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Telazol® CIII(Tiletamine and Zolazepam for Injection)
TELAZOL- tiletamine hydrochloride and zolazepam hydrochloride injection, powder, for solution Zoetis Inc. ---------- Telazol® CIII (tiletamine and zolazepam for injection) 100 mg/mL total (equivalent to 50 mg/mL tiletamine and 50 mg/mL zolazepam) For Intramuscular and Intravenous injection in Dogs For Intramuscular injection only in Cats CAUTION Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION TELAZOL (tiletamine and zolazepam for injection) is a nonnarcotic, nonbarbiturate, injectable anesthetic agent for dogs and cats. Chemically, TELAZOL is a combination of equal parts by weight of base of tiletamine hydrochloride (2-[ethylamino]-2-[2-thienyl]-cyclohexanone hydrochloride), an arylaminocycloalkanone dissociative anesthetic, and zolazepam hydrochloride (4-[o-fluorophenyl]-6, 8-dihydro-1,3,8- trimethylpyrazolo [3, 4-e][1,4] diazepin-7 [1H]-1- hydrochloride), a nonphenothiazine diazepinone having minor tranquilizing properties. The product is supplied sterile in vials. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. This solution has a pH of 2 to 3.5 and is recommended for deep intramuscular injection. INDICATIONS Dogs TELAZOL is indicated in dogs for restraint and minor procedures of short duration (30 min. avg.) requiring mild to moderate analgesia. Minor surgery is considered to be laceration repair, draining of abscesses, castrations and other procedures requiring mild to moderate analgesia. (See Dogs under Dosage and Administration.) TELAZOL administered intravenously is indicated in dogs for induction of anesthesia followed by maintenance with an inhalant anesthetic. Cats TELAZOL is indicated in cats for restraint or for anesthesia combined with muscle relaxation. -
Veterinary Anesthetic and Analgesic Formulary 3Rd Edition, Version G
Veterinary Anesthetic and Analgesic Formulary 3rd Edition, Version G I. Introduction and Use of the UC‐Denver Veterinary Formulary II. Anesthetic and Analgesic Considerations III. Species Specific Veterinary Formulary 1. Mouse 2. Rat 3. Neonatal Rodent 4. Guinea Pig 5. Chinchilla 6. Gerbil 7. Rabbit 8. Dog 9. Pig 10. Sheep 11. Non‐Pharmaceutical Grade Anesthetics IV. References I. Introduction and Use of the UC‐Denver Formulary Basic Definitions: Anesthesia: central nervous system depression that provides amnesia, unconsciousness and immobility in response to a painful stimulation. Drugs that produce anesthesia may or may not provide analgesia (1, 2). Analgesia: The absence of pain in response to stimulation that would normally be painful. An analgesic drug can provide analgesia by acting at the level of the central nervous system or at the site of inflammation to diminish or block pain signals (1, 2). Sedation: A state of mental calmness, decreased response to environmental stimuli, and muscle relaxation. This state is characterized by suppression of spontaneous movement with maintenance of spinal reflexes (1). Animal anesthesia and analgesia are crucial components of an animal use protocol. This document is provided to aid in the design of an anesthetic and analgesic plan to prevent animal pain whenever possible. However, this document should not be perceived to replace consultation with the university’s veterinary staff. As required by law, the veterinary staff should be consulted to assist in the planning of procedures where anesthetics and analgesics will be used to avoid or minimize discomfort, distress and pain in animals (3, 4). Prior to administration, all use of anesthetics and analgesic are to be approved by the Institutional Animal Care and Use Committee (IACUC). -
Introduced B.,Byhansen, 16
