Manual2010.Pdf

2010

Anti-Ageing Conference London September 9-11, 2010

1 1 Welcome Dear Colleague,

I am both pleased and proud to welcome you to the 7th Annual Anti- Ageing Conference London (AACL) 2010. We are now in our seventh year of providing a unique, high quality experience for the leading physicians, researchers ,scientists and medical students who will be attending. We are excited about our distinguished lecturers and the interesting topics which they will be presenting this year.

I am also happy to report that we have made significant progress toward another of the goals we set for these conferences - that was to increase awareness and understanding of anti-ageing medicine in the UK, and to bring the message of preventive healthcare to greater numbers of medical practitioners. It gives me great satisfaction to see that we are accomplishing what we set out to do. This year I would like to extend a very warm welcome to our Medical Students. HBHealth set up a medical sponsorship scheme 4 years ago, this allows medical students to attend the AACL conference as our guests giving them a unique opportunity to ‘rub shoulders’ with our illustrious speakers from around the world

I am confident that you as well will enjoy this opportunity for networking with other members of the international medical and scientific community, and to meet leading scientists in 21st century medicine. This conference blends a high quality academic programme typical of a large scientific congress, with the intimacy, exclusivity and access to speakers typical of a small symposium. In addition to the lectures, the conference hosts an exhibition, with the newest products and services available to prevent ageing, disease and improve longevity. I would also like to extend a warm welcome to our 2 Keynote Speakers Professor Bernd Klein-Gunk President of the German Society of Anti-Aging Medicine (GSAAM) His presentation on Saturday Anti-Aging the first 4000 years will be truly fascinating On Friday our Keynote Speaker will be Dr Eric Braverman. Joining him this year will be speakers from around the world, Dr Ghaly, Prof Merchant, Mr Patton, USA,. From Europe- Italy Dr Pierpaoli, Dr Di Nicola, Prof Scapagnini, Spain Dr Amar, ,Portugal, Dr Evangelista, Germany, Prof Ionescu, Dr Lammers, Prof Weber, ,and from the UK Prof Reinstein,Dr Martinez,Dr Maizetova, Dr Sister,Mr Stead,Ms Campion and Dr Perring.

Anti-Ageing Conference London (AACL) is proud to support and be affiliated with the British Society of Anti-Ageing Medicine (BSAAM),the British Longevity Society(BLS) the European Society of Anti- Ageing Medicine (ESAAM),World Society of Anti-Aging Medicine (WSAAM) the World Academy of Anti- Ageing Medicine (WAAAM), and the American Academy of Anti-Ageing Medicine (A4M).CPD services have accredited this conference. Our thanks also go to Sun Chlorella who have provided the conference and Gala Dinner bags and TA Sciences who have sponsored the Gala Cocktail Party We will continue our efforts to advance the cause of Anti-Ageing Medicine both here in the UK and Internationally.

These independent, non-commercial lectures are made possible every year due to the philanthropic support and organisation of conference sponsor HB Health.

I look forward to sharing this experience with you.

Heather Bird-Tchenquiz Chairperson AACL Founder and President, HB Health Director; World Anti-Ageing Academy of Medicine (WAAAM) Board Member, European Society of Anti-Ageing Medicine (ESAAM) Director of British Society of Anti-Ageing Medicine (BSAAM)

23 3 Table of Contents Welcome 2 Sponsors 4 Academic Associates 5 Programme 8 Accreditation 13 Peer Review 14 Speakers 19 Exhibitors 50 Supporters 59 Acknowledgements 60 Contacts 61

23 3 Sponsors

HB Health of Harley Street, 12 Beauchamp Place, SW3 1NQ Tel: +44 (0)20 7838 0765 - Fax: +44 (0)20 491 0410 HB Health of Knightsbridge, 12 Beauchamp Place, SW3 1NQ Tel: +44 (0)20 7838 0765 - Fax +44(0)20 7838 0766 www.hbhealth.com

London’s Premier Anti-Ageing Clinic, HB Health, is the proud sponsor and organiser of the 1st, 2nd, 3rd, 4th and 5th 6th Anti Ageing Conference London (AACL).

HB Health is a specialist anti-ageing group that provides expert treatments to its clients that incorporate 21st Century medical advances from around the world. Although no one is claiming to overwrite genetics, there are significant benefits to be gained from lifestyle changes. The philosophy behind the clinic is pro-active and not re-active. Through education, patient responsibility and well supported nutritional and lifestyle changes, they aim to prevent damage and even reverse it.

Heather Bird-Tchenguiz, Founder and President of HB Health, is a leading visionary of anti- ageing and preventative medicine. She strives to promote anti-ageing medicine as a medical speciality by serving on the board of the nonprofit World Academy of Anti-Ageing Medicine (WAAAM), Board member European Society of Anti-Ageing Medicine (ESAAM), Director of British Society of Anti-Ageing Medicine (BSAAM).

Heather feels passionate about making sure that life enhancing medical breakthroughs of Anti-Ageing Medicine are made available to as many people as possible. As part of that commitment, she was co-sponsor and co-organiser of several Anti-Ageing events globally and is delighted to again sponsor the Anti-Ageing Conference in London (AACL) 2008.

At HB Health we believe wholeheartedly that prevention is better than cure, and that you should be young from the inside out. Many diseases of modern society are silent and degenerative; such as heart disease, high blood pressure, diabetes, strokes and Alzheimer’s .HB Health believe that an early detection plan, together with an individualized programme targeting lifestyle, nutrition and fitness, will prevent and possibly reverse the effects of preventative disease, optimise well-being and delay ageing.

For clients to achieve their personal wellness and performance goals it requires care and planning. Our philosophy therefore is that clients should possess ‘A Prescription for Life’, supported by our “7 Pillars Plan”, being the seven core components which we believe will provide our clients with the optimum results.

Our teams include internationally respected doctors, working alongside a wide range of superior practitioners, who through an integrated approach deliver great results every time. Our research includes continued development of nutritional and cosmetic products designed to maximise client and patient results. We take into account every patient’s personal and family history, lifestyle and work commitments to tailor for them ‘A Prescription for Life’.

45 5 Academic Associates

The World Anti Aging Academy of Medicine (WAAAM) is dedicated to the protection and preservation of the health of the public, and the advancement of education in connection with anti- ageing medicine. By promoting understanding and research into anti-aging medicine, it is hoped that the speciality will become better established in the UK and abroad. The wider use of anti- aging therapies should lead to general relief from the effects of degenerative disease, as well as a reduction in the economic burden of treating and caring for sufferers.

The WAAAM was incorporated on 15 August 2001 in England/Wales. It is not a commercial profit-making organization and is registered with the UK Charity Commission. The Academy has been established with the support and active involvement of the board of the American Academy of Anti-Aging Medicine (‘A4M’). For further details please visit www.waaam.org

European Society of Anti-Ageing Medicine (ESAAM) was incorporated in March 2003 in Paris. ESAAM is a non-profit organisation based in Vienna Austria.

ESAAM acts as ‘an umbrella’ to the National Anti-Ageing Societies in Europe (EU and Turkey) who have become members of ESAAM.

Aims • Continuous education of doctors so enabling them to adopt the highest standards according to the latest research results in Anti-Ageing. • Certification through the National Societies as a member of ESAAM. • Development of high quality standards of education for the education of doctors in Anti- Ageing Medicine in Europe. • Developing guidelines for Anti-Ageing Medicine for Europe. • Intellectual support for scientific projects leading to a new insight in the clinical relevant management of patients seeking advice in Anti-Ageing practices.

Objectives • Standardization of the European Anti-Ageing Medicine Education on a high quality level (ECARE) - subunit of ESAAM. • Collecting experiences of the Research medicine and introducing them into the standardization Anti-Ageing Medicine, so initiating high quality medicine. • Support for research in the area of early prevention of age-related diseases, collecting and collating data, supplied by National Societies.

For further information please contact the Secr. General Michael Klentze anti-aging@ klentze.org [email protected] and visit www.esaam.com

45 5 Academic Associates

British Society for Anti-Ageing medicine (BSAAM) was incorporated in London as the UK representative, to achieve the aims and objectives of ESAAM. BSAAM is a non-profit organisation based in the UK. BSAAM is not supported by industry or any other profit- making organisation.

Aims • Maintaining and developing contact with ESAAM and any other National Anti-Ageing Societies members within Europe (EU and Turkey). • Developing contacts with non European Societies and working closely with WAAAM. • Supporting and Realising the aims and Objectives of ESAAM.

Objectives • Support for research in the area of early prevention of age-related diseases. • Develop ideas and initiatives for the continual education of doctors to attain the highest standards according to the latest results in Anti-Ageing Medicine. • Establish intellectual support for scientific projects leading to a new insight in the clinical relevant management of patients seeking advice in Anti-Ageing practices.

For further information please contact BSAAM at www.bsaam.com or email us on: [email protected]

The BHMA was formed in 1983 by a group of medical doctors and students as an organisation for professionals and members of the public who wanted to adopt a more holistic approach in their own life and work. Twenty years on, the Association is just as determined to play a major role in ensuring that a whole person approach is central to the effective practice of healthcare. To achieve our core purpose, the Association will reach out to decision makers and those working in healthcare to demonstrate the added value that holistic practice brings to patients and practitioners alike. Through a significant nationwide membership of influential and like-minded individuals there is no doubt that the BHMA can help to shape the future of healthcare in the UK. We have, therefore, developed a programme of activity that is designed to enable the dissemination of information, and to create opportunities for people with an interest in whole person care to share their experiences and ideas.

Why is the BHMA relevant? It is a time of great opportunity for holistic thinking and practice. Despite the huge increase in the NHS budget and advances in the medical management of diseases such as cancer and heart failure, patients and health workers alike are dissatisfied with the quality of

67 7 Academic Associates

healthcare. There is a widespread search for better integration of healthcare effort, and holistic understandings of health and dignity. At the same time, advances in science reveal that the body-mind behaves more like a self-healing hologram than a stack of diagnostic categories. Increasingly researchers challenge the relevance of test tube science when considering the dynamic interplay of factors required for good health: an aliveness of spirit and quality therapeutic relationships.

The British Society of Integrated Medicine was formed in 2002 by a group of Doctors involved in combining the best of complimentary and nutritional medicine with conventional medicine. The looming issue of revalidation for Doctors, and also the regulation of this are of medicine by the Healthcare Commission has been and continues to be an important driving force for us gathering together as a Society. We held our inaugural conference at the Royal College of Physicians in May 2003. Since then we have had two conferences a year at the Royal College.

We also have members who are complimentary therapists, vets and dentists. Our conference topics and interests of our members covers a wide field. eW would like to attract as many new members as possible.

After negotiating for over two years with the Charities Commission, we are nearly at the stage where we are registered as a charity.

For further details go to www.bsim.org.uk or contact Julian Kenyon, email addresses: [email protected], telephone number 01962 718000 (Twyford, Winchester) or 0207 580 8886 (London) or Patrick Kingsley, e-mail address [email protected] or Dr Rodney Adeniye-Jones [email protected]

67 7 7th Annual Anti Ageing Conference London 2010 (AACL2010) Programme for Friday, September 10th, 2010 AACL 2010 08:00 Registration Opens 09:00 - 09:15 Welcome Programme Heather Bird-Tchenguiz MBA Chairperson, AACL. Founder and President, HB Health. Director, World Academy of Anti-Aging Medicine WAAAM Director, British Society of Anti-Ageing Medicine BSAAM Board member for ESAAM 09:15 - 09:45 Lecture Dr Zulya Maizetova She received her medical degree and her Masters in Dermatology at the Medical University of Saint Petersburg. Dr. Maizetova has an integrated method of its prevention and reversal of skin aging through specific treatments to improve the body's own ability to regenerate itself explored. This method is safe, non-toxic and non-invasive. Resveratrol - A real benefit or just a conundrum

09:45 - 10:15 Lecture Dr Miguel Martinez Dr Martinez started the exciting discovery of medicine at the University of Barcelona (Spain) and continued with further training in Obstetrics & Gynaecology together with General Practice in the UK. He obtained the Diploma in Aesthetics & Anti-Aging Medicine from the University of Barcelona that led to the European Anti-Aging Medicine Speciality in Brussels (Belgium) and Paris (France). A Protein Diet: An efficient and scientific weapon for weight loss. 10:15 - 10:45 Lecture Dr Hansjörg Lammers DMD PhD Specialist in Holistic Environmental Dentistry Nationwide Center for Systemic Detoxification in Chronic Diseases. Metal-Free Dentistry to Avoid Arteriosclerosis and Cancer

10:45 - 11:15 Morning Tea/Coffee 11:15 - 11:45 Lecture Dr Michael Perring MA MB B.Chir FCP(SA) DPM UKCP Registered Psychotherapist Certified member of the American Academy of Anti-Aging Medicine, is registered as a practising psychotherapist and is accredited by the British Association of Sexual and Marital Therapists of which he is a founder member. Maintaining sexual function in later life 11:45 - 12:15 Lecture Mr Richard Stead CEO/ Molecular Design Director, KiB Ltd The relationship between an inefficient immune system and ageing

12:15 - 12:45 Lecture Mr Simon Agius Consultant to the Natural Products Wellness Sector Advancement in the treatment of non-melanoma skin cancers

12:45 - 13:15 Q&A Speaker Panel Dr Zulya Maizetova Dr Michael Perring Dr Miguel Martinez Mr Richard Stead Dr Hansjörg Lammers Mr Simon Agius 13:15 End Morning Session

Please note this programme may be subject to change

89 9 7th Annual Anti Ageing Conference London 2010 (AACL2010) Programme for Friday, September 10th, 2010 08:00 Registration Opens 09:00 - 09:15 Welcome Heather Bird-Tchenguiz MBA Chairperson, AACL. Founder and President, HB Health. Director, World Academy of Anti-Aging Medicine WAAAM Director, British Society of Anti-Ageing Medicine BSAAM Board member for ESAAM 09:15 - 09:45 Lecture Dr Zulya Maizetova She received her medical degree and her Masters in Dermatology at the Medical University of Saint Petersburg. Dr. Maizetova has an integrated method of its prevention and reversal of skin aging through specific treatments to improve the body's own ability to regenerate itself explored. This method is safe, non-toxic and non-invasive. Resveratrol - A real benefit or just a conundrum

12:15 - 12:45 Lecture Mr Simon Agius Consultant to the Natural Products Wellness Sector Advancement in the treatment of non-melanoma skin cancers

12:45 - 13:15 Q&A Speaker Panel Dr Zulya Maizetova Dr Michael Perring Dr Miguel Martinez Mr Richard Stead Dr Hansjörg Lammers Mr Simon Agius 13:15 End Morning Session

