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Forensic studies * Interchim provides the following usefull products for forensics Technical tip – What are Forensics ? [] sciences : Forensic investigations are the application of science for legal issues and civil/public or private issues. This apply notably to High purity synthetic reference compounds for analysis of many persons identity authentication (crimes, parenthood, sexe, ), but also to goods compliance to norms and laws (certification, compounds analysed for forensic issues (drugs, pesticides, hormones,…) frauds), controlled substances use and traffic, art authentication, include notably … -drugs derivates : cannabinoids, cathinones, phenethylamines, A variety of techniques are performed to collect evidences and amphetamines, indanes, , , tryptamines, and analyze them. Fingerprint visualization require chemicals, gene identification require DNA collection tools, extration kits and phytocannabinoids, among many others. Include deuterated compounds, DNA-PCR kits. Analytical techniques require . reagents, isomers, DEA exempt references standards, analogs, derivatives and solvents, controlled substance standards, such as high- metabolites. common fragments found in EI-GC-MS analysis. performance liquid chromatography (HPLC), gas -other synthetic compounds are available, including pesticides (see the chromatography-mass spectrometry (GC-MS), atomic absorption spectroscopy (AA), Fourier transform infrared spectroscopy agrosciences catalog), toxicants (see the biochemicals catalogs), (FTIR), and thin layer chromatography (TLC). + hormones (see also cell biology catalog),… Applications examples : Forensic Assay kits for the detection of illegal drugs and their metabolites or degradation products, in human/animal/foods/vegetal > DRUGS & derivates stuffs. analysis of drug residues in blood or urine : sport ; custom importation ; … Stains for Forensics tests , for example the popular Amido black (Acid analysis of regulated drugs in production facilities : Black 1) >Sectors : police, customs, justice, industries

> PESTICIDES & derivat Forensic compounds analysis of pesticides and contaminants in foods, High purity synthetic reference compounds for analysis of and upstream natural stuff. cannabinoids, cathinones, phenethylamines, amphetamines, indanes, >Sectors : safety public services and privates opioids, benzodiazepines, tryptamines, and phytocannabinoids, among companies ; agroindustries ; environement ; police, many others. Include deuterated compounds, isomers, DEA exempt customs, justice, … references standards, analogs, derivatives and metabolites, common fragments found in EI-GC-MS analysis. Q HORMONES analysis of dopants in sport races Cayman Forensic Screening Kits analysis of growth and reproductive hormones used in in animals and foods, and environment samples Fentanyl Analog Screening (FAS) Kit The FAS Kit and its expansion pack (Emergent Panel Version 1) contain > GENES analog reference materials that will enable labs to screen for 150 ▪analysis of identity, parenting, sexuality abuses, … synthetic compounds, including more than 140 fentanyl analogs. analysis of adulteration of foods and other stuffs or Developped by the Centers for Disease Control and Prevention (CDC) ; goods Inquire. > Misceanous : TOXICANTS, RESIDUES,… Forensic Compounds References -drug derivates analysis of any kind of compounds released in the List of Fentanyl references [] environment with legal/forensic issues (from List of Utopioid references [] accident release to traces): List of Opiods references [] by industries of production and transformation List of Opioid Antagonists references [] (fumes, waters,…) by transportation activities : ships, trucks,containers,…

Reference Materials (RMs) are sold as neat solids in several sizes allowing for a low-cost, scalable, and highly-flexible option for analytical labs where accurate qualitative results are desired. Certified Reference Materials (CRMs) serve as Primary Standards for traceable quantitative analysis (according ISO/IEC 17025 and ISO Guide 34 :2000 (which include a certified property)).

Ask for other drugs, analogs and derivates, for screening or standard references purposes, as well as pesticides and other toxicants, hormones and any compound analyzed for legal reasons (forensics). Search also BioActive compounds (pure chemicals, not validated as standardized references). *

+Forensic Compounds References -pesticides Ask for pesticides pure compounds, CRM and standards

Forensic Assay kits Assay kits allow the detection of illegal drug and their metabolites or degradation products, in human/animal/foods/vegetal stuffs, as well as legal drugs typically in human urine, blood or oral fluids. Anabolic Steroid / 16β-Hydroxystanozolol Designer Drugs Narcotic Other Prescription Drugs Boldenone Azaperone Synthetic Cannabinoids (JWH-018) 6-Acetylmorphine (6-AM) Amphetamine Nandrolone Group Synthetic Cannabinoids (JWH-250) Alfentanil Amphetamine Specific Trenbolone Group Synthetic Cannabinoids (UR-144/XLR-11) Anileridine Amphetamine Ultra Synthetic Cathinones (Methcathinone) Buprenorphine Barbiturate Group Citalopram Benzodiazepine Group Anti -Inflammatories Carfentanil Buprenorphine Carprofen Hallucinogens & Diprenorphine Butorphanol Celecoxib Fluoxetine Etorphine Corticosteroid Group Anesthetics Fentanyl Fentanyl Dexamethasone Reserpine Dextromethorphan Hydromorphone Hydrochlorothiazide Flunixin Sertraline Levallorphan Hydromorphone Ibuprofen Lidocaine Lofentanil Ketamine Ketorolac Tricyclics Group LSD Meperidine Meperidine Methylprednisolone Mepivacaine /LAAM Methadone/LAAM Phenylbutazone Phencyclidine (PCP) Naltrexone/Nalbuphine /MDMA Salicylates Procaine Opiates Triamcinolone Acetonide Synthetic Cannabinoids (JWH-018) Droperidol /Oxymorphone Naltrexone/Nalbuphine Zomepirac Synthetic Cannabinoids (JWH-250) Pentazocine Opiates Synthetic Cannabinoids (UR-144/XLR-11) Propoxyphene Oxycodone/Oxymorphone #130719 THC Haloperidol Metabolites Sufentanil Pentazocine #103119/103116 Tramadol Phenytoin Group Tricyclics Group Stimulants Propoxyphene Tramadol Amphetamine Amphetamine Specific Trazodone Beta- Zolpidem Amphetamine Ultra Bronchodilator Group Caffeine/Pentoxifylline # Workplace Testing Theophylline /BZE-2 6-Acetylmorphine (6-AM) Amphetamine Cotinine Serum Amphetamine Specific Amphetamine Ultra Cotinine Urine Barbiturate Group Benzodiazepine Group Doxapram Buprenorphine Cocaine/BZE-2 Mazindol/Mazindol Metabolites Methamphetamine/MDMA Methadone/LAAM Methylphenidate Opiates Oxycodone/Oxymorphone Methamphetamine/MDMA Phencyclidine (PCP) Propoxyphene Nikethamide THC Synthetic Cathinones (Methcathinone) See also the catalogs cell biology assays, agrosciences. *

