DOCSLIB.ORG

Sleep Disturbance in Movement Disorders

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Sleep Disturbance in Movement Disorders Movement disorders J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp-2020-325546 on 19 March 2021. Downloaded from Review Sleep disturbance in movement disorders: insights, treatments and challenges Grace A Bailey ,1 Emily K Hubbard,2 Alfonso Fasano,3,4,5 Marina AJ Tijssen ,6 Timothy Lynch,7 Kirstie N Anderson,8 Kathryn J Peall 1 ► Prepublication history ABSTRACT well established as predating motor symptom and additional material is Sleep and circadian rhythm disturbances are central onset.1 In contrast, those such as adult- onset published online only. To view please visit the journal online features of many movement disorders, exacerbating primary, idiopathic dystonia, may have poor (http:// dx. doi. org/ 10. 1136/ motor and non- motor symptoms and impairing quality sleep with evidence suggesting a link to psychi- jnnp- 2020- 325546). of life. Understanding these disturbances to sleep is atric symptom severity.2 1 clinically important and may further our understanding This review provides an overview of the Neuroscience and Mental of the underlying movement disorder. This review common sleep disorders and the evidence to Health Research Institute, Cardiff University, Cardiff, UK evaluates the current anatomical and neurochemical date for the patterns and prevalence across a 2School of Medicine, Cardiff understanding of normal sleep and the recognised spectrum of movement disorders. We discuss the University, Cardiff, UK primary sleep disorders. In addition, we undertook a 3 tools available for sleep assessment, the impact Edmond J Safra Program in systematic review of the evidence for disruption to of medication used in motor symptom manage- Parkinson’s Disease, Morton and Gloria Shulman Movement sleep across multiple movement disorders. Rapid eye ment on sleep, and how disturbed sleep can Disorders Clinic, Toronto movement sleep behaviour disorder has emerged as affect daytime motor function. Finally, we high- Western Hospital, Toronto, the most reliable prodromal biomarker for the alpha light future challenges to the field, and general Ontario, Canada 4 synucleinopathies, including Parkinson’s disease considerations in the assessment and treatment Division of Neurology, and multiple system atrophy, often preceding motor University of Toronto, Toronto, of sleep disorders in patients diagnosed with a Ontario, Canada symptom onset by several years. Abnormal sleep has movement disorder. 5Krembil Research Institute, also been described for many other movement disorders, Toronto, Ontario, Canada but further evidence is needed to determine whether copyright. 6 Department of Neurology, this is a primary or secondary phenotypic component University Medical Centre Sleep structure, anatomy and physiology Groningen, Groningen, The of the underlying condition. Medication used in the Sleep cycles approximately every 90–120 min Netherlands treatment of motor symptoms also affects sleep and between an initial non-REM (NREM) stage 7 Dublin Neurological Institute, can aggravate or cause certain sleep disorders. Within (subdivided into N1–3 stages), followed by The Mater Misericordiae the context of movement disorders, there is also some a REM/R phase with a relative muscle atonia. University Hospital, Dublin, suggestion of a shared underlying mechanism for motor Dublin, Ireland Figure 1 summarises the typical hypnogram, 8Department of Neurology, and sleep pathophysiology, with evidence implicating although with normal ageing, night awaken- Newcastle Upon Tyne Hospitals thalamic and brainstem structures and monoaminergic ings increase, N3 decreases and total sleep time NHS Foundation Trust, neurotransmission. This review highlights the need for an shortens. Newcastle Upon Tyne, UK understanding of normal and abnormal sleep within the Maintenance of the sleep/wake circuit is regu- http://jnnp.bmj.com/ movement disorder clinic, an ability to screen for specific lated by the fast- acting neurotransmitters gluta- Correspondence to causes of poor sleep and to treat sleep disturbance to Dr Kathryn J Peall, Neuroscience mate and gamma aminobutyric acid (GABA), and Mental Health Research improve quality of life. Key sleep disorders also act as while an array of excitatory neurotransmitters Institute, Cardiff University, important biomarkers and have implications in diagnosis, are thought to have a modulatory role, including Cardiff CF24 4HQ, UK; PeallKJ@ prognosis and the development of future therapies. cardiff. ac. uk hypocretin/orexin (lateral hypothalamus, LH), histamine (tuberomammillary nucleus), acetyl- Received 3 November 2020 choline (pedunculopontine (PPT) and latero- on September 26, 2021 by guest. Protected Revised 7 January 2021 dorsal tegmentum), norepinephrine (locus Accepted 1 February 2021 INTRODUCTION Published Online First 19 March Abnormal sleep and circadian rhythm disorders coeruleus), dopamine (ventral periaqueductal 2021 are seen in many patients with movement disor- grey (vPAG) matter) and serotonin (raphe ders, although they remain underdiagnosed and nuclei) (figure 2A–C). Sleep regulatory circuits are a significant unmet need in clinical care. are widespread throughout the brainstem and Sleep and circadian rhythms are generated from hypothalamus. GABAergic parvalbumin neurons specific regulatory centres, including the fore- in the basal forebrain arousal system and brain, thalamus and midbrain dopaminergic GABAergic neurons in the parafacial zone of the © Author(s) (or their medulla are essential for driving wakefulness, employer(s)) 2021. No neurons, regions also implicated in movement commercial re-use . See rights disorder pathogenesis. with the latter promoting sleep via inhibition and permissions. Published The rate, nature and temporal pattern of these of glutamatergic neurons in the parabrachial by BMJ. sleep disturbances vary across the different nucleus (PB). More recently, evidence suggests To cite: Bailey GA, Hubbard movement disorders. For example, in Parkin- that GABAergic neurons in the LH contribute EK, Fasano A, et al. J Neurol son’s disease (PD) the rate of sleep disorders has to promoting wakefulness by inhibiting the Neurosurg Psychiatry been estimated to be as high as 98%, with rapid thalamus and preoptic area. The ventrolateral 2021;92:723–736. eye movement (REM) sleep behaviour disorder preoptic area also contains GABAergic neurons, Bailey GA, et al. J Neurol Neurosurg Psychiatry 2021;92:723–736. doi:10.1136/jnnp-2020-325546 723 Movement disorders J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp-2020-325546 on 19 March 2021. Downloaded from Figure 1 Sleep hypnogram illustrating a normal sleep cycle and physiological changes. NREM1/2/3: non-r apid eye movement sleep stages 1, 2 and 3, REM sleep: rapid eye movement. NREM, non-r apid eye movement. copyright. essential for promoting sleep via inhibition of the arousal PSG is required for confirming the diagnosis of REM Sleep system. Behavioural Disorder (RBD), while PSG and multiple sleep Glutamatergic REM-promoting neurons in the sublatero- latency test (MSLT) are used in the diagnoses of narcolepsy dorsal nucleus (SLD) are inhibited by GABAergic NREM- and other central hypersomnias. promoting neurons in the vPAG, while activation of GABAergic neurons in the ventral medulla which innervate vPAG promotes transition to REM sleep by disinhibition of Technology to aid diagnostic and therapeutic management the SLD. NREM sleep is driven by GABAergic neurons in Development of consumer wearables is becoming recognised the vPAG and glutamatergic neurons located ventromedial as a prospective clinical tool, aiding early diagnosis as well as the opportunity to monitor disease progression particu- to the superior cerebellar peduncle. These neurons suppress http://jnnp.bmj.com/ both wakefulness and REM sleep by inhibiting the SLD, with larly, for example, in response to therapeutics. Actigraphy, additional inhibition of the medial PB by GABAergic neurons an accelerometer validated to detect sleep/wake activity also promoting NREM sleep. Newer models of the sleep/ patterns, is particularly useful for documenting sleep- wake wake circuit recognise that these interactions are modulated patterns for periods of days or weeks in the patient’s own by several brain regions including the PPT, laterodorsal environment, as well as measuring physical activity during tegmental nuclei (LDT), projections from the medulla and periods of wakefulness. Use of these wearable devices extends the melanin-concentrating neuron system (figure 2A,B).3 far beyond disease alone, potentially