DOCSLIB.ORG

(Focus Score) in Smoking Patients. Can Tobacco Diminish the Salivary Gland

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(Focus Score) in Smoking Patients. Can Tobacco Diminish the Salivary Gland 54 Ann Rheum Dis 2000;59:54–60 CONCISE REPORTS Ann Rheum Dis: first published as 10.1136/ard.59.1.54 on 1 January 2000. Downloaded from Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjögren’s syndrome? R Manthorpe, C Benoni, L Jacobsson, Z Kirtava, Å Larsson, R Liedholm, C Nyhagen, H Tabery, E Theander Sjögren’s Syndrome Research Centre, Division of Rheumatology, Department of Abstract Cigarette smoking at the time of lower lip Internal Medicine, Objectives—Prospectively collected com- biopsy is associated with lower risk of Malmö University puter database information was previ- abnormal focus score (p<0.001; odds ratio Hospital, S-205 02 Malmö, Sweden ously assessed on a cohort of 300 patients 0.29, 95%CI 0.16 to 0.50). The odds ratio R Manthorpe who fulfilled the Copenhagen classifica- for having focal sialadenitis (focus score > L Jacobsson tion criteria for primary Sjögren’s syn- 1) compared with having a non-focal C Nyhagen drome. Analysis of the clinical data sialadenitis or normal biopsy (focus score E Theander showed that patients who smoked had a < 1) was decreased in all three age groups Sjögren’s Syndrome decreased lower lip salivary gland focus (10–45: odds ratio 0.27, 95%CI 0.11 to 0.71; Research Centre, score (p<0.05). The aim of this original 46–60: odds ratio 0.22, 95%CI 0.08 to 0.59; Division of report is to describe the tobacco habits in and > 61: odds ratio 0.36, 95%CI 0.10 to Gastroenterology, patients with primary Sjögren’s syndrome 1.43) although there was only statistical Department of or stomatitis sicca only and to determine significance in the two younger age Internal Medicine C Benoni if there is a correlation between smoking groups. Moreover, among current smok- habits and focus score in lower lip biopsies ers at the time of the lower lip biopsy there http://ard.bmj.com/ National Information as well as ciculating autoantibodies and was a decreasing odds ratio for an abnor- Learning Centre of the IgG. mal lip focus score with increasing Ministry of Health of Methods—All living patients with primary number of cigarettes smoked per week (p Georgia and Sjögren’s syndrome or stomatitis sicca trend 0.00). In the group of former smok- Department of Clinical Pharmacology, Tbilisi only, who were still in contact with the ers, which included patients that had State Medical Sjögren’s Syndrome Research Centre stopped smoking up to 30 years ago, the University, Tbilisi, were asked to fill in a detailed question- results were in between those of the smok- Georgia naire concerning present and past smok- ers and the historical non-smokers (odds on September 27, 2021 by guest. Protected copyright. Z Kirtava ing habits, which was compared with ratio 0.57, 95%CI 0.34 to 0.97, compared Sjögren’s Syndrome smoking habits in a sex and age matched with never smokers). Present or past Research Centre, control group (n=3700) from the general smoking did not correlate with the func- Department of Oral population. In addition, the patients pre- tion of the salivary glands as judged by Pathology, Centre for vious lower lip biopsies were blindly unstimulated whole sialometry, stimu- Oral Health Sciences re-evaluated and divided by the presence lated whole sialometry or salivary gland Å Larsson of focus score (focus score = number of scintigraphy. Among former smokers, the 2 Sjögren’s Syndrome lymphocyte foci per 4 mm glandular median time lapse between the first symp- Research Centre, tissue) into those being normal (focus tom of primary Sjögren’s syndrome and Department of Oral score ≤ 1) or abnormal (focus score > 1). the performance of the lower lip biopsy Surgery and Oral Furthermore the cohort was divided into was approximately half as long as the Medicine, Centre for Oral Health Sciences three groups; 10–45, 46–60 and > 61 years median time lapse between smoking ces- R Liedholm of age. Finally the focus score was related sation and biopsy (8 versus 15 years). to the smoking habits. Seroimmunological Hence, symptoms of Sjögren’s syndrome Sjögren’s Syndrome (ANA; anti-SSA/Ro antibodies; anti- are unlikely to have had a significant Research Centre, SSB/La antibodies; IgM-RF and IgG) influence on smoking habits at the time Department of samples were analysed routinely. of the biopsy. Among the seroimmuno- Ophthalmology H Tabery Results—The questionnaire was answered logical results only anti-SSA/Ro and anti- by 98% (n=355) of the cohort and the per- SSB/La antibodies reached statistical Correspondence to: centage of current smokers, former smok- significance in a manner similar to the Dr R Manthorpe ers and historical non-smokers at the time way smoking influenced the focus score in Accepted for publication of lower lip biopsy was not statistically dif- lower lip biopsies. On the other hand the 26 August 1999 ferent from that of the control group. level of significance was consistently more Lower frequency of focal lip sialadenitis in smoking patients 55 pronounced for the influence of smoking score (focus score = number of lymphocyte foci Ann Rheum Dis: first published as 10.1136/ard.59.1.54 on 1 January 2000. Downloaded from on the focus score than for the influence per4mm2 glandular tissue; normal focus score on anti-SSA/Ro and anti-SSB/La auto- < 1) compared with non-smokers (unpub- antibodies. lished data). To evaluate if this eVect was Conclusion—This is believed to be the dependent on the dose of tobacco or on the first report showing that cigarette smok- initiation or termination of smoking, we mailed ing is negatively associated with focal our present patients a questionnaire concern- sialadenitis—focus score >1—in lower lip ing past and present tobacco habits. In addition biopsy in patients with primary Sjögren’s the patients’ previous lower lip biopsy data syndrome. Furthermore, tobacco seems were blindly re-evaluated. to decrease the focus score in a dose The purpose of this report is to describe the dependent manner. Smoking may also tobacco habits in patients with primary SS or negatively influence the presence of anti- stomatitis sicca only and to determine if there is SSA/Ro and/or anti-SSB/La antibodies in a correlation between smoking habits and focus circulating blood. Thus, smoking habits of score in lower lip biopsies as well as circulating patients might invalidate the use of both autoantibodies and IgG. The null hypothesis lower lip salivary gland focus score and of stated that there was an equal percentage of anti-SSA/anti-SSB antibodies. It is sug- focal sialadenitis (focus score > 1) in the lower gested that the simultaneous performance lip biopsy among smoking and non-smoking of other objective tests is required to avoid patients with primary SS. misdiagnosis of oral involvement in smok- ing and former smoking patients. There- fore, classification criteria for Sjögren’s Methods syndrome that more or less rely on an PATIENTS AND DEFINITIONS Since late 1984 we have prospectively compu- abnormal focus score and/or presence of terised symptoms, signs, haematological, sero- anti-SSA/anti-SSB antibodies should be logical and immunological data from patients used with great caution. fulfilling the Copenhagen classification criteria (Ann Rheum Dis 2000;59:54–60) for primary SS.9 Diagnosis was based on at least two abnormal objective tests for the lach- Smoking is generally considered to be a great rymal glands (keratoconjunctivitis sicca) and at health hazard leading to increased socioeco- least two abnormal objective test for the nomic expense and premature death. In salivary glands (stomatitis sicca). In patients contrast, some immunological disorders seem with normal lower lip focus score (<1) at least to be negatively associated with smoking. two other objective oral tests should be abnor- These include aphthous stomatitis,1 extrinsic mal before the requirement for stomatitis sicca alveolitis, sarcoidosis and hay fever (reviewed is fulfilled—most often unstimulated whole by Baron2). sialometry (abnormal if ≤ 1.5 ml/15 min) and In ulcerative colitis, smoking seems to have a salivary gland scintigraphy, but a few times http://ard.bmj.com/ beneficial eVect as smokers have a reduced risk sialography was used. and former smokers an increased risk of devel- As our prospective data did not contain a oping the disease.3 The reason for this protec- detailed tobacco history, we mailed a question- tive eVect is not known. Nicotine has proved naire (see below) to those patients still being eVective only when added to standard treat- seen at our SS Research Centre. New patients ments in moderately active disease4 and not in were asked to fill in the smoking questionnaire maintaining remission.5 as well. A negative association such as a protective on September 27, 2021 by guest. Protected copyright. eVect of smoking seems also to exist for SMOKING QUESTIONNAIRE younger cases of Parkinson’s disease6 while The formula had the following questions: advancing age showed a significant positive (1) Are you a current smoker? If yes, (a) Do trend association.6 Both in Parkinson’s and you smoke regularly? or (b) irregularly? Alzheimer’s diseases the nicotine system in- Note: As many patients consider them- volvement may lead to new treatment selves as only feast smokers, both sub- strategies.78 groups should state the year they started Primary Sjögren’s syndrome (SS) is a and the number of cigarettes (or packages) systemic rheumatological disorder with a smoked per week. frequency that seems to exceed that of other (2) Are you a former smoker? If yes, (a) What systemic rheumatic diseases.
Load more

Recommended publications
  • Sjogren's Syndrome an Update on Disease Pathogenesis, Clinical
    Clinical Immunology 203 (2019) 81–121 Contents lists available at ScienceDirect Clinical Immunology journal homepage: www.elsevier.com/locate/yclim Review Article Sjogren’s syndrome: An update on disease pathogenesis, clinical T manifestations and treatment ⁎ Frederick B. Vivinoa, , Vatinee Y. Bunyab, Giacomina Massaro-Giordanob, Chadwick R. Johra, Stephanie L. Giattinoa, Annemarie Schorpiona, Brian Shaferb, Ammon Peckc, Kathy Sivilsd, ⁎ Astrid Rasmussend, John A. Chiorinie, Jing Hef, Julian L. Ambrus Jrg, a Penn Sjögren's Center, Penn Presbyterian Medical Center, University of Pennsylvania Perelman School of Medicine, 3737 Market Street, Philadelphia, PA 19104, USA b Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, 51 N. 39th Street, Philadelphia, PA 19104, USA c Department of Infectious Diseases and Immunology, University of Florida College of Veterinary Medicine, PO Box 100125, Gainesville, FL 32610, USA d Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology Program, 825 NE 13th Street, OK 73104, USA e NIH, Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, Building 10, Room 1n113, 10 Center DR Msc 1190, Bethesda, MD 20892-1190, USA f Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing 100044, China g Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA 1. Introduction/History and lacrimal glands [4,11]. The syndrome is named, however, after an Ophthalmologist from Jonkoping, Sweden, Dr Henrik Sjogren, who in Sjogren’s syndrome (SS) is one of the most common autoimmune 1930 noted a patient with low secretions from the salivary and lacrimal diseases. It may exist as either a primary syndrome or as a secondary glands.
    [Show full text]
  • Parotid Sialolithiasis and Sialadenitis in a 3-Year-Old Child
    Ahmad Tarmizi et al. Egyptian Pediatric Association Gazette (2020) 68:29 Egyptian Pediatric https://doi.org/10.1186/s43054-020-00041-z Association Gazette CASE REPORT Open Access Parotid sialolithiasis and sialadenitis in a 3- year-old child: a case report and review of the literature Nur Eliana Ahmad Tarmizi1, Suhana Abdul Rahim2, Avatar Singh Mohan Singh2, Lina Ling Chooi2, Ong Fei Ming2 and Lum Sai Guan1* Abstract Background: Salivary gland calculi are common in adults but rare in the paediatric population. It accounts for only 3% of all cases of sialolithiasis. Parotid ductal calculus is rare as compared to submandibular ductal calculus. Case presentation: A 3-year-old boy presented with acute painful right parotid swelling with pus discharge from the Stensen duct. Computed tomography revealed calculus obstructing the parotid duct causing proximal ductal dilatation and parotid gland and masseter muscle oedema. The child was treated with conservative measures, and subsequently the swelling and calculus resolved. Conclusions: Small parotid duct calculus in children may be successfully treated with conservative measures which obviate the need for surgery. We discuss the management of parotid sialolithiasis in children and conduct literature search on the similar topic. Keywords: Sialolithiasis, Sialadenitis, Salivary calculi, Parotid gland, Salivary ducts, Paediatrics Background performing computed tomography (CT) of the neck. Sialolithiasis is an obstructive disorder of salivary ductal The unusual presentation, CT findings and its subse- system caused by formation of stones within the salivary quent management were discussed. gland or its excretory duct [1]. The resulting salivary flow obstruction leads to salivary ectasia, gland dilatation Case presentation and ascending infection [2].