Neogen ELISA Kits for toxicoloy and drug-abuse forensics A comprehensive line of ELISA forensic drug testing kits are validated for screening hair, whole blood, urine, oral fluid, serum, plasma, meconium and other forensic samples. Assays detect over 300 major drug analytes and metabolites, including all major drugs of abuse . The following ELISA test kits for drug detection are intended for forensic toxicology samples . It is recommended that all suspect samples be confirmed by quantitative method such as GC/MS.

Benefits : • Validation for forensic matrices: whole blood, urine, hair, oral fluids, serum, plasma, meconium, breast milk and others • Low assay sample volume • Excellent reproducibility • High sensitivity • Easy-to-use formats (Liquid substrate and buffers provided with each kit ; Pre-coated microplates with removable stripes) • Non-radioactive • Experienced technical support staff • Customised single-line reporting software • More than 30 years of ELISA experience • Recommended extraction procedures provided (pour les kits Histamin,…° • Amenable to automation Automated and semi-automated equipment packages

Products for Multiple Drug Panels: • Impaired health care professionals • Drug facilitated sexual assault • Stimulants • Anabolic Steroids and Beta-Agonists • Hallucinogens and Anesthetics • Antidepressants and Sedatives • Narcotic Analgesics • Anti-inflammatories • Antipsychotics • Pain Management and Prescriptions

Pain Management Panel (ELISA) Hair Panel (ELISA) Detection kits for multiple drug panels include Antidepressants and Drugs of abuse detection Kits for human hair Sedatives targets: samples includes kits for:

• Amphetamine Specific • Cocaine #140118/140115╨ • Amphetamine Ultra • Methamphetamine / MDMA #140219╨ • Benzodiazepines (Oxazepam / ) • Opiates #140719/140715╨ • Buprenorphine • Buprenorphine / Norbuprenorphine • PCP #140519/140515╨ • Butorphanol • Synthetic Opiates #140419/140415╨ • Fentanyl • THC #140619/140615╨ • Hydrocodone • Hydromorphone ╨ For the determination of trace quantities of drug • Meperidine analytes in human hair follicle samples. Hair is easy to handle and store • Methadone Collection is far less invasive than urine and blood • MDMA / Methamphetamine Brief periods of non-use do not affect test results • Nalbuphine / Naltrexone A larger window of drug detection • Opiate Group Simple retesting • Oxycodone / Oxymorphone Difficult to adulterate test results • Propoxyphene These advantages have led hair samples to be • Tramadol extensively used in workplace testing, as well as in other areas, such as legal cases, occupational and traffic medicine, and for historical research.

Principle of Assays : direct competitive ELISA assays operate on the basis of competition between the drug or its metabolite in the sample and the drug-enzyme conjugate for a limited number of specific binding sites on the precoated microplate. Detection used HRP enzyme and TMB substrate.

Featured products : Acetaminophen Elisa Kit #132419 & #132415 (RTU) Intended Use: For the determination of trace quantities of Acetaminophen and/or other metabolites in human urine, blood, oral fluid. a qualitative one-step kit designed for use as a screening device for the detection of drugs and/or their metabolites. Principle : competition between the drug or its metabolite in the sample and the drug-enzyme conjugate for a limited number of antibody binding sites. Sensitivity : depending on samples and dilution, 13-2817ng/ml of acteminophen in blood, 24-8410ng/ml in urine. Specificity : crossreactivity is <2% with Procainamide, <1% with Ethyl-p-amino-benzoate,… See technical sheet.

