Bts Guideline for Oxygen Use in Adults in Healthcare And
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Hypoxia Signaling in Cardiovascular Diseases
DOI: 10.5772/intechopen.80456 ProvisionalChapter chapter 3 Hypoxia Signaling in Cardiovascular Diseases NehaNeha Gupta Gupta and Mohammad Zahid AshrafZahid Ashraf Additional information is available at the end of the chapter http://dx.doi.org/10.5772/intechopen.80456 Abstract Cardiovascular diseases such as stroke, coronary artery disease, and thrombosis remain a global health burden. Understanding the mechanism of these diseases paves the way for development of prophylactics/therapeutics. It is well known at cellular levels; the patho- physiology of most of the cardiovascular disease involves a complicated yet coordinated signaling networks triggered in response to either cellular or tissue levels of hypoxic milieu. Information related to types of hypoxia and signaling mechanism associated to such complications if complied and presented in a comprehensive manner shall prove relevant in proposing common therapeutic targets for wide array of cardiovascular com- plications. The relative functional roles of hypoxia-triggered signaling pathways are also an area of current research. Based upon these facts, this chapter discusses the types of hypoxia and role of hypoxia-mediated signaling pathways in various types of commonly occurring cardiovascular disorders. Keywords: hypoxia, signaling, cardiovascular disorders, thrombosis, therapeutics 1. Introduction Oxygen concentration below the tissue specific physiological levels is termed as ‘Hypoxia’. Depending upon the cause of oxygen scarcity, hypoxia can be classified into Hypoxic hypoxia (occurs due to deficiency in oxygen exchange in lungs or arises due to reduced partial pres- sure of oxygen in air), Anemic hypoxia (arises when the transport of oxygen is affected), stagnant hypoxia (due to delayed blood renewal, or insufficient blood flow) or histotoxic hypoxia (body is not able to use the available oxygen) [1]. -
SIGN158 British Guideline on the Management of Asthma
SIGN158 British guideline on the management of asthma A national clinical guideline First published 2003 Revised edition published July 2019 Key to evidence statements and recommendations Levels of evidence 1++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1+ Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1– Meta-analyses, systematic reviews, or RCTs with a high risk of bias 2++ High-quality systematic reviews of case-control or cohort studies High-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal 2+ Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal 2– Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal 3 Non-analytic studies, eg case reports, case series 4 Expert opinion Grades of recommendation Note: The grade of recommendation relates to the strength of the supporting evidence on which the evidence is based. It does not reflect the clinical importance of the recommendation. A At least one meta-analysis, systematic review, or RCT rated as 1++, and directly applicable to the target population; or A body of evidence consisting principally of studies rated as 1+, directly applicable to the target population, and demonstrating overall consistency of results B A body of evidence including studies rated -
The Use of Heliox in Treating Decompression Illness
The Diving Medical Advisory Committee DMAC, Eighth Floor, 52 Grosvenor Gardens, London SW1W 0AU, UK www.dmac-diving.org Tel: +44 (0) 20 7824 5520 [email protected] The Use of Heliox in Treating Decompression Illness DMAC 23 Rev. 1 – June 2014 Supersedes DMAC 23, which is now withdrawn There are many ways of treating decompression illness (DCI) at increased pressure. In the past 20 years, much has been published on the use of oxygen and helium/oxygen mixtures at different depths. There is, however, a paucity of carefully designed scientific studies. Most information is available from mathematical models, animal experiments and case reports. During a therapeutic compression, the use of a different inert gas from that breathed during the dive may facilitate bubble resolution. Gas diffusivity and solubility in blood and tissue is expected to play a complex role in bubble growth and shrinkage. Mathematical models, supported by some animal studies, suggest that breathing a heliox gas mixture during recompression could be beneficial for nitrogen elimination after air dives. In humans, diving to 50 msw, with air or nitrox, almost all cases of DCI can be adequately treated at 2.8 bar (18 msw), where 100% oxygen is both safe and effective. Serious neurological and vestibular DCI with only partial improvements during initial compression at 18 msw on oxygen may benefit from further recompression to 30 msw with heliox 50:50 (Comex therapeutic table 30 – CX30). There have been cases successfully treated on 50:50 heliox (CX30), on the US Navy recompression tables with 80:20 and 60:40 heliox (USN treatment table 6A) instead of air and in heliox saturation. -
Approach to Cyanosis in a Neonate.Pdf
PedsCases Podcast Scripts This podcast can be accessed at www.pedscases.com, Apple Podcasting, Spotify, or your favourite podcasting app. Approach to Cyanosis in a Neonate Developed by Michelle Fric and Dr. Georgeta Apostol for PedsCases.com. June 29, 2020 Introduction Hello, and welcome to this pedscases podcast on an approach to cyanosis in a neonate. My name is Michelle Fric and I am a fourth-year medical student at the University of Alberta. This podcast was made in collaboration with Dr. Georgeta Apostol, a general pediatrician at the Royal Alexandra Hospital Pediatrics Clinic in Edmonton, Alberta. Cyanosis refers to a bluish discoloration of the skin or mucous membranes and is a common finding in newborns. It is a clinical manifestation of the desaturation of arterial or capillary blood and may indicate serious hemodynamic instability. It is important to have an approach to cyanosis, as it can be your only sign of a life-threatening illness. The goal of this podcast is to develop this approach to a cyanotic newborn with a focus on these can’t miss diagnoses. After listening to this podcast, the learner should be able to: 1. Define cyanosis 2. Assess and recognize a cyanotic infant 3. Develop a differential diagnosis 4. Identify immediate investigations and management for a cyanotic infant Background Cyanosis can be further broken down into peripheral and central cyanosis. It is important to distinguish these as it can help you to formulate a differential diagnosis and identify cases that are life-threatening. Peripheral cyanosis affects the distal extremities resulting in blue color of the hands and feet, while the rest of the body remains pinkish and well perfused. -
A Professional Development Framework for Paediatric Respiratory Nursing
A professional development framework for paediatric respiratory nursing ISSN 2040-2023: British Thoracic Society Reports Vol 12, Issue 2, May 2021 1 ACKNOWLEDGEMENTS: We are grateful to colleagues at the National Paediatric Respiratory and Allergy Nurses Group (NPRANG) for their support with the development of this document. In particular: Ann McMurray Asthma Nurse Specialist, Royal Hospital for Children and Young People, Edinburgh. NPRANG Chair Bethan Almeida Clinical Nurse Specialist for Paediatric Asthma and Allergy, Imperial College Healthcare NHS Trust Tricia McGinnity Paediatric Cystic Fibrosis Nurse Specialist, Southampton Children's Hospital Emma Bushell Paediatric Respiratory Nurse Specialist – Asthma, Frimley Health NHS Foundation Trust This document has been adapted from the following publication: British Thoracic Society, A professional development framework for respiratory nursing (1). The authors of this original document are: Samantha Prigmore, Co-chair Consultant respiratory nurse, St Georges University Hospitals NHS Foundation Trust Helen Morris, Co-chair ILD nurse specialist, Wythenshawe Hospital Alison Armstrong Nurse consultant (assisted ventilation), Royal Victoria Infirmary Susan Hope Respiratory nurse specialist, Royal Stoke University Hospital Karen Heslop-Marshall Nurse consultant, Royal Victoria Infirmary Jacqui Pollington Respiratory nurse consultant, Rotherham NHS Foundation Trust CONTENTS: Introduction Method of production How to use this document Competency table (Band 5, 6, 7 and 8) Supporting evidence Acknowledgements Declarations of Interest References Content from this document may be reproduced with permission from BTS as long as you conform to the following conditions: • The text must not be altered in any way. • The correct acknowledgement must be included. 2 Introduction Paediatric respiratory nurses are an important component of the multi-professional team for a wide variety of respiratory conditions, providing holistic care for patients in a variety of settings. -
Review of Systems
code: GF004 REVIEW OF SYSTEMS First Name Middle Name / MI Last Name Check the box if you are currently experiencing any of the following : General Skin Respiratory Arthritis/Rheumatism Abnormal Pigmentation Any Lung Troubles Back Pain (recurrent) Boils Asthma or Wheezing Bone Fracture Brittle Nails Bronchitis Cancer Dry Skin Chronic or Frequent Cough Diabetes Eczema Difficulty Breathing Foot Pain Frequent infections Pleurisy or Pneumonia Gout Hair/Nail changes Spitting up Blood Headaches/Migraines Hives Trouble Breathing Joint Injury Itching URI (Cold) Now Memory Loss Jaundice None Muscle Weakness Psoriasis Numbness/Tingling Rash Obesity Skin Disease Osteoporosis None Rheumatic Fever Weight Gain/Loss None Cardiovascular Gastrointestinal Eyes - Ears - Nose - Throat/Mouth Awakening in the night smothering Abdominal Pain Blurring Chest Pain or Angina Appetite Changes Double Vision Congestive Heart Failure Black Stools Eye Disease or Injury Cyanosis (blue skin) Bleeding with Bowel Movements Eye Pain/Discharge Difficulty walking two blocks Blood in Vomit Glasses Edema/Swelling of Hands, Feet or Ankles Chrohn’s Disease/Colitis Glaucoma Heart Attacks Constipation Itchy Eyes Heart Murmur Cramping or pain in the Abdomen Vision changes Heart Trouble Difficulty Swallowing Ear Disease High Blood Pressure Diverticulosis Ear Infections Irregular Heartbeat Frequent Diarrhea Ears ringing Pain in legs Gallbladder Disease Hearing problems Palpitations Gas/Bloating Impaired Hearing Poor Circulation Heartburn or Indigestion Chronic Sinus Trouble Shortness -
17Th & 18Th June 2021 Speakers' Details and Presentation Summaries
th th SUMMER MEETING ONLINE – 17 & 18 June 2021 Speakers’ Details and Presentation Summaries The following details are in programme order. Use the PDF search button to quickly find a session or speaker. OPEN SESSION – NATIONAL ASTHMA AND COPD AUDIT PROGRAMME Thursday 17th June: 08:00-09:00 Dr James Calvert qualified in Medicine from Oxford Session aims and overview University in 1992. He studied Public Health as a 1) To summarise the main findings of the 2020/21 Fulbright Scholar at Harvard University before NACAP reports. completing his PhD in Asthma Epidemiology in South 2) To outline the QI support opportunities offered by Africa and London. NACAP to clinical and audit teams. He was a Consultant Respiratory Specialist in Bristol from 2006-2021. He is now a Respiratory Consultant Professor Roberts will present a summary of key and Medical Director of Aneurin Bevan University reported findings from across the audits from the last Health Board in Wales. 12 months, highlighting areas for further James has worked with colleagues in the South West improvement. He will speak about the impact of and at NHS England to improve access to integrated COVID-19 on standards of care and on audit services for respiratory patients. He has Chaired the participation, along with plans to improve automated British Thoracic Society (BTS) Professional and extraction of NACAP data. Organisational Standards Committee and has been Dr Calvert will talk about the QI programme to be the BTS National Audit Lead. He has a longstanding launched this year. interest in quality improvement in health care and has A discussion will follow around ideas for improving worked with the BTS, NHS Improving Value, the Royal NACAP support to clinical and audit teams. -
A Bibliometric Analysis