providing avenues to better understand the association between sleep and health, on September 26, 2021 by guest. Protected as well as opportunities to optimise interventions and reduce Types of sleep disorders the adverse health impacts of poor sleep. The different forms of sleep disorders, as defined by the International Classification of Sleep Disorders, their clinical features, diagnostic criteria, proposed underlying pathophys- Review of the evidence for sleep disturbance across iology and currently suggested treatments are summarised in degenerative and non-degenerative movement disorders table 1. The literature search included the key words “sleep distur- bances”, “sleep disorders”; “RLS”; “PLMS”; “sleep related Diagnosing sleep disorders breathing disorders”; “RBD”; “excessive daytime sleepi- Online supplemental table 1 summarises the available sleep ness”; “insomnia” in combination with degenerative move- questionnaires. Sleep diaries and wrist actigraphy are often
Load more

Recommended publications
  • Modafinil/Armodafinil (Provigil ® /Nuvigil
    Drug and Biologic Coverage Policy Effective Date ............................................ 7/1/2020 Next Review Date… ..................................... 7/1/2021 Coverage Policy Number .................................. 1501 Modafinil / Armodafinil for Individual and Family Plans Table of Contents Related Coverage Resources Coverage Policy ................................................... 1 Obstructive Sleep Apnea Treatment Services FDA Approved Indications ................................... 2 Recommended Dosing ........................................ 3 General Background ............................................ 3 Coding/ Billing Information ................................... 6 References .......................................................... 6 INSTRUCTIONS FOR USE The following Coverage Policy applies to health benefit plans administered by Cigna Companies. Certain Cigna Companies and/or lines of business only provide utilization review services to clients and do not make coverage determinations. References to standard benefit plan language and coverage determinations do not apply to those clients. Coverage Policies are intended to provide guidance in interpreting certain standard benefit plans administered by Cigna Companies. Please note, the terms of a customer’s particular benefit plan document [Group Service Agreement, Evidence of Coverage, Certificate of Coverage, Summary Plan Description (SPD) or similar plan document] may differ significantly from the standard benefit plans upon which these Coverage Policies
    [Show full text]
  • Excessive Daytime Somnolence S44 (1)
    EXCESSIVE DAYTIME SOMNOLENCE S44 (1) Excessive Daytime Somnolence Last updated: May 8, 2019 Clinical Features .................................................................................................................... 1 Differential Diagnosis ........................................................................................................... 2 Diagnosis ............................................................................................................................... 2 Treatment ............................................................................................................................... 2 NARCOLEPSY ........................................................................................................................................... 2 CLINICAL FEATURES .............................................................................................................................. 3 DIAGNOSIS ............................................................................................................................................. 4 MANAGEMENT ....................................................................................................................................... 4 IDIOPATHIC (PRIMARY) HYPERSOMNIA ................................................................................................. 5 KLEINE-LEVIN SYNDROME ...................................................................................................................... 6 SLEEP APNEA ..........................................................................................................................................
