APOA2, Human Recombinant

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FOR RESEARCH ONLY! Apolipoprotein A-II / APOA2, Human Recombinant CATALOG #: P1383-50 P1383-10 AMOUNT: 50 µg 10 µg Apolipoprotein A-II, APOA2, Apo-AII, ApoA-II, Apolipoprotein A2 ALTERNATE NAMES: MOL. WT. This protein carries a 6x His tag at the C-terminus. The protein has a calculated MW of 11.2 kDa. The protein migrates as 11 kDa and 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. SOURCE: E.coli PURITY: >90% as determined by SDS-PAGE. ENDOTOXIN: Less than 1.0 EU per μg by the LAL method. FORM: Lyophilized FORMULATION: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of100 µg/ml. RECONSTITUTION: Do not vortex. It is recommended to store at -20°C. STORAGE CONDITIONS: Store at -20°C. After reconstitution, aliquot and store at -20°C and use within 3 months. Avoid repeated freezing and thawing cycles. DESCRIPTION: Apolipoprotein A-II(APO-A2) stabilize HDL (high density lipoprotein) structure by its association with lipids and affect the HDL metabolism. It is produced by the liver and is involved in cholesteryl ester formation and cholesterol transport from tissues to the liver. Recent studies have established the interaction between APOA2 -256T>C polymorphism and dietary saturated fatty acids intake in relation to obesity on healthy individuals. The significant interaction between APOA2-saturated fatty acids intake and body mass index (BMI). AMINO ACID SEQUENCE: AA Ala 19 - Gln 100 Human Apolipoprotein A-II, His Tag on SDS-PAGE under reducing (R) condition. RELATED PRODUCTS: Apolipoprotein AII, Human Plasma (7281) Human CellExp™ ApoA-1, human recombinant (7403) FOR RESEARCH USE ONLY! Not to be used on humans. 155 S. Milpitas Blvd., Milpitas, CA 95035 USA | T: (408)493-1800 F: (408)493-1801 | www.biovision.com | [email protected] .

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The Expression of the Human Apolipoprotein Genes and Their Regulation by Ppars
CORE Metadata, citation and similar papers at core.ac.uk Provided by UEF Electronic Publications The expression of the human apolipoprotein genes and their regulation by PPARs Juuso Uski M.Sc. Thesis Biochemistry Department of Biosciences University of Kuopio June 2008 Abstract The expression of the human apolipoprotein genes and their regulation by PPARs. UNIVERSITY OF KUOPIO, the Faculty of Natural and Environmental Sciences, Curriculum of Biochemistry USKI Juuso Oskari Thesis for Master of Science degree Supervisors Prof. Carsten Carlberg, Ph.D. Merja Heinäniemi, Ph.D. June 2008 Keywords: nuclear receptors; peroxisome proliferator-activated receptor; PPAR response element; apolipoprotein; lipid metabolism; high density lipoprotein; low density lipoprotein. Lipids are any fat-soluble, naturally-occurring molecules and one of their main biological functions is energy storage. Lipoproteins carry hydrophobic lipids in the water and salt-based blood environment for processing and energy supply in liver and other organs. In this study, the genomic area around the apolipoprotein genes was scanned in silico for PPAR response elements (PPREs) using the in vitro data-based computer program. Several new putative REs were found in surroundings of multiple lipoprotein genes. The responsiveness of those apolipoprotein genes to the PPAR ligands GW501516, rosiglitazone and GW7647 in the HepG2, HEK293 and THP-1 cell lines were tested with real-time PCR. The APOA1, APOA2, APOB, APOD, APOE, APOF, APOL1, APOL3, APOL5 and APOL6 genes were found to be regulated by PPARs in direct or secondary manners. Those results provide new insights in the understanding of lipid metabolism and so many lifestyle diseases like atherosclerosis, type 2 diabetes, heart disease and stroke.
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