    [Show full text]
  • Orofacial Manifestations of COVID-19: a Brief Review of the Published Literature
    CRITICAL REVIEW Oral Pathology Orofacial manifestations of COVID-19: a brief review of the published literature Esam HALBOUB(a) Abstract: Coronavirus disease 2019 (COVID-19) has spread Sadeq Ali AL-MAWERI(b) exponentially across the world. The typical manifestations of Rawan Hejji ALANAZI(c) COVID-19 include fever, dry cough, headache and fatigue. However, Nashwan Mohammed QAID(d) atypical presentations of COVID-19 are being increasingly reported. Saleem ABDULRAB(e) Recently, a number of studies have recognized various mucocutaneous manifestations associated with COVID-19. This study sought to (a) Jazan University, College of Dentistry, summarize the available literature and provide an overview of the Department of Maxillofacial Surgery and potential orofacial manifestations of COVID-19. An online literature Diagnostic Sciences, Jazan, Saudi Arabia. search in the PubMed and Scopus databases was conducted to retrieve (b) AlFarabi College of Dentistry and Nursing, the relevant studies published up to July 2020. Original studies Department of Oral Medicine and published in English that reported orofacial manifestations in patients Diagnostic Sciences, Riyadh, Saudi Arabia. with laboratory-confirmed COVID-19 were included; this yielded 16 (c) AlFarabi College of Dentistry and Nursing, articles involving 25 COVID-19-positive patients. The results showed a Department of Oral Medicine and Diagnostic Sciences, Riyadh, Saudi Arabia. marked heterogeneity in COVID-19-associated orofacial manifestations. The most common orofacial manifestations were ulcerative lesions, (d) AlFarabi College of Dentistry and Nursing, Department of Restorative Dental Sciences, vesiculobullous/macular lesions, and acute sialadentitis of the parotid Riyadh, Saudi Arabia. gland (parotitis). In four cases, oral manifestations were the first signs of (e) Primary Health Care Corporation, Madinat COVID-19.
    [Show full text]
  • Oral Manifestations of Systemic Disease Their Clinical Practice
    ARTICLE Oral manifestations of systemic disease ©corbac40/iStock/Getty Plus Images S. R. Porter,1 V. Mercadente2 and S. Fedele3 provide a succinct review of oral mucosal and salivary gland disorders that may arise as a consequence of systemic disease. While the majority of disorders of the mouth are centred upon the focus of therapy; and/or 3) the dominant cause of a lessening of the direct action of plaque, the oral tissues can be subject to change affected person’s quality of life. The oral features that an oral healthcare or damage as a consequence of disease that predominantly affects provider may witness will often be dependent upon the nature of other body systems. Such oral manifestations of systemic disease their clinical practice. For example, specialists of paediatric dentistry can be highly variable in both frequency and presentation. As and orthodontics are likely to encounter the oral features of patients lifespan increases and medical care becomes ever more complex with congenital disease while those specialties allied to disease of and effective it is likely that the numbers of individuals with adulthood may see manifestations of infectious, immunologically- oral manifestations of systemic disease will continue to rise. mediated or malignant disease. The present article aims to provide This article provides a succinct review of oral manifestations a succinct review of the oral manifestations of systemic disease of of systemic disease. It focuses upon oral mucosal and salivary patients likely to attend oral medicine services. The review will focus gland disorders that may arise as a consequence of systemic upon disorders affecting the oral mucosa and salivary glands – as disease.
    [Show full text]
  • For Immediate Release
    For Immediate Release Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Takashi Shoda, President and CEO (Code no.: 4568, First Section, Tokyo, Osaka, and Nagoya Stock Exchanges) Please address inquiries to Toshiaki Sai, General Manager, Corporate Communications Department Telephone: +81-3-6225-1126 http://www.daiichisankyo.com/ Daiichi Sankyo Launches new Cravit® Formulations in Japan TOKYO, Japan (July 7, 2009) – Daiichi Sankyo Company, Limited (TSE: 4568), today launched new formulations of Cravit® (generic name: Levofloxacin Hydrate), a broad-spectrum oral anti-bacterial agent. These formulations are 500mg and 250mg tablets, and a 10% fine granular preparation in Japan. The company obtained manufacturing and marketing approval on April 22. The drug price listing was on June 19. Daiichi Sankyo drew on PK-PD theory (see note below) to develop the once-daily dosage for the 500mg Cravit® tablet. This tablet lifts the maximum blood concentration and is significantly more bactericidal than the 100mg formulation, taken three times daily, suppressing the development of drug-resistant bacteria. The once-daily dosage of the Cravit® 500mg tablet is an approved standard in more than 120 countries and territories. Since its introduction in December 1993 in Japan, Cravit® has gained approval for treating 43 indications and 32 bacteria. This agent continues to offer outstanding efficacy, and has won accolades for its safety profile. Daiichi Sankyo is confident that its concept of a once-daily dosage of a 500mg tablet will win broad acceptance for improved efficacy and a better suppression of strong bacteria. The company will cultivate this product as a worthy contributor to long-term treatment.
