risk, outcomes, DigiTx Partners, Savonix 6-Jun-17 San Francisco, CA Early Stage VC and the development of innovative therapies. 5.10 Rethink Impact Momenta Pharmaceuticals Provider of analysis, characterization, and design of complex Foresite Capital (MNTA) 6-Jun-17 Cambridge, MA PIPE pharmaceutical products for autoimmune indications. 5.75 Management

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 9 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Operator of a biopharmaceutical company focused on the development of highly selective medicines for patients with genetically defined cancers by increasing use of genetic testing in cancer clinical medicine and improving Loxo Oncology chemistry approaches to building highly selective inhibitors against single Foresite Capital (LOXO) 6-Jun-17 Stamford, CT PIPE targets in the cancer cell. 4.21 Management

HighCape Partners, Connecticut Developer of cancer therapeutics that directly target the tumor Innovations, microenvironment, leveraging a novel tumor-localizing peptide Undisclosed Cybrexa Therapeutics 6-Jun-17 New Haven, CT Early Stage VC technology. 6.00 Investors

HighCape Partners, Provider of non-invasive surgical skin closure devices that do not MVM Life Science Zipline Medical 6-Jun-17 Campbell, CA Later Stage VC puncture skin. 12.00 Partners NeXeption, Developer of topical and systemic therapies designed to treat various Undisclosed Ralexar Therapeutics 6-Jun-17 Malvern, PA Early Stage VC dermatological conditions. 4.15 Investors Developer of an immunotherapy-based treatment for treating peanut ProTA Therapeutics 6-Jun-17 Australia Early Stage VC allergies in children. 7.40 OneVentures Smith & Nephew, Safeguard Scientifics, HealthQuest Capital, BioStar Ventures, Provider of a camera-enabled needle technology for orthopedic Undisclosed Trice Medical 6-Jun-17 King of Prussia, PA Later Stage VC diagnostics. 19.30 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 10 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Sparta Group, Ascension Ventures, Undisclosed Instylla 6-Jun-17 Waltham, MA Early Stage VC Developer of novel embolization platforms for vascular applications. 8.08 Investors Targeted Technology, Provider of surgical products designed to assist the surgeon in closing port Undisclosed neoSurgical 6-Jun-17 Dublin, Ireland Later Stage VC site defects in laparoscopic abdominal surgery. 5.50 Investors Developer of customized corporate wellness programs for medium and Innovative Wellness large size businesses and organizations to help employees manage and Undisclosed Solutions 6-Jun-17 Oakmont, PA Angel track their health. 0.80 Investors Operator of a data company that evaluates how epigenetic modifications and changes in DNA methylation are inherited and how they impact the Undisclosed Episona 6-Jun-17 Pasadena, CA Seed Round first pregnancy stages for male factor infertility. 4.00 Investors Developer of a long-term high-density data storage technology based on Undisclosed Dodo OmniData 6-Jun-17 San Marcos, CA Angel DNA nanotechnology 0.40 Investors Cambridge, United Developer of antibody products to address applications in the diagnosis Undisclosed Biosceptre International 6-Jun-17 Kingdom Angel and treatment of cancer. 1.01 Investors Undisclosed 3DBiopsy 6-Jun-17 Aurora, CO Angel Developer of 3D prostate biopsy technology. 1.44 Investors Yandex, Baring Developer of an on-demand digital clinic platform designed to connect Vostok Capital DOC+ 6-Jun-17 Moscow, Russia Early Stage VC doctors and patients. 5.00 Partners HealthCap Clarus, OrbiMed Israel, Manufacturer of pharmaceutical drugs that treat drainage openings in the Pontifax Venture corner of the eye and substantially reduces intraocular pressure among Capital, Salzman Tisbury Pharmaceutical 7-Jun-17 Beverly, MA Early Stage VC glaucoma sufferers. 32.00 Group, SRTX

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 11 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Pathbreaker Ventures, Anorak Ventures, Data Collective, New Provider of a technology-based platform that facilitates encoding of data Enterprise Catalog Technologies 7-Jun-17 San Francisco, CA Seed Round and information into DNA format. 5.00 Associates TransMontaigne Developer of laboratory-based and point-of-care assays that enable Partners, Blackbird precision dosing and counterfeit detection of biologic drugs, as well as Ventures, Keshif direct monitoring of blood concentrations of monoclonal antibody drugs Ventures, Vertical Abreos Biosciences 7-Jun-17 San Diego, CA Early Stage VC for dosage. 1.20 Venture Partners Developer of a blood clot detection test designed to analyze blood clotting Undisclosed Stasys Medical 7-Jun-17 Seattle, WA Early Stage VC disorders and platelet dysfunction. 1.25 Investors

Developer of medical skincare products based on glycoproteins designed to help in cell renewal, new collagen development, skin hydration, and Undisclosed Sente 7-Jun-17 Carlsbad, CA Later Stage VC gradually lightening the appearance of pigmented lesions. 4.99 Investors Owner and operator of a biotechnology company intended to develop Undisclosed Orpheus Bioscience 7-Jun-17 Manassas, VA Early Stage VC novel therapeutics for autoimmune disorders. 1.25 Investors Operator of a clinical information technology created to help in improving Undisclosed Glytec 7-Jun-17 Waltham, MA Later Stage VC insulin management and glycemic control. 4.06 Investors Undisclosed Fruit Street Health 7-Jun-17 New York, NY Angel Provider of a digital wellness and telemedicine platform. 6.28 Investors Developer of a pacesetter designed to provide automatic placement of tissue sections, reduce variation and cross-contamination, and control Undisclosed Aquaro Histology 7-Jun-17 Ann Arbor, MI Early Stage VC microtomes. 9.81 Investors

Product Provider of an online healthcare information platform designed to Patientory 7-Jun-17 San Francisco, CA Crowdfunding connect users of similar health interests via their health information. 7.20 Crowdfunding Chemical Computing PE Growth/ Developer of software that provides drug discovery applications to Altaris Capital Group 8-Jun-17 Montreal, Canada Expansion pharmaceutical, biotech, and academic researchers. Undisclosed Partners Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 12 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Foundation for Internet Accelerator/ Provider of an online platform intended to facilitate interaction between Development- Medbox (Platform) 8-Jun-17 Moscow, Russia Incubator clinics and the patients. 0.04 Initiatives Keiretsu Forum, KCK Global, Keiretsu Capital, Developer of a mechanical ventilator that enables and accelerates the Undisclosed Lungpacer Medical 8-Jun-17 Burnaby, Canada Angel recovery of ventilated patients. 19.62 Investors

Developer of a healthcare CRM that offers digital marketing solutions, Multiplier Solutions 8-Jun-17 Hyderabad, India Seed Round analytics to grow patient engagement, and revenue growth solutions. 1.50 Norwest Venture Provider of a diagnostics platform that integrates laboratory science and computational analysis to gain a comprehensive view of each individual's Undisclosed Whole Biome 8-Jun-17 San Francisco, CA Early Stage VC microbiome. 10.50 Investors Developer of a peptide-based immunotherapy platform for patients with RAS-mutated cancers and a virus-based immunotherapy platform based on engineered oncolytic viruses armed with potent immune-stimulating Undisclosed Targovax (TRVX) 8-Jun-17 Bærum, Norway PIPE trans genes for patients with solid tumors. 23.51 Investors