LB301 LB301 2021 2021 LEGISLATURE OF NEBRASKA ONE HUNDRED SEVENTH LEGISLATURE FIRST SESSION LEGISLATIVE BILL 301 Introduced by Hansen, B., 16. Read first time January 12, 2021 Committee: Judiciary 1 A BILL FOR AN ACT relating to the Uniform Controlled Substances Act; to 2 amend sections 28-401, 28-405, and 28-416, Revised Statutes 3 Cumulative Supplement, 2020; to redefine terms; to change drug 4 schedules and adopt federal drug provisions; to change a penalty 5 provision; and to repeal the original sections. 6 Be it enacted by the people of the State of Nebraska, -1- LB301 LB301 2021 2021 1 Section 1. Section 28-401, Revised Statutes Cumulative Supplement, 2 2020, is amended to read: 3 28-401 As used in the Uniform Controlled Substances Act, unless the 4 context otherwise requires: 5 (1) Administer means to directly apply a controlled substance by 6 injection, inhalation, ingestion, or any other means to the body of a 7 patient or research subject; 8 (2) Agent means an authorized person who acts on behalf of or at the 9 direction of another person but does not include a common or contract 10 carrier, public warehouse keeper, or employee of a carrier or warehouse 11 keeper; 12 (3) Administration means the Drug Enforcement Administration of the 13 United States Department of Justice; 14 (4) Controlled substance means a drug, biological, substance, or 15 immediate precursor in Schedules I through V of section 28-405. 16 Controlled substance does not include distilled spirits, wine, malt 17 beverages, tobacco, hemp, or any nonnarcotic substance if such substance 18 may, under the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. -
Outline for Controlled Substances Program
Environmental Health and Safety Controlled Substances Program Date of Issuance: Review Date: 10/1/2019 (no changes) 10/01/2018 Revision Number: Initial Prepared by: EH&S Table of Contents HEADINGS Introduction Applicability Responsibilities Registration Requirements Authorized Use Ordering/Purchasing Administering and Dispensing Inventory Procedures (Continuing Records) Security Disposal FORMS: Registering or renewing a DEA or state license (CMU) Controlled Substances Authorized users list (CMU) Employee questionnaire for those with access to controlled substances (CMU) Record of Form 222 use (Order form) (CMU) Records of Controlled Substance Purchases (CMU) Record of Controlled Substance Administering and dispensing (CMU) Controlled Substance Physical Inventory (CMU) DEA Registration of Persons doing research or analysis (Form 225) DEA Registration of Dispensers (Form 224) DEA Registration Instructional (Form 224 and 226 to renew) DEA Report of loss or theft (Form 106) DEA Report of drugs surrendered (From 41) DEA SCHEDULES: Schedule I Schedule II Schedule III Schedule IV Schedule V INTRODUCTION State and Federal regulations have been promulgated concerning the use and handling of US Department of Justice Drug Enforcement Administration (DEA) controlled substances. These regulations are in place to address materials which are or have the potential to be addictive or habit forming. These substances have been categorized into “schedules” that have been created by the DEA to reflect their level of concern. The “Carnegie Mellon University DEA Controlled Substances Program” is intended to ensure that Carnegie Mellon University is in compliance with our regulatory requirements. Required activities under the DEA include: 1. Registration of your work with the DEA and with Carnegie Mellon’s Department of Environmental Health and Safety (EH&S). -
Tennessee Drug Statutes (Listed in Numerical Order)
Tennessee Drug Statutes (listed in numerical order) 39-17-405. Criteria for Schedule I. • The commissioner of mental health and substance abuse services, upon the agreement of the commissioner of health, shall place a substance in Schedule I upon finding that the substance has: o (1) High potential for abuse; and o (2) No accepted medical use in treatment in the United States or lacks accepted safety for use in treatment under medical supervision. 39-17-406. Controlled substances in Schedule I. • (a) Schedule I consists of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. • (b) Opiates, unless specifically excepted or unless listed in another schedule, means any of the following opiates, including their isomers, esters, ethers, salts and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation. For the purposes of subdivision (b)(34) only, the term isomer includes the optical and geometric isomers. o (1) Acetyl-alpha-methylfentanyl (N-[1-(1-methyl-2-phenethyl)-4- piperidinyl]-N-phenylacetamide); o (2) Acetylmethadol; o (3) Allylprodine; o (4) Alphacetylmethadol (except levo-alphacetylmethadol also known as levo-alpha-acetylmethadol; levomethadyl acetate; or LAAM); o (5) Alphameprodine; o (6) Alphamethadol; o (7) Alpha-methylfentanyl (N-[1-(alpha-methyl-beta-phenyl)ethyl-4- piperidyl]propionanilide; 1-(1-methyl-2-phenylethyl)-4-(N- propanilido)piperidine; -
Drug Enforcement Administration, Justice § 1308.13
Drug Enforcement Administration, Justice § 1308.13 (2) Methamphetamine, its salts, (ii) 1- isomers, and salts of its iso- piperidinocyclohexanecarboni- mers ........................................ 1105 trile (PCC) ............................... 8603 (3) Phenmetrazine and its salts 1631 (3) Immediate precursor to fentanyl: (4) Methylphenidate ................... 1724 (5) Lisdexamfetamine, its salts, (i) 4-anilino-N-phenethyl-4-pi- isomers, and salts of its iso- peridine (ANPP) ...................... 8333 mers ........................................ 1205. (ii) [Reserved] (e) Depressants. Unless specifically [39 FR 22142, June 20, 1974] excepted or unless listed in another EDITORIAL NOTE: For FEDERAL REGISTER ci- schedule, any material, compound, tations affecting § 1308.12, see the List of CFR mixture, or preparation which contains Sections Affected, which appears in the any quantity of the following sub- Finding Aids section of the printed volume stances having a depressant effect on and at www.fdsys.gov. the central nervous system, including its salts, isomers, and salts of isomers § 1308.13 Schedule III. whenever the existence of such salts, (a) Schedule III shall consist of the isomers, and salts of isomers is possible drugs and other substances, by what- within the specific chemical designa- ever official name, common or usual tion: name, chemical name, or brand name (1) Amobarbital .......................... 2125 designated, listed in this section. Each (2) Glutethimide ......................... 2550 drug or substance has been -
Tiletamine-Zolazepam Anesthesia in North American River Otters (Lutra Canadensis) and Its Partial Antagonism with Flumazenil
]OUf7/U[ (~rZOO and Wild/~re M(>dicine 28(4): 418-423,1997 Copyright 1997 by American Association of Zoo Veterinarians TILETAMINE-ZOLAZEPAM ANESTHESIA IN NORTH AMERICAN RIVER OTTERS (LUTRA CANADENSIS) AND ITS PARTIAL ANTAGONISM WITH FLUMAZENIL Lucy H. Spelman, D.V.M., Perry W. Sumner, M.S., William B. Karesh, D.V.M., and Michael K. Stoskopf, D.V.M., Ph.D. Abstract: North American river otters (Lutra canadensis) were anesthetized with tiletamine-zolazepam or tiletamine zolazepam-flumazenil combinations in cooperation with the North Carolina Wildlife Resources Commission Otter Restoration Project for evaluation of physiologic changes during anesthesia. Sixteen otters received tiletamine-zolaze pam (4 mg/kg combined, i.m.) in 1994. Induction and recovery times were recorded and physiologic data (heart rate and rhythm, respiratory rate, rectal temperature, relative oxyhemoglobin saturation, and mean arterial blood pressure) were collected at 5-min intervals. Respiratory depression developed initially in all otters, and median relative oxyhe moglobin saturation remained below 90% for the first 15 min of anesthesia. Anesthetic induction with tiletamine zolazepam was rapid and smooth, but recovery was prolonged (median = 89 min) and characterized by persistent head motion. In 1995, flumazenil was evaluated as a partial antagonist for tiletamine-zolazepam anesthesia in otters. Sixteen otters were anesthetized with tiletamine-zolazepam (4 mg/kg combined, i.m.) and given flumazenil (I mg per 25 mg of zolazepam) after 20 min. Flumazenil markedly shortened recovery time in all otters anesthetized with tiletamine zolazepam (median = 65 min) with no adverse effects. Key words: River otter, Lutra canadensis, anesthesia, tiletamine-zolazepam, flumazenil. INTRODUCTION ratory depression produced by diazepam and mid 7 9 azolam.4. -
Laws 2021, LB236, § 4