Synthetic Cannabinoids (JWH-018) Test #133519(96well kit)/133515(480well kit) This Synthetic Cannabinoids (JWH-018) ELISA kit is a qualitative one-step kit designed for use as a screening device for the detection of JWH-018, JWH-073, JWH-200, JWH-015, JWH-019, AM2201 and other synthetic cannabinoid metabolites. The synthetic marijuana drug test kit was designed for screening purposes and is intended for forensic use only. Intended Use : For the determination of trace quantities of synthetic cannabinoids and metabolites in human blood, serum, and urine. Contact a Neogen representative for information on other matrices. Sensitivity : Compound JWH-018 : 0.98 ng/mL (I-50 in EIA Buffer) Specificity (Cross-Reactivity) : Compound Cross-Reactivity #33519/133515 #33719/133715 #133919/133915 JWH-018 100% 32.9% <0.004% JWH-073-N-(4-hydroxybutyl) metabolite 980% - 0.01% JWH-018 N-5-hydroxypentyl 753% - - JWH-200 612% 84% - JWH-018- N-pentanoic acid 612% 63.7% <0.004% JWH-073 490% 94.1 0.01% AM 2232 445% - 0.01% JWH-073 N-butanoic acid 426% 52.7% - (±) JWH-018-N-(4-hydroxypentyl) metabolite 392% 89.8% 0.04% AM 2201 350% 53.4% - AM 1220 288% - - JWH-022 233% 46.5% <0.004% AM-2201 N-(4-hydroxypentyl) metabolite 166% - <0.04% 1'-Naphthoyl Indole 153% - <0.004% JWH-018 N-(5-hydroxypentyl) β-glucuronide 136% - <0.004% MAM 2201 132% 30.4% <0.004% JWH-018 6-hydroxyindole 125% - <0.004% AM 694 108% 1% 0.03% JWH-019 94% 13.6% <0.004% JWH-015 83% 59% <0.004% JWH-018 4-hydroxyindole metabolite 60% 9.9% <0.004% … JWH-250 . 100% 0.04% JWH-250 N-(5-carboxypentyl) metabolite . 159.9% 0.07% JWH-250 N-(5-hydroxypentyl) metabolite . 158% 0.1% JWH-250 N-(4-hydroxypentyl) metabolite . 123.4% 0.07% JWH-073 N-(4-hydroxybutyl) metabolite . 106.8% 0.1%/ JWH-018 N-(5-hydroxypentyl) metabolite . 103.9 0.01% … UR-144 N-pentanoic acid <0.01% <0.004% 100% A-796260 . . 88.89% UR-144 N-(5-hydroxypentyl) metabolite <0.01% <0.004% 88.89% (±)-UR-144 N-(4-hydroxypentyl) metabolite. . . 61.54%

THC (Hair) #140619, 96 well kit #140615, 480 well kit The THC Hair ELISA (Enzyme-Linked Immunosorbent Assay) test kit is a qualitative one-step kit designed for use as a screening device for the detection of THC and/or their metabolites in hair. The kit was designed for screening purposes and is intended for forensic use only. Intended Use : For the determination of trace quantities of THC and/or other metabolites in human hair samples. Contact a Neogen representative for information on other matrices. Specificity (Cross-Reactivity) : Compound Cross-Reactivity (-)-11-nor-Δ9-THC-9-COOH 417% (-)-11-nor-Δ9-THC-9-COOH-glucuronide 313% (-)-11-nor-Δ8-THC-9-COOH 167% (+/-)-11-nor-Δ9-THC-9-COOH 125% (+/-)-11-Hydroxy-Δ9-THC 83% Δ9-THC 86% Cannabinol 39% Δ8-THC 35% 28%

List of ELISA kits for FORENSICS () 6-Acetylmorphine (6-AM) Droperidol #101619 Methylprednisolone #104519 16β-Hydroxystanozolol #103519 Ethacrynic #Acid #101719-1 ⌐ Naltrexone/Nalbuphine(RTU) #133019 Acetaminophen (RTU) #132419 Etorphine1C8930 #101819 Nandrolone #104619 Alfentanil #103619 ⌐ FenProporex #182019/182016/182013 Nikethamide #109919 ⌐ Amfepramone . #108419 ⌐ Opiates Group #130419 RTU)◙/120319╔, Amphetamine #105219-1 Fentanil Group #100519 #140319/140315╨ Amphetamine #Specific(RTU)◙ #132319 Fentanyl(RTU) #131519 Oxycodone/Oxymorphone(RTU)◙ #130719 Amphetamine #Ultra(RTU)◙ #130819 Fexofenadine/Terfenadine #181419 ⌐ Pentazocine #103119 Anileridine #105519 Flunitrazepam #109519 Phencyclidine #(PCP)(RTU)◙ , #140519/140515╨ /Apocodeine #109119 Flunixin #101919 #130519/120419╔/140519╨, PCP #140515 Azaperone #100919 Fluoxetine #107619 Phenylbutazone #104719-1 Barbiturate Group(RTU)◙ #130619 Fluphenazine #104119 ⌐ Phenytoin(RTU) #132119 Benzodiazepine Group(RTU)◙ Furosemide #104219-1 Procaine #103219 (oxazepam/clonazepam) #130119 Glycopyrrolate #102019 Promazine Group #100719 Benzylpiperazine #108319 ⌐ #109219 ⌐ Propoxyphene(RTU) #131119 Boldenone #101019 Haloperidol #104319-1 #107319 Bronchodilator Group #100319 Haloperidol Metabolites #102119 ⌐ Pyrilamine #105919 Bumetanide #103719-1 Hydrochlorothiazide #180319 #106519 Buprenorphine(RTU) #131919 Hydromorphone(RTU) #132219 Reserpine #104819 Buspirone #108719 ⌐ Hydroxyzine #105719 Salicylates (RTU) #133619 ⌐ Butorphanol #101119 Ibuprofen #180219 Sertraline(RTU) #131319 Caffeine/Pentoxifylline #106419 Ipratropium/Atropine #107119 Stanozolol #103319 Carfentanil #103919 #102219 Sufentanil #104919 Carisoprodol(RTU) #132519 Ketamine(RTU) #131719 Sulfamethazine #103419 ⌐ Carprofen #181119 ⌐ Ketoprofen #108219 Synthetic Cannabinoids#(SPICE) (RTU) #133519; Celecoxib #180719 Ketorolac #105619 ⌐ JWH-018) #133519/133515; JWH-250 Citalopram(RTU) #132719 ⌐ Levallorphan #102319 #133719/133715; (UR-144/XLR-11) ⌐ Clenbuterol #101219 Lidocaine #106719-1 Synthetic Cathinones (Methcathinione) / #180119 Lofentanil #102419 #181819/181815 Cocaine/Benzoylecgonine-2 (RTU)◙ LSD(RTU) #130219 ⌐ Synthetic Opiates #140419/140415 #130319/130315, #140118/140115╨ Mazindol/Mazindol Metabolites #102519 THC(RTU)◙ #140619/140615╨, #131019/120519╔ Corticosteroid Group #100419 Meperidine (RTU) #133119 Theophylline #106019 ⌐ Cotinine #(Serum) #CT-96-S Mephentermine #107219 Tramadol(RTU) #131819 Cotinine #(Urine) #CT-96-U Mepivacaine #102719 Trazodone(RTU) #132819 Creatinine #133319 (RTU) #133419 Trenbolone #109719 Cromoglycate #105819 #107919 ⌐ Triamcinolone #Acetonide #105119 Dantrolene #106319 Methadone(RTU) #131619 Tricyclics Group(RTU) #132019 Dermorphin 181919 Methadone/LAAM(RTU) #132919 Zolpidem(RTU) #132619 Detomidine #181319 Methamphetamine/MDMA(RTU)◙ #130919, Zomepirac #109619 Dexamethasone #101519 #120219╔, #140219╨ / #181719╨ Dextromethorphan(RTU) #131419 ⌐ #108019 Cocaine #140115 Diprenorphine #106119 ⌐ Methotrexate #107519 Methamphetamine/MDMA #140215 Doxapram #106219 Methylphenidate/Ritalinic Acid(RTU) #133219 ◙ : Matric specific calibrators included. RTU : Ready-To-Use Assay ╨: Hair ; ╔: Oral Fluid ⌐ : Minimum lead times and order quantities required ()

