FALL 2008 VOLUME 6.2 Anesthesia News A publication of UCSF Department of Anesthesia and Perioperative Care

Special Anniversary Edition Featured Inside

Department, 2008

3 Information about 50th Anniversary Events

4 Narrative History of the UCSF Department of Anesthesia and Perioperative Care

24 Faculty Honors, Awards & Appointments

26 New Faculty

27 Academic Department Chairs from UCSF

28 UCSF Anesthesia Residents, Class of 2011

29 Stuart C. Cullen and William K. Hamilton Awardees

30 Research Faculty Spotlight

Department, 1962 32 Peer Reviewed Publications 2007-2008

38 Active Research Grants

Timeline of Sentinel First 3-Function Contributions NIH Training Grant Blood Gas Analyzer Affi liation with East Bay Stuart C. Cullen John Severinghaus Children’s Hospital 1958 Stuart C. Cullen Ernie Guy Chairs, Chiefs, Chair, 1958 Chief, SFGH, 1959 Dean, UCSF Medical School, 1966 and Directors

2 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Information about 50th Anniversary Events

UCSF Department of Anesthesia and Perioperative Care celebrates its 50th Anniversary

To commemorate its fi rst fi fty years as one of the leading anesthesia departments in the world,

the UCSF Department of Anesthesia will host a week long series of events in San Francisco,

from November 10 – 15, 2008

50th Anniversary Schedule of Events Saturday, November 15: Symposium Monday, November 10 – Wednesday, November 13: Mission Bay Conference Center, Open House Events Robertson Auditorium, 7 am – 4 pm Please join us in celebrating our 50th Anniversary! CME Credits are available. Department of Anesthesia and Perioperative Care staff The Saturday symposium will be a moderated discus- and faculty are invited to attend, as well as members of sion featuring some of the department’s past and the broader UCSF community, who have contributed to present leaders, as well as national and international the growth and success of our department. Beverages luminaries. Sessions will highlight many of the ground- and light fare will be served. The Department Chair, Dr. breaking events in research, education, and clinical Ronald Miller, will attend and provide opening remarks. care at UCSF – and beyond – and will also look to the • Monday, November 10, 3 – 5 pm — San Francisco future of anesthesia. General Hospital, Conference Room 2A6, Main Hospital, 2nd Floor Alumni Gala Reception and Dinner • Wednesday, November 12, 12 – 2 pm — Moffi tt- By invitation only Long/Mt. Zion, Millberry Union, Parnassus Campus Palace Hotel, Garden Court and Grand Ballroom, 6 pm • Wednesday, November 12, 3 – 5 pm — Veteran’s For more information, please go to the website at Administration Hospital, Director’s Conference Room http://www.anesthesia.ucsf.edu

Discovery of Central Chemoreceptor Invented MAC Respiratory Control Robert Mitchell Edmond Eger and High Altitude (Loeschke HH, Severinghaus J) (Merkel G, Saidman L, Severinghaus J) John Severinghaus 1962 1964 Sol Shnider Morley Singer Neri Guadagni Director, Obstetrical Anesthesia, 1962 1st Director, ICU Moffi tt, 1964 Interim Chair, 1966-67

ANESTHESIA NEWS 3 Featured Inside THE Birth of a Department

On September 4, 1957, Julius Comroe

arrived in Iowa City. The formal reason

was a meeting of the American

Physiologic Society, but Comroe, the

newly appointed director of the planned

Cardiovascular Research Institute (CVRI)

at UCSF, had other things on his mind.

Stuart C. Cullen, Demo

Timeline of Sentinel First Anesthesia Faculty with Joint Appointment in Contributions Department of Pharmacology Anesthetic Effects in Fetal Lamb Model Walter Way Sol Shnider 1964 William K. Hamilton Joe Lee Chairs, Chiefs, Chair, 1967 1st Director, ICU, SFGH, 1967 Associate Dean for House Staff Affairs, UCSF, 1973 and Directors

4 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE t the time, anesthesia at members Neri Guadagni and Frank stream of remarkable contributions UCSF was a small division DeBon; Earnest Guy, who was to medical care and patient safety. Ain the Department of brought on as the chief of anesthe- Much of this growth and Surgery, with few resources or sia at San Francisco General achievement is attributable to responsibilities and no research Hospital; and a new resident, stable and visionary leadership. program. Comroe – who had been Walter “Skip” Way. Since 1958, the department has recruited to UCSF as part of an It was the birth of a department known only three chairs – Cullen, effort to transform what was widely that over the next fi fty years would William Hamilton, and Ronald regarded as a third-rate medical be at the heart of modern anesthe- Miller. Perhaps their most impres- school into a truly respected center sia’s explosive growth, a depart- sive, collective achievement is that of academic medicine – believed ment that to this day continues to while managing staggering growth that the emerging discipline of have an enormous impact on and balancing clinical, research, anesthesia could play an important surgical practice and the manage- and educational demands, they role both in enhancing UCSF’s ment of pain. The department’s have never sacrifi ced the depart- reputation and helping the CVRI research, education, and clinical ment’s sense of collegiality and establish itself as a vital resource care quickly earned and have mutual respect. and training vehicle for researchers maintained reputations that are the Through a series of verbal and across the UCSF campus. equal or better of any institution in visual snapshots, this edition of the The chair at Iowa, Stuart Cullen, the world. Its faculty, fellows, and newsletter attempts to tell the had built an impressive academic residents have produced a steady department’s story. department. Cullen and Comroe met that day; by the end of the meeting, Comroe had asked Cullen to lead anesthesia at UCSF. “This has been the era of modern anesthesia. Until the 1940’s, few physicians were Cullen was intrigued – he relished anesthetists; this was a limited specialty with primitive techniques and a slight the opportunity to improve upon what he had achieved at Iowa – body of knowledge. But then this change occurred. New drugs and techniques were but wouldn’t agree to go unless developed to induce anesthesia, support breathing, relax muscles, and suppress pain. Comroe could guarantee that anesthesia would have its own Technology improved. Suddenly we had ventilators, ECG and anesthetic/respira- department, separate from surgery. tory gas monitors, the blood gas analyzer. All these made anesthesia safer – and Within hours, Comroe convinced UCSF to meet the demand. When more expensive. Knowledge that forms the underpinning of any specialty grew. The Cullen called John Severinghaus information came in a few basic forms: we measured everything affected by anes- (who had just completed an anesthesia residency with Cullen) thetics - breathing, kidney function, cardiovascular function.” with the news, Severinghaus immediately agreed to join Cullen – Edmond Eger at UCSF. Among their initial colleagues were existing faculty

NIH Center Grant VAH Affi liation with William K. Hamilton Department of Anesthesia 1969 1972 H. Barrie Fairley Richard Schlobohm George Gregory C. Philip Larson Chief, VAH, 1969 Director ICU, SFGH, 1970 Director, ICU Moffi tt, 1972 Chief, SFGH, 1972 Chief, SFGH, 1973

ANESTHESIA NEWS 5 The Birth of a Department THE Cullen Years 1958-1967

By all accounts, Stuart Cullen was a visionary The offer to

come to UCSF presented him with an opportunity to not

just repeat, but to surpass what he had built at Iowa.

How could he refuse?

ith the help and support While applying for residency of Julius Comroe and his programs, Ron Miller recalls WCardiovascular Research attending the Saturday morning Institute (CVRI), Cullen proved rounds that Cullen had established remarkably adept at securing upon his arrival. The prime funding, attracting talent, and educational event of the depart- initiating a research tradition that ment, the rounds were inviolate, would create an enduring list of something that had earned the historic contributions. Along with deep respect of the hospital’s Severinghaus, Guy, and Way, surgeons. “I sat in the back of the during his tenure Cullen would also room and watched residents and hire future luminaries that included staff openly questioning Cullen’s Edmond Eger, Ed Munson, Rudolf opinion…something he obviously deJong, and Sol Shnider. But it invited,” says Miller. “It helped me wasn’t merely Cullen’s powerful decide that UCSF was where I infl uence in a specialty poised to wanted to be.” Stuart C. Cullen, MD and Ronald D. Miller, MD explode that drew the best and Stu Cullen’s vision – his spirit the brightest, it was his personal of open exploration, political charm, his commitment to doing savvy, and unwavering commit- things right, and his remarkably ment to excellence – are the open mind. department’s birthmark.

Timeline of Sentinel Complications and Coagulation Defects Contributions associated with Massive Blood Transfusion Anesthetic Uptake and Action 1st Edition Ronald D. Miller Edmond Eger 1973 Robert Hickey Gershon Levinson Hillary Don Chairs, Chiefs, Chief, VAH, 1973 Director, Obstetrical Anesthesia, Director, ICU, Moffi tt; SFGH, 1974 Director, Respiratory Therapy, 1974 and Directors

6 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE The Master Tinkerer and of respiratory physiologists that the Blood-Gas Analyzer Severinghaus convened, a liver enzyme chemist named Leland John Severinghaus was originally a Clark pulled from his pocket a physicist who had spent the latter polarographic O2 electrode with part of World War II designing a polyethylene membrane. Within radar. It was only after the war that days, Severinghaus had begun the he turned his attention to medi- design of a water bath containing cine, receiving his MD from the PCO2 and PO2 electrodes, Columbia and, in 1952, beginning with a stirred cuvette for the Clark an anesthesia residency at the electrode. “Clark’s electrode was University of Pennsylvania. the key discovery,” says Severing- At Penn, a portable paramag- haus. “Fifty years later, every blood netic oxygen analyzer fascinated gas analyzer contains a Clark type the man his friend Ted Eger calls electrode.” “a master tinkerer.” Using himself Finally, shortly after arriving at as “human servo” he measured UCSF and with the help of his the uptake of nitrous oxide at the friend and colleague Freeman beginning of an anesthetic, Bradley, Severinghaus added a pH keeping the oxygen at 20% and electrode to this evolving device, closed system volume constant creating the fi rst three-function using fl ow meters. It was the fi rst blood gas analyzer. By 1960, he measurement of the uptake of had built and installed a clinical an anesthetic in a human, a blood-gas analyzer in the Moffi t modest beginning to a crucial Hospital OR Suite. medical advance. “I initially failed to foresee the Two years later at a conference, immense clinical potential of blood Stuart C. Cullen, MD Severinghaus heard physiological gas analysis,” says Severinghaus, chemist Richard Stow, describe a who developed it for his laboratory carbon dioxide electrode he had pulmonary studies. Yet because of Discovering and developed, but could not stabilize. the way it allows physicians to Exploring the Brain’s “A few days later, I built a Stow safely monitor heavily sedated or Carbon Dioxide Sensor type CO2 electrode using a bulb ventilated patients, today no type Beckman pH electrode, a operating room goes without the Over the years, the Severinghaus silver wire with an AgCl coat, and device. His original three-function lab became a virtual petri dish for a rubber glove membrane. My analyzer resides in the Smithsonian leading researchers and important contribution was pretty simple,” as part of an exhibit on the research. Internist Robert Mitchell says Severinghaus. “Add soda.” conquest of pain. joined the lab in 1958 and would The next step came in early share the space for the next 1956, when at an informal meeting thirty-two years.

CPAP for Neonatal Respiratory Distress Syndrome 1st Stuart C. Cullen Visiting Professor Pharmocology of Neuromuscular George Gregory (Robert Dripps) and Annual Dinner Blockade and Reversal (Kitterman JH, Phibbs RH, Tooley WH, Hamilton WK) Robert Dripps Ronald D. Miller 1974 1978 Robert Willenkin George Gregory Phillipa Newfi eld William K. Hamilton Director, Resident Education, 1974 Director, Pediatric Anesthesia, 1975 Director, Neuroanesthesia, 1977 Chief of Medical Staff, Director, Medical Student Clerkship, 1975 UCSF Medical Center, 1978 The Birth of a Department

Mitchell’s greatest contribution was his discovery, That bottle of halopropane would prove useless as with Hans Loeschke, of the medullary area that an anesthetic, but it was the perfect vehicle for Eger to regulates blood PCO2, keeping spinal fl uid pH learn how to compare one anesthetic to another. This constant. Today, when patients with conditions like led to his discovery of minimum alveolar concentration COPD have abnormal CO2 levels, the results are (MAC). In parallel, he enlarged his research on uptake understood in the context of Mitchell’s chemoreceptors. and distribution. The work on MAC and pharmacoki- That fi nding also “promised to explain a physiologic netics, which continues to this day, is unparalleled in its mystery,” says Severinghaus. “Why is it that people contribution to understanding inhaled anesthetics’ acclimatized to high altitude continue to over-breathe effect on all aspects of human physiology: breathing, for days after descending?” circulation, cerebral function, neuromuscular control, To answer that question, Severinghaus, Mitchell and and kidney and liver well-being. It is Eger’s work that two colleagues piled in a car and made their way to enables clinicians to understand how much anesthesia UC’s Barcroft Lab in the White Mountain range, east of is required to safely do the job. the Sierras. They lugged a blood-gas analyzer up there and volunteered to have their own spinal fl uid tapped. What they found was the fi rst confi rmation that rapid changes of cerebrospinal fl uid acid-base explain the mysteries of acclimatization.

The Big MAC

Ted Eger fi rst became interested in the uptake and distribution of inhaled anesthetics after hearing a talk by John Severinghaus when both were still at Iowa. He spent an hour afterwards arguing with Severinghaus, telling him he surely was wrong (he wasn’t). Later, during a stint in the Army, Eger devised a handwritten iterative equation on how anesthetics move into the lungs and tissues of the body. Anxious to continue his work in this area, in 1960 he arrived at UCSF to become a fellow in the Severinghaus lab. At the time, various drug companies were compet- ing to improve upon halothane, which had revolution- ized anesthesia. One day in Severinghaus’s small, cramped lab overfl owing with experiments of different kinds, Severinghaus handed Eger a bottle of some- thing called halopropane. “He asked me to fi nd out if it was any good,” says Eger. “And when I asked him how, exactly, he shrugged and told me I would fi gure it out.”

