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Chu Chen, MS, Phd, NRCC, DABCC Full Professor Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Mail Stop M5-C800 P.O

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Chu Chen, MS, Phd, NRCC, DABCC Full Professor Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Mail Stop M5-C800 P.O CHU CHEN, MS, PhD, NRCC, DABCC PERSONAL DATA Address: Chu Chen, MS, PhD, NRCC, DABCC Full Professor Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Mail Stop M5-C800 P.O. Box 19024 Seattle, Washington 98109-1024 Tel: (206) 667–6644 Fax: (206) 667–2537 E–mail: [email protected] Ctizenship: USA Gender: Female EDUCATION 2003 Fifth Annual Seattle Epidemiology & Biostatistics Summer Section at University of Washington, sponsored by Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs, and Department of Epidemiology and Department of Biostatistics, University of Washington. 2000 New England Epidemiology Institute Summer Course, Tufts University. 1990-1992 Senior Fellow, Division of Clinical Chemistry, Department of Laboratory Medicine, University of Washington, Seattle, Washington. Second Year Specialty Training: Clinical Toxicology. 1987-1990 Postdoctoral Research Associate, Laboratory of Maxine Linial, Ph.D., Professor, Program in Viral Oncology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1983-1986 Individual National Research Service Award Postdoctoral Fellow, Laboratory of Sen–itiroh Hakomori, M.D., Ph.D., Professor, Program in Biochemical Oncology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington and Professor, Department of Pathobiology, University of Washington. 1982 Ph.D. in Biochemistry, University of Washington, Seattle, Washington. Dissertation: "Structure and Reactivity of the Small Spherical High Density Lipoproteins in Familial Lecithin: Cholesterol Acyltransferase Deficiency as Compared with the Structure and Reactivity of Artificially Formed Lipoproteins." Dissertation Advisor: John A. Glomset, M.D., PhD., Professor, Department of Biochemistry and Investigator, Howard Hughes Medical Institute, University of Washington. 1971 M.S. in Botany, Specialization: Medical Mycology, Ohio State University, Columbus, Ohio. Thesis: "The Effect of Chlorination on the Survival of Candida albicans (strains #8314, 8329, 8335, 8282)." Thesis Advisor: John A. Schmidt, Ph.D. 1968 B.S. in Botany, National Taiwan University, Taipei, Taiwan, Republic of China. PROFESSIONAL POSITIONS Chu Chen Page 1 of 64 2017-present Member, Pathogen-Associated Malignancy Integrated Research Center, Fred Hutchinson Cancer Research Center 2006-present Affiliate Professor, Department of Epidemiology, School of Public Health and Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington. 2005–present Full Professor, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 2002–present Professor, Fred Hutchinson Cancer Research Center/ University of Washington Cancer Consortium, Seattle, Washington 2001-2006 Affiliate Associate Professor, Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington. 2000-2006 Affiliate Associate Professor, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington. 1999-2005 Associate Professor, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1999 Assistant Professor, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1997-present Graduate School Faculty, Department of Epidemiology, University of Washington, Seattle, Washington. 1995-1999 Assistant Professor, Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1993-present Member, Women Health Initiative Clinical Coordinating Center Laboratory Working group, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1993-1997 Founder and Director of Public Health Sciences Core Laboratory, Program in Cancer Biology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1992, 1996 Clinical Laboratory Inspector, College of American Pathologists. 1992-1993 Clinical Chemist, Providence Hospital, Everett, Washington. 1974-1976 Research Technician II, Division of Ophthalmology, Department of Surgery, Case Western Reserve University, Cleveland, Ohio. Project: Chemistry of Rhodopsin. 1972-1974 Senior Research Technician, Michigan State University/Atomic Energy Commission Plant Research Laboratory, East Lansing, Michigan. Project: Physiology of Abscisic Acid and Xanthoxin. 