DOCSLIB.ORG

Sialolithiasis)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Sialolithiasis) J Clin Pathol: first published as 10.1136/jcp.41.4.403 on 1 April 1988. Downloaded from J Clin Pathol 1988;41:403-409 Clinicopathological study of myoepithelial sialadenitis and chronic sialadenitis (sialolithiasis) G M KONDRATOWICZ,* LESLEY A SMALLMAN, D W MORGANt From the *Department ofPathology, The Medical School, The University ofBirmingham, and tthe Department ofOtorhinolaryngology, The Queen Elizabeth Hospital, Birmingham SUMMARY To determine any overlap in pathological features between myoepithelial sialadenitis and chronic sialadenitis/sialolithiasis histological sections from 69 cases of myoepithelial sialadenitis (MESA) (n = 7) and chronic sialadenitis/sialolithiasis (n = 62) were reviewed over a 10 year period. Three of the cases with MESA contained calculi and four of those originally diagnosed as chronic sialadenitis/sialolithiasis showed epimyoepithelial island formation. The presence of calculi should not rule out a diagnosis of MESA, particularly in the parotid gland where calculi are uncommon; as the incidence of MESA may very well be underestimated and diagnosed as chronic sialadenitis, these patients, who are at increased risk of developing lymphoma, could be lost to follow up. Myoepithelial sialadenitis (MESA) is characterised by obtained from the files of the department of path- the formation of epimyoepithelial islands accompan- ology, University of Birmingham and the department ied by chronic lymphocytic infiltration of the salivary of histopathology, General Hospital, Birmingham. copyright. parenchyma and often glandular atrophy. It has Sections stained with haematoxylin and eosin were largely superceded the earlier used term, benign lym- reviewed and the presence or absence ofepimyoepith- phoepithelial lesion, which was coined by Godwin in elial islands, ductal infiltration by lymphoid cells, and 1952.12 calcified material noted. Other features assessed were Although the histological picture ofwell established the prominence of lobular lymphoid infiltration, MESA is usually so characteristic that there is little presence or absence of germinal centres, intra-acinar difficulty distinguishing it from other types of and ductal acute inflammatory cells, lobular and http://jcp.bmj.com/ sialadenitis, we recently saw a case of MESA in which periductal fibrosis and atrophy, and epithelioid gran- the excised parotid gland tissue contained several uloma formation. Interval sections were cut in those calcified laminated calculi situated within dilated cases showing epimyoepithelial island formation. The ducts. This feature, which initially prompted some case notes of patients diagnosed as having MESA diagnostic confusion, led us to review all the cases of or chronic sialadenitis/sialolithiasis, in which MESA and chronic sialadenitis/sialolithiasis from our epimyoepithelial islands were found were reviewed files seen over the past 10 years. The aim of this study (table). on September 24, 2021 by guest. Protected was to determine the incidence of calculi in cases diagnosed as MESA and the incidence of Results epimyoepithlial islands in otherwise typical chronic sialadenitis. We were particularly interested in cases Histological sections from a total of 73 salivary glands which may represent the development of MESA in (56 submandibular, 17 parotid) were reviewed. Two pre-existing chronic sialadenitis and the possibility of submandibular glands and six parotid glands had been any overlap between these two types of disease. reported as MESA or Sjogren's syndrome. This included one patient with two excisions over a period of several years. Chronic sialadenitis/sialolithiasis had Material and methods been diagnosed in 54 submandibular glands and eight parotid glands; calculi were noted