Please note this programme may be subject to change

89 9 7th Annual Anti Ageing Conference London 2010 (AACL2010) Programme for Friday, September 10th, 2010 14:30 Begin Afternoon Session 14:30 - 15:00 Lecture Mr Noel Thomas Patton Noel Thomas Patton is Founder and Chairman of T.A. SCIENCES. In 2002 The Geron Corporation exclusively licensed to Noel TA-65, a single small molecule with cellular rejuvenation properties that activates the enzyme telomerase. In 2007, Noel through T.A. Sciences, based in New York, commercialized TA-65, the world’s first telomerase activator. Telomere Biology: The Emerging Paradigm Shift 15:00 - 15:30 Lecture Dr Walter Pierpaoli MD PhD President, INTERBION Foundation for Basic Biomedical Research Aging-Reversing Properties of Thyrotropin Releasing Hormone (TRH)

15:30 - 16:00 Lecture Dr Eric R Braverman MD Dr. Eric Braverman is the Director of The Place for Achieving Total Health (PATH Medical), with locations in New York, NY, Penndel, PA (metro-Philadelphia), and a national network of affiliated medical professionals. Hormones and the Brain

16:00 - 16:30 Afternoon Tea/Coffee 16:30 - 17:00 Lecture Dr Eric R Braverman MD Dr. Eric Braverman is the Director of The Place for Achieving Total Health (PATH Medical), with locations in New York, NY, Penndel, PA (metro-Philadelphia), and a national network of affiliated medical professionals. Leptin Imbalances and Aging - The Secret of Obesity Science

17:00 - 17:30 Lecture Dr Daniel Sister MD Graduated from the Paris Medical School. Member of: General Medical Council (UK), Conseil de l'Ordre des Medecins (Fr), British Association of Cosmetic Doctors., New York Academy of Sciences., Royal Society of Medicine (Fellow) Platelet Rich Plasma Therapies - Self Stimulated Serum - S3

17:30 - 18:00 Workshop Ms Galina Imrie MA Ed Founder of the International Register of Integrative Colon Therapists and Trainers and Principal of the Chi Centre for Practical Detoxification and Aqua-Clinic Colleges. Colon Hydrotherapy and the Chemistry of Wellbein

18:00 - 18:30 Speaker Panel & Discussion Dr Walter Pierpaoli Mr Noel Thomas Patton Dr Eric R Braverman Ms Galina Imrie Dr Daniel Sister 18:30 Conference Closes

Please note this programme may be subject to change

1011 11 7th Annual Anti Ageing Conference London 2010 (AACL2010) Programme for Saturday, September 11th, 2010 08:00 Registration Opens 09:00 - 09:15 Welcome Heather Bird-Tchenguiz MBA Chairperson, AACL. Founder and President, HB Health. Director, World Academy of Anti-Aging Medicine WAAAM Director, British Society of Anti-Ageing Medicine BSAAM Board member for ESAAM 09:15 - 09:45 Lecture Dr Roger Elie Amar Dr. Roger Elie Amar is a French plastic surgeon graduated from University of Paris France. He has been assistant professor in Anatomy and assistant professor in Plastic and Reconstructive Surgery in Marseilles, France. Cell therapy for facial rejuvenation (F.A.M.I.) Fat autograft muscle injection 09:45 - 10:15 Lecture Dr Valerio Di Nicola MD PhD He was Head of the General Surgery Department at San Marco Hospital in Latina, Italy. Currently he is a Consultant of the General Surgery Department at the Israelite Hospital of Rome. Self-Repair in Degenerative Joint Disease

10:15 - 10:45 Lecture Prof Dr med Bernd Kleine-Gunk President of the German Society of Anti-Aging Medicine (GSAAM) Anti-Aging - The first 4000 Years (part 1)

10:45 - 11:15 Morning Tea/Coffee 11:15 - 11:45 Lecture Prof Dr med Bernd Kleine-Gunk President of the German Society of Anti-Aging Medicine (GSAAM) Anti-Aging - The first 4000 Years (part 2)

11:45 - 12:15 Lecture Mrs Constance Campion Although well known as a seasoned City analyst in the advanced rejuvenation healthcare science sectors, Constance Campion brought Wall Street logic to medical enterprise and the medical profession in 1989, when she outlined and illustrated evidence that medical aesthetics would become one of the most sought after elective areas of medicine, outstripping demand for aesthetic surgery. Economics of an antiageing practice 12:15 - 12:45 Lecture Dr Fouad I Ghaly MD FCCP A graduate from the University of Alexandria Medical School, Egypt, then completing his residency at Johns Hopkins Hospital in Baltimore, Maryland. His own heart attack changed his expertise from cardiovascular anesthesiology to the practice of longevity medicine. President, Founder: Longevity & Rejuvenation Clinics of California Enhanced External Counterpulsation (EECP): A Non-Invasive Out Patient Procedure to Revascularize the Heart Muscle without Open Heart Surgery 12:45 - 13:15 Speaker Panel Dr Roger Elie Amar Prof Dr med Bernd Kleine-Gunk Dr Valerio Di Nicola Mrs Constance Campion Dr Fouad I Ghaly 13:15 End Morning Session

Please note this programme may be subject to change

1011 11 7th Annual Anti Ageing Conference London 2010 (AACL2010) Programme for Saturday, September 11th, 2010 14:30 Begin Afternoon Session 14:30 - 15:00 Lecture Prof Dan Z Reinstein MD MA(Cantab) FRCSC DABO FRCOphth Professor Reinstein is a GMC registered specialist in ophthalmology in the United Kingdom, equally certified by the American Board of Ophthalmology and the Royal College of Physicians and Surgeons of Canada. Clinical practice at the London Vision Clinic. Setting the clock back on ageing eyes: treating presbyopia by laser eye surgery

15:00 - 15:30 Lecture Prof John G Ionescu PhD He is Scientific Director and founder of the Spezialklinik Neukirchen for the treatment of allergic, skin and environmental diseases according to the principles of nutrition and environmental medicine. After graduating in Biochemistry and Immunology at the University of Bucharest he specialized in Medical Biochemistry at the University of Saarbruecken in Germany and he directed a research program in a dermatological clinic in Aschaffenburg. His main research areas include atopic diseases, psoriasis, arthritis and the MCS-syndrome. How to assess an anti-inflammatory diet 15:30 - 16:00 Speaker Forum Moderator - Professor Syed Haq 16:00 - 16:30 Afternoon Tea/Coffee 16:30 - 17:00 Lecture Dr Carlos Evangelista MD Coordenator of the geriatric orthopaedic unit of Orthopedic Hospital of Santana. Anti-Aging Articular Process

17:00 - 17:30 Lecture Prof Dr Bernard Weber A medical doctor and CEO of Laboratoires Réunis, a private medical laboratory based in Luxembourg, Europe. Laboratoires Réunis is a national leader in the field of predictive genetics and molecular diagnosis of infectious diseases and is ISO 15189 accredited since 2006. In the last five years Dr Weber and his team have developed and validated a unique panel of phenotypic and genotypic markers which constitute a very important tool for the integrative approach of multifactorial and environment linked diseases. Genetic Analysis of Different SNPs as Potential Biomarkers in Colorectal Cancer 17:30 - 18:00 Workshop Prof Randall E Merchant PhD Professor of Anatomy & Neurobiology Virginia Commonwealth University Nutritional Supplementation with Chlorella for Syndrome X

18:00 - 18:30 Speaker Panel Prof Dan Z Reinstein Prof Dr Bernard Weber Prof John G Ionescu Dr Carlos Evangelista Prof Randall E Merchant 18:30 Exposition Closes - 2010 Conference Ends

Please note this programme may be subject to change

1213 13 7th Annual Anti Ageing Conference London 2010 (AACL2010) Accreditation Programme for Saturday, September 11th, 2010 CPD & CMA Accredited 14:30 Begin Afternoon Session 12 Hrs Continual Professional Development & Complimentary Medical Association 14:30 - 15:00 Lecture CPD & CMA credits Prof Dan Z Reinstein MD MA(Cantab) FRCSC DABO FRCOphth Professor Reinstein is a GMC registered specialist in ophthalmology in the United Kingdom, equally certified by the American Board of Ophthalmology and the Royal College of Physicians and Surgeons of Canada. Clinical The CPD Certification Service (CPD) is totally committed to best practice and constantly practice at the London Vision Clinic. strives to provide those professionals who access CPD via its members, with a constantly Setting the clock back on ageing eyes: treating presbyopia by laser eye surgery high level of support. 15:00 - 15:30 Lecture Contact details: CPD Certification Service Prof John G Ionescu PhD The Coach House, Ealing Green, London, W5 5ER He is Scientific Director and founder of the Spezialklinik Neukirchen for the treatment of allergic, skin and environmental diseases according to the principles of nutrition and environmental medicine. After graduating in Tel:0208 8840 4383 Biochemistry and Immunology at the University of Bucharest he specialized in Medical Biochemistry at the University of Saarbruecken in Germany and he directed a research program in a dermatological clinic in www.cpduk.co.uk Aschaffenburg. His main research areas include atopic diseases, psoriasis, arthritis and the MCS-syndrome. How to assess an anti-inflammatory diet (CMA) CPD Accredited 15:30 - 16:00 Speaker Forum 12 Hrs Complimentary Medical Association (CMA) CPD credits Moderator - Professor Syed Haq 16:00 - 16:30 Afternoon Tea/Coffee The Complementary Medical Association’s (CMA) primary aim is to promote ethical, 16:30 - 17:00 Lecture responsible, professional complementary medicine to the public and the medical profession. Dr Carlos Evangelista MD We believe that by promoting the CMA and its members through the media we are able to Coordenator of the geriatric orthopaedic unit of Orthopedic Hospital of Santana. Anti-Aging Articular Process help the public and doctors to realize that complementary medicine (CM) is - when delivered safely and ethically - a viable and highly desirable form of treatment.

17:00 - 17:30 Lecture In addition, here at the CMA, we are totally dedicated to representing “the professional face of complementary medicine”and by promoting research, education and knowledge in the Prof Dr Bernard Weber A medical doctor and CEO of Laboratoires Réunis, a private medical laboratory based in Luxembourg, Europe. field, we will help to stimulate demand for the medicine of the 21st century and beyond. Laboratoires Réunis is a national leader in the field of predictive genetics and molecular diagnosis of infectious diseases and is ISO 15189 accredited since 2006. In the last five years Dr Weber and his team have developed and validated a unique panel of phenotypic and genotypic markers which constitute a very important tool for the Contact Details: Complementary Medical Association integrative approach of multifactorial and environment linked diseases. Professor Jayney Goddard, President Genetic Analysis of Different SNPs as Potential Biomarkers in Colorectal Cancer 67 Eagle Heights, The Falcons, Bramlands Close, London, SW11 2LJ 17:30 - 18:00 Workshop Tel: 0845 129 8434 Prof Randall E Merchant PhD email: [email protected] Professor of Anatomy & Neurobiology Virginia Commonwealth University www.the-cma.org.uk Nutritional Supplementation with Chlorella for Syndrome X (CMA) CPD Accredited 18:00 - 18:30 Speaker Panel Name: ANTI-AGEING CONFERENCE LONDON 2010 Prof Dan Z Reinstein Prof Dr Bernard Weber Start Date: 9th September 2010 Prof John G Ionescu Dr Carlos Evangelista Duration (days): 3 Prof Randall E Merchant Finish Date: 11th September 2010 Type: Clinical 18:30 Exposition Closes - 2010 Conference Ends Category: External Credits: 12 Please note this programme may be subject to change Venue name: Kensington Town Hall Venue Locality: LONDON Contact Email: [email protected] Organisation: ANTI-AGEING INTERNATIONAL LTD Contact Tel: +44(0) 7973173478

1213 13 AACL 2010 Peer Review

1415 15 2010 Peer Review Board Members

Dr Robert Goldman MD PhD FAASP DO FAOASM Chairman, American Academy of Anti Aging Medicine and Founding President, National (USA) Academy of Sports Medicine.

Dr. Michael Klentze MD (PhD) Medical Director, Klentze Institue of Anti-Aging, Munich, Germany. ABAAM Director A4M, USA Secretary General ESAAM, Vienna.

Dr Julian Kenyon MD Founder President of the British Society of Intergrated Medicine (BSIM). Founder Chairman of the British Medical Acupuncture Society. Medical Director of the Dove Clinic for Intergrated Medicine, London,Winchester. His main clinical interest is complex illnesses particularly cancer and Chronic Fatigue Syndrome. His research interests centre around physics and mathematics of subtle energies.

Phil Micans MS PharmB Phil Micans has British qualifications in pharmacy, biochemistry and food and vitamin technology. Editor to the Antiaging Magazine, Chairman to the Monte Carlo Antiaging Congress and co-writer of the New Millennium Guide to Antiaging Medicine, he also maintains the position of Vice President at International Antiaging Systems.

Dr Fritz H. Bach MD Professor of surgery at Harvard Medical School and Beth Israel Deaconess Medical Center and director of the Immunobiology Research Center, known for his research on the gene heme oxygenase-1 (HO-1), which helps transplanted organs defend themselves from attacks by their recipients’ immune system. 1st to do a successful matched Bone Marrow Transplant.

Dr Fouad I. Ghaly MD FCCP A graduate from the University of Alexandria Medical School, Egypt then completing his residency at Johns Hopkins Hospital in Baltimore, Maryland. His own heart attack changed his expertise from cardiovascular anesthesiology to the practice of longevity medicine.

Dr Marios Kyriazis BA MD MSc DGM MIBiol CBiol Gerontology from the King’s College, University of London, as well as a postgraduate qualification in Geriatric Medicine, granted by the Royal College of Physicians. Chartered Biologist for work in the biology of aging. He is the founder and medical advisor to the British Longevity Society.

1415 15 2010 Peer Review Board Members Dr Aubrey de Grey PhD Department of Genetics, University of Cambridge, UK

Dr Michael Perring MA MB B.Chir FCP(SA) DPM UKCP Registered Psychotherapist Certified member of the American Academy of Anti-Aging Medicine, is registered as a practising psychotherapist and is accredited by the British Association of Sexual and Marital Therapists of which he is a founder member. He is a Council member of the Independent Doctors Forum and Chair of its Regulations Committee. He is Chair to Council of The Scientific Exploration Society, a Charity supporting conservation and promotion of youth in science.

Dr Jennifer Krup Dr. Jennifer Krup has over 23 years experience and acts as the medical director of RejuvinAge Medical Institute for Anti-Aging in Virginia Beach, Virginia, U.S.A. She is a member of the American Academy of Anti-ageing Medicine. Dr. Krup has published numerous articles in the field, with special interest in Skin and omen’sW Natural Hormonal Balance.