Oral Fluid System Samples collect and Assays

This oral fluid product line includes the NeoSal® Oral Fluid Collection System and a panel of oral fluid ELISA test kits optimized with the NeoSal device. Also available is the UltraSal-2, a split-specimen oral fluid collection device that can be used for multiple testing applications.

Our oral fluid ELISA kits include assays for cocaine, methamphetamine, opiates, PCP and THC. All of our oral fluid kits are designed as ready-to-use assays that do not require dilution of the drug enzyme conjugate prior to assay setup. When using these kits with the NeoSal, no sample treatment is required prior to assay due to the built-in 1:4 dilution of the collection device. Samples do not need to be plunged, centrifuged, diluted or transfered to another test tube. Simply discard the collection pad and process the sample directly from the buffer tube.

• Oral Fluid ELISA Kits

Features of the Oral Fluid ELISA Kits: • Optimized with the NeoSal Oral Fluid Collection System • High sensitivity • Excellent reproducibility • Compatible with automated and semi-automated equipment • Available in 96 and 480 well assay

Ordering Details : ELISA kits Product # Cocaine/BZE ELISA kit (Oral Fluid) #120119 Methamphetamine ELISA kit (Oral Fluid) #120219 Opiates ELISA kit (Oral Fluid) #120319 PCP ELISA kit (Oral Fluid) #120419 THC ELISA kit (Oral Fluid) #120519

• Oral Fluid Multi-Analyte Calibrators The following sets of oral fluid multi-analyte calibrators consist of four, ready-to-use calibrators in a synthetic oral fluid matrix. This set is intended for the qualitative evaluation of NeoSal oral fluid samples when used with our oral fluid ELISA kits.

Ordering Details : Multi-Analyte Calibrator Set #128100, 1set of 4u

NegativeCalibrator Low Positive Calibrator Cut-off Calibrator High Positive Calibrator Benzoylecgonine 0 ng/mL 2.5 ng/mL 5 ng/mL 10 ng/mL S(+) Methamphetamine 0 ng/mL 6.25 ng/mL 12.5 ng/mL 25 ng/mL 0 ng/mL 5 ng/mL 10 ng/mL 20 ng/mL PCP 0 ng/mL 1.25 ng/mL 2.5 ng/mL 5 ng/mL (-)Δ9-THC 0 ng/mL 0.5 ng/mL 1 ng/mL 2 ng/mL

Accessory ELISA reagents for forensics β-Glucuronidase Reagent Pack #301605, Single Reagent Pack 6 months when Reagent A is stored at 4°C and Reagent B is stored at -20°C Allows for better detection of total with Neogen's Benzodiazepine Group (Oxazepam/Clonazepam) kit.

NeoSal Buffer #120176, 500 mL 120177,1 L 8 months when stored at room temperature (15-25°C) Designed to stabilize oral fluid specimens following collection and during transit, it can also be used to dilute additional oral fluid samples in preparation for immunoassay

See also the immunological catalog (substrates, buffers,…)

Tests for drugs Neogen ELISA kits for prescripted drugs monitoring and abuse A comprehensive line of ELISA drug testing kits detect over 300 major drug analytes and metabolites. ELISA test kits are intended for • Impaired health care professionals mulitple drug detection in biological samples in health care research • Drug facilitated sexual assault (treatment monitoring ; drug abuse ;…) • Stimulants • Anabolic Steroids and Beta-Agonists • Hallucinogens and Anesthetics • Antidepressants and Sedatives Ask for any drug detection kit. Examples : • Narcotic Analgesics Ibuprofen #180219 • Anti-inflammatories Ketoprofen #108219 • Antipsychotics Salicylates #133619 • Pain Management and Prescriptions

Amphetamine Amphetamine Specific Hydrochlorothiazide Opiates Amphetamine Ultra Hydromorphone Oxycodone/Oxymorphone #130719/130715 Barbiturate Group Ketamine Pentazocine #103119/103116 Benzodiazepine Group Meperidine Phenytoin Buprenorphine Methadone/LAAM Propoxyphene Butorphanol Methamphetamine/MDMA Tramadol Carisoprodol Methylphenidate Trazodone Fentanyl Naltrexone/Nalbuphine

Tests for speciation Neogen ELISA kits quick, easy tests for meat speciation Reveal kits are immunochromatographic lateral flow assays used for the rapid, qualitative detection of meat from particular species in raw and processed raw meat products, such as sausages or burgers.

