Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd efrac ssace hog mrvn h emac ftemmrn fe rslnig[4,modulat- [14], crosslinking after membrane the membrane hydrophobic of the the sulfide permeance of polyarylene ing the Enhancement like improving [22]. directions through (PBIs) new searched membranes in is polybenzimidazole performance as well crosslinked as or [20], [21] (PASS) (PPy) 18], polypyrrole sulfone [17, and newmembrane (PPSU) polyphenylsulfone [19] polymers such [16], (PAN) (PES) used polyacrylonitrile including sulphone [15], (PA) mostpolyether commonly investigations polyamide the ofnumerous 14], dif- among [13, a (PI) from befound the focus polyimide can or as is type) Examples integral modifications. (the type), membrane selective material or composite of dense same materials polymeric thin-film the configuration the of (the basic on be one Their can reviews 3]. ferent which Detailed [2, structure, stability. in mem- microporous found chemical by concern be supported and drawbacks could layer typical thermal preparation their membrane as for but well used scale-up, as materials to fouling, easy and and compaction fabrication brane for In applications. inexpensive solvent-resistant are in especially they membranes, general, polymeric asymmetric are membranes used Widely compounds active biologically of separation for used Membranes 1.1 useinthefood, for them attractive makes in sub- industry. subproducts andconcentration and pharmaceutical as nanofiltration and found cosmetic separation from compounds membrane solution valuable through of permeate mill wastewaters recovery effluents the olive The diluted of in distillation. recovered osmotic were or thefractionation by polyphenols concentrated all sequently 10], recoveryof almost cited[9, the in be where 12], effluents can [11, ex- winery numerous from the polyphenols (NF) implementations Among and [8]. and nanofiltration polysaccharides catalysts and (UF) ultrafiltration (APIs) important ingredients thermally of amples, concentra- pharmaceutical purification [1 the active the years 6], and as recent [5, [7] compounds wastes industry the agro-industrial sensitive food in from the articles products are value-added review of techniques several fractionation separation in ontheir focused and membrane seen tion non- these be are of as can realization as well for applications it, areas ofpotential improve as Large to aqueous ways number the A in large and contained resistancy sources. solvent BACs natural fractionating different selectively (MMMs), from membranes extracts and/or matrix aqueous mixed concentrating of by class for newer treated attractive the BACsep- as of further are well as in view and membranes, Polymer solvent research concentration. scientific appropriate or of aration area by investigated intensively and extracted promising sources, are operations, natural membrane from (BACs) compounds Bioactive Introduction 1 usedfortheir results polymers achieve DOI: types and thelast with membrane about the only Keywords: not information detailed the readers we ongoing deliver on preparation. also, provide focused but We is field com- flavonoids. review active this and biologically This in polyphenols of nature. separation as from and such source concentration pounds, for primary technologies their membrane with using work products development other engineer and the food of part process important an is technology Membrane 2 1 compounds active biological of separation/filtration for application Polymer Tylkowski B. GRUYTER DE hscneti free. is content This Berlin/Boston. GmbH, Gruyter de Walter 2017 © Tsibranska I. Abstract: eteTcoòi el umc eCtlna arrd acll oig,407Traoa Spain. Tarragona, 43007 Domingo, Marcel.li de Carrer Catalunya, de Química la de Tecnològic Centre ugra cdm fSine nttt fCeia,Blasaaaeian akt,Sfi,Blai. E-mail: Bulgaria., Sofia, naukite, na akademija B'lgarska Chemical, of Institute Science, of Academy Bulgarian [email protected] 10.1515/psr-2017-0022 stecrepnigauthor. corresponding the is smercplmrcmmrns oymd,mtlogncframeworks metal-organic polyimide, membranes, polymeric asymmetric 1 .Tsibranska I. / – yrpii eaiu ftemmrn ntesac fhg eeto n reasonable and rejection high of search the in membrane the of behaviour hydrophilic 2 ’ olo.Ti sepcal refridsre that industries for true especially is This toolbox. s hsclSine eiw.21;20170022 2017; Reviews. Sciences Physical – 4]. 1 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd iua eaain aigit con h ilgclatvt,frisac h eoa of removal the forpar- instance to (UF-NF) for order activity, sequence in biological or membrane [36] the in account the membrane reviewed into of taking are flexibility separations membrane andsolute better ticular the achieve andanalysis to polarity of possibilities mechanism, sizes the for suchapplications sieving pore discuss of molecular the effects on Examples the depending membranes. distinguish behaviour nanofiltration separation and the ultrafiltration of of use wider 100 andover600 the solute numerousnon- between (MW) or ranges and their weight solute molecular MW typically intermolecular whose large compounds a thephenolic representatives, by are flavonoid and characterized flavonoid Examples are polarity. and molecular number different etc., the and groups, on distribution carboxylic depending hydroxyl, compounds individual rings, the aromatic of of structure chemical complex coupled with solvents organic multicomponent in are separations membrane of application the solid is chapter with this to interest special of extracts area natural An from compounds bioactive of purification and Concentration 1.2 – – of themolecular view in found in: – are sizes MMMs pore the different of with MOFs of applications use Successful the cut-offs. in weight achieved searched is are surface possibilities membrane the further across and and [32], membrane themembrane the throughout Concerning 31]. distribution membranes. MOF [30, asymmetric even integrally-skinned to an in morphology, an advantage given is being which examples flux, solvent membranes, to asymmetric skinned structure integrally membrane toMOF Inves- to TFC MOFs. The as directed of well are potential as nanofiltration separation solvent membranes, organic the (TFC) in incorporates application but potential membranes, with polymer tigations andmechanical the flexibility of possesses This structure characteristic strength chains. polymer towards The affinity void formation. better i. posses nonselective which MOFs, linkers, apossible using by avoiding achieved thus filler, is inorganic latter the and polymer the between hesion properties. thermomechanical and chemical better in as available solvent-resistant well as tocommercially compared Duramem as (e.g. [29] performance nanomembranes etc. polymeric rejection [29], orunchanged PI in better organosiloxane and well inorganic fluxes as [15], PA [27], network in PA in zeolite con- Zn UZM-5 nanoparticles, [26], or forembedding membranes [28] PI polydimethylsiloxane cited crosslinked in be in zeolites can Ti as [25], bonds. membranes examples hydrogen PPSU-based nanofiltration, or in solvent-resistant Cu forces taining of Waals area der phase. the van polymer In bonds, continuous used. covalent a through nanoparticles in be oxide particles can metal discrete nanopar- Various two dueto as inorganic visualized decline these incorporating be by flux between achieved can as connection which is The matrix, This such membrane [4]. drawbacks to the overcome aging into their ticles and or flux membranes and polymeric rejection of as compaction well as stability, mechanical and purification and implementation. separation for the metal potential and Concerning MMMs membranes. medium, solvent imprinted organic rejection molecularly in preserved capability the and flux with the higher overcome observed time, which same are 24] the values [23, In ability towithstand separa- membranes. used specific size-exclusion are conventional serve with enlarged imprinting the to media of molecular able involving limitations selectivity, technologies in organic membrane membrane for higher use new obtain needs, to tion order In well as membranes [22]. as environment chemical [19], harsh media in aqueous flux 2 PM scosikn gn n raoiioepeusr.Arve fogncsletmmrn appli- membrane solvent organic of review A precursor). organosilicone and agent crosslinking as APTMS anorganic incorporating membranes PI-based employing purification, API by modified is membrane polyethersulfone the of hydrophobicity the [33], treatment wastewater oil olive In ocrigfu eln n eeto ihMM ute eeomn ssace o mrvn thead- improving for issearched development further MMM, with and rejection decline flux Concerning enhanced in results which reported, was resistance compaction membrane improved cases, these all In organic composite are MMMs The etd n lgncetd rdcin eoa fecs egnsadrmvlo Psfo rai sol- [34]including organic in from APIs is given of removal and purification reagents API excess vents. of and removal recovery production, solvent oligonucleotide for and industry peptide pharmaceutical the in cation trimethoxysilane aminopropyl wastewater; oil olive the through in high rejections phenols and total and decline (COD) flux Demand reduced Oxygen in Chemical resulting im- structure, obtained, membrane were the properties in antifouling (F-MWCNT) proved nanotube carbon multiwall functionalized of concentration the ykwk n Tsibranska and Tylkowski – iudetato o rdcino ihvlepout rmntrlpatetat 3] h latter The [35]. extracts plant natural from products high-value of production for extraction liquid – – lrti eetv ae n ihypru support porous highly and layer selective ultrathin ovn neatoscnrsl nbge oeua tutrs hc determine which structures, molecular bigger in result can interactions solvent –

.pru rsaln aeil otiigmtlin/lsesadorganic and ions/clusters metal containing material, crystalline porous e. TiO – nrai ebae hc a edsge opsesgo chemical good possess to designed be can which membranes inorganic 2 n,Fe ZnO, , ™ 0,Eoi ebaeTcnlg t itnKye,UK), Keynes, Milton Ltd Technology Membrane Evonik 300, 2 O 3 Al , − rai rmwrs(Os ebae aeagreat a have membranes (MOFs) frameworks organic 2 O 3 iiacnann (SiO silica-containing , – ovn neatos h authors The interactions. solvent – nrai yrdntok(3- network hybrid inorganic – ups mle resistance smaller suppose 2 rcro fillers carbon or ) – hnfl composite thin-film “ heavier

a Additional Da. EGRUYTER DE ” phenolic – are Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd aua xrcs al al ..Auosextracts Aqueous 1.I. Table Table extracts. natural 1: Table molecular different with membranes using literature 42 the [12, in (MWCO) reported cut-off also weight solutions are multicomponent the sources from BACs the with natural of of interacting from fractionation preservation for solvent and originating examples solubility Positive hydroethanolic improved latter. to as the the leads of which well and properties [36] solute as antioxidant molecules solubility, their as within component compounds sides polar also phenolic and but nonpolar the be solutes, could the example sieving of solute An molecular and permeance complex mech- resistance the is the the polarity where explain hydrophobicity, level, to membrane molecular The reason enough a not realization. on is for separations mechanism difficult membrane more pressure-driven is in involved it anism though perspective, promising [39 another phenolic for substances is possibility as total the well hand, as other the On water dihydroflavonols of flavanones, concentration flavonols, flavones, the towards [38]; jections concentrated membranes the NF are and Examples UF uses. 100 of almost medical the [37]; and extract nutraceutical rosemary NF cosmetic, through food, for By ingredients selected. are functional fluxes from and permeate ofBACs extracted reasonable and amount rejections the high concentrating with is to improve membranes in that provided interest materials extraction The plant solid-phase extracts. with natural filtration from membrane compounds combining active biologically (OSN). separating/concentrating formem- nanofiltration in challenge solvent organic membranes them a of potential make the exploring solubility, level different molecular very a and on separation profile brane distribution MW large with sometimes flavanones and acids hydroxycinnamic [36]. wastewater; etc. proanthocyanidins mill juice concerning given olive extract; orange in sludge are blood phenols winery from from from pectin Examples anthocyanins extract; MW: permeate. the seeds high of grape and from low of properties separations antioxidant UF overall successful the affecting without classes GRUYTER DE Syzygium UF seeds Grape Extracted cumini seed Jamun material al al umrzsrcnl eotdivsiain,rpeettv o h plcto fpolymeric of application the for representative investigations, reported recently summarizes 1 Table Table plants, different from extracts natural the of properties bioactive unique and character multicomponent The (L.) umr fapiain fplmrcmmrnst eaaecnetaebooial ciecmonsfrom compounds active biologically separate/concentrate to membranes polymeric of applications of Summary h xrcsnwptnilapiain ra r fee o hs aua xrcsaspreservatives extracts natural these for offered are areas applications potential new extracts the UF Proc. Mem-brane ⇒ NF – 45]. India Ltd., Pvt. Membranes Permionics M/s. by supplied NF India Ltd., Pvt. Laval Alfa M/s by supplied UF (PES): Polyethersulphone (Nadir) UV050 (PVDF): difluoride Polyvinylidene (Nadir) UP150 (PES): Polyethersulphone Laval) (Alfa 15PP FSM0, : Fluoropolymer turer) (Manufac- material Membrane fractionating

250 100 50 150 MWCO eeto fatoynn nrsleetatuigasequence a using extract roselle in anthocyanins of retention % h xrcs hsotiigfatoserce ntre BACs, target in enriched fractions obtaining thus extracts, the

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re- % – 41]. 3 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 4 Soybeans tree mate from residues Bark ex- Roselle tract ykwk n Tsibranska and Tylkowski NF NF NF UF USA) Osmonics, (GE (PVDF) difluoride Polyvinylidene USA) (Osmonics, HL2521TF Desal membrane: thin-film (PVDF) difluoride Polyvinylidene Nadir); (Microdyn NP030 NP010, Polyethersulphone: Osmonics); (GE DK DL, thin-film: polysulfone, Polyamide (Koch); MPF34 MPF36, Composite: (TORAY); UTC60 composite: polyamide Crosslinked (FILMTEC); NF270 NF200, (Dow); NF90 composite: thin-film Polyamide Nadir) (Microdyn- UH050 UH030, UP150; UP020, UP005, Polyethersulphone: Osmonics); (GE GK GH, film: Thin GE, polyamide: Composite 150 150 150 1 – 150 – – – 300 300 400

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aSia oueGallic, module Spiral Da Da prlmdl aoy and Malonyl module Spiral cross-flow sheet, Flat glycitein) genistein, (daidzein aglycones glycitin), daidzin, (genistin, β gallate chin epigallocate- acid; quinic 4,5-dicaffeoyl zoic, dihydroxyben 3,4- quinic), (5-caffeoyl chlorogenic icyanin); ossyp- or side 3-sambubio- (cyanidin glucoside 3-xylosyl- cyanidin hibiscin); or bioside 3-sambu- (delphinidin glucoside 3-xylo-syl- delphinidin Anthocyanins: -glucosides [38] [57] 56] [55, EGRUYTER DE Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd EGRUYTER DE al al .I rai solvents Organic 1.II. Table Table Castanea Extracted oleuropein extracted Olive- leaves sativa material Solvent NF UF Process o,JP; Co., Denko Nitto NTR7450 ; JP Co., Denko Nitto NTR7430 ; JP Co., Denko Nitto NTR7410 (SPES): sulfone polyether Sulfonated JP Co, Denko Nitto NTR7250 (PVA): alcohol Polyvinyl USA KOCH, MPF44 USA; KOCH, MPF36 ; USA KOCH, MPF34 (SB/PS): support polysulfone on Silicone USA; Desal, Osmonics G5 USA; Desal, Osmonics G10 (PEG): glycine Polyethylene USA; Desal, Osmonics DL USA; Desal, Osmonics DK (PA/PS): support polysulfone on polyamide Aromatic Filtron) Pall Minisette, Membranes, (Omega polyethersulfone Modified material Membrane 1 300 150, 10 and 5 700 2 17.5 300 250 1000, 200, –

kDa, 2.5 – – Da

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MWCO D ltsheet, Flat kDa h retentate the of redilution batch incl. cross-flow tre cell stirred Dead-end module filtration (medioresinol) lignans and acids) vanillic and catechuic proto- (gallic, acids phenolic cirsiliol), and (quercetin Flavonoids luoen[60] Oleuropein opsto Ref. Composition ykwk n Tsibranska and Tylkowski 5,59] [58, 5 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 6 rp ed MeOH-H seeds Grape EtOH marc Grape thaceae ( album Viscum family) ( officinalis Sage-Salvia MeOH Persimmon coggygria Cotinus Camb.) brasiliense Pequi ( Loran- Labiaceae Caryocar ykwk n Tsibranska and Tylkowski L. ), L. 0 H 50 EtOH EtOH/H EtOH(azeotr.); MeOH; H2O v/v) (95:5 EtOH H (50/50); – 2 2 100