Dr Rajendra Sharma MB, BCh, LRCP & S(I), MFHom Dr Sharma qualified as a doctor in 1984 and has practised Integrated Medicine for the last 20 years. He has practiced in Europe, India and the USA and is now the Medical Director of The Diagnostic Clinic, London. He is the Secretary of The British Society of Ecological Medicine and was Medical Director of The Hale Clinic, Europe’s largest CAM centre.

Professor Giovanni Scapagnini MD PhD Assistant Professor, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy Assistant Professor, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville (MD), USA Visiting Professor, Institute of Human Virology, University of Maryland, Baltimore (MD), USA

Dr Patrick Kingsley MD Fellow of The American Academy of Environmental Medicine, Founder Member of the British Society of Allergy, Environmental and Nutritional Medicine, and the British Society of Integrated Medicine. His main clinical interests are Multiple Sclerosis and Cancer the natural way.

Professor Syed Haq MBBS BSc PhD DIC MRCP(UK) Dr Haq is an Associate of Plastic Surgery Associates UK, London. His expertise extends within the areas of Anti-ageing and Wellness Medicine, Molecular Biology, Internal Medicine and Non-invasive aesthetics/cosmetics. His extensive experience has been obtained through training at some of the foremost institutions in the United Kingdom - Guy’s and St.Thomas’s Hospital, Hammersmith and Royal Brompton Hospitals, and in the United States - Massachusetts General Hospital, Harvard Medical School, and Tufts University, New England Medical Center Hospitals Inc., Boston MA. 1617 17 2010 Aesthetic Peer Review Board

Mr Raj Ragoowansi Awarded several research and clinical grants from the British Association of Plastic Surgeons and British Society for Surgery of the Hand to study the molecular mechanisms and treatment of abnormal scar formation.

Mr Jonathan A Britto BSc(Hons) MB MD FRCS(Plast) Consultant Plastic and Craniofacial Surgeon - St Andrew’s Centre for Plastic Surgery and Burns, Mid-Essex Hospitals Trust, Broomfield Hospital, Chelmsford, Essex

Professor Matteo Tutino MD Creator & Founder of Modas, a all Hydroquinone-Free Controlled pH Skin Care System

1617 17 Who is a Board Member?

Peer Review Board Members are committed medical professionals at the doctoral level who have extensive experience in and are dedicated to advancing Preventative Healthcare, Anti-Aging Medicine and the advancement of science in the 21st Century. PRB members are highly respected by their peers in the field, holding multiple Directorships in International Academies and Associations, contributing to the cause through their service, speaking and publishing.

What is the Peer Review Board’s Purpose? To advise on an independent, highly ethical, non biased, non commercial basis of how to select the latest scientific research to be presented to their peers, develop educational programmes that are ACCME and CPD approved according the criteria and standards of each country’s providers of continuing medical education.

What is the Peer Review Board Member required to do?

* Annually review and keep up to date on the latest medical research in the field to find peer reviewed publications, proven practices and protocols. Based on this: * Recommend Speakers, Topics and Conference Themes. * Ensure that all recommendations put forward are individually validated according to credentials, peer review criteria and potential for contribution through speaking. * Once validation is complete, candidates put forward will be chosen based on compliance with ACCME and CPD criteria for CME accreditation.

What are the Criteria?

* Academic credentials * Professional experience * Past Speaking experience * Peer Reviewed Publications * Value of scientific and clinical contribution

Who Benefits?

* Physicians from every Medical Discipline * Scientists * Nutritionists * Gerontologists * Chiropractors * Pharmacists * Pharmaceutical Chemists & Research Specialists * RNs/Nurse Practitioners * Naturopathic Doctors * Dentists * Bariatricians/Weight Management Specialists

1819 19 AACL 2010 Speakers Speaker Presentations can be accessed at: http://www.antiageingconference.com/speakers2010

1819 19 Simon Agius Consultant to the Natural Products Wellness Sector Simon Agius, has had a diverse 12 year career in the Natural health, Anti aging & Biochemistry sector and is currently the CEO of This is Natural.com, a Natural Products Marketplace that is currently in it is BETA 2 release version Since 1998, Simon Agius has been a participant in the Natural Products and Wellness Sector in a variety of positions.

Between 2004 and 2007, Simon worked alongside Dr. Bill Elliot Cham and Curaderm Global Ltd, the Biochemical manufacturer of Curaderm-BEC5. Simon has also been engaged with a variety of companies in the Natural products, Cosmetic and Nutraceutical ingredients sector of the United States, Japan, United Kingdom and his childhood home of Vanuatu. Simon has had several articles published on the subject of Tamanu oil, which he was one of the marketing pioneers. Tamanu is currently one of the fastest growing natural oil products gaining popularity in the United States and beyond. Simon Agius is currently employed as a Educator, Marketer, Market research, Botanical research and Consultant to the Natural Products industry as the CEO of ThisisNatural.com.

Curaderm-BEC5 in 2010, the Past, Present and Future of a Clinically Proven, Non Melanoma Skin Cancer & Keratosis Cream Treatment

This paper explores, from a consumers/clinical observers perspective, a review of the most important areas of scientific and medical evidence that demonstrates the clinically proven success of Curaderm-BEC5 for the treatment of malignant and non malignant, non-melanoma & keratosis skin cancer cream. Curaderm-BEC5 is a 98% natural cream formulation first published by Dr. Bill Elliot Cham in 1980 and made commercially available, under patent, since 1990.

The paper begins with a summary of the “marketing hype” of Curaderm-BEC5 as presented on internet websites world wide. There are several consistent themes of benefits made available by the manufacturer and mentioned within tens of thousands of websites. Therefore, a standard list of clinically relevant user information, in layman’s terms, will be presented.

The how question is then immediately explored. Specifically, the unique and ground breaking discovery that glycoalkaloids solasodine glycosides (BEC) causes the death of cancer cells without affecting normal cells. The presenter will show the unique mode of action discovered by Biochemist Dr. Bill Elliot Cham and his team of researchers at the University of Queensland and subsequently independently verified by a myriad of scientists and biochemists world wide.A secondary aspect of the how will also be explored, specifically, how does one use Curaderm-BEC5. The steps of a usual Curaderm treatment will be explained within the perspective of the unique Mode of Action. Clinical examples and published research will be shown for cases of Keratosis. Basal cell carcinoma and Squamous cell carcinoma.

Since it is politically correct to question any potential cure for cancer, the presenter will briefly summarise some other ongoing cancer research, directly related to the BEC discovery independent of Dr. Cham. Regarding specifically the success of Curaderm-BEC5 in 2010, the presenter will summarise some independent clinical reviews by respected Medical Professionals. The specific references will demonstrate why the word cancer can be used correctly when associated with the acronym of research collectively termed “BEC’’.

Finally, a few recent case studies & anecdotal testimonial by users will be presented. The paper concludes with a very recent revelation that should have Medical Professionals turning their head towards learning more about this breakthrough cream technology that was first formulated in 1980.

2021 21 Dr Roger Elie Amar

Dr. Roger Elie Amar is a French plastic surgeon graduated from University of Paris France. He has been assistant professor in Anatomy and assistant professor in Plastic and Reconstructive Surgery in Marseilles, France. He is an active member of French societies: the French Society of Plastic and Reconstructive Surgery (SOF.CPRE) and French college of Plastic and Reconstructive Surgery. He was a founding member of the French society of aesthetic plastic surgery (SOFCEP).

Dr. Amar is an active member of the American Society for Aesthetic Surgery (ASAPS) and the Spanish Society of Aesthetic Plastic and reconstructive surgery (SECPRE). He is the author of three medical books in MASSON Paris (in French), Reconstruction Mammaire 1978, ABC de Chirurgie Plastique et Esthétique 1981, Les Greffes de Peau- Biologie et Technique 1985. From 1997, Dr. Roger Amar has developed the FAMI Technique (Fat Auto-Graft Muscle Injection) for facial rejuvenation. It was a total change in the classical concept of Fat injection with organic pan-facial rejuvenation at once. FAMI is offering longevity and predictability with grafts injected safely into the mimic muscles with adipose mesenchymal stem cells. After hundred of patients operated successfully and the progress of his own research on adipose stem cells the FAMI technique can challenge any invasive surgery of the men or women faces. This procedure consists of an autograft of adult stem cells from the patient’s own fat in order to restore muscle and bone surfaces FAMI offers natural rejuvenation without scars, avoiding in many cases face-lifting and blepharoplasty. FAMI can be used to correct physical muscular defects of the face or body.

Cell therapy for facial rejuvenation (F.A.M.I.) Fat autograft muscle injection

Background – Described by many authors, facial fat grafting has been largely limited to the subcutaneous plane with vague reference to injecting into the muscular planes. The technique FAMI specifically targets tissue planes and the individual muscles of facial expression to engraft adipose tissue and the mesenchymal cells within lipoaspirates. Methods – case presentation selected from a 10-year experience of hundred of patients. Results – Single, rarely two sessions of the FAMI technique resulted in marked improvement in facial volumes and contours. Conclusions –The FAMI technique for pan-facial rejuvenation provides an improved method for restoring the atrophic effects of aging and has application for other defects caused by development, disease, and trauma

2021 21 Eric R Braverman Dr. Eric Braverman is the Director of The Place for Achieving Total Health (PATH Medical), with locations in New York, NY, Penndel, PA (metro-Philadelphia), and a national network of affiliated medical professionals. Dr. Braverman received his B.A. Summa Cum Laude from Brandeis University and his M.D. with honors from New York University Medical School, after which he performed post-graduate work in Internal Medicine with a Yale Medical School affiliate in Greenwich, CT. Dr. Braverman is a recipient of the American Medical Association’s Physician’s Recognition Award. In addition to private practice at PATH Medical, Dr. Braverman maintains Directorship of The PATH Foundation, a nonprofit research organization established to collect and analyze information concerning the diagnosis, prevention, and treatment of all aspects of brain biochemical disorders, with specific focus on the impact of brain illness on overall health. ATHP Foundation projects, conducted with affiliated associates, have yielded revolutionary research documenting that brain disease or genetic weaknesses significantly contribute to psychiatric disorders. The PATH Foundation also has been intensely involved in the development of both clinic-use and at-home therapies dedicated to improving the health of the brain.Dr. Braverman has published over one hundred research papers and has participated in collaborative efforts with internationally recognized researchers. He also has published several books for the health-conscious readership:

The PATH Wellness Manual: This is a user’s guide for the body, covering ailments from A to Z and alternatives to drug approaches for most. A comprehensive medical encyclopedia that should be part of every household’s and medical professional’s reference library.Hypertension and Nutrition: How to relieve yourself of medications for high blood pressure by using diet and nutritional supplementation. Construct a customized program by following the easy-to-use instructions. In addition to using the delicious and well-balanced recipes, you will be able to dine out!The Edge Effect: Explains brain chemistry and how to achieve the Edge Effect. Explains how proper balancing of the four primary neurotransmitters can lead you to the path of health and wellness. Offers advice on honing your edge through The Rainbow Diet, exercise, hormones, vitamins, medications and lifestyle based on individual brain temperament. This book helps determine the dominant biochemical in an individual’s brain which can be the key to health self-discovery. Addresses specific ailments and how they can be treated or slowed down in terms of basic brain health.How to Lower Blood Pressure and Reverse Heart Disease Naturally: An excellent companion to Hypertension and Nutrition, this book reviews the medical research behind Dr. Braverman’s all-natural approach to combating high blood pressure and heart disease. Get control of your overall health without resorting to medications that pose a potential health threat. Obesity is the number one cause of hypertension.The Healing Nutrients Within, 2nd and 3rd Ed., with Drs. Pfeiffer, Blum, and Smayda: Find out how amino acids can be a key to restoring optimal health. Twenty-nine pre-proteins are essential to neurotransmission, brain function, immune response, hormone release, stabilization of blood pressure and blood sugar, detoxification, and wound healing, among many other functions. Male Sexual Fitness: Why libido can decline in men over the age of 30, and how to get it back. Obesity contributes greatly to sexual dysfunction.

Zinc and Other Micro-Nutrients, by Dr. Carl Pfeiffer with Dr. Eric Braverman: The definitive guide to how minerals have the potential to heal illness. Explains why some minerals are bad for you and how to rid your body of them.

Hormones and the Brain

Cognitive decline and development of dementia is now recognized to be multi-factorial. The presence of medical illnesses can damage cognition i.e. atrial fibrillation, diabetes, thyroid disease, heart failure, inflammation, high blood pressure, smoking and other illicit drug use, elevated cholesterol and any cardiac disease or vascular risk factors have all been linked to progression of dementia,

2223 23 which takes at least 10-20 years to develop. There are at least five stages of cognitive decline prior to dementia with numerous variations. Typically dementia begins with the following order of losses: brain processing speed, memory, attention, personality and temperament change, IQ changes, and ultimately dementia.

Furthermore, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient. Hormonal deficiencies that are linked are: Growth hormone beginning from age 30 in both men and women, estrogen lossbeginning at age 40in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50. The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age.

A wide range of medical and psychiatric illnesses including depression are contributing to the progression of dementia which occurs in most Americans between the ages of 50 and 80 such that 50% of all Americans are fully demented by age 80. Dr. Braverman has identified the marker of the stages of cognitive decline as well as hormonal cornerstone abnormalities associated with most forms of dementia.

Leptin Imbalances and Aging - The Secret of Obesity Science

Leptin, a protein produced by neurological tissue, primarily the hypothalamus, brain stem, and adipose tissue, acts as a peripheral metabolic signal to the brain. It reaches the brain, crosses the blood-brain barrier, and accumulates in neuronal cell bodies expressing leptin receptors. This protein reduces body weight by inhibiting feeding behavior and increasing fuel expenditure. It is thus an integral component of energy homeostasis and regulation of body weight. Although it is thought that these effects are mediated by the direct action of leptin on hypothalamic neurons, recent studies have found close interactions between leptin and the D2 receptors and serotonergic system. During the aging process, there is a decline in the dopaminergic and serotonergic systems that are both activated by leptins. There is also greater adiposity despite high serum leptin levels, in part due to a reduction in the number of leptin receptors in these areas of the brain.

Aging is associated with a gradual loss of physiological functions and a decline in plasma concentrations of several steroid hormones. There is a correlation between declining estrogen and testosterone levels and low leptin levels. Aging-associated alterations in body composition, which include increased fat mass, loss in muscle size and strength, and loss of bone, are at least in part related to specific endocrine changes. In particular, individuals with elevated leptin levels develop osteoporosis, hyperlipidemia, and obesity. Extremely low leptin levels may be associated long term with oligomenorrhea, anorexia, too much thinness, and dementia. Therefore, it would be beneficial to maintain leptin levels in a middle or low range so that individuals may stay thin as they treat their brain chemistry.

Leptin is of particular importance in obesity. Although the body mass index (BMI) is commonly used as a measurement of obesity, we have found it to be an inaccurate measure of body fat. When compared to a direct measure of adiposity, the dual X-ray absorptiometry (DEXA) scan, we found that BMI misclassified nearly 40% of our patient population. We found that individuals who fell into a normal weight obesity category, with normal BMI but obesity level body fat percentage, had elevated leptin. By incorporating additional parameters such as gender and age in addition to leptin levels into the BMI formula, we found that the sensitivity and specificity of the equation were improved. Testing for leptin is a relatively inexpensive lab test that can help to predict obesity for those individuals who appear to be fit but are actually at risk for this condition. In addition, genetically low leptin patients have reduced body fat relative to BMI while genetically elevated leptin patients have elevated body fat relative to BMI.

2223 23 Constance Campion Although well known as a seasoned City analyst in the advanced rejuvenation healthcare science sectors, Constance Campion brought Wall Street logic to medical enterprise and the medical profession in 1989, when she outlined and illustrated evidence that medical aesthetics would become one of the most sought after elective areas of medicine, outstripping demand for aesthetic surgery.

Described by Vogue magazine as one of their top beauty secrets she is a respected industry leader amongst her peers due to her expert knowledge, experience and clinical expertise in advanced skin, wellness and anti-ageing. Working alongside industry, internationally acclaimed anti-ageing scientists, dermatologists and plastic surgeons, she joined her husband the renowned plastic surgeon Awad Awwad fifteen years ago and introduced non-surgical anti ageing medicine and skin health restoration, across the spectrum of the services he and his colleagues offered in plastic, reconstructive, hand and aesthetic surgery at Plastic Surgery Associates UK Bupa Cromwell Hospital, London. Due to a keen interest in advanced skin health, she has pioneered many of the concepts that are evidenced and used today and espouses comprehensive anti-inflammation and safe chiral science across the spectrum of her clinical activities and work. Always ahead in the stakes of what is to come, she opened the first Medical Spa in the UK in Kensington in 1998 and is an advocate of safe ingredients and safer, more effective technology in the beauty and medical arenas so as to safeguard patients’ long-term health.

Having initiated and served as Chairman of the first steering committee in medical aesthetics at The Royal College of Nursing, she worked for three years on the development and competency framework registration for Nurses in Aesthetic Medicine at the college, and is a Programme Education Board Member of the American Society of Plastic Surgery Skincare Specialists. A Founding Board Member of The American Institute of Medical Aesthetics, she has served as a member of the editorial board of Aesthetic Medicine and is Chairman of Medico Beauty Ltd. Regarded as a lively, entertaining and inspiring speaker, she lectures throughout the world on her chosen topics. She has four children, one of whom is an economist and works with her at her City partnership and is a fellow Director of Medico Beauty Limited. The Economics of an Ante-Ageing Practice: A Dimensional Analysis of the Relevant Increments in Healthcare and Practice Success

Over the last decade, there has been a notable surge in the number of practices and practitioners offering ante-ageing therapies and treatments. With more and more physicians transitioning to medical aesthetics, what will the impact be for the comprehensive medical science of anti-ageing medicine as a whole? The term ante-ageing medicine lacks conceptual clarity and definition. Furthermore, the qualities of the components, process, and outcomes of care have not been clearly articulated. This presentation provides a dimensional analysis of ante-ageing medicine provision, in order to elucidate the concept, and its context and consequences, as portrayed through available evidence and literature. As a method, dimensional analysis is rooted in symbolic interaction and grounded theory. As such, it provides a useful tool with which to analyze existing literature on ante-ageing medicine. In this dimensional analysis, patient treatment is the dominant perspective of ante- ageing medicine. It demonstrates that the current consequences of ante-ageing medicine are identifiable and dominated by extrinsic results, rather than the optimal intrinsic solutions that could improve the quality of life. These consequences suggest that the focus of ante- ageing medicine should be on the medical and economic benefits rather than the number of treatments and issues around the experience that excludes the advantages that rejuvenation wellness medicine can offer patients and society as a whole. 2425 25 Dr Carlos Evangelista Dr. Carlos Evangelista M.D., was born in 1957, and was graduated in 1984 from the Faculty of Medical Sciences, Lisbon University, Portugal. Always interested in orthopedics, he recived is formation in the Orthopedic Hospital of Santana,Parede,Portugal,where he has been working for the last 22 years as orthopaedic surgean. His main work has been in the area of hip and knee replacement, with particular interest in elderly patients, developing and increasing minimal invasive systems. He is member the Portuguese Orthopedic Society and the Portuguese knee Society. In the last 20 years he has developed his own private clinic, and has also been responsable since 2002 for the Clinic IMC Cascais, now CUF Cascais, orthopaedic center. Coordenator of the geriatric orthopaedic unit of Orthopedic Hospital of Santana.

Anti-Aging Articular Process

Within all the pathologies that affect individuals from the 4th decade of life, osteoarthritis is the most common, estimated to occur in 90% of the adult population. It is has old has the history of mankind. Osteoarthritis results from an abnormal process between the cartilage destruction and its repair. The basic function of joint cartilage is to reduce friction between two bone surfaces when they execute any kind of movement, functioning as a mechanism to absorb shock. To improve this mechanism, there is the synovial fluid that lubricates the joints. To maintain a good articular health we have sysadoas (Symptomatic Slowing Acting Drugs) that includes hyaluoronic acid, glucosamine and condrotine. In patients with osteoarthritis, the concentration of hyaluronic acid in synovial fluid is diminished, so the treatment called for viscosupplementation begins to become important. This process consists in a series of intra-articular injections with the aim to restore the quality and concentration of this component in the synovial fluid, improving the lubrication and shock absorption capability and subsequently reducing pain. Glucosamine and condrotine contribute to the cellular protection, condrocites protection and maintenance of the structural support of the cartilage. The author presents the recent concepts and therapeutic forms of osteoarthritis whose goal is to prevent and treat the anti-aging articular process.

2425 25 Dr Fouad I Ghaly A graduate from the University of Alexandria Medical School, Egypt then completing his residency at Johns Hopkins Hospital in Baltimore, Maryland. His own heart attack changed his expertise from cardiovascular anesthesiology to the practice of longevity medicine.

Enhanced External Counterpulsation (EECP): A Non- Invasive Out Patient Procedure to Revascularize the Heart Muscle without Open Heart Surgery.

The heart and cardiovascular system play such pivotal roles in maintaining our overall health and fitness that taking measures to insure heart health is vital to any anti-aging or longevity program. In a 2005 study published in Heart Failure Monitor, Gielen, et al noted the striking similarities between aging and chronic heart failure, including “exercise intolerance, reduced cardiac functional reserve during exercise, and loss of skeletal muscle mass as a result of inflammation and catabolism.” They also described vascular aging as a “progressive decrease in flow-mediated, endothelium-dependent vasodilation” and showed that aging of the cardiovascular system could begin in individuals as young as 25-35 years of age. In addition, Lakatta and Levy state in a 2003 paper published in Circulation, “There is a continuum of expression of cardiac structural and functional alterations that occurs with age in healthy humans, and these age-associated cardiac changes seem to have relevance to the steep increases in LVH, chronic heart failure, and AF seen with increasing age.” It is clear that taking steps to maintain cardiovascular health is an essential component of any Longevity or Rejuvenation Program. No matter how much we may wish otherwise, the fact remains that we cannot stop Time. But is there anything that we can to stop or even reverse the harmful effects that aging and atherosclerosis have on the heart and cardiovascular system? Fortunately, there is. Enhanced External Counterpulsation (EECP) is a 50-year-old, non-invasive technology that has proven to be a safe and effective alternative or complement to invasive, high-risk procedures such as angioplasty and bypass surgery. Unlike these conventional treatments that target individual blockages, EECP treats heart disease as chronic system-wide illness. By recruiting and helping to develop new collateral blood vessels, EECP maximizes blood flow to the heart, as well as throughout the entire body.

2627 27 Ms Galina Imrie Galina Imrie MA Ed is Founder of the International Register of Integrative Colon Therapists and Trainers (www.rictat.org); Principal of the Chi Centre for Practical Detoxification and Aqua-Clinic Colleges; and author of published books, articles and manuals on integrative colon hydrotherapy and rejuvenation through neuroendocrine, digestive and immune support of the large bowel. Her best known popular book: “Always Look After Number Two, Discover the Secrets of Colonic Irrigation, Perfect Bowel Movements and Digestive Health” , is now recommended by some general practitioners to their patients. Galina is regularly invited to speak at conferences, shows and seminars on complementary medicine and integrative healthcare.

Colon Hydrotherapy and the Chemistry of Wellbein

The large bowel, a somewhat under-researched organ, plays an important role in the quality of life and maintenance of health as we age. With around 95% of our neuro-hormone of wellbeing, serotonin, being produced it the large intestine, we should always be able to rely on a well-functioning bowel to keep us happy and make sure the toxic load is effectively removed from the body. However, our longer lifespan is often accompanied today by age-related slowing of the function of the large intestine. Such common factors as

* an increase in the transit time; * a reduction in general physical fitness; * 5-HT depletion; * oxidative damage by the ROS due to prolonged exposure to toxic compounds in the stools; * dietary changes resulting in lower-residue diets; * the building of “water debt” and other factors

cause not only slow-transit constipation but also cell dehydration, reduction of muscle tissue elasticity and deformability and other more serious degenerative conditions such as diverticulosis and diverticulitis and colorectal cancers. Doubts are now being cast on the effectiveness of high-fibre diets in mitigating the age- related degeneration of the digestive function. Contemporary colon hydrotherapy, a controlled and measured release of water into the rectum with the purpose of rehydration of the large intestine and repayment of the “water debt”, can also boost serotonin production, accelerate transit time and reduce damage caused by the reactive oxygen species by means of removing excess toxic load and supporting the immune system in the large intestine. This also restores the subjective sense of wellbeing in an individual and sense of increased energy, which, in turn, helps increase mobility and maintain a healthy attitude to life.

2627 27 Prof John G Ionescu Prof. Ionescu is Scientific Director and founder of the Special Clinic Neukirchen, Bio-Data and Energy Cosmetic companies, located in 93453 Neukirchen, Germany. After graduation in biochemistry and immunology at the University of Bucharest, 1976 and a scientific fellowship in Montreal, Canada, he wandered to West-Germany and established there since 1980. He received his PhD in medical biochemistry 1983 from the University of Saarbrücken, Germany, and directed until 1985 the research programme of a dermatological clinic in Aschaffenburg. Main research areas included the atopic diseases, psoriasis, arthritis and the MCS-syndrome. Prof. Ionescu founded 1986 in Bavaria the Special Clinic Neukirchen for the treatment of allergic, skin and environmental diseases according to the principles of the nutritional and environmental medicine. The 160 bed facility is fully integrated in the official hospital system and the treatment fees are reimbursed by all German and Austrian health insurances. The original diagnostic and therapeutic approaches of his cortisone-, cytostatic- and radiation-free concept have been reported in more than 140 scientific publications in Germany, Europe and USA. Current work involves the investigation of biological redox systems and free radical reactions in skin, environmental and cancer patients. His research results are subjects of new methods for the rapid free radical and redox potential assessment in human blood samples, new dermatological formulations for the diseased and aging skin, patented anti-cancer drugs and original integrative protocols for the treatment of MCS, CFS and chronic dermatoses. Prof. Ionescu is member of the European Academy for Allergology and Clinical Immunology, of the British Society for Allergy and Environmental Medicine and of the American Academy of Environmental Medicine. As Scientific Director he is also active in the Board of the International Oxidative Medical Association (USA) and of the NRW Multiple Chemical Sensitivity Association (Germany). Since August 1998 he was nominated as Professor for Clinical Biochemistry and Oxidology at the Capital University of Integrative Medicine, Washington, D.C. (USA). Prof. Ionescu is also member of the Editorial Board of the Journal of the Capital University of Integrative Medicine.

How to assess an anti-inflammatory diet

Our experience in the treatment of over 20,000 atopic eczema, urticaria and psoriasis patients shows that besides allergic reactions to foods an increasing number of pseudoallergic reactions caused by toxic-irritative pollutants (formaldehyde, exhaust particles, additive-rich food, nicotine, wood preservatives, pesticides, heavy metals) are responsible for the inflammatory process behind the complex symptoms. Intrauterine and postnatal environmental influences were also reported. The routine analysis of specific IgE- and IgG4-factors in our atopic patients by means of ELISA-assays after challenge meals (CM) showed an increased frequency of specific IgE- and IgG4-antibodies after repeated CM. In 60% of the patients, we simultaneously found raised concentrations of the IgE- and IgG-CIC (p< 0.005) responsible for the delayed allergic reactions in the same group. Further inflammation markers like acute phase proteins (a1‑antitrypsin, a2‑makroglobulin, haptoglobin and caeruloplasmin) showed a surprisingly rapid increase after CM (p< 0.01) in the atopic group; by contrast the control samples remained in the normal range. Serum histamine levels (RIA-Test) also showed a significant increase 1/2 hour after

2829 29 CM and after individual oral provocation with lactose, sucrose, tyramine, serotonine or phenylethylamine, respectively. The carbohydrate intolerance reactions (H2-test) were in good correlation to the significantly lowered disaccharidase activites (lactase, sucrase) in the gut of atopic eczema patients (p< 0.001). This was closely related to chronic intestinal dysbiosis with toxic microbial breakdown products (alcohols, aldehydes, phenols, diamines) leading to an increased intestinal permeability, histamine release and impairment of liver detox functions. On the other side, we found both in atopic eczema and in psoriasis patients pseudoallergic reactions against biogenic amines and constantly raised serum histamine levels (also in fasted patients), suggesting an inhibition of catabolic enzymes (MAO, DAO, NMT). Previously published results from our laboratory showed significantly reduced DAO (p< 0.001) and Type B MAO- (p< 0.05) activities in thrombocyte-rich plasma of atopic eczema and psoriasis patients explaining their intolerance reactions to histamine, tyramine and octopamine rich foods. Last, but not least, the chronic increased levels of free radicals in whole blood and plasma of all patient groups showed significant changes after oral intake of different food homogenates/ juices dependent on their ROS-blocking or ROS-increasing effects (enhanced chemoluminescence test). Our current research shows that appropriate combinations of hypoallergenic protein hydrolysates with particular sugar alcohols and omega-3 fatty acids (Equiderm Plus®) are dramatically enhancing the anti-inflammatory and free radical quenching properties of the mixture, demonstrating an excellent compliance and therapy efficiency in atopic, psoriasis and geriatric patients. With the emergence of affordable microarray gene expression profiling methods, the opportunity arises to ex-vivo test certain combinations for their silencing ability on inflammatory genes before administering the nutraceutical to the patient (nutrigenomic evaluation). The input of the above mentioned nutritional data in a computer supported, individual rotation diet plan (Food Allergy Control®) ensures a gradual improvement of the symptoms and stabilization of the clinical course during and after therapy.

2829 29 Prof Dr Bernd Kleine-Gunk Euromed Clinic, Fürth, Germany - President of the German Society of Anti-Aging Medicine (GSAAM)

Prof Kleine-Gunk studied medicine at the University of Munster and Essen from there he went onto complete his PhD at the Essen Institute for Tumor Research .He became assistant Physician in the department of Gynaecology at the Elizabeth Hospital in Essen. From 1988-1990 he worked in Zimbabwe as Director of the district hospital in Gokwe as part of Medical Development aid in Zimbabwe Africa. On returning to Germany he became approved as a Gynaecologist and setup laparoscopic surgery. Since 1994 he has been Chief Physician of the Gynaelogical Department at the Euromedical Clinic in Nurenberg Furth. He has added Nutritional Medicine and Osteologist by DVO to his levels of Medical expertise. He is a founding member of the European Centre of Aging Research and Education (ECARE), a member of the German Menopause Society and President of the German Society of Anti Aging Medicine (GSAAM).He has both written and contributed to numerous national and International medical publications.

Anti-Aging - The first 4000 Years

A common prejudice against anti-aging medicine is this: It was created in the 1990s, is more a short-lived fashion than a serious field of medicine and the hype is more or less already over.

The exact contrary is true: Anti-aging is one of mankind’s oldest dreams; and anti-aging medicine is as old as the history of healing itself. Already the first known literary document – the sumeric Gilgamesh Epos (ca. 2500 B.C.) – has as its main topic the quest for longevity. Ancient egyptian papyri contain chapters like “How to turn an old (man) into a young (man)”. In China a whole religion – Taoism – was devoted to the quest of longevity.

Lifestyle and esthetic medicine also has its ancient roots. Hippocrates, the father of western medicine, incorporated a number of formulas “against wrinkles” and “to give the face a nicer appearance “ into his work on female disease.

Leading figures of scientific and medical history like England’s Francis Bacon, the founder of the Royal Society, Germany’s C.H. Hufeland, personal doctor to J.W. Goethe, or America’s Benjamin Franklin have devoted much of there work to the question of how to prolong life in a healthy way. The history of endocrinology and hormone replacement therapy is from its very beginnings closely connected with the fight against the process of aging.

For a long time the age-old quest for longevity seemed as futile as another old dream of mankind: to learn how to fly. However, the 20th century saw the last dream come true. Chances are that the 21st century will see the other dream – that of eternal youth – being fulfilled as well.

3031 31 Dr Hansjörg Lammers Dr. Hansjörg Lammers, DMD, PhD, Holistic Dentist for Environmental Medicine, studied holistic dentistry at the private university of Witten/ Herdecke in Germany from 1985-1990. He is a practicing dentist with focus on environmental medicine, lecturer, author and a developer of nutraceuticals since 1991. Moreover he is the adviser of the medical society for comprehensive biological therapies at own international conferences since 9 years. Dr. Hansjörg Lammers is the head of the Anti-Aging- & Preventive Medicine-Department of several private clinics in Germany and the UAE. In 1995 he founded the Institute for Integrative and Preventive Medicine (IIPM) in Germany for the support of detoxifying treatments in all chronically diseased patients. He is the medical and scientific director of the IIPM.. Publications: More than 80 papers, scientific articles and contributions to books in the last 9 years

Metal-Free Dentistry to Avoid Arteriosclerosis and Cancer

There are several important concepts regarding the initiation of arteriosclerosis. One of these is that arteriosclerosis results from the infiltration of the endothelial lining of the arteries with toxic heavy metals, like lead and mercury. The inner lining of the artery is the side where the important vasodilatator substance nitric oxide is created. The endothelium also produces prostacyclin which decreases clotting of blood and causes dilating of arteries. A third important substance is heparin, a potent substance that prevents clots from forming. Excessive deposition of heavy metals in the endothelium diminishes the endothelium`s ability to produce valuable nitric oxide, prostacyclin and heparin. Removal of these toxic metals restores the endothelium`s ability to produce these vital substances which stops and may even reverse arteriosclerosis. Heavy Metals and Cancer Metals can directly and indirectly damage DNA through free radical stress and that means an increased risk of cancer (=genotoxicity). There are also possible non-genotoxic pathways, due to irritation (changing of the cell-millieu) or immuno-toxicity.

Goals & Objectives at least 3 goals & objectives required

1. Get an update on the advantages of metal free crowns, bridges & implants (zirconiumdioxide) 2. Discussion in limiting and detoxification of a heavy metal load 3. Get highly informed on how to protect the body for a toxic burden (cumulative effects of poisons)

3031 31 Dr Zulya Maizetova Dr Maizetova received her medical degree and her Masters in Dermatology at the Medical University of St Petersburg .Dr Maiztova has an integrated method of prevention and reversal of skin aging through specific treatments to improve the body’s own ability to regenerate itself. This method is safe , non-toxic and non –invasive. Dr Zulya Maizetova uses her successful integrated medical approach to treat and prevent skin diseases and aging, allergies, weight problems, environmental and heavy metal toxicity ,hair loss and many other ailments.

Resveratrol - A real benefit or just a conundrum

Genetic polymorphisms and their correlation with phenotype heterogeneity in 100 subjects with chronic cerebrovascular disease in the Grand Duchy of Luxembourg. Laboratoires Réunis, Junglinster, Luxembourg; 2 Centre Hospitalier de Luxembourg, Luxembourg

Cerebro-cardio-vascular diseases are estimated to be the leading cause of death and loss of disability-adjusted life years. In the present study, 25 patients received intensive lifestyle advice, 25 received intensive lifestyle advice plus the advice to drink a glass of red wine each day, 25 received the advice to drink only a glass of red wine each day, and the remaining 25 followed their usual lifestyle.

The genetic analysis was carried out to explore the importance of a number of single nucleotide polymorphisms (SNP) located in several genes, which are related to energy expenditure, adipogenesis, insulin resistance, blood pressure regulation and body composition. The analysed SNPs were: KIF6 (rs20455), PON1 (Q192R), APOA1 (G-75A), PPARgamma (P12A), FABP2 (A54T), SELP (V640L), SELE (S149R), C5 (rs17611), ADH1C (G78X), ICAM (rs309303), C3 (rs11569562), ApoE (E2/E3/E4), TNFalpha (G-238A), CETP (G-279A), CETP (I405V) and CRP (T-717C).

We found a correlation between different patterns of SNPs and the response to diet. We could also detect SNP-dependent differences in mean systolic blood pressure in the two diet/ sports arms and a difference of the LDL/HDL ratio in the two wine arms compared to the control group.

Further analysis will give a better understanding of gene-environment interactions in metabolic pathways associated with pathological symptoms related to diet and to lack of physical activities as well as with the risk of cardiovasculer diseases, especially of cerebrovascular diseases. The purpose is to develop better target therapeutics upon individual physiological response to dietary and lifestyle habits that vary in the population and are related to different genetic backgrounds.

3233 33 Dr Miguel Martinez Dr Martinez started the exciting discovery of medicine at the University of Barcelona (Spain) and continued with further training in Obstetrics & Gynaecology together with General Practice in the UK. He obtained the Diploma in Aesthetics & Anti-Aging Medicine from the University of Barcelona that led to the European Anti-Aging Medicine Speciality in Brussels (Belgium) and Paris (France).

A Protein Diet: An efficient and scientific weapon for weight loss

Discover in a scientific and safe way how to loose between 5 to 10 kg of weight per month without being hungry and yet feeling full of energy. This is possible nowadays depending on your age and gender. The presentation will inform and educate you .

* Length of diet (not life long) * To loose weight (not balanced diet) * Scientific, safe, effective * Not hungry, full of energy

Achieving your ideal weight will reduce the risks developing chronic diseases eg cardiovascular, cancer risk and Type 2 diabetes

Seminar - Bio-identical hormones - The effect of nutrition on hormone balance

Objectives

To learn a practical method to balance endogenous production of insulin and glucagons. Understand how to avoid diet induced hyperinsulinaemia and hyperglycaemia and its effects. How to identify symptoms of unbalanced nutrition. Learn signs and symptoms of sex hormone deficiencies with bio identical hormones. Identify pros and cons of bio-identical and non bio-identical sex hormones.

3233 33 Prof Randall E Merchant Professor of Anatomy & Neurobiology Virginia Commonwealth University

Nutritional Supplementation with Chlorella for Syndrome X

Syndrome X, also known as metabolic syndrome and visceral fat syndrome, affects 20-30% of the population of industrialized countries. The syndrome is diagnosed according to specific criteria related to waistline, triglyceride and HDL levels, blood pressure, and fasting blood glucose. The incidence of Syndrome X increases directly with age until around sixty when it levels off affecting an estimated 40% of the elderly. People with Syndrome X are at increased risk for developing atherosclerosis and suffering from cardiovascular disease and stroke. To reverse these risks associated with Syndrome X, one needs to lose weight, exercise, and make dietary changes to lower the intake of salt, saturated fats, simple sugars, and low-fiber carbohydrates while increasing the consumption of fish, monounsaturated oils, and complex carbohydrates.

The incidence of Type II diabetes is high in people with Syndrome X and their hyperglycemia often requires oral medications to lower blood glucose. Drug treatment, unfortunately, often means life-long dependence on an agent that may for many patients only partially control their hyperglycemia and may also have adverse side effects. For this reason, there is a great deal of interest in non-pharmacological interventions which can better control hyperglycemia and reduce or eliminate the need for drugs.

Non-pharmacological interventions provide effective means to lower blood glucose levels and have been emphasized increasingly as a useful method in the treatment of diabetics (1,2). Dietary modifications have focused on reductions in the daily total caloric intake of foods rich in sugar and fats. Studies have also shown that foods with fiber, such as fruits, vegetables, peas, beans, and whole-grain breads and cereals may help lower blood glucose. These natural foods also tend to be particularly rich in antioxidants (e.g. vitamins C and E) which when combined with soluble fiber are believed to help limit the secondary cardiovascular complications of diabetes. This has led to the hypothesis that the combination of proteins, sugars, fats and fiber which exist together in commonly eaten “whole foods” such as fruits, nuts, vegetables, and cereals and whose intakes are, therefore, highly correlated, act in synergy to produce a hypoglycemic effect. Vegetarians whose diets are rich in fruits and vegetables have substantially lower risk of developing diabetes and hypertension than non-vegetarians (3).

Comprehensive studies have failed to uncover any specific nutrient or combination of nutrients in these diets which improves carbohydrate metabolism (i.e. a hypoglycemic effect) and rather have suggested that it is the “whole food” with its complex combination of nutrients acting synergistically that is responsible. In light of these observations, it seems reasonable to expect that daily dietary supplementation with natural “whole foods” rich in proteins, vitamins, minerals, and fiber may help control the hyperglycemia ofType II diabetics who otherwise enjoy a normal, non-vegetarian diet.

Chlorella pyrenoidosa, another example of a “whole food”, is a unicellular green alga that grows in fresh water and consists of 60% protein, 20% carbohydrate, and about 11% unsaturated fats. These proteins and carbohydrates can provide a steady energy stream to the body without spiking insulin secretion and can also suppress appetite. Chlorella has the highest content of chlorophyll of any known plant and chlorophyll is a well-known detoxifier; removing toxins stored in the body and preventing the uptake of toxins by the cells of the intestines. Chlorella also contains high concentrations of certain vitamins, minerals, dietary fiber, nucleic acids, amino acids, enzymes, and other substances. The algae have strong

3435 35 cell walls that prevent their native form from being adequately digested so that only after drying and breaking its cell wall can these organisms be digested by humans. The DYNO®- Mill processing method, used in the manufacture of Chlorella for human consumption, has proven the best method for breaking the cell wall while preserving its nutritional value.

In this presentation, a number of laboratory research and clinical trials we and others have conducted in Japan and the United States will be described which show that daily ingestion of Chlorella helps ameliorate the symptoms of Syndrome X by reducing percent body fat, blood pressure, total serum cholesterol, and fasting glucose levels (4-6). The findings of two studies among those that will be presented are described below.

In one laboratory study, a group of spontaneously obese mice were fed a regular diet and a group of spontaneously obese mice was fed a normal diet with 5% Chlorella (5). After eight weeks, the obese mice fed the diet containing the Chlorella had significantly lower body weight, blood pressure, and insulin levels while having significantly higher levels of adiponectin compared to those obese mice fed their regular diet.

Direct evidence of how consumption of Chlorella helps control blood sugar has only recently come to light. A recent clinical study by Mizoguchi and colleagues examined serum components and used a DNA microarray to examine expression of several thousand genes in white blood cells of 17 subjects diagnosed with Syndrome X consuming 8.5g of Chlorella per day for two months (6). Consumption of Chlorella led to reductions in percentage body fat, total serum cholesterol and fasting glucose levels. Gene expression analysis identified an activation of genes related to both fat metabolism and insulin signaling pathways. Variations in the expression of genes directly involved in to the active uptake of glucose before, during, and after consuming Chlorella provide an explanation for reduced serum glucose; substantiating with physiologic and genetic evidence the findings of numerous clinical studies that showed consumption of Chlorella lowered blood sugar.

Syndrome X is treated with the hope of lowering the patient’s overall risk of cardiovascular disease and its consequences. It is now a generally accepted that a combination of exercise and diet modification is the best way to accomplish this. Furthermore, there is now a substantial body of evidence that the daily consumption of Chlorella with its complex of proteins, amino acids, vitamins, and minerals may also play a role in diminishing the symptoms of Syndrome X by triggering the expression of genes of the insulin signaling pathway.

References

1. Delahanty LM, Halford BN: The role of diet behaviors in achieving improved glycemic control in intensively treated patients in the Diabetes Control and Complications Trial. Diabetes Care 16:1453-1458, 1993. 2. Garg A, et al: Effects of varying carbohydrate content of diet in patients with non-insulin- dependent diabetes mellitus. JAMA 11;271:1421-1428. 1994. 3. Beilin LJ, Burke V: Vegetarian diet components, protein and blood pressure: Which nutrients are important? Clin Exp Pharmacol Physiol 22:195-198, 1995. 4. Merchant RE et al: Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension. J Med Food 5:141-152, 2002. 5. Masuzawa T, et al: The effects of Chlorella on metabolic syndrome using spontaneously obese mice. Presented at the 81st Ann Meeting Jpn Pharmacol Soc, 2008. 6. Mizoguchi T, et al: Nutrigenomics studies on effects of Chlorella on subjects with high risk factors for lifestyle-related disease. J Med Food 11:395-404, 2008.