    [Show full text]
  • Prevalence of Salivary Gland Disease in Patients Visiting a Private Dental
    European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 07, Issue 01, 2020 PREVALENCE OF SALIVARY GLAND DISEASE IN PATIENTS VISITING A PRIVATE DENTAL COLLEGE 1Dr.Abarna Jawahar, 2Dr.G.Maragathavalli, 3Dr.Manjari Chaudhary 1Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India 2Professor, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences(SIMATS), Saveetha University, Chennai, India 3Senior Lecturer, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences(SIMATS), Saveetha University, Chennai, India [email protected] [email protected] [email protected] ABSTRACT: The aim of the study was to estimate the prevalence of salivary gland diseases in patients visiting a private dental college. A retrospective analysis was conducted on patients who visited the Department of Oral Medicine from March 2019 to March 2020.Clinically diagnosed cases of salivary gland diseases which included salivary gland neoplasms, xerostomia, necrotizing sialometaplasia, mucocele, ranula, sjogren’s syndrome, sialodochitis, sialadenitis were included in the study.The details of each case were reviewed from an electronic database.From the study we found that 17 patients were diagnosed with salivary gland disease.The most commonly observed salivary gland disease was mucocele of the lip with a frequency of 41.17% in the study population followed by xerostomia (17.65%).Salivary gland disease can occur due to variable causes and might significantly affect the quality of life and daily functioning.Only with a thorough knowledge of the subject it is possible to detect the diseases of the salivary gland in their early stage and manage them more efficiently.
    [Show full text]
  • Sialolithiasis)
    J Clin Pathol: first published as 10.1136/jcp.41.4.403 on 1 April 1988. Downloaded from J Clin Pathol 1988;41:403-409 Clinicopathological study of myoepithelial sialadenitis and chronic sialadenitis (sialolithiasis) G M KONDRATOWICZ,* LESLEY A SMALLMAN, D W MORGANt From the *Department ofPathology, The Medical School, The University ofBirmingham, and tthe Department ofOtorhinolaryngology, The Queen Elizabeth Hospital, Birmingham SUMMARY To determine any overlap in pathological features between myoepithelial sialadenitis and chronic sialadenitis/sialolithiasis histological sections from 69 cases of myoepithelial sialadenitis (MESA) (n = 7) and chronic sialadenitis/sialolithiasis (n = 62) were reviewed over a 10 year period. Three of the cases with MESA contained calculi and four of those originally diagnosed as chronic sialadenitis/sialolithiasis showed epimyoepithelial island formation. The presence of calculi should not rule out a diagnosis of MESA, particularly in the parotid gland where calculi are uncommon; as the incidence of MESA may very well be underestimated and diagnosed as chronic sialadenitis, these patients, who are at increased risk of developing lymphoma, could be lost to follow up. Myoepithelial sialadenitis (MESA) is characterised by obtained from the files of the department of path- the formation of epimyoepithelial islands accompan- ology, University of Birmingham and the department ied by chronic lymphocytic infiltration of the salivary of histopathology, General Hospital, Birmingham. copyright. parenchyma and often glandular atrophy. It has Sections stained with haematoxylin and eosin were largely superceded the earlier used term, benign lym- reviewed and the presence or absence ofepimyoepith- phoepithelial lesion, which was coined by Godwin in elial islands, ductal infiltration by lymphoid cells, and 1952.12 calcified material noted.
