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The RUNX1 Database The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy by Claire C. Homan, Sarah L. King-Smith, David M. Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba Bödör , Alan Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Jude Ftizgibbon, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V. Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Velloso, Benedict Yan, Paul Liu, Lucy A. Godley, Andreas W. Schreiber, Christopher N. Hahn, Hamish S. Scott, and Anna L. Brown. Collaborative Groups: RUNX1 international data sharing consortium (Michael Doubek, Stephen Langabeer, Koneti Rao, Josée Hébert, Lauren M. Bear, Timothy A Graubert, Akiko Shimamura, Peter Ganly, Marc H.G.P. Raaijmakers, Peter J.M. Valk, Paula Heller) Haematologica 2021 [Epub ahead of print] Citation: Claire C. Homan, Sarah L. King-Smith, David M. Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba Bödör , Alan Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Jude Ftizgibbon, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V. Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Velloso, Benedict Yan, Paul Liu, Lucy A. Godley, Andreas W. Schreiber, Christopher N. Hahn, Hamish S. Scott and Anna L. Brown. Collaborative Groups: RUNX1 international data sharing consortium (Michael Doubek, Stephen Langabeer, Koneti Rao, Josée Hébert, Lauren M Bear, Timothy A Graubert, Akiko Shimamura, Peter Ganly, Marc H.G.P. Raaijmakers, Peter J.M. Valk, Paula Heller). The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Haematologica. 2021; 106:xxx doi:10.3324/haematol.2021.278762 Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process. The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Claire C. Homan1,2, Sarah L. King-Smith1,2, David M. Lawrence1,2,3, Peer Arts1,2, Jinghua Feng2,3, James Andrews1,2, Mark Armstrong1,2, Thuong Ha1,2, Julia Dobbins1,2, Michael W. Drazer4, Kai Yu5, Csaba Bödör6, Alan Cantor7, Mario Cazzola8,9, Erin Degelman10, Courtney D. DiNardo°11, , Nicolas Duployez12,13, Remi Favier14, Stefan Fröhling15,16, Jude Fitzgibbon17, Jeffery M. Klco18, Alwin Krämer19, Mineo Kurokawa20, Joanne Lee21 , Luca Malcovati°8,9, Neil V. Morgan22, Georges Natsoulis23, Carolyn Owen10, Keyur P. Patel11, Claude Preudhomme12,13, Hana Raslova24, Hugh Rienhoff23, Tim Ripperger25, Rachael Schulte26, Kiran Tawana27, Elvira Velloso28,29, Benedict Yan21, Paul Liu5, Lucy A. Godley°4, Andreas W. Schreiber2,3,30, Christopher N. Hahn°1,2,31, Hamish S. Scott1,2,30,31, Anna L. Brown1,2,31°*. On behalf of the RUNX1 international data-sharing consortium. 1Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia; 2Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia; 3Australian Cancer Research Foundation (ACRF) Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia; 4Section of Hematology/Oncology, Departments of Medicine and Human Genetics, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL; 5National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; 6 HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary; 7Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; 8Department of Molecular Medicine, University of Pavia, Pavia, Italy; 9Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 10Division of Hematology and Hematological Malignancies, Foothills Medical Centre, Calgary, AB, Canada; 11Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX; 12Laboratory of Hematology, Biology and Pathology Center, Centre Hospitalier Regional Universitaire de Lille, Lille, France; 13Jean-Pierre Aubert Research Center, INSERM, Universitaire de Lille, Lille, France; 14Assistance Publique- Hôpitaux de Paris, Armand Trousseau children's Hospital, Paris, France; 15Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; 16German Cancer Consortium (DKTK), Heidelberg, Germany; 17Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK; 18St Jude Children's Research Hospital, Memphis, Tennessee, United States; 19Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, Heidelberg, Germany; 20Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Japan; 21Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore; 22Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, UK; 23Imago Biosciences, Inc., San Francisco, CA, USA; 24Institut Gustave Roussy, Université Paris Sud, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villejuif, France;25Department of Human Genetics, Hannover Medical School, Hannover, Germany; 26Department of Pediatrics, Division of Pediatric Hematology and Oncology, Monroe Carell Jr. Children’s Hospital, Vanderbilt University Medical Center, Nashville, TN, USA; 27Department of Haematology, Addenbrooke’s Hospital. Cambridge, CB2 0QQ. 28Service of Hematology, Transfusion and Cell Therapy and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31) HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil; 29 Genetics Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil. 30School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia; 31School of Medicine, University of Adelaide, Adelaide, SA, Australia. ° Clinical Genome Resources Variation Myeloid Malignancy Expert Panel committee members *Corresponding author: [email protected] Competing Interests: The authors declare no competing financial interests Acknowledgments: This work is supported by a grant from the RUNX1 Research Program. The authors would also like to thank the RUNX1 Research Program for their support in helping to facilitate the development of the database and fostering collaborations. We also thank the patients and their family members for their willingness to participate in this research and the RUNX1 international data-sharing consortium for their valuable contributions. This project is also proudly supported by funding from the Leukaemia Foundation of Australia, and project grants APP1145278 and APP1164601 from the National Health and Medical Research Council of Australia. This work was produced with the financial and other support of Cancer Council SA's Beat Cancer Project on behalf of its donors and the State Government of South Australia through the Department of Health (PRF 1 Fellowship to H.S.S.). P.A. is supported by a fellowship from The Hospital Research Foundation. Part of this project was undertaken whilst P.A. was holding a Royal Adelaide Hospital Mary Overton Early Career Fellowship. L.M is supported by Associazione Italiana per la Ricerca sul Cancro (AIRC) (Accelerator Award Project 22796; 5x1000 Project 21267; Investigator Grant 2017 Project 20125). L.A.G is supported by the Cancer Research Foundation. KY and PL are supported by the Division of Intramural Research, National Human Genome Research Institute, NIH. T.R. is supported by a grant of the European Hematology Association (EHA) and BMBF MyPred (01GM1911B). CB is supported by EU’s Horizon 2020 Research and Innovation Program under grant agreement No. 739593. The RUNX1 international data-sharing consortium includes all co-authors and others, including Michael Doubek (Masaryk University, Czechia), Stephen Langabeer (St. James’s Hospital, Ireland), Koneti Rao (Sol Sherry Thrombosis Research Center,
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