• Detects 0.5% of raw target meat in a non-target meat matrix. • Five minute test time – result in 6 min • Simple extraction and test procedure • Cross Reactivity : Venison

Intended use : by quality control personnel or other personnel familiar with handling meat samples only in an industrial food manufacturing or preparation context.

Reveal® rapid test for Red #9533, 10tests Reveal® rapid test for Pork Yellow #9532, 10tests Reveal® rapid test for Poultry Blue #9534, 10tests Reveal® rapid test for Sheep Green #9535, 10tests Reveal® rapid test for Horse Orange #9531, 10tests Contains : 10tests (Qualitative) (L) : 10 Reveal for lateral flow test strips 10 clear sample cups 10 vials of sample diluent 10 disposable 100 μL fixed volume pipettes 10 disposable 200 μL fixed volume pipettes

Materials Required But Not Provided : Extraction containers to contain 10 mL deionized or distilled water for extraction Deionized or distilled water Reveal sample cup rack (#9475) Timer (#9426) Mincer or knife to finely chop sample Scale capable of weighing 0.5–400 g ± 0.1 g (#9427) Measuring cylinder capable of measuring 10 mL Reveal for Meat Speciation Swabbing Kit (#9541, contains 50 swabs)

Accessory product : Reveal® Meat Speciation Swabbing Kit #9541, 50swabs Pkg dimension : 10.50 IN x 7.00 IN x 1.00 IN. Weight : 0.2LB ; (Z)

R-Biopharm kits for food industry and research A comprehensive range of assays kits for : Industries Analytes Technologies Beverages ELISA Cereals Enzymatic assays Dairy Lateral flow assays Fruits, spices & nuts ↓ Microbiological assays Meat -> Ask <- Purification columns Prepared foods Ready-to-use media Seafood Real-time PCR Testing laboratories ↓

Analytes Constituents determination Vitamins Microbiology Acids : Acetic acid; L-Ascorbic acid; Citric acid; Formic acid; Folic acid ; Pantothenic acid ; Vitamin C (L-Ascorbic Assay kits for Indicator organisms ; Spoilage organisms ; Pathogenic Gluconic acid; L-Glutamic acid; D-3-Hydroxybutyric acid; D- acid) ; Vitamin B1 (Thiamin) ; Vitamin B2 (Riboflavin) ; bacteria ; Viruses ; Bacterial toxins Isocitric acid; L-Lactic acid; D-Lactic acid; L-Malic acid; D- Vitamin B3 (Niacin) ; Vitamin B6 (Pyridoxin) ; Vitamin B7 Immunological test (RIDASCREEN® ELISA) Malic acid; Succinic acid; Tartaric acid; (Biotin) ; Vitamin B12 (Cyanocobalamin) ; Inositol real-time PCR) (SureFast® Kits) Sugars : D-Glucose ; D-Glucose / D-Fructose ; Lactose / D- Dish culture : Ready-to-use nutrient plates (Compact Dry) and Ready- Galactose ; Maltose / Sucrose / D-Glucose ; Raffinose ; Food allergens to-use agar plates (RIDA®STAMP) Starch ; Sucrose / D-Glucose ; Sucrose / Glucose / Fructose Gluten containing cereals ; Milk ; Eggs ; Soy ; Peanuts ; Others : Acetaldehyde Ammonia Cholesterol Copper Ethanol Tree nuts ; Fish ; Shellfish ; Celery ; Mustard ; Sesame Residues and contaminants Glycerol Iron Nitrate D-Sorbitol & Xylitol Sulfite Urea seeds ; Lupin - : Bacitracin ; Chinolones ; Chloramphenicol ; Nitrofurans ; β-Lactams (Penicillin) ; Streptomycin ; Sulfonamides ; Food adulteration Genetically modified organisms Tetracycline -qPCR test kits for identifying species : -Residues of hormones : androgens (Testosterone ; fish : Salmon, red salmon, king salmon, humped salmon, (GMO) Methyltestosterone ;19-Nortestosterone ; Trenbolone) ; oestrogens ( atlantic salmon ; Trout, rainbow trout ; Halibut ; Haddock ; SureFood® plant qPCR kits for +40 GMO plants (soya, Diethylstilbestrol (DES) 17ß-Estradiol Ethinylestradiol Codfish, cod, pollack ; Coalfish ; Hake, whiting Canola, Corn) Zeranol) ; Gestatin (Acetyl estagenes ; Melengestrol acetate) ; β- Meat : ; Pig ; Horse ; Donkey ; Chicken ; Turkey ; Agonists (Clenbuterol ; Ractopamine) Rabbit ; Sheep ; Goat ; Water buffalo ; Cat ; Dog Mycotoxins -Veterinary : fungicides, anthelmintics, corticosteroids, -ImmunoAssays : ELISA kits and Lateral flow assays Cards Columns coccidiostats ; tranquilizers. Milk : CIS-Casein Kit (cow/sheep/Goat) #R4303 ; Melanin Kit Cartridges, reference materials and standards, for -Chemical contaminants : bisphenol A (BPA) #. Aflatoxin Citrinin ; DON (Vomitoxin) ; Fumonisin ; Ochratoxin ; Patulin ; Sterigmatocystin ; T-2 / HT-2 toxin ; ZearalenoneResidues

Most of these anAlytes are subject to legal limits :

*Adulteration : addition or exchange of species/materials and additives, a fraud in the food industry : Assays to detect animal species in meat products in needed for : -meat : test product adulterations (e.g. the use of horse meat instead of beef), as well as for religious demands (halal and kosher). -fish : test tot detect the addition or exchange of cheaper fish species instead of more expensive fish species. -milk : test lactoferrin concentration as a helpful indicator for the stage of lactation, for mastitis and for intra-mammary infection in dairy cows ; screen for raw and heated cow’s and buffalo’s milk ; detect Bovine Rennet Whey (BRW) (by-product of cheese production, added in milk) through K-Casein glycomacropeptide (CMP) part.

*Toxicants and Pollutants : -Mycotoxins are toxic metabolites produced by molds. -Drugs, hormones, antibiotics, chemicals added volatary or not (plastic release) contaminate foodSsand bewerages.

Please ask for the list of adulteration detection kits.

Chemicals and Stains for Forensics tests : High quality chemicals are critical to investigative fingerprints and blood evidences. Find her popular stains like Luminol for blood test and AmidoBlack for fingerprints and many more.

Stains for Forensics tests [d’après (18pdt ]201908) ]  Fluorescent Dye Stains for Fingerprint Visualization Safranine O #N1282A Rhodamine 6G #FP-DO7600 ; AX6LZ0 Sudan Black #FP-279042 ; #27904 Acid Fuchsin #BBQ89 ; 14552A Fluorescein #XMA880 Merbromin #XMF380 Nile Red (Nile Blue Oxazone) #FP-46875A ; #46875S

 Protein Stains Coomassie Brilliant Blue G-250 #077582 Crystal Violet #N1275A Oil Red O B13002

 Chemical Developers for Fingerprint Visualization Ninhydrin #JE8051 ; #188700(spray rgt) Phenolphthalein #036162 Amido Black (Naphtalene Black 10B) #07793A Lycopodium #XC779

 Blood Detection Reagents Luminol #FP-04247A O-Tolidine #37565 Tetramethylbenzidine #09290Q Finger printing products[]

 Blood Fixatives  Stains 5-Sulfosalicylic Acid #02892 DFO (1,8,-Diazafloure-9-one) DFO is effective on paper and some porous surfaces, it reacts with aminoacids and blood proteins. The image is highly fluorescent when illuminated with light at 568nm. It is dispersed with  Other stains for forensics HFE7100 (Methoxynonaflurobutane) [] Ninhydrin 5 Sulphosalicylic Acid 50-1800-50 CAS 5965-83-3; 5-Sulfosalicylic Acid is used as Blood Fixative in Forensics. It is highly  Solvants recommended for setting bloody prints or footwear impressions before performing enhancement Ethanol (Absolute) techniques that utilize an aqueous based formulation. This will prevent loss of detail of the Ethyl Acetate impression that could be caused during enhancement. Techniques that 5-Sulfosalicylic Acid Blood Fixative could be used with which include, but are not limited to Acid Yellow 7. Latent Print HFE 7100 Fluorescent Stain or Acid Violet 17 Latent Print Fluorescent Stain. HFE 71DE Acid Black 1 (Amido black) >80%CI20470 50-1000-25 Methanol (Absolute) Analytical Grade Acid Violet 17 >50% CI42650 Acid Yellow 7 >50% CI56205 Technical Tip : Finger printing with Ninhidrin [] Alpha- Napthoflavone Basic Red 2/Safranine O CI 50240 In 1996 CFC replacements were introduced which would offer CFC Yellow 40 Simbase Fluorescent Yellow 24710 dye like characteristics without the harmful effects. These alterantive Citric Acid - Anhydrous solvants[] were mainly used in the dispersion of Ninhydrin, a stain Cyano-acrylate(Super Glue Vapour-Ethyl Cyano-acrylate Adhesivie) which reacts with all Alpha-Amino Acids (with the exception of DFO (1,8,-Diazafloure-9-one) Cysteine) to give di-ketohydrinylidenediketohydindamine also Gentian Violet/Basic Violet 3 >85% CI42555 #N1275A known as Rohemanns Purple.' Iodine (99%) Terahedron: 1973 Vol 29 pp 4271-4272 Iron III Nitrate Nonohydrate ACS reagent >98% This reaction is the characteristic visual purple colour seen when Luminol (3-Aminophtalhydrazide) 98% identifying fingerprints. The importance of the Carrier solvent for Maleic Acid Laboratory Grade Ninhydrin is that it does not in any way react with the amino acids Silver Nitrate 99% of the fingerprint and is inert enough not to interfere with the porous Sudan Black >90% substrate in which the fingerprint is found. Zinc Chloride Crystals Laboratory Grade When using Ninhydrin or DFO, the carrier solvent HFE 7100 is the one of choice to Forensic Investigators as it does not absorb moisture, so aiding the print development making certain the ridge diffusion is minimised. Other advantages include minimal smearing in a wide variety of inks and substrates and an excellent environmental profile. Finger prints developed with HFE 7100 have crisper more regular ridges, with better definition that produce fingerprints containing 8 or more Galton points after 14 days. Whether using Ninhyrdin or DFO the dispersion ensures that the cracks and creases in the porous surface come into contact with the reporter molecule, qualitatively described by the wetting index as which is specific to the viscosity, surface tension and density of the solvent.