    [Show full text]
  • A Guide to Salivary Gland Disorders the Salivary Glands May Be Affected by a Wide Range of Neoplastic and Inflammatory
    MedicineToday PEER REVIEWED ARTICLE CPD 1 POINT A guide to salivary gland disorders The salivary glands may be affected by a wide range of neoplastic and inflammatory disorders. This article reviews the common salivary gland disorders encountered in general practice. RON BOVA The salivary glands include the parotid glands, examination are often adequate to recognise and MB BS, MS, FRACS submandibular glands and sublingual glands differentiate many of these conditions. A wide (Figure 1). There are also hundreds of minor sali- array of benign and malignant neoplasms may also Dr Bova is an ENT, Head and vary glands located in the mucosa of the hard and affect the salivary glands and a neoplasia should Neck Surgeon, St Vincent’s soft palate, oral cavity, lips, tongue and oro - always be considered when assessing a salivary Hospital, Sydney, NSW. pharynx. The parotid gland lies in the preauricular gland mass. region and extends inferiorly over the angle of the mandible. The parotid duct courses anteriorly Inflammatory disorders from the parotid gland and enters the mouth Acute sialadenitis through the buccal mucosa adjacent to the second Acute inflammation of the salivary glands is usu- upper molar tooth. The submandibular gland lies ally of viral or bacterial origin. Mumps is the most in the submandibular triangle and its duct passes common causative viral illness, typically affecting anteriorly along the floor of the mouth to enter the parotid glands bilaterally. Children are most adjacent to the frenulum of the tongue. The sub- often affected, with peak incidence occurring at lingual glands are small glands that lie just beneath approximately 4 to 6 years of age.
    [Show full text]
  • Chronic Sclerosing Sialadenitis (Küttner's Tumour) of the Parotid Gland
    Case Report Chronic Sclerosing Sialadenitis (Küttner’s tumour) of the Parotid Gland Güçlü Kaan BERIAT1, Sefik HalitA KMANSU1, Sinan KOCATÜRK1, Ömür ATAOGLU2 Submitted: 4 Dec 2009 1 Department of Otolaryngology, Faculty of Medicine, Ufuk University, No:86, Accepted: 18 Mar 2010 Konya Avenue, 06520 Balgat, Ankara, Turkey 2 Department of Pathology, Faculty of Medicine, Gazi University, No:43, Konya Avenue, 06100 Bahçelievler, Ankara, Turkey Abstract Chronic sclerosing sialadenitis is a chronic inflammatory salivary gland disease. Küttner reported 4 cases of submandibular gland lesions for the first time in 1896. Chronic sclerosing sialadenitis is a very rare inflammatory lesion of the parotid gland and cannot be easily distinguished from salivary malignant masses. We reported a 28-year-old male with a painful parotid tumour, which grew slowly for 4 years. Keywords: chronic illness, inflammation, oral surgery, parotid gland, sclerosis, sialadenitis Introduction Case Report A series of patients with unilateral, hard, A 28-year-old male was investigated at tumour-like masses of the submandibular the Otolaryngology Outpatient Department. gland were diagnosed with chronic sclerosing He first noted the mass 4 years earlier. Physical sialadenitis by Küttner in 1896 (1). This disease is examination revealed a tender, hard and fixed, clinically similar to salivary gland neoplasms and 3 x 2 cm mass at the angle of the left maxillary is classified as a tumour-like lesion of the salivary arch, and it seemed to be attached to underlying glands by the World Health Organization (2). structures. No other masses or adenopathy were Chronic sclerosing sialadenitis is clinically noted in the head or neck.