Stuart C. Cullen, MD

Timeline of Sentinel Optimum PEEP in Acute Pulmonary Failure Contributions H. Barrie Fairley (Suter P, Eisenberg M) SFGH Opens New Facility 1979 H. Barrie Fairley Michael Roizen George Gregory Chairs, Chiefs, Associate Dean, SFGH, 1979 Director, Vascular Anesthesia; 1st Director, Pediatric ICU, 1980 Director, PACU, 1979 and Directors

8 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE When Stuart Cullen moved from anesthesia to become Dean

of the UCSF School of Medicine, he recruited the same man

who had replaced him at Iowa to take his place at the UCSF

Department of Anesthesia. William “Bill” Hamilton proved to William K. Hamilton, MD be a wise choice. THE Hamilton Years 1967-1983

hen he arrived at UCSF, factor, and under Hamilton’s and, with the help of Sol Shnider, Hamilton understood leadership the research fi rsts kept established a very close relation- Wwhat a powerful jump coming and the money kept ship with the department of start Cullen (and Comroe) had fl owing. Hamilton believed that the obstetrics. His charm, infl uence in provided to the department and to next step was to enhance the the fi eld, and startling intelligence the entire School of Medicine. In department’s clinical work and its also proved remarkably effective at just ten short years, as the educational offerings. attracting top-notch talent and at specialty of anesthesia grew, UCSF Over the next 16 years, he placing people on projects and had begun a parallel ascent to the improved operating room cover- collaborations that would yield nation’s top tier of anesthesia age, negotiated a department important advances. Perhaps most programs. Cullen’s support for agreement that balanced the important, at a time when newly research efforts were a major needs of clinicians and researchers established ICUs were not

Mass Spectrometry for Multi-Patient End-Tidal Gas Monitoring in the OR Anesthesia for Obstetrics 1st Edition Obstetrical Anesthesia Update John Severinghaus Sol Shnider Sol Shnider (Young W, Ozanne W) (Levinson G) 1983 1984 Neal Cohen William K. Hamilton Sol Shnider Samuel Hughes Director, ICU, Moffi tt; Associate Dean, Educational Affairs; Interim Chair, Director, Obstetrical Anesthesia, Director, Respiratory Therapy, 1983 Vice Dean, School of Medicine, 1983 1983-1984 SFGH, 1984 generating professional fees and “We were still small enough to do called adoring crowds, who walked other anesthesia departments that,” says Hamilton. “My wife and away smiling, but armed as well were abandoning them, Hamilton I simply continued what Dr. Cullen with new and important knowledge. had the foresight to insist that the and his wife had begun.” In fact, though his human and department maintain control of animal studies were fi rst rate, these units at UCSF. Today, most The Pied Piper Shnider’s greatest contribution hospitals have maybe one of OB Anesthesia may have been as a teacher. He board-certifi ed anesthesia-intensiv- wrote the seminal text on OB ist in critical care; UCSF has 27. After training at Columbia with anesthesia, which began as a All of this contributed to the Virginia Apgar, Sol Shnider arrived refresher course for residents. department playing an increasingly at UCSF in 1966 to begin a Eventually, the annual OB meeting important role in the overall picture division of OB Anesthesia. A giant Shnider initiated at UCSF would of the school. Hamilton believes of a personality whose social circle draw some 400-500 residents and that the department’s growth included the world’s most promi- practicing physicians from all over during his tenure made it that nent opera stars – and who the the world. much more important to maintain a department relied upon to organize “It fi lled a huge need for lots of sense of departmental camarade- and enliven its social and profes- people,” says Rosen. “The thing rie. The informal get-togethers at sional events – Shnider used about Sol is that beneath all the his home were a cherished tradition. engaging showmanship to showmanship he was very, very signifi cantly advance an important professional; he rehearsed his talks sub-specialty. – even the showy parts – down to “Sol’s contribution really was that the second and they were always Morley Singer, MD until the early 1950’s, no one paid fl awless.” attention to the impact of anesthe- sia on the fetus,” says Mark Saving Newborns in Rosen, a Shnider protégé who Respiratory Distress today is UCSF’s director of OB anesthesia. “He made the world During his time at Iowa, Bill aware of this concern.” Hamilton had been disturbed by Shnider accomplished this in a the newborns he treated who were number of ways. Although he in respiratory distress. “I could hear didn’t invent the fetal lamb model the tiny alveoli popping and I found that enabled researchers to gain a if I kept the bag tight, I could keep much better handle on how to the airway from collapsing on monitor both the fetus and the itself,” says Hamilton. At the time mother, he was one of the fi rst to 100 percent oxygen was the understand its importance. His standard gas for treating patients lectures, with their smiling sheep in respiratory distress and by cartoons and show tune accompa- maintaining pressure using pure niments, drew what could only be oxygen, says Hamilton “We found

Timeline of Sentinel Combined Transcutaneous PCO2 Contributions and PO2 Blood-Gas Electrode 1st Edition Anesthesia John Severinghaus Ronald D. Miller 1984 Ronald D. Miller Mark Rosen Jerome Strong Chairs, Chiefs, Chair, 1984 Director, PACU, 1984 Director, Medical Student Clerkship, 1984 and Directors dramatic and immediate respons- 30 percent oxygen, you could es, but the results weren’t main- keep the airways open without tainable for more than a few harming the lungs. The result was hours. It never occurred to us that Continuous Positive Airway oxygen could be the cause.” When Pressure (CPAP), which has saved he arrived at UCSF, however, he the lives of countless children in found the ideal person to solve respiratory distress. the problem. Gregory would go on to write At the time, George Gregory the defi nitive text on pediatric was in his last year of residency, anesthesia and pediatric intensive and Hamilton put him to work on care and is today recognized as devising a treatment for hyaline among the foremost authorities on membrane disease. “He was pediatric anesthesia in the world. willing, probably because George isn’t happy unless he’s underpaid, Towards the Safe Use of underfed, and overworked,” says Neuromuscular Blockade Hamilton. Working in part from fi ndings by a group in Boston One day after returning to UCSF about oxygen toxicity, Gregory – from a tour as a battlefi eld George Gregory, MD whose commitment to pediatric physician in Vietnam, Ron Miller anesthesia is legendary – con- observed Ted Eger studying the fi rmed that oxygen toxicity was real effect of isofl urane in human and soon discovered that if you volunteers. The two men spoke, increased airway pressure with and “I started monitoring neuro- muscular function in those volunteers. From there the work on the interaction of volatile

M&M with William K. Hamilton, MD

Awareness during Surgery for Major Trauma TEE Introduced into Clinical Anesthesia Anesthesia for Fetal Surgery Martin Bogetz Michael Cahalan Mark Rosen (Katz, J) (Kremer P, Schiller N) 1985 1986 Cedric Bainton Gerard Ozanne Michael Cahalan Judith Donegan Chief, SFGH, 1985 Director, Resident Education, 1985 Director, Cardiac Anesthesia, 1986 Director, Neuroanesthesia, 1986

ANESTHESIA NEWS 11 had it); it was the fi rst time that drug was brought into the US and it ended up being the dominant muscle relaxant in the world for many years,” says Miller. Through the late ‘70’s and early ‘80’s Miller published numerous pieces, including some on the original assays he developed in collaboration with Neal Castagnoli at the School of Pharmacy. These Ron Miller has a question as Claire Weenig, Terry Vitez, assays enabled physicians to Neri Guadagni and Walter Way listen measure not just the concentra- tions of muscle relaxants in the anesthetics and muscle relaxants Columbia lab, Miller conducted blood, but also their metabolites; evolved,” says Miller, who had one of the fi rst kinetic studies to they also helped UCSF become returned from Vietnam thinking he defi ne how curare was eliminated. the world’s analytical leader in the would continue doing seminal Bill Hamilton then encouraged kinetics of muscle relaxants. research he’d begun there on Miller to attend a meeting in Eventually, Miller was joined in this massive blood transfusions. London where key players who work by James Caldwell, who William Hamilton, MD Over the next thirty years, Miller were synthesizing new and better arrived from Scotland in 1986 to and the many talented residents he muscle relaxants – and a group do a one-year fellowship; he has would attract played a central role in from The Netherlands that had remained at UCSF ever since and understanding the pharmacokinetics developed a new assay for has been instrumental in facilitating and dynamics of muscle relaxants measuring pancuronium – would the breadth and depth of clinical and their antagonists. It’s an under- also be attending. Miller’s subse- research on muscle relaxants. standing critical to performing safe quent one-year sabbatical enabled “The modeling we did here anesthesia, especially today when him to conduct kinetic studies with helped to explain the areas where hospitals are doing procedures on the Holland group, and begin a you might get into trouble in the ever sicker patients. long-term collaboration with a ICU, where the drugs can accumu- One of the most powerful drivers Scottish chemist, David Savage, late over days and weeks,” says of this work was the recognition who synthesized over half of the Caldwell. The group’s lead article in that with the advent of kidney emerging drugs in the ‘70’s and the New England Journal of transplants in the 1970’s, there ‘80’s. That year may also have Medicine, with Miller as principal was an increase in post-operative contributed to Miller’s inadvertent author, was in large part respon- paralysis. This led Miller to work interlude as an international “drug sible for reductions in the inappro- with a researcher at Columbia smuggler.” priate use of these drugs in the University (Matteo) who had “I recall getting on an airplane intensive care setting. developed a radio-immunoassay with a plastic bag that contained for curare. With the help of Matteo’s vecuronium (without revealing he

Timeline of Sentinel Contributions Pediatric Anesthesia 1st Edition Long Hospital Opens George Gregory 19851987 Martin Bogetz Warren McKay Chairs, Chiefs, 1st Director, Ambulatory Surgery Center, 1987 Director, Pain Management Center,1987 and Directors

12 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE SFGH Hosts Level respect for his residents that he One Trauma and… often consulted with them about Steve McQueen the in-progress building plans. Ron Miller recalls that it was during one When Dick Barber arrived in San such consultation that residents Francisco in 1967, the anesthesia suggested the elevators be made faculty at San Francisco General bigger so as to make it easier to Hospital (SFGH) “was a small, congenial group of three: Earnest P. Guy, Robert Hudson Smith, and myself,” says Barber. “The eight operating rooms were without piped gases or vacuum. Huge ‘G’ cylinders of nitrous oxide and oxygen were mounted on the backside of the anesthesia William Hamilton, MD machines.” It was a busy time. SFGH was the only level one trauma center for the city, so anesthesia and all surgical specialties were in house 24 hours a day, seven days a week, 365 days a year. “We were all so busy with too many patients for too few faculty, residents and outdated equipment to appreciate the steady increases in staffi ng, equipment, and general support from the city which culminated in the mid ‘70’s with the opening of the superbly equipped, brand new multi-million dollar hospital we so badly needed,” says Barber. The new hospital enabled Barber and his colleagues to continue their critically important work for a mostly underserved population. One interesting note was that Guy, who was chief at SFGH during much of this time, had such

Cerebral Hypoxia and Brain Metabolism Changing Practice of Anesthesia, Lawrence Litt Annual Department CME Course 1988 Yung Sohn Marie Csete Robert Hickey Director, Vascular Anesthesia, 1987 Director, Liver Transplantation Director, Clinical Anesthesia, 1988 Anesthesia,1988

ANESTHESIA NEWS 13 transport patients from fl oor to the precursor to today’s critical fl oor. The change was made – and care units. has been duly appreciated by His meeting with Hamilton clinical staff ever since. “When you happened quite by chance. The look at the wide elevators at San two men shared a research and Francisco General, just remember clinical interest in respiratory why they were built so wide: Dr. inadequacy. At a New England Guy and the residents in the late meeting where Hamilton was ‘60s.” says Miller. scheduled to speak, Fairley There were many lives saved appeared as an unscheduled and many rewards in Barber’s replacement speaker. Hamilton 12-year stay at SFGH (“the very wasted no time in recruiting him. best of my professional life,” he Fairley arrived at UCSF in early says), but one reward was quite 1969, but had yet to obtain a unexpected. In 1969, the ICU head California license. Knowing that nurse called Barber up to Ward 34 Fairley could practice on federal where a fi lm team was doing a territory and that UCSF would be “Code Blue scene” for the Steve taking over the anesthesia service McQueen movie, Bullitt. At fi rst at the San Francisco Veteran’s dismissive of leaving his clinical Administration Hospital, Hamilton duties for show business, Barber made Fairley that facility’s fi rst eventually relented. He spent the UCSF chief. next few days working with the The department’s infl uence at Hollywood stars, speaking a few the VA grew quickly under Fairley: lines, and joining the Screen Actors it took over intensive care, and for Ernie Guy takes apart a Bird Mark 7 to teach Terry Vitez Guild. “It was a good movie the fi rst time placed residents there and Mike Baker its function despite my total lack of acting who quickly established them- talent,” says Barber. “I didn’t quit selves as the in-house on-call my day job.” physicians. Fairley also set the foundations for a VA research On to the VA program in anesthesia. Later, after a year at the Moffi t Hospital, he Barrie Fairley represents one of would become chief at San the most important recruiting Francisco General for twelve years coups during the Hamilton era. and was appointed Associate Originally from the U.K., Fairley Dean at SFGH before assuming was a true critical care pioneer; the chair at Stanford University in the 1950s and 1960s, he had in 1985. instituted Canada’s fi rst interdisci- plinary respiratory failure units,

Timeline of Sentinel NIH-Sponsored Study of Perioperative Ischemia Contributions Oak Knoll Naval Dennis Mangano Anesthesia Residents join UCSF (London M, Leung J) 1988 Mark Rosen Jeoff Benson Chairs, Chiefs, Director, Resident Education, 1988 Director, Acute Pain Service, 1989 and Directors

14 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Department, 1980s

THE Miller Years 1983-present

After a 10 month international search, Ron Miller took over from arly on Miller called for an outside evaluation of the Bill Hamilton (and interim chair Sol Shnider) in 1984 with an Eresearch program to ensure UCSF would stay ahead of the enormous sense of responsibility to make sure the department curve. He aligned the department with the hospital’s goals, and built stayed at the forefront of the profession. To do so in a modern on the strong and respectful working relationship with surgery era fi lled with increasing regulation and intense competition, that Hamilton established. Miller also oversaw a complete revamp- Miller implemented a broad and strategic approach. The ing of the department’s fi nances, developing rigorous systems for success of that approach speaks for itself, as the UCSF professional fee billing that are still in place today. Department of Anesthesia and Perioperative Care has become In addition, he has been tirelessly responsive to external one of the largest and most prestigious in the world. change. As more anesthesia sub-specialties have emerged, in

Anesthesia Research Laboratories (4th Fl) underwritten by Anaquest, Organon, Anesthesia Research Foundation and Ambulatory Surgery Center opens Anesthesia/Pharmacology Research Foundation 1989 Brian Cason Lydia Cassorla William Shapiro Chief, VAH, 1989 Director, Preoperative (Prepare) Clinic, 1989 Director, PACU, 1989

ANESTHESIA NEWS 15 The Birth of a Department

and Sue Carlisle (Associate Dean of San Francisco General Hospital).