    [Show full text]
  • Treatment of Sleep Disorders in Dementia Sharon Ooms, Msc1,2 Yo-El Ju, MD MSCI3,*
    Curr Treat Options Neurol (2016) 18:40 DOI 10.1007/s11940-016-0424-3 Dementia (E McDade, Section Editor) Treatment of Sleep Disorders in Dementia Sharon Ooms, MSc1,2 Yo-El Ju, MD MSCI3,* Address 1Department of Geriatric Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands 2Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands *3Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, Saint Louis, MO, 63110, USA Email: [email protected] * Springer Science+Business Media New York 2016 This article is part of the Topical Collection on Dementia Keywords Sleep I Insomnia I Circadian I Dementia I Alzheimer’s disease I Dementia with Lewy bodies I Lewy body disease I Frontotemporal dementia I Parkinson’s disease with dementia I REM sleep behavior disorder Opinion statement Sleep and circadian disorders occur frequently in all types of dementia. Due to the multifactorial nature of sleep problems in dementia, we propose a structured approach to the evaluation and treatment of these patients. Primary sleep disorders such as obstructive sleep apnea should be treated first. Comorbid conditions and medications that impact sleep should be optimally managed to minimize negative effects on sleep. Patients and caregivers should maintain good sleep hygiene, and social and physical activity should be encouraged during the daytime. Given the generally benign nature of bright light therapy and melatonin, these treatments should be tried first. Pharmacolog- ical treatments should be added cautiously, due to the risk of cognitive side effects, sedation, and falls in the demented and older population. Regardless of treatment modality, it is essential to follow patients with dementia and sleep disorders closely, with serial monitoring of individual response to treatment.
    [Show full text]
  • A Comparison of Idiopathic Hypersomnia and Narcolepsy-Cataplexy Using Self Report Measures and Sleep Diary Data
    57676ournal ofNeurology, Neurosurgery, and Psychiatry 1996;60:576-578 SHORT REPORT J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.60.5.576 on 1 May 1996. Downloaded from A comparison of idiopathic hypersomnia and narcolepsy-cataplexy using self report measures and sleep diary data Dorothy Bruck, J D Parkes Abstract Published data comparing patients with IH Eighteen patients with idiopathic hyper- and patients with NLS outside the sleep labo- somnia (IH) were compared with 50 ratory are scarce. Using self report question- patients with the narcoleptic syndrome of naires and sleep diary data our aim was to cataplexy and daytime sleepiness (NLS) determine the extent of group differences and using self report questionnaires and a which variables best discriminated between IH diary of sleep/wake patterns. The IH and NLS. group reported more consolidated noc- turnal sleep, a lower propensity to nap, greater refreshment after naps, and a Patients and methods greater improvement in excessive day- DIAGNOSTIC CRITERIA time sleepiness since onset than the NLS Idiopathic hypersomnia group. In IH, the onset of excessive day- Patients were selected with a complaint of time sleepiness was predominantly asso- excessive daytime sleepiness without cataplexy ciated with familial inheritance or a viral and with no evidence of any medical, psycho- illness. Two variables-number of logical, drug related, or respiratory disorder. reported awakenings during nocturnal All patients met diagnostic criteria ascertained sleep and the reported change in sleepi- from questionnaire responses: Epworth sleepi- ness since onset-provided maximum ness scale score8 > 13; duration of excessive discrimination between the IH and NLS daytime sleepiness > five years, profile of groups.
    [Show full text]
  • Sleep Disorders in General Last Updated: May 8, 2019 CLASSIFICATION
    SLEEP DISORDERS (GENERAL) S40 (1) Sleep Disorders in General Last updated: May 8, 2019 CLASSIFICATION ...................................................................................................................................... 1 ETIOLOGY ................................................................................................................................................ 3 DIAGNOSIS................................................................................................................................................ 3 TREATMENT ............................................................................................................................................. 5 10-15% of population have sleep-related problems! CLASSIFICATION International Classification of Sleep Disorders: 1. Dyssomnias - sleep disorders that result in: 1) insomnia (perceived inability to obtain sufficient sleep) 2) excessive daytime somnolence (excessive sleepiness or fatigue during day) 2. Parasomnias - undesirable physical & mental phenomena that occur during sleep - disorders of arousal / partial arousal / sleep stage transition. 3. Sleep disorders associated with: a) psychiatric disorders (esp. depression and anxiety) – sleep disturbance may be first or most significant symptom! b) medical disorders (e.g. awakening by pain, respiratory difficulty due to asthma, urge to urinate, etc). c) neurodegenerative disorders: o neuronal systems involved in sleep-wake regulation; o neuronal systems involved with regulation of breathing during
    [Show full text]
  • Attended Polysomnography for Evaluation of Sleep Disorders
    UnitedHealthcare® Commercial Medical Policy Attended Polysomnography for Evaluation of Sleep Disorders Policy Number: 2021T0334GG Effective Date: July 1, 2021 Instructions for Use Table of Contents Page Related Commercial Policies Coverage Rationale ....................................................................... 1 • Durable Medical Equipment, Orthotics, Medical Documentation Requirements ...................................................... 3 Supplies and Repairs/ Replacements Definitions ...................................................................................... 3 • Obstructive Sleep Apnea Treatment Applicable Codes .......................................................................... 7 Description of Services ................................................................. 7 Community Plan Policy Clinical Evidence ........................................................................... 9 • Attended Polysomnography for Evaluation of Sleep U.S. Food and Drug Administration ........................................... 14 Disorders References ................................................................................... 14 Medicare Advantage Coverage Summary Policy History/Revision Information ........................................... 16 • Sleep Apnea: Diagnosis and Treatment Instructions for Use ..................................................................... 16 Coverage Rationale Home Sleep Apnea Testing Home Sleep Apnea Testing (HSAT), using a portable monitor, is medically necessary for evaluating
    [Show full text]
  • Calcium, Magnesium, Potassium, and Sodium Oxybates) Oral Solution in Adult Patients with Idiopathic Hypersomnia at 2021 American Academy of Neurology Annual Meeting
    Jazz Pharmaceuticals Presents Phase 3 Study Results of Xywav™ (calcium, magnesium, potassium, and sodium oxybates) Oral Solution in Adult Patients with Idiopathic Hypersomnia at 2021 American Academy of Neurology Annual Meeting April 20, 2021 Xywav demonstrated statistically significant differences in change in Epworth Sleepiness Scale score (p-value <0.0001), Patient Global Impression of Change (p-value <0.0001) and the Idiopathic Hypersomnia Severity Scale (p-value <0.0001) The safety profile in this study was consistent with the known safety profile of Xywav with no new safety signals observed in this population Company to host investor webcast today at 12:30 p.m. ET DUBLIN, April 20, 2021 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced positive results from the Phase 3 study of XywavTM (calcium, magnesium, potassium, and sodium oxybates) oral solution in adult patients with idiopathic hypersomnia, which will be presented during the Clinical Trials Plenary Session of the 2021 American Academy of Neurology (AAN) Annual Meeting between 10:00 a.m. and 12:30 p.m. ET. Jazz will host an investor and analyst presentation via webcast today at 12:30 p.m. ET. Today's presentation will further quantify the previously reported Phase 3 top-line results. These additional data were submitted to the U.S. Food and Drug Administration (FDA) in the supplemental New Drug Application that was recently accepted for filing and granted Priority Review. "The efficacy and safety results demonstrate the potential Xywav has for people living with idiopathic hypersomnia, a debilitating, chronic sleep disorder for which there are no approved treatments in the U.S.," said Robert Iannone, M.D., M.S.C.E., executive vice president, research and development and chief medical officer of Jazz Pharmaceuticals.
    [Show full text]
  • Idiopathic-Hypersomnia-.Pdf
    Research & Reviews: Neuroscience Idiopathic Hypersomnia Diksha Gupta1* and Trisha Chatterjee2 1Amity Institute of Pharmacy, Amity University, India 2Department of Biotechnology, Amity University, India Review Article Received date: 08/11/2016 ABSTRACT Accepted date: 27/01/2017 Sleep is an unconsciousness form by which the person Published date: 06/02/2017 could be aroused by sensory or other stimuli. These days due to psychological and social dysfunction our daily routine affects the *For Correspondence quality of our life, according to survey much health related issues are being reported due to lack of sleep. An ancient literature Gupta D, Amity University, Noida, UP, India, Tel: review was given and explained the theory about the leading 8588829759. symptom of idiopathic hypersomnia was sleep drunkenness and the first patient was thus diagnosed with prolonged nocturnal E-mail: [email protected] sleep accompanied by excessive daytime sleepiness with long naps and difficult awakening. A severe issue with this disease is Keywords: Idiopathic hypersomnia, Lengthy that most people tend to suffer from "Depression". Due to ischemic sleep, Narcolepsy, Obstructive sleep changes along the border of mesencephalon and diencephalon and post-traumatic etiology in other, people thus suffer from "sleep apnea, Narcolepsy, Bruxism, Non-rapid eye drunkenness". The term idiopathic hypersomnia was given a variety movement, Hypersomnia of clinical labels including idiopathic central nervous hypersomnia or hypersomnolence, functional hypersomnia, mixed or harmonious hypersomnia, hypersomnia with automatic behavior, and non-rapid eye movement (NREM) narcolepsy. Two different clinical forms were recommended —idiopathic hypersomnia with long sleep time and IH without long sleep time which then reappeared in the latest International Classification of Sleep Disorders.
