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Research Into Digestive Diseases Digestive Into Research
01Research into Digestive Diseases RESEARCH PROGRESS SUMMARY: PI: Francis Chan, Jun Yu COLORECTAL CANCER (Department of Medicine A. Molecular Pathogenesis & Therapeutics, Institute of Digestive Diseases) 1. Single-cell whole-exome sequencing has been carried out to catalogue somatic mutations in 63 cancer cells isolated from a colon cancer Team: specimen. The mutation spectrum was heterogeneous at the single- Joseph Sung, Henry Chan, cell level. The accumulation of mutations was closely related to Justin Wu, Vincent Wong, tumorigenesis based on population genetic analysis. Among them, we Siew Ng identified a high-frequency mutated gene at the single-cell level, which Technical Report on Research Progammes Technical (Department of Medicine showed low prevalence in an additional cohort study of colon cancer. & Therapeutics, Institute of Functional characterisation of the mutant gene revealed its potential Digestive Diseases), oncogenic effect in colon cancer. Alfred Cheng, William Wu 2. Whole-exome sequencing of 10 colon cancer patients identified a (Institute of Digestive Diseases), novel recurrent mutation. This mutation was detected in 23 out of 118 Enders Ng, James Lau, Simon Ng, Philip Chiu patients (20.18%) in the validation cohort. Ectopic expression of this (Department of Surgery, mutant in colon cancer cells increased cell proliferation and colony- Institute of Digestive Diseases) forming ability, caused accumulation of cells in S-phase, and enhanced in vivo tumorigenicity. The mutant protein also exhibited altered subcellular localisation. 44 01 Research into Digestive Diseases 3. A bactericidal factor known as cathelicidin secreted 2. Multivariate analysis revealed that patients with YY1 by macrophages, polymorphonuclear leukocytes, protein high expression had a significant decrease in and colonocytes was reported to contribute to colon overall survival. -
OFFICIAL RECORD of PROCEEDINGS Thursday, 28 May 2015 the Council Met at a Quarter Past Nine O'clock
LEGISLATIVE COUNCIL ─ 28 May 2015 11963 OFFICIAL RECORD OF PROCEEDINGS Thursday, 28 May 2015 The Council met at a quarter past Nine o'clock MEMBERS PRESENT: THE PRESIDENT THE HONOURABLE JASPER TSANG YOK-SING, G.B.S., J.P. THE HONOURABLE ALBERT HO CHUN-YAN THE HONOURABLE LEE CHEUK-YAN THE HONOURABLE JAMES TO KUN-SUN THE HONOURABLE CHAN KAM-LAM, S.B.S., J.P. THE HONOURABLE LEUNG YIU-CHUNG THE HONOURABLE EMILY LAU WAI-HING, J.P. THE HONOURABLE TAM YIU-CHUNG, G.B.S., J.P. THE HONOURABLE ABRAHAM SHEK LAI-HIM, G.B.S., J.P. THE HONOURABLE TOMMY CHEUNG YU-YAN, S.B.S., J.P. THE HONOURABLE FREDERICK FUNG KIN-KEE, S.B.S., J.P. THE HONOURABLE WONG KWOK-HING, B.B.S., M.H. PROF THE HONOURABLE JOSEPH LEE KOK-LONG, S.B.S., J.P., Ph.D., R.N. 11964 LEGISLATIVE COUNCIL ─ 28 May 2015 THE HONOURABLE JEFFREY LAM KIN-FUNG, G.B.S., J.P. THE HONOURABLE ANDREW LEUNG KWAN-YUEN, G.B.S., J.P. THE HONOURABLE WONG TING-KWONG, S.B.S., J.P. THE HONOURABLE RONNY TONG KA-WAH, S.C. THE HONOURABLE CYD HO SAU-LAN, J.P. THE HONOURABLE STARRY LEE WAI-KING, J.P. DR THE HONOURABLE LAM TAI-FAI, S.B.S., J.P. THE HONOURABLE CHAN HAK-KAN, J.P. THE HONOURABLE CHAN KIN-POR, B.B.S., J.P. DR THE HONOURABLE PRISCILLA LEUNG MEI-FUN, S.B.S., J.P. THE HONOURABLE CHEUNG KWOK-CHE THE HONOURABLE WONG KWOK-KIN, S.B.S. -
Donor Appreciation
2018 Revenues Donor Appreciation We gratefully acknowledge the support of private contributors to the National 2018 Expenses Academy of Medicine. The collective, private philanthropy of our members and friends helps to enhance the NAM’s mission to lead, inspire innovation, and impact the health of all people. 