A Fundamentally Better Way to Monitor Patients

One day in the early 1990’s, in the Moffi t OR suite, Ron Miller rushed down the hall and said to his colleague Michael Cahalan: “We’re losing this patient; come take a look.” When they arrived, Miller showed Cahalan a septic woman whose heart rate was 150 beats per minute and systolic arterial blood pressure was 50 mmHg. Miller explained that they had already given the woman appropri- ate amounts of blood and still did not know whether the problem was hypo- or hypervolemia. Welcome Residents, 1992 Cahalan, an expert in transesopha- geal echocardiography (TEE), put a scope down the woman’s throat, the tradition of his predecessors to attract the most, the best, and revealing a nearly empty heart. Miller has continued to recruit the the brightest. This included what After they administered the best faculty and fellows in the was really the fi rst wave of appropriate fl uids intravenously, world to establish those sub-speci- prominent woman anesthesiolo- arterial blood pressure increased alities at UCSF. As changes in gists, many of whom remain and the heart slowed. The health care fi nancing and delivery leaders in their fi eld such as procedure, known as rescue echo, fostered changes in hospital stays, Pamela Palmer (leading interna- is rapidly becoming the standard Miller oversaw the establishment of tional authority in Pain Manage- for life-threatening hypotension. It adult and pediatric pre-operative ment), Kathryn Rouine-Rapp also was the culmination of a clinics, under the department’s (Director of the UCSF Prepare clinical research path that Cahalan watchful eye. Clinic), Isobel Russell (Director of had begun a decade or so before. Finally, even when there were Adult and Pediatric Cardiac In 1981, Cahalan was an brief downturns in the number of Surgery), Jeanine Wiener-Kronish assistant professor working in the applicants for anesthesia residen- (Chairperson of Anesthesia at Eger lab when Bill Hamilton asked cies nationwide, UCSF continued Massachusetts General Hospital), him to meet with a new cardiology

Timeline of Sentinel Pharmacokinetic and Pharmacodynamic Research on Intravenous Anesthetics Contributions LMA First Used at UCSF Dennis Fisher Martin Bogetz (Stanski D) 1990 Jeffrey Katz Ken Drasner Mark Rosen Chairs, Chiefs, Chief, Mount Zion, 1990 Director, Acute Pain Service, 1991 Director, Residency Program, 1991 and Directors

16 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE “We slipped the scope fellow named Peter Kramer. Under rejected. When Cahalan returned to down and suddenly, in the tutelage of Nelson Schiller and UCSF in 1986, after a sabbatical in in collaboration with an outside Europe, it was the surgeons’ real time, saw a moving engineer, Cahalan and Kramer support that convinced the hospital image of all four began working with mini-ultra- to purchase the fi rst commercial sound transducers mounted on a edition of the device. chambers of the heart. gastroscope in an effort to obtain Today Cahalan, who is now the My jaw hit the ground improved pictures of the heart. chair at the University of Utah, sits Within months, three groups on a committee about to recom- and I knew right away around the world received mend TEE for monitoring during all this was a fundamentally permission to begin testing the cardiac procedures. Anesthesiolo- devices – now with two-dimen- gists and surgeons at UCSF had better way to monitor sional transducers – on human understood its importance 25 years patients.” subjects. Cahalan, Kramer, Schiller, ahead of the curve. and Mike Roizen received their fi rst 2-D device in late 1981, while –Michael Cahalan, MD working in Moffi t’s OR-10. “We slipped the scope down and suddenly, in real time, saw a moving image of all four chambers of the heart,” says Cahalan. “My jaw hit the ground and I knew right away this was a fundamentally better way to monitor patients.” Over the next couple of years, UCSF fellows demonstrated how TEE provided a much more accurate measure of ventricular fi lling than traditional measures of ischemia. Meanwhile, the purchase of a 19’’ black and white monitor for the OR proved to be a critical “epiphany for the cardio and vascular surgeons, who saw that this could answer important questions about clinical care,” says Cahalan. Their support proved crucial, as initially TEE was considered dangerous and the papers about it were widely William Shapiro, MD and Jeffrey Katz, MD

Perioperative Thermoregulation Mount Zion Affi liation with UCSF Daniel Sessler 1991 1993 Charles Cauldwell Scott Kelley Richard Weiskopf Robert Allen Director, Medical Student Clerkship, 1992 Director, Liver Transplantation Director, Spine Anesthesia, 1992 Director, Pain Management Center, 1993 Anesthesia, 1992

ANESTHESIA NEWS 17 The Importance of Being a couple of degrees of hypotherm- “Once we started looking we Normal (thermic) ia — as is typical in unwarmed realized prevailing wisdom was surgical patients — triples the risk When he was a resident at UCLA of surgical wound infection, wrong and the consequences of in the early 1980s, Daniel Sessler signifi cantly increases blood loss hypothermia were much more found himself leafi ng through a and transfusion requirement, smattering of about thirty, mostly prolongs recovery, and lengthens severe than anyone realized. ignored articles on temperature hospital duration. Consequently, it’s now the regulation during surgery. The “Once we started looking we consensus was that perioperative realized prevailing wisdom was standard of care to keep surgical temperature regulation was well wrong and the consequences of patients normothermic.” understood and of little conse- hypothermia were much more quence except for postoperative severe than anyone realized,” says shivering. Sessler didn’t believe the Sessler. “Consequently, it’s now –Daniel Sessler, MD system was so simple and began a the standard of care to keep series of several hundred studies, surgical patients normothermic.” mostly conducted during his fi fteen years as a faculty member in the Laryngoscope Party for Graduating Residents, 1990 UCSF Department of Anesthesia Sessler’s team, today known as the Outcomes Research Consor- tium, initially focused on tempera- ture regulation. They showed that general anesthetics profoundly impair thermoregulation, but do not completely obliterate control. Instead, control re-emerges when patients became suffi ciently hypothermic. The team next addressed heat balance and showed that hypothermia develops with a characteristic three-phase pattern, with each phase having a different cause. The third major phase of the studies evaluated the consequenc- es of mild perioperative hypo- thermia. In a series of major multi-center outcome trials, Sessler and his team proved that even just

Timeline of Sentinel Management of Pulmonary Contributions Diffi cult Airway Management Workshop Pseudomonas Infection Cedric Bainton Jeanine Wiener-Kronish 1993 Toni Magorian Sandy Weitz Mark Rosen Chairs, Chiefs, Director, Medical Student Clerkship, 1993 Director, Acute Pain Service, Director, Obstetrical Anesthesia, 1993 1994 and Directors

18 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE The Studies in Perioperative Ischemia That Changed Cardiology

In the 1990’s, a group of research- ers at the San Francisco Veteran’s Administration Hospital led by Dennis Mangano recognized that anesthesia research could benefi t from the type of large, multi-center clinical trials done by cardiologists. “We began with an epidemiological study that found old, sick people did poorly in surgery. We then searched for risk factors we could modulate.” says Art Wallace, part of the original team. Jerome Strong, MD, Yung Sohn, MD, Joan Howley, MD A subsequent study found that keeping people unconscious post surgery could reduce risks, but Though the work had – and has “The question then became: how was expensive and problematic. – its skeptics, shortly after can we deliver the hemodynamic “The question then became: how implementing their beta blockade can we deliver the hemodynamic protocols with patients at the VA, stability of an anesthetic without stability of an anesthetic without the facility’s score from the National making people unconscious?” making people unconscious?” Surgical Quality Improvement says Wallace. Project (NSQIP) went from 1.0 to In a large, clinical trial, the group 0.6. Wallace soon found himself –Arthur Wallace, MD (now dubbed McSPI for Multi-Cen- being invited to various hospitals to tered Study of Perioperative talk about or set up beta blockade Ischemia), moved on to test 17 programs. Today, more than a different drugs – brand names and hundred hospitals across the generics – from beta blockers to country have adopted the McSPI Alpha 2 agonists and anesthetic protocols. Perioperative beta agents. In landmark piece of blockade in select patients has research they published in the become a level one standard New England Journal of Medicine, of care. McSPI found that the generic beta blocker atenolol was the most effective at reducing the risk of both myocardial ischemia and mortality.

Spinal Neurotoxicity of Local Anesthetics Letterman Army Pupillometry and Anesthesia Ken Drasner Anesthesia Residents join UCSF Merlin Larson 1994 Ron Vale Arthur Wallace Neal Cohen William K. Hamilton Distinguished Professor, 1994 Director, Preoperative Clinic VAH, 1994 President of Medical Staff, UCSF Medical Center, 1994-96 Fighting Bioterrorism of Defense (DOD) was interested to address multiple subtypes within enough in having an antidote on each of the A, B, and E types. Botulinum neurotoxins (BoNTs) are hand to provide some modest Moreover, unlike many diseases, the most poisonous substance funding towards discovering a single antibodies did not signifi - known to man. Though actual safer antitoxin. With a push from cantly neutralize BoNTs in vivo. “It’s botulism cases are rare, they are one of his colleagues – and impossible to achieve the required widely feared as a possible because he was expert in produc- potency unless you use a combi- biological weapon because of ing antibodies – Jim Marks began nation of antibodies that bind to their potency and the long-lasting almost casually searching for a the toxins simultaneously in paralysis they cause. safer antidote for botulism. different places,” says Marks. In 1993, the only known In particular, he began develop- Then 9/11 happened. With a treatments were antibodies derived ing monoclonal antibodies for the whole new sense of urgency and a from exposed hospital workers most common BoNTs: types A, B, dramatic increase in support from (hard to come by) and antitoxins and E. It was complicated work, the DOD, the work in the Marks lab derived from horses that have a for the antibodies not only had to accelerated. very high incidence of serious side be potent enough to cope with the His team has now produced a effects. At the time, the Department extreme toxicity, but they needed unique combination of monoclonal

Laryngoscope Party for Graduating Residents, 2008

Timeline of Sentinel Vecuronium and Prolonged Paralysis in the ICU Contributions Veronica Segredo Neuroprotection from Hypoxia (Caldwell J, Matthay M, Miller RD) Philip Bickler 1995 James Caldwell James Marks Jeanine Wiener-Kronish Chairs, Chiefs, Director, Neuroanesthesia, 1995 Director, ICU, SFGH, 1996 Director, Preoperative (Prepare) Clinic, 1996 Perioperative Medical Director, 1999 and Directors Lundy Campbell, MD, Joan Howley, MD and Cheng Quah, MD

Ronald D. Miller, MD, and Tin-Na Kan, MD, antibodies for type A, B, and E We’re Physicians First at Simulation Center BoNTs. Each type-specifi c antibody combination binds toxin One of the hallmarks of the Depart- simultaneously in three places and ment of Anesthesia has been its treatment outcomes, and genetics engages in a novel clearance collective ability to not just advance of cerebrovascular disease. mechanism that completely the discipline itself – a critically In 2000, attracted by “opportuni- removes the BoNT in one circula- important pursuit – but to advance ties to broaden the breadth and tory path. The antibodies can be the entire practice of medicine. depth of the science,” Young and used for treating acute botulism or Recruiting William Young to UCSF two of his fellows (including current as a vaccine providing protective in 2000 furthered that role. faculty member Tomoki Hashimo- levels for between six and twelve In the mid 1980’s, Young was at to) joined the UCSF Department months. The group’s fi ndings on Columbia University when he of Anesthesia and set up the combining antibodies to increase became interested in the hemody- Center for Cerebrovascular potency could be broadly appli- namics of how the brain functioned Research. His was one of the few cable to a range of pathogens and during and after cerebrovascular large research groups to be recruit- toxins. Working with a private surgery. With strong mentorship by ed from outside of UCSF. The company funded by the NIH, Columbia’s chiefs of neurosurgery center focuses on hemorrhagic Marks is now scaling up to help and stroke neurology, Young and diseases of the brain, especially manufacture an antidote to treat A, an interdisciplinary team would intracranial aneurysms and brain B, and E botulism for clinical trials study everything from the forma- arteriovenous malformations beginning in 2009. tion and regulation (AVMs). There are a wide range of of blood vessel growth to the specialities associated with the epidemiology, natural history, center, and eight of the ten core

VAH Develops Ambulatory Surgery Unit Discovery of Non-Immobilizer Arthur Wallace Donald Koblin 1995 1999 Maurice Zwass Charles Cauldwell A. Sue Carlise Director, Pediatric Anesthesia Fellowship, 1997 Director, Pediatric Anesthesia, 1998 Chief, SFGH, 1999

ANESTHESIA NEWS 21 The Birth of a Department

“Ultimately, the current status of our specialty should be an effect – not a cause – of the questions we ask. And our reach should exceed our grasp.”