Fennec Pharmaceuticals Developer of specialty pharmaceutical products for the prevention of Undisclosed (FRX) 8-Jun-17 NC PIPE platinum-induced chemotherapy ototoxicity in pediatric patients. 7.60 Investors Undisclosed 4D Path 8-Jun-17 Belmont, MA Seed Round Provider of a technology to universally detect any cancer and its subtypes. 0.25 Investors Developer of a sanitizing appliance that uses non-thermal plasma to Undisclosed airPHX Environmental 9-Jun-17 Arlington, VA Angel eliminate carbon-based pathogens in the air and on surfaces. 0.75 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 13 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

SoundBoard Angel Fund, Connecticut Innovations, Developer of a wearable health monitoring device primarily for orthotics Bulldog Innovation and prosthetics that helps doctors measure and report compliance data Group, Simon and quality brace wear data for patients and physicians in order to reduce School Venture Wellinks 9-Jun-17 New Haven, CT Seed Round risk of surgery and re-injury. 0.91 Fund Developer of a drug that protects hair cells in the inner ear for the Undisclosed Metarmor 9-Jun-17 Glen Gardner, NJ Angel prevention of hearing loss and auditory damage. 0.36 Investors El Dorado Hills, PE Growth/ Designer and manufacturer of joint orthopedic implant devices, including Undisclosed Consensus Orthopedics 9-Jun-17 CA Expansion knee systems, hip systems, and knee cups. 2.08 Investors Steamboat Springs, Developer of orthotic, prosthetic, and casting devices designed to treat Undisclosed Click Medical 9-Jun-17 CO Angel orthopedic diseases. 0.41 Investors PE Growth/ Developer of customized tissue products for use in orthopedic, spinal, Undisclosed Aziyo Biologics 9-Jun-17 Richmond, CA Expansion sports medicine, and dermal applications. 12.00 Investors Developer of drugs intended to make advances in the field of therapeutics Undisclosed Alzheon 9-Jun-17 Framingham, MA Early Stage VC for Alzheimer's and other neurological disorders. 15.76 Investors Undisclosed AFTx 9-Jun-17 Westminster, CO Angel Developer of diagnostic equipment and other medical devices. 1.16 Investors AbbVie Ventures, Developer of cell therapies intended to treat solid tumors by re- HealthCap, Grazia CARMA Therapeutics 12-Jun-17 Philadelphia, PA Early Stage VC engineering macrophages. 2.35 Equity, IP Group Developer of novel molecular biology technologies to examine disease- Arboretum related genes, improve next generation sequencing sample preparation for Ventures, Mercury Illumina and Ion Torrent platforms, and accelerate sample preparation for Fund, Undisclosed Swift Biosciences 12-Jun-17 Ann Arbor, MI Later Stage VC DNA sequencing. 12.24 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 14 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of a healthcare device controlled by Bluetooth that creates AZ Crown gentle air pulses in the ear canal to collect information and adjust Investments, treatment, enabling patients to treat migrane problems without the use of Undisclosed Nocira 12-Jun-17 Tempe, AZ Early Stage VC drugs. 3.90 Investors Operator of a biotechnology company focused on targeting the immune Abivax (ABVX) 12-Jun-17 Paris, France PIPE system to eliminate viral and inflammatory disease. 9.28 Bpifrance Entrepreneurs Accelerator/ Developer of a SaaS-based data analytics platform intended to analyze and Roundtable Basepair 12-Jun-17 New York, NY Incubator interpret raw data quickly and easily. 0.10 Accelerator Greenoaks Capital, Jackson Square Ventures, Justin Kan, Rahul Mehta, Developer of a digital pharmacy platform that offers medication Craig Sherman, Alto Pharmacy 12-Jun-17 San Francisco, CA Early Stage VC management and fulfillment. 23.00 Daniel Kan Owner of a pharmaceutical company with a key focus on development and manufacture of IP-led niche generics and bio-pharmaceuticals; it is also among the world's largest manufacturers of specialty soft gelatin Kohlberg Kravis Strides Shasun (STAR) 12-Jun-17 Bangalore, India PIPE capsules. 77.63 Roberts Provider of strategic medical communications services to global Lucid Group Loudwater, United PE Growth/ pharmaceutical companies, including medical education, medical Communications 12-Jun-17 Kingdom Expansion communication, strategic consultancy, and digital services. 14.22 LDC Next Generation Technology, Israeli Developer of a medical device for the prevention of post-surgical Office of Chief EIO Biomedical 12-Jun-17 Nazareth Illit, Israel Early Stage VC adhesion. Undisclosed Scientist Developer of a proprietary technology used for personalized cancer drug screening that allows physicians to match each patient with the optimally Next Generation Barcode Diagnostics 12-Jun-17 Nazareth Illit, Israel Early Stage VC potent medicine. Undisclosed Technology

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 15 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Qiming Venture Partners, Adams Street Partners, CVS Developer of a social network platform that offers people who are facing Health, The Westly the same chronic condition to connect with and learn from each other, ask Group, HealthTech MyHealthTeams 12-Jun-17 San Francisco, CA Later Stage VC questions, get referrals, and share tips. 7.30 Capital, 500 Startups Undisclosed Green Leaf Medical 12-Jun-17 Gaithersburg, MD Angel Producer of medical marijuana. 7.51 Investors ABS Capital Partners, Pablo Provider of biotechnological testing and specimen tracking services to Capital, BroadOak LabConnect 13-Jun-17 Seattle, WA Later Stage VC industries in the pharmaceutical sector. 24.50 Capital Alex Chesterman, Simon Franks, Taavet Hinrikus, Seedcamp, 500 Startups, London London, United Provider of a portable finger-prick blood test to monitor and track a range Co-Investment Thriva (Health) 13-Jun-17 Kingdom Seed Round of biomarkers that reveal the true state of individual's health. 1.94 Fund Developer of medical imaging devices intended to offer real time tumor Undisclosed Imatrex 13-Jun-17 Las Vegas, NV Angel tracking, low cost radiotherapy, and CT imaging. 0.25 Investors

ClearVision Equity Partners, Bootstrap Developer of a healthcare practice marketing and automation platform Incubation, Tech that engages patients and automates back-office workflow to streamline Coast Angels, Doctible 13-Jun-17 San Diego, CA Seed Round patient and provider interaction. 4.90 Keshif Ventures

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 16 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Health Catalyst Capital Management, PE Growth/ Undisclosed ReferWell 13-Jun-17 New York, NY Expansion Provider of a cloud-based medical referral platform. 3.23 Investors TVM Capital Life Science, DPE Deutsche Private Equity, Careventures, CIC Centogene 13-Jun-17 Rostock, Germany Later Stage VC Provider of genetic diagnostics services for rare diseases. 27.61 Capital

