Formulary Table Indicates That the Suggested Dose Is Based on Pharmacologic Data Obtained in Some Species of Birds Other Than Poultry
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
The Role of Nanobiosensors in Therapeutic Drug Monitoring
Journal of Personalized Medicine Review Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring Vivian Garzón 1, Rosa-Helena Bustos 2 and Daniel G. Pinacho 2,* 1 PhD Biosciences Program, Universidad de La Sabana, Chía 140013, Colombia; [email protected] 2 Therapeutical Evidence Group, Clinical Pharmacology, Universidad de La Sabana, Chía 140013, Colombia; [email protected] * Correspondence: [email protected]; Tel.: +57-1-8615555 (ext. 23309) Received: 21 August 2020; Accepted: 7 September 2020; Published: 25 September 2020 Abstract: Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine. Keywords: biosensors; therapeutic drug monitoring (TDM), antibiotic; personalized medicine 1. Introduction The discovery of antibiotics (AB) ushered in a new era of progress in controlling bacterial infections in human health, agriculture, and livestock [1] However, the use of AB has been challenged due to the appearance of multi-resistant bacteria (MDR), which have increased significantly in recent years due to AB mismanagement and have become a global public health problem [2]. -
Efficacy of Recommended Drugs Against Soil Transmitted Helminths
RESEARCH Efficacy of recommended drugs against soil transmitted BMJ: first published as 10.1136/bmj.j4307 on 25 September 2017. Downloaded from helminths: systematic review and network meta-analysis Wendelin Moser,1,2 Christian Schindler,2,3 Jennifer Keiser1,2 1Department of Medical ABSTRACT 43.4% (23.5% to 63.3%; P=0.049) and the cure rates Parasitology and Infection OBJECTIVE fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to Biology, Swiss Tropical and To evaluate efficacies of anthelmintic drugs against 31.3%; P=0.027). Public Health Institute, PO Box, CH-4002 Basel, Switzerland soil transmitted helminths in terms of cure rates and CONCLUSIONS 2University of Basel, Basel, egg reduction rates. All four currently recommended drugs show Switzerland DESIGN limitations in their efficacy profile. While only 3 Department of Epidemiology Systematic review and network meta-analysis. albendazole showed good efficacy against hookworm and Public Health, Swiss Tropical and Public Health DATA SOURCES infection, all drugs had low efficacy againstT trichiura. Institute, PO Box, CH-4002 PubMed, ISI Web of Science, Embase, ScienceDirect, The decrease in efficacy of albendazole againstT Basel, Switzerland the Cochrane Central Register of Clinical Trials, and the trichiura over the past two decades is of concern. The Correspondence to: J Keiser findings indicate the need for strengthening efforts to [email protected] World Health Organization library database from 1960 until 31 December 2016. develop new drug treatments, with a particular focus Additional material is published on drugs against T trichiura. online only. To view please visit STUDY SELECTION the journal online. -
Full Text in Pdf Format
DISEASES OF AQUATIC ORGANISMS Published July 30 Dis Aquat Org Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. 11: Gyrodactylus sp. J. L. Tojo*, M. T. Santamarina Department of Microbiology and Parasitology, Laboratory of Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, E-15706 Santiago de Compostela, Spain ABSTRACT: A total of 24 drugs were evaluated as regards their efficacy for oral treatment of gyro- dactylosis in rainbow trout Oncorhj~nchusmykiss. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. Twenty-two of the drugs tested (aminosidine, amprolium, benznidazole, b~thionol,chloroquine, diethylcarbamazine, flubendazole, levamisole, mebendazole, n~etronidazole,mclosamide, nitroxynil, oxibendazole, parbendazole, piperazine, praziquantel, roni- dazole, secnidazole, tetramisole, thiophanate, toltrazuril and trichlorfon) were ineffective Triclabenda- zole and nitroscanate completely eliminated the infection. Triclabendazole was effective only at the screening dosage (40 g per kg of feed for 10 d), while nitroscanate was effective at dosages as low as 0.6 g per kg of feed for 1 d. KEY WORDS: Gyrodactylosis . Rainbow trout Treatment. Drugs INTRODUCTION to the hooks of the opisthohaptor or to ulceration as a result of feeding by the parasite. The latter is the most The monogenean genus Gyrodactylus is widespread, serious. though some individual species have a restricted distri- Transmission takes place largely as a result of direct bution. Gyrodactyloses affect numerous freshwater contact between live fishes, though other pathways species including salmonids, cyprinids and ornamen- (contact between a live fish and a dead fish, or with tal fishes, as well as marine fishes including gadids, free-living parasites present in the substrate, or with pleuronectids and gobiids. -
Benznidazole(Rinn)
830 Antiprotozoals Uses and Administration in endemic areas. It may also be used for prophylaxis in non- Neth.: Wellvone; Port.: Wellvone; S.Afr.: Wellvone; Spain: Wellvone; Atovaquone is a hydroxynaphthoquinone antiprotozo- immune travellers9,10 and appears to be well tolerated.10,11 Swed.: Wellvone; Switz.: Wellvone; UK: Wellvone; USA: Mepron. 1. Chiodini PL, et al. Evaluation of atovaquone in the treatment of Multi-ingredient: Austral.: Malarone; Austria: Malarone; Promal; Belg.: al that is also active against the fungus Pneumocystis patients with uncomplicated Plasmodium falciparum malaria. J Malarone; Canad.: Malarone; Cz.: Malarone; Denm.: Malarone; Fr.: Ma- jirovecii. It is used in the treatment and prophylaxis of Antimicrob Chemother 1995; 36; 1073–5. larone; Ger.: Malarone; Gr.: Malarone; Hong Kong: Malarone; Hung.: Ma- larone; Irl.: Malarone; Israel: Malarone; Ital.: Malarone; Malaysia: Malar- pneumocystis pneumonia in patients unable to tolerate 2. Looareesuwan S, et al. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of one; Neth.: Malarone; Norw.: Malarone; NZ: Malarone; Pol.: Malarone; co-trimoxazole, and with proguanil in the treatment acute uncomplicated malaria in Thailand. Am J Trop Med Hyg S.Afr.: Malanil; Singapore: Malarone; Spain: Malarone; Swed.: Malarone; Switz.: Malarone; UK: Malarone; USA: Malarone. and prophylaxis of malaria. 1996; 54: 62–6. 3. Radloff PD, et al. Atovaquone and proguanil for Plasmodium In the treatment of mild to moderate pneumocystis falciparum malaria. Lancet 1996; 347: 1511–14. pneumonia, atovaquone is given orally in a dose of 4. Sabchareon A, et al. Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrug-resistant Azanidazole (BAN, USAN, rINN) 750 mg with food twice daily as a suspension, for 21 Plasmodium falciparum malaria. -
Product List March 2019 - Page 1 of 53
Wessex has been sourcing and supplying active substances to medicine manufacturers since its incorporation in 1994. We supply from known, trusted partners working to full cGMP and with full regulatory support. Please contact us for details of the following products. Product CAS No. ( R)-2-Methyl-CBS-oxazaborolidine 112022-83-0 (-) (1R) Menthyl Chloroformate 14602-86-9 (+)-Sotalol Hydrochloride 959-24-0 (2R)-2-[(4-Ethyl-2, 3-dioxopiperazinyl) carbonylamino]-2-phenylacetic 63422-71-9 acid (2R)-2-[(4-Ethyl-2-3-dioxopiperazinyl) carbonylamino]-2-(4- 62893-24-7 hydroxyphenyl) acetic acid (r)-(+)-α-Lipoic Acid 1200-22-2 (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 207557-35-5 1,1'-Carbonyl diimidazole 530-62-1 1,3-Cyclohexanedione 504-02-9 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol acetate 839705-03-2 1-[2-Amino-1-(4-methoxyphenyl) ethyl] cyclohexanol Hydrochloride 130198-05-9 1-[Cyano-(4-methoxyphenyl) methyl] cyclohexanol 93413-76-4 1-Chloroethyl-4-nitrophenyl carbonate 101623-69-2 2-(2-Aminothiazol-4-yl) acetic acid Hydrochloride 66659-20-9 2-(4-Nitrophenyl)ethanamine Hydrochloride 29968-78-3 2,4 Dichlorobenzyl Alcohol (2,4 DCBA) 1777-82-8 2,6-Dichlorophenol 87-65-0 2.6 Diamino Pyridine 136-40-3 2-Aminoheptane Sulfate 6411-75-2 2-Ethylhexanoyl Chloride 760-67-8 2-Ethylhexyl Chloroformate 24468-13-1 2-Isopropyl-4-(N-methylaminomethyl) thiazole Hydrochloride 908591-25-3 4,4,4-Trifluoro-1-(4-methylphenyl)-1,3-butane dione 720-94-5 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine Hydrochloride 28783-41-7 4-Chloro-N-methyl-piperidine 5570-77-4 -
Slang Terms and Code Words: a Reference for Law Enforcement
UNCLASSIFIED Slang Terms and Code Words: A Reference for Law DEA Enforcement Personnel Intelligence DEA-HOU-DIR-022-18 July 2018 ReportBrief 1 UNCLASSIFIED UNCLASSIFIED DEA Intelligence Report Executive Summary This Drug Enforcement Administration (DEA) Intelligence Report contains new and updated information on slang terms and code words from a variety of law enforcement and open sources, and serves as an updated version to the product entitled “Drug Slang Code Words” published by the DEA in May 2017. It is designed as a ready reference for law enforcement personnel who are confronted with hundreds of slang terms and code words used to identify a wide variety of controlled substances, designer drugs, synthetic compounds, measurements, locations, weapons, and other miscellaneous terms relevant to the drug trade. Although every effort was made to ensure the accuracy and completeness of the information presented, due to the dynamics of the ever-changing drug scene, subsequent additions, deletions, and corrections are inevitable. Future addendums and updates to this report will attempt to capture changed terminology to the furthest extent possible. This compendium of slang terms and code words is alphabetically ordered, with new additions presented in italic text, and identifies drugs and drug categories in English and foreign language derivations. Drug Slang Terms and Code Wordsa Acetaminophen and Oxycodone Combination (Percocet®) 512s; Bananas; Blue; Blue Dynamite; Blueberries; Buttons; Ercs; Greenies; Hillbilly Heroin; Kickers; M-30s; -
Penguin Zoo to You
Penguin Zoo to You Thank you for inviting Omaha’s Henry Doorly ® Trunk Zoo & Aquarium into your classroom. We hope our PENGUINS Educator Trunk is relevant to your course of study and that we have provided a valuable teaching tool for you and your students. In the trunk you will find a variety of items which can be used to enrich your study of science, math, reading, and more. PENGUIN TRUNK CHECK-LIST (1) Penguins: Below the Equator Curriculum Binder (1) Penguins: Below the Equator CD (4)Replica Eggs (1) Container of Penguin Feathers (1) Flight Feathers (21) African Penguin Photos (1) Reading Safari Magazine (17) Mini Laminated Penguins (5) Penguin Identification Bands (15) Penguin Playing Card Sets (7) Life-size Penguins (2) Life-size Penguin Chicks (1) World Map BOOKS VIDEOS Humboldt Tails IMAX- Survival Island Penguin Pete IMAX- Antarctica Patti Pelican and the Gulf Oil Spill March of the Penguins The Little Penguin City Slickers- a Tale of Two A Mother’s Journey African Penguins The Emperor’s Egg SANCCOB- Treasure Oil Spill 2000 The Penguin Family (3 min 30 sec clip) Tacky in Trouble Penguins 1,2,3 The Penguin Baby Penguin © 2012 Omaha’s Henry Doorly Zoo & Aquarium® 1 Table of Contents Penguin Trunk Check List ......................................................................................1 Acknowledgments .................................................................................................3 Birds of a Feather ..................................................................................................4 Why Do -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
1471-2148-10-132.Pdf
Shen et al. BMC Evolutionary Biology 2010, 10:132 http://www.biomedcentral.com/1471-2148/10/132 RESEARCH ARTICLE Open Access AResearch mitogenomic article perspective on the ancient, rapid radiation in the Galliformes with an emphasis on the Phasianidae Yong-Yi Shen1,2,3, Lu Liang1,2,3, Yan-Bo Sun1,2,3, Bi-Song Yue4, Xiao-Jun Yang1, Robert W Murphy1,5 and Ya- Ping Zhang*1,2 Abstract Background: The Galliformes is a well-known and widely distributed Order in Aves. The phylogenetic relationships of galliform birds, especially the turkeys, grouse, chickens, quails, and pheasants, have been studied intensively, likely because of their close association with humans. Despite extensive studies, convergent morphological evolution and rapid radiation have resulted in conflicting hypotheses of phylogenetic relationships. Many internal nodes have remained ambiguous. Results: We analyzed the complete mitochondrial (mt) genomes from 34 galliform species, including 14 new mt genomes and 20 published mt genomes, and obtained a single, robust tree. Most of the internal branches were relatively short and the terminal branches long suggesting an ancient, rapid radiation. The Megapodiidae formed the sister group to all other galliforms, followed in sequence by the Cracidae, Odontophoridae and Numididae. The remaining clade included the Phasianidae, Tetraonidae and Meleagrididae. The genus Arborophila was the sister group of the remaining taxa followed by Polyplectron. This was followed by two major clades: ((((Gallus, Bambusicola) Francolinus) (Coturnix, Alectoris)) Pavo) and (((((((Chrysolophus, Phasianus) Lophura) Syrmaticus) Perdix) Pucrasia) (Meleagris, Bonasa)) ((Lophophorus, Tetraophasis) Tragopan))). Conclusions: The traditional hypothesis of monophyletic lineages of pheasants, partridges, peafowls and tragopans was not supported in this study. -
Nitrofurazone
PATIENT INFORMATION SHEET Nitrofurazone (N-005) Your patch testing results indicate that you have a contact allergy to Nitrofurazone . It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. i What is Nitrofurazone and where is it found? This chemical is used as a topical bactericide for surface infections. If is also used in anti ‐infective therapy for second and third degree burns and in skin grafting. It is also an antibacterial agent for the treatment or prevention of infections in a variety of conditions involving skin, eyes, ears, nose and genitourinary tract. It is used on pyodermas, ulcers and wounds. Further research may identify additional product or industrial usages of this chemical. i What else is Nitrofurazone called? This chemical can be identified by different names, including: 2‐[(5 ‐Nitro ‐2‐furanyl)methylene]‐hydrazinecarboxamide 5‐nitro ‐2‐furfuraldehyde semicarbazone (5 ‐nitro ‐2‐furfurylideneamino)urea 5‐nitrofurfural semicarbazone 5‐Nitro ‐2‐furaldehyde Semicarbazone 6‐nitrofuraldehyde semicarbazide 5‐nitrofuraldehyde semicarbazide NF 5‐nitrofuran ‐2‐aldehyde semicarbazone NF ‐7 5‐nitro ‐2‐furancarboxaldehyde semicarbazone NFS This may not be a complete list as manufacturers introduce and delete chemicals from their product lines. THINGS YOU CAN DO TO HELP MANAGE YOUR CONTACT ALLERGY Be vigilant read the product label. Always take the time to read the ingredient listing on product packages. This should be your first step each time you purchase a product as manufacturers sometimes change product ingredients. If you have any concerns ask your pharmacist or your doctor. Test the product first. -
NINDS Custom Collection II
ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC -
Control of Intestinal Protozoa in Dogs and Cats
Control of Intestinal Protozoa 6 in Dogs and Cats ESCCAP Guideline 06 Second Edition – February 2018 1 ESCCAP Malvern Hills Science Park, Geraldine Road, Malvern, Worcestershire, WR14 3SZ, United Kingdom First Edition Published by ESCCAP in August 2011 Second Edition Published in February 2018 © ESCCAP 2018 All rights reserved This publication is made available subject to the condition that any redistribution or reproduction of part or all of the contents in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise is with the prior written permission of ESCCAP. This publication may only be distributed in the covers in which it is first published unless with the prior written permission of ESCCAP. A catalogue record for this publication is available from the British Library. ISBN: 978-1-907259-53-1 2 TABLE OF CONTENTS INTRODUCTION 4 1: CONSIDERATION OF PET HEALTH AND LIFESTYLE FACTORS 5 2: LIFELONG CONTROL OF MAJOR INTESTINAL PROTOZOA 6 2.1 Giardia duodenalis 6 2.2 Feline Tritrichomonas foetus (syn. T. blagburni) 8 2.3 Cystoisospora (syn. Isospora) spp. 9 2.4 Cryptosporidium spp. 11 2.5 Toxoplasma gondii 12 2.6 Neospora caninum 14 2.7 Hammondia spp. 16 2.8 Sarcocystis spp. 17 3: ENVIRONMENTAL CONTROL OF PARASITE TRANSMISSION 18 4: OWNER CONSIDERATIONS IN PREVENTING ZOONOTIC DISEASES 19 5: STAFF, PET OWNER AND COMMUNITY EDUCATION 19 APPENDIX 1 – BACKGROUND 20 APPENDIX 2 – GLOSSARY 21 FIGURES Figure 1: Toxoplasma gondii life cycle 12 Figure 2: Neospora caninum life cycle 14 TABLES Table 1: Characteristics of apicomplexan oocysts found in the faeces of dogs and cats 10 Control of Intestinal Protozoa 6 in Dogs and Cats ESCCAP Guideline 06 Second Edition – February 2018 3 INTRODUCTION A wide range of intestinal protozoa commonly infect dogs and cats throughout Europe; with a few exceptions there seem to be no limitations in geographical distribution.