787 Original Article Page 1 of 9 The 100 most cited articles on lung cancer screening: a bibliometric analysis Meng Li1,2, Qiang Cai2,3, Jing-Wen Ma1, Li Zhang1,2, Claudia I. Henschke2 1Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 2Department of Radiology, Mount Sinai Health System, New York, NY, USA; 3Department of Radiology, Shanxi Provincial People’s Hospital, Taiyuan, China Contributions: (I) Conception and design: M Li, CI Henschke; (II) Administrative support: CI Henschke; (III) Provision of study materials or patients: M Li, CI Henschke; (IV) Collection and assembly of data: M Li, L Zhang; (V) Data analysis and interpretation: M Li, Q Cai, JW Ma; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Claudia I. Henschke. Department of Radiology, Mount Sinai Health System, 1 Gustave Levy Place, New York, NY 10029, USA. Email: [email protected]. Background: The number of citations of an article reflects its impact on the scientific community. The aim of this study was to identify and characterize the 100 most cited articles on lung cancer screening. Methods: The 100 most cited articles on lung cancer screening published in all scientific journals were identified using the Web of Science database. Relevant data, including the number of citations, publication year, publishing journal and impact factor (IF), authorship and country of origin, article type and study design, screening modality, and main topic, were collected and analyzed. Results: The 100 most cited articles were all English and published between 1973 and 2017, with 81 published after 2000. -
BTS Guideline for Oxygen Use in Adults in Healthcare and Emergency
BTS guideline BTS guideline for oxygen use in adults in healthcare Thorax: first published as 10.1136/thoraxjnl-2016-209729 on 15 May 2017. Downloaded from and emergency settings BRO’Driscoll,1,2 L S Howard,3 J Earis,4 V Mak,5 on behalf of the British Thoracic Society Emergency Oxygen Guideline Group ▸ Additional material is EXECUTIVE SUMMARY OF THE GUIDELINE appropriate oxygen therapy can be started in the published online only. To view Philosophy of the guideline event of unexpected clinical deterioration with please visit the journal online ▸ (http://dx.doi.org/10.1136/ Oxygen is a treatment for hypoxaemia, not hypoxaemia and also to ensure that the oxim- thoraxjnl-2016-209729). breathlessness. Oxygen has not been proven to etry section of the early warning score (EWS) 1 have any consistent effect on the sensation of can be scored appropriately. Respiratory Medicine, Salford ▸ Royal Foundation NHS Trust, breathlessness in non-hypoxaemic patients. The target saturation should be written (or Salford, UK ▸ The essence of this guideline can be summarised ringed) on the drug chart or entered in an elec- 2Manchester Academic Health simply as a requirement for oxygen to be prescribed tronic prescribing system (guidance on figure 1 Sciences Centre (MAHSC), according to a target saturation range and for those (chart 1)). Manchester, UK 3Hammersmith Hospital, who administer oxygen therapy to monitor the Imperial College Healthcare patient and keep within the target saturation range. 3 Oxygen administration NHS Trust, London, UK ▸ The guideline recommends aiming to achieve ▸ Oxygen should be administered by staff who are 4 University of Liverpool, normal or near-normal oxygen saturation for all trained in oxygen administration. -
Clinical Management of Severe Acute Respiratory Infections When Novel Coronavirus Is Suspected: What to Do and What Not to Do
INTERIM GUIDANCE DOCUMENT Clinical management of severe acute respiratory infections when novel coronavirus is suspected: What to do and what not to do Introduction 2 Section 1. Early recognition and management 3 Section 2. Management of severe respiratory distress, hypoxemia and ARDS 6 Section 3. Management of septic shock 8 Section 4. Prevention of complications 9 References 10 Acknowledgements 12 Introduction The emergence of novel coronavirus in 2012 (see http://www.who.int/csr/disease/coronavirus_infections/en/index. html for the latest updates) has presented challenges for clinical management. Pneumonia has been the most common clinical presentation; five patients developed Acute Respira- tory Distress Syndrome (ARDS). Renal failure, pericarditis and disseminated intravascular coagulation (DIC) have also occurred. Our knowledge of the clinical features of coronavirus infection is limited and no virus-specific preven- tion or treatment (e.g. vaccine or antiviral drugs) is available. Thus, this interim guidance document aims to help clinicians with supportive management of patients who have acute respiratory failure and septic shock as a consequence of severe infection. Because