Developer of an AI platform that gathers information based on individual Undisclosed Kang Health 13-Jun-17 New York, NY Seed Round reported symptoms and provides diagnostic and treatment suggestions. 3.20 Investors San Luis Obispo, Developer of a medical device designed to provide peripheral intravenous Undisclosed I-V Access Technology 13-Jun-17 CA Angel catheters to patients. 1.56 Investors Provider of wellness programs that leverage cutting-edge research, personalized data, and tailored coaching supported by a clinical team to provide an individual with a scientific wellness program based on their personalized, unique genetic makeup and data provided from external Undisclosed Arivale 13-Jun-17 Seattle, WA Early Stage VC independent clinical labs and the participant's lifestyle. 13.60 Investors Village Capital, Provider of a SaaS healthcare platform intended to facilitate community- Undisclosed LivWell Health 13-Jun-17 San Francisco, CA Seed Round based healthcare services. 0.61 Investors Developer of a wireless, non-intrusive, and clinician-centered device that Clean Hands Safe improves and monitors hand sanitizer compliance among healthcare Hands 13-Jun-17 Atlanta, GA Corporate providers. Undisclosed SC Johnson

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 17 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Biomatics Capital, Reinet Investment, NFT Investment, Bay City Capital, 3W Partners Capital, Ditch Plains Capital Management, Kangmei Developer of a semiconductor-based synthetic DNA manufacturing Pharmaceutical, process that features a high throughput silicon platform that synthesizes Undisclosed Twist Bioscience 14-Jun-17 San Francisco, CA Later Stage VC DNA on silicon instead of on traditional 96-well plastic plates. 60.35 Investors Cigna, Civilization Ventures, Sanofi Genzyme BioVentures, U.S. Venture Partners, Andreessen Horowitz, Norwest Venture Partners, Humana, Kaiser Permanente Ventures, Providence Ventures, dRx Provider of a digital therapeutics program based on a diabetes prevention Capital, GE Omada Health 14-Jun-17 San Francisco, CA Later Stage VC program clinical trial designed to pioneer digital behavior change. 50.00 Ventures Producer and distributor of human tissue products for use in graft Grenville Strategic Lattice Biologics (LBL) 14-Jun-17 Scottsdale, AZ PIPE applications. 2.00 Royalty

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 18 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Provider of biotechnology research and development services intended to InterVest, KB create the next generation of antibody therapeutics by leveraging its cell Investment, LB Daejeon, South penetrating antibody platform that transforms antibodies to effectively Investment, Solidus Orum Therapeutics 14-Jun-17 Korea Early Stage VC target undruggable cytosolic targets. 8.00 Investment OSF Ventures, Hyde Park Angels, OCA Ventures, HLM Venture Partners, Furthur Fund, Sandalphon Capital, KohFounders, Regroup Therapy 14-Jun-17 Chicago, IL Later Stage VC Provider of an online mental healthcare service platform. 6.00 Impact Engine Phil Trubey, Mike Norman, Susan Tharp, Analytics Ventures, Hera Fund, Blaise Barrelet, Developer of a digital health platform created to transform cancer Undisclosed Curematch 14-Jun-17 San Diego, CA Early Stage VC treatment with precision medicine. Undisclosed Investors Developer of a digital healthcare device utilizing software and hardware technology with cloud-based data analytics and artificial intelligence capabilities that helps monitor, motivate patients, and maintain compliance Undisclosed SharkDreams 14-Jun-17 Raleigh, NC Angel and share the progress with doctors. 0.85 Investors

Developer of medical device technology designed to improve patient Undisclosed Saranas 14-Jun-17 Houston, TX Later Stage VC outcomes through early detection of internal bleeding complications. 4.00 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 19 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of an ultra-sensitive diagnostic platform intended to detect and quantify proteins present in blood and other body fluids at very low and Undisclosed Quanterix 14-Jun-17 Lexington, MA Later Stage VC previously undetectable concentrations. 8.50 Investors Secondary Plant Advanced Vandoeuvre-lès- Transaction - Technologies (ALPAT) 14-Jun-17 Nancy, France Private Provider of biotechnology research and development services. 0.01 Jean-Paul Fevre Developer of sepsis screening software designed to provide rapid and accurate primary, secondary, and tertiary assessment of sepsis and real- Undisclosed Luminare 14-Jun-17 Houston, TX Seed Round time feedback on a patient's condition to doctors. 0.50 Investors Yonghua Capital, Developer of novel endovascular medical devices created to treat cerebral Undisclosed Evasc Medical Systems 14-Jun-17 Vancouver, Canada Later Stage VC aneurysms. 7.35 Investors Abdi Ibrahim Pharmaceuticals, JSC Lancaster Developer of novel treatments for inflammatory, degenerative, and Group, Frank Leo, Ocugen 15-Jun-17 Malvern, PA Corporate neovascular diseases of the eye. 7.50 Dr. John Zhang

Apple Tree Partners, Johnson & Johnson Tusker Medical 15-Jun-17 Menlo Park, CA Early Stage VC Developer of medical devices for ear, nose, and throat treatments. 27.53 Innovation

Catapult Ventures, Perivoli Innovations Trust, Rainbow Seedfund, University of Oxford Endowment, Alderley Edge, Developer of prognostics tests designed to analyze cognitive decline and Undisclosed Cytox 15-Jun-17 United Kingdom Later Stage VC individual risk of developing Alzheimer's disease or other dementia. 3.36 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 20 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Foresite Capital, ARCH Venture Partners, Optum Developer of the first-ever brain biomarkers applying machine intelligence Ventures, Berggruen to human-computer interaction patterns with patented break-through Holdings, One Mind science and technology enabling ecological and continuous measure of Brain Health Impact Mindstrong 15-Jun-17 Palo Alto, CA Early Stage VC neuropsychological function. 14.35 Fund

Developer of medical imaging and diagnosis software that manages end-to- Median Technologies end medical imaging workflow using unique algorithms and combining it Undisclosed (ALMDT) 15-Jun-17 Valbonne, France PIPE with advanced image visualization and cloud-based imaging systems. Undisclosed Investors Saint-Petersburg, Operator of an R&D laboratory intended to develop new ways to tackle AGCT 15-Jun-17 Russia Early Stage VC HIV and oncology diseases. 0.77 RBV Capital FundRx, Developer of a biotechnology platform designed to offer advanced Undisclosed NeuroOne 15-Jun-17 Bloomington, MN Seed Round neuromonitoring and neuromodulating products. 1.50 Investors Producer of medical marijuana-based products intended to help Undisclosed National Biopharma 15-Jun-17 Chesapeake, OH Seed Round biotechnology companies develop drugs. 0.05 Investors Developer of internal bone fixation implants designed to advance the Undisclosed Metric Medical Devices 15-Jun-17 Helotes, TX Later Stage VC musculoskeletal repair standard of care. 0.75 Investors Developer of a non-invasive patient monitoring and respiratory diagnosis Undisclosed MediPines 15-Jun-17 Newport Beach, CA Angel device. 2.00 Investors Developer of wound care therapy devices and systems designed to promote healing at the wound bed by operating at lower pressures, eradicating biofilm, utilizing a non-adherent and antimicrobial dressing, Integrated Healing inhibiting tissue in-growth, and reducing pain associated with higher Undisclosed Technologies 15-Jun-17 Franklin, TN Later Stage VC pressures and dressing changes. 0.85 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 21 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of a sleep tracking technology product designed to automatically analyze a person's sleep stages in real-time and process the data with sophisticated machine learning algorithms that provide personalized metrics and AI powered tips that constantly evolve based on Xavier Niel, Laurent Dreem 15-Jun-17 San Francisco, CA Angel the person's sleeping habits. 11.5 Alexandre, MAIF Center for Innovative Technology Gap Funds, Alex Euler, Developer of a technology to identify a protein bio-marker in the early Undisclosed iTi Health 16-Jun-17 Crozet, VA Seed Round stages of pancreatic cancer. 0.75 Investors Provider of a mobile patient engagement platform that helps direct F-Prime Capital Wellframe 16-Jun-17 Boston, MA Early Stage VC communication between patient and caregiver. 15.00 Partners

