Curriculum Vitae

YING QING CHEN, PH.D.

Contact Information

Fred Hutchinson Cancer Research Center 1100 Fairview Ave N, M2-C200 Seattle, WA 98109-1024

Phone: (206) 667-7051 Fax: (206) 667-4837 E-mail: [email protected]

Education

1992 B.S. in Computational Mathematics, Peking University, Beijing, China 1999 Ph.D. in Biostatistics, Johns Hopkins University, Baltimore, MD

Primary Position

1999 - 2004 Sweesy-Womack Assistant Professor, Division of Biostatistics, School of Public Health, University of California, Berkeley, CA (on leave 2003 - 2004) 2003 - 2004 Associate Professor, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 2004 - 2011 Associate Member, Public Health Sciences Division (PHS) and Vaccine and Infectious Disease Division (VIDD), Fred Hutchinson Cancer Research Center, Seattle, WA 2011 - Present Full Member, PHS Division and VIDD, Fred Hutchinson Cancer Research Center, Seattle, WA

Teaching Experience

1994 - 1999 Teaching Assistant, Department of Biostatistics, Johns Hopkins University, Baltimore, MD 1999 - 2000 Adjunct Assistant Professor, Department of Biostatistics, Johns Hopkins University, Baltimore, MD 1999 - 2004 Assistant Professor, Graduate Program in Biostatistics, University of California, Berkeley, CA 2003 - 2004 Associate Professor, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 2004 - 2012 Affiliate Associate Professor, Department of Biostatistics, University of Washington, Seattle, WA 2012 - Present Affiliate Professor, Department of Biostatistics, University of Washington, Seattle, WA

Consulting Experience

1995 - 1996 Statistical Consultant, Department of International Health and Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD 1996 - 1997 Statistical Consultant, School of Nursing, Johns Hopkins University, Baltimore, MD

1997 - 1999 Statistical Consultant, Research and Evaluation Office, JHPIEGO Corporation, Baltimore, MD Department of Epidemiology, Johns Hopkins University, Baltimore, MD 2001 - 2002 Statistical Consultant, Novartis Pharmaceuticals, East Hanover, NJ

Professional Affiliation

1996 - Present American Statistical Association (ASA) 1998 - Present International Biometric Society (IBS) 1998 - Present International Chinese Statistical Association (ICSA) 1999 - Present Society for Clinical Trials (SCT) 2010 - Present International AIDS Society (IAS)

Professional Activity

Graduate Student Admissions: 2008 - 2010 Member, Graduate Student Admissions Committee, Department of Biostatistics, University of Washington, Seattle, WA

Graduate Student Advisory: 2000 - 2001 Yun Zhou (UC Berkeley) 2001 - 2002 Yue Wang (UC Berkeley), Jingrong Yang (UC Berkeley) 2002 - 2003 Jie Fan (UC Berkeley), Xiudong Lei (UC Berkeley), Hui Tang (UC Berkeley), Jingrong Yang (UC Berkeley) 2007 - 2010 Erin Gabriel (U Washington) 2017 - Present Xiaoyue Wang (U Washington)

Master's Comprehensive Exam Committees: 1999 - 2000 Susan Alber (Chair, UC Berkeley), Tephillah Chi (Chair, UC Berkeley), Christian Bottomley (Member, UC Berkeley), Sunduz Keles (Member, UC Berkeley) 2000 - 2001 Ling Liu (Member, UC Berkeley), Kamalika Chaudhury Banerjee (Chair, UC Berkeley) 2001 - 2002 Yun Zhou (Chair, UC Berkeley), Jingrong Yang (Chair, UC Berkeley) 2002 - 2003 Ed Bein (Member, UC Berkeley) 2003 - 2004 Hui Tang (Member, UC Berkeley)

Master’s Thesis Committees 2017 - 2018 Xiaoyue Wang (Chair, U Washington)

Applied Statistics Examination: 2005 - 2015 Reader and Member of Oral Exam Committees Department of Biostatistics, University of Washington, Seattle, WA

Doctoral Candidacy Admission Exam Committee: 2001 - 2002 Joyce S. Chung (Member, UC Berkeley), Aron Ross Shlonsky (Member, UC Berkeley) 2002 - 2003 Xiudong Lei (Chair, UC Berkeley), Jingrong Yang (Chair, UC Berkeley), Yun Zhou (Member, UC Berkeley) 2003 - 2004 R. Prasana Venkateswaran (Member, UC Berkeley)

Doctoral Dissertation Committee:

2000 - 2001 Michal Weingart (Member, UC Berkeley) 2001 - 2002 John William McMurray (Member, UC Berkeley) 2002 - 2004 Xiudong Lei (Chair, UC Berkeley), Jingrong Yang (Chair, UC Berkeley) 2007 - 2010 Nan Hu (Member, U Washington) 2007 – 2011 Kenneth Wu (Chair, U Washington), Giancarlo Sal y Rosas (Member, U Washington) 2010 - 2012 Shanshan Zhao (Member, U Washington), Erin Gabriel (Member, U Washington), Michal Jureska (Member, U Washington) 2011 - 2013 Luis Alexanda Crouch (Chair, U Washington) 2011 - 2014 Megan Smith (Chair, U Washington), Wei Zhao (Co-Chair, U Washington), Jie Hu (Member, U Washington), Rong Fu (Member, U Washington) 2011 - 2015 Marlena Maziara (Member, U Washington), Cheng Zheng (Member, U Washington) 2011 - 2016 Wenying Zheng (Chair, U Washington) 2012 - 2017 Angela Ulrich (GSR, U Washington), Yingying Zhuang (Member, U Washington) 2017 - Present Jessica Long (GSR, U Washington), Rui Zhuang (Member, U Washington), Anqi Cheng (Member, U Washington), Xiangyang Guan (GSR, U Washington)

Seminar/Symposium/Conference Organizer: 2005 - 2006 Hutch Biostatistics Seminars 2005 - 2007 SCHARP Statistical Sciences Brown Bag Seminars 2005 - 2010 University of Washington Biostatistics Departmental Seminars 2006 - 2007 Joint Hutch/UW Biostatistics Retreat 2008 - 2009 VIDD Symposiums 2009 - 2010 WNAR 2010 Local Program 2014 - 2015 ICSA Applied Symposium Local Program 2015 - 2016 ICSA JSM Local Program

Professional Societal Services: 2001 - 2003 Treasurer, ASA Bay Area Chapter 2008 - 2009 Chair, ICSA Biometrics Section 2012 - Present Mathematical Reviewer, Mathematical Reviews, American Mathematical Society

Editorial Board: 2002 - 2003 Advisor, Berkeley Wellness Letter 2008 - 2011 Associate Editor, Statistica Sinica 2011 - Present Associate Editor, Lifetime Data Analysis 2015 - Present Associate Editor, Communication in Contemporary Clinical Trials

Journal Reviewer: American Statistician, Annals of Applied Statistics, Annals of Epidemiology, Annals of Statistics, Australian and New Zealand Journal of Statistics, Biometrics, Biometrical Journal, Biometrika, Biostatistics, Canadian Journal of Statistics, Communication in Statistics, Controlled Clinical Trials, Environmetrics, Health Services and Outcomes Research Methodology, International Journal of Biostatistics, Journal of American Statistical Association, Journal of Applied Statistics, Journal of Computer Graphics and Statistics, Journal of Nonparametric Statistics, Journal of Royal Statistical Society series B/C, Journal of Statistics in Biopharmaceutical Research, Journal of Theoretical Biology, Journal of Statistical Planning and Inference, Lifetime Data Analysis, Metron, PLoS One, Scandinavian Journal of Statistics, Statistics in Biosciences, Statistics in Medicine, Statistica Sinica, Statistics and Probability Letters