    [Show full text]
  • Corticalâ•Fisubcortical Interactions In
    Washington University School of Medicine Digital Commons@Becker Open Access Publications 2014 Cortical–subcortical interactions in hypersomnia disorders: Mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle Linda J. Larson-Prior Washington University School of Medicine in St. Louis Yo-El Ju Washington University School of Medicine in St. Louis James E. Galvin New York University School of Medicine Follow this and additional works at: https://digitalcommons.wustl.edu/open_access_pubs Recommended Citation Larson-Prior, Linda J.; Ju, Yo-El; and Galvin, James E., ,"Cortical–subcortical interactions in hypersomnia disorders: Mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle." Frontiers in Neurology.5,. 165. (2014). https://digitalcommons.wustl.edu/open_access_pubs/3264 This Open Access Publication is brought to you for free and open access by Digital Commons@Becker. It has been accepted for inclusion in Open Access Publications by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. REVIEW ARTICLE published: 11 September 2014 doi: 10.3389/fneur.2014.00165 Cortical–subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle Linda J. Larson-Prior 1,2*,Yo-El Ju 2 and James E. Galvin3,4,5 1 Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA 2 Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA 3 Departments of Neurology, New York University Langone School of Medicine, New York, NY, USA 4 Department of Psychiatry, New York University Langone School of Medicine, New York, NY, USA 5 Department of Population Health, New York University Langone School of Medicine, New York, NY, USA Edited by: Subcortical circuits mediating sleep–wake functions have been well characterized in ani- Maria Engström, Linköping mal models, and corroborated by more recent human studies.
    [Show full text]
  • Central Disorders of Hypersomnolence, Restless Legs Syndrome, and Surgery with General Anesthesia: Patient Perceptions
    Central Disorders of Hypersomnolence, Restless Legs Syndrome, and Surgery With General Anesthesia: Patient Perceptions Vincent LaBarbera, Emory University Paul Garcia, Emory University Donald Bliwise, Emory University Lynn Marie Trotti, Emory University Journal Title: Frontiers in Human Neuroscience Volume: Volume 12 Publisher: Frontiers Media | 2018-03-20, Pages 99-99 Type of Work: Article | Final Publisher PDF Publisher DOI: 10.3389/fnhum.2018.00099 Permanent URL: https://pid.emory.edu/ark:/25593/s92v2 Final published version: http://dx.doi.org/10.3389/fnhum.2018.00099 Copyright information: © 2018 LaBarbera, García, Bliwise and Trotti. This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/). Accessed September 27, 2021 12:18 AM EDT ORIGINAL RESEARCH published: 20 March 2018 doi: 10.3389/fnhum.2018.00099 Central Disorders of Hypersomnolence, Restless Legs Syndrome, and Surgery With General Anesthesia: Patient Perceptions Vincent LaBarbera 1, Paul S. García 2,3, Donald L. Bliwise 1 and Lynn M. Trotti 1* 1 Sleep Center and Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 2 Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States, 3 Research and Anesthesiology Service Lines, Atlanta VA Medical Center, Atlanta, GA, United States Introduction: The importance of obstructive sleep apnea in patients undergoing surgery with general anesthesia is well-defined, but the surgical and anesthetic implications of other sleep disorders are less clear. We sought to evaluate response to surgery with general anesthesia in patients with central disorders of hypersomnolence or restless legs Edited by: syndrome.