    [Show full text]
  • Pathology of Head and Neck
    Pathology of Head and Neck • Pathology of Oral cavity • Pathology of Nose, and Nasopharynx • Pathology of Larynx • Pathology of Neck • Pathology of Salivary gland ผชู วยศาสตราจารย แพทยหญ งิ จลุ นทริ สําราญ Pathology of Oral cavity Inflammations and infections • Inflammations and infections • Herpes simplex virus infections • Reactive lesions • Aphthous ulcer ( Canker sores ) • Oral manifestations of systemic disease • Oral candidiasis ( Thrush ) • Glossitis • Tumors and precancerous lesions • Xerostomia Herpes simplex virus infections • Etiology ; HSV1 • Clinical feature ; – Acute herpetic gingivostomatitis in young children , severe diffuse involvement of the oral and pharyngeal mucosa, tongue and gingiva ,and spontaneously clear in 3-4 weeks 1 • Morphology – Recurrent herpetic stomatitis in young adult , milder – Gross ; Small vesicles to bullae painful, red- form involving lip, nasal orifices and buccal mucosa rimmed, shallow ulceration and spontaneously clear in 1-2 weeks – Histo ; Acantholysis and presence of intranuclear inclusion with multinucleated giant cells Aphthous ulcer ( Canker sores ) • Morphology ; – Gross ; single or multiple, shallow, hyperemic ulceration with red-rimmed and thin exudate covering – Histo ; mainly mononuclear cell infiltration and • Common superficial ulceration of oral mucosa neutrophilic infiltration when has secondary • Most in first decade of life bacterial infection • Clinical feature; painful and recurrent ulceration and clear within a week Oral candidiasis ( Thrush ) • The most common fungal infection
    [Show full text]
  • Oral Leukoplakia Treatment with the Carbon Dioxide Laser: a Systematic Review of the Literature
    Journal of Cranio-Maxillo-Facial Surgery xxx (2016) 1e6 Contents lists available at ScienceDirect Journal of Cranio-Maxillo-Facial Surgery journal homepage: www.jcmfs.com Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature Alfonso Mogedas-Vegara a, *, Juan-Antonio Hueto-Madrid a, Eduardo Chimenos-Küstner b, Coro Bescos-Atín a a Oral and Maxillofacial Department, Vall D'Hebron University Hospital, Universidad Autonoma de Barcelona, Passeig de la Vall D'Hebron 119-129, 08035 Barcelona, Spain b Oral Medicine, Oral Pathology, Oral Surgery Department, Universidad de Barcelona, Feixa Llarga s/n, L'Hospitalet Ll., 08907 Barcelona, Spain article info abstract Article history: We conducted a systematic review of the literature to evaluate treatment of oral leukoplakia with the Paper received 12 July 2015 carbon dioxide (CO2) laser. Accepted 27 January 2016 A comprehensive search of studies published between 1981 and 2015 and listed in the PubMed Available online xxx (National Library of Medicine, NCBI) database yielded 378 articles which were screened in detail. Rele- vant studies were selected according to predetermined inclusion and exclusion criteria. A total of 33 Keywords: articles met the final inclusion criteria and were analysed in detail in accordance with the PRISMA-P Systematic review statement. These full-text papers were classified as synopses (n 7), recurrence and malignant trans- Oral leukoplakia ¼ Carbon dioxide laser formation studies (n 17), comparative studies between CO2 laser and cold knife surgery (n 3) and ¼ fi ¼ Malignant transformation studies evaluating the ef cacy of CO2, Nd:YAG and KTP lasers. Potentially malignant oral disorder According to the literature the CO2 laser is the workhorse of oral leukoplakia treatment due to its Oral dysplasia effectiveness and low associated morbidity.
    [Show full text]
  • Differential Diagnosis of Igg4-Related Sialadenitis, Primary Sjögren
    Available online at www.sciencedirect.com ScienceDirect British Journal of Oral and Maxillofacial Surgery 55 (2017) 179–184 Differential diagnosis of IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis a,1 a,1 b b c c a a X. Hong , W. Li , X.-Y. Xie , Z.-Y. Zhang , Y. Chen , Y. Gao , X. Peng , J.-Z. Su , a a a a d d d d Y.-Y. Zhang , Z. Wang , Z.-G. Cai , L. Zhang , Y.-Y. Liu , J. He , L.-M. Ren , Z.-G. Li , a,∗ G.-Y. Yu a Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China b Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China c Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China d Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing 100044, China Accepted 25 October 2016 Available online 17 November 2016 Abstract Our aim was to differentiate IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis by analysing clinical, radiographic, and pathological features. Fifty-five patients, 50, and 50 were enrolled, respectively and their baseline characteristics and serological, sialographic, and pathological findings compared. The male:female ratio for IgG4-related sialadenitis was 1:1.2 for primary Sjögren syndrome 1:15.7, and for chronic obstructive submandibular sialadenitis1:0.92. Numbers with enlarged salivary glands were 55, 16, and 50; with xerostomia 26, 48, and 0; with a history of allergy 26, 4, and 6, and with coexisting systemic disease 12, 19, and 0 (p = 0.14).
    [Show full text]