Others (Biochemicals & recipes)

Technical Tip – Forensics reagents [ ] See the list of biochemical components to make popular reagents below this table of recipes: Reagents Preparation of Reagent Used for Chen- Kao Reagent Reagent 1: This is prepared by adding 1 ml of Glacial Distinguish , Acetic Acid in 100 ml of Water, i.e., 1% (V/V) , norephedrine, and aqueous Acetic Acid solution. Reagent 2: This is prepared by dissolving 1 gm of methcathinone from amphetamine and Copper (II) Sulphate in 100 ml of Water, i.e., 1% methamphetamine (W/V) aqueous CuSO4 solution. Reagent 3: This is prepared by dissolving 8 gm of Sodium Hydroxide in 100 ml of Water, i.e., 2N aqueous Sodium Hydroxide solution Chromotropic acid reagent Dissolve 1 g of chromotropic acid disodium salt in Compounds having formaldehyde water, add 20 ml of 2% ascorbic acid solution, and dilute with water to 100 ml. Cobalt Thiocyanate( Ruybal test) Dissolve 2.0 g of cobalt (II) thiocyanate in 100 mL of Cocaine , Ephedrine, distilled water. Meperidine, Phencyclidine, Procaine, Propoxyphene and Pseudoephedrine methadone,etc. Dille-Koppanyi Reagent Solution A: Dissolve 0.1 g of cobalt (II) acetate dihydrate in 100 mL of methanol. Add 0.2 mL of glacial acetic acid and mix. Solution B: Add 5 mL of isopropylamine to 95 mL of methanol. Dragendorff reagent 1 gm of Bismuth SubNitrate is dissolved in 3 ml. of Primary or Secondary or tertiary amine 10M of Hydrochloric Acid. It is diluted to 20 ml. 1 gm & benzodiazepines of Potassium iodide is dissolved in it Amphetamine Active constituents of Papaver somniferum Duquenois-Levine Reagent Solution A: Add 2.5 mL of acetaldehyde and 2.0 g of vanillin to 100 mL of 95 percent ethanol. Solution B: Concentrated hydrochloric acid. Solution C: Chloroform Ferric Chloride Reagent Dissolve 2.0 g of anhydrous ferric chloride or 3.3 g of Compounds containing , ferric chloride hexahydrate in 100 mL of distilled , Salicylates, water. Fisher Morris Reagent Reagent A: Concentrated Formic Acid. Reagent B: Heroin, Diphene, hydramine, 5% aqueous Sodium Nitrite solution. Diazepam Forrest Reagent 0.2% solution of Potassium Dichromate, 30% (v/v) Phenothiazines solution of Sulphuric Acid, and 20% solution of and related compounds Perchloric Acid and a 50% solution of Nitric Acid in equal volumes are mixed. FPN Reagent 5 ml. of Ferric Chloride solution, 45 ml. of 20% (w/v) Phenothiazines solution of Perchloric Acid and 50 ml. of 50% (v/v) solution of Nitric Acid is added to make a final solution Frohde’s Reagent Dissolve 0.5 g of molybdic acid or sodium molybate MDA (amphetamine) Oxycodone in 100 ml of hot concentrated sulfuric acid Mandelin Reagent Dissolve 1.0 g of ammonium vanadate in 100 mL of amphetamines and opiates Ergot concentrated sulfuric acid. Alkaloids. Carefully add 100 ml of concentrated sulfuric acid to 5 Primary test for opiates, hallucinogens, ml of 40 percent formaldehyde and amphetamines Mayer’s Reagent Potassium Mercury Iodide prepared by dissolving Nicotine 1.357 gm of Mercuric Chloride and 5 gms of Potassium Iodide in 100 ml of water Dissolve 1 g of selenious acid in 100 ml of MDA, concentrated sulfuric acid. p-DMAB Reagent Add 2.0 g of p-DMAB to 50 mL of 95 percent ethanol LSD (Para-Dimethylaminobenzaldehyde ) and 50 mL of concentrated hydrochloric acid. Scott Reagent 2 gms of Cobalt Thiocyanate in water and diluted with Cocaine 96% Glycerine in water in 1:1 proportion. Simon’s Reagent Solution A: Dissolve 1 g of sodium nitroprusside in 50 mL of distilled water and add 2 mL of acetaldehyde to the solution with thorough mixing. Solution B: 2 percent sodium carbonate in distilled water Van- Urk Reagent OR Ehrlich’s 1 gm. of p-amino benzaldehyde is dissolved in 100 ml. Lysergic Acid Diethylamide reagent ethanol and adding 10 ml. of Hydrochloric Acid. Zwikker Reagent Solution A: Dissolve 0.5 g of copper (II) sulfate Barbiturates pentahydrate in 100 mL of distilled water. Solution B: Add 5 mL of pyridine to 95 mL of chloroform