    [Show full text]
  • The Prevalence and Characteristics of Primary Headache and Dream
    RESEARCH ARTICLE The Prevalence and Characteristics of Primary Headache and Dream-Enacting Behaviour in Japanese Patients with Narcolepsy or Idiopathic Hypersomnia: A Multi-Centre Cross-Sectional Study Keisuke Suzuki1*, Masayuki Miyamoto2, Tomoyuki Miyamoto3, Yuichi Inoue4, Kentaro Matsui4, Shingo Nishida4, Kenichi Hayashida5, Akira Usui4, Yoichiro Ueki5, Masaki Nakamura4, Momoyo Murata6, Ayaka Numao1, Yuji Watanabe1, Shiho Suzuki1, Koichi Hirata1 1 Department of Neurology, Dokkyo Medical University, Tochigi, Japan, 2 School of Nursing, Dokkyo Medical University, Tochigi, Japan, 3 Department of Neurology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan, 4 Yoyogi Sleep Disorder Centre, Tokyo, Japan, 5 Sleep & Stress Clinic, Tokyo, Japan, 6 Kokubunji Sakura Clinic, Tochigi, Japan OPEN ACCESS * [email protected] Citation: Suzuki K, Miyamoto M, Miyamoto T, Inoue Y, Matsui K, Nishida S, et al. (2015) The Prevalence and Characteristics of Primary Headache and Dream-Enacting Behaviour in Japanese Patients with Abstract Narcolepsy or Idiopathic Hypersomnia: A Multi- Centre Cross-Sectional Study. PLoS ONE 10(9): e0139229. doi:10.1371/journal.pone.0139229 Background Editor: Oscar Arias-Carrion, Hospital General Dr. Because the prevalence and characteristics of primary headache have yet to be thoroughly Manuel Gea González, MEXICO studied in patients with hypersomnia disorders, including narcolepsy and idiopathic hyper- Received: March 25, 2015 somnia, we examined these parameters in the Japanese population. Accepted: September 10, 2015 Published: September 29, 2015 Methods Copyright: © 2015 Suzuki et al. This is an open In a multicentre cross-sectional survey, among 576 consecutive outpatients with sleep dis- access article distributed under the terms of the orders, 68 narcolepsy patients and 35 idiopathic hypersomnia patients were included.
    [Show full text]
  • Treatment of Central Disorders of Hypersomnolence: an American Academy of Sleep Medicine Clinical Practice Guideline
    Treatment of Central Disorders of Hypersomnolence: An American Academy of Sleep Medicine Clinical Practice Guideline Introduction: This guideline establishes clinical practice recommendations for the treatment of central disorders of hypersomnolence in adults and children. Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths of treatment based on a systematic review of the literature and an assessment of the evidence using the GRADE process. The task force provided a summary of the relevant literature and the quality of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations. The AASM Board of Directors approved the final recommendations. Recommendations: The following recommendations are intended as a guide for clinicians in choosing a specific treatment for central disorders of hypersomnolence in adults and children. Each recommendation statement is assigned a strength (“Strong” or “Conditional”). A “Strong” recommendation (i.e., “We recommend…”) is one that clinicians should follow under most circumstances. A “Conditional” recommendation (i.e. “We suggest…”) is one that requires that the clinician use clinical knowledge and experience, and strongly considers the individual patient’s values and preferences to determine the best course of action. Adult patients with narcolepsy 1. We recommend that clinicians use modafinil for the treatment of narcolepsy in adults. (Strong) 2. We recommend that clinicians use pitolisant for the treatment of narcolepsy in adults. (Strong) 3. We recommend that clinicians use sodium oxybate for the treatment of narcolepsy in adults. (Strong) 4. We recommend that clinicians use solriamfetol for the treatment of narcolepsy in adults.
    [Show full text]