–William Young, MD

Walter Way's House, September 1984

members are faculty in the who won’t? And, second, as we tive. What each of us do - this Department of Anesthesia. learn more about the molecular defi nes anesthesiology. Ultimately, Among its accomplishments, mechanisms we can develop the current status of our specialty the center was the fi rst to more effective therapies…I think should be an effect – not a cause associate human genetic we’re well on our way to develop- – of the questions we ask. And our variation with non-inherited ing pharmacological or gene reach should exceed our grasp.” ■ AVMs and to establish a link therapies that can stabilize the between common infl ammatory blood vessels to decrease the processes and disease risk of spontaneous rupture.” progression, including hemor- “Anesthesiologists are physi- rhage. “There are two main cians fi rst,” continues Young. clinical implications for our “Solving some of the critical fi ndings,” says Young. “First, questions and problems in we will be able to develop medicine involves tackling biomarkers that can help with disease causes and cures; such prognostication and risk work requires interdisciplinary stratifi cation – to rationally study, to which anesthesiologists, answer the questions: Who will as perioperative physicians, bring benefi t from intervention and a unique and important perspec-

Timeline of Sentinel Outcomes Research: Aging and Postoperative Contributions NIH Training Grant Delerium and Cognitive Decline Lawrence Litt Jacqueline Leung 1999 Pamela Palmer Neal Cohen John Feiner Chairs, Chiefs, Director, Pain Management Center, 1999 Vice Dean, UCSF, 2000 Director, Liver Transplantation Anesthesia, 2000 and Directors

22 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE with other specialties and make our unique contribution has been critically important. In the years ahead, we must expand this role. To do so will be essential not just for our own success, but also the success of this entire campus. Consider such initiatives as the new medical center at Mission Bay; a new orthopaedic institute Anesthesia Resident Match Party 2005 opening in 2009; and the 2009 opening of a new stem cell research building at the UCSF An Illustrious Past As this history makes clear, for fi fty Parnassus campus, with construc- years UCSF has been a national tion beginning in late 2008. All of and international leader in academ- these developments offer opportu- Prepares the Department ic anesthesia. We are positioned nities for groundbreaking collab- well to assume an even more orative work, from bench research prominent role in the years ahead through clinical innovation. We for a Challenging Future as academic medicine becomes must seize these opportunities. more sophisticated and more We have been successful for half central to the delivery of safe, high a century through a combination of quality care. outstanding faculty, the power of By Ronald D. Miller, MD Obviously, the gifted individuals the UCSF campus, and stable and who have staffed and led this visionary leadership. In addition to department have been the central the examples set by Stu Cullen factor in our success. Yet it’s also and Bill Hamilton, I distinctly recall important to remember that we the way Rudy Schmidt – who was have not accomplished all of this dean of the medical school when I on our own. We have always became chair – constantly pushed depended upon the rest of the me to make us a better depart- “Today, there is an increasing focus on clinical, UCSF community – the wealth of ment. I can’t say I liked it at the translational, and basic science research in the talented people across this time, but in retrospect it was an campus, from brilliant basic enormously helpful approach. In total perioperative period, including preoperative scientists to the fi nest clinicians in that spirit, I challenge those of you evaluation, intraoperative anesthesia, and the world. Whether it was the who will lead over the next fi fty CVRI, the Center for Cerebrovas- years to engage fully with this cam- critical care and pain medicine.” cular Research, or any of the other pus, to exert our leadership, and to fi ne centers and initiatives at UCSF, ensure that the tradition highlighted – Ronald D. Miller. MD anesthesia’s ability to work closely herein will continue – and grow. ■

Beta Blockade to Reduce Perioperative Mortality Dennis Mangano John Severinghaus Anesthesia Laboratory Opened (Wallace A) Radiometer 2000 Jeffrey Katz Linda Liu Renee Navarro Dorre Nicholau Director, Clinical Anesthesia, 2000 Director, Critical Care Fellowship, 2000 Perioperative Director, SFGH, 2000 Director, PACU, 2000

ANESTHESIA NEWS 23 Faculty Awards, Honors & Appointments

2008 Awards and Honors Institute of Medicine Elected Members

Helge Eilers, MD & Mark Schumacher, MD, PhD The Institute of Medicine of the National Academies Extramural Award: was chartered in 1970 to provide the nation with First Place, 2008 IARS Kosaka Abstract Session, for: science-based advice on matters of biomedical Chu C, Schumacher MA, Bunnett NW, Eilers H. science, medicine and health. The Institute’s members, Inhaled Anesthetics Activate TRPA1Heterologously elected on the basis of their professional achievement Expressed in HEK Cells. and commitment to service, serve without compensa- tion in the conduct of studies and other activities on Ronald D. Miller, MD, Chairman matters of signifi cance to health. Election to active Extramural Honors: membership is both an honor and a commitment to American Society of Anesthesiologists Distinguished serve in Institute affairs. Service Award 2008 American Society of Anesthesiologists Emery A. Ronald D. Miller, MD 1998 Rovenstine Lecturer 2008 Jeanine Wiener-Kronish, MD 2002 James Marks, MD, PhD 2006 John Severinghaus, MD, Professor Emeritus Extramural Honor: American Society of Anesthesiologists Eponymous UCSF Haile T. Debas Lecture, “John W. Severinghaus Lecture on Transla- Academy of Medical Educators tional Science” established 2008 The Haile T. Debas Academy of Medical Educators is Muhammad Shaikh, MD dedicated to creating an environment that enhances Extramural Appointment: the status of teachers of medical students at UCSF, NIH Grant Reviewer, Bioengineering Research promotes and rewards teaching excellence, fosters Group, 2007 curricular innovation, and encourages scholarship in NIH Grant Reviewer, NIH Fellowship (F-31; F-32) medical education. Members of The Haile T. Debas Biomedical Engineering and Imaging Studies, 2008 Academy of Medical Educators actively participate in the work the Academy performs in pursuit of its goal of promoting educational excellence in the UCSF community. Because of the rigor of the selection process, Academy membership is known to be a sign of outstanding performance; academy members are recognized as highly accomplished educators.

Martin Bogetz, MD 2001 Manuel Pardo, MD 2001 Harriet Hopf, MD 2004 Marek Brzezinski 2007

Timeline of Sentinel Incentive-Productivity-Based Contributions John Severinghaus Research Fellowship Compensation System Developed underwritten by Radiometer Ronald D. Miller 2000 Isobel Russell Thomas Shaughnessy Dan Swangard Chairs, Chiefs, Director, Cardiac Anesthesia, 2000 Director, Respiratory Therapy, Director, Preoperative (Prepare) Clinic, 2000 2000 and Directors

24 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE American Society ASA Annual Emery A. Rovenstine Memorial Lecture of Anesthesiologists Awards The Rovenstine Lecture is a longstanding high point of the Annual Meeting and honors Dr. Rovenstine, the ASA Award for Excellence in Research distinguished past chair of the Department of Anesthe- This award recognizes outstanding research that has siology at New York University Medical Center and had or is likely to have a major impact on the practice Director of Anesthesiology at Bellevue Hospital in New of anesthesia and/or research representing a mature York City. Dr. Rovenstine was a founding member and and sustained contribution to the extension and president of the American Board of Anesthesiology, advancement of the science of anesthesiology. ASA president in 1943-44 and the 1957 recipient of the ASA Distinguished Service Award. Because of his John W. Severinhaus, MD 1986 seminal contributions to the specialty, especially as an Edmond I. Eger, MD 1989 administrator and educator, this prestigious lectureship Daniel I. Sessler, MD 2002 was established in his name. The ASA president chooses the lecturer as part of his/her duties, and the ASA Distinguished Service Award lecture is always one of the highlights of the Annual Annually since 1945, ASA has determined whether to Meeting. bestow its most prestigious honor, the Distinguished Service Award (DSA), on a member for outstanding William K. Hamilton, MD 1978 clinical, educational or scientifi c achievement or for Ronald D. Miller, MD 2008 contributions to the specialty and/or exemplary service to ASA. The DSA is presented by the president during ASA John W. Severinghaus Lecture the ASA Annual Meeting at the time of the Emery A. on Translational Science Rovenstine Memorial Lecture to the individual selected In 2008 the ASA approved the naming of its Annual by the House of Delegates at the previous year’s Meeting Tuesday afternoon translational research Annual Meeting. The award is the ASA’s highest tribute plenary session to henceforth be known as the “John paid to an anesthesiologist for meritorious service and W. Severinghaus Lecture on Translational Science”, achievement. This will be the fi rst year in which the one of only two eponymous lectures at their annual Rovenstine Lecturer is also bestowed with the meeting. Dr. Severinghaus will give the inaugural Distinguished Service Award. lecture at the 2008 Annual Meeting.

Stuart C. Cullen, MD 1964 William K. Hamilton, MD 1986 Edmond I. Eger, MD 1991 Robert K. Stoelting, MD 2003 Ronald D. Miller, MD 2008

Developer, Perioperative Cardiac Risk Reduction Intraoperative TEE. An Interactive Text and Atlas Program at over 100 Medical Centers Michael Cahalan Arthur Wallace 2001 Pekka Talke Julin Tang Martin Bogetz Mark Grabovac Director, Neuroanesthesia, 2000 Director, Medical Student Clerkship, 2000 Director, Medical Student Clerkship, 2001 Director, Spine Anesthesia, 2001

ANESTHESIA NEWS 25 New Anesthesia Faculty

Career Faculty Residencies: Internal Medicine Jon Matthew Aldrich, MD Oregon Health Sciences University Clinical Instructor Portland, Oregon Joined Faculty August 1, 2008 Anesthesiology Medical School: Massachusetts General Hospital Stanford University School of Medicine Boston, Massachusetts Palo Alto, California Fellowship: Internship: Critical Care Medicine Surgery Massachusetts General Hospital University of California, San Francisco Boston, Massachusetts Residency: Previous Employment: Jon Matthew Aldrich, MD Anesthesiology Instructor in Anesthesia University of California, San Francisco Harvard Medical School Fellowship: Boston, Massachusetts Critical Care Medicine Assistant Professor of Anesthesia University of California, San Francisco Harvard Medical School Boston, Massachusetts Marla Ferschl, MD Marla Ferschl, MD Clinical Instructor Benjamin Houseman, MD, PhD Joined Faculty August 1, 2008 Assistant Professor in Residence Medical School: Joined Faculty January 1, 2008 University of Chicago Pritzker Advanced Degree: School of Medicine PhD, Chemistry Chicago, Illinois University of Chicago Internship: Chicago, Illinois Internal Medicine Medical School: University of Chicago University of Chicago Pritzker School of Medicine Pritzker School of Medicine Chicago, Illinois Chicago, Illinois Judith Hellman, MD Residency: Internship: Anesthesiology Resurrection Medical Center University of California, San Francisco Chicago, Illinois Residency: Judith Hellman, MD Anesthesiology Associate Professor in Residence University of California, San Francisco Joined Faculty August 1, 2008 Benjamin Houseman, MD, PhD Medical School: Visiting Faculty Columbia University College of Physicians and Surgeons Kerstin Kolodzie, MD New York, New York Visiting Assistant Professor Internship: Joined Faculty December 1, 2007 Internal Medicine Medical School: Oregon Health Sciences University University of Hamburg Portland, Oregon Hamburg, Germany

Timeline of Sentinel Cardiac Protection using Anesthetic Preconditioning Contributions Brian Cason Cloning of Capsaicin Receptor/Its Facilitation (Hickey R) Mark Schumacher 2001 Michael Gropper Linda Liu Renee Navarro Chairs, Chiefs, Director, ICU, Moffi tt, 2001 Director, Respiratory Therapy, 2001 Chief of Medical Staff, SFGH, 2001 and Directors

26 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Academic Department Chairs from UCSF

Bernard Brandstater American University of Beirut; Loma Linda University Michael Cahalan University of Utah David Cullen St. Elizabeth's Medical Center Kerstin Kolodzie, MD and Tufts University Bruce Cullen University of California, Irvine Internship: Gerald Edelist University of Toronto Technion-Israel Institute of Technology, John Eisele University of California, Davis The Ruth and Bruce Rappaport Faculty H. Barrie Fairley Stanford University of Medicine, Rambam Healthcare Greg Kronberg Wilford Hall Medical Center Campus Joerg Schaeuble, MD C. Philip Larson Stanford University Haifa, Israel Residency: Ronald D. Miller UCSF Anesthesia and Perioperative Care Anesthesiology Residencies: University of Hamburg, Anesthesiology Musa Muallem American University of Beruit University Medical Center Hospital of Waldshut Medical Center Hamburg-Eppendorf Waldshut, Germany Nancy Nussmeier Syracuse University Hamburg, Germany Anesthesiology Richard Palahniuk University of Manitoba; Previous Employment: District Hospital University of Minnesota Attending Anesthesiologist Tafers, Switzerland Michael Roizen University of Chicago; University of Hamburg, Internal Medicine Cleveland Clinic University Medical Center District Hospital Hamburg-Eppendorf Niederbipp, Switzerland Stephen Rupp Virginia Mason Medical Center Hamburg, Germany Anesthesiology Lawrence Saidman University of California, Cantonal Hospital of St. Gallen San Diego Joerg Schaeuble, MD St. Gallen, Switzerland David Schwartz University of Illinois Visiting Assistant Professor Fellowship: Donald Stanski Stanford University Joined Faculty December 1, 2007 Emergency Medicine Wendell Stevens University of Iowa; Medical Schools: Cantonal Hospital of St. Gallen University of Oregon Johann Wolfgang v. Goethe University St. Gallen, Switzerland Frankfurt, Germany Previous Employment: Robert Stoelting Indiana University Albert Ludwigs University of Freiburg ICU Attending Gale Thompson Virginia Mason Medical Center Freiburg, Germany Cantonal Hospital of St. Gallen John Wade University of Manitoba Internship: St. Gallen, Switzerland Jeanine Weiner-Kronish Internal Medicine & Surgery Attending Anesthesiologist Massachusetts General Hospital Hospital Villingen-Schwenningen University Hospital Basel Paul White University of Texas Villingen-Schwenningen, Germany Basel, Switzerland Southwestern Medical Center

Incentive-Productivity-Based Compensation System Improving Wound Healing Outcomes Implemented through Increased Oxygen Delivery John Feiner Harriet Hopf 2001 Patricia Roth William Shapiro Julin Tang William Young Director, Anesthesia Workroom, 2001 Chief, Mount Zion, 2001 Director, ICU, SFGH, 2001 James P. Livingston Endowed Chair in Anesthesia, 2001 TheUCSF Birth Anesthesia of a Department Residents

Class of 2011 Cristina Inglis-Arkell, MD Swetha Pakala, MD Medical School: Medical School: Daniel Abelson, MD University of California, San Diego, University of California, San Francisco, Medical School: School of Medicine School of Medicine University of California, San Francisco, School of Medicine April Jung, MD Jacob Pletcher, MD Medical School: Medical School: Michele Arnold, MD Drexel University College of Medicine Indiana University School of Medicine Medical School: University of California, San Francisco, James Kim, MD Anna Rabinowitz, MD School of Medicine Medical School: Medical School: Georgetown University School University of Pennsylvania School Daniel Chiem, MD of Medicine of Medicine Medical School: University of California, San Diego, School So Young Kim, MD John Turnbull, MD of Medicine Medical School: Medical School: Columbia University College University of California, San Francisco, Joshua Cohen, MD of Physicians and Surgeons School of Medicine Medical School: University of Illinois at Chicago College Tse-Sun Ku, MD Adrienne Valesano, MD of Medicine Medical School: Medical School: University of California, San Francisco, Georgetown University School of Medicine Robert Ellis, MD School of Medicine Medical School: Elaine Yang, MD Virginia Commonwealth University Sara LaFleur, MD Medical School: School of Medicine Medical School: New York University School of Medicine Tufts University School of Medicine Robert Feinglass, MD Afshin Zadfar, MD Medical School: Sarah Langley, MD Medical School: University of California, San Francisco, Medical School: State University of New York at Buffalo, School of Medicine Stanford University School of Medicine School of Medicine and Biological Sciences

Madina Gerasimov, MD Meagan Lansdale, MD Medical School: Medical School: New York University School of Medicine Stanford University School of Medicine

Amy Gin, MD Anuj Malhotra, MD Medical School: Medical School: New York Medical College Duke University School of Medicine