v/v % O O

– – – % H H H 2 2 2 2 2 O O O O NF O diafil.) (incl. UF NF NF UF UF NF UF NF ⇒ ⇒ UF MF ⇒ ⇒ MF UF ⇒ (PVDF) fluoride dene Polyvinili- FP200: (PS); phone Polysul- PU120: (PS); phone Polysul- PU608: ; (PES) sulphone Polyether- ES404: (PA) Polyamide AFC40: Italy) Milan, SpA, (HAR polyamide, Advanced membrane (PAN) lonitrile polyacry- and (PSF) Polysulfone China) Tianfang, (Tianjin, Polysulfone Brazil) SP, Paulo, Sao Company, Chemical Dow Filmtec, 90, NF (PA): Polyamide (prepared) membrane based (PAN)- lonitrile polyacry- and (PSF) Polysulfone UK) Evonik, (Duramem, polyimide Crosslinked 200 20 8 4 if MW diff. of PEG with exp. det. 470 specified Not 10 200 specified Not 200

kDa kDa

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aDead-end Da aDead-end Da oouua Oligomeric Monotubular wound Spiral tangential sheet Flat fiber Hollow cell stirred tangential sheet Flat tangential sheet flat glucose) or acid galactic with esters or polymers their epicatechin, (catechin, flavan-3-ol flavonoids: genic); neochloro- genic, chloro- ferulic, caffeic, (coumaric, cinnamic acids: lic polypheno- dins; proanthocyani- Rutin Epicatechin Quercetin Catechin phenols Total carotenoids flavonoids, acids, Phenolic tannin condensed including Polyphenols, carotenoids Polyphenols, acid rosmarinic and carnosol acid, Carnosic rutin quercetin, catechin, acid, gallic flavonoids: and Polyphenols [42] [65] [64] [63] [61] [64] [62] EGRUYTER DE Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd EGRUYTER DE oeayEtOH Rosemary balm Lemon L.) perforatum (Hypericum wort John St Sideritis EtOH Propolis, ’ s EtOH (96 EtOH EtOH EtOH H 2 0;

%) – – – H H H 2 2 2 NF O O O NF NF NF NF UK (Evonik, Duramem polyimide: Crosslinked UK (Evonik, Duramem polyimide: Crosslinked 240 Starmem polyimide: UK (Evonik, Duramem polyimide Crosslinked 240: StarmemTM : polyimide UK): (Evonik, Duramem : polyimide Crosslinked UK) Evonik, (Duramem, polyimide Crosslinked USA) (Osmonics, sulphone Polyamide/poly- NF90: TM 200 200 400 500 300 200 180 – – – – Da Da Da 500 500 900 300

aDead-end Da Da Da tangential sheet, Flat cell stirred Dead-end cell stirred Dead-end tangential sheet, flat filtration Dead-end filtration wound Spiral acid Rosmarinic acid Rosmarinic glucoside); 3-o- (quercetin quercitrin Iso- rhamnoside); 3-o- (quercetin quercitrin hypericin; hyperforin; galactoside); 3-o- (quercetin hyperoside ; catechin Quercetin; gluosides flavonoid 7 side, leucosepti- side,verbascoside, dulifolio- lavan- acid, Chlorogennic crysin) acid, p_coumaric methilether, ksin- pinoban- quercetin, acid, caffeic ksin, pinoban- brin, pinocem- (e.g. flavonols dihydro- flavanones, flavonols, flavones, flavonoids and compounds Phenolic ykwk n Tsibranska and Tylkowski – [37] [47] 50] [47, [48 [39 – – 50] 43] 41, 7 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 8 60 Polyphenon- tea Green wastes scolymus ( Artichoke capitatus Thymus oo ed EtOH seeds Cocoa Cynara ykwk n Tsibranska and Tylkowski L.) 10 EtOH EtOH Methanol Acetonitrile, Hexane, – 80

– – % H H 2 2 O NF O NF UF NF F RO NF, Denmark. Filtration, DDS 960PP, and Japan Tokyo, Abcor MPF-60, Denmark; A/S, Denmark DOW HR98PP, and HC-50 membranes; G-50 and G-20 G-10, G-5, USA, Systems, Desalination (PSF/PDMS) Polysulphone/polydimethylsiloxane polyamide; aromatic linked Cross- Osmonics: GE Polyamide; Osmonics: GE composite; thin-film Polyamide NF270: ; Osmonics) DK, 5 Desal (NF-DK; polyamide and Polysulphone Dow) (Filmtec- BW-30 Osmonics), (GE- SG RO: Dow). (Film-tec- NF-90 ics), (GEOsmon- HL DL, NF: membranes: RO and NF Commercial only tic characteris- Rejection 150 200 200 96 manufactures by provided charact. Retention – – – 99.5 Da 300 400