Helsinn, Invitalia Ventures, Innogest SGR, Italian Angels Developer of biomimetic bone implants designed to treat severe fractures for Growth, and conditions, such as trauma and tumors, that result in extensive bone Undisclosed GreenBone Ortho 16-Jun-17 Faenza, Italy Early Stage VC loss. 9.28 Investors

MVM Life Science Partners, Leerink Revelation Partners, Pitango Venture Capital, ONSET Ventures, Aweida Venture Partners, Developer of minimally invasive medical devices designed to treat lumbar Undisclosed Vertos Medical 16-Jun-17 Aliso Viejo, CA Later Stage VC spinal stenosis. 28.78 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 22 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Tech Coast Angels, Grove Ventures, StartX, OVO Fund, Think +, Three Fish Capital, Robbie Armitano, Marc Developer of fitness and health wearable devices for noninvasive Abramowitz, monitoring and analysis of blood composition and physiological indicators Mahmoud Adi, Eric Spry Health 16-Jun-17 Palo Alto, CA Early Stage VC of energy, fitness, nutrition, hydration, and sleep. 5.50 Chen Undisclosed Oxygen Therapy 16-Jun-17 New York, NY PIPE Manufacturer of therapeutic drugs designed to address hypoxia. 0.24 Investors Secondary Developer of human cell-based therapies for the treatment of retinal and Cell Cure Transaction - neural degenerative diseases, such as macular degeneration, Parkinson's Neurosciences 18-Jun-17 Jerusalem, Israel Private disease, and multiple sclerosis. 12.75 Biotime Developer and manufacturer of personalized analytical services and Rillieux-la-Pape, implant systems created to bring long-lasting pain relief to patients who Undisclosed Medicrea (ALMED) 19-Jun-17 France PIPE undergo spinal surgery. 14.36 Investors

Developer and manufacturer of pharmaceutical products that offer local treatment of prostate cancer; its proprietary drug carriers can be used to develop new locally acting drugs for a wide range of cancers, such as tumors of the prostate, lung, ovarian, liver, brain, abdominal cavity, spine, Undisclosed LIDDS (LIDDS) 19-Jun-17 Uppsala, Sweden PIPE head, neck, bone, uterus, kidney, and bladder. 1.97 Investors

Provider of a patient compliance management and care coordination Cypress Growth application designed to organize, request, and send an entire family's Capital, Undisclosed ChartSpan 19-Jun-17 Greenville, SC Early Stage VC health records. 16.00 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 23 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Draper Fisher Jurvetson, UPMC, Hennepin, Froedtert, Providence Health & Services, Developer of a health platform designed to connect patients, doctors, and Undisclosed Xealth 19-Jun-17 Seattle, WA Seed Round digital treatments. 8.63 Investors

Provider of a bolus development software application designed to Undisclosed 3D Bolus 19-Jun-17 Halifax, Canada Early Stage VC improve accuracy and efficiency of radiation therapy for cancer treatment. 0.03 Investors

Shavit Capital Fund, VMS Investment Group, Israel Biotech Fund, Novartis, Clal Biotechnology Industries, Israel Developer of a pipeline of curative cellular and immune treatments for HealthCare Gamida Cell 19-Jun-17 Jerusalem, Israel Later Stage VC cancer and orphan genetic diseases. 40.00 Ventures

Provider of therapeutic devices for diagnosing and treating swallowing disorders, such as dysphagia, as well as nutritional food products tailored Undisclosed Swallow Solutions 19-Jun-17 Madison, WI Later Stage VC to the patient's diagnosed level of swallowing difficulty. 0.73 Investors

Developer of therapies designed to treat brain cancer by using tumor- homing stem cell technology and creating personalized genetically Undisclosed Falcon Therapeutics 19-Jun-17 Chapel Hill, NC Angel engineered neural stem cell therapies from the skin of cancer patients. 0.70 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 24 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Developer of advanced surgical drainage systems intended to address expensive and frequent complications in patients undergoing open-heart or open-lung surgery by using a series of integrated sensors, algorithms, and small battery-powered controllers to monitor wound site drainage, ensure proper evacuation, and provide critical data for clinical decision Undisclosed Esculon 19-Jun-17 Omaha, NE Angel support for the attending clinician. 1.55 Investors Eindhoven, Developer of a smart blanket designed to be used with preterm neonates Hugsy 19-Jun-17 Netherlands Seed Round and their parents in a neonatal intensive care unit. Undisclosed Crowdfunding

Illumina Ventures, Operator of a molecular diagnostics company designed to provide Merck, Undisclosed Serimmune 20-Jun-17 Santa Barbara, CA Early Stage VC diagnostics and therapeutics for autoimmune diseases. 8.00 Investors Provider of biopharmaceutical research and development services Merck Ventures, Geneva, intended to focus on therapeutics to modulate key culprits of Cancer Research iOnctura 20-Jun-17 Switzerland Seed Round immunosuppression in the tumor microenvironment. Undisclosed Technology Developer, formulator, and manufacturer of enzyme and probiotic-based dietary supplements; it also provides regulatory support and performs PE Growth/ specialty contract manufacturing services, including bulk blends, liquids, RoundTable Deerland Enzymes 20-Jun-17 Kennesaw, GA Expansion hard shell capsules, and tablets. Undisclosed Healthcare Partners T1D Fund, Developer of a Type 1 diabetes management system for people with Undisclosed Bigfoot Biomedical 20-Jun-17 Milpitas, CA Early Stage VC insulin-dependent diabetes and blood sugar control. 5.25 Investors Undisclosed RightEye 20-Jun-17 Bethesda, MD Angel Developer of an eye-tracking technology designed to measure visual skills. 7.28 Investors

Health Outcomes Provider of a SaaS-based content enablement platform that translates Undisclosed Sciences 20-Jun-17 Overland Park, KS Later Stage VC scientific models into automated evidence-based decision support services. 1.89 Investors Provider of a biotechnology platform intended to assist in preclinical proof of concept studies with established in vitro and in vivo assay Undisclosed Anelixis Therapeutics 20-Jun-17 Cambridge, MA Angel systems. 4.29 Investors Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 25 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Apple Tree Partners, Developer of novel therapies for inflammatory diseases, life-threatening Undisclosed Syntimmune 21-Jun-17 New York, NY Early Stage VC toxicities, and IgG-mediated autoimmune diseases. 50.00 Investors Ballast Point Ventures, Developer of medical devices to treat osteoarthritis and apply therapeutic Undisclosed Theragen 21-Jun-17 Manassas, VA Early Stage VC energy technologies for healing and pain relief. 10.39 Investors Developer of a patient-centered biotechnology platform that allows patients to bank their own bacteria before medical treatments that disturb Aberdeen, United the balances of bacteria in the gut, such as chemotherapy and long courses EnteroBiotix 21-Jun-17 Kingdom Seed Round of antibiotics. 0.65 Equity Gap

Developer of circulating cell therapies designed to treat autoimmune and Flagship Pioneering, rare metabolic diseases by modifying hematopoietic stem cells and turning Undisclosed Rubius Therapeutics 21-Jun-17 Cambridge, MA Early Stage VC them into red blood cells in culture. 120.00 Investors

Developer of a biomedical technology platform created to offer therapies that can overcome the body's natural immune system by shielding Sigilon 21-Jun-17 Cambridge, MA Early Stage VC implanted cells and devices from immune attacks and fibrosis. 23.50 Flagship Pioneering

Vélizy-Villacoublay, Novacyt (ALNOV) 21-Jun-17 France PIPE Developer, producer, and seller of automated cytology related services. 0.01 Jean Pierre Crinelli Accelerator/ Developer of virtual reality locomotion tools and an application designed VRemedy Labs 21-Jun-17 Cambridge, MA Incubator to reduce nausea. 0.02 Play Labs

Developer of a non-invasive form of brain stimulation that delivers low energy, alternating magnetic field stimulation in daily 30 minute sessions to Undisclosed NeoSync 21-Jun-17 Newton, MA Later Stage VC gently adjust a depressed brain toward a more normal state. 9.00 Investors Undisclosed Micell Technologies 21-Jun-17 Durham, NC Later Stage VC Developer of drug-delivery systems for cardiovascular diseases. 41.78 Investors Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 26 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Operator of a bio-pharmaceutical company focused on the development Undisclosed MalarVx 21-Jun-17 Seattle, WA Angel of in vitro culture systems for the malaria parasite. 1.05 Investors Developer of a mobilization device designed for different fields of Yverdon-les-Bains, physical rehabilitation, such as neurorehabilitation, orthopedics, and Undisclosed Lambda Health System 21-Jun-17 Switzerland Seed Round geriatrics. 0.76 Investors Developer of reservoir inhalers, capsule-based inhalers, dry powder Undisclosed Iconovo 21-Jun-17 Lund, Sweden Early Stage VC inhalers, pre-metered inhalers, and disposable unit-dose inhalers. 2.54 Investors Developer of a helios embolization device that creates an optimal bed for Undisclosed eLum Technologies 21-Jun-17 Columbus, OH Angel tissue regeneration. 4.35 Investors Operator of a late clinical-stage nano medicine company intended for the Nanobiotix (NANO) 22-Jun-17 Paris, France PIPE local treatment of cancer. 27.77 Bernd Muehlenweg

Life Science Angels, Keiretsu Capital, Developer of technologies to analyze single cells within complex biological Keiretsu Forum, systems designed to detect critical information not observable from bulk Undisclosed Mission Bio 22-Jun-17 San Francisco, CA Seed Round sample analysis. 13.26 Investors

Versant Ventures, MPM Capital, Fonds de solidarité Developer of oncology drugs designed to treat patients that target specific FTQ, Celgene, BDC Repare Therapeutics 22-Jun-17 Montreal, Canada Early Stage VC vulnerabilities of tumor cells. 68.00 Capital Secondary Developer of medical drugs designed for the treatment of cancer that Transaction - allows immune compromised cancer patients to be treated for Onxeo (ONXEO) 22-Jun-17 Paris, France Open Market complications caused by chemotherapy and radiotherapy. 0.09 Open Market

Aegis Capital PE Growth/ Developer of inhaled insulin products to control prandial blood sugar in Group, Undisclosed Dance Biopharm 23-Jun-17 Brisbane, CA Expansion adults with diabetes, without the need for injections. 4.89 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 27 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Owner and operator of a biotechnology company intended to focus on the development of nanoparticles for improved drug delivery to tumor Undisclosed Cello Therapeutics 23-Jun-17 San Diego, CA Early Stage VC sites in cancer patients. 1.60 Investors

GreyBird Ventures, Developer of 3D cell image analysis technology for the early detection of Undisclosed VisionGate 26-Jun-17 Phoenix, AZ Later Stage VC lung cancer. 24.29 Investors

PE Growth/ Designer, formulator, and manufacturer of complex molecules and M2i Life Sciences 26-Jun-17 Saint-Cloud, France Expansion chemicals for the animal health, crop health, and human health sectors. 13.25 IdInvest Partners Keiretsu Capital, Keiretsu Forum, Undisclosed Topical Remedy 26-Jun-17 Lake Oswego, OR Angel Provider of a clinical trial treatment for an undisclosed skin disease. 0.76 Investors MPM Capital, Aeries Capital, Developer of therapeutic antibodies for the treatment of cancer and other Affimed diseases that harness the patient's own immune system to destroy tumor Therapeutics, cells and their precursors by allowing the antibodies to bind to target EMBL Ventures, Amphivena molecules on the surface of tumor cells, T-cells, or NK-cells, leading to Undisclosed Therapeutics 26-Jun-17 San Francisco, CA Early Stage VC the breakdown of the cells. 19.50 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 28 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Pontifax Venture Capital & Phillip Forst, Catalyst CEL Fund, Quark Venture, GF Securities, Korea Investment Partners, Developer of bio-pharmaceutical therapies designed to treat genetic DSC Investments, Eloxx Pharmaceuticals 26-Jun-17 Rehovot, Israel Later Stage VC diseases by restoring full-length functional proteins. 30.00 Sevion Therapeutics

Sands Capital Ventures, Mithril Capital Management, Polaris Partners, NeoMed Management, OrbiMed Advisors, Borealis Ventures, Developer of a molecule-specific bio-pharmaceutical affinity purification Undisclosed Avitide 26-Jun-17 Lebanon, NH Later Stage VC technology designed to improve drug safety and establish biosimilarity. 12.00 Investors Developer of a biofeedback wristband designed to track and monitor Undisclosed Vardas 26-Jun-17 Sacramento, CA Angel stress, anxiety, ADHD, and insomnia diseases. 0.09 Investors Developer of single use disposable cartridges to capture stem and progenitor cells from peripheral and umbilical cord blood, bone marrow, Undisclosed SynGen 26-Jun-17 Sacramento, CA Later Stage VC and adipose tissue. 4.40 Investors Developer of a healthcare technology platform that offers medical and Undisclosed Rijuven 26-Jun-17 Wexford, PA Early Stage VC consumer health devices for comprehensive heart analysis. 2.28 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 29 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of a SaaS platform designed to instantly measure and analyze Undisclosed MuscleSound 26-Jun-17 Glendale, CO Angel glycogen levels. 0.57 Investors Undisclosed Harvest & Bloom 26-Jun-17 Chagrin Falls, OH Angel Provider of medical cannabis intended to treat patients. 0.55 Investors Developer of a healthcare device based on a novel neuromodulation Undisclosed Axon Therapies 26-Jun-17 New York, NY Early Stage VC approach designed to treat neurogenic syncope and heart failure. 1.30 Investors Developer of hands-free electronic smartglasses for visually impaired people that assists those suffering from eye conditions, such as macular Undisclosed NuEyes 27-Jun-17 Newport Beach, CA Early Stage VC degeneration, glaucoma, and retinitis pigmentosa. Undisclosed Investors

