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Analysis of Drugs Manual September 2019
Drug Enforcement Administration Office of Forensic Sciences Analysis of Drugs Manual September 2019 Date Posted: 10/23/2019 Analysis of Drugs Manual Revision: 4 Issue Date: September 5, 2019 Effective Date: September 9, 2019 Approved By: Nelson A. Santos Table of Contents CHAPTER 1 – QUALITY ASSURANCE ......................................................................... 3 CHAPTER 2 – EVIDENCE ANALYSIS ......................................................................... 93 CHAPTER 3 – FIELD ASSISTANCE .......................................................................... 165 CHAPTER 4 – FINGERPRINT AND SPECIAL PROGRAMS ..................................... 179 Appendix 1A – Definitions ........................................................................................... 202 Appendix 1B – Acronyms and Abbreviations .............................................................. 211 Appendix 1C – Instrument Maintenance Schedule ..................................................... 218 Appendix 1D – Color Test Reagent Preparation and Procedures ............................... 224 Appendix 1E – Crystal and Precipitate Test Reagent Preparation and Procedures .... 241 Appendix 1F – Thin Layer Chromatography................................................................ 250 Appendix 1G – Qualitative Method Modifications ........................................................ 254 Appendix 1H – Analytical Supplies and Services ........................................................ 256 Appendix 2A – Random Sampling Procedures -
Product List March 2019 - Page 1 of 53
Wessex has been sourcing and supplying active substances to medicine manufacturers since its incorporation in 1994. We supply from known, trusted partners working to full cGMP and with full regulatory support. Please contact us for details of the following products. Product CAS No. ( R)-2-Methyl-CBS-oxazaborolidine 112022-83-0 (-) (1R) Menthyl Chloroformate 14602-86-9 (+)-Sotalol Hydrochloride 959-24-0 (2R)-2-[(4-Ethyl-2, 3-dioxopiperazinyl) carbonylamino]-2-phenylacetic 63422-71-9 acid (2R)-2-[(4-Ethyl-2-3-dioxopiperazinyl) carbonylamino]-2-(4- 62893-24-7 hydroxyphenyl) acetic acid (r)-(+)-α-Lipoic Acid 1200-22-2 (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 207557-35-5 1,1'-Carbonyl diimidazole 530-62-1 1,3-Cyclohexanedione 504-02-9 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol acetate 839705-03-2 1-[2-Amino-1-(4-methoxyphenyl) ethyl] cyclohexanol Hydrochloride 130198-05-9 1-[Cyano-(4-methoxyphenyl) methyl] cyclohexanol 93413-76-4 1-Chloroethyl-4-nitrophenyl carbonate 101623-69-2 2-(2-Aminothiazol-4-yl) acetic acid Hydrochloride 66659-20-9 2-(4-Nitrophenyl)ethanamine Hydrochloride 29968-78-3 2,4 Dichlorobenzyl Alcohol (2,4 DCBA) 1777-82-8 2,6-Dichlorophenol 87-65-0 2.6 Diamino Pyridine 136-40-3 2-Aminoheptane Sulfate 6411-75-2 2-Ethylhexanoyl Chloride 760-67-8 2-Ethylhexyl Chloroformate 24468-13-1 2-Isopropyl-4-(N-methylaminomethyl) thiazole Hydrochloride 908591-25-3 4,4,4-Trifluoro-1-(4-methylphenyl)-1,3-butane dione 720-94-5 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine Hydrochloride 28783-41-7 4-Chloro-N-methyl-piperidine 5570-77-4 -
Screening/Spot Test of Narcotics
Indian Journal of Forensic and Community Medicine 2020;7(4):160–165 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Forensic and Community Medicine Journal homepage: https://www.ipinnovative.com/journals/IJFCM Review Article Screening/spot test of narcotics A K Jaiswal1,*, Kamna Sharma2, Rohit Kanojia3, Sally Lukose4 1Dept. of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India 2Galgotias University, Greater Noida, Uttar Pradesh, India 3Dept. of Chemistry, University of Delhi, New Delhi, India 4CTM-IRTE, Faridabad, Haryana, India ARTICLEINFO ABSTRACT Article history: Narcotics are the substances used to treat moderate to severe pain. They could be natural like opiates such Received 25-11-2020 as morphine, codeine etc., synthetic like fentanyl, methadone etc., and semi-synthetic like oxycodone, Accepted 02-12-2020 hydrocodone etc. These drugs act as pain relievers, induces the state of stupor or sleep, and increase Available online 08-01-2021 the physical dependence on them. In forensic autopsy case, the forensic pathologist may require a complete toxicological investigation for different poisons including stimulants. In India, Forensic Science Laboratories run by Government under the Home ministry usually carry out this. The samples must be Keywords: analysed by the forensic toxicologist/chemists/scientist. This article deals with the screening/spot test for Narcotics narcotics. It attempts to simplify the standard procedures in a step-wise manner, which can be of handy Screening reference for the forensic toxicologist. Spot test Drugs © This is an open access article distributed under the terms of the Creative Commons Attribution Opioids etc License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