Research Grant/Project Review Panel: 2007 - 2008 Reviewer, Division of Mathematical Sciences, National Science Foundation

2010 - 2011 Reviewer, Study Section on the AIDS Clinical Studies and Epidemiology (ACE), National Institutes of Health (NIH) 2010/05-10 Council Rounds 2011 Reviewer, NIH/PEPFAR Collaboration for Implementation Science and Impact Evaluation RFA (AI-11-003) 2011 - 2015 Chartered Reviewer, Study Section on ACE, NIH 2013 - 2015 Reviewer, NIH/NCI Program Project Grant (P01) Special Emphasis Panel 2013/06 ZCA1 RPRB-J (M1), 2013/10 ZCA1 RPRB-J (O1), 2014/09 ZCA1 RPRB-J (M1), 2015/01 ZCA1 RPRB-J (J1), 2015/06 ZCA1 RPRB-J (O1) 2016 Reviewer, NIH/AIDSRRC Independent Special Emphasis Panel 2016/01 ZAI1 FDS-M (J2) 1 2016 Reviewer, Center for Diseases Control (CDC) for Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) 2016 Reviewer, NIH Special Emphasis Panel on AIDS and Related Research ZRG1 AARR-K (94) 2017 Reviewer, NIH Special Emphasis Panel on AIDS and Related Research 2017/05 ZRG1 AARR-G (02) 2017 Reviewer, Study Section on Behavioral and Social Sciences Approaches to Preventing HIV/AIDS (BSPH) Study Section, NIH 2017/10 Council Round 2017 Reviewer and Chair, NIH Special Emphasis Panel on AIDS and AIDS Related Research 2017/10 ZRG1 AARR-G (02) 2018 Reviewer, NIH Special Emphasis Panel on PAR-16-292 “Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21)” 2018/02 ZRG1 HDM-Z (52) 2018 Reviewer, NIH Study Section on Biomedical Computing and Health Informatics (BCHI) 2018/10 BCHI 2018 Reviewer, NIH Special Emphasis Panel on PAR “Health Services Research on Minority Health and Health Disparities” 2018/10 ZRG1 HDM-Y (56) R 2018 Reviewer, NIH/NIAID Special Emphasis Panel on PAR-16-272/PAR-18-633 “NIAID Clinical Trial Planning Grant” 2018/10 ZAI CB-A (S1) 2015 - Present Member, University of Hawaii Data Safety Monitoring Board (DSMB) for H024 Maraviroc and NeuroAIDS Pathogenesis 2016 - Present Member, National Institute of Heart, Lung and Blood (NHLBI) DSMB for the Influenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure (INVESTED) Trial

Center/University Committee: 2005 - 2006 Institutional Review Board Cultural Consultant 2010 - 2012 VIDD Faculty Appointments and Promotion Committee 2008 - Present VIDD/PHS Faculty Search/Review/Promotion Committees

Presenter in professional conferences: 1998 - 1999 International Biometric Society (IBS) Conference, Cape Town, South Africa IBS East-North America Region (ENAR) Meeting, Atlanta, GA Society for Clinical Trials (SCT) Annual Meeting, Anaheim, CA International Chinese Statistical Association (ICSA) Applied Statistics Symposium, DC 1999 - 2000 American Statistical Association (ASA) Joint Statistical Meeting, Baltimore, MD IBS ENAR Meeting, Chicago, IL Mathematical Modeling in Reliability Conference, Bordeaux, France

2000 - 2001 IBS ENAR Meeting, Charlotte, NC ICSA Applied Statistics Symposium, Chicago, IL 2001 - 2002 IBS ENAR Meeting, Crystal City, VA Mathematical Modelling in Reliability 2002 Meeting, Trondheim, Norway ASA Joint Statistical Meeting, New York, NY 2002 - 2003 IBS ENAR Meeting, Tampa, FL International Conference on Reliability and Survival Analysis, Columbia, C ASA Joint Statistical Meeting, San Francisco, CA 2003 - 2004 ASA Joint Statistics Meeting, Toronto, ON 2004 - 2005 ASA Joint Statistics Meeting, Minneapolis, MN 2006 - 2007 ICSA International Statistical Symposium, Taipei, Taiwan 2007 - 2008 SCT Annual Meeting, St. Louis, MO 2010 - 2011 ICSA Applied Statistics Symposium, Boston, MA 2011 - 2012 IBS WNAR Meeting, Fort Collins, CO 2013 - 2014 ICSA International Statistical Symposium, Taipei, Taiwan 2014 - 2015 IBS ENAR Meeting, Miami, FL ASA Joint Statistics Meeting, Seattle, WA 2015 - 2016 IBS ENAR Meeting, Austin, TX HIV Prevention Trials Network Annual Meeting, Washington, DC ASA Joint Statistical Meeting, Chicago, IL International Mathematical Society (IMS) Asia Pacific Rim Meeting, Hong Kong, China 2016 - 2017 ASA Regulatory-Industry Statistics Workshop, Washington, DC IBS ENAR Meeting, Washington, DC

Invited speaker: 1998 - 1999 Harvard University Biostatistics Department University of Texas at Houston Biometry Department M.D. Anderson Cancer Center Biomathematics Department University of Connecticut Statistics Department Southern Methodist University Statistics Department 1999 - 2000 UC San Francisco Biostatistics & Epidemiology Department UC Berkeley Statistics Department UC Davis Statistics Department U.S. Food and Drug Administration, Rockville, MD 2000 - 2001 Peking University Probability and Statistics Department Fred Hutchinson Cancer Research Center University of North Carolina Biostatistics Department UC Davis Statistics Department Texas A&M University Statistics Department 2001 - 2002 Celera Diagnostics Novartis Pharmaceuticals 2002 - 2003 Merck Research Laboratories Oregon State University Statistics Department UC Riverside Statistics Department Fred Hutchinson Cancer Research Center UC Davis Department of Biostatistics and Epidemiology University of Florida Department of Statistics 2003 - 2004 Forest Laboratories National Cancer Institute Georgia State University Department of Mathematics and Statistics

University of Florida Department of Epidemiology and Health Policy 2004 - 2005 UC Berkeley Statistics Department University of Washington Biostatistics Department National University of Singapore Institute of Mathematical Sciences 2005 - 2006 China Centers for Disease Control Peking Union Medical College School of Public Health University of Washington Biostatistics Department 2006 - 2007 UC San Francisco Biostatistics & Epidemiology Department 2007 - 2008 Johns Hopkins University Biostatistics Department 2008 - 2009 University of Connecticut Department of Statistics University of Toronto School of Public Health University of Texas at Houston School of Public Health 2009 - 2010 Brown University Center for Statistical Sciences 2010 - 2011 Vanderbilt University Department of Biostatistics 2011 - 2012 Memorial Sloan-Kettering Cancer Center Epidemiology & Biostatistics Department 2014 - 2015 UC San Francisco Biostatistics & Epidemiology Department 2015 - 2016 U Maryland Epidemiology and Biostatistics Department U Missouri Statistics Department Ritsumeikan U College of Economics 2016 - 2017 U Buffalo Biostatistics Department NIH/NICHD Biostatics and Bioinformatics Branch 2017 - 2018 Emory University Rollins School of Public Health Columbia University Biostatistics Department Rutgers Department of Biostatistics