List of biochemicals for above forensics tests description and search online

Acetic acid (Glacial ) CAS:64-19-7 #IS319B . Acetaldehyde CAS:75-07-0 #03796.X . Acetate dihydrate Ammonium vanadate - Ascorbic acid CAS:50-81-7 #FZ8453(& 1I0480) Bismuth SubNitrate CAS:10361-46-3 #C9047.X Chloroform CAS:67-66-3 #0469004 (04690K(RG), 04690G(99%) Chromotropic acid disodium salt Cobalt (II) thiocyanate CAS:3017-605 #PS5910 Copper (II) sulfate pentahydrate CAS:7758-99-8 #083858 DMAB Reagent (para-DiMethylAminoBenzaldehyde ) Ethanol. (>95%) CAS:64-17-5 #N1338A (&10041) . Ferric Chloride CAS:10025-77-1 #VQC35.X! Ferric Chloride hexahydrate Formic Acid. CAS:64-18-6 #03636H Hydrochloric acid (concentrated) CAS:7647-01-0 #1M0820 Isopropylamine CAS:75-31-0 #037360 Mercuric Chloride CAS:7487-94-7 #14991A Methanol. CAS:67-56-1 #057020 Molybdic acid CAS:10102-40-6 #N12790(& CAS:7782-91-4(free); N12151(Ammonium salt) Nitric Acid CAS:7697-37-2 #15078A.pdf (&15078E) Perchloric Acid CAS:7601-90-3 #14629H Potassium Iodide CAS:7681-11-0 #N12730.pdf Pyridine CAS:110-86-1 #JC299.X Selenious acid CAS:7783-00-8 - #02800V (& IN5683(HPCL grade, IN5676(Spectrometry grade) Sulfuric acid (concentrated) CAS:7664-93-9 #YA3420(72%) (& 50%, 0.1N to 5N) Sodium nitroprusside CAS:14402-89-2 #XD5454 . Sodium molybate CAS:7631-95-0 #A27739(& #AX77L0) . Sodium Nitrite CAS:7362-00-0 #141998 ! (&JF7622) . Vanillin CAS:121-33-5 #B2V4Y1. Water (UltraPure) CAS:7732-18-5 #45742B (&45742B, GS347C)

Tech tip – applications guides Please ask for applications notes1 curents, 5 la wall posters, 7 scientific posters] to help identify drugs analogs and their metabolism :

Laboratory Guide for Fentanyl Identification, Naming, and Metabolism The basic fentanyl scaffold can be modified in four different regions leading to a myriad of new fentanyl varieties. Aks our laboratory guide for bench chemists and toxicologists to help identify novel fentanyl analogs and their metabolism, with guidelines for naming . Common Fentanyl MS Fragments . Mass Spectrum of Fentanyl and Tips for Interpretation . Major Predictive Patterns . Fentanyl Metabolism: Typical Phase I Metabolites . Differentiation of Isobaric and Isomeric Fentanyl Analogs by Gas Chromatography-Mass Spectrometry (GC-MS) Laboratory Guide for Utopioid Identification, Naming, and Metabolism U-drugs or U-compounds, utopioids are characterized by a trans-cyclohexanediamine moiety and their substituted phenyl ring, linked together by an amide carbonyl group. . Common EI-GC-MS Utopioid Fragments . Mass Spectrum of U-47700 and Tips for Interpretation . Halogen Isotope Patterns . Utopioid Metabolism Laboratory Guide for Phytocannabinoids Biosynthesis, Naming, and Numbering[] Laboratory Guide for Synthetic Cannabinoids Biosynthesis, Naming, and Numbering[] Laboratory Guide for Cannabinoids Receptors[]

Identification (Paternity, missing persons, criminals,…) mtDNA analysis [] Forensic laboratories occasionally use mtDNA comparison to identify human remains, and especially to identify older unidentified skeletal remains. Although mtDNA is not specific to one individual, unlike nuclear DNA, it is believed that mtDNA is better suited to identification of older skeletal remains than nuclear DNA because the greater number of copies of mtDNA per cell increases the chance of obtaining a useful sample, and because a match with a living relative is possible even if numerous maternal generations separate the two.

Selection of reagents and kits for mtRNA study Extraction and purification kits RNA/DNA Purification Kit #48700 Urine DNA Isolation Micro Kit #18100 Has been used to purify mtRNA from urine as a liquid biopsy for IgA Nephropathy[blog]. Antibodies mtRNA POLYMERASE ANTIBODY (FITC) #ORB189676 Lysates mtRNA POLYMERASE LYSATE #NBL1-14597

Species identification

Origen DNA control for forensics The female (9947A) and male (9948) control DNAs are U.S forensic DNA standards validated by National Institute of Standards and Technology (NIST) and used by Federal Bureau of Investigation (FBI). The genomic DNA is isolated from 9947A and 9948 cell lines to serve as positive controls in various applications:

Ancestry Determination Population Genetics Paternity Tests Crime Resolution Reference DNA for Nextgen sequencing

NIST Standard Reference Material 2391b NIST Standard Reference Material 2392 forensic magnifier

OriGene’s 9947A and 9948 in the publications: Development and Validation of the AmpF‘STR MiniFilerTM PCR Amplification Kit; J Forensic Sci, July 2008, Vol. 53, No. 4 Development and Validation of the AmpF‘STRs YfilerTM PCR Amplification Kit; J Forensic Sci, Jan 2006, Vol. 51, No. 1 Developmental Validation of the QuantifilerTM Real-Time PCR Kits for the Quantification of Human Nuclear DNA Samples; J Forensic Sci, July 2005, Vol. 50, No. 4

SKU Product Name Size FD100003 5X TE (50 mM Tris pH 7.5, 0.5 mM EDTA) buffer containing 250 ug/ml of glycogen 1ml FD100002 Female Human Forensic Control DNA 9947A (100 ng/ul) in TE buffer with 50 ug/ml glycogen 100ul FD200001 Female Human Forensic Control DNA 9947A in TE Buffer (1 ng/ul) 100µL FD200002 Female Human Forensic Control DNA 9947A in TE Buffer (10 ng/ul) 100µL FD200005 Female Human Forensic Control DNA 9947A in TE Buffer (100 ng/ul) 100ul FD100006 Male Human Forensic Control DNA 9948 (100 ng/ul) in TE buffer with 50 ug/ml glycogen 100ul FD200003 Male Human Forensic Control DNA 9948 in TE Buffer (1 ng/ul) 100µL FD200004 Male Human Forensic Control DNA 9948 in TE Buffer (10 ng/ul) 100µL FD200006 Male Human Forensic Control DNA 9948 in TE Buffer (100 ng/ul) 100ul Large-scale quantities available. Please Inquire

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