%

Da Da tre cell stirred Dead-end filtration tangential sheet Flat ededCarnosic end Dead ededPolyphenols end Dead catechins Polyphenols: flavones glucoside, Apigenin-7- glucoside, Luteolin-7- derivatives: flavonoid acid) caffeoylquinic (5- acid chlorogenic and acid) dicaffeoylquinic (1,5- cynarin : acids Phenolic acids rosmarinic and decamers) to (mono [69] [68] [67] [66] EGRUYTER DE Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd ocrigtemmrn efrac,teatospitdottene frsac n piiainwork optimization and scales. research industrial of and need bench the on out performed pointed and scaling-up. authors [52] in the membranes performance, (PEEK) membrane ketone the membranes ether Concerning PI polyether solvent-resistant ones as friendly with well environmentally made as account. with technology are solvents Investigations [51] of membrane into toxic performance. replacing membrane taken field by the Inthe be waste the worsening as one. in to without chemicals groups has hazardous leading agreen of membranes of discharge applications polymer as publications the media recent the organic of classified of in focus especially be production the and in to the been process also, has whole technology latter The the green makes a friendly of environmentally explorethe scope orderto as in viewed be [46]. can technologies processing, purification fine chemistry other in to is competitive OSN and purification by sustainable solvent solutes as of small OSN of view of removal potential in for important membranes stronger forsolvents as tighter of out being development effect pointed Further (the of point). volumes energy consumption being boiling reduced lower of higher and providing advantage with and the the environment conditions to also mild has requesting effluents solvents, solvent process toxic of distillation separation vol- traditional for solvent the alternative required to greener the compared a reduced as considerably recovery and solvent capability [48 rosemary, of This extraction 300) ume. better (Duramem extract even Sideritis ethanolic from and and equal proved recovery 200) pharmaceutical/solventsolvent solvent (Duramem [2]; treating 47] solvents polymeric for [37, different commercial balm tested from the lemon successfully oil are of 150), Examples separation [46]. Duramem [1]; industry and mixtures oil 122 the (Starmem and pharmaceutical membranes recovery the solvent OSN in of reported Applications are aspects. OSN economical by and safety environmental, for improved possibility showing and processes, rejections membrane reuse high solvent supposes rect solutes the of concentration Successful solvents extraction of Recovery 1.3 GRUYTER DE bark Eucalyptus waste and leaves Tobacco globulus h s fntrladrnwbesucso Ascmie ihmmrn eaaintcnqe that techniques separation membrane with combined BACs of sources renewable and natural of use The EtOH 02 (v/v) 80/20 EtOH nti ae ebaesprto elcsflyo osm xetdistillation/evaporation extent some to or fully replaces separation membrane case, this In . – H 2 O NF UF polyimide 240: Starmem polyimide Crosslinked UK): (Evonik, Duramem W60. EW Polysulfone: Osmonic GE 30, JW Polyvinylidenefluoride: Env. Orelis P5, PLEAIDE: Polyethersulfone Osmonic GE 1, GE composite: Polyamide – h S eaainpoes[6 1 2.Teie st reduce to is idea The 52]. 51, [46, process separation OSN the TM TM 400 300 60 30 5 1

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Da Da – tre cell stirred Dead-end tangential sheet Flat 0 hr h es ftepret as permeate the of reuse the where 50] rutinoside 3- Kaempferol- rutinoside) 3-o- (quercetin- Rutin acid; caffeoylquinic 4-o- and acid) caffeoylquinic (5-o- genicacid neochloro- isomers its and acid Chlorogenic oyhnl [70] Polyphenols ykwk n Tsibranska and Tylkowski eoeyaddi- and recovery 5,71] [50, 9 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 2]VlceaI,Kmhra C i F hl ,Lvnso G eodpliie rslne oyezmdzl ebae o organic for membranes polybenzimidazole crosslinked polyimide: Beyond AG. Livingston Y, (PASS) Bhole JF, sulfone Kim sulfide SC, polyarylene Kumbharkar asymmetric IB, Valtcheva of [22] characterization and Preparation al. et J, Yang K, Pan L, Li Y, Wang X, Wang mem- L, nanofiltration Liu composite [21] solvent-resistant polypyrrole-based of performance the Tuning Z. Guo J, Ma Z, Wang X, Cheng L, Shao [20] promi- of investigations systematic through membranes nanofiltration PES Tailoring NR. Tan G, Ruan SS, Hosseini solvent in MAA, Shahmirzadi use potential [19] for membrane polyphenylsulfone Novel al. et J, P, Degreve Luis E, Tocci F, Tasselli JC, Jansen S, Darvishmanesh [18] solvent and solution casting in concentration polymer of Influence AF. Ismail WJ, Lau NAA, Sani Membr [17] J membranes. ultrafiltration polyacrylonitrile from membranes nanofiltration of Preparation J. Economy JS, Ince Z, Yue J, Wang [16] membrane nanocomposite film thin UZM-5/polyamide of characterization and Preparation S. Davari M, Pakizeh M, Namvar-Mahboub nanofiltration solvent [15] organic high-performance toward strategy modification monoamine novel A L. Shao J, Long XQ, Cheng organic YC, for Xu membranes [14] polyimide of performance on parameters formation membrane of effect The AG. Livingston Mater. M, Hazard Sairam J I, Soroko techniques. separation [13] membrane by wastewaters mill olive of Fractionation E. Drioli L, Giorno C, by Conidi wastewaters A, mill olive Cassano from [12] polyphenols of concentration and Recovery E. Drioli C, Conidi A, Criscuoli A, Cassano polyphenols E, and Garcia-Castello polysaccharides [11] weight molecular low of recovery the for Nanofiltration MN. Pinho de polysac- AM, of Bernardes recovery A, the Giacobbo for [10] process based Ultrafiltration MN. Pinho de AM, Bernardes HMC, Mira ECNF, Duarte M, Oliveira A, sol- Giacobbo and [9] approach cascade through processes membrane of sustainability the Increasing AG. Livingston IB, Valtcheva G, Székely JF, Kim [8] opportunities of viewpoint a by-products: agricultural from nutraceuticals of production the for technologies Nutr. Emerging Sci CM. Food Rev Galanakis Crit [7] review. a processing: juice vegetable and fruit in 2014;92:161 separation Process. membrane Bioprod Food of Application processing. VS. food Satyavir the SA, in Ilame technology [6] nanofiltration for applications future and Current F. Salehi [5] Chem review. critical a nanofiltration: solvent organic with separation Molecular AG. Livingston GY, Szekely MFJ, Adv P, Solomon membranes. Marchetti nanofiltration [4] solvent-resistant polymeric in advances Recent L. YP, Shao Bai ZH, Guo ZX, Wang YL, Zhang XQ, Cheng [3] 2008;37:365 Rev. Soc Chem level. molecular a on separating nanofiltration: resistant Solvent IFJ. Vankelecom LEM, P, Gevers mem- Vandezande nanofiltration [2] resistant solvent of Performance B. Bruggen der van J, P, Degreve Luis J, Vanneste L, Firoozpour S, Darvishmanesh [1] References ACCIÓ, Catalonia, of Government the of authors. Competitiveness the Business by (TECNIOspring acknowledged for 600388 gratefully no. Agency are Framework agreement which the Seventh grant from Marie REA the under Incoming and of (FP7/2007-2013) as Actions) programme), Union well atthe Fund Curies European as (Marie the 07/11/15.12.2016, Programme of Science DN People Programme the National No from Contract fellowship from: Science, TECNIOspring supports and Curie financial Education with of projects Ministry the Bulgarian under prepared was chapter This Funding 978-3-11-046828-1. isbn (2017), Gruyter De Engineering. Polymer Tylkowski, in: available also is article This Acknowledgment 10 membranes nanofiltration solvent organic imprinted Molecularly AG. Livingston JF, Kim IB, Valtcheva G, Szekely [23] ovn aolrto ON nhrhevrnet.JMmrSi 2014;457:62 Sci. Membr J environments. harsh in (OSN) nanofiltration solvent 2014;132:11 Lett. Mater membranes. nanofiltration solvent-resistant 2014;452:82 Sci. Membr J oxide. grapheme incorporating and conditions polymerization optimizing by branes 2015;5:49080 Adv. RSC parameters. operational and fabrication design, nent 2011;379:60 Sci. Membr J nanofiltration. 2006;286:333 Sci. 2014;459:22 Sci. Membr J recovery. solvent dewaxing for 2016;497:77 Sci. Membr J separations. molecular sustainable for membrane (OSN) 2011;381:172 Sci. Membr J characteristics. polyimide of Effect C. Part (OSN). nanofiltration solvent 2013;248 2010;44:3883 Res. Water system. membrane integrated 2013;48:2524 Technol. Sci Sep effluents. winery from 2013;48:438 Technol. Sci Sep effluents. winery from polyphenols and charides recovery vent 2013;91:575 Process. Bioprod Food challenges. and 2015;55(7):964 10735 2014;114 Rev. E1-E24. 