Thoroughbred Racing
178CSR1 Title 178 Legislative Rule West Virginia Racing Commission Series 1 Thoroughbred Racing Effective: July 9, 2014 West Virginia Racing Commission 900 Pennsylvania Avenue Suite 533 Charleston WV 25302 305.558.2150 Fax 304.558.6319 Web Site: www.racing.wv.gov 178CSR1 Table of Contents SERIES 1 THOROUGHBRED RACING ____________________________________________________________________ 1 §178-1-1. General. ____________________________________________________________________________________ 1 PART 1. DEFINITIONS. _________________________________________________________________________________ 1 §178-1-2. Definitions. _________________________________________________________________________________ 1 PART 2. GENERAL AUTHORITY. ________________________________________________________________________ 9 §178-1-3. General Authority of the Racing Commission. ______________________________________________________ 9 §178-1-4. Power Of Entry. ______________________________________________________________________________ 9 §178-1-5. Racing Commission personnel. __________________________________________________________________ 9 §178-1-6. Ejection/Exclusion. __________________________________________________________________________ 12 PART 3. RACING OFFICIALS. __________________________________________________________________________ 12 §178-1-7. General Provisions. __________________________________________________________________________ 12 §178-1-8. Stewards. __________________________________________________________________________________ 14 -
Systematic Review of the Effect of Intravenous Lipid Emulsion Therapy for Non-Local Anesthetics Toxicity
Clinical Toxicology ISSN: 1556-3650 (Print) 1556-9519 (Online) Journal homepage: http://www.tandfonline.com/loi/ictx20 Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt, Sophie Gosselin & for the Lipid Emulsion Workgroup* To cite this article: Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt, Sophie Gosselin & for the Lipid Emulsion Workgroup* (2016) Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity, Clinical Toxicology, 54:3, 194-221, DOI: 10.3109/15563650.2015.1126286 To link to this article: http://dx.doi.org/10.3109/15563650.2015.1126286 Published online: 06 Feb 2016. Submit your article to this journal Article views: 692 View related articles View Crossmark data Citing articles: 2 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ictx20 Download by: [UPSTATE Medical University Health Sciences Library] Date: 03 August 2016, At: 08:19 CLINICAL TOXICOLOGY, 2016 VOL. 54, NO. 3, 194–221 http://dx.doi.org/10.3109/15563650.2015.1126286 REVIEW Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity Michael Levinea, Robert S. Hoffmanb, Vale´ry Lavergnec, Christine M. Storkd, Andis Graudinse, Ryan Chuangf, Samuel J. Stellpflugg, Martin Morrish, Andrea Miller-Nesbitth, Sophie Gosselini and for the Lipid Emulsion Workgroup* aDepartment of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA; bDivision of Medical Toxicology, Ronald O. -
NPPC GSP Oral Comments on the Kingdom of Thailand Maria Zieba