51 2018 Donor Recognition In 2018, contributions from private donors helped the National Academy of Medicine provide expert advice to the nation, inspire bold ideas around the globe, and build leadership capacity for the future of health and health care. We are deeply grateful for the generous support. Every gift helps the NAM promote its core mission and respond to urgent priorities. Highlights from the year include: • $10.8 million in new commitments • $4.9 million for the Healthy Longevity Global Grand Challenge • $1.5 million for the Action Collaborative on Countering the U.S. Opioid Epidemic • 596 NAM members and friends contributed $535,120 to the Annual Fund • 29% of NAM members gave to the NAM or the Committee on Human Rights • New Einstein Society Members (cumulative giving of $100,000 or more) ▫ David Baltimore ▫ Barry and Bobbi Coller ▫ Jane Henney and Robert Graham. • New NAM Society Members (cumulative giving of $20,000) ▫ Mary and Dennis Bier ▫ Nathaniel E. David ▫ Norman and Deann Gant ▫ Sid Gilman and Carol Barbour ▫ James S. and Judith M. Marks ▫ Paul A. Offit ▫ Palmer and Susan Taylor ▫ David Walt and Michele May ▫ Myron and Linda Weisfeldt ▫ Keith R. Yamamoto Philanthropic gifts and grants make it possible for the NAM to fulfill its mission. We greatly appreciate all of the support received from our many members and friends. -
2018 Annual Report
出 Vision hi The Group is dedicated to its core value of res Exercising Caution in Details and 時 Implementation; Building a Strong Foundation to Seek Greater Success. 要 In strict compliance with the industry standard and dedicating to contribute to the industry, the Group will strive for growth and continuous innovation under China State’s principle of “Good Quality 轉 and Value Creation”. With the development of individual staff and strengths of teamwork, the Group will achieve a win-win situation with the shareholders, employees and society and become a new 用 role model in the new era. The Group will insist on developing into a leading corporation with competitive international complex B版 construction and infrastructure investment. 出 Contents 2 Corporate Structure 4 Board of Directors and Committees 5 Corporate Information 6 Financial Highlights 8 Major Events of the Year 2018 16 Chairman’s Statement 26 Management Discussion and Analysis 32 Business Review 46 Major Awards and Accolades 2018 48 Corporate Citizenship • Staff Development and Personal Growth • Environmental Policy • The Group and Community • Investor Relation 60 Directors and Organisation 67 Corporate Governance Report 79 Directors’ Report 87 Connected Transactions 97 Audited Consolidated Financial Statements • Independent Auditor’s Report • Consolidated Income Statement • Consolidated Statement of Comprehensive Income • Consolidated Statement of Financial Position • Consolidated Statement of Changes in Equity • Consolidated Statement of Cash Flows • Notes to the Consolidated -
Item for Finance Committee
For discussion FCR(2015-16)3 on 17 April 2015 ITEM FOR FINANCE COMMITTEE LOAN FUND NEW HEAD – “Private Hospital Development” New Subhead – “Loan for the CUHK Medical Centre Development Project” Members are invited to approve a commitment of $4,033 million for the provision of a loan to the CUHK Medical Centre Limited, a wholly-owned subsidiary of the Chinese University of Hong Kong, for the purpose of developing a non-profit making private teaching hospital, to be named the CUHK Medical Centre. PROBLEM The Chinese University of Hong Kong (CUHK), a statutory body incorporated under the Chinese University of Hong Kong Ordinance (Cap. 1109), requires the Government’s financial support in the form of a loan to implement the CUHK Medical Centre Development Project. PROPOSAL 2. The Secretary for Food and Health recommends the creation of a new commitment of $4,033 million, and the provision by the Government to the CUHK Medical Centre Limited, a wholly-owned subsidiary of CUHK, of a loan of $4,033 million under the Loan Fund. The proposed loan is to finance the development costs of a non-profit making private teaching hospital, to be named the CUHK Medical Centre, by CUHK and is for a period of 15 years with interest-free for the first five years from the first drawdown in 2016-17 and on a floating interest rate equivalent to the interest rate of the Government’s fiscal reserves placed with the Exchange Fund from 2021 onwards. /JUSTIFICATION ….. FCR(2015-16)3 Page 2 JUSTIFICATION The Development Proposal 3. -