Honor and Award

1994 - 1996 Fellowship, Johns Hopkins University, Baltimore, MD 1994 - 1999 Tuition Scholarship, Johns Hopkins University, Baltimore, MD 1998 - 1999 Young Investigators Travel Grant to IBS, Cape Town, South Africa 1999 - 2000 Margaret Merrell Award, Johns Hopkins University, Baltimore, MD 1999 - 2000 The Thomas Charlmers Award, SCT, Anaheim, CA 1999 - 2000 Student Award and Travel Fellowship, ICSA, Washington, DC 2001 - 2002 Hellman Family Faculty Fund, University of California, Berkeley, CA 2001 - 2004 Sweesy-Womack Endowed Chair, University of California, Berkeley, CA 2003 - 2004 Stanley Schor Visiting Scholar, Merck Research Laboratories, Rahway, NJ 2018 Elected Fellow, ASA

Research Funding

Past/Completed 1999 - 2000 Sub-Award PI, 5%, Analysis of Schizophrenia Hospitalizations Johns Hopkins University, PI: William W. Eaton 1999 - 2001 PI, 10%, Startup Fund University of California, Berkeley 1999 - 2001 PI, 5%, Faculty Research Enabling Grant University of California, Berkeley 1999 - 2001 PI, 10%, Junior Faculty Research Grant University of California, Berkeley 1999 - 2001 PI, 5%, Junior Faculty Mentor Grant University of California, Berkeley

2001 - 2002 PI, 10%, Marin County Breast Cancer Risk Factor Study California Department of Health 2001 - 2003 PI, 15%, Hellman Family Faculty Fund University of California, Berkeley 2002 - 2003 PI, 10%, Faculty Research Fund University of California, Berkeley 2001 - 2004 PI, 15%, Sweesy and Womack Fund University of California, Berkeley 2003 - 2005 Investigator, 10%, Social Capital and Cardiovascular Health in California CDC, PI: Richard Schafer 2004 - 2005 Investigator, 15%, Economic & Policy Analysis of ADHD & Stimulant Drugs NIH/NIMH, PI: Richard Schafer 2006 - 2009 Investigator, 10%, IMPAACT Network, NIH/NIAID, PI: Jackson Brooks 2007 - 2009 Investigator, 5%, Whole Genome Association Analysis of HCT Outcome NIH/NIHLB, PI: John Hansen 2007 - 2011 Investigator, 15%, Assessing Genetic Association with Time-Varying Phenotype NIH/NCI, PI: Lue Ping Zhao 2008 - 2011 Investigator, 5%, Designs and Methods for Sequence-based Validation Analysis NIH/NIMH, PI: Lue Ping Zhao (FHCRC) 2008 - 2012 Sub-Award PI, 20%, Statistical Methods for HIV/AIDS Research NIH/NIAID, PI: Mei-Cheng Wang (Johns Hopkins) 2010 - 2014 Investigator, 7%, Transdisciplinary Studies of Genetic Variation in Colorectal Cancer Consortium NIH/NCI U19 CA148107, PI: Ulrike Peters (FHCRC) 2010 - 2014 PI, 30%, Statistical Methods in HIV/AIDS Research ($1,280,471) NIH/NIAID R01 AI089341, PI: Ying Qing Chen 2006 - 2015 Investigator, 5%, Statistical Methods for Medical Studies NIH/NCI, PI: Ross Prentice 2010 - 2016 Biostatistician, 5%, Ganciclovir/Valganciclovir for Prevention of Cytomegalovirus Reactivation in Acute Injury of the Lung and Respiratory Failure (GRAIL) NIH/NHLBI, PI: Michael Boechk (FHCRC) 2012 - 2017 PI, 10%, Statistical Data Analysis Center for DSMB of the Lurasidon Schizophrenia Pediatric Clinical Trials Sunovion Pharmaceuticals, PI: Ying Qing Chen 2013 - 2018 PI, 30%, Methods for Time-Varying Attribution in Chronic Disease Research (Year 1: $355,251; 2017 - 2018, NCE) NIH/NCI R01 CA172415, PI: Ying Qing Chen

Current/Ongoing 2014 - 2019 PI, 20%, Statistical Methods for Combination Prevention Studies in HIV/AIDS Research (Year 1: $519,210) NIH/NIAID R01 MH105857, PI: Ying Qing Chen 2015 - 2019 PI, 25%, Statistical Methods for Adherence Issues in HIV Prevention Research (Year 1: $630,172) NIH/NIAID R01 AI121259, PI: Ying Qing Chen 2017 - 2022 PI, 20%, Predicting PrEP Uptake and Adherence among Adolescent Girls and Young Women in Sub-Saharan Africa: Leveraging Programmatic and Clinical Trials Data (Year 1: $650,778) 2018 - 2023 PI, 20%, Methods for Complex Longitudinal Data in HIV/AIDS Prevention Research (Year 1: $608,917)

NIH/NIAID R56 AI140953, PI: Ying Qing Chen 2013 - 2019 Sub-Award PI, 10%, Statistical Issues in AIDS Research NIH/NIAID R01 AI029168, PI: James Hughes (U Washington) 2015 - 2019 Co-Investigator/Biostatistician, 5%, Modulating the Impact of Critical Events in Early HIV Infection: Effect of Early ART Initiation and Alcohol Use NIH/NIAID R01 DA040532, PI: Ann Duerr (FHCRC) 2004 - 2020 Investigator, 10%, Leadership for HIV/AIDS Clinical Trials Network NIH/NIAID UM1 AI068617, PI: Deborah Donnell (FHCRC)

Pending 2018 - 2023 Co-PI, 15%, Methods for Mobile Device Data in Precision Public Health Research NIH/NIGMS R01 GM129572, PI’s: Ying Qing Chen and Chongzhi Di 2019 - 2026 PI, 15%, 2/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and Sepsis NIH/NHLBI U24 HL147012, PI: Ying Qing Chen

Collaborative Research Projects

2000 - 2004 Pediatric Asthma Study University of California, Berkeley, PI: Sylvia Guendelman 2002 - 2003 Patterns of Survival Following Colorectal Cancer University of California, Berkeley, PI: William Satariano 2002 - 2004 Chinese-American Neurological and Geriatric Study of Health Outcomes University of California, Berkeley, Principal Investigator: William Satariano 2002 - 2004 Social Capital and Cardiovascular Health in California University of California, Berkeley, PI: Richard Schafer 2002 - 2004 An Economic and Policy Analysis of ADHD and Stimulant Drugs UC Berkeley School of Public Health, PI: Richard Schafer 2004 - 2009 HPTN 046 Phase III Trial to Determine the Efficacy and Safety on an Extended Regimen of Nevirapine in Infants Born to HIV-infected Women to Prevent Vertical HIV Transmission during Breastfeeding. Protocol Chair: Hoosen M. Coovadia 2004 - 2010 HIVNET 024 Phase III Trial of Antibiotics to Reduce Chrioamnionitis-related Perinatal HIV Transmission. Protocol Co-chairs: Taha E. Taha and Robert Goldenberg 2004 - Present HPTN 052 Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples. Protocol Co-Chairs: Myron Cohen, et al. 2010 - Present HPTN 069 NEXT-PREP: Novel Exploration of Therapeutics for PREP - A Phase II Randomized, Double-Blind, Study of the Safety and Tolerability of Maraviroc (MVC), Maraviroc + Emtricitabine (MVC+FTC), Maraviroc + Tenofovir disoproxil fumarate (MVC+TDF), or Tenofovir disoproxil fumarate + Emtricitabine (TDF+FTC) for Pre-Exposure Prophylaxis (PrEP) to Prevent HIV Transmission in At-Risk Men Who Have Sex with Men. Protocol Chairs: Roy Gulick, et al. 2011 - Present HPTN MSM Scientific Committee, HPTN Study Monitoring Committees 2011 - Present HPTN 073 PrEP Uptake and Adherence among Black MSM in Three US Cities. Protocol Chair: Darrell Wheeler and Sheldon Fields 2013 - Present HPTN 075 Characterizing the Feasibility of HIV Prevention Cohort Studies Among Men Who Have Sex with Men in Sub-Saharan Africa. Protocol Chairs: Theo Sandfort, et al.

Publication

Peer-reviewed work: 1. Brookmeyer, R., Chen, Y. Q. (1998) Person-time analysis of paired community intervention trials when the number of communities is small, Statistics in Medicine, 17:2121-32. 2. Chen, Y. Q., Wang, M.-C. (2000) Analysis of accelerated hazards model, Journal of the American Statistical Association, 95:608-618. 3. Chen, Y. Q., Wang, M.-C. (2000) Estimating a treatment effect with the accelerated hazards model, Controlled Clinical Trials, 21:369-380. 4. Wang, M.-C., Chen, Y. Q. (2000) Parametric and semiparametric trend analysis for stratified recurrence times, Biometrics, 56:789-794. 5. Chen, Y. Q., Jewell, N. P. (2001) On a general class of hazards regression models, Biometrika, 88:687-702. 6. Chen, Y. Q. (2001) Accelerated hazards regression model and its adequacy for censored survival data, Biometrics, 57:853-860. 7. Wang, M.-C., Chen, Y. Q. (2001) Comment on “Semiparametric and nonparametric regression analysis of longitudinal data” by Lin and Ying, Journal of the American Statistical Association, 96:113-114. 8. Chen, Y. Q., Rohde, C. A., Wang, M.-C. (2002) Additive hazards models with latent treatment effectiveness lag time, Biometrika, 89: 914-931. 9. Chen, Y. Q., Wang, M.-C, Huang, Y. (2002) Analysis of recurrent event data: inference based on reduced risksets, Communications of the 3rd International Conference on Mathematical Methods in Reliability, (Eds. H. Langseth & B. Lindqvist). 147-150. Trondheim, Norway. 10. Guendelman, S., Meade, K., Benson, M., Chen, Y. Q. (2002) Improving asthma outcomes and self-management behaviors of inner city children through interactive technology: a randomized controlled trial of the Health Buddy System, Archives of Pediatric & Adolescent Medicine, 156:114-120. 11. Chen, Y. Q., Pong, A., Xing, B. (2003) Rank regression in stability analysis, Journal of Biopharmaceutical Statistics, 13:463-479. 12. Chen, Y. Q., Jewell, N. P., Yang, J. R. (2003) Accelerated hazards model: method, theory and applications. Handbook of Statistics on Survival Analysis, Amsterdam: North-Holland. 13. Huang, Y., Chen, Y. Q. (2003) Marginal regression of gaps between recurrent events, Lifetime Data Analysis, 9:293-303. 14. Lin, M. C., Chen, Y. Q., Polse, K. A. (2003) The effects of ocular and lens parameters on the post-lens tear thickness, Eye & Contact Lens: Science and Clinical Practice, 29(1): S33-S36. 15. Pong, A., Chen, Y. Q., Lei, X. (2003) Semiparametric rank regression methods in stability analysis, Encyclopedia of Biopharmaceutical Statistics, New York: Dekker. 16. Gaffikin, L., Ahmed, S., Chen, Y. Q., McGrath, J.M., Blumenthal, P.D. (2003) Risk factors as the basis for triage in low-resource cervical cancer screening programs, International Journal of Gynecology & Obstetrics, 80: 41-47. 17. Lin, M. C., Soliman, G. N., Song, M., Smith, J. P., Lin, C. T., Chen, Y. Q., Polse, K. A. (2003) Extended wear effects on epithelial permeability: Hypoxic or mechanical mechanism? Contact Lens & Anterior Eye, 26: 11-16. 18. Chen, Y. Q., Wang, M.-C, Huang, Y. (2004) Semiparametric regression analysis on longitudinal pattern of recurrent gap times, Biostatistics, 5: 277-290. 19. Kent, C. K., Chaw, J. K., Kohn R. P., Chen, Y. Q., Klausner, J. D. (2004) Studies relying on passive retrospective cohorts developed from health services data provide biased estimates of incidence of sexually transmitted infections. Sexually Transmitted Diseases, 31:596-600. 20. Guendelman, S., Meade, K., Chen, Y. Q., Benson, M. (2004) Asthma control and hospitalizations among inner-city children: results of a randomized trial of the health buddy interactive device, Telemedicine Journal and e-Health, 10(S2): S6-S14.

21. Chen, Y. Q., Cheng, S.-C. (2005) Semiparametric analysis of proportional mean residual life model with censored survival data, Biometrika, 92, 19-29. 22. Chen, Y. Q., Jewell, N. P., Lei, X., Cheng, S.-C. (2005) Semiparametric estimation for proportional mean residual model in presence of censoring, Biometrics, 61, 170-178. 23. Zhao, W., Chen, Y. Q., Casella, G., Cleverud, J. M., Wu, R. L. (2005) A nonstationary models for functional mapping of complex traits, Bioinformatics, 21, 2469-2477. 24. Chen, Y. Q., Cheng, S.-C. (2006) Linear life expectancy regression with censored data, Biometrika, 93, 303-313. 25. Chen, Y. Q., Hu, C., Wang, Y. (2006) Attributable risk functions in the proportional hazards model for censored time-to-events, Biostatistics, 7, 515-529. 26. Long, F., Chen, Y. Q., Cheverud, J. M., Wu, R. L. (2006) Genetic mapping of allometric scaling laws, Genetical Research, 87, 207-216. 27. Chen, Y. Q. (2007) Additive expectancy regression, Journal of the American Statistical Association, 102, 153-166. 28. Chen, Y. Q., Yang, J., Cheng, S.-C., Brooks, J. B. (2007) Estimating a treatment effect with repeated measurements accounting for varying effectiveness duration, Biometrika, 94, 387-402. 29. Chen, Y. Q. (2008) Attributable risk. Encyclopedia of Medical Decision Making (Ed. Michael Kattan). Thousand Oakes: SAGE. 30. Chasela, C., Chen, Y. Q., Fiscus, S., Hoffman, I., Young, A., Valentine, M., Emel, L., Taha, T. E., Goldenberg, R., Reid, J. (2008) Risk factors for late postnatal transmission of Human Immunodeficiency Virus Type 1 in Sub-Saharan Africa, Pediatric Infectious Diseases Journal, 27, 251-256. 31. Aboud, S., Msamanga, G, Read, J. S., Mwatha, A., Chen, Y. Q., Potter, D., Valentine, M., Sharma, U., Taha, T. E., Goldnenberg, R. L. and Fawzi, W. W. (2008) Genital Tract Infections among HIV-Infected Pregnant Women in Malawi, Tanzania and Zambia, International Journal of STD & AIDS, 12, 824-832. 32. Chen, Y. Q. (2009) Review on Statistical Design and Analysis of Stability Studies by Shein- Chung Chow. Journal of the American Statistical Association, 485, 419-419. 33. Kafulafula, G., Mwatha, A., Chen, Y. Q., Aboud, S., Martinson, F., Hoffman, I., Fawzi, W., Read, J. S., Valentine, M., Mwinga, K., Goldenberg, R. L. and Taha, T. E. (2009) Intrapartum Antibiotic Exposure and Early Neonatal Morbidity and Mortality in Africa, Pediatrics, 124, e137-e144. PMCID: PMC2764263. 34. Mwinga, K., Vermund, S. H., Chen, Y. Q., Mwatha, A., Read, J. S., Urassa, W., Carpenetti, N., Valentine, M., Goldenberg, L. (2009) Selected hematologic and biochecmical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 Protocol. BMC Pediatrics, 9:49. doi:10.1186/1471-2431-9-49. 35. Chen, Y. Q. (2010) Semiparametric regression in size-biased sampling, Biometrics, 66, 149 -158. PMCID: PMC2875362. 36. Chen, Y. Q., Young, A., Brown, E. R., Chasela, C., Fiscus, S., Hoffman, I., Valentine, M., Emel, L., Taha, T. E. and Read, J. S. (2010) Risk factors for late postnatal mother-to-child transmission of human immunodeficiency virus type-1 in sub-Saharan Africa: assessing population attributable fractions. Journal of AIDS, 54, 311-316. 37. Brown, E. R., Chen, Y. Q. (2010) An imputation method for censored time-to-event with auxiliary information: analysis of the timing of mother-to-child transmission of HIV, Statistical Communications in Infectious Diseases, Vol 2: Issue 1, Article 8. 38. Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M., Kumarasamy, N., Hakim, J., Kumwenda, J., Grinsztejn, B., Pilotto, J., Godbole, S., Mehendale, S., Chariyalertsak, S., Santos, B., Mayer, K., Hoffman, I., Eshleman, S., Piwowar-Manning, E., Wang, L., Makhema, J., Mills, L., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T., Nielsen, K., Celentano, D., Essex, M., Fleming, T., and the

HPTN 052 Protocol Team (2011), Prevention of HIV-1 infection with early antiretroviral therapy, New England Journal of Medicine, 365, 493-505; PMID: 21767103; PMCID: PMC3200068. 39. Cohen, M. S., Chen, Y. Q., and Fleming, T. S., for the HPTN 052 Team (2011) Authors/editor response: prevention of HIV-1 infection with antiretroviral therapy, New England Journal of Medicine, 365, 1934-1935. 40. Eshleman, S. S., Hudelson, S., Redd, A., Wang, L., Debes, R., Chen, Y. Q., Martens, C., Ricklefs, S., Selig, E., Porcella, S., Mushaw,S., Ray, S., Piwowar-Manning, E., McCauley, M., Hosseinipour, M., Kumwenda, J., Hakim, J., Chariyalertsak, S., de Bruyn, G., Grinsztejn, B., Kumarasamy, N., Makhema, J., Mayer, K., Pilotto, J., Santos, B., Quinn, T., Cohen, M. S., and Hughes, J. (2011), Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial, Journal of Infectious Disease, 204: 1918-1926; PMID: 21990420; PMCID: PMC3209811. 41. Chen, Y. Q., Zhang, X. and Zhao, L.-P. (2011) Estimating a scale-change effect for time-varying phenotypes in genome-wide association studies, Journal of Applied Statistical Science, 18 (4), 31-46. 42. Chen, Y. Q., Hu, N., Cheng, S., Phillippa, M. and Zhao, L.-P. (2012) Estimating regression parameters in an extended proportional odds model, Journal of the American Statistical Association, 107: 318-330. 43. Chen, Y. Q., Masse, B., Wang, L., Ou, S.-S., Li, X., Donnell, D., Marybeth, M., Gamble, T., Ribauldo, H., Cohen, M. S. and Fleming, T. S. (2012) Statistical considerations for a randomized trial to evaluate the effectiveness of antiretroviral therapy plus HIV primary care versus HIV primary care alone to prevent the sexual transmission of HIV-1 serodiscordant couples. Contemporary Clinical Trials, 33: 1280-1286; PMID: 22813645; PMCID: PMC3468650 44. Chan, G., Chen, Y. Q. and Di, C. (2012) Proportional mean residual life model for censored length-biased data of prevalent cohort, Biometrika, 99: 995-1000; PMID: 23843676; PMCID: PMC3635658. 45. Deborah, D., Hughes, J., Wang, L., Chen, Y. Q. and Fleming, T. (2013) Study design considerations for evaluationg efficacy of systemix preexposure prophylaxis interventions. Journal of AIDS, 63: Supplement 2, S130-134; PMID: 23764624; PMCID: PMC3725298 46. Walensky, R., Ross, E., Kumarasamy, N, Wood, R., Noubary, F., Paltiel, D., Nakamura, Y., Godbole, S., Panchia, R., Sanne, I., Weinstein, M., Losina, E., Mayer, K., Chen, Y. Q., Wang, L., McCauley, M., Gamble, T., Seage, G. and Cohen, M. (2013) Cost-effectiveness of HIV treatment as prevention in serodiscordant couples. New England Journal of Medicine. 369: 1715-1725; PMID: 24171517; PMCID: PMC3913536. 47. Fogel, J. M., Wang L., Parsons, T. L., Ou S.-S., Piwowar-Manning, E., Chen, Y. Q., Mudhune, V. O., Hosseinipour, M. C., Kumwenda, J., Hakim, J. G., Chariyalertsak, S., Panchia, R., Sanne, I., Kumarasamy, N., Grinsztejn, B., Makhema, J., Pilotto, J., Santos, B. R., Mayer, K. H., McCauley, M., Gamble, T., Bumpus, N. N., Hendrix, C. W., Cohen, M. S., and Eshleman S. H. (2013) Undisclosed antiretroviral drug use in a multi-national clinical trial (HPTN 052). Journal of Infectious Diseases, 208 (10): 1624-1628; PMID: 23908493, PMCID: PMC3805242 48. Grant, S., Chen, Y. Q. and May, S. (2014) Performance of goodness-of-fit tests for the Cox proportional hazards model with time-varying covariates, Lifetime Data Analysis, 20:355-368; PMID: 23925703; PMCID: PMC3918489 49. Grinsztejn, B., Hosseinipour, M., Ribaudo, H., Swindells, S., Eron, J., Chen, Y. Q., Wang, L., Ou, S., Anderson, M., McCauley, M., Gamble, T., Kumarasamy, N., Hakim, J., Kumwenda, J., Pilotto, J., Godbole, S., Chariyalertsak, S., de Melo, M., Mayer, K., Eshleman, S., Piwowa-Manning, E., Makhema, J., Mills, L., Panchia, R., Sanne, I., Gallant, J., Hoffman, I., Taha, T., Mielsen-Saines, K., Celentano, D., Essex, M., Havlir, D., and Cohen, M. (2014) Effects of early versus delayed initiation of antiretroviral therapy on HIV clinical outcomes: results from the HPTN 052 trial. The Lancet Infectious Disease, 14(4): 281-290; PMID: 24602844; PMCID: PMC4144040

50. Saegusa, T., Di, C. and Chen, Y. Q. (2014) Hypothesis testing for an extended Cox model with time-varying coefficients, Biometrics, 70, 619-628; PMID: 24888739; PMCID: PMC4247822. 51. Safren, S. A., Mayer, K. H., Ou, S.-S., McCauley, M., Grinsztejn, B., Hosseinipour, M. C., Kumarasamy, N., Gamble, T., Hoffman, I., Celentano, D., Chen, Y. Q. and Cohen, M. S. (2015) Adherence to early antiretroviral therapy: Results from HPTN 052, a Phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples, Journal of AIDS, 1;69(2):234-40. PMCID: PMC4445420; PMID: 26009832. 52. Tang, Z., Lan, G., Chen, Y. Q., Zhu, Q., Yang, X., Shen, Z., Chen, Y., Zhang, H., Kan, W., Xing, H., Ruan, Y. and Shao, Y. (2015) HIV-1 Treatment-as-Prevention: a cohort study analysis of serodiscordant couples in rural southwest China. Medicine. 94(24): e902. PMCID: PMC4616551; PMID: 26091454. 53. Crouch, L., May, S. and Chen, Y. Q. (2016) Analysis of residual time quantiles under the Cox model. Lifetime Data Analysis, 22:299-319. PMCID: PMC4699877; PMID: 26058825. 54. Fogel, J. M., Hudelson, S. E., Ou, S.-S., Hart, S., Wallis, C., Morgado, M. G., Saravanan, S., Tripathy, S., Hovind, L., Piwowar-Manning, E., Sabin, D., McCauley, M., Gamble, T., Zhang, X.C., Eron, J. J., Gallant, J. E., Kumwenda, J., Makhema, J., Kumarasamy, N., Chariyalertsak, S., Hakim, H., Badal-Faesen, S., Akelo, V., Hosseinipour, M. C., Santos, B. R., Godbole, S. V., Pilotto, J. H., Grinsztejn, B., Panchia, R., Mayer, K. H., Chen, Y. Q., Cohen, M. S., and Eshleman, S. H. (2016) HIV drug resistance in adults failing early antiretroviral treatment: results from the HIV Prevention Trials Network 052 trial. Journal of AIDS, 72(3): 304-9. PMID: 26859828; PMCID: PMC4911290. 55. Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M., Kumarasamy, N., Hakim, J., Kumwenda, J., Grinsztejn, B., Pilotto, J., Godbole, S., Mehendale, S., Chariyalertsak, S., Santos, B., Mayer, K., Hoffman, I., Eshleman, S., Piwowar-Manning, E., Zhang, X., Makhema, J., Mills, L., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T., Nielsen, K., Celentano, D., Essex, M., Fleming, T., and the HPTN 052 Protocol Team (2016) Antiretroviral therapy for the prevention of HIV transmission. New England Journal of Medicine, 375: 830-839; PMID: 27424812. 56. Hanscom, B., Janes, H. E., Guarino, P. D., Huang, Y., Brown, E. R., Chen, Y. Q., Hammer, S. M., Gilbert, P. B., Donnell, D. J. (2016) Preventing HIV-1 infection in women using oral preexposure prophylaxis: a meta-analysis of current evidence. Journal of AIDS, 73(5): 606-608, PMID: 27552075. 57. Crouch, L., Zheng, C., and Chen, Y. Q. (2017) Estimating a treatment effect in residual time quantiles under the additive hazard model, Statistics in Biosciences, 9(1): 298-315. DOI: 10.1007/s12561-016-9180-x. PMID: 28694879. PMCID: PMC5501423. 58. Eshleman, S. H., Hudelson, S. E., Redd, A. D., Swanstrom, R., Ou, S.-S., Zhang, X. C., Ping, L. H., Piwowar-Manning, E., Porcella, S. F., Sievers, M. F., Martens, C. A., Bruno, D., Dukhovlinova, E., McCauley, M., Gamble, T., Fogel, J. M., Sabin, D., Quinn, T. C., Gunde, L., Maliwichi, M., Nhando, N., Akelo, V., Moyo, S., Panchia, R., Kumarasamy, N., Chotirosniramit, N., Gonçalves de Melo, M., Pilotto, J., Grinsztejn, B., Mayer, K., Chen, Y. Q., Hughes, J. P. and Cohen, M.S. (2017) Treatment as Prevention: characterization of partner infections in the HIV Prevention Trials Network 052 trial. Journal of AIDS; 74(1): 112-116, PMID: 27532476; PMCID: PMC5140698 59. Gulick, R. M., Wilkin, T. J., Chen, Y. Q., Landovitz, R. J., Amico, K. R., Young, A. M., Richardson, P., Marzinke, M. A., Hendrix, C. W., Eshleman, S. H., McGowan, I., Cottle, L. M., Andrade, A., Marcus, C., Klingman, K. L., Chegu, W., Rinehardt, A. R., Rooney, J. F., Andrew, P., Salata, R. A., Magnus, M., Farley, J. E., Liu, A., Frank, I., Ho, K., Santana, J., Stekler, J. D., McCauley, M., and Mayer, K. H. (2017) Phase 2 study of the safety and tolerability of Maraviroc-containing regimens to prevent HIV infection in men who has sex with men (MSM) (HPTN 069/ACTG A5305), Journal of Infectious Diseases; 215(2): 238-246. PMID: 27811319.

60. Gulick, R. M., Wilkin, T. J., Chen, Y. Q., Landovitz, R. J., Amico, K. R., Young, A. M., Richardson, P., Marzinke, M. A., Hendrix, C. W., Eshleman, S. H., McGowan, I., Cottle, L. M., Andrade, A., Marcus, C., Klingman, K. L., Chegu, W., Rinehardt, A. R., Rooney, J. F., Andrew, P., Salata, R. A., Magnus, M., Farley, J. E., Liu, A., Frank, I., Ho, K., Santana, J., Stekler, J. D., McCauley, M., and Mayer, K. H. (2017) Safety and tolerability of maraviroc-containing regimens to prevent HIV infection in women: a Phase 2 randomized trial. Annals of Internal Medicine, 167(6):384-393. DOI: 10.7326/M17-0520. PMID: 28828489. PMCID: PMC5667908. 61. Greer, A. E., Ou, S.-S., Wilson, E., Piwowar-Manning, E., Forman, M.S., McCauley, M., Gamble, T., Ruangyuttikarn, C., Hosseinipour, M., Kumarasamy, N., Nyirebda, M., Grinsztejn, B., Pilotto, J. H., Kosashunhanan, N., de Melo, M. G., Makhema, J., Akelo, V., Panchia, R., Badal-Faesen, S., Chen, Y. Q., Cohen, M.S., Eshleman, S. H.,Thio, C. L. and Valsamakis, A. (2017) A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multi-national clinical trial: HPTN 052, Journal of AIDS, 76(4):388-393. DOI: 10.1097/QAI.0000000000001511. PMID: 28749822. PMCID: PMC5659928. 62. Palumbo, P.J., Wilson, E.A., Piwowar-Manning, E., McCauley, M., Gamble, T., Kumwenda, N., Makhema, J., Kumarasamy, N., Chariyalertsak, S., Hakim, J.G., Hosseinipour, M.C., Gonçalves de Melo, M., Godbole, S.V., Pilotto, J.H., Grinsztejn, B., Panchia, R., Chen, Y.Q., Cohen, M.S., Eshleman, S.H., Fogel,, J.M. (2017) Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS One, 12(5): e0177281, DOI: 10.1371/journal.pone.0177281. PMID: 28481902 PMCID: PMC542178. 63. Eshleman, S. H., Wilson, E. A., Zhang, X., Ou, S.-S., Piwowar-Manning, E., Eron, J.J., McCauley, M., Gamble, T.,Gallant, J. E., Hosseinipour, M., Kumarasamy, N., Hakim, J. G.,, Kalonga, E., Pilotto, J., Grinsztejn, B., Godbole, S. V., Chotirosniramit, N.,Santos, B. R., Shava, E., Mills, L. A., Panchia, R., Mwelase, N.,Mayer, K., Chen, Y. Q., Cohen, M.S. and Fogel, J. M.(2017) Virologic outcomes in early antiretroviral treatment: HPTN 052. HIV Clinical Trials; 18(3):100-109. DOI: 10.1080/15284336.2017.1311056. PMID: 28385131. PMCID: PMC5633001. 64. Zhao, W., Chen, Y. Q. and Hsu, L. (2017) On estimation of time-dependent population attributable fraction in population-based case-control studies, Biometrics, 73(3), 866-875, DOI: 10.1111/biom.12648. PMID: 28099992 PMCID: PMC5515699. 65. Limaye, A. P., Stapleton, R. D., Peng, L., Gunn, S. R., Kimball, L. E., Hyzy, R., Exline, M. C., Files, D. C., Morris, P. E., Frankel, S. K., Mikkelsen, M. E., Hite, D., Enfield, K. B., Steingrub, J., O’Brien, J., Parsons, P. E., Cuschieri, J., Wunderink, R.,G. Hotchkin, D. L., Chen, Y. Q., Rubenfeld, G. D., Boeckh, M. (2017) Effect of Ganciclovir on IL-6 levels among cytomegalovirus-Seropositive adults with critical illness: a randomized clinical trial, Journal of American Medical Association, 318(8):731-740. DOI: 10.1001/jama.2017.10569. PMID: 28829877. 66. Chen, Y. Q., Dale, R. D., He, H., and Le, Q.-A. T. (2017) Posterior estimates of dynamic constants in HIV transmission modeling. Computational and Mathematical Methods in Medicine, DOI: 10.1155/2017/1093045. Epub 2017 Nov 7. PMID: 29250132 PMCID: PMC5698610 67. Palumbo, P. J., Fogel, J. M., Hudelson, S. E., Wilson, E. A., Hart, S., Hovind, L., Piwowar- Manning, E., Wallis, C., Papathanasopoulos, M. A., Morgado, M. G., Saravanan, S., Tripathy, S., Eron, J. J., Gallant, J. E., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., Hakim, J. G., Pilotto, J. H., Kumwenda, J., Akelo, V., Godbole, S. V., Santos, B. R., Grinsztejn, B., Panchia, R., Chariyalertsak, S., Makhema, J., Badal-Faesen, S., Chen, Y. Q., Cohen, M. S., Eshleman, S. H. (2018) HIV drug resistance in adults receiving early versus delayed antiretroviral therapy: HPTN 052. Journal of AIDS. 77(5): 484-491. doi: 10.1097/QAI.0000000000001623. PMID: 29293156 PMCID: PMC5844834. 68. Zhang, Y., Fogel, J.M., Guo, X., Clarke, W., Breaud, A., Cummings, V., Hamilton, E. L., Ogendo, A., Kayange, N., Panchia, R., Dominguez, K., Chen, Y.Q., Sandfort. T., Eshleman, S.H. (2018) Antiretroviral drug use and HIV drug resistance among men who have sex with men and

transgender women in sub-Saharan Africa: HPTN 075 study. AIDS. 6/2018; 32(10):1301-1306 [PMC: In Process]. 69. McGowan, I., Wilkin, T., Landovitz, R. J., Wu, C., Chen, Y. Q., Marzinke, M. A., Hendrix, C. W., Richardson, P., Eshelman, S. H., Andrade, A., Chege, W., Anderson, P. L., McCauley, M., Farley, J., Mayer, K. H., Anton, P., Brand, R. M., Cranston, R. D., Gulick, R. (2018) The Pharmacokinetics, Pharmacodynamics, and Mucosal Responses to Maraviroc-Containing PrEP Regimens in Men who have Sex with Men. AIDS, in press. 70. Wheeler, D., Lucas, J., Wilton, L., Nelson, L., Hucks-Ortiz, C., Watson, C., Hutchinson, C., Mayer, K., Kuo, I., Magnus, M., Beauchamp, G., Shoptaw, S., Emel, L., Chen, Y. Q., Hightow- Weidman, L., Fields, S. (2018) Building Effective Multi-level HIV Prevention Partnerships with Black Men Who Have Sex with Men: Experience from HPTN073, a Pre-Exposure Prophylaxis study in 3-US cities. Journal of the International AIDS Society, in press. DOI: 10.1002/jia2.25180 71. De Dieu Tapsoba, J., Wang, C.-Y., Zangenah, S., and Chen, Y. Q. (2018) Generalized change- point models with application to HIV-surveillance data, Statistics in Medicine, in revision. 72. Zheng, W. and Chen, Y. Q. (2017) Estimating relative risk in an expanded Cox proportional hazards model with time-varying covariates, Biometrics, in revision. 73. Othus, M., Zhang, X., Chen, C.-H. and Chen, Y. Q. (2017) Regression analysis of residual life with a long-term survival fraction, Lifetime Data Analysis, in revision. 74. Zheng, C. and Chen, Y. Q. (2017) On a shape-invariant hazard regression model, Lifetime Data Analysis, in revision. 75. Hu, J., Wang, Y., and Chen, Y. Q. (2017) Semiparametric estimation of a scale-change in expectancy regression. Biometrika, in revision. 76. Smith, M. and Chen, Y. Q. (2017) Maximum likelihood estimation of time to endpoint accrual in monitoring clinical trials, Journal of the Royal Statistical Society, Series C, in revision. 77. Chen, Y. Q., Zhang, X. and Prentice, R. (2017) On measuring functional attribution. Journal of the American Statistical Association, in revision. 78. Chen, Y. Q., Hsu, L., Zhang, X. and Peters, U. (20167 Measuring public health impact of exposures by population attributable risk and population attributable benefit. Epidemiology, in revision. 79. Zhang, X., and Chen, Y. Q. (2017) On a dual parameter of the population attributable risk. Statistics in Medicine, in revision. 80. Zhuang, R. and Chen, Y. Q. (2017) Measuring marker’s surrogacy in randomized clinical trials, Biometrics, submitted. 81. Wang, Y. and Chen, Y. Q. (2017) Attributable excess-time function for censored time-to-event data, Biometrics, submitted. 82. Zhang, X., Zheng, W. and Chen, Y. Q. (2017) Population Attributable Fractions under Additive Models. Statistics in Medicine, in preparation.