Roger Hong, MD Jemiel Nejim, MD Medical School: Medical School: Joan & Sanford I. Weill Medical College University of California, Los Angeles, of Cornell University David Geffen School of Medicine

Timeline of Sentinel Profound Isovolemic Hemodilution ARDSnet Trial Published Contributions Richard Weiskopf Michael Matthay (Feiner J, Lieberman J, Hopf H, Leung J, Kelly S) (Gropper M) 2002 Daniel Burkhardt Errol Lobo Martin London Chairs, Chiefs, Director, Acute Pain Service, 2002 Director, Vascular Anesthesia, 2002 Chair, UCSF Committee on Library, 2002 and Directors

28 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Stuart C. Cullen and William K. Hamilton Awardees

Stuart C. Cullen Award

Steven D. Jabaly, MD 1980 Neil Seeley, MD 1994 Glenn Plummer, MD 1981 Julie Nakao, MD 1994 Manuel Fernandez, MD 1982 Manuel Pardo, MD 1995 Lydia Cassorla, MD 1983 William Cammarano, MD 1996 George Lampe, MD 1983 Richard Green, MD 1997 Brian Cason, MD 1984 Thomas Buchheit, MD 1998 Edward Eisler, MD 1985 John F. Donovan, MD 1999 Jeanine Wiener-Kronish, MD 1986 Daniel M. Swangard, MD 1999 Ginger Fegert, MD 1987 Dhanesh K. Gupta, MD 2000 Scott Kelley, MD 1989 Brian W. Hite, MD 2000 Isobel Muhiudeen, MD, PhD 1989 James Mac Sams, MD 2001 Jaul Riazi, MD 1989 Donal P. Ryan, MD 2002 Amanda Sue Carlisle, MD 1990 Lundy J. Campbell, MD 2003 John R. Feiner, MD 1991 Grete H. Porteous, MD 2004 Barry D. Bergouist, MD 1992 Leonard Razzu Allmond, MD 2005 Erin P. Foley, MD 1992 Patrick M. Fujimoto, MD 2006 Peter S. Nosé, PhD, MD 1992 Jon Matthew Aldrich, MD 2007 Gretchen E. Hollingsworth, MD 1993 Scott Finkelstein, MD 2008 Oscar Fernandez, MD 1993

William K. Hamilton Award

Robert F. Hickey, MD 1973 Isobel A. Muhiudeen, MD, PhD 1991 Robert L. Willenkin, MD 1974 George A. Gregory, MD 1992 Robert H. Smith, MD 1975 Isobel A. Muhiudeen, MD, PhD 1992 Wendell C. Stevens, MD 1976 Anil De Silva, MD 1993 Marilyn Hulter, MD 1977 Anil De Silva, MD 1994 A. Roderick Forbes, MB 1978 Robert W. Allen, MD 1995 Dennis T. Mangano, PhD, MD 1979 James E. Caldwell, MB, ChB 1996 Neal H. Cohen, MD, MPH 1980 William Cammarano, MD 1997 H. Barrie Fairley, MB, BS 1980 William Cammarano, MD 1998 Cedric R. Bainton, MD 1981 Joan E. Howley, MD 1999 Sol M. Shnider, MD 1982 Kathryn Rouine-Rapp, MD 2000 Scott Robinson, MD 1983 Merlin D. Larson, MD 2001 H. Barrie Fairley, MB, BS 1984 Merlin D. Larson, MD 2002 Michael Cahalan, MD 1985 Daniel M. Swangard, MD 2003 Stephen Rupp, MD 1986 Mark Grabovac, MD 2004 Cedric R. Bainton, MD 1987 George A. Gregory, MD 2005 Donald Koblin, MD 1988 Mark D. Rollins, PhD, MD 2006 George A. Gregory, MD 1989 Lundy J. Campbell, MD 2007 Maurice Zwass, MD 1990 John Taylor, MD 2008

Anesthesia Simulator SFGH Manuel Pardo Center for Cerebrovascular Research (Collins A) William Young 2003 2004 Jeffrey Katz Manuel Pardo James Brandes A. Sue Carlise Perioperative Medical Director, 2003 Sol M. Shnider Endowed Chair for Director, Orthopedic/Regional Associate Dean, Anesthesia Education, 2003 Anesthesia, 2004 SFGH, 2004 Research Faculty Spotlight

Helen Kim, PhD Assistant Adjunct Professor Education and Training: MPH, Epidemiology, Emory University, Atlanta GA PhD, Epidemiology, University of Washington, Seattle, WA Postdoctoral Fellow, Genetic Epidemiology, University of Washington, Seattle, WA Research Interests: Genetic epidemiology of cardiovascular and neurological diseases, and in particular stroke Epidemiology and natural history of brain vascular malformations, including AVM and aneurysms Functional outcome after brain injury from intracranial hemorrhage or treatment Linkage and association studies of complex diseases and intermediate phenotypes Methods for detecting and adjusting for population stratifi cation, and evaluating interactions Helen Kim, PhD Susan Lynch, PhD Assistant Adjunct Professor Education and Training: BS, Industrial Microbiology (minors in Chemistry and Biostatistics), University College, Dublin, Ireland PhD, Department of Microbiology, University College, Dublin, Ireland Postgraduate Education, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA Research Interests: Polymicrobial pathogenesis of respiratory diseases including, cystic fi brosis, asthma, ventilator-associated pneumonia, chronic rhinosinusitis and chronic obstructive pulmonary disease. Biofi lm formation and virulence gene expression of the respiratory pathogen Pseudomonas aeruginosa from both Cystic Fibrosis (CF) and ICU patients Understanding of the response of Pseudomonas aeruginosa in a clinical setting, Susan Lynch, PhD improve diagnosis and provide effi cacious strain-specifi c combinatorial therapeutic options to improve patient outcome. Uses culture-independent tools recently developed in the fi eld of microbial ecology together with high-throughput sequencing and statistical analysis to examine the contribution of microbial community structure and function to pathogen behavior, host response and clinical outcome. Development of a rapid, multi-species, culture-independent tool to improve diagnosis of respiratory infections and profi le antimicrobial resistance in parallel. Examines therapeutic strategies in vitro and in vivo that target various virulence systems of Pseudomonas aeruginosa and uses sequential clinical isolates to study how micro- and macro-evolution affects the physiology of this opportunistic pathogen.

Timeline of Sentinel Monoclonal Antibody for Contributions Treatment of Botulinum Neurotoxins NIH Training Grant James Marks Jeanine Wiener-Kronish 2004 Andrew Gray Jeremy Lieberman Renee Navarro Chairs, Chiefs, Director, Regional Anesthesia, SFGH, 2004 Director, Spine Anesthesia, Associate Dean, Academic Affairs, 2004 2004 and Directors

30 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Ludmila Pawlikowska, PhD Hua Su, MD

Ludmila Pawlikowska, PhD Assistant Adjunct Professor Education and Training: Ph.D. Biomedical Sciences, UCSF Postdoctoral training: Liver Center, Cardiovascular Research Institute and Institute for Human Genetics, UCSF Research Interests: Genetic studies of complex disease including brain arteriovenous malformation and subarachnoid hemorrhage Genetic studies of human longevity and aging-related phenotypes Admixture mapping of metabolic syndrome traits and infl ammatory markers in admixed populations Molecular genetics of inherited cholestasis

Hua Su, MD Assistant Adjunct Professor Education and Training: MD, Medicine, 1982, Nanjing Medical University, Nanjing, China MS, Histology and Embryology, 1985, Xian Medical University, Xian, China Postdoctoral Fellow, Reproductive Physiology, 1986, Beijing Medical University, Beijing, China Postdoctoral Fellow, Medical Genetics, 1992, University of California, San Francisco, CA Research Interests: Viral vector mediated targeted gene expression Gene and cell based therapies for ischemic heart disease Gene and cell based therapies for cerebral vascular diseases Development of rodent arteriovenous malformation model

Developer of Endotracheal Sonography for Nerve Block Localization Cardiac Output Monitor Andrew Gray Arthur Wallace (Collins A) 2005 Gerard Ozanne James Caldwell Jens Krombach Kathryn Rouine-Rapp Acting Chief, VAH, 2004 Director, Clinical Anesthesia, 2005 Director, Clinical Anesthesia, SFGH, 2005 Director, Preoperative (Prepare) Clinic, 2005

ANESTHESIA NEWS 31 Peer Reviewed Publications 2007–2008

Abou-Arab MH, Heier T, Caldwell JE. Dose of alfentanil needed to obtain Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D. optimal intubation conditions during rapid-sequence induction of Monitoring serial change in the lumen and outer wall of vertebrobasilar anaesthesia with thiopentone and rocuronium. Br J Anaesth. aneurysms. AJNR Am J Neuroradiol. Feb;29(2):259-64, 2008. May;98(5):604-10, 2007. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, Acute coagulopathy of trauma: hypoperfusion induces systemic Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL. anticoagulation and hyperfi brinolysis. J Trauma. May;64(5):1211-7, 2008. Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner malformation treatment. Neurosurgery. Oct;61(4):731-9; discussion 740, JM. Ammonia has anesthetic properties. Anesth Analg. Jun;104(6):1430-3, 2007. 2007.

Afonin ON, Miller RD. Sugammadex: An analysis and update. ASEAN J. Brosnan RJ, Eger EI 2nd, Laster MJ, Sonner JM. Anesthetic properties of Anaesthesiology 8:35-40, 2007. carbon dioxide in the rat. Anesth Analg. Jul;105(1):103-6, 2007.

Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson Carles M, Dellamonica J, Roux J, Lena D, Levraut J, Pittet JF, Boileau P, R, Maze M, Franks NP. Determinants of the anesthetic sensitivity of two-pore Raucoules-Aime M. Sevofl urane but not propofol increases interstitial domain acid-sensitive potassium channels: molecular cloning of an glycolysis metabolites availability during tourniquet-induced ischaemia- anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol reperfusion. Br J Anaesth. Jan;100(1):29-35, 2008. Chem. Jul 20;282(29):20977-90, 2007. Cascio M, Xing Y, Gong D, Popovich J, Eger EI 2nd, Sen S, Peltz G, Sonner Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ, JM. Mouse chromosome 7 harbors a quantitative trait locus for isofl urane Jankowska K, Eger EI 2nd. Hexafl uorobenzene acts in the spinal cord, minimum alveolar concentration. Anesth Analg. Aug;105(2):381-5, 2007. whereas o-difl uorobenzene acts in both brain and spinal cord, to produce immobility. Anesth Analg. Apr;104(4):822-8, 2007. Champion HR, Fingerhut A, Escobar MA, Weiskopf RB. The role of data and safety monitoring in acute trauma resuscitation research. J Am Coll Surg. Antognini JF, Atherley RJ, Dutton RC, Laster MJ, Eger EI 2nd, Carstens E. The Jan;204(1):73-83, 2007. excitatory and inhibitory effects of nitrous oxide on spinal neuronal responses to noxious stimulation. Anesth Analg. Apr;104(4):829-35, 2007. Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler PE, Drew KL. Arctic ground squirrel (Spermophilus parryii) hippocampal Apfel CC, Kranke P, Piper S, Rüsch D, Kerger H, Steinfath M, Stöcklein K, neurons tolerate prolonged oxygen-glucose deprivation and maintain Spahn DR, Möllhoff T, Danner K, Biedler A, Hohenhaus M, Zwissler B, baseline ERK1/2 and JNK activation despite drastic ATP loss. J Cereb Blood Danzeisen O, Gerber H, Kretz FJ. [Nausea and vomiting in the postoperative Flow Metab. Jul;28(7):1307-19, 2008. phase. Expert- and evidence-based recommendations for prophylaxis and therapy] Anaesthesist. Nov;56(11):1170-80, 2007. Coburn M, Kunitz O, Apfel CC, Hein M, Fries M, Rossaint R. Incidence of postoperative nausea and emetic episodes after xenon anaesthesia Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA. Septate junctions compared with propofol-based anaesthesia. Br J Anaesth. are required for ommatidial integrity and blood-eye barrier function in Jun;100(6):787-91 2008. Drosophila. Dev Biol. May 15;317(2):585-99, 2008. Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU. coagulopathy after traumatic brain injury: the role of hypoperfusion and the Remote renal injury following partial hepatic ischemia/reperfusion injury in protein C pathway. J Trauma. Dec;63(6):1254-61, 2007. rats. J Gastrointest Surg. Mar;12(3):490-5, 2008. Cohen NH. Advance directives: know what you want, get what you need. Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI 2nd, Pearce RA. Mayo Clin Proc. Dec;82(12):1460-2, 2007. Determination of the EC50 amnesic concentration of etomidate and its diffusion profi le in brain tissue: implications for in vitro studies. Du R, Keyoung HM, Dowd CF, Young WL, Lawton MT. The effects of Anesthesiology. Jan;106(1):114-23, 2007. diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations. Neurosurgery. Berman MF, Young WL. Commentary on: Brain arteriovenous malformation Apr;60(4):638-46, 2007. and its implication in forensic pathology. J Forensic Sci. Sep;52(5):1225, 2007. Dubowitz G, Peacock AJ. Pulmonary artery pressure in healthy subjects at 4250 m measured by Doppler echocardiography. Wilderness Environ Med. Boussel L, Wintermark M, Martin A, Dispensa B, VanTijen R, Leach J, Rayz V, Winter;18(4):305-11 2007.

Timeline of Sentinel Manual of Anesthesia Practice (1st PDA Textbook in Anesthesia) Contributions Department of Anesthesia Manuel Pardo, James Sonner First in NIH Funding (Primarily authored by UCSF residents) 2005 David Lee Atsuko Baba Philip Bickler Chairs, Chiefs, Director, Pain Management Center, 2005 Director, Pediatric Prepare Clinic, Director, Orthopedic/Regional 2006 Anesthesia, 2006 and Directors

32 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Edwards KL, Hutter CM, Yin Wan J, Kim H, Monks SA. Genome-wide Linkage severe preservation reperfusion injury. J Surg Res. Jun 1;140(1):77-83, Scan for the Metabolic Syndrome: The GENNID Study. Obesity (Silver Spring). 2007. Jul;16(7):1596-1601, 2008. Gabriel RA, Yang GY. Gene therapy in cerebrovascular diseases. Curr Gene Eger EI 2nd, Lemal D, Laster MJ, Liao M, Jankowska K, Raghavanpillai A, Ther. Dec;7(6):421-33, 2007. Popov AV, Gan Y, Lou Y. Anesthetic properties of some fl uorinated oxolanes and oxetanes. Anesth Analg. May;104(5):1090-7, 2007. Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS, Hooper VD, Kovac AL, Kranke P, Myles P, Philip BK, Samsa G, Sessler DI, Temo J, Tramèr MR, Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. The rat vanilloid Vander Kolk C, Watcha M; Society for Ambulatory Anesthesia. Society for receptor splice variant VR.5’sv blocks TRPV1 activation. Neuroreport. Jul Ambulatory Anesthesia guidelines for the management of postoperative 2;18(10):969-73, 2007. nausea and vomiting. Anesth Analg. Dec;105(6):1615-28, 2007.