WUN Presidents Forum 2015
WUN Presidents Forum 2015 ‘Global and Local: Reform Agendas for Higher Education in China and the World’ Thursday, 30 April 2015 The Chinese University of Hong Kong, Shenzhen [CUHK(SZ)] (Preliminary Programme as at 1 April 2015) Time Programme For delegates attending the WUN AGM – Coaches depart from the lobby of the Hyatt 7:15am Regency Sha Tin 9:15am – Arrival and registration 9:30am Opening Welcome by Professor Max Price, Chair of WUN Partnership Board & President, 9:30am – University of Cape Town (5 mins) 9.50am Welcome by Professor Xu Yangsheng, President, CUHK(SZ) (5 mins) Welcome by Dr. Xu Qin, Mayor of the Shenzhen Municipal Government (TBC) (5 mins) Group photo Keynote Address by Professor Yang Fujia, President, The University of Nottingham 9.50am – Ningbo China (20 mins) 10.20am Chinese Dream, Chinese Educational Dream First (中国梦,首先是中国教育梦) Discussion moderated by Professor Max Price & Professor Xu Yangsheng (10 mins) 10:20am – Morning tea 10.50am Panel Discussion Advancing higher education internationalization through partnership and collaboration Professor Joseph Sung, Vice-Chancellor & President, CUHK (Chair) Professor Martin Paul, President, Maastricht University (10 mins) 10.50am – Professor Xu Ningsheng, President, Fudan University (10 mins) 12:20pm Professor Stuart McCutcheon, Vice-Chancellor, The University of Auckland (10 mins) Professor Yonghua Song, Executive Vice-President, Zhejiang University (TBC) (10 mins) Open-floor discussion by all participants (30 mins) 12:20pm- Closing remarks by Professor John Hearn, Executive Director, WUN 12:30pm 12:30pm – Coach transfer to lunch venue 12:40pm 12:40pm – Lunch at Castle Hotel of Genzon 1:40pm 1:40pm – End of programme. -
A Day in the Life of the Vice-Chancellor
A Day in the Life of the Vice-Chancellor rofessor Joseph J.Y. Sung has been Vice-Chancellor of CUHK for several months, and so far, a hectic schedule is the norm rather Pthan the exception. One day in November 2010, he treated patients, taught students, gave lectures, received University guests, officiated at a ceremony, and attended a student gathering. From dawn to dusk, he shifted between his many roles, but always with zeal and composure. 8:15 am. The Vice-Chancellor cast a towering shadow at the entrance to the CUHK-PWH Medical Centre in the morning light, his doctor’s coat a reminder of the role by which Hong Kong first knew him. He had not just arrived. He had been at the Prince of Wales Hospital since 7:30 am for a meeting. He was scheduled to see patients at the medical centre, something he said he would continue to do before taking up the vice-chancellorship. ‘Good morning, Vice-Chancellor. How are you? You seem so much busier than when you were a professor. Thanks for making time to see me.’—A typical greeting as such is a valid proof of patients’ awareness of the many hats the doctor is wearing. Two Year 5 medical students joined Sung at the clinic. He spoke to the patient in Cantonese and explained the condition to the students in English. At one point, he spent eight minutes explaining the pros and cons of two drugs, as well as the correct dosage and the criteria for choosing one over the other. -
Academic Freedom in Hong Kong Since 2015: Between Two Systems
Academic Freedom in Hong Kong since 2015: Between Two Systems Kevin Carrico January 2018 Hong Kong Watch Academic Freedom in Hong Kong 1 EXECUTIVE SUMMARY The state of academic freedom in Hong Kong is a microcosm of the state of “one country, two systems” as a whole. It is alive, and generally well, but only due to constant public vigilance against growing threats. Hong Kong’s students and scholars played a central role in the 2014 Occupy protests for political reform. As a result, since early 2015, a growing top-down backlash has attempted to limit academic freedom and bring academia under the authorities’ control. This post-Occupy retribution is manifested in the following trends: • Controversial academic figures have been removed from their