LB236 LB236 2021 2021 LEGISLATIVE BILL 236 Approved by the Governor May 26, 2021 Introduced by Brewer, 43; Clements, 2; Erdman, 47; Slama, 1; Lindstrom, 18; Murman, 38; Halloran, 33; Hansen, B., 16; McDonnell, 5; Briese, 41; Lowe, 37; Groene, 42; Sanders, 45; Bostelman, 23; Albrecht, 17; Dorn, 30; Linehan, 39; Friesen, 34; Aguilar, 35; Gragert, 40; Kolterman, 24; Williams, 36; Brandt, 32. A BILL FOR AN ACT relating to law; to amend sections 28-1202 and 69-2436, Reissue Revised Statutes of Nebraska, and sections 28-401 and 28-405, Revised Statutes Cumulative Supplement, 2020; to redefine terms, change drug schedules, and adopt federal drug provisions under the Uniform Controlled Substances Act; to provide an exception to the offense of carrying a concealed weapon as prescribed; to define a term; to change provisions relating to renewal of a permit to carry a concealed handgun; to provide a duty for the Nebraska State Patrol; to eliminate an obsolete provision; to harmonize provisions; and to repeal the original sections. Be it enacted by the people of the State of Nebraska, Section 1. Section 28-401, Revised Statutes Cumulative Supplement, 2020, is amended to read: 28-401 As used in the Uniform Controlled Substances Act, unless the context otherwise requires: (1) Administer means to directly apply a controlled substance by injection, inhalation, ingestion, or any other means to the body of a patient or research subject; (2) Agent means an authorized person who acts on behalf of or at the direction of another person but does not include a common or contract carrier, public warehouse keeper, or employee of a carrier or warehouse keeper; (3) Administration means the Drug Enforcement Administration of the United States Department of Justice; (4) Controlled substance means a drug, biological, substance, or immediate precursor in Schedules I through V of section 28-405. -
21 CFR Ch. II (4–1–01 Edition) § 1308.11
§ 1308.11 21 CFR Ch. II (4–1–01 Edition) and on certain order forms issued by (4) Alphacetylmethadol (except levo- the Administration pursuant to alphacetylmethadol also known as levo-alpha- acetylmethadol, levomethadyl acetate, or LAAM) ..... 9603 § 1305.05(d) of this chapter. Applicants (5) Alphameprodine ....................................................... 9604 for procurement and/or individual man- (6) Alphamethadol ......................................................... 9605 ufacturing quotas must include the ap- (7) Alpha-methylfentanyl (N-[1-(alpha-methyl-beta- propriate code number on the applica- phenyl)ethyl-4-piperidyl] propionanilide; 1-(1-methyl- 2-phenylethyl)-4-(N-propanilido) piperidine) ............... 9814 tion as required in §§ 1303.12(b) and (8) Alpha-methylthiofentanyl (N-[1-methyl-2-(2- 1303.22(a) of this chapter. Applicants thienyl)ethyl-4-piperidinyl]-N-phenylpropanamide) ..... 9832 for import and export permits must in- (9) Benzethidine ............................................................. 9606 (10) Betacetylmethadol .................................................. 9607 clude the appropriate code number on (11) Beta-hydroxyfentanyl (N-[1-(2-hydroxy-2- the application as required in phenethyl)-4-piperidinyl]-N-phenylpropanamide) ....... 9830 §§ 1312.12(a) and 1312.22(a) of this chap- (12) Beta-hydroxy-3-methylfentanyl (other name: N-[1- ter. Authorized registrants who desire (2-hydroxy-2-phenethyl)-3-methyl-4-piperidinyl]-N- phenylpropanamide .................................................... 9831 -
TILETAMINE Hcl and ZOLAZEPAM
General Dosing Information Fasting prior to induction of general anesthesia with TELAZOL is not essential; however, when preparing for elective surgery, it is advisable to withhold food for at least 12 hours prior to TELAZOL administration. As with other injectable anesthetic agents, the individual response to TELAZOL is somewhat varied, depending upon the dose, general physical condition and age of the patient, duration of the surgical procedure, and any preanesthetics (TILETAMINE(tiletamine and HCl zolazepam for injection) used. Therefore, recommendations for dosage regimens cannot be fixed absolutely. Specific 100 mg/mL total and ZOLAZEPAM HCl) dosage requirements must be determined by evaluation of the health status and condition (equivalent to 50 mg/mL tiletamine and 50 mg/mL zolazepam) of the patient and of the procedure to be performed. For Intramuscular and Intravenous injection in Dogs Recovery varies with the age and physical