Other published work: 1. Gaffikin, L., McGrath, J., Chen, Y. Q., Walter, S. (1998) Effect of verification bias on the test qualities of visual inspection for cervical cancer screening: Zimbabwe case study, Poster to the Conference of the American Public Health Association, Washington, D.C., 1998. 2. Munoz, A., Lyles, R., Margolick, J., Giorgi, J., Chen, Y. Q., Phir, J., Mellors, J. (1998) HIV- RNA and CD4+ decline without therapy: reference values to gauge effectiveness of antiretrovirals, Poster (No. 12127) to the 4th AIDS World Conference, Geneva. 3. Chirenji, Z. M., Chipato, T., Kasule, J., Rusakaniko, S., Makunike, R., Ngwalle, E., Gaffikin, L., Blumethal, P. D., McGrath, J., Sanghvi, H., Brechin, S. J. G., Chen, Y. Q. (1999) Visual inspection as a means of primary testing for cervical cancer: results from a large-scale study in Zimbabwe, JHPIEGO Technical Report, JHP-05.

4. Chen, Y. Q., Wang, M.-C., Eaton, W. (2001) Detection of progressive deterioration in early onset schizophrenia with a new statistical method, UC Berkeley Biostatistics Technical Report 102. 5. Chasela, C., Hoffman, I., Chen, Y. Q., Valentine, M., Brown, E., Read, J., Chilogozi, D., Martinson, F., Wang, L., Fiscus, S. A. (2006) Late postnatal transmission of HIV-1 according to geographic location in sub-Saharan Africa: HPTN 024. Poster to the 13th Conference on Retroviruses and Opportunistic Infections, Denver. 6. Godbole, S., Kumarasamy, N., Chen, Y. Q., Chariyalertsak, S., Hakim, J., Santos, B., Grinsztejn, B., Pilotto, J., Hosseinipour, M., Kumwenda, J., Sanne1, I., McCauley, M., Gamble, T., Filho, E., Mayer, K., Cohen, M., and the HPTN 052 Protocol Team (2008) Antiretroviral Therapy to Prevent the Sexual Transmission of HIV-1: Initial Results from HPTN 052. Poster to the XVII International AIDS Conference, Mexico City. 7. Cohen, M., Chen, Y. Q., McCauley, M., Gamble, T., Bollinger, R., Bryson, Y., Burns, D., Celentano, D., Chariyalertsak, S., Conradie, F., Cottle, L., de Bruyn, G., Elharrar, V., Eshelman, S., Essex, M., Filho, E. C. J., Godbole, S., Grinsztejn, B., Hakim, J. G., Hoffman, I. F., Hosseinipour, M., Kumwenda, J., Makhema, J., Martinez, A., Mayer, K. H., Mehendale, S., Mills, L. A., Nielsen, K.A.-H., Pilotto, J.H.d.S., Piwowar-Manning, E., Sanne, I., Santos, B. R., Taha, T., Wang, L., Safren, S., Fleming, T., and HPTN052 Protocol Team (2011), Antiretroviral treatment to prevent the sexual transmission of HIV-1: results from the HPTN 052 multinational randomized controlled trial. Poster to the 6th IAS Conference on HIV Pathogenesis, Rome, Italy. 8. Hughes, J., Hudelson, S., Redd, A., Wang, L., Debes, R., Chen, Y. Q., Porcella, S., Piwowar- Manning, E., McCauley, M., Hosseinipour, M., Kumwenda, J., Hakim, J., Chariyalertsak, S., de Bruyn, G., Grinsztejn, B., Kumarasamy, N., Makhema, J., Mayer, K., Pilotto, J., Santos, B., Quinn, T., Cohen, M., Eshleman, S., and HPTN052 Protocol Team (2011), Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network (HPTN) 052 trial. Poster to the 6th IAS Conference on HIV Pathogenesis, Rome, Italy. 9. Hosseinipour, M. C., Wang, L., Cohen, M., Chariyalertsak, S., Chen, Y. Q., Elharrar, V., Eshleman, S., Gallant, J., Gamble, T., Godbole, S., Govinder, S., Grinsztejn, B., Hakim, J.G., Havlir, D., Ive, P., Klingman, K., Kumarasamy, N., Kumwenda, J., Makhema, J., Mayer, K., McCauley, M., Mills, L., Pilotto, J., Piwowar-Manning, E., Ribaudo, H., Santos, B. R., Swindells, S., Eron, J. J., and the HPTN 052 Protocol Team (2011), Immunologic and virologic disease progression and responses to ART across geographic regions: outcomes from HPTN 052 study. Poster to the 6th IAS Conference on HIV Pathogenesis, Rome, Italy. 10. Grinsztejn, B., Ribaudo, H., Cohen, M., Swindells, S., Badel-Faesen, S., Burns, D., Chariyalertsak, S., Chen, Y. Q., de Bruyn, G., Eron, J.J., Eshleman, S., Fleming, T., Gallant, J., Gamble, T., Godbole, S. V., Hakim, J. G., Hosseinipour, M. C., Klingman, K., Kumarasamy, N., Kumwenda, J., Makhema, J., Mayer, K., McCauley, M., Mills, L. A., Pilotto, J. H., Piwowar- Manning, E., Santos, B. R., Wang, L., Havlir, D., and the HPTN 052 Protocol Team (2011), Effects of early versus delayed initiation of antiretroviral therapy (ART) on HIV clinical outcomes: results from the HPTN 052 randomized clinical trial. Poster to the 6th IAS Conference on HIV Pathogenesis, Rome, Italy.

Teaching History1

Classroom Teaching

Course/Title (Credit) Semester/Quarter JHSPH 140.606.11: Survival Analysis (3) Summer 1999 Summer 2009

1 JHSPH: Johns Hopkins School of Public Health; UCB, UC Berkeley; UW, University of Washington 15

UCB PH 240A: Biostatistical Methods: Risk Research Methods (4) Fall 1999 Fall 2001 UCB PH 243B: Advanced Generalized Linear Model (4) Spring 2000 Spring 2002 UCB PH 243A: Special Topic: Exploratory Data Analysis (4) Fall 2000 UCB PH 246B: Exploratory Data Analysis (4) Fall 2002 UCB PH 243B: Special Topics: Pharmaceutical Statistics (4) Spring 2003 UW BIOST 576A: Advanced Survival Analysis (3) Spring 2007 Spring 2009

Independent Study

UW BIOST: 600 Independent Study Nan Hu Autumn 2007 - Spring 2010 Takumi Saegusa Autumn 2010 - Spring 2011 Erin Gabriel Winter 2011 Megan Smith, Wei Zhao Spring 2011 - Fall 2011 Cheng Zheng Fall 2011 - Spring 2012 Luis Alexander Crouch Fall 2011 Wenying Zheng Spring 2012 - Fall 2012 Rui Zhuang Fall 2015 - Present Xiaoyue Wang Fall 2017 - Summer 2018 UW BIOST 800: Doctoral Dissertation Kenneth Wu Winter 2007 - Spring 2011 Luis Alexander Crouch Winter 2012 - Spring 2014 Wei Zhao (Co-advisor: Li Hsu) Winter 2012 - Fall 2014 Megan Smith Fall 2011 - Fall 2014 Wenying Zheng Spring 2013 - 2016