Respiratory Syncytial Virus

RSV Respiratory syncytial virus

RSV (Respiratory syncytial virus) is a virus that causes respiratory tract infections. RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, which includes common respiratory viruses such as those causingmeasles and mumps. RSV is a member of the paramyxovirus subfamily Pneumovirinae. RSV is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood.

www.MedChemExpress.com 1 RSV Inhibitors & Modulators

Ac-CoA Synthase Inhibitor1 ALS-8112 Cat. No.: HY-104032 Cat. No.: HY-12983

Bioactivity: Ac-CoA Synthase Inhibitor1 is an anti-virus agent. Bioactivity: ALS-8112 is a potent and selective respiratory syncytial virus ( RSV) polymerase inhibitor. The 5'-triphosphate form of

ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

Purity: 99.03% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Lumicitabine PC786 (ALS-008176; ALS-8176) Cat. No.: HY-12983A Cat. No.: HY-102038

Bioactivity: Lumicitabine (ALS-008176) is an inhibitor of the respiratory Bioactivity: PC786 is an inhaled respiratory syncytial virus ( RSV) L syncytial virus ( RSV) polymerase. protein polymerase inhibitor. PC786 demonstrates potent

antiviral activity against RSV-A ( IC50 <0.09 to 0.71 nM) [1] and RSV-B ( IC50, 1.3 to 50.6 nM) . Purity: 99.78% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Presatovir RD3-0028 (GS-5806) Cat. No.: HY-16727 Cat. No.: HY-100285

Bioactivity: Presatovir (GS-5806) is a novel, orally bioavailable RSV Bioactivity: RD3-0028 is a potent and selective inhibitor of RSV

fusion inhibitor with a mean EC50 value of 0.43 nM. replication with an EC50 of 4.5 μM.

Purity: 99.95% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

Ribavirin RSV-IN-1 (ICN-1229) Cat. No.: HY-B0434 Cat. No.: HY-112673

Bioactivity: Ribavirin (ICN-1229) is an antiviral agent against a broad Bioactivity: RSV-IN-1 is a human respiratory syncytical virus (hRSV)

spectrum of viruses including HCV, HIVl, and RSV. inhibitor, with an IC50 of 0.11 μM.

Purity: 98.0% Purity: 99.83% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg 5 mg, 10 mg

RSV604 RSV604 R enantiomer Cat. No.: HY-12993 Cat. No.: HY-12993B

Bioactivity: RSV604 is a novel inhibitor of respiratory syncytial virus Bioactivity: RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) an inhibitor of respiratory syncytial virus (RSV) replication. inhibitor in phase 2 clinical trials. IC50 value: 0.86 R-enantiomer is less active against RSV. uM(EC50) [1] Target: RSV inhibitor RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved… Purity: 99.88% Purity: 77.97% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

RSV604 racemate TMC353121 Cat. No.: HY-12993A Cat. No.: HY-11097

Bioactivity: RSV604 racemate is a racemic mixture, shows less potency Bioactivity: TMC353121 is a potent respiratory syncytial virus ( RSV) against strains of respiratory syncytial virus (RSV) than the fusion inhibitor with pEC50 of 9.9. S-isomer.

Purity: 98.37% Purity: 97.71% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg