Annex 2 Composition of Oral and Injectable Estrogen–Progestogen Contraceptives
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ANNEX 2 COMPOSITION OF ORAL AND INJECTABLE ESTROGEN–PROGESTOGEN CONTRACEPTIVES Annex 2 lists the composition of brands of estrogen–progestogen preparations used in combined injectables (Table 1), combined oral (Table 2) and phasic oral (Table 3) contraceptives. The countries in which these formulations are used are noted. Are listed only those brands for which availability was reported. The source of these tables is the International Planned Parenthood Foundation (IPPF). Data have been taken from the IPPF 2002 website [http://contraceptive.ippf.org] at the time of the monograph meeting (June 2005). This online site is regularly updated. Table 1. Combined injectables Brand name Composition Countries of availability Acefil Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Agurin Dihydroxyprogesterone acetophenide 150 mg Chile + estradiol enanthate 10 mg Anafertin Dihydroxyprogesterone acetophenide 75 mg El Salvador, Mexico + estradiol enanthate 5 mg Ciclofem Medroxyprogesterone acetate 25 mg Guatemala + estradiol cypionate 5 mg Ciclofemina Medroxyprogesterone acetate 25 mg El Salvador + estradiol cypionate 5 mg Ciclomes Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Ciclovular Dihydroxyprogesterone acetophenide 150 mg Brazil + estradiol enanthate 10 mg Clinomin Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Cyclofem Medroxyprogesterone acetate 25 mg Chile, Indonesia, Malaysia, Mexico, + estradiol cypionate 5 mg Panama, Zimbabwe Cyclofemina Medroxyprogesterone acetate 25 mg Brazil, Costa Rica, Mexico + estradiol cypionate 5 mg Cycloven Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg –431– 432 IARC MONOGRAPHS VOLUME 91 Table 1 (contd) Brand name Composition Countries of availability Deproxone Dihydroxyprogesterone acetophenide 150 mg Dominican Republic, El Salvador, + estradiol enanthate 10 mg Honduras, Panama Ginestest Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Gynomes Dihydroxyprogesterone acetophenide 150 mg El Salvador + estradiol enanthate 10 mg Listen Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Lunelle Medroxyprogesterone acetate 25 mg Puerto Rico, USA + estradiol cypionate 5 mg Mesigyna Norethisterone enanthate 50 mg Argentina, Bahamas, Barbados, + estradiol valerate 5 mg Bolivia, Brazil, Chile, Colombia, Dominican Republic, Ecuador, Egypt, El Salvador, Ghana, Grenada, Guatemala, Guyana, Honduras, Jamaica, Mexico, Nicaragua, Panama, Paraguay, Peru, St. Lucia, Turkey, Uruguay, Venezuela Neogestar Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Norigynon Norethisterone enanthate 50 mg Ghana, Kenya, Zimbabwe + estradiol valerate 5 mg Normagest Dihydroxyprogesterone acetophenide 150 mg El Salvador, Honduras, Nicaragua, + estradiol enanthate 10 mg Panama Novafem Medroxyprogesterone acetate 25 mg Chile + estradiol cypionate 5 mg Novular Dihydroxyprogesterone acetophenide 150 mg El Salvador + estradiol enanthate 10 mg Oterol Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Ovoginal Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Perlutal