posts, seen promotions blocked, or faced extra-legal campaigns to pressure their removal. These were all driven by political motivations. • State-appointed and politically connected figures have governed universities in a manner divorced from the will of students and faculty. • There is a growing push to place limits on freedom of speech, without any legal basis. Although academic work in Hong Kong remains considerably freer than in the rest of the People’s Republic of China, these trends suggest that elements of academic control in place elsewhere in China are gradually being incorporated into the Hong Kong system, threatening the city’s academic freedom and thus its universities’ reputations. POLICY RECOMMENDATIONS • Educators must directly and openly confront “taboo” topics in Hong Kong, or run the risk of enabling a censorship regime that will continually expand, swallowing up new topics as forbidden. -
Family Physicians Links Represent Personal View Only and Are Not Necessarily Shared by the College Or the Publishers
THE HONG KONG Message from the President COLLEGE OF FAMILY PHYSICIANS Hong Kong Primary Care Conference 2013 Our Hong Kong Primary Care Conference (HKPCC), “Innovations in Primary Care” will be held on June 16, 2013 at the Hong Kong Academy of Medicine Jockey Club Building, 99 Wong Chuk Hang Road, Aberdeen, Hong Kong. This year we will be having a full day of exciting scientific programme. Following Family the success of our first clinical case presentation competition last year, we will be holding this competition again this year. Do not miss this educational and entertaining session with competitor teams presenting clinical cases in different formats. Their presentations are often interesting! Physicians After the opening ceremony we will have the first plenary session “Driving Innovations in Primary Care Research” by Prof. Doris Young. Prof. Young is the Chair of General Practice, and Associate Dean (Academic), Faculty of Medicine, the University of Melbourne. She is also our Honorary Fellow and has been our external Exit Examiner since 2007. Her dedication to and advice on primary care Links research and development have always been insightful for our development. Family Our second plenary session is “Primary Care Models - Let a Hundred Flowers Bloom” by Prof. Gabriel Leung. Prof. Leung is the Head of the Department of Physicians Community Medicine, the University of Hong Kong after serving as Hong Kong's first Under Secretary for Food and Health and the fifth Director of the Chief Executive's Office. He will discuss not only the various primary care models, Links but also how they should be allowed to experiment, and be evaluated and implemented. -
CURRICULUM VITAE Lixing Lao, Phd, MB, L.Ac. President
CURRICULUM VITAE Lixing Lao, PhD, MB, L.Ac. President Virginia University of Integrative Medicine 9401 Mathy Drive, Fairfax, VA 22031 Website: https://www.vuim.edu Tel: (703) 323 5690 ext. 108 Fax: (703) 323 5692 Email: [email protected] Cellphone: (703) 501 8833 EDUCATION 1978 – 1983 M.B. Traditional Chinese Medicine and Acupuncture, Shanghai University of Traditional Chinese Medicine, Shanghai, China 1987 – 1992 Ph.D. Physiology, University of Maryland at Baltimore, Baltimore, Maryland Post Graduate Training 1982 – 1983 Internship: Shanghai University of Traditional Chinese Medicine, Shanghai, China 1983 – 1986 Residency: Shanghai University of Traditional Chinese Medicine, Shu-Guang Hospital, Shanghai, China CERTIFICATIONS 1990 – Present Diplomat in Acupuncture, National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM) Provider #: ACHB426-097 (NCCAOM ID: 2286) 1998 – Present Diplomat in Chinese Herbology, National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM) Provider #: ACHB426-097 (NCCAOM ID: 2286) 2005 – Present Diplomat in Oriental Medicine, National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM), Provider #: ACHB426-097 (NCCAOM ID: 2286) ACUPUNCTURE LICENSURES 1988.3.21 – Present Maryland Board of Acupuncture U-00300 (Exp. 11/30/2021) 2013.9 – 2019.10 Hong Kong, Limited registration for Chinese Medicine Practice (LR0708) 2019.12.4-Present Virginia Board of Medicine, Licensed Acupuncturist (# 0121000955) (Exp. 06/30/2021) PROFESSIONAL EXPERIENCE AND EMPLOYMENT 1983-1986 Teaching Faculty, Department of Acupuncture, Shanghai College of Traditional Chinese Medicine, Shanghai, P. R. China. 1988-1992 Graduate Research Assistant, Department of Physiology, Dental School, University of Maryland at Baltimore, MD. 1992 Research Associate, Department of Anesthesiology, University of Maryland at Baltimore 1992-2002 Teaching Faculty (part-time), Maryland Institute of Traditional Chinese Medicine. -
Digestive Diseases 063 LI KA SHING INSTITUTE of HEALTH SCIENCES PROGRESS REPORT 2016
Appendix: Digestive Diseases 063 LI KA SHING INSTITUTE OF HEALTH SCIENCES PROGRESS REPORT 2016 01 Research Progress Summary DIGESTIVE DISEASES A. Molecular pathogenesis 1. Using a genome-wide shRNA screen in colorectal cancer (CRC) cells with mutations in APC and KRAS, the team identified a novel oncogenic candidate SLC25A22. SLC25A22 plays an important role in tumour metabolism in KRAS-mutant CRC by promoting biosynthesis of the nonessential amino acid aspartate. SLC25A22 protein and mRNA levels were independent prognostic markers associated with poor survival in KRAS-mutant CRC patients. 2. Whole genome sequencing has identified solute carrier family 12 member 5 (SLC12A5) as a novel amplification gene in colorectal cancer. SLC12A5 possessed oncogenic properties by promoting tumour proliferation and metastasis, and inhibiting cell apoptosis. SLC12A5 protein overexpression was found to be an independent prognostic factor associated with shortened survival in colorectal cancer patients. 3. Using methylated DNA immunoprecipitation array, the team identified Carbonic Anhydrase 4 (CA4) as a novel tumour suppressor gene silenced in colorectal cancer through promoter methylation. CA4 inhibited Wnt signalling pathway via WTAP–WT1–TBL1 axis, thereby suppressing colorectal cancer development. The team also found that methylation status of CA4 may serve as an independent biomarker for the recurrence of CRC. 4. Sequencing of fimH gene of Escherichia coli (E. coli) leads to the identification of α-hemolysin-positive (hly+) type 1 E.coli that contributes to adenomagenesis and CRC in human females. Hly+ type 1-E. coli were more prevalent in stools from females with adenoma and CRC and their abundance was correlated with poor survival. Feeding hly+ type 1-E. -
Hong Kong Academy of Medicine
HONG KONG ACADEMY OF MEDICINE Recognized Training Units in Hong Kong College Training Units Accreditation Expiry Community Medicine I. Jockey Club School of Public Health and Primary 30 June 2022 Care, CUHK (for Public Health Medicine, Occupational and Environmental Medicine, and Administrative Medicine) II. School of Public Health, HKU 30 June 2022 (for Public Health Medicine) III. HKU Health System, HKU 30 June 2022 (for Administrative Medicine) IV. Department of Health, Hong Kong 30 June 2022 ( for Public Health Medicine and Administrative Medicine) V. Food & Environmental Hygiene Department 30 June 2022 (for Public Health Medicine) VI. Hospital Authority Head Office and 7 Clusters 30 June 2022 (for Administrative Medicine) VII. Occupational Health Service, Labour Department 30 June 2022 (for Occupational and Environmental Medicine) VIII. Hospital Authority (7 Clusters) 30 June 2022 (Occupational Medicine Service for Occupational and Environmental Medicine) Training activities will take place in locations controlled by these training units. Such locations include: For CUHK 1 Jockey Club School of Public Health and Primary Care 2 CUHK Medical Centre Planning Office For HKU 1 School of Public Health 2 HKU Health System For Department of Health 1 Headquarters 2 CHP Communicable Disease Branch 3 CHP Emergency Response & Programme Management Branch 4 CHP Health Promotion Branch 5 CHP Infection Control Branch 6 CHP Non-Communicable Disease Branch 7 CHP Public Health Services Branch (Social Hygiene Service, Special Preventive Programme, Tuberculosis