Arix Bioscience, OrbiMed, Edmond De Rothschild Investment Partners, Pontifax, OrbiMed Developer of gene therapy technologies for previously incurable genetic Israel Partners, SBI LogicBio Therapeutics 27-Jun-17 Cambridge, MA Early Stage VC and infectious diseases. 50.00 Holdings

BioGeneration Developer of a drug created to instantaneously restore blood clotting in Ventures, VarmX 27-Jun-17 Leiden, Netherlands Seed Round bleeding patients. Undisclosed InnovationQuarter Georgian Partners, Insulet, Mayo Clinic, Canaan Partner, Provider of a patient-monitoring platform for people with diabetes that Social Capital, syncs with diabetes devices, fitness wearables, and activity trackers for easy Medtronic, Samsung Glooko 27-Jun-17 Mountain View, CA Later Stage VC data capture. 35.00 Next

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 30 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Hatteras Venture Partners, Spectrum Health Ventures, Syno Capital, Mountain Group Partners, Laboratory Corporation of America Holdings, KTB Ventures, Provider of DNA test kits intended to treat rare genetically inherited DEFTA Partners, Orig3n 27-Jun-17 Boston, MA Early Stage VC diseases. 20.00 180 Degree Capital

Johnson & Johnson Innovation - JJDC, Seventure Partners, Mayo Clinic, Marius Nacht, Check Point Software Technologies, Developer of a microbiome-health management platform designed to Undisclosed DayTwo 27-Jun-17 Adanim, Israel Early Stage VC offer personalized nutrition and actionable insights. 12.00 Investors Developer of molecular diagnostic tests designed to help in early prediction of systemic metastasis in breast, prostate, lung, and colorectal MetaStat (MTST) 27-Jun-17 Boston, MA PIPE cancers. 9.60 Perceptive Advisors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 31 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Remiges Ventures, OrbiMed, SV Health Investors, Developer of a novel drug created to improve mitochondrial health as a Arix Bioscience, RM Mitoconix Bio 27-Jun-17 Yerushalayim, Israel Early Stage VC disease-modifying therapeutic for neurodegenerative diseases. 20.00 Global Partners Provider of engaging content through a host of delivery channels, Searchlight Capital PE Growth/ including digital waiting room screens in physician offices and hospitals Partners, Silver PatientPoint 27-Jun-17 Cincinnati, OH Expansion and interactive touchscreens in the exam room. 140.00 Point Capital Provider of a genomic information database designed to improve Undisclosed GenomeDx 27-Jun-17 Vancouver, Canada Later Stage VC treatment and outcomes of people with cancer. 6.25 Investors

AME Cloud Ventures, BioGenerator, Data Collective, 7percent Operator of a biotechnology company that provides full genome ventures, Refactor sequencing, sequence assembly, expressed sequence tagging, gene Capital, SV Tech alignments, and sequence analysis to enable detection and diagnosis of Ventures, David diseases, translating next-generation sequencing-based technologies into Lee, Jude Gomila, stable and complete end-to-end product solutions through R&D Paul Bucheit, Y Cofactor Genomics 28-Jun-17 Saint Louis, MO Later Stage VC developments that combine molecular, sequencing, and bioinformatics. 10.68 Combinator Ballast Point Ventures, Providence Ventures, CoxHealth, Intelligent Retinal Developer of cloud-based retinal imaging systems designed to offer early Undisclosed Imaging Systems 28-Jun-17 Pensacola, FL Later Stage VC detection for diabetic eye disease. 8.99 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 32 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Cenova Ventures, Sequoia Capital China, Canaan Partners, WuXi Healthcare Investment Consulting, Mission Vivace Therapeutics 28-Jun-17 San Mateo, CA Early Stage VC Provider of a novel targeted cancer therapy. 25.00 Bay Capital Developer of a non-wearable baby breathing monitoring system that uses a mobile wellness camera to detect heart rate, respiration, and skin Happiness Ventures, temperature at a distance by analyzing video in real time without any Undisclosed Cocoon Cam 28-Jun-17 Mountain View, CA Early Stage VC sensors attached to the body. 4.00 Investors Developer of molecular imprinted polymers (MIPS) and nanoMIPs/plastic antibodies that contain a single binding site for their target and are sufficiently small to be essentially soluble and can be fused to solid substrates, such as sensor surfaces, providing enterprises with Leicester, United ideal reagents for a wide range of applications including point-of-care MIP Diagnostics 28-Jun-17 Kingdom Early Stage VC diagnostics and in-field based testing. 0.39 Mercia Technologies

OrbiMed, Vivo Capital, Cormorant Pharmaceuticals, Rock Springs Zai Lab 28-Jun-17 Shanghai, China Later Stage VC Developer of therapeutics designed to address unmet medical needs. 30.00 Capital Developer of a loaner tray tracking software designed to provide instant scheduling and communications between hospital staff and vendor Undisclosed UniteOR 28-Jun-17 Portland, OR Later Stage VC representatives. 0.61 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 33 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Provider of oral pentoxifylline injections for the treatment of peyronie disease which causes pain, bruising, hematoma, and erectile dysfunction. The injections help reduce the blood viscosity and decrease the potential Undisclosed Eton Pharmaceuticals 28-Jun-17 San Diego, CA Early Stage VC for platelet aggregation. 20.06 Investors Developer of a technology designed to determine the location and age of Undisclosed Emerge Diagnostics 28-Jun-17 Carlsbad, CA Angel soft tissue injuries. 0.25 Investors

Wellington Management, Syncona, New Enterprise Associates, Redmile London, United Developer of a gene therapy designed to maintain and restore sight in Group, Undisclosed NightstaRx 28-Jun-17 Kingdom Later Stage VC patients with inherited retinal dystrophies. 45.00 Investors Developer of glycopolymer-based therapeutics to treat and to alter the progression of pulmonary diseases by disrupting mucus accumulation and Undisclosed Synspira 29-Jun-17 Boston, MA Angel bacterial bio-film invasion. 8.00 Investors

The Indus Entrepreneurs, Keiretsu Forum Northwest, Alliance of Angels, Pipeline Developer of a portable diagnostic device for diagnosing malaria and Angels, Elevate Hemex Health 29-Jun-17 Portland, OR Early Stage VC sickle cell diseases. 1.54 Capital

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 34 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions)

