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Home , Globe (human eye), Optic cup (anatomical)

Neuroanatomy Suzanne Stensaas February 24, 2011, 10:00-12:00 p.m.

Reading: Waxman Ch. 15. Your histology and gross anatomy books should be useful. Reading: Histology of the from any histology book you have as well as gross anatomy text Much of this you will have to learn on your own and hope that physiology will add some more detail.

THE EYE: AND

Objectives: 1. Describe the production, circulation and removal of aqueous humor. 2. Name the neural elements that compose the retina, and their location and function within the retina. 3. Explain for what purpose the macula/fovea exists. 4. Ophthalmologists use the term choked or raised disc and depressed or cupped disc. Explain the pathophysiology that leads to these states. 5. Describe the medical significance of a careful examination of the optic nerve. Why is it a window on the brain?

I. EMBRYOLOGY A. Two evaginations, the optic vesicles, develop from prosencephalon. 1. Come to be associated with diencephalon.

2. results from invagination of optic vesicle. a. Outer layer, retinal pigment epithelium. b. Inner layer, neural retina. c. Axons from inner layer of optic cup form the optic nerve and grow into the thalamus

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Young, Young, and Tolbert Fig. 14-1

II. FIBROUS (PROTECTIVE) LAYER A. – major refraction of light entering the eye 1. Layers (epithelium, stroma, endothelium) are separated by anterior and posterior limiting membranes. 2. Lamellar orientation of collagen in stroma. 3. Transparency - avascular, very acellular, dependent on active pumping of fluid by endothelial layer. 4. Innervation - ophthalmic branch of V. 5. "Nourished" by aqueous humor and tears.

B. - dense connective tissue, reduced vascular demands, elasticity, innervation by V.

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III. NUTRITIVE LAYER () PIGMENTED AND VASCULAR A. 1. Very vascular capillary plexus - choriocapillaris. 2. Vascular supply to pigment epithelium and outer segment of retinal receptors. 3. Adherent to pigment epithelium and sclera.

B. 1. 70-80 radial . a. Produce aqueous humor, which is low in protein. (1) Metabolic supply for cornea and . (2) Helps maintain intraocular pressure.

b. Angle of filtration (1) drains into scleral venous sinuses - canal of Schlemm. (2) Obstruction leads to and blindness due to increased intraocular pressure on optic nerve = depressed or cupped disc. This collapses the retinal veins leading to retinal edema and additional risk of .

c. Produces zonule fibers that suspend lens = suspensory ligament. Contraction of ciliary muscles (smooth muscle innervated by III nerve) results in decreased tension on the zonular fibers and increasing curvature of the lens for near vision.

C. 1. Continuation of ciliary body. 2. Sphincter M. near margin - parasympathetic via III N. 3. Dilator M. - radial, lateral - sympathetic via superior cervical ganglion. 4. Separates anterior and posterior chambers

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Young, Young, and Tolbert Fig. 14-2

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IV. LENS A. Cells become fibrous, condensed, homogeneous, elongated, lose nuclei. B. Continuous addition of cells at equator. C. Avascular - maintains its own metabolism. D. Capsule – acellular membrane surrounding lens epithelium. E. Contraction of in ciliary body reduces tension on zonular fibers and permits rounding up of lens (=). F. Rigidity of lens increases with age – . G. Opacifies with age - . Replacement lenses can be placed inside the capsule.

V. VITREOUS HUMOR (or behind the lens) A. Collagen (fibrils), hyaluronic acid, wandering cells, 99% water. B. Produced by ciliary processes and retinal glial cells. C. Liquifies as part of aging process and retina can detach. D. “” – aggregations of vitreous material – generally normal but sudden appearance could be a symptom of retinal disease.

Young, Young, and Tolbert Fig. 14-1

01 Globe dental 2011.doc 5 VI. NEUROECTODERMAL LAYER A. Pigment epithelium - outer layer optic cup. 1. Absorbs light, decreases reflection. 2. Phagocytoses discs in outer segments of photoreceptors. 3. Resynthesizes photopigments. 4. Weak junction with retina is site of retinal detachment. B. Retina - inner layer of optic cup. 1. Photoreceptors – Rods (B&W) and Cones (Color). Phototransduction takes place in outer segments of these cells. 2. Bipolar Cells –conduct signal from photoreceptors to inner retina. 3. Ganglion Cells - axons from the optic nerve where impulses originate. 3. Horizontal and amacrine cells - Lateral connections for contrast enhancement. (Synapses located in outer and inner plexiform layers.) 5. Glial Cells (in retina are called Müller Cells) - span the width of the retina. Play an important role in retinal homeostasis of ions and neurotransmitters. Neurectodermal layers

Sclera

Choroid RPE

ONL (rods, cones)

INL (interneurons)

GCL (ganglion cells)

Young, Young, and Tolbert Fig. 14-3

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C. Blood supply. 1. Central retinal – supplies blood to inner layers of retina. 2. Ciliary – supply blood to outer segments of photoreceptors.

01 Globe dental 2011.doc 7 VII. RETINAL LANDMARKS A. Macula lutea - area of acute vision. Fovea - small pit in center of macula. Directly along the visual axis. 1. Cones predominate – color vision. 2. Inner nuclear and ganglion cell layers displaced laterally. 3. No blood vessels or optic nerve fibers internal to photoreceptor layer.

B. (papilla, nerve head), 1.5 mm 1. Ganglion cell axons pierce sclera and leave the globe. 2. Cell layer of retina not present, therefore, there is a "blind spot". 3. The point where the central retinal artery enters and the central retinal vein leaves. 4. Disc is depressed (cupped) with increased intraocular pressure (i.e., glaucoma). 5. Disc bulges ( - choked with increased intracranial pressure (i.e., tumor).

Macula and optic disc

01 Globe dental 2011.doc 8 From Greenberg DA, Aminoff MJ, Simon RP:Clinical Neurology, 2nd ed.

01 Globe dental 2011.doc 9 Fovea cross-section

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VIII. OPTIC NERVE A. Ganglion cell axons pierce sclera at lamina cribrosa, and are myelinated beyond this point. B. Dura and sclera are continuous externally. C. Presence of potential subarachnoid space - papilledema from increased intracranial pressure, which reduces axoplasmic, outflow and produces axonal conduction block and edema. The disc appears to bulge and on testing, the blind spot is enlarged. Axons can atrophy or degenerate >>pallor D. Contains astrocytes and oligodendrocytes (i.e., part of central nervous system). E. Central retinal artery and vein in center. F. Inflammation - seen with multiple sclerosis, drugs, toxins. All produce = an area of depressed vision within the visual field. A can be physiological (blind spot) or pathological.

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