condition of the animal and the dose of TELAZOL For Intramuscular injection only in Cats administered. Recovery is extended with high dose or multiple injections, particularly in cats. CAUTION Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Intramuscular injection in dogs and cats: There may be pain on injection. This is especially prevalent in cats. DESCRIPTION Following a single, deep intramuscular injection of TELAZOL in cats and dogs, onset of TELAZOL (tiletamine and zolazepam for injection) is a nonnarcotic, nonbarbiturate, anesthetic effect usually occurs within 5 to 12 minutes. Muscle relaxation is optimum injectable anesthetic agent for dogs and cats. Chemically, TELAZOL is a combination of for approximately the first 20 to 25 minutes after TELAZOL is administered, and then equal parts by weight of base of tiletamine hydrochloride (2-[ethylamino]-2-[2-thienyl]- diminishes. -
SB0170S01* Money Appropriated in This Bill: Other Special Clauses: Utah Code Sections Af AMENDS: Administration and Contain a Component of Cannabis
LEGISLATIVE GENERAL COUNSEL S.B. 170 6 Approved for Filing: D.M. Cheung 6 1st Sub. (Green) 6 02-19-19 8:19 AM 6 Senator Evan J. Vickers proposes the following substitute bill: 1 PHARMACY AND PHARMACEUTICALS AMENDMENTS 2 2019 GENERAL SESSION 3 STATE OF UTAH 4 Chief Sponsor: Evan J. Vickers 5 House Sponsor: Brad M. Daw 6 7 LONG TITLE 8 General Description: 9 This bill amends provisions relating to the practice of pharmacy. 10 Highlighted Provisions: 11 This bill: 12 < amends the definition of º "closed door pharmacy" and » "practice as a licensed 12a pharmacy technician"; 13 < adds a drug to the list of long-acting injectable drug therapies that can be 14 administered by certain pharmacists; 15 < changes the requirements for certain supervising pharmacists; 16 < adds certain board certified urologists to the list of individuals who are qualified to 17 be a dispensing medical practitioner; and 18 < reschedules certain drugs that are approved by the United States Food and Drug 1 19 Administration and contain a component of cannabis. s t 20 Money Appropriated in this Bill: S 21 None u b 22 Other Special Clauses: . S 23 None . B 24 Utah Code Sections Affected: . 25 AMENDS: 1 7 0 *SB0170S01* - 1 - House Committee Amendments 3-5-2019 pf/dc 1st Sub. (Green) S.B. 170 02-19-19 8:19 AM 26 58-17b-102, as last amended by Laws of Utah 2018, Chapter 295 27 58-17b-612, as last amended by Laws of Utah 2014, Chapter 72 28 58-17b-625, as enacted by Laws of Utah 2017, Chapter 384 29 58-17b-805, as enacted by Laws of Utah 2014, Chapter 72 30 58-37-4, as last amended by Laws of Utah 2018, Chapter 146 31 32 Be it enacted by the Legislature of the state of Utah: 33 Section 1. -
Drug/Substance Trade Name(S)
A B C D E F G H I J K 1 Drug/Substance Trade Name(s) Drug Class Existing Penalty Class Special Notation T1:Doping/Endangerment Level T2: Mismanagement Level Comments Methylenedioxypyrovalerone is a stimulant of the cathinone class which acts as a 3,4-methylenedioxypyprovaleroneMDPV, “bath salts” norepinephrine-dopamine reuptake inhibitor. It was first developed in the 1960s by a team at 1 A Yes A A 2 Boehringer Ingelheim. No 3 Alfentanil Alfenta Narcotic used to control pain and keep patients asleep during surgery. 1 A Yes A No A Aminoxafen, Aminorex is a weight loss stimulant drug. It was withdrawn from the market after it was found Aminorex Aminoxaphen, Apiquel, to cause pulmonary hypertension. 1 A Yes A A 4 McN-742, Menocil No Amphetamine is a potent central nervous system stimulant that is used in the treatment of Amphetamine Speed, Upper 1 A Yes A A 5 attention deficit hyperactivity disorder, narcolepsy, and obesity. No Anileridine is a synthetic analgesic drug and is a member of the piperidine class of analgesic Anileridine Leritine 1 A Yes A A 6 agents developed by Merck & Co. in the 1950s. No Dopamine promoter used to treat loss of muscle movement control caused by Parkinson's Apomorphine Apokyn, Ixense 1 A Yes A A 7 disease. No Recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. It is often claimed that BZP was originally Benzylpiperazine BZP 1 A Yes A A synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals.