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Inflammation, Infection and Immunity in Digestive Disease

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Inflammation, Infection and Immunity in Digestive Disease Diamantina Health Partners Inflammation, Infection and Immunity in Digestive Disease Research Workshop 2014 Date: 16th May 2014 Time: 8:00am – 2:00pm Venue: Translational Research Institute Room 2004 Hosted by Department of Gastroenterology and Hepatology PAH Convenors: Professor Gerald Holtmann Program Committee: Assoc Professor Linda Fletcher (Chair) Dr Brad Kendall Professor Mike McGuckin Professor Elizabeth Powell Co-ordinator Ms Mary-Anne Stockwell Introduction Dear colleagues, Digestive disorders are a spectrum of disorders affecting the alimentary canal, liver and biliary system, and pancreas. The impact of these diseases ranges from the inconvenience of a transient diarrheal disease causing missed time from work, to chronic and debilitating illnesses requiring continuous medical care, or, all too frequently, to dreaded conditions such as oesophageal, colonic or pancreatic cancer that are usually fatal. During the 20th century, dramatic changes in the incidence and prevalence of digestive diseases have occurred. For some diseases such as peptic ulcer disease, cures have been found and in the clinic we can now successfully treat these patients. This is testament to the benefits that collaboration of scientists with clinical medicine can deliver. Conversely, there are other – primarily inflammatory or infectious diseases – that have become much more prevalent and represent a considerable and growing burden to patients and society. These conditions include inflammatory bowel disorders, non-alcoholic fatty liver diseases, viral hepatitis and irritable bowel disorders. It is now well accepted that the gastrointestinal tract hosts a distinct array of microorganisms. Emerging evidence also indicates that this microbiome, and its interaction with the host, plays a critical role in many extra-intestinal diseases including rheumatic conditions, diabetes and obesity. Encompassing the overarching aim of promoting better gastrointestinal and liver health through research, the workshop will build on existing expertise and strengths, and strive to develop new approaches and partnerships, in line with the DHP theme of Inflammation, Infection and Immunity, specifically relevant to Digestive and Liver Disease. The workshop will include ‘state of the art’ overviews of current and emerging concepts presented by senior staff, as well as presentations by scientists and junior medical staff presenting their work in progress. The program will include topics such as emerging concepts of systems biology and gastrointestinal disease, the role of infections in IBD, mucosal biology in IBS and paradigm shifts for viral liver disease and non-alcoholic steatohepatitis, along with a mini update on liver cancer. The primary aim of this workshop is to bring together contributors from the Hospitals in Metro South, the TRI, the University of Queensland, the Diamantina Institute, the Mater Research Institute and other relevant stakeholders. The workshop can only provide a glimpse of the research that is happening in the field of digestive disorders; however it can provide a platform for interaction between clinicians who are directly involved in patient care and scientists who are driving the science of medical research. The opportunity to interact and build new relationships will pay dividends through improved collaboration and ultimately better outcomes for patients. Professor Gerald Holtmann, Director, Department of Gastroenterology & Hepatology Princess Alexandra Hospital; Associate Dean Clinical University of Queensland Faculty of Medicine & Biomedical Sciences and Faculty of Health & Behavioural Sciences FRIDAY 16th May 2014 Program 8.00 Registration, Tea and Coffee 8.15 Opening Professor Gerald Holtmann - Director Gastroenterology and Hepatology, Associate Dean Clinical Faculty of Medicine and Biomedical Sciences & Faculty of Health and Behavioural Sciences University of Queensland Dr David Theile AO - Chairman, Diamantina Health Partners Professor Melissa Brown - Deputy Executive Dean and Associate Dean (Research) Faculty of Medicine and Biomedical Sciences, University of Queensland SESSION 1: Chairs:Mark Morrison and Tim Florin THE MICROBIOME & INFLAMMATION: INTESTINAL AND EXTRAINTESTINAL CONSEQUENCES 8.30 MINI STATE OF THE ART: The GI Microbiome - Mark Morrison 8.45 Mucosal permeability, microbiota and liver disease - Ashok Raj 8.55 Ascites and microbiota - Kevin Fagan 9.05 Microbiota diversity in ulcerative colitis - Paraic O’Cuiv 9.15 The microbiome in functional dyspepsia - Erin Shanahan 9.20 Endobarrier in obesity and metabolic diseasel - Graeme Rich 9.30 MINI STATE OF THE ART: Functional MRI - Marcus Gray 9.45 GI inflammation and central processing