NPPC GSP Oral Comments on The Kingdom of Thailand Maria Zieba I appreciate the opportunity to represent the National Pork Producers Council at today’s hearing. NPPC is a national association representing 42 state producer organizations. It represents the federal policy and global interests of 60,000 U.S. pork producers. The United States is the top global exporter of pork, shipping nearly 2.5 million metric tons (MT), valued at over $6.4 billion to more than 100 nations in 2018. While Thailand consumes more than one million metric tons of pork annually, it imported no U.S. pork in 2018. That’s because Thailand effectively maintains a ban on U.S. pork. It defends its unwarranted ban on uncooked pork and other pork products by pointing to the use of ractopamine by some U.S. pork producers. Ractopamine hydrochloride (or ractopamine) is a feed ingredient approved for use in the United States for swine and beef cattle. In swine, it is used for increased weight gain, feed efficiency, and carcass leanness in finishing swine. Thailand maintains a ban on imports of pork produced with ractopamine, despite the approval by its own Ministry of Health for domestic use. After an extensive risk assessment, the U.S. Food and Drug Administration approved ractopamine for use in hogs in 1999, and no adverse human health problems have been reported since approval. In 2012, the Codex Alimentarius recognized the safety of ractopamine, establishing a recommended maximum residue level (MRL) for the product. At least 25 other countries have also approved the use of ractopamine in pork production, and an additional 75 countries permit imports of pork produced using ractopamine. -
Ractopamine and Clenbuterol Urinary Residues in Pigs As Food-Producing Animals
J. PLEADIN et al.: RTC and CLB Urinary Residues in Pigs, Food Technol. Biotechnol. 49 (4) 517–522 (2011) 517 ISSN 1330-9862 scientific note (FTB-2714) Ractopamine and Clenbuterol Urinary Residues in Pigs as Food-Producing Animals Jelka Pleadin1*, Ana Vuli}1, Nina Per{i1, Dinka Mili}2 and Nada Vah~i}3 1Laboratory for Analytical Chemistry, Croatian Veterinary Institute, Savska 143, HR-10000 Zagreb, Croatia 2Dubravica Swine Farm, Ltd., Pavla [toosa 109, HR-10293 Dubravica, Croatia 3Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia Received: January 17, 2011 Accepted: April 21, 2011 Summary The aim of the study is to determine residual ractopamine (RCT) and clenbuterol (CLB) concentrations in urine during and after their administration in anabolic dose to male pigs. RCT and CLB residues were determined using previously validated enzyme-linked immunosorbent assay (ELISA) as a quantitative screening method. Hydrolysis of urine samples with b-glucuronidase showed significantly higher (p<0.05) RCT residues. Study results showed RCT and CLB urine concentrations to vary greatly during oral treatment for 28 days, with maximal RCT and CLB concentration recorded on day 25 ((327.4±161.0) ng/mL) and day 20 ((68.4±32.2) ng/mL), respectively. RCT concentration of (57.1±10.6) ng/mL and CLB concentration of (38.8±20.1) ng/mL were measured on day 0 of treatment withdrawal; on day 7 of treatment withdrawal, the measured concentration of RCT ((5.0±0.9) ng/mL) was 20-fold of CLB concentration ((0.3±0.2) ng/mL). -
Meat and Meat Products Market Summary
Food Outlook Meat and meat products market summary Struggling with high feed prices and stagnating World meat market at a glance consumption, global meat production in 2012 is forecast to grow by less than 2 percent to 302 million Change: 2012 tonnes. As falling industry profitability has translated 2010 2011 2012 over 2011 estim. f'cast into modest output gains in the developed countries, million tonnes % most of the world expansion is likely to take place in WORLD BALANCE the developing countries, which now account for 60 Production 294.2 297.1 301.8 1.6 percent of world output. Virtually all of the sector Bovine meat 66.7 66.6 66.8 0.4 growth in 2012 is forecast to stem from the feed- Poultry meat 98.9 102.3 104.5 2.2 dependent poultry and pigmeat sectors, as gains in Pigmeat 109.3 108.8 110.8 1.9 Ovine meat 13.7 13.8 13.9 0.9 both bovine and sheep meat outputs are anticipated Trade 26.7 28.8 29.4 2.2 to be modest. Bovine meat 7.7 8.0 8.0 1.0 Concerns about the profitability of the meat Poultry meat 11.7 12.7 13.0 2.4 sector have been compounded by a weakening of Pigmeat 6.2 7.1 7.4 3.0 the growth of export markets, with trade expansion Ovine meat 0.8 0.7 0.8 1.9 anticipated to slow down to 2 percent from 8 percent SUPPLY AND DEMAND INDICATORS in 2011. -
Drug Screen Req. 06.2016.Docx Rev 2 Date 06-16 Page 1 of 2
