Molecular Probes Inc. Monsanto
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BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information Molecular Probes Inc. P.O. Box 22010, 29851 Willow Creek Road Eugene OR 97402-0469, US Phone: (541) 465-8300; Fax: (541) 335-0504 Toll-free phone: (800) 438-2209 (orders only) Web: www.probes.invitrogen.com E-mail: tech@probes.com KEY PERSONNEL: August Sick; General Manager EMPLOYEES: 160 employees HISTORY: Founded in 1975 Acquired by Invitrogen Corp. (8/03) STOCK-FINANCIAL HISTORY: Privately held SUBSIDIARIES/DIVISIONS: Molecular Probes Europe BV--wholly owned subsidiary located in the Netherlands SUBSIDIARY OF: Invitrogen Corp. (see separate entry) BUSINESS STRATEGY: Be the leading provider of fluorescence-based detection solutions to advance scientific and biomedical research PRODUCTS ON MARKET: Over 3,000 fluorescent probes for bioscience research listed in the 'Handbook of Fluorescent Probes and Research Chemicals' including Calcium Green™, Live/Dead® viability/cytotoxicity kits, SYBR® Green nucleic acid gel stain, SYPRO® Protein gel stain, FluoSpheres®, Cascade Blue®, Toto®-1, Yoyo®-1 and Bodipy® Monsanto Co. 800 North Lindbergh Boulevard St. Louis MO 63167, US Phone: (314) 694-1000; Fax: (314) 694-4228 Web: www.monsanto.com E-mail: info@monsanto.com KEY PERSONNEL: Hugh Grant; Chairman, President and CEO Terrell K. Crews; Exec. VP and CFO Dr. Robert T. Fraley; Exec. VP and CTO Charles W. Burson; Exec. VP, Secretary and General Counsel Carl M. Casale; Exec. VP, North America Commercial Brett D. Begemann; Exec. VP, International Commercial Robert A. Paley; VP and Treasurer Mark J. Leidy; Exec. VP, Manufacturing Gerald A. Steiner; Exec. VP, Commercial Acceptance Steven C. Mizell; Sr. VP, Human Resources Cheryl Morley; Sr. VP, Corporate Strategy Richard B. Clark; VP and Controller Janet M. Holloway; VP and Chief of Staff Scarlett Lee Foster; VP, Investor Relations EMPLOYEES: 22,000 employees HISTORY: Founded in 1901 Agricultural division established (1960) Began biotech R&D in 1979 Acquired the Jacob Hartz Seed Co. (1982) Acquired 49% of Calgene Inc. (3/96) Acquired Agracetus (7/96) Increased ownership of Calgene Inc. to 54.6% through purchase of 6.25M shares (8/96) Copyright ©2006 AHC Media® 247 BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information Acquired Asgrow agronomics seed business (1997) Acquired Holden's Foundation Seeds Inc., Corn States Hybrid Service Inc. and Corn States International Sarl for up to $1b (1/97) Acquired remaining shares of Calgene for $8/share, $240M (7/97) Monsanto split into two companies--Monsanto Co. (life sciences, agriculture, health and food products) and Solutia Inc. (chemicals and fibers) (9/97) Announced plans to acquire remaining shares of Dekalb Genetics Corp. for $2.5b and Delta & Pine Land Co. for an undisclosed amount (5/98) American Home Products Corp. (now Wyeth) and Monsanto Co. announced plans to merge for $33b in stock and to create new company (6/98) Announced plans to acquire Cargill's international seed operations in Central and Latin America, Europe, Asia and Africa for $1.4b (6/98) Merged with Pharmacia & Upjohn to form Pharmacia Corp. Monsanto is the acknowledged agricultural subsidiary and will retain its name, while Pharmacia owns 85% of Monsanto. The business became a separate legal entity with a stand-alone board of directors and its own publicly traded stock. (4/00) Divested by Pharmacia Corp. in lieu of Pharmacia's merger into Pfizer Inc. (4/03) Formed American Seeds Inc. (ASI) (2004) ASI acquired Channel Bio Corp. (including three seed brands: Crows Hybrid Corn, Midwest Seed Genetics and Wilson Seeds) (2004) Acquired North American canola seed assets of Advanta Seeds from Advanta BV (9/04) Acquired the Stoneville cotton business (including its NexGen brand) (2005) ASI subsidiary acquired NC+ Hybrids Inc. (2005) ASI acquired Fontanelle Hybrids, Stewart Seeds, Trelay Seeds and Stone Seeds (2005) ASI acquired Specialty Hybrids (2005) Acquired agricultural genomics assets of Icoria Inc. (3/05) Acquired Seminis Inc. (3/05) Acquired Emergent Genetics Inc. (4/05) Sold Monsanto Enviro-Chem Systems Inc. (8/05) ASI acquired the seed marketing and sales businesses of Diener Seeds and and Sieben Hybrids (6/06) ASI to acquire Kruger Seed Co. Trisler Seed Farms and the seed marketing and sales business of Campbell Seed (as of 6/06) To acquire Delta and Pine Land Co. for $1.5b (as of 8/06) Member--Biotechnology Industry Organization FACILITIES: Manufacturing facilities, laboratories, seed production and other agricultural facilities, office space, warehouses and other land parcels in North America, South America, Europe, Asia, Australia and Africa Seed conditioning plants at Bellary, India; Constantine, Mich.; Eluru, India; Grinnell, Iowa; Kearney, Neb.; Oxnard, Calif.; Peyehorade, France; Phitsanoluk, Thailand; Trebes, France; Uberlandia, Brazil; and Villagran, Mexico Chemicals manufacturing facilities at Alvin, Texas; Antwerp, Belgium; Augusta, Ga.; Camacari, Brazil; Luling, La.; Muscatine, Iowa; Sao Jose dos Campos, Brazil; Soda Springs, Idaho; and Zarate, Argentina STOCK-FINANCIAL HISTORY: NYSE--MON Net sales $6.294b (YE 05) compared to $5.423b (YE 04) Net income $255M (YE 05) compared to $267M (YE 04) Earnings per share $0.94/share (YE 05) compared to $0.99/share (YE 04) Average shares outstanding 266.8M (YE 05) compared to 264.4M (YE 04) SUBSIDIARIES/DIVISIONS: Two business segments: Seeds and Genomics (global seeds and traits businesses and genetic technology platforms) Agricultural Productivity (crop protection products, animal agriculture businesses and lawn-and-garden herbicide products) INVESTMENTS: The Liposome Co. Target Therapeutics HybriTech Seed Europe-SNC--joint venture with CACBA Calgene Inc.--100% Copyright ©2006 AHC Media® 248 BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information Joint venture with Cargill to use biotechnology to improve feed for pigs, cattle, poultry and fish (5/98) Formed American Seeds Inc. (ASI), a holding company to support regional seed businesses (11/04) BUSINESS STRATEGY: Produce leading seed brands and develop biotechnology traits that assist farmers in controlling insects and weeds Provide other seed companies with genetic material and biotechnology traits for their seed brands Provide lawn-and-garden herbicide products for the residential market Provide animal agricultural products focused on improving dairy cow productivity and swine genetics AGREEMENTS: Name Products Content of Agreement Date Genaissance to map single nucleotide research agreement 3/05 Pharmaceuticals polymorphism (SNP) Inc. and the DNA markers in Agricultural soybeans Research Service (part of USDA) Agracetus Inc. transgenic cotton purchased all plant 4/96 technology biotech assets from W.R. Grace & Co Arcadia development and licensing agreement 9/05 Biosciences Inc. commercialization of Arcadia's nitrogen use efficiency technology in canola ArQule Inc. agrochemicals development 12/96 agreement Calgene Inc. fresh produce and plant R&D agreement 10/95 oils Calgene Inc. oilseed research cross-licensing 5/96 programs agreement-- Calgene will receive royalty-free license to current and future Monsanto agronomic technology in combination with Calgene's oils modification genes. Monsanto will pay Calgene royalties and $17M and will receive portion of profits of Calgene's specialty oils business Calgene Inc. patented technologies cross-licensing 4/93 agreements-- Monsanto received licenses to Calgene's patents and patents pending in the areas of plant transformation, certain genetically engineered plants, and antisense RNA technology. Calgene received licenses to Copyright ©2006 AHC Media® 249 BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information Monsanto's patents and patents pending in the areas of plant transformation technologies, selectable markers, and the right to obtain certain licenses to Monsanto's Bt insect resistance technology for use in cotton Calgene Inc. Russet Burbank development potatoes genetically agreement modified to resist potato viruses X and Y California Institute instrument design development of Technology agreement Columbia patented rDNA nonexclusive University extraction process licensing agreement Dekalb Genetics field crops, seeds, R&D collaboration 2/96 Corp. produce and cross-licensing agreement Delta and Pine Bollard gene for marketing 11/95 Land Co. selected varieties of agreement cotton Divergence Inc. nematode-resistant development and 9/04 soybeans licensing agreement Dow new technology options global business 1/06 AgroSciences LLC and more choice in agreement products for farmers Dyax Corp. Dyax's phage display non-exclusive 5/97 technology licensing agreement, including signing fees, milestone payments and royalties, Dyax gets access to related patented technology owned by licensee Ecogen Inc. Bt technology for in- development 1/96 plant applications agreement Finnfeeds feed microingredients joint venture for for 4/98 production and marketing of feed microingredients in plants GeneTrace Inc. plant and animal $17M technology 4/98 genomics collaboration-- Monsanto gets exclusive license to GeneTrace's technology for plant and animal genomics, including gene-expression analysis and genotyping Copyright ©2006 AHC Media® 250 BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information Incyte Incyte's gene 3-year, large-scale, 5/98 Pharmaceuticals expression microarray genome-wide