Dihydroxyprogesterone acetophenide 150 mg Argentina, Belize, Mexico, Peru + estradiol enanthate 10 mg Perlutan Dihydroxyprogesterone acetophenide 150 mg Brazil + estradiol enanthate 10 mg Perlutin- Dihydroxyprogesterone acetophenide 150 mg Paraguay Unifarma + estradiol enanthate 10 mg Permisil Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg ANNEX 2 433 Table 1 (contd) Brand name Composition Countries of availability Proter Dihydroxyprogesterone acetophenide 150 mg Costa Rica + estradiol enanthate 10 mg Seguralmes Dihydroxyprogesterone acetophenide 150 mg Chile + estradiol enanthate 10 mg Soluna Dihydroxyprogesterone acetophenide 150 mg Peru + estradiol benzoate 10 mg Topasel Dihydroxyprogesterone acetophenide 150 mg Costa Rica, Dominican Republic, + estradiol enanthate 10 mg Ecuador, El Salvador, Honduras, Nicaragua, Panama, Spain Unigalen Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Uno Ciclo Dihydroxyprogesterone acetophenide 150 mg Brazil + estradiol enanthate 10 mg Vagital Dihydroxyprogesterone acetophenide 150 mg Paraguay + estradiol enanthate 10 mg Yectames Dihydroxyprogesterone acetophenide 75 mg Costa Rica, Dominican Republic, + estradiol enanthate 5 mg El Salvador, Honduras, Mexico, Panama Yectuna Dihydroxyprogesterone acetophenide 120 mg Paraguay + estradiol enanthate 10 mg From IPPF (2002) Table 2. Combined pills Brand name Composition Countries of availability Alesse Levonorgestrel 0.1 mg Canada, USA + ethinylestradiol 20 μg Anfertil Levonorgestrel 0.25 mg Brazil + ethinylestradiol 50 μg Anna Levonorgestrel 0.15 mg Cambodia, Laos, Myanmar, Thailand, Viet + ethinylestradiol 30 μg Nam Anovlar 1mg Norethisterone acetate 1 mg Egypt, Iraq, Morocco + ethinylestradiol 50 μg Anovulatorios Levonorgestrel 0.15 mg Chile Microdosis + ethinylestradiol 30 μg Anuar Cyproterone acetate 2 mg Chile + ethinylestradiol 35 μg Anulette 20 Levonorgestrel 0.1 mg Chile + ethinylestradiol 20 μg 434 IARC MONOGRAPHS VOLUME 91 Table 2. Combined pills Brand name Composition Countries of availability Anulette C.D. Levonorgestrel 0.15 mg Chile + ethinylestradiol 30 μg Anulette Levonorgestrel 0.15 mg Chile, Peru + ethinylestradiol 30 μg Anulit Levonorgestrel 0.15 mg Paraguay + ethinylestradiol 30 μg April Levonorgestrel 0.1 mg Uruguay + ethinylestradiol 20 μg Belara Chlormadinone acetate 2 mg Ecuador, Germany + ethinylestradiol 30 μg Brenda 35 Cyproterone acetate 2 mg Australia + ethinylestradiol 35 μg Brevicon Norethisterone 0.5 mg Puerto Rico, St. Lucia, USA + ethinylestradiol 35 μg Brevicon 0.5 + 35 Norethisterone 0.5 mg Canada + ethinylestradiol 35 μg Brevicon 1+35 Norethisterone 1 mg Canada + ethinylestradiol 35 μg Brevicon 20 Norethisterone 0.5 mg Mexico + ethinylestradiol 35 μg Brevinor Norethisterone 0.5 mg Australia, Hong Kong, Ireland, Malaysia, + ethinylestradiol 35 μg Malta, Mauritius, New Zealand, South Africa, Sudan, United Kingdom Brevinor-1 Norethisterone 1 mg Australia + ethinylestradiol 35 μg Ciclidon Desogestrel 0.15 mg Chile + ethinylestradiol 30 μg Ciclidon 20 Desogestrel 0.15 mg Chile + ethinylestradiol 20 μg Ciclo 21 Levonorgestrel 0.15 mg Brazil + ethinylestradiol 