bioRxiv preprint doi: https://doi.org/10.1101/244129; this version posted April 24, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Title 2 Ribosome provisioning activates a bistable switch coupled to fast exit from stationary 3 phase 4 5 Authors: 6 P. Remigi1*, G.C. Ferguson2, S. De Monte3,4 and P.B. Rainey1,5,6* 7 1 New Zealand Institute For Advanced Study, Massey University, AucKland 0745, New 8 Zealand 9 2 Institute oF Natural and Mathematical Sciences, Massey University, AucKland 0745, New 10 Zealand 3 11 Institut de biologie de l’Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, 12 INSERM, PSL Université Paris 75005 Paris, France 13 4 Department oF Evolutionary Theory, Max PlancK Institute For Evolutionary Biology, Plön 14 24306, Germany 15 5 Department oF Microbial Population Biology, Max PlancK Institute For Evolutionary Biology, 16 Plön 24306, Germany 6 17 Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris 18 Tech), CNRS UMR 8231, PSL Research University, 75231 Paris, France 19 20 * Corresponding authors: 21 Philippe Remigi (
[email protected]) and Paul B. Rainey (
[email protected]) 22 bioRxiv preprint doi: https://doi.org/10.1101/244129; this version posted April 24, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 23 Abstract: 24 Observations oF bacteria at the single-cell level have revealed many instances oF phenotypic 25 heterogeneity within otherwise clonal populations, but the selective causes, molecular bases 26 and broader ecological relevance remain poorly understood.