Dehydration and Oral Rehydration Solutions Health Professional Training Guide

Hydralyte is suitable for the whole family

Replacing lost fluid and electrolytes with an oral rehydration solution (ORS) is the most important aspect of managing dehydration. Hydralyte is a scientifically formulated ORS based on the World Health Organization criteria for oral rehydration therapy. The solutions contain the correct balance of glucose and electrolytes to allow for rapid and effective rehydration. Fluid regulation in the body

Fluids and solutes, along with nutrients and waste products constantly shift within SIGNS AND SYMPTOMS How to manage dehydration the body’s compartments from cells to interstitial spaces, to blood vessels, and of dehydration: back again. Replacing lost fluid and electrolytes with an oral rehydration solution (ORS) is the most important aspect Increased thirst of managing dehydration. Hydralyte is a scientifically formulated ORS based on the World Health Water is moved as needed to keep the amount in each area relatively constant, Fatigue / Lethargy Organization criteria for oral rehydration therapy.1 The solutions contain the correct balance of glucose thus enabling the body to function optimally: Dizziness and electrolytes to allow for rapid and effective rehydration. When water loss is severe, the amount of water in the bloodstream decreases. The body moves water from inside the cells to outside the cells, and into the Headaches bloodstream until it can be replaced through increased fluid intake. Dark yellow urine, or decreased When the body has excess water, the amount in the bloodstream increases, urine output so the body moves water from the bloodstream into and around the cells. Sticky or dry mouth Hydralyte products This ensures blood volume and blood pressure can be kept relatively constant. Loss of skin elasticity Oral rehydration solutions Irritability (Hydralyte) – The science Oral Electrolyte Solution No error in mixing. Fluid imbalance The most important physiological features are: Convenient pre-made drink. 1. Correct balance of sodium and glucose leads to the To maintain a euhydrated state (optimal fluid balance) – water intake must equal Extended shelf life after activation of the sodium-glucose co-transporter in water loss. Fluid imbalance occurs when there is a: opening – bottles last up to A focus on the small intestinal lumen – this allows for rapid 1 month once open in the FLUID DEFICIT absorption. Sodium and glucose bind to the refrigerator. Ideal for families Active fluid loss: hemorrhage, diarrhea, excessive sweating. DEHYDRATION transporter protein – driven by high sodium with vomiting and diarrhea. concentrations in the small intestine. This dual Inadequate fluid intake: poor thirst mechanism, mobility issues (i.e. in seniors). Dehydration is the significant binding causes the transport protein to change shape, Regulatory mechanism failure: renal impairment, medical conditions (such as depletion of body water and delivering sodium and glucose to cell internals. diabetic ketoacidosis) and medications (such as diuretics). electrolytes. At the same time, water moves into the cell internals by osmosis. Effervescent Electrolyte Tablets FLUID SURPLUS Dehydration results from increased Sodium and glucose are both actively transported out Compact in size to fit in luggage for fluid loss, decreased fluid intake, traveling families, sports bags, Excess fluid intake (without electrolyte replacement). of the cell into the blood, along with water. or both. backpacks, and diaper bags for Regulatory mechanism failure, medical conditions (such as congestive heart failure). Small Cell Cell moms on the go. SodiumMild Glucose to moderate intestine dehydrationmembrane is internals Easy to use formulation – dissolve Fluid imbalance can be associated with: dehydration, hyponatremia, heat cramps, Transporter... commonly defined as 2–6% of 2 tablets in 7 fl oz of water – heat exhaustion and heat stroke. Na Na body weight loss through fluid. Na Na no stirring required!