of afferences - Jeff Chao 10.00 Discussion 10.10 TEA SESSION 2: Chairs: Elizabeth Powell and Carolyn McIvor INFLAMMATION AND LIVER DISEASE 10.30 MINI STATE OF THE ART: Inflammation & The Liver - Elizabeth Powell 10.45 Rapid access model of care in HCV - Marianne Black 10.55 Therapeutic models of DILI - Iulia Onacea 11.05 Inflammatory co-factors in progressive liver injury - Terrence Tan 11.15 Population approaches to liver cancer epidemiology - Paul Clark 11.25 Update on the HCC database - Katherine Stuart 11.35 Fibroscan in viral hepatitis - Peter Hendy 11.45 Muscle mass, hepatic function and outcomes in liver transplantation - Aiden Woodward 11.55 Non-invasive predictors for decompensation in liver disease - James Thomas 12.05 Discussion 12.15 LUNCH FRIDAY 16th May 2014 Program SESSION 3: Chairs: Mike McGuckin and Gerald Holtmann INFLAMMATION AND GI DISEASE 12.45 MINI STATE OF THE ART: Gut Mucosal Inflammation - Mike McGuckin 13.00 Underpinning for a trial for a novel therapy for IBD - Tim Florin 13.10 Autophagy in IBD - Jake Begun 13.20 Novel mechanisms for IL-23-mediated pathology in colitis - Ran Wang 13.30 Muscularis propria resection in Barrett’s oesophagus - Andrew St John 13.40 Enteral nutrition in Crohn’s disease - Natalie Kiel 13.45 Beta-defensins as a novel treatment for IBD - Dan Croker 13.50 Discussion 14.00 CONCLUSION Participants PARTICIPANTS TITLE AFFILIATIONS Abstract No. Prof Gerald Holtmann Director, Gastroenterology Gastroenterology & Hepatology, & Hepatology Princess Alexandra Hospital; Faculty Associate Dean (Clinical) of Medicine and Biomedical Sciences and Faculty of Health and Behavioral Sciences, University of Queensland Dr David Theile AO Chief Executive Officer Diamantina Health Partners Professor Melissa Brown Deputy Executive Dean & Faculty of Medicine and Biomedical Associate Dean (Research) Sciences, University of Queensland Professor Mark Morrison Chair & Group Leader Diamantina Institute, University of 1 Metagenomics Queensland Professor Tim Florin Head, Inflammatory Bowel Mater Research Institute, University 15 Diseases Group of Queensland Dr Ashok Raj PhD Scholar School of Medicine, University of 2 Queensland; Gastroenterology & Hepatology, Princess Alexandra Hospital Dr Kevin Fagan Research Fellow Gastroenterology & Hepatology, 3 Princess Alexandra Hospital; School of Medicine, University of Queensland Dr Paraic O’Cuiv Research Fellow Diamantina Institute, University of 4 Queensland Dr Erin Shanahan Postdoctoral Research Gastroenterology & Hepatology, 5 Fellow Princess Alexandra Hospital Dr Graeme Rich Medical Registrar Gastroenterology & Hepatology, 6 Princess Alexandra Hospital Dr Marcus Gray Postdoctoral Research University of Queensland Centre for Fellow Advanced Imaging Dr Jeff Chao Gastroenterology and Gastroenterology & Hepatology, 7 Hepatology Fellow Princess Alexandra Hospital Professor Elizabeth Powell Hepatologist and NHMRC Gastroenterology & Hepatology, Practitioner Fellow Princess Alexandra Hospital; School of Medicine, University of Queensland Dr Carolyn McIvor Director Gastroenterology & Gastroenterology, Logan Hospital Hepatology, Logan Hospital PARTICIPANTS TITLE AFFILIATIONS Abstract No. Ms Marianne Black Clinical Nurse Gastroenterology and Hepatology, 8 Princess Alexandra Hospital Dr Iulia Onacea Research Officer, Mater Research Institute, University 9 Inflammatory Bowel of Queensland Diseases Group Dr Terrence Tan Gastroenterologist & Gastroenterology & Hepatology, 10 Hepatologist Princess Alexandra Hospital Dr Paul Clark Postdoctoral Fellow & Gastroenterology & Hepatology, 11 Gastroenterologist Princess Alexandra Hospital; Cancer Control Unit, Berghoffer – QIMR Dr Katherine Stuart Director of Hepatology Gastroenterology & Hepatology, Princess Alexandra Hospital Dr Peter Hendy Advanced Trainee Gastroenterology & Hepatology, 12 Princess Alexandra Hospital Dr Aiden Woodward Medical Registrar Gastroenterology & Hepatology, 13 Princess Alexandra Hospital Dr James Thomas Hepatology Fellow Gastroenterology & Hepatology, 14 Princess Alexandra Hospital Professor Michael NHMRC Principal Research Mater Research Institute, University McGuckin Fellow; Deputy Director of Queensland (Research) Dr Jake Begun Gastroenterologist and Mater Research Institute, University 16 Research Fellow of Queensland Ms Ran Wang PhD Scholar Mater Research Institute, University 17 of Queensland Dr Andrew St John Gastroenterologist Gastroenterology & Hepatology, 18 Princess Alexandra Hospital Dr Natalie Kiel Gastroenterology Fellow Gastroenterology & Hepatology, 19 Princess Alexandra Hospital Dr Daniel Croker Postdoctoral Researcher Institute for Molecular Bioscience, 20 University of Queensland Assoc Professor Linda Senior Scientist Gastroenterology & Hepatology, Fletcher Princess Alexandra Hospital; School of Medicine, University of Queensland Dr Brad Kendall Gastroenterologist
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