3435 35 Dr Valerio Di Nicola Dr. Valerio Di Nicola M.D. Ph.D, was born in Rome, and graduated in Medicine in 1989. From 1989 until 1997 he worked in Policlinico Umberto I in Rome first as an assistant during his General Surgery Residency and then during his PhD he worked in Microsurgery. In the next years he improved his skills in laparoscopic and Minimally Invasive procedures ( Fellowship of ACOI- Italian Surgeons Association-) and increased his knowledge in Coloproctology with a Fellowship in Oncological Colorectal Minimally Invasive and Open Surgery. Later he achieved a Master in the same field at the University ‘La Sapienza’of Rome. From 2006 to January 2010 he was Head of the General Surgery Department at San Marco Hospital in Latina, Italy. Currently he is a Consultant of the General Surgery Department at the Israelite Hospital of Rome. In the last ten years parallel with his surgical activities he has been working on Regenerative Medicine, after having inherited these medical experiences and clinical research from his father. Many scholars have lead in vitro and experimental studies about placenta, amnios and placental extracts as substances able to promote tissue regeneration. In the last 10 years he has developed in his own private clinic a new approach to stimulate and activate innate joint stem cells forming a favourable microenvironment in the area of articular degeneration apt to promote a tissue regeneration. In his Clinic, he has been studying and treating ultra-octogenarian patients always high surgical risk who have been non-responders to currently adopted conservative therapies. He is author of 44 publications, and his studies in “joint self-repair” have been presented in the fifth Stromboli conference and in process of publication.

Self-Repair in Degenerative Joint Disease

This study presents a method for treating and structurally improving articulations affected by Degenerative Joint Disease (DJD). The focus of this analysis is on two groups of patients (pts). The first one composed of patients over-eighties and the second group was from 45 to 55 year old pts. The first group had high surgical risk and both had been non-responders to currently adopted conservative therapies. Scholars like Davis , Filatov and Cerletti have been studying and using the regenerative properties of placenta, amnios and other non vital tissues since the early ‘900’s. These pioneering studies have opened a new track for tissue renewal. More recently, the new biological knowledge about extra cellular nucleic acids, growth factors (GF) - as by-products of trauma response - and heat shock proteins (Hsp) has helped research even further. Building on those experiences, we have developed a regenerative gel obtained with distressed, processed blood, Polydeoxyribonucleotides (Pdrn) and a thickening substance. The objective was to stimulate the local innate stem-cells with our gel in order to induce tissue repair. From 2003 until 2009 we treated 948 pts. As mentioned, the first group was composed of 86 ultra- octogenarian pts with severe osteoarthritis (OA) of the hip and/or knee, and the second group was composed of 90 young pts (around fifty year old) affected by the same disease. Treated patients have been clinically and radiologically evaluated with a follow-up of 6 to 48 months. Results show a statistically significant improvement in terms of pain and joint mobility, sometimes coupled with a clear radiological improvement. Follow-ups show encouraging data in terms of clinical stability over time. During the study we encountered virtually no side effects, adverse reactions or toxicity. Currently the pharmacological treatment of DJD is palliative. It has toxicity and side effects. Patients that can be operated conclude their trial with a prosthesis followed by a long rehabilitation period. This study suggests a new methodological approach and treatment of DJD based on tissue regeneration and restoration resulting in clinical resolution.

3637 37 Mr Noel Thomas Patton

Noel Thomas Patton, founder of T.A. SCIENCES®, was born and raised in Fort Wayne, Indiana. His boyhood upbringing was a far cry from the breakthrough Biotech business he is engaged in today. Just as T.A. Sciences® is a hybrid of Traditional Chinese Culture and modern science, so is Noel Patton’s life which has included impressive business success both in America and China. A graduate of Indiana University (1969) with an Honors Degree in Philosophy, Noel furthered his studies on the East Coast and is an alumnus of the Harvard Business School. He maintains an ongoing involvement with Young Presidents Organization (YPO) through its CEO and WPO graduate organizations. In 1972 Noel purchased Patton Electric Company, the family appliance manufacturing business started by his father in 1945. By the mid 80’s Patton Electric and many other US manufactures were facing fierce competition from low cost imports. In 1987 he moved with his family to Hong Kong, China, which was just opening up after Mao’s Cultural Revolution. As always a pioneer, Noel was a presence even in rural China at a time when no small American company had yet ventured into that territory. As Noel and his family thrived in the adrenalin-charged culture and sophistication of Hong Kong and China, the business flourished. In 1995 Patton Electric Company was sold to a large publicly traded appliance firm. At this time, Noel began to indulge his passion for knowledge of new developments in age management and the latest breakthroughs in biotechnology. In particular, he began to explore the intersection between Traditional Chinese Medicine (TCM) and Western medical science. In 1999 Noel heard Professor Jerry Shay of the University of Texas Southwest give a speech about a naturally occurring enzyme called telomerase that made human cells “young” again. Meeting Dr. Shay was Noel Patton’s introduction to the newly evolving scientific world of Telomere Biology. Noel immediately followed through and contacted leading edge California biotech company Geron Corporation, the industry leader in developing this new scientific frontier. And so began a tremendously positive and rewarding business relationship. Noel and his wife Eve invested in Geron and began helping this California-based firm to expand into Hong Kong. The Pattons were on hand when Geron and the University of Science and Technology in Hong Kong discovered the cellular rejuvenation properties of the single molecule which we now call TA-65. TA-65 is a naturally occurring, but very rare, molecule found in the well known Astragalus plant. In 2002 Noel and Eve secured exclusive worldwide rights to Geron’s Telomerase Activation (TA) technology for non-prescription nutraceutical and cosmeceutical products and in 2007, after 5 years of development and safety testing, opened the T.A. Sciences office in New York City. In 2005 the Pattons facilitated a joint venture between Geron and the University of Science and Technology in Hong Kong. This company, TA Therapeutics (TAT), is developing Geron’s Telomerase Activation (TA) technology for therapeutic prescription drug applications. While TAT’s first drug candidate has the potential to cure a number of serious diseases, TAT hopes to file an application with the United States FDA by the end of 2008 with their first indication being a drug for rebuilding the weakened immune system of HIV/AIDS patients. Noel and Eve currently travel between Hong Kong, California, and New York. The T.A. Sciences CenterTM, located on the Upper East Side in Manhattan markets telomerase activating nutraceutical and cosmeceutical age defying products derived from Geron’s technology.

3637 37 Telomere Biology: The Emerging Paradigm Shift

In the last three decades, there has been a tremendous surge of scientific knowledge of how and why we age. Many scientists are now searching for the cure for aging and are examining technologies that could dramatically extend human healthspan and lifespan. By curing infectious diseases and improvements in sanitation, life expectancy has increased tremendously over the last century. However since the discovery of the Hayflick limit which postulated a theoretical 125-year limit on our lifespan, only one medical therapy shows potential to be able to break through this barrier. That technology is Telomere Biology.

There is a clock that ticks inside every dividing cell of our bodies. This clock is found at the tips of our chromosomes, in a region called the telomere. When human cells divide, telomeres shorten, and the length of the telomeres correlates with the age of these cells. We know that when telomeres get too short that cells either become senescent or die. This telomere clock is postulated to be the clock of aging.

The 2009 Nobel Prize in Medicine was awarded jointly to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. These three scientists have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation.

Inside every one of our cells is a gene that when turned on produces an enzyme called telomerase. Telomerase stops the telomere clock from ticking, and if it gets turned on permanently, it gives cells the ability to divide forever. Normally the gene for telomerase is turned on only in our reproductive cells; it is turned off in almost all other cells. A small-molecule compound that activates telomerase could possibly turn it back on and prevent the shortening of telomeres.

Control of telomere length is necessary if we hope to ever be able to eliminate the 125-year limit on our lifespan. And even if we don’t live that long, it is the first crucial step toward allowing us to seriously extend our ability to live a vigorous, healthy life. Telomere shortening could be the reason for ageing, not only in the individual cells but also in the organism as a whole. These discoveries have added a new dimension to our understanding of the cell, shed light on disease mechanisms, and stimulated the development of potential new therapies. (Nobel Prize Committee Press Release)

The first product to emerge from this new science is TA-65®, a single small molecule derived from the Chinese herb astragalus. In laboratory studies using human cell lines including fibroblast cells which normally do not express any telomerase, TA-65® was shown to unequivocally lengthen telomeres. TA-65® is the first and only commercially available telomerase activator that is safe for human consumption.

Each batch of TA-65® starts with 3 tons of astragalus root grown in a specific region of Inner Mongolia. Through a closely guarded proprietary process, a single molecule (TA-65®) is separated out from over 2,000 other molecules and purified to a drug-like quality. There are no other similar products available on the market.

Currently, TA-65 is the only scientifically-proven Telomerase Activator in the world available to the public. The molecule was discovered in 2000 by leading biotech company, the Geron Corporation in Menlo Park, California, and was exclusively licensed to TA Sciences in 2002.

TA-65 has been proven to activate telomerase by two independent research laboratories. Geron Chief Researcher Calvin Harley demonstrated that TA-65 induced Telomerase Activity transiently in neonatal keratinocytes. Bill Andrews and his lab at Sierra Sciences showed telomerase transiently activated by TA-65 in fetal lung fibroblasts. Most scientists who have worked with TA-65 are taking it.

These findings establish conclusively that TA-65 transiently activates telomerase. It is widely accepted in the scientific community that the only way to lengthen telomeres is through the activation of telomerase. It is also widely accepted that individuals with long telomeres are healthier and live longer.

3839 39 TA-65’s ability to activate telomerase and increase telomere length in humans has led to the following:

* Lengthening of the Shortest Telomeres. (These are the ones that really matter; it only takes one short telomere out of the 92 in every cell to send a cell into crisis.) * Improved Immune system: In particular, the % and absolute number of senescent CD8+/28- cells has significantly decreased. This is a reversal of what normally happens with age. * Improved bone density * Improved cardiovascular and hormonal biomarkers that normally show decline with age. * There are also anecdotal results, such as a decrease in presbyopia, more energy and improved athletic performance, but these effects are not universal and vary among individua

Human trial results substantiating these claims are to be published very soon in a peer-reviewed scientific journal . Short Telomeres have been associated with maladies in these tissues:

* Immune cells memory and nave * Heart cardiomyocytes * Hematopoietic stem cells * Lung alveolar cells * Skin dermis, epidermis, vasculature * Vascular intima (endothelium) * Osteoblasts, MSCs * Liver hepatocytes * Retinal pigmented tissue of eye * Chondrocytes * Skeletal muscle * Kidney cortex * Neurons

The Safety and Efficacy Record for TA-65 is powerful.

* 5 years of development and safety testing before the introduction of TA-65 * There are currently hundreds of clients taking TA-65, some for as long as 3 years * Not a single adverse reaction reported by our licensed physicians * Not a single diagnosis of new cancer * Not a single report of increased cancer load for clients who already had cancer * Not a single diagnosis of new cardiovascular disease

CONCLUSIONS

* There is a growing body of evidence associating most age-related maladies with short telomeres.

* This same body of evidence also clearly establishes that people with long telomeres age healthier and look younger

* As we age our telomeres shorten.

* Exercising and healthy habits over an extended period of time can slow the attrition of telomeres, but telomere length continually declines as we age.

* People who have not led a healthy lifestyle have accelerated the decline of their telomere lengths, and most likely will suffer premature aging and associated maladies.

* There is only one way to intervene scientifically to stop telomere shortening, and that is by activating telomerase. And, there is only one proven telomerase activator today.

3839 39 Dr Michael Perring Dr Perring read medicine at Cambridge, and St. Bartholomew’s Hospital, London. As a post-graduate at Capetown University he gained wide experience of general medicine and graduating as a Fellow of the South African College of Physicians in 1970. Vacationing as a Medical Officer in the Ciskei he made working trips to Biafra and Ethiopia as well as studying in North America.

Following his return to the UK Dr Perring worked as a Psychiatrist obtaining a Diploma in Psychological Medicine in 1973. He was a Lecturer in Sexual Medicine at Southampton University between 1970-1980. At Charing Cross Hospital he worked with Transgender patients and took a Diploma in Humanistic Psychotherapy in 1986.

From 1993 onwards Dr Perring has developed an innovative clinic, ‘Optimal Health’, focusing on the preventive aspects of healthy ageing. His caring and considered approach to health is based on wide and varied experience and the conviction that preventive disciplines are the key to an extended active life-span. He is a certified member of the American Academy of Anti-Aging Medicine, is registered as a practising psychotherapist and is accredited by the British Association of Sexual and Marital Therapists of which he is a founder member. He is a Council member of the Independent Doctors Forum and Chair of its Regulations Committee. He is Chair to Council of The Scientific Exploration Society, a Charity supporting conservation and promotion of youth in science.

Maintaining sexual function in later life

4041 41 Dr Walter Pierpaoli Born in Milano, graduates in Medicine at the University of Milano in 1960. Works as assistant and researcher at the Institute of General Pathology and obtains a PhD in Immunology. From 1963 until 1969 occupies the position of Laboratory Director at the Center of Cellular Pathology of the Italian National Research Council in Milano. Moves to Switzerland in 1969 as Head of Neuroimmunology Laboratory at the Swiss Institute of Medical Research in Davos-Platz, where he stays until 1977. Director of the NeuroImmuno Modulation (NIM) Laboratory at the University of Zurich until 1980. In 1980 he establishes his own Research Laboratory and Institute for Integrative Biomedical Research and the INTERBION Foundation for Basic Biomedical Research in Zurich. In 1988 the Institute and the Foundation are moved to Ticino, South Switzerland,. He is now Director of the “Jean Choay Institute for Neuroimmunomodulation” in Riva San Vitale, Switzerland. His scientific and clinical activity estends from basic research to clinical studies of new anti-aging interventions and therapies, and a totally new transplantation method based on a discovery and granted patents. He is author of over 130 publications on refereed scientific journals and organizer of the “Stromboli Conferences onAging and Cancer” in 1987, 1990, 1993 and 2005. He has also published popular books such as the “Melatonin Miracle”, translated into 15 languages and a New York Times bestseller (1995).