TRUESDAIL LABORATORIES, INC. EXCELLENCE IN INDEPENDENT TESTING Established 1931 3337 MICHELSON DRIVE, SUITE CN 750 IRVINE, CALIFORNIA 92612 (714) 730-6239 FAX (714) 730-6462 www. truesdail.com DRUG SCREEN REQUEST FORM SAMPLE TYPE: Urine Blood Plasma Serum Collection Date: ______________ Doctor: ______________________________ Animal Name, HIP # or Other I.D.:______________________________________ Species: _________ Sex: ________ Owner’s name:_______________________ Pre-Purchase Screening (performed by LC/MS) LEVEL Ι: Includes only nonsteroidal anti-inflammatory drugs (phenylbutazone, $100.00 oxyphenbutazone, flunixin, naproxen, ketoprofen, firocoxib, diclofenac and meclofenamic acid). (Requires a minimum of 2 mL serum or plasma or 10mL of urine) LEVEL ΙΙ: Includes LEVEL Ι drugs plus testing for Domosedan (detomidine), $175.00 fluphenazine, acepromazine, promazine, chlorpromazine, triflupromazine, imipramine, propionylpromazine, clomipramine, and reserpine. (Requires a minimum of 4 mL of serum or plasma or 15mL of urine) LEVEL ΙΙΙ: Includes LEVEL Ι and ΙΙ drugs plus testing for butorphanol, triamcinolone $250.00 acetonide, betamethasone, dexamethasone, flumethasone, isoflupredone, predisone, methylprednisolone, prednisolone, albuterol, clenbuterol, terbutaline, and pirbuterol. (Requires a minimum of 5 mL of serum or plasma or 20mL of urine) LEVEL ΙV: TOBA Protocol Testing (urine and blood is required for this test) $300.00 (Requires a minimum of 6 mL of serum or plasma and 25mL of urine) *Rush testing is available for Level I, II or III -
Crystal Structure of Dopamine D1 Receptor in Complex with G Protein and a Non-Catechol Agonist
ARTICLE https://doi.org/10.1038/s41467-021-23519-9 OPEN Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist Bingfa Sun 1,7, Dan Feng1,7, Matthew Ling-Hon Chu1, Inbar Fish1, Silvia Lovera2, Zara A. Sands2,6, Sebastian Kelm 3, Anne Valade2, Martyn Wood2, Tom Ceska 3, Tong Sun Kobilka1, Florence Lebon4 & ✉ Brian K. Kobilka 1,5 Dopamine D1 receptor (D1R) is an important drug target implicated in many psychiatric and 1234567890():,; neurological disorders. Selective agonism of D1R are sought to be the therapeutic strategy for these disorders. Most selective D1R agonists share a dopamine-like catechol moiety in their molecular structure, and their therapeutic potential is therefore limited by poor pharmaco- logical properties in vivo. Recently, a class of non-catechol D1R selective agonists with a distinct scaffold and pharmacological properties were reported. Here, we report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 at 3.8 Å resolution. The structure reveals the ligand bound to D1R in an extended conformation, spanning from the orthosteric site to extracellular loop 2 (ECL2). Structural analysis reveals that the unique features of D1R ligand binding pocket explains the remarkable selectivity of this scaffold for D1R over other aminergic receptors, and sheds light on the mechanism for D1R activation by the non-catechol agonist. 1 ConfometRx, Inc., Santa Clara, CA, USA. 2 UCB Pharma, Braine-l’Alleud, Belgium. 3 UCB Pharma, Slough, UK. 4 UCB Pharma, Anderlecht, Belgium. 5 Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. -
Mandelin Reagent Instructions 1
MANDELIN REAGENT INSTRUCTIONS 1. Carefully shake bottle before each use. Open the WIM Scientific Laboratories Mandelin Reagent's factory seal. 2. Using the provided mini tester spoon, place at least .010 to .005 Grams (Tiny amount) of the questionable substance into the empty testing vial. 3. Add one or two drops of the Mandelin Reagent into the testing vial. The mandelin reagent is a strong yellow color.* 4. Watch carefully during the reaction time for color changes, any fizzing or smoking. 5. Refer to the color chart (on back) to determine what is present in the sample. 6. Rinse testing vial and the mini tester spoon thoroughly with soap and water after testing. 7. After successfully testing your substance, mini testing spoon and testing vial will need to be completely cleaned and dried before your next use. 8. After testing, the Mandelin Reagent bottle cap should be closed tightly and placed back into the bag to ensure no leakage or unwanted exposure occurs. 9. Also included are glow sticks and wristbands...because we love you. They may come in handy! Mandelin Reagent Kits are made to order with manufacture dates stamped on the bag and will be useful for at least 3-6 months depending on proper storage. Keep out of direct sunlight and hot temperatures (Above 120 degrees) for best results and lasting usage. Please note that a positive or negative reaction for any substance tested does not mean that a substance is safe. No chemical use is 100% safe. This will simply test for the presence of certain substances.