Glu Glu Glu Glu Sodium Risk factors for dehydration Glucose

Vomiting & diarrhea Heavy sweating 2. The solution is hypotonic – this allows for effective Oral Electrolyte Powder Large loss of fluid and electrolytes. Heat exposure and vigorous physical exercise usually rehydration while minimizing potential side effects Easy to prepare format, FACT: Dehydration is the biggest health risk increases the sweat rate. such as unnecessary calories or a feeling of compact and portable for associated with vomiting and diarrhea. Fluid and electrolytes are commonly lost through sweat. fullness/bloating. travel and on the go. FACT: Prolonged heatwaves often put the health of children Packed with a measuring and seniors at risk of mild to moderate dehydration. It is important to know that water alone or sugary cup to allow for accurate dosing. drinks (i.e. soda or sports drinks) do not contain the Ideal for first aid kits. correct balance of sodium or glucose to allow for Travel Clinical conditions rapid hydration. Travelers’ diarrhea. Certain medical conditions and procedures can Hydralyte is Increased physical activity and exposure to the sun increase the risk of dehydration e.g. colonoscopies suitable for the (excess fluid and electrolyte loss through sweat). (due to bowel preparation procedures), chemotherapy and whole family radiotherapy, lack of food and fluid intake during periods of illness (such as fever), pregnancy related dehydration due to morning sickness or nausea (often leading to reduced food and fluid intake). 1 World Health Organization. Oral Rehydration Salts – Production of the new ORS. 2006. Available at: http://whqlibdoc.who.int/hq/2006/WHO_FCH_CAH_06.1.pdf

Dehydration and Oral Rehydration Solutions Dehydration and Oral Rehydration Solutions

2 | www.hydralyte.com Use under medical supervision Use under medical supervision www.hydralyte.com | 3 Ingredients Hydralyte formulation

Hydralyte electrolyte powder – Dextrose Ingredient Function Hydralyte per Sports drink (anhydrous), citric acid, sodium chloride, Liter (1.1 QT) (per Liter – potassium citrate, natural flavor (orange flavor), approximate natural and artificial flavor (berry flavor), sucralose, values) ß-carotene (orange flavor), grape skin extract Sodium Helps body to 45–60 mEq 12–23 mEq (berry flavor) retain fluid Hydralyte electrolyte solution – Water, Potassium Essential for nerve 20 mEq 4–9 mEq dextrose, citric acid, sodium chloride, potassium and muscle citrate, natural flavor, sucralose, sodium benzoate function & potassium sorbate (to prevent spoilage), Yellow Chloride Helps body to 35–45 mEq NA 6 (orange flavor), Red 40 & Blue 1 (berry flavor) retain fluid

Hydralyte effervescent electrolyte Primary Assists with 0.6 oz (glucose) 2.1–2.6 oz tablets – Dextrose (anhydrous), citric acid, sugar absorption of fluid (glucose/ fructose/ and electrolytes sucrose) sodium bicarbonate, maltose, potassium chloride, sodium chloride, natural flavor (orange flavor), Osmolality WHO recommendation 245 mOsm/L Variable – not natural and artificial flavor (berry flavor), mannitol, = 245 mOsm/L standardized polyethylene glycol 6000, sucralose, ß-carotene Calories 80 (powder, 260–320 (orange flavor), grape skin extract (berry flavor) per Liter solution) –110 (1.1 QT) (effervescent tablets)

FAQs for Health Care Professionals Is Hydralyte suitable to use in pregnancy and breastfeeding? Is Hydralyte suitable for people with diabetes? Yes, however, pregnant women should seek medical Hydralyte products contain up to 2 g of glucose per advice if they experience vomiting or diarrhea. 3.4 fl. oz. For people with diabetes, this is a small amount of glucose and is considered safe as part of Is Hydralyte fructose-friendly? a healthy, balanced overall diet. When unwell with Hydralyte does not contain any added fructose. vomiting and diarrhea, it is important to supply the However, the flavors in the product may contain minute body with some glucose, even for people with diabetes. quantities of fructose. If a patient suffers from dietary Monitoring of blood glucose levels at this time is integral. fructose intolerance (malabsorption), Hydralyte will generally be well tolerated. Should any unpleasant Are there any precautions or contraindications for symptoms arise, the patients should cease taking the Hydralyte? product. If a patient suffers from hereditary fructose Use with caution in patients with kidney disease or a intolerance, they are advised to consult their healthcare kidney condition, or those taking heart or blood professional before use, as the answer will vary on an pressure medication. individual basis.

Does Hydralyte contain? What is the sweetner used in Hydralyte? Isomalt No Hydralyte contains sucralose – a modified form of Saccharin No table sugar. Aspartame No Salicylates No What is the source of glucose in Hydralyte? Gluten No The source of glucose in Hydralyte is corn (also Wheat No called maize). Yeast No Nuts No To join our health professional network and access Animal products No additional resources please visit: Lactose or dairy products No www.hydralyte.com/healthprofessionals

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Dehydration and Oral Rehydration Solutions

Use under medical supervision Hydralyte LLC | 27070 Miles Road, Suite A, Solon, OH 44139 | T. 1-844-301-2109 | www.hydralyte.com