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Chemistry and Pharmacology of Kinkéliba (Combretum
CHEMISTRY AND PHARMACOLOGY OF KINKÉLIBA (COMBRETUM MICRANTHUM), A WEST AFRICAN MEDICINAL PLANT By CARA RENAE WELCH A Dissertation submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey in partial fulfillment of the requirements for the degree of Doctor of Philosophy Graduate Program in Medicinal Chemistry written under the direction of Dr. James E. Simon and approved by ______________________________ ______________________________ ______________________________ ______________________________ New Brunswick, New Jersey January, 2010 ABSTRACT OF THE DISSERTATION Chemistry and Pharmacology of Kinkéliba (Combretum micranthum), a West African Medicinal Plant by CARA RENAE WELCH Dissertation Director: James E. Simon Kinkéliba (Combretum micranthum, Fam. Combretaceae) is an undomesticated shrub species of western Africa and is one of the most popular traditional bush teas of Senegal. The herbal beverage is traditionally used for weight loss, digestion, as a diuretic and mild antibiotic, and to relieve pain. The fresh leaves are used to treat malarial fever. Leaf extracts, the most biologically active plant tissue relative to stem, bark and roots, were screened for antioxidant capacity, measuring the removal of a radical by UV/VIS spectrophotometry, anti-inflammatory activity, measuring inducible nitric oxide synthase (iNOS) in RAW 264.7 macrophage cells, and glucose-lowering activity, measuring phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in an H4IIE rat hepatoma cell line. Radical oxygen scavenging activity, or antioxidant capacity, was utilized for initially directing the fractionation; highlighted subfractions and isolated compounds were subsequently tested for anti-inflammatory and glucose-lowering activities. The ethyl acetate and n-butanol fractions of the crude leaf extract were fractionated leading to the isolation and identification of a number of polyphenolic ii compounds. -
Review on Combretaceae Family
Int. J. Pharm. Sci. Rev. Res., 58(2), September - October 2019; Article No. 04, Pages: 22-29 ISSN 0976 – 044X Review Article Review on Combretaceae Family Soniya Rahate*, Atul Hemke, Milind Umekar Department of Quality Assurance, Shrimati Kishoritai Bhoyar College of Pharmacy, Kamptee, Dist-Nagpur 441002, India. *Corresponding author’s E-mail: [email protected] Received: 06-08-2019; Revised: 22-09-2019; Accepted: 28-09-2019. ABSTRACT Combretaceae, the family of flowering plants consisting of 20 genus and 600 important species in respective genus. The two largest genera of the family are Combretum and Terminalia which contains the more no. of species. The members of the family are widely distributed in tropical and subtropical regions of the world. Most members of the trees, shrubs or lianas of the combretaceae family are widely used medicinally. The members of this family contain the different phytoconstituents of medicinal value e.g tannins, flavonoids, terpenoids and alkaloids. Most of the species of this family are used as antimicrobial, antioxidant and antifungal. The biological activities of the some members of this family yet not found. Apart from the medicinal value many members of the Combretaceae are of culinary and ornamental value. Keywords: Combretaceae, Tannins, Flavonoid, Terminalia, Combretum. INTRODUCTION species of Combretum have edible kernels whereas Buchenavia species have edible succulent endocarps. he family combretaceae is a major group of Chemical constituents like tannins are also found in fruits, flowering plants (Angiosperms) included in the bark, leaves, roots and timber in buchenavia and order of Myrtales. Robert Brown established it in T terminalia genera. Many of the species are reputed to 1810 and its inclusion to the order is not in dispute. -
Red Data List Special Edition
