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APPENDIX 8 Progress Report on the EUFMD Supported Actions in FMD

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APPENDIX 8 Progress Report on the EUFMD Supported Actions in FMD APPENDIX 8 Progress report on the EUFMD supported actions in FMD Control in the Republic of Azerbaijan Leos Celeda, Chairman EUFMD I. Introduction The mission was undertaken as part of the FAO-EUFMD planned mission programme and represents the third FAO-EUFMD/OIE/ARRIAH mission to the countries of the Trans-Caucasus. This report refers to the first visit to the Republic of Azerbaijan, 16- 28 March 2003. It was preceded by a visit to ARRIAH, Vladimir to discuss the proposed programme and surveillance support to be conducted under the Letter of Agreement with FAO. II. Objectives of the mission • Prioritise vaccination activities in the buffer zone on basis of risk. • Organize and inspect the FMD vaccination activities in the buffer zone. • Identify high, medium and low risk areas for FMD surveillance and control. • Review contingency plans and preparedness to FMD outbreak control. • Identify constraints and opportunities in the surveillance system for FMD. • Plan sero-surveillance activities (with ARRIAH). III. Background of the mission The third mission (the first in 1999, the second one in 2000) is part of action taken by FAO Working Programme in Caucasus Region in the year 2003, based on the recommendations of the Tripartite Meeting, held on 7 February 2002 in Rome, which were discussed further during the 70th OIE General Session in Paris and followed by the meeting at the OIE Headquarters in Paris on 5 November 2002. During the 68th Session of the Executive Committee of the EUFMD (7-8 November 2002) it was also recommended that consideration of longer-term FMD control programmes should depend on the progress of the short-term activities in the first half of 2003. In order to support the short-term project, the European Commission adopted Decision of 5 December 2002 on a Community financial contribution to emergency measures to control foot-and-mouth disease in Armenia, Azerbaijan and Georgia and amending Decision 2001/300/EC. The Trust Fund 911100/MTF/INT/003/EEC was used to cover following measures: a) To purchase 1 000 000 doses of aluminium hydroxide adjuvanted trivalent vaccine against the foot-and–mouth disease virus of types O1, A-Iran 96 and ASIA-1 with potency of 6 PD50. 96 b) The delivery of vaccine to the central veterinary authorities of Armenia, Azerbaijan and Georgia for emergency vaccination in the districts along their southern borders in accordance with the vaccination programme to be set up. c) On-the-spot supervision of vaccination campaign and organisation of serological surveillance. d) The supply of test kits for the detection of antibodies against NSP, the monitoring of the vaccination campaign and the substantiation of the disease situation. IV. Azerbaijan-National FMD vaccination programme in 2002: There were 2 276 537 cattle vaccinated (trivalent vaccine) and 576 879 sheep (bivalent A,O) around the whole country last year. Booster campaign was organized in seven districts close to Georgia last autumn. V. Programme implementation- 2003 Buffer Zone Vaccination and sero-surveillance plan, Spring 2003: The trivalent vaccine used in the project consists of following strains: O1 (isolated in Georgia, 2000), A (Armenia 98) and Asia-1 (Georgia, 2001). Nucleotides sequences diagrams are available in part four (annexes). The O and A antigen are produced routinely whereas Asia-1 strain was prepared for this vaccines batch. Aziridine was used for inactivation. The protective doses were determined as follows: O-8 PD50 at least, A-10,5 PD50 at least and Asia 1 – 6 PD50 at least. Vaccines were filled into glass bottles (150 ml, 50 doses for cattle) and labelled as requested in the contract. The vaccine stock for the project was delivered from Moscow on 27–28 February 2003 and shipped by two consignments (by air via Istanbul). The shipment was inspected on the spot by the Netherlands Superintending and Sampling Company on 12 March 2003 and an audit report was prepared. The Gosvetsnab organization is responsible for vaccines and veterinary medicines supply in the country. All vaccines to be used for prophylactic measures are kept here and distributed as needed; there are two cold rooms available, which were rebuilt recently at the former Veterinary Institute facilities. The inside temperature records are kept. Vaccine delivery around the country is by means of three cars equipped with cooled cabins. Three hundred thermo-boxes were obtained recently and are in use at district Veterinary Offices. After mutual discussion and exchange of views with the staff from the Department of epizootology, the following plans were agreed for buffer zone creation, and selection of districts where samples will be collected – see following tables and maps in annexes. Vaccine distribution started immediately after our visit. The stock was delivered according to the prepared plan agreed and signed by the Minister of Agriculture. 97 LIVESTOCK POPULATION AND VACCINE DISTRIBUTION (FAO/OIE/EC PROJECT) Doses of vaccine District Large ruminants Small ruminants received (Cattle) Nakhichevan A.R. 79.108 461.655 24.000 Fizuli 14.478 50.906 14.400 Beilagan 38.807 213.575 38.400 Imishli 60.591 186.047 62.100 Bilasuvar 34.761 106.647 36.300 Djalilabad 96.209 118.683 100.400 Yardimli 21.799 60.297 22.700 TOTAL 345.753 1.197.810 298.300 LIVESTOCK POPULATION AND VACCINE DISTRIBUTION (NATIONAL PROJECT) Doses of vaccine District Large ruminants Small ruminants received (Cattle) Astara 27/147 14.096 27.800 Lerik 34.648 124.675 35.500 T O T A L 61.795 138.771 63.300 SERO-SURVEILLANCE MONITORING PLAN (SPRING – SUMMER 2003) District Proposed sample size Status Astara 200 Vaccinated – nat. prog. Djalilabad 200 Vaccinated – project Imishli 200 Vaccinated – project Nakhichevan A.R 100 Vac.project + nat. prog. Zaqatala 200 Outbreak in 2001 Apsheron 200 Declared as free Plan for assessing vaccination efficacy in the Republic of Azerbaijan, and diagnostic procedures in the case of suspected FMD The following document was prepared and agreed by all participating parties. 1. Within the framework of joint FAO/OIE/EC programme altogether 300.000 doses of FMD vaccine (A, O, Asia-1) produced by ARRIAH (Russian Federation, Vladimir) have been delivered to the Republic of Azerbaijan. 98 Vaccines were distributed to seven districts of the Republic of Azerbaijan according to the provisions on 17.03.2003 (see above). Vaccination campaign is foreseen to start in designated districts on 18. 03. 2003, large ruminants will be vaccinated in size based on census results of 01.01.2003. In order to assess the vaccination efficacy and vaccine immunogenity in field conditions it is planned: - to perform twice repeated blood collection in 7 districts of the country within an interval of 2 to 3 months; - the first sampling is foreseen from 30 to 45 days after vaccination; - Re-sampling within 90 – 100 days, laboratory tests will be performed at ARRIAH (Russian Federation, Vladimir); - At the same time ARRIAH experts will organize a training course for the Republican Veterinary Laboratory (Azerbaijan, Baku) staff on ELISA methods for FMD typing and FMD antibodies detection in blood samples. 2. In the case of FMD suspicion in the Republic of Azerbaijan and pathological materials delivery to the ARRIAH in order to perform virus typing and molecular studies, the ARRIAH is obligated to cover related travel expenses to college from the Azerbaijan Veterinary Services, who will bring samples to Vladimir. Agreed : Dr. SAFAROV, Dr.CELEDA, Dr.DUDNIKOV Republican Veterinary Laboratory The main laboratory building is being reconstructed. The water and energy supply was restored last year and some other repairs are in progress. General discussion on main laboratory tasks was held. Tests are mainly oriented to the cattle and poultry diseases and to the control of imported food. One reconstructed laboratory room was presented, but equipment seemed not to be routinely used. There is no trained staff for FMD diagnosis available and ELISA methods are generally not applied. Possibilities of staff training in this respect during the first sampling period was discussed and offered. Staff recruitment and its stabilization including appropriate training in FMD diagnostic procedures (not only) is of crucial importance. Field visits Visits to inspect and audit the vaccination in the buffer zone took place to Bilasuvar, (South – East of the country), to Djalilabad, to Lankaran District Veterinary Office, and to Imishli district. The latter area was selected in order to audit vaccination campaign in this area close to the Iranian border. Conclusion from field visits Based on the national prophylactic plan, there is a vaccination procedure against anthrax scheduled usually at the beginning of each year (end of January – February). Blood samples for brucellosis detection in cattle are collected at the same time. FMD 99 prophylaxis was planned 14 days thereafter. As animal movements to the pasture are starting at the end of March and cold chain regimen for vaccine storage might be still problem in final stage of its distribution, it is desirable to keep vaccine stocks on the spot at the end of February latest. Unusually cold climate this year is an advantage in this respect. A majority of herds are moved depending on pasture availability during the whole season. The animal movement is out of veterinary control except for the situation during epizootic periods when restrictive measures could be imposed by legal basis. CONCLUSIONS AND RECOMMENDATIONS 1. VACCINATION The concept of FMD buffer zone creation and its maintenance along the southern borders (with Turkey and Iran) in Caucasian countries is desirable. However, taking into account all related difficulties and huge live animals and animal products movement in the region it is advisable to create and keep all internal control measures including preventative vaccination of susceptible animals along the main trade flows areas in the Republic of Azerbaijan.
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