Bios Partners, Developer of a hand-powered rapid infuser that can deliver, on average, 1 Triangle Venture liter of crystalloid fluid through a 20-gauge IV catheter in less than 5 Alliance, Sovereign's minutes and allows medical providers to deliver a large volume of fluid Capital, Undisclosed 410 Medical 29-Jun-17 Durham, NC Early Stage VC through traditional IV access to patients during emergency situations. 5.35 Investors Goddard Mirexus Operator of a natural biomaterials company designed to commercialize Enterprises, Biotechnologies 29-Jun-17 Guelph, Canada Later Stage VC nanotechnology based on polysaccharide nanoparticles. 12.00 GreenSky Capital

M Ventures, Legend Capital, Sabey Corporation, Asset Developer of a synthetic class of diagnostic and therapeutic agents Management Indi Molecular 29-Jun-17 Culver City, CA Later Stage VC designed to replace traditional antibodies. 11.50 Ventures Novo, Canaan Developer of a protein stability platform and products for biologics that Partners, TPG Unchained Labs 29-Jun-17 Pleasanton, CA Later Stage VC help researchers measure multiple protein stability parameters. 13.00 Biotech TCP Venture Capital, Kapor Capital, Sand Hill Angels, Baltimore Provider of a mobile health platform for remote patient management Angels, Blue Jay emocha Mobile Health 29-Jun-17 Baltimore, MD Seed Round designed to streamline the continuum of care. 1.00 Syndicate Operator of a biotech company intended to provide treatment of benign Undisclosed Cytovation 29-Jun-17 Bergen, Norway Angel skin tumors. 2.35 Investors Developer of a needle-free device designed to deliver medications and Undisclosed PharmaJet 29-Jun-17 Golden, CO Early Stage VC vaccines intra-muscularly or subcutaneously. 3.00 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 35 Monthly Healthcare Review June 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Investor(s) Size Date (Millions) Developer of a robot-assisted surgery device designed to guide dental Undisclosed Neocis 29-Jun-17 Miami, FL Early Stage VC implant procedures. 15.00 Investors Provider of a telemedical platform that offers a home program that connects patients with caregivers and integrates with providers' EHRs, combined with predictive analytics based on continuous biometric Undisclosed Medically Home Group 29-Jun-17 Westport, CT Angel monitoring and a patient-facing portal. 4.00 Investors

Ysios Capital, Chemo Group, CG Health Ventures, Aurora Health Care, Babyscripts 29-Jun-17 Washington, DC Early Stage VC Developer of a virtual care platform for obstetrics. 5.70 P5 Health Ventures Secondary Operator of a bio-pharmaceutical company specializing in the discovery Idorsia Pharmaceuticals Allschwil, Transaction - and development of small molecules to meet significant unmet medical Jean-Paul Clozel, (IDIA) 29-Jun-17 Switzerland Private needs. Undisclosed Martine Clozel Developer of small molecule immunological therapeutics intended to treat Undisclosed Knopp Biosciences 30-Jun-17 Pittsburgh, PA Later Stage VC neurological, immunological, and hematological disorders. 17.45 Investors

Developer of molecular biology assays to identify, diagnose, and analyze Undisclosed DermTech 30-Jun-17 San Diego, CA Later Stage VC melanoma, prostate cancer, psoriasis, and various skin disorders. 7.07 Investors Developer of surgical equipment to treat congestive heart failure caused Undisclosed BioVentrix 30-Jun-17 San Ramon, CA Later Stage VC by ischemic cardiomyopathy. 14.5 Investors Developer of a prescription-only mobile app designed for the automated Undisclosed Amalgam Rx 30-Jun-17 Wilmington, DE Angel titration of all brands of basal insulin. 0.10 Investors

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 36 Monthly Healthcare Review June 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Developer of clinical decision support software designed to provide diagnostic imaging services and a platform that enables professional radiology groups, imaging centers, hospitals, and at-risk entities to make care decisions for their Siemens Healthineers Medicalis Kitchener, Canada 1-Jun-17 patients. Undisclosed Mercury Partners DirectMed Parts & (Newport Beach) Service San Diego, CA 1-Jun-17 Provider of medical imaging aftermarket parts, systems, and field services. Undisclosed Developer of drug-induced liver injury simulation software designed to help Simulations Plus DILIsym Services NC 1-Jun-17 ensure the safety of drug therapies during drug development. 9.50 Coloplast Comfort Medical Coral Springs, FL 1-Jun-17 Supplier of catheters and ostomy products. 160.00 Developer of enterprise managed care software designed to automate and streamline all critical functions of the medical management process through Mitchell International UniMed Direct Plano, TX 5-Jun-17 leveraging workflow optimization tools and evidence-based guidelines. Undisclosed WhiteCloud Designer and developer of a strategic analytic system intended for healthcare Relias Learning Analytics Boise, ID 6-Jun-17 performance management. Undisclosed Professional ASP Global Healing Solutions Crossville, TN 6-Jun-17 Supplier of disposable advanced wound care dressing. Undisclosed

Bain Capital Hugel (145020) Seoul, South Korea 6-Jun-17 Developer of pharmaceuticals, including Botox, Dysport, and Xeomin. 831.00 Genetics of Provider of laboratory services, including cytogenetics lab testing and Poplar Healthcare Memphis Memphis, TN 6-Jun-17 constitutional chromosome testing. Undisclosed Developer of proprietary predictive modeling technologies to support healthcare, Orthus Health BioSignia Cary, NC 6-Jun-17 employee wellness, insurance, and consumer health programs. Undisclosed

UCB Beryllium Discovery Bedford, MA 6-Jun-17 Provider of specialized drug discovery contract research services. Undisclosed American Cannabis Developer of standardized and repeatable cannabis extraction processes intended Innovations The Puration to deliver a consistent and high quality concentrate for infusion into consumer Conglomerated (PURA) Dallas, TX 7-Jun-17 food and beverage products. Undisclosed

Chesapeake Research Provider of independent IRB services to pharmaceutical companies, universities, Review MaGil IRB Rockville, MD 7-Jun-17 individual researchers, academic medical centers, and hospital systems. Undisclosed