Newsletter of the Southern African Botanical Diversity Network Volume 6 No. 3 ISSN 1027-4286 November 2001 Invasive Alien Plants Part 2 Southern Mozambique Expedition Living Plant Collections: Lowveld, Mozambique, Namibia REDSABONET NewsDATA Vol. 6 No. 3 November LIST 2001 SPECIAL EDITION153 c o n t e n t s Red Data List Features Special 157 Profile: Ezekeil Kwembeya ON OUR COVER: 158 Profile: Anthony Mapaura Ferraria schaeferi, a vulnerable 162 Red Data Lists in Southern Namibian near-endemic. 159 Tribute to Paseka Mafa (Photo: G. Owen-Smith) Africa: Past, Present, and Future 190 Proceedings of the GTI Cover Stories 169 Plant Red Data Books and Africa Regional Workshop the National Botanical 195 Herbarium Managers’ 162 Red Data List Special Institute Course 192 Invasive Alien Plants in 170 Mozambique RDL 199 11th SSC Workshop Southern Africa 209 Further Notes on South 196 Announcing the Southern 173 Gauteng Red Data Plant Africa’s Brachystegia Mozambique Expedition Policy spiciformis 202 Living Plant Collections: 175 Swaziland Flora Protection 212 African Botanic Gardens Mozambique Bill Congress for 2002 204 Living Plant Collections: 176 Lesotho’s State of 214 Index Herbariorum Update Namibia Environment Report 206 Living Plant Collections: 178 Marine Fishes: Are IUCN Lowveld, South Africa Red List Criteria Adequate? Book Reviews 179 Evaluating Data Deficient Taxa Against IUCN 223 Flowering Plants of the Criterion B Kalahari Dunes 180 Charcoal Production in 224 Water Plants of Namibia Malawi 225 Trees and Shrubs of the 183 Threatened -
Phylogenetic Study of African Combretaceae R. Br. Based on /.../ A
BALTIC FORESTRY PHYLOGENETIC STUDY OF AFRICAN COMBRETACEAE R. BR. BASED ON /.../ A. O. ONEFELY AND A. STANYS ARTICLES Phylogenetic Study of African Combretaceae R. Br. Based on rbcL Sequence ALFRED OSSAI ONEFELI*,1,2 AND VIDMANTAS STANYS2,3 1Department of Forest Production and Products, Faculty of Renewable Natural Resources, University of Ibadan, 200284 Ibadan, Nigeria. 2Erasmus+ Scholar, Institute of Agricultural and Food Science Vytautas Magnus University, Agricultural Aca- demy, Akademija, LT-53361 Kaunas district, Lithuania. 3Department of Orchard Plant Genetics and Biotechnology, Lithuanian Research Centre for Agriculture and Forestry, Babtai, LT-54333 Kaunas district, Lithuania. *Corresponding author: [email protected], [email protected] Phone number: +37062129627 Onefeli, A. O. and Stanys, A. 2019. Phylogenetic Study of African Combretaceae R. Br. Based on rbcL Se- quence. Baltic Forestry 25(2): 170177. Abstract Combretaceae R. Br. is an angiosperm family of high economic value. However, there is dearth of information on the phylogenetic relationship of the members of this family using ribulose biphosphate carboxylase (rbcL) gene. Previous studies with electrophoretic-based and morphological markers revealed that this family is phylogenetically complex. In the present study, 79 sequences of rbcL were used to study the phylogenetic relationship among the members of Combretaceae of African origin with a view to provide more information required for the utilization and management of this family. Multiple Sequence alignment was executed using the MUSCLE component of Molecular Evolutionary Genetics Version X Analysis (MEGA X). Transition/Transversion ratio, Consistency index, Retention Index and Composite Index were also determined. Phylogenetic trees were constructed using Maximum parsimony (MP) and Neighbor joining methods. -
Combretaceae: Phylogeny, Biogeography and DNA
COPYRIGHT AND CITATION CONSIDERATIONS FOR THIS THESIS/ DISSERTATION o Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. o NonCommercial — You may not use the material for commercial purposes. o ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. How to cite this thesis Surname, Initial(s). (2012) Title of the thesis or dissertation. PhD. (Chemistry)/ M.Sc. (Physics)/ M.A. (Philosophy)/M.Com. (Finance) etc. [Unpublished]: University of Johannesburg. Retrieved from: https://ujdigispace.uj.ac.za (Accessed: Date). Combretaceae: Phylogeny, Biogeography and DNA Barcoding by JEPHRIS GERE THESIS Submitted in fulfilment of the requirements for the degree PHILOSOPHIAE DOCTOR in BOTANY in the Faculty of Science at the University of Johannesburg December 2013 Supervisor: Prof Michelle van der Bank Co-supervisor: Dr Olivier Maurin Declaration I declare that this thesis has been composed by me and the work contained within, unless otherwise stated, is my own. _____________________ J. Gere (December 2013) Table of contents Table of contents i Abstract v Foreword vii Index to figures ix Index to tables xv Acknowledgements xviii List of abbreviations xxi Chapter 1: General introduction and objectives 1.1 General introduction 1 1.2 Vegetative morphology 2 1.2.1 Leaf morphology and anatomy 2 1.2.2. Inflorescence 3 1.2.3 Fruit morphology 4 1.3 DNA barcoding 5 1.4 Cytology 6 1.5 Fossil record 7 1.6 Distribution and habitat 7 1.7 Economic Importance 8 1.8 Taxonomic history 9 1.9 Aims and objectives of the study 11 i Table of contents Chapter 2: Molecular phylogeny of Combretaceae with implications for infrageneric classification within subtribe Terminaliinae. -
SABONET Report No 18
ii Quick Guide This book is divided into two sections: the first part provides descriptions of some common trees and shrubs of Botswana, and the second is the complete checklist. The scientific names of the families, genera, and species are arranged alphabetically. Vernacular names are also arranged alphabetically, starting with Setswana and followed by English. Setswana names are separated by a semi-colon from English names. A glossary at the end of the book defines botanical terms used in the text. Species that are listed in the Red Data List for Botswana are indicated by an ® preceding the name. The letters N, SW, and SE indicate the distribution of the species within Botswana according to the Flora zambesiaca geographical regions. Flora zambesiaca regions used in the checklist. Administrative District FZ geographical region Central District SE & N Chobe District N Ghanzi District SW Kgalagadi District SW Kgatleng District SE Kweneng District SW & SE Ngamiland District N North East District N South East District SE Southern District SW & SE N CHOBE DISTRICT NGAMILAND DISTRICT ZIMBABWE NAMIBIA NORTH EAST DISTRICT CENTRAL DISTRICT GHANZI DISTRICT KWENENG DISTRICT KGATLENG KGALAGADI DISTRICT DISTRICT SOUTHERN SOUTH EAST DISTRICT DISTRICT SOUTH AFRICA 0 Kilometres 400 i ii Trees of Botswana: names and distribution Moffat P. Setshogo & Fanie Venter iii Recommended citation format SETSHOGO, M.P. & VENTER, F. 2003. Trees of Botswana: names and distribution. Southern African Botanical Diversity Network Report No. 18. Pretoria. Produced by University of Botswana Herbarium Private Bag UB00704 Gaborone Tel: (267) 355 2602 Fax: (267) 318 5097 E-mail: [email protected] Published by Southern African Botanical Diversity Network (SABONET), c/o National Botanical Institute, Private Bag X101, 0001 Pretoria and University of Botswana Herbarium, Private Bag UB00704, Gaborone. -
Tanzania Wildlife Research Institute (Tawiri)
TANZANIA WILDLIFE RESEARCH INSTITUTE (TAWIRI) PROCEEDINGS OF THE ELEVENTH TAWIRI SCIENTIFIC CONFERENCE, 6TH – 8TH DECEMBER 2017, ARUSHA INTERNATIONAL CONFERENCE CENTER, TANZANIA 1 EDITORS Dr. Robert Fyumagwa Dr. Janemary Ntalwila Dr. Angela Mwakatobe Dr. Victor Kakengi Dr. Alex Lobora Dr. Richard Lymuya Dr. Asanterabi Lowassa Dr. Emmanuel Mmasy Dr. Emmanuel Masenga Dr. Ernest Mjingo Dr. Dennis Ikanda Mr. Pius Kavana Published by: Tanzania Wildlife Research Institute P.O.Box 661 Arusha, Tanzania Email: [email protected] Website: www.tawiri.or.tz Copyright – TAWIRI 2017 All rights reserved. No part of this publication may be reproduced in any form without permission in writing from Tanzania Wildlife Research Institute. 2 CONFERENCE THEME "People, Livestock and Climate change: Challenges for Sustainable Biodiversity Conservation” 3 MESSAGE FROM THE ORGANIZING COMMITTEE The Tanzania Wildlife Research Institute (TAWIRI) scientific conferences are biennial events. This year's gathering marks the 11th scientific conference under the Theme: "People, Livestock and Climate change: Challenges for sustainable biodiversity conservation”. The theme primarily aims at contributing to global efforts towards sustainable wildlife conservation. The platform brings together a wide range of scientists, policy markers, conservationists, NGOs representatives and Civil Society representatives from various parts of the world to present their research findings so that management of wildlife resources and natural resources can be based on sound scientific information -
Basic Assessment Report
BASIC ASSESSMENT REPORT DRAFT BASIC ASSESSMENT FOR THE PROPOSED DEVELOPMENT OF A 0.6 HECTARE CHICKEN LAYER FACILITY ON A 7.8 HECTARE FARM IN MASHAU- BODWE VILLAGE, MAKHADO DISTRICT, LIMPOPO. Prepare for WANGA POULTRY FARM (Pty) Ltd CSIR Reference Number: CSIR/02100/Implementation Unit/IR/2016/0005 January 2017 Page 1 Basic Assessment Process For the proposed development of a 0.6 hectare Chicken Layer Facility on a 7.8 hectare farm in Mashau-Bodwe Village, Makhado District, Limpopo. BASIC ASSESSMENT REPORT CSIR Reference Number: CSIR/02100/Implementation Unit/IR/2016/0005/A January 2017 Prepared for: Wanga Poultry Farm (Pty) Ltd Prepared by: CSIR 11 Jan Cilliers Street, Stellenbosch, 7600, South Africa Lead Author: Rirhandzu Marivate (Cand. Sci. Nat) Reviewer: Minnelise Levendal © CSIR 2016. All rights to the intellectual property and/or contents of this document remain vested in the CSIR. This document is issued for the sole purpose for which it is supplied. No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by means electronic, mechanical, photocopying, recording or otherwise without the express written permission of the CSIR. It may also not be lent, resold, hired out or otherwise disposed of by way of trade in any form of binding or cover than that in which it is published. Page 2 Title: Basic Assessment Report for the proposed development of a 0.6 hectare Chicken Layer Facility on a 7.8 hectare farm in Mashau-Bodwe Village, Makhado District, Limpopo. Purpose of this report: This Basic Assessment (BA) Report forms part of a series of reports and information sources that are being provided during the BA Process for the the development of a 0.6 ha Chicken Layer Facility on a 7.8 hectare farm in Mashau-Bodwe Village, Makhado District, Limpopo. -
Combretaceae) on Drug-Resistant Strains of Helicobacter Pylori
J HEALTH POPUL NUTR 2011 Oct;29(5):438-445 ©INTERNATIONAL CENTRE FOR DIARRHOEAL ISSN 1606-0997 | $ 5.00+0.20 DISEASE RESEARCH, BANGLADESH Inhibitory and Bactericidal Potential of Crude Acetone Extracts of Combretum molle (Combretaceae) on Drug-resistant Strains of Helicobacter pylori Collise Njume1, Anthony J. Afolayan2, Amidou Samie3, and Roland N. Ndip1,4 1Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology and 2Phytomedicine Research Group, Department of Botany, Faculty of Science and Agriculture, University of Fort Hare, P/Bag X1314, Alice 5700, South Africa, 3Department of Microbiology, University of Venda, Thohoyandou 0950, South Africa, and 4Department of Biochemistry and Microbiology, Faculty of Science, University of Buea, Box 63, Buea, Cameroon ABSTRACT Infection with Helicobacter pylori is strongly associated with a number of gastroduodenal pathologies. Anti- microbial resistance to commonly-used drugs has generated a considerable interest in the search for novel therapeutic compounds from medicinal plants. As an ongoing effort of this search, the susceptibility of 32 clinical strains of H. pylori and a reference strain—NCTC 11638—was evaluated against five solvent ex- tracts of Combretum molle, a plant widely used for the treatment of gastric ulcers and other stomach-related morbidities in South Africa. The extracts were screened for activity by the agar-well diffusion method, and the most active one of them was tested against the same strains by micro-broth dilution and time kill as- says. Metronidazole and amoxicillin were included in these experiments as positive control antibiotics. The solvent extracts all demonstrated anti-H. pylori activity with zone diameters of inhibition between 0 and 38 mm. -
Cardiovascular Effects of Mollic Acid Glucoside, a 1Α-Hy-Droxycycloartenoid Saponin Extractive from Combretum Molle R Br Ex G Don (Combretaceae) Leaf
128 CARDIOVASCULAR JOURNAL OF AFRICA Vol 19, No. 3, May/June 2008 Cardiovascular Topics Cardiovascular effects of mollic acid glucoside, a 1α-hy- droxycycloartenoid saponin extractive from Combretum molle R Br ex G Don (Combretaceae) leaf JOHN AO OJEWOLE Summary The Combretaceae family of plants consists of 18 known genera, The cardiovascular effects of mollic acid glucoside (MAG), the largest of which are Combretum with about 370 species, and Terminalia with about 200 species.1,2 The Combretaceae a 1α-hydroxycycloartenoid saponin extractive from Combretum molle R Br ex G Don (Combretaceae) leaf, have family is well represented in southern Africa, particularly in the 3 been investigated in some experimental animal paradigms. bushveld. More than 50 species of the family reach tree size. Plant species from the genus Combretum, and to a lesser extent, The plant extract (MAG, 5–80 µg/ml) produced concen- tration-dependent, significant (p 0.05–0.001) negative Terminalia, are most widely used for medicinal purposes in < 2 inotropic and negative chronotropic effects on guinea pig African folk medicines. The genus Combretum, the largest in isolated electrically driven left, and spontaneously beating the family Combretaceae, is represented in southern Africa by right atrial muscle preparations, respectively. MAG also about 30 species of trees or shrubs, some of which feature prom- inently in traditional African medicine.4 Combretum species are significantly reduced (p < 0.05–0.001) or abolished, in a concentration-dependent manner, the rhythmic, sponta- also widely distributed in many other parts of Africa where they 5 neous contractions of portal veins isolated from healthy, often constitute the most abundant species. -