Aging-Reversing Properties of Thyrotropin Releasing Hormone (TRH)

Work in our laboratory has shown the remarkable and varied effects of TRH in the rapid reversal of aging-related changes and alterations in old rodents. It was also demonstrated that these restoring effects of TRH were not exerted via the thyroid gland, with the obvious increase of synthesis or secretion of thyroid hormones, but depended on a newly found and rather unexpected direct activity of TRH. We suggested that the tripeptide TRH, thanks to its ubiquitous localization in nature and its high concentration in key tissues such as the pineal gland, the pancreatic insulin-producing beta cells and the anterior hypothalamic area, represents a vehicle for most fundamental energy-regulating and hormone-synchronizing activities. In fact, the restoring effects of TRH could be seen in all models used, such as aging, immunodeficient animals, virus-infected and stressed mice, hypothalamus lesioned mice and in particular in old animals with typical adiposity and progressive decay of neuroendocrine, immune and hormonal functions. TRH associated to melatonin normalizes lipid metabolism and prolongs longevity in aging mice. All this previous work prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. In addition, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations. Remarkably, 4-month oral treatment with TRH maintains testes function in aging mice. As hinted by the significant increase of testes weight, TRH taken from the drinking water produces a maintenance and/or reconstitution of testes structure and function as shown by active proliferation and formation of mature spermatogonia and intensive spermatogenesis in the follicles. Apparently TRH greatly enhances the final maturation process of

4041 41 spermatogonia to spermatozoa. 4-month oral treatment with TRH protects the kidneys from amylod and hyalin infiltration of both tubuli and glomeruli, which is typical of aging mice. In fact, massive deposits of amyloid and hyalin material are clearly infiltrating the shrunken glomeruli of untreated mice with loss of filtration capacity, while hardly present in TRH-treated mice. Massive hyalin degeneration can also be observed in the tubular vessels of the untreated control mice. The extensive and repeated experiments with parenteral and oral administration of TRH show a most remarkable aging-delaying and apparently even aging-reversing effects of the neuropeptide TRH. Again, similarly to melatonin, we are confronted with an anti- aging agent with a broad spectrum of activities which must be necessarily linked to a most fundamental role in the regulation of metabolic and hormonal functions. Pierpaoli, W. and Yi, C.X. The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin releasing hormone (TRH). J. Neuroimmunol. 27: 99-109, 1990. Pierpaoli, W., Bulian D., Bulian G., and Kistler, G. Thyrotropin releasing hormone (THR) accelerates and enhances the aging-postponing effects of melatonin. J. Anti-Aging Med 2: 343-348,1999.

4243 43 Prof Dan Z Reinstein Professor Dan Reinstein has been using very high-frequency ultrasound with digital signal processing for research in refractive surgery for over 15 years and has published extensively in the fields of corneal and anterior segment biometry, the prevention of ectasia by mathematical modelling, sizing of phakic intraocular lenses and the early detection of keratoconus. Professor Reinstein graduated in medicine from Cambridge University Medical School, England, did his ophthalmology residency training at the Mount Sinai School of Medicine, NY, and fellowships in ultrasound bioengineering at the Weill Medical College of Cornell University, and cornea and refractive surgery at the University of British Columbia, Vancouver. He was made full professor of ophthalmology at the University of Paris in 1999. Professor Reinstein relocated to London in 2001, in order to work closely with engineers at Carl Zeiss Meditec, who recruited him as the lead clinical consultant for their new excimer laser, the MEL80. In 2002, he established the London Vision Clinic, where he continues as medical director. Professor Reinstein has developed advanced excimer applications including biomechanically based ablation profiles using non-linear aspherics for treating very high myopia with very low induction of aberrations, and very low tissue consumption, and has further developed these to enable presbyopic LASIK based on increasing the depth of field of the cornea. Both these applications have been adopted by Carl Zeiss Meditec for product releases. Concurrently with his medical career Professor Reinstein has continued his passion for jazz and the saxophone for over 35 years including two years of study on a performance scholarship at the Berkley College of Music, Boston, USA; he continues to play at one of London’s top Jazz venues The 606 Club in Chelsea on a regular basis with his own quartet. Professor Reinstein lives in central London with his Austrian wife Ursula, herself a veterinary surgeon, and their three young children, Julia, Maxwell and Oscar.

Setting the clock back on ageing eyes: treating presbyopia by laser eye surgery

Presbyopia or ageing-eyes is a change that affects all human beings. Sometime during the 40’s we lose the ability to zoom our focus from distance to near. Initially we start holding things further away to read, until our arms are no longer long enough. We describe novel approach to correcting presbyopia using the most advanced excimer laser technology (Carl Zeiss Meditec MEL80) in a ten minute pain-free procedure that recovers in most patients within a few hours. The MEL80 is commonly used for correction of myopia, hyperopia and astigmatism which it does by reshaping the corneal surface to change the focusing power of the eye from a point to infinity. Using the MEL80, presbyopia is treated by a procedure called Laser Blended Vision. In Laser Blended Vision the optics of the eye are altered so that rather than just focusing on a point, the depth-of-focus of the eye is expanded akin to looking at a photograph with both the foreground and the background in focus. In our studies carried out at the London Vision Clinic, 365 patients with either pure presbyopia (perfect distance vision) or presbyopia combined with myopia up to -8.50 D, hyperopia up to +5.75 D with astigmatism up to 3.00 D were treated. Mean follow-up was 12.4 months. Of all patients, 96% were able to achieve 20/20 distance vision and 98% could see 20/25. Ninety-nine percent of patients could read newsprint or better without glasses. Binocularly, 96% of patients could read newsprint or better while enjoying 20/20 distance vision simultaneously. No eye lost 2 or more lines of corrected distance visual acuity (CDVA), while 37% gained lines of CDVA. Laser Blended Vision offers a highly effective and safe treatment for the management of presbyopia.

4243 43 Prof Giovanni Scapagnini Assistant Professor, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy Assistant Professor, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville (MD), USA Visiting Professor, Institute of Human Virology, University of Maryland, Baltimore (MD), USA

Professor Scapagnini attended the University of Catania School of Medicine and Surgery in Catania, Italy and graduated in 1992 with a medical degree. He continued his education by obtaining a Ph.D. in Neurobiology also from the University of Catania in 2000. Since completing his education, Dr. Scapagnini has conducted research with the Institute of Pharmacology School of Medicine associated with the University of Catania and has worked as a Visiting Scientist with Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK in 1999, and with Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institute of Health in Bethesda, MD, USA in 2000. Dr. Scapagnini currently holds two academic positions as Assistant Professor with the Institute of Neurological Sciences, Italian National Research Council and with Blanchette Rockefeller Neurosciences Institute, West Virginia University. He has recently obtained a visiting professorship with the Institute of Human Virology, University of Maryland, where he is in charge of a research project on HIV dementia. He is also the scientific director of the “Research & Progress” foundation, founded by Dr Robert C. Gallo. He is author of 35 indexed scientific papers and several book chapters. His fields of research regard gene expression profiles of cellular stress response and biology and molecular mechanisms of brain aging and nerurodegenerative disorders. In particular he has studied the anti-aging activities of several nutraceuticals present in the Mediterranean diet.

Pre-conference Seminar - Digestion & Absorption - Beyond Nutrition: A journey into the gut microcosm

In recent years there has been a growing interest, supported by a large number of experimental and epidemiological studies outlining the beneficial effects of some commonly used food derived products capable of preventing various age-related pathologic conditions, which range from cancer to neurodegenerative diseases.

Besides the importance of nutrients and active compounds contained in food, the workshop/ seminar will focus on the relevance of the organs where digestion and absorption of nutrients occur. Because the food we consume creates the intestinal micro-environment this in turn has a fundamental influence on the pathophysiology of many diseases.

The contents of the gut are an ‘inner’ world that is ‘outside’ the cellular body. Its surface is a frontier with an area 100 meters square and a thickness of one cell .Gut flora is an organ which contains more microbial cells than the cellular body has mammalian cells (100 trillion). In this context eukaryotes and prokaryotes have developed mutually beneficial relationships over a millennia of evolutionary adaptation. Similarly bacteria in our gut relies on our diet and the protected environment of our bodies just as our health depends on by- products of microbial metabolism. The normal intestinal microflora constitutes a huge chemical factory that alters our food and our gastrointestinal secretions. The benefit from their activity is multiplex and translates into

4445 45 * increased energy for the gut epithelial cells * a balanced absorption of salt and water * nitrogen recycling * the breakdown of complex lipids and cholesterol * detoxification of waste compounds

The gut is a sensory organ. The mechanism by which the gut senses and responds to nutrients involves the ‘interplay’ of multiple complex pathways.

The gut is a neuro -endocrine organ. Every neurotransmitter found in the brain is also found here. The gut has a brain of its own, an intact and independent nervous system.

The gut is the largest organ of immune function in the body; 70% of our lymphocytes live here. In addition to regulating digestion and absorption the pathways stimulated by molecules in the gut lumen mediate gastric motility, food intake and satiety.

Finally we will explore how foods can be designed to modulate digestion and to promote health by changing the physical properties of digesta.

4445 45 Dr Daniel Sister Graduated from the Paris Medical School. Member of: General Medical Council (UK), Conseil de l’Ordre des Medecins (Fr), British Association of Cosmetic Doctors., New York Academy of Sciences., Royal Society of Medicine (Fellow)

Graduated from the Paris Medical School in 1974 . General Medical Special Interest in:

* Homeopathy, Phytotherapy. * Anti Aging, Hormones. * Non Surgical Cosmetic Procedure

Member of:

* General Medical Council (UK) * Conseil de l’Ordre des Medecins (Fr) * British Association of Cosmetic Doctors. * New York Academy of Sciences. * Royal Society of Medicine (Fellow)

Previous Membership :

* American College of Nutrition. * American Society for Bariatric Physicians. * Vice President Complementary Medicine Association. * American Academy for Anti Aging Medecine.

Innovative, Safe and Efficient:

* First to introduce Laser/Elos technology in the U.K. * First to introduce Carboxytherapy in the UK * First to introduce the VIPeel in the \UK * First to introduce the M.E.L.T. therapy in the UK * First to introduce the S3/PRP- Skin therapy in the U

Activities: Private practice in Paris since 1974 (Internal medicine, Nutrition)

Nutritionist, private practice in Los Angeles for 7 years Practice in Dublin, Belfast, Cork (Ireland) for a year Private practice in London since 1997 (Nutrition, Anti Ageing) Author of 6 books: From Fat to Fit (USA) Throw your scale away (USA) Menopause, maigrir sans faim (France) Comment dire NON à la cellulite et à l’obésité (Fr) About Beauty, Nutrition, and Anti Ageing La Medecine Anti Ageing Next to come: Transition Time Health (natural and bio identical hormones) Guest in various TV shows in France, UK, Germany, USA, Israel.

4647 47 Guest speaker at the MEDEC (Paris), 3rd Anti Ageing Conference in Monte Carlo, FACE Conference (London), Cosmeeting (Paris) Collaboration with different woman magazines in France, UK, USA. Noted by W, Harper & Queens, Tattler, Vogue, Woman’s journal, Zest … Previous Medical Consultant in France: United Airlines, Philippine Airlines, Gulf Air HealthTech Institute was founded and incorporated in the USA in November 1993 by Dr. D.L. SISTER. Since then, it has been active in USA, Canada, France, England, Saudi Arabia, and United Emirates. The interests of the company are all related to Health, Beauty, Cosmetics, Natural Products and New technologies. Either by creating, developing and marketing its own products: Ekilose, NutriLife Pro, Rejuvital…. Or by helping other companies to develop and market their specific products in different countries: USA: Food Sciences Corp., Diet Line Canada: Groupe Roy, JCLE Holdings France: Laboratoires Michel Iderne, Lysedia Belgium: Hedephar, Universal Pharma

Platelet Rich Plasma Therapies - Self Stimulated Serum - S3

Platelet Rich Plasma Platelets are small but powerful. They contain a variety of growth factors such as TGFB, VEGF, PDGF. They are small molecules also known as cytokines that Interact with the local cells and even send signals that Imitate a variety of important healing events. It is used for Dentistry = receding gums, implants Sport Medicine = Tennis Elbow etc. Veterinary, Hair losses and skin rejuvenation.

4647 47 Mr Richard Stead CEO/ Molecular Design Director, KiB Ltd

The relationship between an inefficient immune system and ageing

A significant question around aging is the role played by the immune system in causing us to age. Or is this the wrong way to approach the subject? Should we consider the effect that our aging process has on the efficacy and energy levels in the immune system? On a second level, there is no question now that infections are once again becoming major causes of illness and death. They adversely affect the overall functions of our bodies in ways known to accelerate ageing; so, theoretically, the right antibiotics, correctly used, should help keep us young. However, synthetic antibiotics are not only non-specific but they are also becoming increasingly ineffective due to increasing problems of resistance. Many also have intrinsic toxicity for humans. Therefore, would a “revolutionary new” molecule that outshines antibiotics offer a route to anti-aging?

4849 49 Prof Dr Bernard Weber A medical doctor and CEO of Laboratoires Réunis, a private medical laboratory based in Luxembourg, Europe. Laboratoires Réunis is a national leader in the field of predictive genetics and molecular diagnosis of infectious diseases and is ISO 15189 accredited since 2006. In the last five years Dr Weber and his team have developed and validated a unique panel of phenotypic and genotypic markers which constitute a very important tool for the integrative approach of multifactorial and environment linked diseases.

Genetic Analysis of Different SNPs as Potential Biomarkers in Colorectal Cancer

Genetic analysis of different SNPs (single nucleotide polymorphisms) as potential prognostic biomarkers in CRC (colorectal cancer) – a pilot study -

Laboratoires Réunis, Junglinster, Luxembourg; 2Laboratoire de Recherche sur le Cancer et les Maladies du Sang, Luxembourg

Colorectal cancer (CRC) occurs either in the colon or rectum. It is the third most common cancer and the second leading cause of cancer-related death in Western Europe. The average lifetime risk of developing CRC is about 5%. Any factor leading to increased cell division in the large intestine can potentially increase the probability of developing CRC. Environmental factors such as a diet that is poor in vegetables and rich in fat may promote cell growth. Additionally cigarette smoke, excessive alcohol consumption and inflammatory bowel disorders such as Crohn’s disease and ulcerative colitis are known to cause overgrowth of colon cells. The majority of CRCs are sporadic cases whereas about 25% of the cases have an inherited compound. Mutations in the genes MSH2 and MLH1 account for only one fifth of the inherited cases of CRC. The rest of the individual colorectal cancer risk is probably due to common genetic variants that, individually, do not contribute much to an increased risk of CRC. However the presence of many variants of these SNPs can contribute to the development of the disease. In this case, the risk can be largely reduced by changing the lifestyle.

In the present study, SNPs related to cell gowth and divison were analysed in 100 patients withan advanced CRC. The carcinomas had a histological staining equal or greater than pT1 and were thus belonging to the adenoma-carcinoma or to the carcinoma stage. The control group consisted of 100 patient not carrying a CRC. Genotyping was performed by melting curve analysis on DNA isolated from whole blood-samples.

The analysed SNPs were: p53 (rs1042522), MDM2 (rs2279744), TGFBR1 (rs334348, rs334349, rs1590), TGFBR4 (rs7871490), SMAD7 (rs4464148, rs12953717, rs493927), PROC3 (rs6983267), FLJ (rs3802842), CHR9 (rs719725) and CHR8 (rs7014346).

Our results show that especially polymorphisms related to TGFBR and SMAD7 seem to be promising CRC predispostion markers. Further studies, which focus on sequencing of the complete genes, will elucidate which role spontaneous mutations as well as known and newly discovered polymorphisms play in the development of CRC.

4849 49 AACL 2010 Exhibitors

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London’s Premier Anti-Ageing Clinic, HB Health, is the proud sponsor and organiser of the 1st, 2nd, 3rd, 4th,5th, 6th and 7th Anti Ageing Conference London (AACL).

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Anti-Aging Training The American Academy of Anti-Aging Medicine (A4M) offers physicians and health professionals the opportunity to get fully trained and certified in the fields of Anti-Aging, Regenerative and Functional Medicine.

The Fellowship program is a postgraduate educational and professional program comprising of 12 lecture modules, webcasts and professor support. Since June 2010, Modules I-IV are now available online in order to offer medical professionals more flexibility.

The Board Certification enables medical practitioners to earn recognition of their expertise in this new field of medicine. The certification process is based on two examinations, held at various examination centres around Europe, USA, and Dubai.

In 2010, the A4M also launched an applied clinical training in partnership with the ISMERIAN Anti-Aging Institute in Treviso, Italy in order to offer physicians the opportunity to transform their theoretical knowledge into clinical skills.

Anti-Aging Medicine is now practiced by thousands of medical professionals around the world in private medical offices, as well as at some of the most prestigious teaching hospitals and clinics.

Over the last 10 years, the American Academy of Anti-Aging Medicine (A4M) has stood as the only International Institution providing comprehensive and hands-on clinical training programmes and certifications in the area of preventive, anti-aging, regenerative and functional medicine.

Whether you are a young physician looking to make anti-aging medicine your specialty, or a more experienced physician looking to retrain and update your knowledge in the newest areas of medicine, or an ambitious practitioner looking to set-up an anti-aging clinic equipped with the right credentials, our programmes will help you achieve your goals and will ensure that you are ready to provide efficient and safe anti-aging therapies.

Clarisonic is the sonic technology proven to gently yet effectively loosen dirt and oil to clear your pores. The Clarisonic Cleansing System uses a patented sonic frequency of more than 300 movements per second to clean, soften and smooth your skin. In just 60 seconds a day, the Clarisonic micro-massage action cleans more than twice as effectively as manual cleansing.

The originator of the Sonicare® sonic toothbrush is now directing a new company and team of specialists, and this time has created a breakthrough in skin care technology: the Clarisonic® Skin Cleansing System: a patented sonic technology proven to be instrumental in improving facial cleansing and reducing appearance of pores, fine line and wrinkles.

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Clarisonic® is a professional-calibre sonic skincare cleansing brush which uses a patented sonic frequency of more than 300 movements per second and works with the skin’s natural elasticity to gently cleanse the skin twice as effectively as manual cleansing. It also reduces oily areas, dry skin patches and blemishes.

Clarisonic is therefore recommended by dermatologists for daily cleansing of skin – even the sensitive skin of people with rosacea, acne or seborrhea.

Clarisonic is also waterproof and can be used in the bathroom and shower and a built in one minute timer means that Clarisonic beeps to indicate when it is time to clean the next area of the face - so no additional time is added to the beauty ritual - making it as easy to use as a powered toothbrush and just as quick.

More information about Clarisonic: Please visit www.clarisonic.com/uk or telephone 0800 988 4864

International Antiaging Systems IAS supplies the latest commercially available nutrients, hormones and medicines and we are dedicated to slowing, reversing and preventing ageing. With more than 15-years of experience, come and talk to us about the latest international breakthroughs and learn how to improve your optimal health span. IAS Group, IAS House PO Box 6, Sark, GY9 0SB UK Tel UK: 0208 123 2106 USA: 415 992 5563 Fax UK: 0208 181 6106 USA: 415 366 1503 E-mail: [email protected] Website: www.antiaging-systems.com www.internationalantiagingsystems.com

Path Medical Of course it’s impossible to refute the fact that in every living being, the head is attached to the body. But modern medicine seems to constantly forget this! From treating patients like cars in a Ford assembly line, with each medical specialist focusing only on one part of the body, to neglecting the true causes and effects of illness, the brain’s master role in our physiology is repeatedly overlooked.

At PATH Medical, the brain guides us. We know that every illness ages the brain, and that imbalances in the brain can also lead to illness elsewhere in the body. We know that virtually every disease is diagnosable even before signs and symptoms appear,

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and that in order to deliver care that will restore and preserve total health, we must have early diagnosis of chronic disease.

We accomplish this by using state-of-the-art technology, including a head-to-toe ultrasound-based examination, and a computerized EEG to ascertain the functioning of the brain.

We interpret the results and then can begin the process of reversing disease, which is often accelerated aging, and develop a plan of action uniquely tailored to each patient’s biochemistry and needs.

Through lifestyle recommendations, proper nutrition through diet and supplementation, bioidentical hormone replacement therapy, and psychotropic medications as a last resort, we guide the patient toward a healthier future.

Receptura Pharmaproduktion GmbH The Individual Anti-Aging Therapy - Prescribing Hormones Easily Compounded Bioidentical Hormones

We are specialized in compounding individually formulated bio identical hormone products for BHRT according to physician’s prescription and the patient’s individual needs.

After more than ten years of experience we are proud to provide not only highest quality products but also an excellent service to our customers.

Our products: • Compounding of individual combined products • Manufacturing in accordance to the pharmaceutical European GMP Guidelines • Highest pharmaceutical quality standard • Human Identical Hormones • Modern quality testing (e.g. HPLC) guarantee the usage of only finest ingredients and excipients • Highest Bioavailability – No first pass effect • Only vegetarian cellulose capsules are used • Very well tolerated, resulting in high patient compliance

Highest Bioavailability is achieved with special developed carrier systems • WIP BASE ® cream, liposomal cream and gel for topical and vaginal application • Lipophilic, oil based system for Capsules • Lozenges for buccal application Service: • World Wide Shipping • Spoken languages German, English, French, Spanish, Italian

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• Individual Customer Care

Hormone cosmetics • Maintaining healthy skin • Looking as young as you feel • Can be composed individual according to your patients needs • Synergistically combinations to nourish and protect skin and hair against aging

Ingredients used e.g. Bio Identical Hormones Thyroid-Hormones Phytohormones Vitamins Antioxidants Plant Extracts and others A special subject of Receptura Anesthetic Gels for local anesthesia especially for the laser therapy with Lipothene 133™ base

Formulation examples: • Lidocaine base 30 %, Lipothene 133™ • Lidocaine base 23 %, Tetracaine 7 % (Tetracaine base 3,5 %/Tetracaine HCL 3,5 %), Lipothene 133™ Nutritional Supplements To ensure a complete and comprehensive service our affiliated distribution company FORMULA offers a wide range of nutritional supplements. [email protected]

RegenLab RegenLab develops patented devices and protocols for the stimulation of our own stem cells.

Regen Lab’s cell therapies are focused on isolation and application of patient’s own cells from blood, fat (adipocytes) and bone marrow (stem cells).

The treatments are inherently efficient and point of care.

Regenlab is an independent Swiss biotech company based in Le Mont-sur-Lausanne, Switzerland and operating in the national and international healthcare market.

Sun Chlorella Sun Chlorella for healthy living all over the World

Sun Chlorella provides the highest quality health food in Japan and all over the world from our health network, based at Sun Chlorella Japan.

A healthy diet is fundamental for building your body. It’s hard to avoid stress and to have balanced nutrition in current society. Health is an irreplaceable asset regardless of sex, age

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or generation. Try Sun Chlorella for your health management and nutritional support.

Now delivering the same healthy product that has been so popular in other countries to customers in the UK, providing quality and value that is sure to be appreciated.

Our products offer benefits that can help with health issues - just browse our online store for our full range. Health foods, benefits for the World through Sun Chlorella

At Sun Chlorella, we’re proud to belong to a global network, and we have offices all over the world with an aim to provide the very best service to you.

Our fundamental belief is that in the modern world there are no borders in a desire for good health. Our products are internationally popular and loved in many countries. Call us today for your needs and much, much more

At SunChlorella.co.uk we pride ourselves on our customer service and all orders will be delivered free of charge. You can order online, freephone 0800 008 6166 (Mon-Fri 0830- 1700), fax on 020 7025 6728, email [email protected] or by post. (If you live outside the UK, please contact us for further information.)

TA Sciences Welcome to T.A. Sciences. We are the first company in the world to offer our clients the ability to fight aging through the emerging science of telomere biology.

Telomeres are DNA repeats located at the ends of all chromosomes. They serve as end- caps that protect our genes. Each time a cell divides, the telomeres grow shorter and shorter. Once telomeres become too short, a cell can no longer divide, and it eventually dies.

However, there is a natural enzyme called telomerase which can help maintain telomere length. In 2001, California bio-tech company Geron, made a paradigm-shifting discovery. They discovered TA-65®, a single molecule that activates telomerase. In 2002 T.A. Sciences licensed exclusive rights to TA-65® from the famed bio-tech company Geron.

Telomerase Activation with TA-65® Telomerase Activation works on all of cells in your body and can improve not only longevity but quality of life. A double-blind, placebo controlled study of TA-65® showed improvements in:

* immune system function * vision * sexual function * energy levels

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* skin elasticity * and more.

Learn more about the new world of telomerase activation as a method to intervene in the aging process. Understand how taking TA-65 as part of the year-long Patton Protocol may improve your health and vitality. Find out your real biological age by testing your biomarkers of aging and measuring the length of your telomeres.

TV Rejuvenation TV Rejuvenation philosophy is a drug-free therapy for the human body to keep it in optimum condition and aims at Removing, Replacing and Regulating in harmony with biological rhythms.

Dr. Tamara Voronina creates a unique combination of conventional and traditional medicine which is a powerful regulator of the hormone, nervous and immune systems. The combined techniques include Intermittent Hypoxia Training (IHT), Korean (Su Jok) and Chinese acupuncture, dieting, supplementary vitamins and homeopathy. The therapy can show within a few days significant, positive and definite results in the treatment of obesity, diabetes, thyroid disorders as well fatigue, stress and depression .

She has conducted biochemistry research about different nutrition regimes, including fasting, and has published several scientific articles and a review about her experience with IHT during the last 13 years in the UK. Her last publications were 1. Prokopov A, Voronina T. Intermittent Hypoxic Therapy / Training (IHT): The aetiologic and pathogenetic anti-aging treatment. Rejuvenation Research. 2007. Vol.10. S1. p. 45. 2. Prokopov, A., Voronina, T. Engineered natural longevity - enhancing interventions. In: Handbook on Longevity: Genetics, Diet and Disease. Editors: Jennifer V. Bentely and Mary Ann Keller. Nova Science Publishers. Hauppauge NY. 2009. ISBN: 978-1-60741-075-1

Rejuvenation Cruises Rejuvenation Cruises offers a unique opportunity for passengers on luxury cruises to access a combination of sea air, high altitude ‘mountain air’ and other natural therapies in order to improve health and longevity.

The main concept of rejuvenation is detoxification, restoration, maintenance and self – regulation.

TV Rejuvenation and Rejuvenation Cruises Dr. Tamara Voronina Tel: +44 (0) 207 935 8416 E-mail: [email protected] Web: http//tvrejuvenation.com

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Ysonut Facing the nutritional challenges of 21st Century

Ysonut Laboratories was born in France more than 15 years ago with the intention of generating solutions for the nutritional disorders of our time as well as their associated health risks such as obesity, recently announced by WHO as a world epidemic.

An innovative and effective solution: Rythmonutrition®

In an attempt to tackle the above challenge, Ysonut Laboratories has developed a new approach to nutrition based on the study of biological rhythms – hence, Rythmonutrition® -, which guarantees the reliability and efficacy of our products, namely:

• PROTÉIFINE®: a wide range of protein products for efficient weight loss exclusively under medical supervision. For the whole duration of the Protéifine diet the Dynovance and Sérovance products give the extra benefit of mood and satiety control.

• INOVANCE®: a wide range of high quality nutritional supplements to counteract the deficiencies in micronutrients – vitamins, minerals, trace elements, etc. – that are very common in modern lifestyles.

A front line team at the edge of research

Behind the products and concepts created by Ysonut Laboratories lies our scientific committee: a body consisting of doctors specialized in nutritional medicine whose mission is to devise, develop and validate the laboratory’s activities in collaboration with a wide network of international authorities in nutritional sciences.

An international leader with a promising future

Ever since its beginnings, Ysonut Laboratories has come forward as a reference in the field of medical dietetics for health professionals.

Our success stems from a strict adherence to our principles of rigour, honesty and excellence throughout all our activities, research, products and services.

Our unfailing commitment to every party we liaise with - suppliers, collaborators, clients etc, over the years has earned us trust and confidence. The resulting long term steady growth has been systematically reinvested in the company’s continuing development at all levels.

5859 59 AACL 2010 Sponsors and Supporters

5859 59 Acknowledgements

AACL 2010 would like to thank the following for their valuable contribution and support Heather Bird Tchenguiz President of AACL 2010 Maria Somers Conference Director & Organiser HBHealth Conference Sponsorship Luigi Cuozzo Guidance, support & Moderator Phil Micans Guidance, support & Moderator Professor Syed Haq Guidance, support & Moderator Dr Masud Haq Moderator Dr Nyjon Eccles Moderator Dr Wendy Denning Moderator All the Speakers For giving their time to AACL 2010 Alice Leashkevich PA to Maria Somers Wayne Harding USA Web Management/Graphic Design/Photography Susan Harding Secretariat Daniel Zargel IT Continuity Sun Chlorella Corporation Conference & Gala bags TASciences Gala Cocktail Party R20 staff Royal College of Organists Staff

Finally to all the Exhibitors and Delegates who have supported AACL 2010

6061 61 Contacts

It was a privilege to have you attend the Anti-Ageing Conference in London (AACL). Should you require any information regarding this year’s or next year’s Anti Ageing Conference in London (AACL), or details of upcoming events please contact us: 8th Anti Aging Conference London 23rd/24th/25th September 2011

Anti Ageing Conference London (AACL) 38 Regent on the River William Morris Way London SW6 2 UT United Kingdom

Tel: +44 (0)20 7973173478 Fax: +44 (0)20 7491 0410 Email: [email protected] Or visit our website: www.antiageingconference.com