Author Manuscript Published OnlineFirst on May 21, 2019; DOI: 10.1158/1055-9965.EPI-18-1111 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Title: Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases Rashid NS Lui1, Kelvin KF Tsoi2,3, Jason MW Ho3, CM Lo3, Felix CH Chan3, Moe H Kyaw1,4, Joseph JY Sung1,4 1. Department of Medicine and Therapeutics, CUHK 2. Jockey Club School of Public Health and Primary Care, CUHK 3. Stanley Ho Big Data Decision Analytics Research Centre, CUHK 4. Institute of Digestive Disease, CUHK The Chinese University of Hong Kong Author list: Rashid N LUI Kelvin KF TSOI Jason MW HO CM LO Felix CH CHAN Moe H KYAW Joseph JY SUNG Corresponding Author: Joseph SUNG MD, PhD Institute of Digestive Disease The Chinese University of Hong Kong Prince of Wales Hospital Shatin, Hong Kong
[email protected] (852) 3505 3174 Running title: Young-onset colorectal cancer incidence is rising globally Keywords: colorectal cancer, neoplasia, epidemiology, young-onset The authors declare no potential conflicts of interest 1 Downloaded from cebp.aacrjournals.org on October 1, 2021. © 2019 American Association for Cancer Research. Author Manuscript Published OnlineFirst on May 21, 2019; DOI: 10.1158/1055-9965.EPI-18-1111 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Background: Colorectal cancer (CRC) incidence among young adults in the United States (US) is on the rise, but whether this phenomenon is present in other parts of the world is not well documented.