African Continent a Likely Origin of Family Combretaceae (Myrtales)
Annual Research & Review in Biology 8(5): 1-20, 2015, Article no.ARRB.17476 ISSN: 2347-565X, NLM ID: 101632869 SCIENCEDOMAIN international www.sciencedomain.org African Continent a Likely Origin of Family Combretaceae (Myrtales). A Biogeographical View Jephris Gere 1,2*, Kowiyou Yessoufou 3, Barnabas H. Daru 4, Olivier Maurin 2 and Michelle Van Der Bank 2 1Department of Biological Sciences, Bindura University of Science Education, P Bag 1020, Bindura Zimbabwe. 2Department of Botany and Plant Biotechnology, African Centre for DNA Barcoding, University of Johannesburg, P.O.Box 524, South Africa. 3Department of Environmental Sciences, University of South Africa, Florida campus, Florida 1710, South Africa. 4Department of Plant Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa. Authors’ contributions This work was carried out in collaboration between all authors. Author JG designed the study, wrote the protocol and interpreted the data. Authors JG, OM, MVDB anchored the field study, gathered the initial data and performed preliminary data analysis. While authors JG, KY and BHD managed the literature searches and produced the initial draft. All authors read and approved the final manuscript. Article Information DOI: 10.9734/ARRB/2015/17476 Editor(s): (1) George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA. Reviewers: (1) Musharaf Khan, University of Peshawar, Pakistan. (2) Ma Nyuk Ling, University Malaysia Terengganu, Malaysia. (3) Andiara Silos Moraes de Castro e Souza, São Carlos Federal University, Brazil. Complete Peer review History: http://sciencedomain.org/review-history/11778 Received 16 th March 2015 Accepted 10 th April 2015 Original Research Article Published 9th October 2015 ABSTRACT Aim : The aim of this study was to estimate divergence ages and reconstruct ancestral areas for the clades within Combretaceae. -
Descriptive Part 145
BLUMEA 25 (1979) 141-223 Wood anatomy oftheCombretaceae G.J.C.M. van Vliet Hortus Botanicus, Plantage Middenlaan 2, Amsterdam, The Netherlands Summary The wood ofall of the Combretaceae is described in detail anatomy genera (Meiostemonexcepted) on 19 data the basis of 120 samples representing 90 species from genera. Additional from the literature are added. The structural variation of the vestured pits is described and classified. There aretwo main types, of which the distribution follows the subfamilyclassification. Consideringthe overall wood anatomy, the recognition of two subfamilies: Strephonematoideae (Strephonema only) and Combretoideae (all of its of remaining genera) can be supported. Strephonema stands out on account fibre-tracheids, type vesturing and parenchyma distribution pattern. Within Combretoideae, one group of genera (subtribe Combretinae sensuExell & Stace)stands out markedly on account of their radial vessels, a uniquefeature known in other and distinct size classes of vessel elements. The not to occur any plant group, two remaining genera, belongingto the tribe Laguncularieaeand subtribes Terminaliinae and Pteleopsidinae of tribe Combreteae show a wide overlap in wood anatomical features. The Laguncularieae differ in the ratio of vessel member to fibre length, Terminaliinae and Pteleopsidinae cannot be separated wood anatomically. Although difficult to interpret phylogenetically, arguments are brought forward to consider Strephonema ashaving the most primitive wood structure and the Combretinae to have the most derived wood. Variation in some quantitative characters such as vessel member length is shown to be at least partly correlated with ecological conditions of the taxa involved. Wood anatomical differences between lianas and discussed. the of the Combretaceae and erect species are Synoptical keys to genera to the species studied of Terminalia are given.