2014;33(S1) Technol. Polymer 405. 2011;13:3476 Chem. Green simulation. and experiments industry: pharmaceutical the in solvent residual of purification for branes omneo oyhnlufn PS)nnfitainmmrn nachlslet.JPlmEg 2014;34:489 Eng. Polym J solvents. alcohol in membrane nanofiltration (PPSU) polyphenylsulfone of formance eonto n ouerjcinbhvo.RatFntPlm 2015;86:215 Polym. Funct React behavior. rejection solute and recognition ykwk n Tsibranska and Tylkowski – 249:185 – – hraetclprfiaincs td.GenCe.2014;16:133 Chem. Green study. case purification pharmaceutical 987. – – 341. − 193. 10806. – 68. – 579. – 2530. – – 3892. 32. – 14. – 224. – – – 49097. 444. 72. – 145. – 89. – solute – 182. – ebaeitrcin nper- on interactions membrane – – 89. 500. – eeln molecular revealing EGRUYTER DE – 177. – 3483. – Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 5]Bla ,Sra .Itgae ebaepoesfrprfiainadcnetaino qeu yyimcmn L)se xrc.Food extract. seed (L.) cumini Syzygium aqueous of concentration and purification for process membrane Integrated B. dis- Sarkar electrical U, voltage Balyan high [54] by seeds grape from extraction polyphenols of Intensification JL. Lanoisellé R, Savoire E, Vorobiev D, Liu [53] low using production: membrane improved Towards A. Livingston L, Peeva J, Burgal Silva da mem- [52] nanofiltration polyimide resistant solvent of preparation the for route friendly Environmentally A. Livingston Y, Bhole Sci I, extracts. Soroko plant [51] from flavonoids and polyphenols of nanofiltration in behavior rejection and Flux B. Tylkowski I, Saykova cross- I, Tsibranska and [50] dead-end of comparison nanofiltration: by L. ssp. Sideritis from extracts ethanolic of Concentration B. Tylkowski I, Tsibranska Sideritis [49] from extracted compounds active biologically of Concentration M. Giamberini G, Peev R, nanofil- Kochanov by I, Tsibranska extracts B, of Tylkowski concentration [48] and balm lemon from acid rosmarinic of extraction Solvent G. Angelov D, P, Peshev Penchev G, Peev [47] from nanofiltration: solvent organic of assessment Sustainability AG. Livingston JF, P, Kim Marchetti MF, Jimenez-Solomon Food G, nanofiltration. Szekely by [46] brines artichoke from compounds bioactive of Recovery L. Giorno F, Peterlongo G, Mombelli W, Cabri the A, in membranes Cassano nanofiltration [45] and osmosis reverse of Performance RA. Machado VG, Mata AE, Rodrigues PF, Oliveira de A, Donelian Membr [44] J nanofiltration. by propolis from extracted compounds active biologically of Fractionation B. Tylkowski GA, Peev milled IH, Tsibranska defatted [43] from extracts polyphenolic of fractionation for sequences Membrane JL. Cabezas S, con- Beltrán the G, in Salazar ph B, and Santamaría pressure [42] temperature, of effects the and extracts propolis aqueous of Nanofiltration M. Hubinger J, through Petrus B, extracts Mello propolis [41] ethanolic and aqueous in compounds phenolic and flavonoids of Concentration M. Hubinger J, Petrus B, and Mello propolis [40] from compounds active biologically of Extraction A. Nikolova G, Peev M, Giamberini V, Bankova B, Trusheva B, Tylkowski roselle [39] from anthocyanins concentrate to membranes nanofiltration and ultrafiltration Selecting M. Dornier D, Pallet of F, Vaillant extracts M, antioxidant Cissé of [38] concentration for nanofiltration solvent organic of Application A. Boam I, Baptista G, Peev L, Peeva D, Peshev Trends[37] nanofiltration. of border the to ultrafiltration from micromolecules: and macromolecules functional of Separation CM. Galanakis [36] 11): (Chapter (DOI operations. membrane integrated by polyphenols 2015;44(2):157 Rev. of Pur Concentration B. Sep Tylkowski industry. I, Tsibranska pharmaceutical [35] in nanofiltration solvent Organic J. Bae Manag. Env MG, J Buonomenna water. waste [34] oil olive for application membrane matrix Mixed M. Peyravi M, Jahanshahi A, Rahimpour A, Zirehpour [33] membranes: framework organic polymer/metal hybrid of Fabrication AG. Livingston DC, RP, Braddock Davies G, Szekely J, Campbell [32] polymer/metal hybrid of permeance the organic Improving in AG. application Livingston potential DC, for RP, Braddock MIL-53(Al) Davies J, containing Campbell membranes [31] matrix Mixed al. et C, Gaob L, Xue J, Shen H, Zhang H, Yu Sci. L, Membr Zhu J [30] nanofiltration. solvent organic for membranes matrix Mixed AG. Livingston LG, Peeva Y, Bhole E, Rundquist H, Siddique [29] solvent-resistant for membrane improved an as (PDMS) polydimethylsiloxane filled Zeolite PA. Jacobs IFJ, Vankelecom LEM, Gevers [28] inorganic impregnated Nano-ZnO PK. Tewaria RC, Bindala A, Singhal TK, Dey A, nanofil- Pal solvent organic [27] polyimide crosslinked of performance and morphology on nanoparticles TiO2 of Impact A. Livingston I, Soroko [26] copper- with incorporated membrane (SRNF) nanofiltration resistant solvent Polyphenylsulfone-based AF. Ismail WJ, Lau NAA, Sani [25] analysis (OSN): nanofiltration solvent organic for membranes polybenzimidazole Crosslinked AG. P, Livingston Marchetti IB, Valtcheva [24] GRUYTER DE ipo rcs.2016;98:29 Process. Bioprod 2011;81(2):134 Technol. Pur Sep ultrafiltration. dead-end by concentration extract and charges 2016;18:2374 Chem Green membranes. nanofiltration PEEK 2011;13:162 Chem. Green branes. 2015;LXII:514 Technol. Food of Univ. Works 2013;91(2):169 Process. Bioprod Food modes. flow 2011;89(4):307 Process. Bioprod Food nanofiltration. by L. ssp. 2011;89(11):2236 Des. Res Eng Chem dioxide. carbon supercritical by pre-treatment plant of effect tration: 2014;16:4440 Chem. Green application. to fabrication 2016;98:257 Process. Bioprod 2016;107:639 Fluids. Supercrit J oil. essential patchouli of retention and fractionation . 1:2012;2011 Technol. Sci 2002;148(1):103 Desalination. seeds. grape 2013;1(4):55 (SCPT). Technol Chem Stud product. centrated 2010;96(4):533 Eng. 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Membr J parameters. reaction of effects and mechanism reaction crosslinking of – – – 9674. 120. 366. – 294. – – – 43. 63. 265. – 168. – – – 539. 518. 109. – 73076. – 174. – – – – eeomn fMFti lsvaitrailsnhss ae hmA. Chem Mater J synthesis. interfacial via films thin MOF of development 2502. 4473. 198. – – 65. – 2384. – 2614. 314. – – 327. 130. – 9271. – – oye yrdtifimnncmoienanofil- nanocomposite thinfilm hybrid polymer 648. – oiiyslet o h rprto of preparation the for solvents toxicity – 140. – 579. – 13010. – ykwk n Tsibranska and Tylkowski rai rmwr (MOF) framework organic – 2243. – 182. – 34151. 11 Automatically generated rough PDF by ProofCheck from River Valley Technologies Ltd 7]Tirnk ,Krbjkv ,JlakvJ ocnrto ffaood nehnlcetat rmtbcolae hog nanofiltration. through leaves tobacco from extracts ethanolic in flavonoids of Concentration J. Jeliazkov V, Karabojikova resis- I, bark: Tsibranska globulus [71] Eucalyptus of extract ethanol/water of Ultrafiltration AE. Rodrigues JM, Loureiro IF, Mota Eng. PCR, Food Pinto J EA, I. Baptista part [70] solvents: organic in tea green of components bioactive of extraction membrane on studies Novel V. Nwuha from[69] compounds phenolic of nanofiltration and extraction assisted Ultrasound MD. Hubinger J, Martínez MT, by Machado extracts RS, capitatus Rabelo Thymus [68] from polyphenols antioxidant of Concentration A. Hellal Noureddine E, Ferjani Y, Attia E, through Khelifi concentration S, Achour and [67] seeds cocoa from polyphenols of Extraction A. Bolzan TR, Tamanini JC, Petrus RA, Machado LA, Sarmento [66] resin and filtration membrane extraction, solvent through compounds phenolic marc grape of Purification pro- CA. DP, ultrafiltration Paraskeva by Zagklis concentrated [65] extracts L. album viscum and officinalis salvia of activities Res Antiradical Food GL. pulp. Radu persimmon E, from GP, Neagu tannin Roman of [64] activity antioxidant and features Structural QH. Wan MH, Chen WF, Hu YJ, Xu CM, Li HF, by Gu concentration [63] and coggygria Cotinus from compounds flavonoid and phenolic of extraction liquid Solid E. antioxi- Simeonov V, natural Koleva Camb.) [62] brasiliense (Caryocar pequi of extraction aqueous and alcoholic of Study MD. Hubinger BC, Mello MT, mem- Machado nanofiltration [61] through oleuropein of properties Transport M. Nakajima S, Sayadi H, Isoda H, Nabetani MA, Neves I, by Danmark residue [60] beer and leaves chestnut in composition phenolic of Characterization JM. Lorenzo MA, Trindade D, Franco PES, ex- Munekata aqueous [59] leaves sativa Castanea from antioxidants of concentration Membrane JC. Parajó H, Domínguez A, Moure B, Dias-Reinoso the [58] and nanofiltration by isoflavones soybean of Concentration JCC. Petrus K, Rezzadori JMG, Mandarino com- ES, Prudêncio phenolic S, of Benedetti Concentration [57] al. et M, Maraschin L, Zanotta Moraes de ER, Amante ES, Prudêncio RDC, Amboni ANN, Murakami [56] ac- antioxidant and composition Phenolic al. et JCC, Petrus M, Maraschin ANN, Murakami RDC, Amboni ES, Prudêncio APA, Prudêncio [55] 12 ugCe omn2016;48(4):232. Commun Chem Bulg 2015;144:256 Technol. Pur Sep analysis. up build cake and tance 2000;44(4):233 2016;178:170 Eng. Food J wastes. solid artichoke C703-C709. 2012;77(6) Sci. Food J technology. process membrane 2008;45(1):64 Fluids. Supercrit J membranes. polymeric 2015;156:328 Technol. Pur Sep adsorption/desorption. 2009;8(3):47 Aliment. Technol Pol Sci Acta cess. 2008;41(2):208 Int. 2015;28(4):545 Quart. Eng Biochem Chem nanofiltration. 2013;117(4):450 Eng. Food J nanofiltration. by concentration extracts and dants 2015;94:342 Process. Bioprod Food branes. 2016;68:52 Technol. Sci Food LC-DAD-ESI-MS. LWT 2011;175:95 J. Eng Chem tracts. 2013;50(2):625 Int. Res Food concentrate. the on treatments thermal of effects 2011;44(10):2211 Technol. Sci Food LWT nanofiltration. through extract Hil) St. A. paraguariensis (Ilex mate aqueous in pounds nanofil- by concentrated harvesting bark Hil.) St. paraguariensis (Ilex 2012;90(3):399 tree Process. mate Bioprod from Food residues tration. from bark of extract aqueous the of tivity ykwk n Tsibranska and Tylkowski – 238. – 217. – 102. – 353. – 405. – – 58. 180. – 58. – 335. – – 69. 551. – 266. – – 632. 457. EGRUYTER DE – 2216.