other complications have been seen (renal failure, pericarditis, DIC, as above) clinicians should monitor for the development of these and other complications of severe infection and treat them according to local management guidelines. As all confirmed cases reported to date have occurred in adults, this document focuses on the care of adolescents and adults. Paediatric considerations will be added later. This document will be updated as more information becomes available and after the revised Surviving Sepsis Campaign Guidelines are published later this year (1). This document is for clinicians taking care of critically ill patients with severe acute respiratory infec- tion (SARI). -
Value of Pulse Oximetry in Screening for Long-Term Oxygen Therapy Requirement
Copyright CERS Journals Ltd 1993 Eur Reaplr J, 1993, 6, 559-562 European Respiratory Journal Printed In UK • all rlghta reaerved ISSN 0903 • 1936 TECHNICAL NOTE Value of pulse oximetry In screening for long-term oxygen therapy requirement C.M. Roberts, J.R. Bugler, R. Melchor, M.R. Hetzel, S.G. Spire Value of pulse oximetry in screening for long-term oxygen therapy requirement. C.M. Dept of Thoracic Medicine, University Roberts, J.R. Bugler, R. Melcltor, M.R. Hetzel, S.G. Spiro. aRS Journals Ltd 1993. College Hospital, Gower Street, London, ABSTRACT: Pulse oximetry, combined with spirometry, was evaluated as a method UK. of selecting chronic obstructive pulmonary disease (COPD) out-patients requiring definitive arterial blood gas analysis for long-term oxygen therapy (LTO'I} assess· Correspondence: C.M. Roberts The Chest Clinic ment. A relatively blgb screening arterial oxygen saturation by pulse oximetry Whipps Cross Hospital (Sao ) level was set, In order to maximize sensitivity. London Ell Ail 113 COPD out-patients att.endlng the hospital clinic over a 6 month period UK wet-e screened. Sixty bad a forced expiratory volume In one second d.S I and 26 Keywords: Chronic obstructive pulmonary bad an Sao1 s92 %. These 26 underwent arterial blood gas analysis. Nine had an ) disease arterial oxygen tension <7 .3 kPa all with an arterial carbon dioxide tension (Paco1 >6 kPa. A further eight had a Pao <8 kPa. This produced a sensitivity or 100% hypoxaemia and speclftclty or 69% for oximetry fn the detectl.on of Pao <7.3 kPa detenn.lned by oxygen therapy 1 pulse oximetry direct arterial puncture and 100% and 86% respectively for detecting a Pao1 <8 kPa. -
Chest Pain in Pediatrics
PEDIATRIC CARDIOLOGY 0031-3955/99 $8.00 + .OO CHEST PAIN IN PEDIATRICS Keith C. Kocis, MD, MS Chest pain is an alarming complaint in children, leading an often frightened and concerned family to a pediatrician or emergency room and commonly to a subsequent referral to a pediatric cardiologist. Because of the well-known associ- ation of chest pain with significant cardiovascular disease and sudden death in adult patients, medical personnel commonly share heightened concerns over pediatric patients presenting with chest pain. Although the differential diagnosis of chest pain is exhaustive, chest pain in children is least likely to be cardiac in origin. Organ systems responsible for causing chest pain in children include*: Idiopathic (12%-85%) Musculoskeletal (15%-31%) Pulmonary (12%-21%) Other (4%-21%) Psychiatric (5%-17%) Gastrointestinal (4'/0-7%) Cardiac (4%4%) Furthermore, chest pain in the pediatric population is rareZy associated with life-threatening disease; however, when present, prompt recognition, diagnostic evaluation, and intervention are necessary to prevent an adverse outcome. This article presents a comprehensive list of differential diagnostic possibilities of chest pain in pediatric patients, discusses the common causes in further detail, and outlines a rational diagnostic evaluation and treatment plan. Chest pain, a common complaint of pediatric patients, is often idiopathic in etiology and commonly chronic in nature. In one study,67 chest pain accounted for 6 in 1000 visits to an urban pediatric emergency room. In addition, chest pain is the second most common reason for referral to pediatric cardiologist^.^, 23, 78 Chest pain is found equally in male and female patients, with an average *References 13, 17, 23, 27, 32, 35, 44, 48, 49, 63-67, 74, and 78.