30 μg Ciclomex Gestodene 0.075 mg Chile + ethinylestradiol 30 μg Ciclomex 20 Gestodene 0.075 mg Chile + ethinylestradiol 20 μg Ciclon Levonorgestrel 0.15 mg Brazil + ethinylestradiol 30 μg ANNEX 2 435 Table 2 (contd) Brand name Composition Countries of availability Cilest Norgestimate 0.25 mg + Argentina, Armenia, Aruba, Austria, ethinylestradiol 35 μg Barbados, Belgium, Bermuda, Bolivia, Bulgaria, Colombia, Costa Rica, Cyprus, Czech Republic, Denmark, Dominican Republic, Egypt, El Salvador, Estonia, Finland, France, Germany, Guatemala, Honduras, Hungary, Ireland, Israel, Italy, Jamaica, Kuwait, Latvia, Lithuania, Luxembourg, Macedonia, Mexico, Netherlands, Netherlands Antilles, Nicaragua, Norway, Panama, Paraguay, Poland, Qatar, Romania, Russia, Slovak Republic, Slovenia, Spain, Sudan, Sweden, Switzerland, Trinidad and Tobago, United Arab Emirates, United Kingdom, Uruguay, Yugoslavia Conceplan M Norethisterone 0.5 mg Germany + ethinylestradiol 30 μg Confiance Levonorgestrel 0.15 mg Côte D’Ivoire + ethinylestradiol 30 μg Conova Ethynodiol diacetate 2 mg Bermuda + ethinylestradiol 30 μg Conova 30 Ethynodiol diacetate 2 mg Belgium, Luxembourg, Malawi, St. Vincent + ethinylestradiol 30 μg and the Grenadines, Tanzania, Trinidad and Tobago Cycleane 30 Desogestrel 0.15 mg Djibouti, France + ethinylestradiol 30 μg Cycleane-20 Desogestrel 0.15 mg France + ethinylestradiol 20 μg Demulen Ethynodiol diacetate 1 mg Russia, Trinidad and Tobago + ethinylestradiol 50 μg Demulen 1/35 Ethynodiol diacetate 1 mg Jamaica, Netherlands Antilles, Puerto Rico, + ethinylestradiol 35 μg USA Demulen 1/50 Ethynodiol diacetate 1 mg Russia, USA + ethinylestradiol 50 μg Demulen 30 Ethynodiol diacetate 2 mg Canada, Puerto Rico + ethinylestradiol 30 μg Denoval Levonorgestrel 0.25 mg Belize, Dominican Republic, El Salvador, + ethinylestradiol 50 μg Guatemala, Honduras, Nicaragua Denoval-Wyeth Levonorgestrel 0.25 mg Costa Rica + ethinylestradiol 50 μg Desmin 20 Desogestrel 0.15 mg Germany + ethinylestradiol 20 μg 436 IARC MONOGRAPHS VOLUME 91 Table 2 (contd) Brand name Composition Countries of availability Desmin 30 Desogestrel 0.15 mg Germany + ethinylestradiol 30 μg Desogen Desogestrel 0.15 mg USA + ethinylestradiol 30 μg Desolett Desogestrel 0.15 mg Sweden, Turkey + ethinylestradiol 30 μg Desoran Desogestrel 0.15 mg Chile + ethinylestradiol 30 μg Desorelle Desogestrel 0.15 mg Denmark, Romania + ethinylestradiol 30 μg Desoren 20 Desogestrel 0.15 mg Chile + ethinylestradiol 20 μg Diane Cyproterone acetate 2 mg Albania, Armenia, Australia, Azerbaijan, + ethinylestradiol 35 μg Bahrain, Barbados, Belarus, Belgium, Bermuda, Brazil, Bulgaria, Canada, Colombia, Croatia, Cyprus, Czech Republic, Egypt, France, Georgia, Germany, Hungary, Ireland, Israel, Italy, Jordan, Kazakhstan, Kenya, Kuwait, Kyrgyzstan, Lebanon, Luxembourg, Macedonia, Malawi, Malaysia, Malta, Mauritius, Mexico, Moldova, Morocco, Netherlands, New Zealand, Nigeria, Norway, Oman, Pakistan, Peru, Philippines, Poland, Portugal, Qatar, Romania, Russia, Saudi Arabia, Singapore, Slovak Republic, Slovenia, South Africa, Spain, Sri Lanka, St. Lucia, Sweden, Switzerland,