Bard1 (NM 022622) Rat Tagged ORF Clone Lentiviral Particle Product Data

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for RR203817L4V

Bard1 (NM_022622) Rat Tagged ORF Clone Lentiviral Particle Product data:

Product Type: Lentiviral Particles Product Name: Bard1 (NM_022622) Rat Tagged ORF Clone Lentiviral Particle Symbol: Bard1 Vector: pLenti-C-mGFP-P2A-Puro (PS100093) ACCN: NM_022622 ORF Size: 2304 bp ORF Nucleotide The ORF insert of this clone is exactly the same as(RR203817). Sequence: OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. RefSeq: NM_022622.1, NP_072144.1 RefSeq Size: 2499 bp RefSeq ORF: 2307 bp Locus ID: 64557 UniProt ID: Q9QZH2 Gene Summary: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.[UniProtKB/Swiss-Prot Function]