macroscopically, or Cases diagnosed as chronic sialadenitis, sialolithiasis, microscopically, or a definite clinical history of MESA, Sj6gren's syndrome, or lymphoma were sialolithiasis had been elicited in 29 (53%) of subman- dibular glands and three (38%) of parotid glands. Of Accepted for publication 14 October 1987 the remaining three salivary glands, one was clearly a 403 J Clin Pathol: first published as 10.1136/jcp.41.4.403 on 1 April 1988. Downloaded from 404 Kondralowicz, Smallman, Morgan Table Clinical details ofcases ofMESA and chronic sialadenitis/sialolithiasis Duration of Case Age Salivary gland(s) gland symptoms Associated Serology and other No (years) Sex excised (months) Calculi diseases relevant investigations Clinical diagnosis 1 68 F Parotid 12 Absent Rheumatoid arthritis RhF positive Sj6gren's syndrome 2 45 F Parotid 5 Present Mixed collagen disease RhF positive Sj6gren's syndrome (microscopic) autoimmune throm- ANF positive bocytopaenia Schirmer's test positive 3 54 F Parotid 12 Absent ANF positive Sicca syndrome Schirmer's test positive 4 52 F Submandibular 12 Absent Rheumatoid arthritis, ANF positive Sj6gren's syndrome pernicious anaemia, Schirmer's test positive Hashimoto's thyroiditis Coomb's test positive Lymphopaenia Thrombocytopaenia 5 60 F Submandibular 6 Absent Rheumatoid arthritis RhF positive Sj6gren's syndrome Schirmer's test positive 6 42 F Both parotids 12 Present RhF positive Sicca syndrome (microscopic) ANF positive Polyclonalhypergamma- globulinaemia 7 41 F Parotid 60 Present Rheumatoid arthritis RhF positive Sj6gren's syndrome 8 65 F Parotid 180 Present Sialolithiasis 9 77 F Submandibular 36 Present Sialolithiasis 10 57 F Parotid 6 Present Sialolithiasis 11 36 M Submandibular 240 Present Sialolithiasis copyright. 14. http://jcp.bmj.com/ on September 24, 2021 by guest. Protected '* . AS - 4Y a 5 a .-'-*W .a Fig I Typical epimyoepithelial island in established MESA. Fig 2 Fragmented calculus within remains ofintralobular Many infiltrating lymphoid cells have a centrocyte-like duct (case 2). morphology at higher magnification (case 5). J Clin Pathol: first published as 10.1136/jcp.41.4.403 on 1 April 1988. Downloaded from Clinicopathological study ofmyoepithelial sialadenitis and chronic sialadenitis (sialolithiasis) 40)5 -Inimqw , .-. ... , I ,- 0 'i .4i 4 i I. N, _t * _. A. d* . A.%A%_ .-Le, 4 , ,:- 1--we --v I. L9,.W Fig 3 Dilated duct denselv infiltrated by lymphoid cells and containing calcified material (case 6). copyright. granulomatous sialadenitis, probably sarcoidosis, and the parotid cases. Male to female ratios were about 1:1 in the two others there was a history of trauma or local and 2:3, respectively. A review of these cases showed tumour resection. that epimyoepithelial islands were found in two (4%) The mean age of patients with MESA was 59 years of the submandibular glands and in two (25%) of the http://jcp.bmj.com/ (range 43-68 years); all were women (table). parotid glands. Calculi were identified either macro- Epimyoepithelial islands were found in all eight cases scopically or microscopically in all four cases (table). (fig 1). In addition, calculi were present in three (38%) Epimyoepithelial islands were small and sparse in cases, one of which was noted macroscopically on these four cases but more typical examples were slicing glandular tissue as a 0-2 cm stone (case 7). In the usually identified by interval sections through the other two cases calcified material was noted within tissue blocks (figs 4-6). A lymphoid infiltrate in the dilated ducts on histological examination (fig 2). Apart epithelium of dilated ducts as seen in MESA was from epimyoepithelial islands, an important his- present in both parotid tissue samples but not in on September 24, 2021 by guest. Protected tological feature was the presence of dilated ducts submandibular tissue; otherwise, lymphoid infiltra- infiltrated by lymphoid cells. This was seen in six ofthe tion of ductal epithelium was conspicuously absent in eight cases (75%) and was pronounced in three of the cases of chronic sialadenitis/sialolithiasis. these. In those cases containing calcified material this Occasional intraductal lymphoid cells were also was characteristically within dilated ducts of this type present as part of a granulomatous infiltrate in two of (fig 3). A dense chronic lymphoid infiltrate was also four cases of chronic sialadenitis in which sparse present around ducts and within lobules, but in most epithelioid granulomas were noted. Acute inflam- cases occasional lobules were largely spared or com- matory cells within ducts or acini were rare in the pletely devoid of infiltration. Germinal centre forma- presence of epimyoepithelial islands, but particularly tion varied from abundant to absent, but was present common in those cases of chronic sialadenitis with in most cases (75%). No cases of salivary lymphoma definite calculi (41%). A prominent lobular lymphoid had been seen over the 10 year period. infiltrate was present in seven of 54 (13%) subman- The mean age ofpatients in the chronic sialadenitis/ dibular glands, previously reported as being chronic sialolithiasis group was 44-6 years (range 13-77) for sialadenitis/sialolithiasis, but this was usually less the submandibular cases, and 57 8 years (48-65) for prominent than in the cases of MESA. J Clin Pathol: first published as 10.1136/jcp.41.4.403 on 1 April 1988. Downloaded from 406 Kondratowicz, Smallman, Morgan Fig 4 Epimyoepithelial island infiltrated by lymphoid cells in patient with clinical diagnosis ofsialolithiasis (case 9). copyright. In the parotid gland specimens this feature was manifestations can occur. The exact relation between prominent only in those cases containing this primary form and the classic secondary form is not epimyoepithelial islands.
Load more

Recommended publications
  • Juvenile Recurrent Parotitis and Sialolithiasis: an Noteworthy Co-Existence
    Otolaryngology Open Access Journal ISSN: 2476-2490 Juvenile Recurrent Parotitis and Sialolithiasis: An Noteworthy Co-Existence Venkata NR* and Sanjay H Case Report Department of ENT and Head & Neck Surgery, Kohinoor Hospital, India Volume 3 Issue 1 Received Date: April 20, 2018 *Corresponding author: Nataraj Rajanala Venkata, Department of ENT and Head & Published Date: May 21, 2018 Neck Surgery, Kohinoor Hospital, Kurla (W), Mumbai, India, Tel: +918691085580; DOI: 10.23880/ooaj-16000168 Email: [email protected] Abstract Juvenile Recurrent Parotitis is a relatively rare condition. Sialolithiasis co-existing along with Juvenile Recurrent Parotitis is an even rarer occurrence. We present a case of Juvenile Recurrent Parotitis and Sialolithiasis in a 6 years old male child and how we managed it. Keywords: Juvenile Recurrent Parotitis; Parotid gland; Swelling; Sialolithiasis Introduction child. Tuberculosis was suspected but the tests yielded no results. Even MRI of the parotid gland failed to reveal any Juvenile Recurrent Parotitis is characterized by cause. Then the patient was referred to us for definitive recurring episodes of swelling usually accompanied by management. Taking the history into consideration, a pain in the parotid gland. Associated symptoms usually probable diagnosis of Juvenile Recurrent Parotitis due to include fever and malaise. It is most commonly seen in sialectasis was considered. CT Sialography revealed children, but may persist into adulthood. Unlike parotitis, dilatation of the main duct and the ductules with which is caused by infection or obstructive causes like collection of the dye at the termination of the terminal calculi, fibromucinous plugs, duct stenosis and foreign ductules, in the left parotid gland.
    [Show full text]
  • Sjogren's Syndrome an Update on Disease Pathogenesis, Clinical
    Clinical Immunology 203 (2019) 81–121 Contents lists available at ScienceDirect Clinical Immunology journal homepage: www.elsevier.com/locate/yclim Review Article Sjogren’s syndrome: An update on disease pathogenesis, clinical T manifestations and treatment ⁎ Frederick B. Vivinoa, , Vatinee Y. Bunyab, Giacomina Massaro-Giordanob, Chadwick R. Johra, Stephanie L. Giattinoa, Annemarie Schorpiona, Brian Shaferb, Ammon Peckc, Kathy Sivilsd, ⁎ Astrid Rasmussend, John A. Chiorinie, Jing Hef, Julian L. Ambrus Jrg, a Penn Sjögren's Center, Penn Presbyterian Medical Center, University of Pennsylvania Perelman School of Medicine, 3737 Market Street, Philadelphia, PA 19104, USA b Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, 51 N. 39th Street, Philadelphia, PA 19104, USA c Department of Infectious Diseases and Immunology, University of Florida College of Veterinary Medicine, PO Box 100125, Gainesville, FL 32610, USA d Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology Program, 825 NE 13th Street, OK 73104, USA e NIH, Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, Building 10, Room 1n113, 10 Center DR Msc 1190, Bethesda, MD 20892-1190, USA f Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing 100044, China g Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA 1. Introduction/History and lacrimal glands [4,11]. The syndrome is named, however, after an Ophthalmologist from Jonkoping, Sweden, Dr Henrik Sjogren, who in Sjogren’s syndrome (SS) is one of the most common autoimmune 1930 noted a patient with low secretions from the salivary and lacrimal diseases. It may exist as either a primary syndrome or as a secondary glands.
    [Show full text]
  • Parotid Sialolithiasis and Sialadenitis in a 3-Year-Old Child
    Ahmad Tarmizi et al. Egyptian Pediatric Association Gazette (2020) 68:29 Egyptian Pediatric https://doi.org/10.1186/s43054-020-00041-z Association Gazette CASE REPORT Open Access Parotid sialolithiasis and sialadenitis in a 3- year-old child: a case report and review of the literature Nur Eliana Ahmad Tarmizi1, Suhana Abdul Rahim2, Avatar Singh Mohan Singh2, Lina Ling Chooi2, Ong Fei Ming2 and Lum Sai Guan1* Abstract Background: Salivary gland calculi are common in adults but rare in the paediatric population. It accounts for only 3% of all cases of sialolithiasis. Parotid ductal calculus is rare as compared to submandibular ductal calculus. Case presentation: A 3-year-old boy presented with acute painful right parotid swelling with pus discharge from the Stensen duct. Computed tomography revealed calculus obstructing the parotid duct causing proximal ductal dilatation and parotid gland and masseter muscle oedema. The child was treated with conservative measures, and subsequently the swelling and calculus resolved. Conclusions: Small parotid duct calculus in children may be successfully treated with conservative measures which obviate the need for surgery. We discuss the management of parotid sialolithiasis in children and conduct literature search on the similar topic. Keywords: Sialolithiasis, Sialadenitis, Salivary calculi, Parotid gland, Salivary ducts, Paediatrics Background performing computed tomography (CT) of the neck. Sialolithiasis is an obstructive disorder of salivary ductal The unusual presentation, CT findings and its subse- system caused by formation of stones within the salivary quent management were discussed. gland or its excretory duct [1]. The resulting salivary flow obstruction leads to salivary ectasia, gland dilatation Case presentation and ascending infection [2].
    [Show full text]
  • Pratiqueclinique
    Pratique CLINIQUE Sympathetically Maintained Pain Presenting First as Temporomandibular Disorder, then as Parotid Dysfunction Auteur-ressource Subha Giri, BDS, MS; Donald Nixdorf, DDS, MS Dr Nixdorf Courriel : nixdorf@ umn.edu SOMMAIRE Le syndrome douloureux régional complexe (SDRC) est un état chronique qui se carac- térise par une douleur intense, de l’œdème, des rougeurs, une hypersensibilité et des effets sudomoteurs accrus. Dans les 13 cas de SDRC siégeant dans la région de la tête et du cou qui ont été recensés dans la littérature, il a été établi que l’étiologie de la douleur était une lésion nerveuse. Dans cet article, nous présentons le cas d’une femme de 30 ans souffrant de douleur maintenue par le système sympathique, sans lésion nerveuse appa- rente. Ses principaux symptômes – douleur préauriculaire gauche et incapacité d’ouvrir grand la bouche – simulaient une arthralgie temporomandibulaire et une douleur myo- faciale des muscles masticateurs. Puis sont apparus une douleur préauriculaire intermit- tente et de l’œdème accompagnés d’hyposalivation – des signes cette fois-ci évocateurs d’une parotidite. Après une évaluation diagnostique exhaustive, aucune pathologie sous-jacente précise n’a pu être déterminée et un diagnostic de douleur névropathique à forte composante sympathique a été posé. Deux ans après l’apparition des symptômes et le début des soins, un traitement combinant des blocs répétés du ganglion cervico- thoracique et une pharmacothérapie (clonidine en perfusion entérale) a procuré un sou- lagement adéquat de la douleur. Mots clés MeSH : complex regional pain syndrome; pain, intractable; parotitis; temporomandibular joint disorders Pour les citations, la version définitive de cet article est la version électronique : www.cda-adc.ca/jcda/vol-73/issue-2/163.html omplex regional pain syndrome (CRPS) • onset following an initiating noxious is a chronic condition that usually affects event (CRPS-type I) or nerve injury (CRPS- Cextremities, such as the arms or legs.
    [Show full text]
  • Current Opinions in Sialolithiasis Diagnosis and Treatment Attuali Conoscenze Nella Diagnosi E Trattamento Della Scialolitiasi
    ACTA OTORHINOLARYNGOL ITAL 25, 145-149, 2005 ROUND TABLE 91ST NATIONAL CONGRESS S.I.O. Current opinions in sialolithiasis diagnosis and treatment Attuali conoscenze nella diagnosi e trattamento della scialolitiasi M. ANDRETTA, A. TREGNAGHI1, V. PROSENIKLIEV, A. STAFFIERI ORL Clinic, Department of Surgery; 1 Institute of Radiology, University of Padua, Italy Key words Parole chiave Salivary glands • Sialolithiasis • Diagnosis • Treatment • Ghiandole salivari • Litotrissia • Diagnosi • Terapia • Sialo-MRI • Lithotripsy Scialo-RM • Scialolitiasi Summary Riassunto The introduction, 15 years ago, of extracorporeal shock L’introduzione, 15 anni fa, della litotrissia extracorporea con wave lithotripsy in the treatment of salivary gland calculi, onde d’urto (ESWL) nella terapia della calcolosi salivare ha has changed the therapeutic approach in these patients. Aim cambiato radicalmente l’approccio terapeutico di questi pa- of this study was to evaluate the efficacy of lithotripsy in zienti. L’obiettivo del nostro studio è stato quello di valutare sialolithiasis, after 10 years follow-up. A review has been l’efficacia terapeutica della litotrissia nei pazienti con scialo- made of the literature to establish current opinions in diag- litiasi, tramite un follow-up a lungo termine (10 anni). È stata, nosis and treatment of sialolithiasis. The role of ultra- inoltre, effettuata una revisione della letteratura con lo scopo sonography, radiography and, in particular, of sialo- di valutare le attuali conoscenze riguardanti la diagnosi e la magnetic resonance imaging in diagnosis of salivary lithi- terapia di questa patologia. È stato, poi, valutato il ruolo del- asis has been evaluated. The greater efficiency of the extra- l’ecografia, della radiografia ed in particolare della scialo- corporeal shock wave lithotripsy treatment for parotid, RM nella diagnosi di calcolosi salivare.
    [Show full text]
  • Sialolithiasis of Minor Salivary Glands
    + MODEL Journal of Dental Sciences (2015) xx,1e4 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.e-jds.com ORIGINAL ARTICLE Sialolithiasis of minor salivary glands: A review of 17 cases Wen-Chen Wang a,b,c, Ching-Yi Chen c, Hen-Jen Hsu e, Jer-Haur Kuo b,c, Li-Min Lin b,c,d, Yuk-Kwan Chen b,c,d* a Dental Department, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan b School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan c Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan d Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan e Division of Oral & Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Received 22 July 2015; Final revision received 18 September 2015 Available online --- KEYWORDS Abstract Background/purpose: To our knowledge, sialolithiasis in minor salivary glands is minor salivary gland; very rare, and information about the disease is limited. The current study aimed to provide sialolith; updated data regarding the disease in Taiwan. The data were compared with those of previous sialolithiasis case series studies. Materials and methods: The features of 17 cases of histopathologically confirmed sialolithiasis in minor salivary glands between 1991 and 2015 in our institution were retrospectively analyzed. Results: Most of the patients were male (n Z 14; 82.35%), with only three female patients (17.65%). The mean age of the 17 patients was 62.93 years (range, 35e82 years). Fifteen cases (w88%) were found within the 6the9th decades. Seven cases (w41%) were identified in patients aged 70 years, six of which had been diagnosed in the most recent 5 years (2011e2015).
    [Show full text]
  • Orofacial Manifestations of COVID-19: a Brief Review of the Published Literature
    CRITICAL REVIEW Oral Pathology Orofacial manifestations of COVID-19: a brief review of the published literature Esam HALBOUB(a) Abstract: Coronavirus disease 2019 (COVID-19) has spread Sadeq Ali AL-MAWERI(b) exponentially across the world. The typical manifestations of Rawan Hejji ALANAZI(c) COVID-19 include fever, dry cough, headache and fatigue. However, Nashwan Mohammed QAID(d) atypical presentations of COVID-19 are being increasingly reported. Saleem ABDULRAB(e) Recently, a number of studies have recognized various mucocutaneous manifestations associated with COVID-19. This study sought to (a) Jazan University, College of Dentistry, summarize the available literature and provide an overview of the Department of Maxillofacial Surgery and potential orofacial manifestations of COVID-19. An online literature Diagnostic Sciences, Jazan, Saudi Arabia. search in the PubMed and Scopus databases was conducted to retrieve (b) AlFarabi College of Dentistry and Nursing, the relevant studies published up to July 2020. Original studies Department of Oral Medicine and published in English that reported orofacial manifestations in patients Diagnostic Sciences, Riyadh, Saudi Arabia. with laboratory-confirmed COVID-19 were included; this yielded 16 (c) AlFarabi College of Dentistry and Nursing, articles involving 25 COVID-19-positive patients. The results showed a Department of Oral Medicine and Diagnostic Sciences, Riyadh, Saudi Arabia. marked heterogeneity in COVID-19-associated orofacial manifestations. The most common orofacial manifestations were ulcerative lesions, (d) AlFarabi College of Dentistry and Nursing, Department of Restorative Dental Sciences, vesiculobullous/macular lesions, and acute sialadentitis of the parotid Riyadh, Saudi Arabia. gland (parotitis). In four cases, oral manifestations were the first signs of (e) Primary Health Care Corporation, Madinat COVID-19.
    [Show full text]
  • Oral Manifestations of Systemic Disease Their Clinical Practice
    ARTICLE Oral manifestations of systemic disease ©corbac40/iStock/Getty Plus Images S. R. Porter,1 V. Mercadente2 and S. Fedele3 provide a succinct review of oral mucosal and salivary gland disorders that may arise as a consequence of systemic disease. While the majority of disorders of the mouth are centred upon the focus of therapy; and/or 3) the dominant cause of a lessening of the direct action of plaque, the oral tissues can be subject to change affected person’s quality of life. The oral features that an oral healthcare or damage as a consequence of disease that predominantly affects provider may witness will often be dependent upon the nature of other body systems. Such oral manifestations of systemic disease their clinical practice. For example, specialists of paediatric dentistry can be highly variable in both frequency and presentation. As and orthodontics are likely to encounter the oral features of patients lifespan increases and medical care becomes ever more complex with congenital disease while those specialties allied to disease of and effective it is likely that the numbers of individuals with adulthood may see manifestations of infectious, immunologically- oral manifestations of systemic disease will continue to rise. mediated or malignant disease. The present article aims to provide This article provides a succinct review of oral manifestations a succinct review of the oral manifestations of systemic disease of of systemic disease. It focuses upon oral mucosal and salivary patients likely to attend oral medicine services. The review will focus gland disorders that may arise as a consequence of systemic upon disorders affecting the oral mucosa and salivary glands – as disease.
    [Show full text]
  • For Immediate Release
    For Immediate Release Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Takashi Shoda, President and CEO (Code no.: 4568, First Section, Tokyo, Osaka, and Nagoya Stock Exchanges) Please address inquiries to Toshiaki Sai, General Manager, Corporate Communications Department Telephone: +81-3-6225-1126 http://www.daiichisankyo.com/ Daiichi Sankyo Launches new Cravit® Formulations in Japan TOKYO, Japan (July 7, 2009) – Daiichi Sankyo Company, Limited (TSE: 4568), today launched new formulations of Cravit® (generic name: Levofloxacin Hydrate), a broad-spectrum oral anti-bacterial agent. These formulations are 500mg and 250mg tablets, and a 10% fine granular preparation in Japan. The company obtained manufacturing and marketing approval on April 22. The drug price listing was on June 19. Daiichi Sankyo drew on PK-PD theory (see note below) to develop the once-daily dosage for the 500mg Cravit® tablet. This tablet lifts the maximum blood concentration and is significantly more bactericidal than the 100mg formulation, taken three times daily, suppressing the development of drug-resistant bacteria. The once-daily dosage of the Cravit® 500mg tablet is an approved standard in more than 120 countries and territories. Since its introduction in December 1993 in Japan, Cravit® has gained approval for treating 43 indications and 32 bacteria. This agent continues to offer outstanding efficacy, and has won accolades for its safety profile. Daiichi Sankyo is confident that its concept of a once-daily dosage of a 500mg tablet will win broad acceptance for improved efficacy and a better suppression of strong bacteria. The company will cultivate this product as a worthy contributor to long-term treatment.
    [Show full text]
  • Prevalence of Salivary Gland Disease in Patients Visiting a Private Dental
    European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 07, Issue 01, 2020 PREVALENCE OF SALIVARY GLAND DISEASE IN PATIENTS VISITING A PRIVATE DENTAL COLLEGE 1Dr.Abarna Jawahar, 2Dr.G.Maragathavalli, 3Dr.Manjari Chaudhary 1Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India 2Professor, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences(SIMATS), Saveetha University, Chennai, India 3Senior Lecturer, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences(SIMATS), Saveetha University, Chennai, India [email protected] [email protected] [email protected] ABSTRACT: The aim of the study was to estimate the prevalence of salivary gland diseases in patients visiting a private dental college. A retrospective analysis was conducted on patients who visited the Department of Oral Medicine from March 2019 to March 2020.Clinically diagnosed cases of salivary gland diseases which included salivary gland neoplasms, xerostomia, necrotizing sialometaplasia, mucocele, ranula, sjogren’s syndrome, sialodochitis, sialadenitis were included in the study.The details of each case were reviewed from an electronic database.From the study we found that 17 patients were diagnosed with salivary gland disease.The most commonly observed salivary gland disease was mucocele of the lip with a frequency of 41.17% in the study population followed by xerostomia (17.65%).Salivary gland disease can occur due to variable causes and might significantly affect the quality of life and daily functioning.Only with a thorough knowledge of the subject it is possible to detect the diseases of the salivary gland in their early stage and manage them more efficiently.