El Solh AA, Akinnusi ME, Wiener-Kronish JP, Lynch SV, Pineda LA, Szarpa K. Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE, Persistent infection with Pseudomonas aeruginosa in ventilator-associated Prough DS, Baus D, Bepperling F, Warltier DC. Volume replacement therapy pneumonia. Am J Respir Crit Care Med. Sep 1;178(5):513-9, 2008. during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch. Anesthesiology. Jun;106(6):1120-7, 2007. Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y. Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res. Jul Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, 11;1219:1-7, 2008. Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin- Fan Y, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young dependent mechanisms. Circ Res. Apr 11;102(7):804-12, 2008. WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab. Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Jan;28(1):90-8, 2008. Christiaans SC, Bir ND, Pittet JF. ngiopoietin-2, marker and mediator of endothelial activation with prognostic signifi cance early after trauma? Ann Fan Y, Yang GY. Therapeutic angiogenesis for brain ischemia: a brief review. Surg. Feb;247(2):320-6, 2008. J Neuroimmune Pharmacol. Sep;2(3):284-9, 2007. Gelb AW, Craen RA, Rao GS, Reddy KR, Megyesi J, Mohanty B, Dash HH, Feiner JR, Severinghaus JW, Bickler PE. Dark skin decreases the accuracy Choi KC, Chan MT. Does hyperventilation improve operating condition during of pulse oximeters at low oxygen saturation: the effects of oximeter probe supratentorial craniotomy? A multicenter randomized crossover trial. Anesth type and gender. Anesth Analg. Dec;105(6 Suppl):S18-23, 2007. Analg. Feb;106(2):585-94, 2008.

Fiebig EW, Wu AH, Krombach J, Tang J, Nguyen KA, Toy P. Transfusion- Gelb K, Gelb AW. Sex and gender in the perioperative period: wake up to related acute lung injury and transfusion-associated circulatory overload: reality. Anesth Analg. Jul;107(1):1-3, 2008. mutually exclusive or coexisting entities? Transfusion. Jan;47(1):171-2, 2007. Gropper MA, Wiener-Kronish J. The epithelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care. Feb;14(1):11-5, 2008. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary perfused human lungs. Am J Physiol Lung Cell Mol Physiol. Jul;293(1):L52-9, delivery of bone marrow-derived mesenchymal stem cells improves survival 2007. and attenuates endotoxin-induced acute lung injury in mice. J Immunol Aug 1;179(3):1855-63, 2007. Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil Feb;63(2):147-53, 2008. depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. Nov;27(11):1853-60, 2007. Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL. Feasibility of minocycline and doxycycline use Hasegawa K, Hu C, Nakamura T, Marks JD, Russell SJ, Peng KW. Affi nity as potential vasculostatic therapy for brain vascular malformations: pilot thresholds for membrane fusion triggering by viral glycoproteins. J Virol. study of adverse events and tolerance. Cerebrovasc Dis. 25(1-2):157-63, Dec;81(23):13149-57, 2007. 2008. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D, Niemann CU. Transient hyperglycemia affects the extent of ischemia- Niemann CU. Glutamine donor pretreatment in rat kidney transplants with

UCSF PainCARE - Center for Advanced Critical Care Medicine and Trauma CME Course Research and Education Michael Gropper Pamela Palmer 2006 Lundy Campbell James Marks Ronald D. Miller Manuel Pardo Director, Thoracic Anesthesia, 2006 Chief, SFGH, 2006 President of Medical Staff, Vice Chair for Education, 2006 UCSF Medical Center, 2006

ANESTHESIA NEWS 33 reperfusion-induced renal injury in rats. Anesthesiology. Mar;108(3):402-14, Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol 2008. AS, Lawton MT, Higashida RT, Young WL; UCSF BAVM Study Project. Racial/ Ethnic differences in longitudinal risk of intracranial hemorrhage in brain Hopf HW, Rollins MD. Wounds: an overview of the role of oxygen. Antioxid arteriovenous malformation patients. Stroke. Sep;38(9):2430-7, 2007. Redox Signal. Aug;9(8):1183-92, 2007. Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, oxide synthase polymorphism (-786T->C) and increased risk of angiographic Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Apr;39(4):1103-8, 2008. Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Komatsu R, Turan AM, Orhan-Sungur M, McGuire J, Radke OC, Apfel CC. Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Remifentanil for general anaesthesia: a systematic review. Anaesthesia. Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y, Dec;62(12):1266-80, 2007. Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Kreuer S, Bruhn J, Walter E, Larsen R, Apfel CC, Grundmann U, Biedler A, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A, Wilhelm W. Comparative pharmacodynamic modeling using bispectral and Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon- narcotrend-index with and without a pharmacodynamic plateau during Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, sevofl urane anesthesia. Anesth Analg. Apr;106(4):1171-81, 2008. Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S, Krombach J, Gray AT. Sonography for saphenous nerve block near the Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de adductor canal. Reg Anesth Pain Med. Jul-Aug;32(4):369-70, 2007. Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe’er I, Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC, Larson MD. Mechanism of opioid-induced pupillary effects. Clin Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson Neurophysiol. Jun;119(6):1358-64, 2008. GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin Laster MJ, Zhang Y, Eger EI 2nd, Shnayderman D, Sonner JM. Alterations in N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M, spinal, but not cerebral, cerebrospinal fl uid Na+ concentrations affect the Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T, isofl urane minimum alveolar concentration in rats. Anesth Analg. Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I, Sep;105(3):661-5, 2007. Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu Lawton MT, Arnold CM, Kim YJ, Bogarin EA, Stewart CL, Wulfstat AA, Derugin R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton N, Deen D, Young WL. Radiation arteriopathy in the transgenic arteriovenous EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E, fi stula model. Neurosurgery. May;62(5):1129-38, 2008. Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ, Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J, Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL. Matrix metalloproteinase-9 Burton J, Carter NP, Clee CM, Griffi ths M, Jones MC, McLay K, Plumb RW, inhibition attenuates vascular endothelial growth factor-induced intracerebral Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg hemorrhage. Stroke Sep;38(9):2563-8, 2007. JC, L’Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z, Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson MA. Acute lung injury edema fl uid decreases net fl uid transport across R, Stewart J. A second generation human haplotype map of over 3.1 million human alveolar epithelial type II cells. J Biol Chem. Aug SNPs. Nature. Oct 18;449(7164):851-61, 2007. 17;282(33):24109-19, 2007.

Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA, Lee JW, Matthay MA. Protein permeability in lung injury: now in real time Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ. Duloxetine for again? J Appl Physiol. Feb;102(2):508-9, 2007. the management of diabetic peripheral neuropathic pain: evidence-based fi ndings from post hoc analysis of three multicenter, randomized, double- Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. blind, placebo-controlled, parallel-group studies. Clin Ther. 29 Apolipoprotein E e4 allele increases the risk of early postoperative delirium Suppl:2536-46, 2007. in older patients undergoing noncardiac surgery. Anesthesiology. Sep;107(3):406-11, 2007. Kessler J, Gray AT. Sonography of scalene muscle anomalies for brachial plexus block. Reg Anesth Pain Med. Mar-Apr;32(2):172-3, 2007. Lieberman JA, Lyon R, Feiner J, Hu SS, Berven SH. The effi cacy of motor evoked potentials in fi xed sagittal imbalance deformity correction surgery.

Timeline of Sentinel Recovery of Airway Refl exes Contributions following Inhaled Anesthetics Rachel McKay Miller’s Anesthesia, 6th Edition 2006 Laura Siedman John Taylor C. Spencer Yost Chairs, Chiefs, Associate Medical Director, Ambulatory Director, PACU, 2006 Director, ICU, Mount Zion, 2006 Surgery Center, 2006 and Directors

34 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Spine. Jun 1;33(13):E414-24, 2008. Niemann CU, Serkova NJ. Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opin Drug Metab Toxicol. Liu B, Conrad F, Roth A, Drummond DC, Simko JP, Marks JD. Recombinant Aug;3(4):527-44, 2007. full-length human IgG1s targeting hormone-refractory prostate cancer. J Mol Med. Oct;85(10):1113-23, 2007. Olivares M, Terwiesch C, Cassorla L. Structural Estimation of the Newsvendor Model: An Application to Reserving Operating Room Time Liu L, Gropper MA. Tracheostomy protocol compliance: herding cats? Crit Management Science 54(1):41-55, 2008. Care Med. Jun;36(6):1959-60, 2008. Orhan-Sungur M, Kranke P, Sessler D, Apfel CC. Does supplemental oxygen Lynch SV, Yang K, Brodie EL, MacDougal C, Andersen GL, Wiener-Kronish JP. reduce postoperative nausea and vomiting? A meta-analysis of randomized Culture-Independent Bacterial Population Analysis - Clinical Implications for controlled trials. Anesth Analg. Jun;106(6):1733-8, 2008. Respiratory and Other Infections Curr Respir Med Rev. Feb;4(1):35-39, 2008. Ozgediz D, Kijjambu S, Galukande M, Dubowitz G, Mabweijano J, Mijumbi C, Lynch SV, Wiener-Kronish JP. Novel strategies to combat bacterial virulence. Cherian M, Kaggwa S, Luboga S. Africa’s neglected surgical workforce crisis. Curr Opin Crit Care. Oct;14(5):593-599, 2008. Lancet. 23;371(9613):627-8, 2008.

Lynch SV, Dixon L, Benoit MR, Brodie EL, Keyhan M, Hu P, Ackerley DF, Ozgediz D, Galukande M, Mabweijano J, Kijjambu S, Mijumbi C, Dubowitz G, Andersen GL, Matin A. Role of the rapA gene in controlling antibiotic Kaggwa S, Luboga S. The neglect of the global surgical workforce: resistance of Escherichia coli biofi lms. Antimicrob Agents Chemother. experience and evidence from Uganda. World J Surg. Jun;32(6):1208-15, Oct;51(10):3650-8, 2007. 2008.

Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofi ore G, Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU. Niemann C, Walia A, Vater Y, Tran ZV, Kam I. A multicenter evaluation of Increased severity of renal ischemia-reperfusion injury with venous clamping safety of early extubation in liver transplant recipients. Liver Transpl. compared to arterial clamping in a rat model. Surgery Feb;143(2):243-51, Nov;13(11):1557-63, 2007. 2008.

Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE. Phelps P, Cakmakkaya OS, Apfel CC, Radke OC. A simple clinical maneuver Interleukin-6 and atrial fi brillation in patients with coronary artery disease: to reduce laparoscopy-induced shoulder pain: a randomized controlled trial. data from the Heart and Soul Study. Am Heart J. Feb;155(2):303-9, 2008. Obstet Gynecol. May;111(5):1155-60, 2008.

McKay RE, Rapan R. Infl uence of body mass index on recover of protective Pittet JF, Song Y, Wiener-Kronish JP. Treating lung infections with airway refl exes after anesthesia with desfl urane or sevofl urane. Eur J anticoagulation: mechanisms matter. Crit Care Med. Jan;36(1):356-7, 2008. Anaesthesiol. 25(Suppl 44):2AP2-7, 2008. Rayz VL, Lawton MT, Martin AJ, Young WL, Saloner D. Numerical simulation McKay RE, Rozner MA. Preventing pacemaker problems with nerve of pre- and postsurgical fl ow in a giant basilar aneurysm. J Biomech Eng. stimulators. Anaesthesia. May;63(5):554-6, 2008. Apr;130(2):021004, 2008.

Miller RD. Editorial, 4th Asian Esmeron Expert meeting (AEEM). ASEAN J. Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy Anaesthesiology 8:1-2, 2007. E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris Miller RD. Sugammadex May Replace Best Clinical Practice: A T, Zmuda JM, Ziv E; Health, Aging and Body Composition (Health ABC) Study. Misconception Anesth Analg. Nov;105:(5):1507, 2007. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. Apr;80(4):716-26, 2007. Miller RD. Sugammadex: an opportunity to change the practice of anesthesiology? Anesth Analg. Mar;104(3):477-8, 2007. Rosales CM, Young T, Laster MJ, Eger EI 2nd, Garg U. Sevofl urane concentrations in blood, brain, and lung after sevofl urane-induced death. J Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM. Anesthetic-like Forensic Sci. Nov;52(6):1408-10, 2007. modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased Roth A, Drummond DC, Conrad F, Hayes ME, Kirpotin DB, Benz CC, Marks neurotransmitters. Anesth Analg. Aug;105(2):386-92, 2007. JD, Liu B. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther. Mok JM, Lyon R, Lieberman JA, Cloyd JM, Burch S. Monitoring of nerve root Oct;6(10):2737-46, 2007. injury using transcranial motor-evoked potentials in a pig model. Spine. Jun 15;33(14):E465-73, 2008.

Implements National Anesthesia, ICU, NIH Training Grant Analytic Electronic Information System for VAH Jean-François Pittet Gerard Ozanne (Young W) 2007 Roland Bainton Lee-lynn Chen John Kulli Member, Program in Biologic Acting Chief, Mount Zion, 2007 Perioperative Medical Director, Sciences, 2007 2007

ANESTHESIA NEWS 35 Serkova NJ Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell Jankowska I, Pawłowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson MS. Early detection of graft failure using the blood metabolic profi le of a liver RJ. Severe bile salt export pump defi ciency: 82 different ABCB11 mutations recipient. Transplantation. Feb 27;83(4):517-21, 2007. in 109 families. Gastroenterology. Apr;134(4):1203-14, 2008.

Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno- Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, associated viral vector-mediated hypoxia-regulated VEGF gene transfer Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther. regulates lung vascular permeability and pulmonary endothelial barrier Jan;15(1):30-9, 2008. function. Am J Respir Cell Mol Biol. Mar;36(3):377-86, 2007.

Shiga T, Apfel CC, Wajima Z, Ohe Y. Infl uence of intraoperative conversion Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, from off-pump to on-pump coronary artery bypass grafting on costs and Grossman W, Kan YW. AAV serotype 1 mediates more effi cient gene transfer quality of life: a cost-effectiveness analysis. J Cardiothorac Vasc Anesth. to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. Dec;21(6):793-9, 2007. Jan;10(1):33-41, 2008.

Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the gene expression in ischemic hearts. Methods Mol Biol. 366:331-42, 2007. organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. Feb;83(2):273-80, 2008. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury Singh V, Smith WS, Lawton MT, Halbach VV, Young WL. Risk factors for in mice and rats. Am J Respir Cell Mol Biol. Aug;37(2):186-92, 2007. hemorrhagic presentation in patients with dural arteriovenous fi stulae. Neurosurgery. Mar;62(3):628-35, 2008. Talke PO, Maze M. Expecting the unexpected. Anesth Analg. Jun;106(6):1605-6, 2008. Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith LA, Marks JD, Xie G, Brettin TS. Analysis of the Neurotoxin Complex Genes Tang Y, Lou J, Alpaugh RK, Robinson MK, Marks JD, Weiner LM. Regulation in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent Clusters Are Located within Plasmids. PLoS ONE. Dec 5;2(12):e1271, 2007. affi nity for target antigen. J Immunol. Sep 1;179(5):2815-23, 2007.

Song Y, Pittet JF, Huang X, He H, Lynch SV, Violette SM, Weinreb PH, Horan Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan GS, Carmago A, Sawa Y, Bernstein XL, Wiener-Kronish JP. Role of integrin K, Kwok PY, Whooley MA, Conklin BR. Gene-trapped mouse embryonic stem alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa. cell-derived cardiac myocytes and human genetics implicate AKAP10 in Infect Immun. Jun;76(6):2325-32, 2008. heart rhythm regulation. Proc Natl Acad Sci U S A. May 15;104(20):8461-6, 2007. Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI 2nd, Homanics GE. Effect of isofl urane and other Tseng ZH, Aouizerat BE, Pawlikowska L, Vittinghoff E, Lin F, Whiteman D, potent inhaled anesthetics on minimum alveolar concentration, learning, and Poon A, Herrington D, Howard TD, Varosy PD, Hulley SB, Malloy M, Kane J, the righting refl ex in mice engineered to express alpha1 gamma- Kwok PY, Olgin JE. Common beta-adrenergic receptor polymorphisms are aminobutyric acid type A receptors unresponsive to isofl urane. not associated with risk of sudden cardiac death in patients with coronary Anesthesiology. Jan;106(1):107-13, 2007. artery disease. Heart Rhythm. Jun;5(6):814-21, 2008.

Sonner JM. A hypothesis on the origin and evolution of the response to Tsui JY, Collins AB, White DW, Lai J, Tabas JA. Videos in clinical medicine. inhaled anesthetics. Anesth Analg. Sep;107(3):849-54, 2008. Placement of a femoral venous catheter. N Engl J Med. Jun 26;358(26):e30, 2008. Sonner JM. Ethnicity can affect anesthetic requirement. Anesthesiology. Jul;107(1):4-5, 2007. Turatti F, Figini M, Balladore E, Alberti P, Casalini P, Marks JD, Canevari S, Mezzanzanica D. Redirected activity of human antitumor chimeric immune Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C. Organization receptors is governed by antigen and receptor expression levels and affi nity and function of the blood-brain barrier in Drosophila. J Neurosci. Jan of interaction. J Immunother. Oct;30(7):684-93, 2007. 16;28(3):587-97, 2008. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Pharmacol Ther. Mar;83(3):416-21 2008. Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH,

Timeline of Sentinel Pain Management Center Award Basics of Anesthesia, 5th Edition, Clinical Center of Excellence from the Editor, Ronald D. Miller Contributions American Pain Society Most Chapters Written by Pamela Palmer Members of the Department 2007 Susan Lee Renee Navarro Chairs, Chiefs, Interim Director, Director, Academic Diversity, 2007 Pain Management, VAH, 2007 and Directors

36 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, manipulation of immune function for asthma prevention: inferences from Guccione JM. Magnetic resonance imaging-based fi nite element stress clinical trials. Proc Am Thorac Soc. Jul;4(3):277-82, 2007. analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. May;135(5):1094-102, 1102.e1-2, 2008. Yost CS, Gropper MA. The curse of the drinking class. Crit Care Med. Jun;36(6):1958-9, 2008. Wang Y, Jiang L, Guo X, Gelb AW, Yue Y; Chinese Society of Anesthesiology. The Chinese Society of Anesthesiology: 2006 annual meeting. Anesth Analg. Young WL, Kwok PY, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk Oct;105(4):1132-5, 2007. DA. Arteriovenous malformation. J Neurosurg. Apr;106(4):731-2 2007.

Wang Y, Gelb AW, Yue Y. The Chinese Society of Anesthesiology: 2007 Annual Young WL. Anesthesia for endovascular neurosurgery and interventional Meeting report. Anesth Analg. Jun;106(6):1853-4, 2008. neuroradiology. Anesthesiol Clin. Sep;25(3):391-412, vii, 2007.

Weigle DS, Buben A, Burke CC, Carroll ND, Cook BM, Davis BS, Dubowitz G, Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. Exogenous ethyl pyruvate Fisher RE, Freeman TC, Gibbons SM, Hansen HA, Heys KA, Hopkins B, Jordan versus pyruvate during metabolic recovery after oxidative stress in neonatal BL, McElwain KL, Powell FL, Reinhart KE, Robbins CD, Summers CC, Walker rat cerebrocortical slices. Anesthesiology Oct;107(4):630-40, 2007. JD, Weber SS, Weinheimer CJ. Adaptation to altitude as a vehicle for experiential learning of physiology by university undergraduates. Adv Physiol Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Educ. Sep;31(3):270-8, 2007. Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical Weiskopf RB. Recombinant-activated coagulation factor VIIa (NovoSeven): left ventricular aneurysm increases systolic circumferential shortening in current development. Vox Sang. May;92(4):281-8, 2007. sheep. J Thorac Cardiovasc Surg. Oct;134(4):1017-24, 2007.

Weiskopf RB. The ethics of blood management. Vox Sang. Jul;93(1):91, Zhang Y, Laster MJ, Eger EI 2nd, Sharma M, Sonner JM. Blockade of 2007. acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats. Anesth Analg. Apr;104(4):850-2, 2007. Wong-Beringer A, Wiener-Kronish J, Lynch S, Flanagan J. Comparison of type III secretion system virulence among fl uoroquinolone-susceptible and Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD. -resistant clinical isolates of Pseudomonas aeruginosa. Clin Microbiol Infect. Impact of single-chain Fv antibody fragment affi nity on nanoparticle Apr;14(4):330-6, 2008. targeting of epidermal growth factor receptor-expressing tumor cells. J Mol Biol. Aug 24;371(4):934-47, 2007. Xue Q, Schumacher MA. New insights into the role of the capsaicin receptor (TRPV1) in infl ammatory pain. CellScience 3: 1-6, 2007. Zhu W, Tian Y, Zhou LF, Wang Y, Song D, Mao Y, Yang GY. Development of a novel endothelial cell-seeded endovascular stent for intracranial aneurysm Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1 utilizes therapy. J Biomed Mater Res A. Jun 1;85(3):715-21, 2008. a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. Apr;101(1):212-22, 2007. Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y. Insulin growth factor-1 gene transfer enhances neurovascular remodeling Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. and improves long-term stroke outcome in mice. Stroke. Apr;39(4):1254-61, Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and 2008. acetone. Anesth Analg. Sep;105(3):673-9, 2007. Zhu W, Khachi S, Hao Q, Shen F, Young WL, Yang GY, Chen Y. Upregulation of Yang L, Sonner JM. Anesthetic-like modulation of receptor function by EMMPRIN after permanent focal cerebral ischemia. Neurochem Int. surfactants: a test of the interfacial theory of anesthesia. Anesth Analg. May;52(6):1086-91, 2008. Sep;107(3):868-74, 2008. Zhuo H, Yang K, Lynch SV, Dotson RH, Glidden DV, Singh G, Webb WR, Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on Elicker BM, Garcia O, Brown R, Sawa Y, Misset B, Wiener-Kronish JP. wild-type and mutant gamma-aminobutyric acid type A and glycine Increased mortality of ventilated patients with endotracheal Pseudomonas receptors. Anesth Analg. Mar;106(3):838-45, 2008. aeruginosa without clinical signs of infection. Crit Care Med. Sep;36(9):2495-503, 2008. ■ Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. Aug;105(2):393-6, 2007.

Yoo J, Tcheurekdjian H, Lynch SV, Cabana M, Boushey HA. Microbial

Identifi cation of Protein C Activation as a Critical Mechanism for Development of Early Coagulopathy in Trauma Patients Mechanisms of Inhaled Anesthetic Actions Jean-François Pittet James Sonner (Chesebro B, Cohen M) 2008 Manuel Pardo Martin Stechert Jens Krombach Director, UCSF Kanbar Simulation Center, 2007 Director, Respiratory Therapy, VAH, 2007 Perioperative Director, SFGH, 2008

ANESTHESIA NEWS 37 Active Research Grants

Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award Apfel, Christian Principal Investigator Merck & Co, Inc. Individual Rsch Grant Development of a Predictive Model for Post-Discharge Nausea and 06/01/07 - 05/31/08 $727,538 Vomiting (PDNV) Apfel, Christian Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double Dummy, Dose-Ranging, Active-and 08/01/07 - 07/31/08 $116,499 Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the Prevention of Postoperative Nausea and Vomiting (PONV) Apfel, Christian Principal Investigator Anesiva, Inc Clinical Trial A multicenter, randomized, double-blind, placebo-controlled, parallel-group 04/30/08-06/30/09 $132,288 study to evaluate effi cacy, safety and tolerability of a single intraoperative localized instillation of 4975 in patients undergoing primary unilateral total hip arthroplasty Apfel, Christian Principal Investigator Anesiva, Inc IndivRschGrant/Contract A Phase 3, Multicenter, Randomized, Placebo-Controlled, Parallel-Group, 04/30/08 - 06/30/09 $209,282 Double-Blind Study to Evaluate the Effi cacy, Tolerability, Safety, and Pharmacokinetics of 4975 in Patients Undergoing Primary Unilateral Total Knee Arthroplasty Bainton, Roland Principal Investigator NIGMS/NIH Individual Rsch Grant Physiology aand Regulation of Drug Transport Across the Blood Brain 08/01/07 - 05/31/12 $1,456,540 Barrier Bainton, Roland Principal Investigator EON Research Corporation Subcontract Blood Brain Barrier Modulators 04/01/08 - 09/30/09 $167,400 Behrends, Matthias Principal Investigator REAC/Springer H Mem FDN Individual Rsch Grant Reduction of Hepatic Ischemia/Reperfusion Injury by Short-Term 03/01/07 - 02/28/09 $25,000 Pretreatment with Simvastatin Bickler, Philip Principal Investigator NIGMS/NIH Individual Rsch Grant Intracellular Signaling in Anesthetic and Hypoxic Preconditioning of 04/01/07 - 02/28/11 $1,241,507 Neurons Bickler, Philip Principal Investigator University of Alaska Subcontract Advancing UAF SNRP 05/01/06 - 04/30/11 $368,781 Bickler, Philip Principal Investigator Various Industry Sponsors Other Clinical Contract Accuracy of Pulse Oximeters with Profound Hypoxia 09/01/86 - Present Varies per contract Chen, Yongmei Principal Investigator NINDS/NIH Individual Rsch Grant Del-1 Induces Therapeutic Cerebral Angiogenesis 05/01/06 - 10/30/08 $365,576 Chen, Yongmei Principal Investigator American Heart Association Individual Rsch Grant Netrin-1 in Neurovascular Regeneration 07/01/08 - 06/30/10 $140,000 (AHA) Dubowitz, Gerald Principal Investigator Mt. Zion Health Fund Individual Rsch Grant Safety and Acceptability of IV method (UCSF Invention SF2006-14) in 04/01/08 - 03/31/09 $40,500 Operative and Critical Care Anesthesia Practice Eger, Edmond Principal Investigator NIGMS/NIH Specialized Center Grant Sites & Mechanisms of Inhaled Anesthetic Actions 08/01/04 - 07/31/09 $7,321,207 Eilers, Helge Principal Investigator Hellman Family Awards Individual Rsch Grant Anesthetic Effects on Peripheral Nociceptors 01/01/08 - 12/31/08 $40,000 Gelb, Adrian Principal Investigator Hospira, Inc. Individual Rsch Grant Depth of Anesthesia with the Sedline Facilitates Motor Evoked Potential 12/19/07 - 12/19/09 $80,000 (MEP) Monitoring During Corrective Spinal Surgery Gelb, Adrian Principal Investigator Johnson and Johnson Clinical Trial A Randomize, Double-Blind, Active- and Placebo-Controlled, Parallel 12/08/06 - 06/30/08 $235,400 Group, Multicenter Study to Evaluate the Effi cacy and Safety of Multiple Doses of CG5503 Immediate-Release Formulation in the Treatment of Acute Pain from Tota Gropper, Michael Project Leader #2 NHLBI/NIH Specialized Center Grant Transfusion and Lung Injury (SCCOR Grant) 09/30/05 - 08/31/10 $825,757 Hashimoto, Tomoki Principal Investigator NINDS/NIH Individual Rsch Grant Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling 02/01/07 - 01/31/11 $1,282,367 and Infl ammation Hashimoto, Tomoki Principal Investigator American Heart Association Individual Rsch Grant/ Pathophysiology of Intracranial Aneurysms - Roles of Macrophages and 07/01/07 - 06/30/09 $140,000 (AHA) Cooperative Agreement Vascular Remodeling Houseman, Benjamin Principal Investigator Helen Diller Family Individual Rsch Grant Using microfl uidic technology to study dynamic kinase inhibitor therapy 07/01/08 - 06/30/09 $30,000 Comprehensive Cancer Center Howard, Marybeth Principal Investigator Academic Senate Individual Rsch Grant Regulation of STAT1 Signaling Pathway by the Stress of Protein Response 07/15/06 - 07/14/08 $28,000 Kim, Helen Principal Investigator REAC/Huntington G & S Individual Rsch Grant Whole Genome Amplifi cation of Archived, Paraffi n-Embedded AVM Tissue 03/01/07 - 02/28/09 $25,459 MEM FD Kim, Helen Principal Investigator American Heart Association Individual Rsch Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous 07/01/07 - 06/30/08 $65,000 (AHA) Malformations Kim, Helen Principal Investigator NINDS/NIH Instruction Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous 07/01/08 - 06/30/13 $782,716 Malformations Lee, Chanhung Principal Investigator American Heart Association Individual Rsch Grant Infl uence of Matrix Metalloproteinase on Brain Arteriovenous Malformation 01/01/07 - 12/31/10 $260,000 (AHA) Hemorrhage Lee, Jae Woo Principal Investigator Foundation for Anesthesia Instruction Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury in Primary 01/01/08 - 12/31/08 $115,000 Education & Research (FAER) Cultures of Human Alveolar Epithelial Type II Cells and in the Ex Vivo Perfused Human Lung Lee, Jae Woo Principal Investigator NHLBI/NIH Individual Rsch Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury 08/04/08 – 07/31/13 $608,850 Leung, Jacqueline Principal Investigator Anesthesia Patient Safety Individual Rsch Grant Pathophysiology of Postoperative Delirium 01/01/08 - 06/30/09 $149,800 Foundation (APSF) Litt, Lawrence Principal Investigator NIGMS/NIH Individual Rsch Grant 2D NMR of Energy Rescue from PARP in Brain Slice Hypoxia 06/01/04 - 05/31/09 $1,332,605 Liu, Bin Principal Investigator NCI/NIH Individual Rsch Grant Mapping a Clinically Signifi cant Internalizing Tumor Epitope Space 03/07/06 - 1/31/11 $1,334,984 Liu, Bin Principal Investigator DOD/Army Ovarian Cancer Individual Rsch Grant Defi ning and Targeting of an Ovarian Cancer Spefi cic Internalizing Epitope 01/01/04 - 10/31/08 $664,066 Research Program Space Liu, Bin Principal Investigator Mesothelioma Applied Individual Rsch Grant Identifi cation of Mesothelioma Specifi c Cell Surface Antigens 01/01/07 - 12/31/08 $100,000 Research Foundation (MARF) Liu, Bin Principal Investigator American Association for Individual Rsch Grant Internalizing Human Antibodies Targeting Pancreatic Tumor Cells in Situ 07/01/08 - 06/30/10 $100,000 Cancer Research/AACR London, Martin Principal Investigator Anesthesia Patient Safety Individual Rsch Grant Perioperative Pharmacologic Prophylaxis for Cardiovascular Events in the 01/01/06 - 12/31/08 $75,000 Foundation (APSF) Dept of Veterans Affairs: A Pharmacoepidemiologic Pilot Project Lynch, Susan Principal Investigator American Lung Association Individual Rsch Grant Analysis of Bacterial Community Dynamics in Adult Patients with 07/01/07 - 06/30/09 $80,000 (ALA) Exacerbations of Chronic Objective Pulmonary Disease: The Effect of Microbial Community Composition on Pathogen Abundance and Patient Health Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc Individual Rsch Grant Collection of Clinical Respiratory Samples and Pseudomonas Aeuruginosa 01/07/08 - 10/16/08 $54,647 for Validation of a Novel Culture Independent Diagnostic Lynch, Susan Principal Investigator NIAID/NIH Individual Rsch Grant Resequencing Microarray for Rapid Detection & Antimicrobial Resistance 08/01/07 - 07/31/12 $3,562,568 Profi ling Lynch, Susan Principal Investigator NHLBI/NIH Individual Rsch Grant Gene Expression and Pathogenicity of P. Aeruginosa 12/11/03 - 11/30/08 $1,465,957 Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effect of Humanized anti PcrV Antibody on Total Bacterial Community 03/01/08 - 02/28/09 $152,415 Composition of Adult Patients with Cystic Fibrosis

38 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Project #2: Effect of Humanized anti PcrV Antibody on Total Bacterial 07/01/08 - 06/30/09 $133,514 Community Composition of Adult Patients with Cystic Fibrosis Marks, James Principal Investigator DTRA/DOD Defense Threat IndivRschGrant/Contract Antibody Based Therapy for Botulism 01/18/07 - 01/17/10 $1,187,549 Reduction Agency Marks, James Principal Investigator PHS Centers for Disease Individual Rsch Grant Preparation of High Affi nity Monoclonal Antibodies for Use with the 07/01/06 - 05/31/09 $1,075,166 Control (CDC) Endopep MS Assay to Detect and Differentiate Botulinum Neurotoxins Marks, James Project Leader #5 NCI/NIH Specialized Center Grant Phage Display Antibodies (SPORE-BREAST) 03/01/03 - 06/30/08 $1,060,697 Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy 07/15/03 - 12/31/08 $5,040,609 Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy, Setotypes C, D, 08/15/07 - 07/31/12 $3,782,514 F, and G Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Murine-Specifi c Targeting Ligands for Transcytosis 06/01/07 - 05/31/08 $108,731 Through the Blood-Brain Barrier Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Novel Human-Specifi c Targeting Ligands for Transcytosis 06/01/07 - 05/31/09 $472,763 Through the Blood-Brain Barrier Marks, James Principal Investigator XOMA Subcontract Development of a Final Drug Product for a Mixture of Monoclonal 09/06/06 - 07/27/09 $956,891 Antibodies for Type A Botulinum Neurotoxins Marks, James Principal Investigator Genomic Systems IndivRschGrant/Contract Human Antibodies to PDGFR for Cancer Therapy 06/28/07 - 06/27/12 $102,359 Marks, James Principal Investigator DOD/IDEA Individual Rsch Grant Engineering Anti-EGFR Antibodies for Treatment of Brease Cancers With 09/01/07 - 09/30/10 $463,144 Poor Prognosis Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Adaptive Immunity from High Affi nity Anti-HER2/neu Monoclonal Antibodies 09/01/06 - 06/30/11 $382,832 Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Defi ning the Role of Affi nity in Antibody-Based Tumor Targeting and 02/05/07 - 01/31/12 $812,588 Therapy Marks, James Principal Investigator Functional Genetics Subcontract Determining the Impact of Epitope and Affi nity of TSG101 Antibodies on 06/23/06 - 09/01/08 $263,922 Anti-Viral Activity Marks, James Principal Investigator The Lustgarten Foundation for Individual Rsch Grant Lustgarten Foundation for Pancreatic Cancer Research Biomarker Initiative 04/01/08 - 09/30/09 $306,171 Pancreatic Research McKay, Rachel Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double-Dummy, Dose-Ranging, Active-and 09/01/07 - 08/31/08 $113,399 Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the Prevention of Postoperative Nausea and Vomiting (PONV) Niemann, Claus Principal Investigator International Anesthesia Individual Rsch Grant Ischemia Reperfusion Injury During Total Knee Athroplasty: The Impact of 01/01/07 - 12/31/08 $80,000 Research Society (IARS) Metabolic Syndrome Niemann, Claus Principal Investigator HRSA Individual Rsch Grant Intensive Insulin Therapy in Deceased Donors to Improve Renal Allograft 09/01/08 - 08/31/11 $821,251 Function and Transplanted Allograft Outcomes Palmer, Pamela Principal Investigator The Mayday Fund Instruction Grant Pain CARE Center 06/01/05 - 05/31/08 $179,400 Pittet, Jean Principal Investigator NIGMS/NIH Individual Rsch Grant Stress Preconditioning and Alveolar Epithelial Injury 12/01/06 - 11/30/10 $1,045,089 Pittet, Jean Project Leader #4 NIGMS/NIH Specialized Center Grant TGF-Beta and Lung Epithelial Injury (SCCOR GRANT) 09/30/03 - 06/30/08 $1,769,262 Pittet, Jean Program Director NIGMS/NIH Training Grant Comprehensive Anesthesia Research Training 07/01/07 - 06/30/12 $933,595 Pittet, Jean Principal Investigator InCode BioPharmaceutics, Inc. IndivRschGrant/Contract Compliment Inhibition and Protein C Pathway 5/13/08-5/12/09 $29,355 Rollins, Mark Principal Investigator Foundation for Anesthesia Instruction Grant A Comparison of Tissue Oxygen Levels in Multiple Organs During 01/01/06 - 12/31/08 $255,000 Education & Research (FAER) Isovolemic Hemodilution with Right and Left-Shifted Hemoglobin-Based Blood Substitutes Rollins, Mark Principal Investigator Anesthesia Patient Safety Individual Rsch Grant Supplemental Oxygen: A Reduction in Pulse Oximetry Sensitivity or an 01/01/08 - 12/31/08 $150,000 Foundation (APSF) Increased Margin of Safery Roux, Jeremie Principal Investigator American Lung Association Fellowhsip Grant Role of Stress Protein Response on IL-1 Beta-Mediated Inhibition on ENaC 07/01/06 - 06/30/08 $65,000 (ALA) Expression and Function in Lung Epithelial Cells Sall, Jeffrey Principal Investigator Foundation for Anesthesia Instruction Grant Volatile Anesthetic Toxicity in Hippocampal Derived Progenitor Cells 01/01/07 - 12/31/08 $255,000 Education & Research (FAER) Schumacher, Mark Principal Investigator National Headache Foundation Individual Rsch Grant Regulation of Capsaicin Receptor (TRPV1) Expression in Meningeal 04/01/08 - 03/31/09 $16,000 Sensory Neurons Under Infl ammatory Conditions Song, Yuanlin Principal Investigator Academic Senate Individual Rsch Grant Role of PAI-1 in Acute Lung Injury Induced by P. Aeruginosa 03/01/08 - 02/28/09 $23,876 Song, Yuanlin Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effi cacy of MAB166 as an Adjuvant Therapy to Standard of Care 01/08/08 - 07/08/08 $86,884 Antimicrobial Therapy in a Mouse Model of Acute Lung Injury Sonner, James Principal Investigator NIGMS/NIH Individual Rsch Grant Genes Underlying the Response to Inhaled Anesthetics 07/15/04 - 06/30/09 $2,061,572 Stratmann, Greg Principal Investigator Anesthesia Patient Safety Individual Rsch Grant Effectiveness of Three Clinically Applicable Strategies to Improve Safety of 01/01/07 - 12/31/08 $150,000 Foundation (APSF) Neonatal Anesthesia Su, Hua Princpal Investigator American Heart Association Individual Rsch Grant Bone Marrow Mesenchymal Stem Cell Mediated Hypoxia-Responsive 07/01/05 - 06/30/09 $260,000 (AHA) Angiogenic Gene and Cell Therapy for Ischemic Heart Tang, Julin Principal Investigator Pfi zer US Pharmaceuticals Clinical Trial Linezolic in the Treatment of Subjects with Nosocomial Pneumonia Proven 03/24/06 - 12/31/08 $207,194 to be Due to Methicillin-Resistant Staphylococcus Aureus Tang, Julin Principal Investigator Hospira, Inc. Individual Rsch Grant A Prospective, Randomized, Controlled Study on the Use of 09/24/07 - 09/23/10 $154,966 Dexmedetomidine to Facilitate Extubation in Surgical Intensive-Care Unit Patients Who Failed Previous Weaning Attempts Following Prolonged Mechanical Ventilation Tang, Julin Principal Investigator Ortho-McNeil, Inc Clinical Trial A Phase 2, Open-Label, Non-Comparative Study of Doripenem in the 05/21/07 - 8/31/08 $121,705 Treatment of Nosocomical and Ventillator-Associated Pneumonia in Hospitals Where Pseudomonas Aeruginosa May Be A Prevalent Pathogen Yang, Guo-Yuan Principal Investigator The Sturge-Weber Foundation Individual Rsch Grant Development of Cerebrovascular Dysplasia Model for SWS Study 08/01/07 - 07/31/08 $60,000 Yost, Charles Principal Investigator NIGMS/NIH Individual Rsch Grant Background Potassium Channels as Anesthetic Targets 03/03/06 - 02/28/09 $888,576 Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 07/01/08 - 06/30/13 $1,974,062 Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Hemodynamics of Cerebral Arteriovenous Malformations 06/01/05 - 04/30/09 $1,302,842 Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 09/01/05 - 06/30/09 $1,401,376 Young, William Program Director NINDS/NIH Program Project Grant Integrative Study of Brain Vascular Malformations 09/30/03 - 06/30/09 $6,487,825 Young, William Principal Investigator Columbia University Clinical Trial Sub Award A Randomized Trial of Unruptured Brain Arteriovenous Malformations 01/13/06 - 07/31/11 $288,600 Young, William Principal Investigator The Aneurysm and AVM Individual Rsch Grant PET and Magnetic Resonance Modeling to Assess the Risk of 11/01/07 - 10/31/09 $50,000 Foundation/TAAF Aneurysm Rupture Young, William and Project Leaders California Institute for Specialized Center Grant Human Stem Cell Derived Oligodendrocytes for Treatment of 08/01/07 - 07/31/11 $200,000 Yang, Guo-Yuan Regenerative Medicine/CIRM Stroke and MS

ANESTHESIA NEWS 39 UCSF Center For Cerebrovascular Course Co-Chairs: Department Chairman Editor-in-Chief Research CCR/PPG Rochelle Dicker, MD Ronald D. Miller, MD Seminars Assistant Professor in Residence Department of Surgery Executive Editor: Presented by the Center for San Francisco General Hospital Cerebrovascular Research Marge O’Halloran Mark Eisner, MD, MPH Department of Anesthesia and Associate Professor Perioperative Care Editor: Department of Anesthesia, Department University of California, San Francisco Morgen Ahearn of Medicine Division of Occupational and San Francisco General Hospital Environmental Medicine and Division of Designer: For a list of upcoming seminars: Pulmonary and Critical Care Medicine UCSF Documents, Media & Mail http://avm.ucsf.edu/ UCSF Medical Center For a list of past seminars: Julin Tang, MD, MS Principal Writer: http://avm.ucsf.edu/research/recent_seminars.html Clinical Professor Andrew Schwartz Department of Anesthesia Critical Care Medicine and Director, Critical Care Medicine Photographers: Trauma 2009 San Francisco General Hospital Michael Lee Christine Jegan Program and registration information: May 28-May 30, 2009 Marco Sanchez www.cme.ucsf.edu InterContinental Mark Hopkins Hotel Richard Schlobohm San Francisco, California Brant Ward Various UCSF Anesthesia Staff Course Director: Michael A. Gropper, MD, PhD Professor and Vice Chair Department of Anesthesia and Perioperative Care Director, Critical Care Medicine UCSF Medical Center

Anesthesia News

Department of Anesthesia and Department of Anesthesia and Non-Profi t Org. Perioperative Care Grand Rounds Perioperative Care U.S. Postage PAID University of California First and Third Wednesdays 310 San Francisco of every month University of California 6:30 a.m.-8:00 a.m. San Francisco Room C 701, Box 0648 521 Parnassus Ave. San Francisco, CA 94143-0648 San Francisco, California www.anesthesia.ucsf.edu