1972 Medical Mycologist/Microbiologist, Clinical Laboratory, W.A. Foote Memorial Hospital, Jackson, Michigan. Chu Chen Page 2 of 64 CURRENT GRANT SUPPORT 1. Clinical Coordinating Center for the Clinical Trial and Observation of the Women’s Health Initiative NIH/NHLBI N01-WH-11-11, Contract #: HHSN268201600018C, 4/1/2016-01/31/2026 Principal Investigator: Garnet Anderson The major goal of this project is to establish and operate a Clinical Coordinating Center to support the Women’s Health Initiative Clinical Trial and Observational Study. Role on Project: Co-Investigator 2. Infrastructure Support and Pilot Tissue Collection for the CARET Biorepository NIH/NCI 2U01 CA167462-06 4/1/2018 – 3/31/2023 The CARET Biorepository has longitudinally collected pre-diagnostic serum and plasma samples as well as DNA samples on 18,314 participants at high risk for lung cancer, with demographic, lifestyle, and nutrition characteristics, and 20 years of follow-up for cancer incidence, survival, and cause of death. This well-maintained specimen bank makes the CARET Biorepository well suited to any investigator who proposes to study the molecular, genetic, and nutritional epidemiology, as well as markers for early detection, diagnosis, and prognosis of the common cancers in both men and women. Role on Project: Principal Investigator 3. Integrative Analysis of Lung Cancer Etiology and Risk – Biomarkers of Lung Cancer Risk (LC3-II) NIH/NCI U19CA203654-01A1 2/28/2020 – 3/31/2022 Principal Investigator: Mattias Johansson Our overarching aims are i) to evaluate a comprehensive panel of promising biomarkers of lung cancer risk, ii) identify those biomarkers most informative on risk, and iii) evaluate the extent to which they improve lung cancer risk prediction models. This will be achieved by bringing together data from ongoing biomarker studies and conducting de novo laboratory analyses of a comprehensive panel of promising risk biomarkers within the Lung Cancer Cohort Consortium (LC3). Role on Project: Subaward Principal Investigator PREVIOUS GRANT SUPPORT 1. GM3 Sialytransferase and Cell Transformation. Individual National Research Service Award, F32 CA07491 11/03/1983-11/02/1986 Award: $59,736 Role on Project: Principal Investigator 2. Glutathione S–Transferase and Anogenital Cancers. NIH R01 ES06728, 5/1/1994-11/30/1997 Award: $725,988 Role on Project: Principal Investigator 3. Effects of Soy and Wheat Bran Feeding on Serum and Urinary Steroid Hormone Levels in Premenopausal Women: A Pilot Project. Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas NIH/NCI R21 CA66186 1/1/1996-12/31/1996 Award: $15,000 Role on Project: Principal Investigator 4. Estrogen Receptor Polymorphisms and Breast Cancer in Young Women: A Pilot Project Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas. Chu Chen Page 3 of 64 NIH/NCI R21 CA66186 1/1/1998-12/31/1998 Award: $15,415 Role on Project: Principal Investigator 5. Prostate Cancer in Chinese Men Laboratory component of a case–control study conducted by Dr. Ann Hsing of the Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute. NCI Contract 263–MQ–822580 2/1/1999–8/31/1999 Award: $80,080 Role on Project: Principal Investigator 6. Phytoestrogens, Organochlorines, and Fibroid Risk NIH/NIEHS 5 R01 ES08305, Principal Investigator: Stephen Schwartz 9/1/1996-8/31/2001 Award: $665,420 Role on Project: Co–Investigator 7. Diet, Cell Proliferation, and Breast Cancer in Shanghai NIH/NCI R01 CA75332, Principal Investigator: David Thomas 7/1/1997-6/30/2002 Award: $363,782 Role on Project: Co–Investigator 8. Oral Cancer: DNA Polymorphisms in Carcinogen Metabolism NIH R01 DE 12609, Principal Investigator: Stephen Schwartz 9/1/1998-6/30/2002 Award: $1,058,643 Role on Project: Co–Investigator 9. 60–Hz Magnetic Fields and Hormone Levels in Women NIH R01 CA80346, Principal Investigator: Scott Davis 9/1/1998–3/31/2002 Award: 1,234,735 Role on Project: Co–Investigator 10. Endometrial Cancer and CYP1A1, GSTM1 & T1 Polymorphisms NIH/NCI R03 CA 80636 10/1/1998–8/31/2001 Award: $172,967 Role on Project: Principal Investigator 11. Endogenous Sex Hormones, Genetics, and Prostate Cancer NIH/NCI R01 CA78812 4/1/1999-3/31/2003 Award: $988,629 Role on Project: Principal Investigator 12. Reproductive/Contraceptive Risk Factors & Endometriosis NIH/NICHD R01 HD–33792–05, Principal Investigator: Victoria Holt 7/1/1999-4/30/2003 Award: $445,874 Role on Project: Co–Investigator. 13. Adiposity Related Biomarkers and Breast Tumor Size Chu Chen Page 4 of 64 NIH R03 CA91251, Principal Investigator: Kathleen Malone 4/1/2001-3/31/2003 Award: $171,905 Role on Project: Co–Investigator. 14. Breast Cancer and the Birth Control Pill: Case–Control Study of Perimenopausal and Past Oral Contraceptive Use NIH/NCI N01 HD–2–3166, Principal Investigator: Janet Daling 9/30/1992-9/29/2003 Award:
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