    [Show full text]
  • Salivary Gland Imaging in Sjogren's Syndrome
    REVIEW Salivary gland imaging in Sjogren’s syndrome Susan I Lemon, Sjogren’s syndrome (SS) is a systemic connective tissue disease characterized by a Steven G Imbesi & progressive immune-mediated impairment of the exocrine glands. The high prevalence in Alexander R Shikhman† the general population of sicca and other symptoms mimicking SS has increased the need †Author for correspondence for accurate tools in its diagnosis. Imaging may be substantially helpful in this regard, as Scripps Clinic, Member of the well as in the assessment of acute and chronic complications of the disease. A future Division of Rheumatology, MS113, 10666 North Torrey, application of salivary imaging in SS may be guiding therapeutics by enabling Pines Road, La Jolla, radiographic monitoring of treatment responsiveness. This review of salivary gland imaging CA 92037, USA in SS summarizes the types of information yielded by currently available modalities and Tel.: +1 858 554 8562; suggests their proper clinical application. It emphasizes recent advances in noninvasive Fax: +1 858 554 6763; imaging, including magnetic resonance sialography, ultrasonography and nuclear [email protected] medicine techniques. Sjogren’s syndrome (SS) is a systemic connective atrophic and, finally, destroyed [8]. Eventually, the tissue disease characterized by a progressive only remaining ductal epithelium consists of iso- immune-mediated impairment of the exocrine lated cell clusters of epithelial and myoepithelial glands [1,2]. Common clinical manifestations of cells surrounded by a dense lymphocytic infiltra- exocrine involvement in SS include keratocon- tion (a benign lymphoepithelial lesion) [9]. These junctivitis sicca, xerostomia and episodic glandu- pathological changes lead to salivary gland hypo- lar swelling.
    [Show full text]
  • Clinical Features and Histological Description of Tongue Lesions in a Large Northern Italian Population
    Med Oral Patol Oral Cir Bucal. 2015 Sep 1;20 (5):e560-5. Retrospective study on tongue lesions Journal section: Oral Medicine and Pathology doi:10.4317/medoral.20556 Publication Types: Research http://dx.doi.org/doi:10.4317/medoral.20556 Clinical features and histological description of tongue lesions in a large Northern Italian population Alessio Gambino 1, Mario Carbone 1, Paolo-Giacomo Arduino 1, Marco Carrozzo 2, Davide Conrotto 1, Carlotta Tanteri 1, Lucio Carbone 3, Alessandra Elia 1, Zaira Maragon 3, Roberto Broccoletti 1 1 Department of Surgical Sciences, Oral Medicine Section, CIR - Dental School, University of Turin, Turin, Italy 2 Oral Medicine Department, Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, UK 3 Private practice, Turin Correspondence: Oral Medicine Section University of Turin CIR – Dental School Gambino A, Carbone M, Arduino PG, Carrozzo M, Conrotto D, Tanteri Via Nizza 230, 10126 C, Carbone L, Elia A, Maragon Z, Broccoletti R. Clinical features and Turin, Italy histological description of tongue lesions in a lar�������������������������ge Northern Italian popu- [email protected] lation. Med Oral Patol Oral Cir Bucal. 2015 Sep 1;20 (5):e560-5. http://www.medicinaoral.com/medoralfree01/v20i5/medoralv20i5p560.pdf Article Number: 20556 http://www.medicinaoral.com/ Received: 21/12/2014 © Medicina Oral S. L. C.I.F. B 96689336 - pISSN 1698-4447 - eISSN: 1698-6946 Accepted: 25/04/2015 eMail: [email protected] Indexed in: Science Citation Index Expanded Journal Citation Reports Index Medicus, MEDLINE, PubMed Scopus, Embase and Emcare Indice Médico Español Abstract Background: Only few studies on tongue lesions considered sizable populations, and contemporary literature does not provide a valid report regarding the epidemiology of tongue lesions within the Italian population.
    [Show full text]