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 37 Monthly Healthcare Review June 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) London, United Provider of a timer-enabled replacement cap for insulin pens designed to reduce Bigfoot Biomedical Timesulin Kingdom 8-Jun-17 health risks associated with diabetes. Undisclosed StatLab Medical Manufacturer of histology, cytology, and immunohistochemistry diagnostic Cressey & Company Products McKinney, TX 8-Jun-17 supplies. Undisclosed Developer of an imaging suite designed to connect all doctors, hospitals and Multiplier Solutions ABI Health Bangalore, India 8-Jun-17 patients with one single platform. Undisclosed Manufacturer and distributor of a device designed for cleaning, disinfection, and Miele Steelco (Italy) Treviso, Italy 9-Jun-17 sterilization applications. Undisclosed American Medical Manufacturer of healthcare instruments, including bariatrics, handles, illuminators, Group Solos Endoscopy Boston, MA 9-Jun-17 and laparoscopic instruments and accessories. Undisclosed Charterhouse Capital Operator of a specialty pharmaceutical group focused on prescription medicines Partners SERB Brussels, Belgium 9-Jun-17 that address rare and life-threatening diseases. Undisclosed Ricerca Biosciences (Chemical Division Olon In Ohio) Concord, OH 9-Jun-17 Provider of contract research and chemical development services. Undisclosed Lausanne, Developer of a wearable medical device providing clinical-grade motion analysis MindMaze Gait Up Switzerland 9-Jun-17 designed to help patients with Parkinson's and cerebral palsy. Undisclosed Al Jabal for Drugs and Medical Mr. Khalil Ghaleb Ali Appliances Al Jabal Company Sana'a, Yemen 9-Jun-17 Manufacturer and wholesaler of medicines and drugs. Undisclosed CancerGene Developer of a cloud-based genetic assessment platform designed to collect, Invitae Connect Dallas, TX 12-Jun-17 assess, and manage genetic family histories. 6.00 Manufacturer and distributor of cold chain packaging, infusion pumps and supplies, back packs and fanny packs for portable infusion pumps, and various Medical Specialties Attentus Medical other medical supplies for the compounding pharmacy, home infusion, specialty Distributors Sales Houston, TX 12-Jun-17 pharmacy, and HME markets. Undisclosed Provider of a prescription management platform designed to control healthcare PokitDok Oration Foster City, CA 13-Jun-17 purchases. Undisclosed MedCo Data (RCM Encoda Division) Tampa, FL 13-Jun-17 Provider of revenue cycle management services for the healthcare industry. Undisclosed

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 38 Monthly Healthcare Review June 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Developer of a next generation aortic valvuloplasty balloon for percutaneous and Venus Medtech InterValve Plymouth, MN 13-Jun-17 transapical aortic valve replacement procedures. Undisclosed BIOTREND Developer and distributor of complex organic chemicals intended for biomedical CliniSciences Chemikalien Köln, Germany 13-Jun-17 research. Undisclosed Provider of medical writing, bio-statistics, data management, and bio-analysis to Altasciences pharmaceutical and biotechnology companies in critical stage of drug Audax Private Equity Company Laval, Canada 13-Jun-17 development. Undisclosed

Provider of API technology development and scale-up services for complex small Eurofins Scientific Alphora Research Mississauga, Canada 13-Jun-17 molecules, including niche API’s, high potency, and cytotoxic compounds. Undisclosed Fidelio Capital and Developer of over-the-counter consumer healthcare products, including Premune Oystershell Drongen, Belgium 14-Jun-17 supplements, sun cream, and wound care products. Undisclosed Developer of a technology used to facilitate a broad range of applications and Eco Petroleum Immunotech drugs for the immuno-therapeutic treatment and prevention of HIV, AIDS, Solutions Laboratories Monrovia, CA 14-Jun-17 cancer, and other immuno-related disorders. Undisclosed Continuum Health Operator of a specialty-care services company that offers doctor recommended Alliance Captify Health Lenexa, KS 14-Jun-17 over-the-counter preparation products and programs. Undisclosed Sliedrecht, Developer and supplier of a cloud-based UMO database intended to provide a Main Capital Partners Verklizan Netherlands 16-Jun-17 universal platform for monitoring personal emergency alarms. Undisclosed Span-America Manufacturer of therapeutic and medical products, including medical bed frames, Savaria Medical Systems Greenville, SC 16-Jun-17 patient positioners, mattress overlays, and fall protection products. 80.20 Developer of a gene delivery platform to provide a pipeline of cutting-edge Intrexon Genvec Gaithersburg, MD 16-Jun-17 therapeutics and vaccines. 159.15 Alternate Medicine Friday Night Association Las Vegas, NV 16-Jun-17 Producer of medical marijuana. Undisclosed Developer of low molecular weight drugs for treating cardiovascular, Actelion Allschwil, cardiopulmonary, immunological, and infectious diseases, as well as metabolic and Johnson & Johnson Pharmaceuticals Switzerland 16-Jun-17 central nervous system disorders. 3000.06 Refine Support Santa Rosa, Developer of a soft and flexible suture-mesh-anchor breast-lifting technology that Sinclair Pharma System California 19-Jun-17 lifts and supports soft tissue. 11.30 Tahoe Investment Fujian Huitian Bio- Manufacturer and designer of pharmaceutical drugs created for targeting Group pharma Fuzhou City, China 19-Jun-17 autoimmune diseases. Undisclosed Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 39 Monthly Healthcare Review June 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Developer of integrated clinical software applications designed to improve coordination with other care settings for long-term and post-acute care facilities, MDI Achieve SigmaCare New York, NY 20-Jun-17 physicians, nurses and other medical professionals. Undisclosed

Catapult Therapy London, United Provider of biotechnology-related research and development services focused in Cell Medica TCR Kingdom 20-Jun-17 the development, delivery, and commercialization of cell and gene therapy. Undisclosed Sutures India Quality Needles Noida, India 22-Jun-17 Manufacturer of surgical needles used for ophthalmic surgery. 69.86 Manufacturer of instruments for rapid screening of total microbes and rapid AMETEK Mocon Brooklyn Park, MN 22-Jun-17 sample testing in the food and life sciences industries. 182.00 Developer of molecular detection, imaging, and illumination systems designed for Leonardo DRS Daylight Solutions San Diego, CA 23-Jun-17 multiple applications, including the life sciences industry. 150.00 SensoMotoric Developer of eye trackers and software products designed to analyze how visual Vineyard Capital Instruments Teltow, Germany 26-Jun-17 information is processed in different situations. Undisclosed Featherstone, HealthNet Homecare Biodose Services United Kingdom 26-Jun-17 Provider of homecare dispensary and delivery services. 2.52

Sentio (nerve Developer of a proprietary system that monitors nerve location during invasive DePuy Synthes monitoring system) Wixom, MI 27-Jun-17 spinal procedures. Undisclosed Physician Office Drug Inventory Developer of a cloud-based inventory and billing reconciliation system created to Besse Medical System OH 27-Jun-17 ensure proper billing and complete payment. Undisclosed Port Moody, Bunzl Western Safety Canada 28-Jun-17 Provider of personal protection equipment and first aid needs. Undisclosed

Developer of innovative antibody therapeutics targeting the classical pathway of the complement system and prevents the generation of critical inflammatory True North South San mediators and phagocytic markers not addressed by other therapeutic approaches Bioverativ Therapeutics Francisco, CA 28-Jun-17 that act by inhibiting the complement system further downstream. 825.00 Janssen (OTC Schaffhausen, Developer of products based on anti-fungal substances and are used to treat Trimb Healthcare Products) Switzerland 28-Jun-17 common fungal infections of the skin. Undisclosed

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 40 Monthly Healthcare Review June 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Developer of laboratory instruments using microfluidic chips for standardized sample analysis based on a multi-channel spectrometer for spectral analysis of Unchained Labs Trinean Ghent, Belgium 29-Jun-17 micro-liter droplets. Undisclosed Sanpower Group Dendreon Seattle, WA 29-Jun-17 Developer of targeted therapeutics for the treatment of cancer. 819.90

Source: Pitchbook Compiled By: Lea Keller and Morgan Reape 41