Common Ground How Bipartisanship Produced the Largest Land Conservation Legislation in a Decade
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Music That Inspires! JAN. 2018 Live Music Schedule
CUP O JOY – Music That Inspires! 232 S. Broadway St. Green Bay, WI 54303 920-435-3269 www.cupojoy.com JAN. 2018 Live Music Schedule (Changes to printed schedule will be updated at www.cupojoy.com) FRI JAN 5 MECAN RIVER RAMBLERS - a Wisconsin based bluegrass band bringing contemporary and traditional bluegrass and acoustic music. Show 7:30pm, SAT JAN 6 SWING’N ANGELS big band - Stand up, clap your hands, to this lively 16+ piece BIG BAND which includes a full HORN section.7:30pm, Doors 6:45pm! FRI JAN 12 REDSTAR EXPRESS – brings you traditional BLUEGRASS music along with a good many other old-time favorites in its Opry-style shows. 7:30pm Show! SAT JAN 13 FAMILY NIGHT – with Monty from Monty's Magic Theater– An EarlyNight of Fun so bring the kids out. Monty holds 3 Guinness World Records for slight of hand tricks, bringing wonder and audience participation to everyone's delight! Show 7pm (doors open 6:30). FRI JAN 19 OPEN MIC–take the stage. Show 7pm, doors open at 6:30pm SAT JAN 20 SHAWN MCDONALD – The single, We Are Brave', went #1 on CHR. Shawn entered the music scene in 2004 with Simply Nothing and has offered up so many great and thoughtful hits. Now with a New CD and One Show Only! With Guest: TBA 7:30pm, Doors 6:45pm 4 Shows – A Weekend of Comedy with: FRI JAN 27 JEFF ALLEN– The World’s Funniest, totally clean Comedian for adults. Jeff Allen combines clean, hilarious humor with inspiration like no other comedian working today. -
USA Education Ph.D., Biology, Massachusetts Institute of Tech
Victor R. Ambros, Ph.D. Silverman Professor of Natural Sciences Program in Molecular Medicine University of Massachusetts Medical School373 Plantation Street, Suite 306 Worcester, MA 01605 (508) 856-6380 [email protected] Personal Born: Hanover, NH, USA on December 1, 1953 Citizenship: USA Education Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA 1976-1979 Thesis Title: The protein covalently linked to the 5' end of poliovirus RNA Advisor: Dr. David Baltimore B.S., Biology, Massachusetts Institute of Technology, Cambridge, MA 1971-1975 Professional Appointments Silverman Professor of Natural Sciences 2009-present Co-Director, RNA Therapeutics Institute 2009-2016 Professor, Program in Molecular Medicine 2008-present University of Massachusetts Medical School, Worcester, MA Professor of Genetics, Dartmouth Medical School 2001-2007 Professor, Biological Sciences, Dartmouth Medical School 1996-2001 Associate Professor, Biological Sciences, Dartmouth Medical School 1992-1996 Associate Professor, Department of Cellular and Development Biology, 1988-1992 Harvard University, Cambridge, MA Assistant Professor, Department of Cellular and Development Biology, 1985-1988 Harvard University, Cambridge, MA Postdoctoral Research 1979-1985 Supervisor: Dr. H. Robert Horvitz Massachusetts Institute of Technology, Cambridge, MA Graduate Research 1976-1979 Supervisor: Dr. David Baltimore Massachusetts Institute of Technology, Cambridge, MA Research Assistant 1975-1976 Supervisor: Dr. David Baltimore Center for Cancer Research, -
Nature Medicine Essay
COMMENTARY LASKER BASIC MEDICAL RESEARCH AWARD Of maize and men, or peas and people: case histories to justify plants and other model systems David Baulcombe One of the byproducts of molecular biology cork is altogether filled with air, and that air is has been support for the ‘model system’ con- perfectly enclosed in little boxes or cells distinct cept. All living organisms are based on the same from one another.”)2 (Fig. 1). Two hundred fifty genetic code, they have similar subcellular years later, Beijerinck discovered a contagium structures and they use homologous metabolic vivum fluidum in extracts of diseased tobacco pathways. So, mechanisms can be investigated plants that he later referred to as a virus3. using organisms other than those in which In contemporary science, a green alga— the knowledge will be exploited for practical Chlamydomonas reinhardtii—is a useful model benefit. Model systems are particularly use- in the analysis of kidney disease4. However, ful in the early discovery phase of a scientific in this article, I refer to the contribution of endeavor, and recent progress in biomedical plant biology to a family of mechanisms that I science has fully vindicated their use. Jacques refer to as RNA silencing. This topic has been Monod, for example, famously justified his reviewed comprehensively elsewhere5,6, so here work on a bacterial model system by stating I focus on personal experience and my view of that “what is true for Escherichia coli is also future potential from this work. true for elephants.” My fellow laureates, Victor Ambros and Gary Ruvkun, can defend the use The early history of RNA silencing in of the worm Caenorhabditis elegans as a good plants model system and so I will focus on plants. -
Ethical Principles in Ethical Principles in Scientific Research Scientific Research and Publications
Hacettepe University Institute of Oncology Library ETHICAL PRINCIPLES IN SCIENTIFIC LectureRESEARCH author AND PUBLICATIONSOnlineby © Emin Kansu,M.D.,FACP ESCMID ekansu@ada. net. tr Library Lecture author Onlineby © ESCMID HACETTEPE UNIVERSITY MEDICAL CENTER Library Lecture author Onlineby © ESCMID INSTITUTE OF ONCOLOGY - HACETTEPE UNIVERSITY Ankara PRESENTATION • UNIVERSITY and RESEARCHLibrary • ETHICS – DEFINITION • RESEARCH ETHICS • PUBLICATIONLecture ETHICS • SCIENTIFIC MISCONDUCTauthor • SCIENTIFIC FRAUD AND TYPES Onlineby • HOW TO PREVENT© UNETHICAL ISSUES • WHAT TO DO FOR SCIENTIFIC ESCMIDMISCONDUCTS Library Lecture author Onlineby © ESCMID IMPACT OF TURKISH SCIENTISTS 85 % University – Based 1.78% 0.2 % 19. 300 18th ‘ACADEMIA’ UNIVERSITY Library AN INSTITUTION PRODUCING and DISSEMINATING SCIENCE Lecture BASIC FUNCTIONS author Online-- EDUCATIONby © -- RESEARCH ESCMID - SERVICESERVICE UNIVERSITY Library • HAS TO BE OBJECTIVE • HAS TO BE HONESTLecture AND ETHICAL • HAS TO PERFORM THEauthor “STATE-OF-THE ART” • HAS TO PLAYOnline THEby “ROLE MODEL” , TO BE GENUINE AND ©DISCOVER THE “NEW” • HAS TO COMMUNICATE FREELY AND HONESTLY WITH ALL THE PARTIES INVOLVED IN ESCMIDPUBLIC WHY WE DO RESEARCH ? Library PRIMARY AIM - ORIGINAL CONTRIBUTIONS TO SCIENCE Lecture SECONDARY AIM author - TOOnline PRODUCEby A PAPER - ACADEMIC© PROMOTION - TO OBTAIN AN OUTSIDE SUPPORT ESCMID SCIENTIFIC RESEARCH Library A Practice aimed to contribute to knowledge or theoryLecture , performed in disciplined methodologyauthor and Onlineby systematic approach© -
PIE-1 Sumoylation Promotes Germline Fates and Pirna-Dependent Silencing in C
RESEARCH ARTICLE PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans Heesun Kim1†, Yue-He Ding1†, Shan Lu2, Mei-Qing Zuo2, Wendy Tan1, Darryl Conte Jr1, Meng-Qiu Dong2, Craig C Mello1,3* 1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States; 2National Institute of Biological Sciences, Beijing, China; 3Howard Hughes Medical Institute, Chevy Chase, United States Abstract Germlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or maintain the germline fate. In early Caenorhabditis elegans embryos, the CCCH zinc finger protein PIE-1 localizes to the germline where it prevents somatic differentiation programs. Here, we show that PIE-1 also functions in the meiotic ovary where it becomes SUMOylated and engages the small ubiquitin-like modifier (SUMO)-conjugating machinery. Using whole-SUMO-proteome mass spectrometry, we identify HDAC SUMOylation as a target of PIE-1. Our analyses of genetic interactions between pie-1 and SUMO pathway mutants suggest that PIE-1 engages the SUMO machinery both to preserve the germline fate in the embryo and to promote Argonaute-mediated surveillance in the adult germline. *For correspondence: Introduction [email protected] During every life cycle, the eukaryotic germline orchestrates a remarkable set of informational tasks †These authors contributed that shape heredity and create variation necessary for the evolution of new species. One approach equally to this work for understanding the mechanisms that promote germline specification and function has been the identification of genes whose protein products localize exclusively to the germline and for which Competing interests: The loss-of-function mutations result in absent or non-functional germ cells and gametes (Seydoux and authors declare that no Braun, 2006). -
Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA
GENE SILENCING BY DOUBLE STRANDED RNA Nobel Lecture, December 8, 2006 by Andrew Z. Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA. I would like to thank the Nobel Assembly of the Karolinska Institutet for the opportunity to describe some recent work on RNA-triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we’ll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer... the best we could do as of December 8th, 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I’m pleased and proud that work from my labo- ratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. DOUBLE STRANDED RNA AS A BIOLOGICAL ALARM SIGNAL These disclaimers in hand, the story can now start with a biography of the first main character. Double stranded RNA is probably as old (or almost as old) as life on earth. -
2006 Nobel Laureates Hearing Committee On
S. HRG. 110–1209 2006 NOBEL LAUREATES HEARING BEFORE THE SUBCOMMITTEE ON SCIENCE, TECHNOLOGY, AND INNOVATION OF THE COMMITTEE ON COMMERCE, SCIENCE, AND TRANSPORTATION UNITED STATES SENATE ONE HUNDRED TENTH CONGRESS FIRST SESSION MAY 2, 2007 Printed for the use of the Committee on Commerce, Science, and Transportation ( U.S. GOVERNMENT PRINTING OFFICE 79–907 PDF WASHINGTON : 2013 For sale by the Superintendent of Documents, U.S. Government Printing Office Internet: bookstore.gpo.gov Phone: toll free (866) 512–1800; DC area (202) 512–1800 Fax: (202) 512–2104 Mail: Stop IDCC, Washington, DC 20402–0001 VerDate Nov 24 2008 09:23 Mar 19, 2013 Jkt 075679 PO 00000 Frm 00001 Fmt 5011 Sfmt 5011 S:\GPO\DOCS\79907.TXT JACKIE SENATE COMMITTEE ON COMMERCE, SCIENCE, AND TRANSPORTATION ONE HUNDRED TENTH CONGRESS FIRST SESSION DANIEL K. INOUYE, Hawaii, Chairman JOHN D. ROCKEFELLER IV, West Virginia TED STEVENS, Alaska, Vice Chairman JOHN F. KERRY, Massachusetts JOHN MCCAIN, Arizona BYRON L. DORGAN, North Dakota TRENT LOTT, Mississippi BARBARA BOXER, California KAY BAILEY HUTCHISON, Texas BILL NELSON, Florida OLYMPIA J. SNOWE, Maine MARIA CANTWELL, Washington GORDON H. SMITH, Oregon FRANK R. LAUTENBERG, New Jersey JOHN ENSIGN, Nevada MARK PRYOR, Arkansas JOHN E. SUNUNU, New Hampshire THOMAS R. CARPER, Delaware JIM DEMINT, South Carolina CLAIRE MCCASKILL, Missouri DAVID VITTER, Louisiana AMY KLOBUCHAR, Minnesota JOHN THUNE, South Dakota MARGARET L. CUMMISKY, Democratic Staff Director and Chief Counsel LILA HARPER HELMS, Democratic Deputy Staff Director and Policy Director CHRISTINE D. KURTH, Republican Staff Director and General Counsel KENNETH R. NAHIGIAN, Republican Deputy Staff Director and Chief Counsel SUBCOMMITTEE ON SCIENCE, TECHNOLOGY, AND INNOVATION JOHN F. -
Advanced Information on the Nobel Prize in Physiology Or Medicine 2006
Advanced Information on The Nobel Prize in Physiology or Medicine 2006 RNA INTERFERENCE This year’s Nobel Prize in Physiology or Medicine is shared by Professor Andrew Z. Fire at Stanford University, California, USA, and Professor Craig C. Mello at the University of Massachusetts Medical School in Worcester, USA. They receive the prize for their discovery that double-stranded RNA trig- gers suppression of gene activity in a homology-dependent manner, a process named RNA interference (RNAi). Their discovery revealed a new mechanism for gene regulation, and the biochemical machinery involved plays a key role in many essential cellular processes. Double-stranded RNA synthesized within the cell can reduce or abolish gene activity by RNAi-like mechanisms. This control system for gene expression has proven to be important for both the development of an organism and the physiological functions of cells and tissues. Furthermore, RNAi protects against RNA virus infections, especially in plants and invertebrate animals, and secures genome stability by keeping mobile elements silent. Today, double-stranded RNA is used as a powerful tool to experimentally elucidate the function of essentially any gene in a cell. The discovery of RNAi has already had an immense impact on biomedical research and will most likely lead to novel medical applications in the future. Introduction The gene expression process is of fundamental importance for all living organisms. Most genes reside in the chromosomes located in the cell nucleus and express themselves via proteins synthesised in the cytoplasm. The genetic material was identifi ed as deoxyribonucleic acid (DNA) in 1944 (ref. 1) and the double-helical nature of DNA was revealed in 1953 (by Francis Crick, James Watson and Maurice Wilkins; Nobel Prize in Physiology or Medicine in 1962). -
ILAE Historical Wall02.Indd 10 6/12/09 12:04:44 PM
2000–2009 2001 2002 2003 2005 2006 2007 2008 Tim Hunt Robert Horvitz Sir Peter Mansfi eld Barry Marshall Craig Mello Oliver Smithies Luc Montagnier 2000 2000 2001 2002 2004 2005 2007 2008 Arvid Carlsson Eric Kandel Sir Paul Nurse John Sulston Richard Axel Robin Warren Mario Capecchi Harald zur Hauser Nobel Prizes 2000000 2001001 2002002 2003003 200404 2006006 2007007 2008008 Paul Greengard Leland Hartwell Sydney Brenner Paul Lauterbur Linda Buck Andrew Fire Sir Martin Evans Françoise Barré-Sinoussi in Medicine and Physiology 2000 1st Congress of the Latin American Region – in Santiago 2005 ILAE archives moved to Zurich to become publicly available 2000 Zonismide licensed for epilepsy in the US and indexed 2001 Epilepsia changes publishers – to Blackwell 2005 26th International Epilepsy Congress – 2001 Epilepsia introduces on–line submission and reviewing in Paris with 5060 delegates 2001 24th International Epilepsy Congress – in Buenos Aires 2005 Bangladesh, China, Costa Rica, Cyprus, Kazakhstan, Nicaragua, Pakistan, 2001 Launch of phase 2 of the Global Campaign Against Epilepsy Singapore and the United Arab Emirates join the ILAE in Geneva 2005 Epilepsy Atlas published under the auspices of the Global 2001 Albania, Armenia, Arzerbaijan, Estonia, Honduras, Jamaica, Campaign Against Epilepsy Kyrgyzstan, Iraq, Lebanon, Malta, Malaysia, Nepal , Paraguay, Philippines, Qatar, Senegal, Syria, South Korea and Zimbabwe 2006 1st regional vice–president is elected – from the Asian and join the ILAE, making a total of 81 chapters Oceanian Region -
Spring/Summer 2005, Vol. 27 No. 3 the Magazine of the University Of
Elected to National Academy of Sciences, p. 3 UMMS Professor Craig Mello spring/summer 2005, vol. 27 no. 3 Justice Served The Magazine of The University of Massachusetts Medical School The RNAi Revolution is Here. The Pivotal Pancreas Neural Pioneers Plus, the Economics of RNAi L., the plural of life The name of this magazine encompasses the lives of those who make up the UMMS community, for which it is published. They are students, faculty, staff, alumni, volunteers, benefactors and others who aspire to help this campus achieve national distinction in education, research and public service. University of Massachusetts Medical School The University of Massachusetts Medical School was created in 1962 by an act of the Massachusetts Legislature and today is comprised of three schools. Since accepting its first class in 1970, the School of Medicine has provided students with an accessible, comprehensive and personally rewarding medical education of the highest quality, one which optimally prepares them to excel as physicians. The Graduate School of Biomedical Sciences, opened in 1979, is a faculty-initiated PhD program that trains scientists in a specialty area with a broad background in the basic medical sciences, in preparation for conducting research with direct relevance to human disease. Opened in 1986, the Graduate School of Nursing, through its master’s, post master’s, doctoral degree and Graduate Entry Pathway programs, provides professional educa- tion and training for advanced practice nurses within three specialties: adult acute/critical care nurse practitioners, adult ambulatory/community care nurse practitioners and advanced practice nurse educators. Commonwealth Medicine Commonwealth Medicine is UMass Medical School’s innovative public service initiative, provid- ing expertise to public sector agencies so they may optimize their efficiency and effectiveness. -
Craig C. Mello (1960- ) [1]
Published on The Embryo Project Encyclopedia (https://embryo.asu.edu) Craig C. Mello (1960- ) [1] By: May, Catherine Keywords: Biography [2] DNA and RNA [3] Craig C. Mello is an American developmental biologist and Nobel Laureate, who helped discover RNA interference [4] (RNAi). Along with his colleague Andrew Fire [5], he developed gene knockouts using RNAi. In 2006 Mello won theN obel Prize in Physiology or Medicine [6] for his contribution to the discovery of RNAi. Mello also contributed to developmental biology, focusing on gene regulation [7], cell signaling, cleavage formation, germline determination [8], cell migration [9], cell fate differentiation [10], and morphogenesis. Mello was born in New Haven, Connecticut on 18 October 1960 to Sally Cameron and James Mello. During Mello’s childhood, the family relocated from Connecticut to Falls Church Virginia and then to Fairfax, Virginia, where Mello’s father became assistant director of the Smithsonian Museum of Natural History in Washington, DC. Mello recalled memories of the outdoors, camping, searching for fossils, watching wildlife, and hiking the Blue Ridge Mountains. Mello formed an affinity for science, later stating that science is the best way to approach the world because it asks questions and admits no absolutes. Mello attended Fairfax High School. In 1978 Mello attended Brown University [11] and in 1982 graduated with an undergraduate degree in biochemistry. For graduate school, Mello first attended University of Colorado [12] at Boulder where he studied the nematode worm C. elegans in David Hirsh’s lab and met Mike Krause [13], Jim Kramer [14], Ken Kemphues [15] and Jim Priess [16], who all collaborated with Mello. -
Music That Inspires! Feb. 2017 Live Music Schedule
CUP O JOY – Music That Inspires! 232 S. Broadway St. Green Bay, WI 54303 920 - 435 - 3269 www.cupojoy.com Feb . 201 7 Live Music Schedule ( Changes to printed schedule will be updated at www.cupojoy.com ) FRI FEB 3 JESSICA MARTINDALE – a Nashville singer - songwriter with a n aching wisdom in her voice. BOBBY COVERSTON an infectious gritty, Americana style. Show 7:30pm , Doors 6:45pm SAT FEB 4 RYAN STEVENSON – blends influences from soul, pop, and some of the great guitarists to create engaging acoustic guitar driven melodies such as with his chart - topping song "Eye of the Storm." 7:30pm show, doors 6:45pm. FRI FEB 10 GRASSCUTTERS - Three piece bluegrass WI group that bring s great m usic with guitar , banjo , killer mandolin and the upright bass 7:30pm, Doors at 6:45pm SAT FEB 11 JIM COLE – subtly - textured songs and finger - style guitar playing evoke an outpouring of emotions as Jim touches our hearts with his music. The music is acoustic, warm, and captivating. It is pure and simple, but very poignant. Tonight Jim Cole brings Celebrates Vale ntine's Day to YOU! Show 7:30pm , doors 6:45 FRI FEB 17 OPEN MIC – Come take the stage. Show 7pm , doors open at 6:30pm SAT FEB 18 SHAWN MCDONALD – The single, We Are Brave', went #1 on CHR. Shawn entered the music scene in 2004 with Simply Nothing and has offered up so many great and thoughtful hits. One S how Only! With Guest: ASH BULTMAN 7:30pm, Doors 6:45pm FRI FEB 24 JOSHUA CARSWELL – performed at the 2016 Cup Benefit Concert w / the Annie Moses Band.