RHODIOLA Rhodiola rosea L. (Sedum roseum L. Scop) EFFICACY AND USES Rhodiola (Rhodiola rosea or Sedum roseum. The name “golden root” was given because of the “exquisite Family: Crassulaceae), known as roseroot, rosenroot, pharmacological properes of the root compounds” and the golden root, arcc root, orpin rose, is a popular herb common name “rose root” because of the rose scent that comes used in tradional medicine in Europe and Asia.1, 6, 7, 9, 14 from freshly sliced roots; while the name “arcc root” is based on the geographic distribuon of this species across the Arcc 7-9 The main compounds of Rhodiola roots and region. rhizomes include certain phenylpropanoids, namely the cinnamyl alcohol glycosides rosin, rosarin, and rosavin, Euromed´s quality collecvely referred to as rosavins, and the control process phenylethanoid compound salidroside (or PhytoProof™ ensures a rhodioloside) with its aglycone tyrosol. Extracts premium extract with commonly standardized to both rosavins and salidroside, full traceability. in a 3:1 rao have been used medicinally for more than 30 years within the European Union.1, 7, 14 Euromed´s Rhodiola extract contains. Rosavins: >3% Salidroside: >1%

Adaptogens are natural compounds or plant extracts that safely increase adaptability and survival of living organisms to stress through a mulstep physiological process including diverse mechanisms of extracellular and intracellular interacons. As an adaptogen, R. rosea increases non specific resistance to stress and may have beneficial effects on physical performance, the immune system, mental performance and mood, enhancing well- being and supporng healthy ageing.1, 2, 9 These effects are mediated by a broad spectrum of acons shown in a wide variety or preclinical and clinical studies evaluang stress-reducing properes, and modulaon of physical and psychological funcon.1

EVIDANCE-BASED BENEFITS • Improvement of mental capacity, learning and memory funcon, aenon, task performance, retrieval process and overall mood, reducon of stress-related anxiety. (Cropley et al. 2015; Edwards et al. 2012)

• Enhancement of physical performance and alleviaon of mental fague. (Ishaque et al. BMC Complentary and Alternave Medicine 2012, 12:7)

• Improved resilience and prevenon of exhauson under increased workload (Darbinyan et al. 2000) 1-3 This material is intended for professionals only. www.euromed.es RHODIOLA Rhodiola rosea L. (Sedum roseum L. Scop) EFFICACY AND USES RHODIOLA POSITIVELY MODULATES THE HOMEOSTASIS OF MULTIPLE PHYSIOLOGICAL FUNCTIONS

Rhodiola shows adaptogenic properes parcularly in the case of stress related decreased performance with symptoms such as fague, sensaon of weakness, irritability and mild anxiety.

Cerebral effects Rhodiola increases brain levels of neurotransmiers such as nor-epinephrine, serotonin, acetylcholine and dopamine. Adaptogenic and neurological effects may be explained with modulaon of neurotransmier levels, brain plascity and corcal excitability.4, 3, 10, 12

Physical work performance Rhodiola produces ergogenic benefits and enhances endurance performance by means of increasing resistance to exhauson and a variety of components associated with oxygen uptake.8, 11, 13

Mental work performance The mild smulant and non-addicve properes of Rhodiola on the Central Nervous System facilitate improved mood and cognive funcons including memory, learning and aenon, especially under fague and stress condions.2,4, 12, 15

Ageing Salidroside is considered a pleiotropic compound, that interacts with different molecular pathways and physiological funcons of interest for neuroprotecve and cardioprotecve properes in age-related health condions.5, 11, 12, 13, 15

It has been suggested that inhibion of ageing-induced increased generaon of leukotrienes in brain cells by adaptogens like Rhodiola may contribute to their potenally beneficial mental health effects. It is known that adaptogens smulate cellular and organism defense systems by acvang intracellular and extracellular signalling pathways and expression of stress-acvated proteins and neuropepdes (regulaon of adapve stress response and adapve stress-response signalling pathways or ASRSPs). Rhodiola supports modulaon of the immune response and reparaon from oxidave stress, reducing stress-vulnerability and supporng resiliency.2,5 As for all Euromed extracts, with Rhodiola Euromed controls each step of the supply chain, from sustainable harvesng to pharmacopoeial grade phytochemical profiling, as defined in our Euromed Traceability Circle of Excellence. Each producon batch, from the herb to the final extract, is subjected to a several laboratory tests for identy, potency and potenal impuries. These comprehensive tests are part of the PhytoProof® process of quality control and, when recorded on its cerficates of analyses, are assurance that the extract batch was manufactured correctly.

Commonly recommend dosage is 100–150 mg/day, gradually increased to 600 mg/day.

REFERENCES 1 EMA/HMPC/232100/2011; 2 Panossian A. G. et. al. Med Res Rev. 2020; 1-74; 3 Moragrega I et. al. Planta Med 2021 10.1055/a-1338-1011, 0032-0943; 4 Akhtar Q N et. al. Neuropsychiatr. Dis. Treat. 2013:9 639-658; 5 Ghosh Dilip, Nutraceucals in Brain Health and Beyond, 2021; 6 Ghiorghita G et. al. 2015 Biol, veget., 61, 1-2: 5-25; 7 Amsterdam J. D. et. al. Phytomedicine 23 2016 770-783; 8 Panossian A. et. al. Phytomedicine 17 2010 481-493; 9 Cuerrier A et. al. Rhodiola rosea 2015 TYF Group, LLC; 10 Anghelescu IG. et al. Int J Psychiatry Clin Pract 10. 1080/13651501. 2017. 1417442; 11 Chen P et al. Sci Rep 2019; 2 (1): 18127; 12 Fan F. et. al. Biomed Pharmacother 2020; 129: 110458; 13 Sun S et al. Evid Based Complement Alternat Med 2020; 2020: 9568647; 14 Tao H et al. Med Res Rev 2019; 39 (5): 1779-1850; 15 Li Q et al. Cell Mol Neurobiol 2020; 40 (7): 1133-1142; 2-3 This material is intended for professionals only. www.euromed.es