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TAKEDA TARGETSOFNUP98HOXA9FUSION3DDN 11 Supplemental ZHANG RESPONSETOIKKINHIBITORANDTNFUP 0 2 4 6 8 10 0 SCHUETZ BREASTCANCERDUCTALINVASIVEUP Amino acidtransportacrosstheplasmamembrane Gene GALINDO IMMUNERESPONSETOENTEROTOXIN Proteoglycan syndecan-mediatedsignalingevents or 7 MARTORIATI MDM4TARGETSFETALLIVERUP PASQUALUCCI LYMPHOMABYGCSTAGEUP ICHIBA GRAFTVERSUSHOSTDISEASED7UP RUTELLA RESPONSETOCSF2RBANDIL4DN TRNs, KRIGE RESPONSETOTOSEDOSTAT24HRUP Amino acidandoligopeptideSLCtransporters Alanine, aspartateandglutamatemetabolism Intestinal immunenetworkforIgAproduction BROWNE INTERFERONRESPONSIVEGENES ZHAN MULTIPLEMYELOMACD1VSCD2UP Phosphorylation ofCD3andTCRzetachains response totransforminggrowthfactorbeta CHEN METABOLICSYNDROMNETWORK ELVIDGE HIF1AANDHIF2ATARGETSDN CDF) TCR signalinginnaïveCD8+Tcells LEE DIFFERENTIATINGTLYMPHOCYTE HIF-1-alpha transcriptionfactornetwork LI INDUCEDTTONATURALKILLERUP Cytokine-cytokine receptorinteraction the Integrin familycellsurfaceinteractions Beta1 integrincellsurfaceinteractions IL2 signalingeventsmediatedbyPI3K Alpha9 beta1integrinsignalingevents - VERHAAK GLIOBLASTOMANEURAL PYEON HPVPOSITIVETUMORSUP set single organismalcelladhesion : NAGASHIMA NRG1SIGNALINGUP KRIGE AMINOACIDDEPRIVATION type iinterferonsignalingpathway CXCR4-mediated signalingevents NAGASHIMA EGFSIGNALINGUP ELVIDGE HYPOXIABYDMOGUP T cellreceptorsignalingpathway the Glycolysis andGluconeogenesis myeloid leukocytedifferentiation Cell adhesionmolecules(CAMs) GO, Starch andsucrosemetabolism IL27-mediated signalingevents IL23-mediated signalingevents IL12-mediated signalingevents Interferon alpha/betasignaling response tointerferongamma Chemokine signalingpathway providing Glycolysis /Gluconeogenesis IL2-mediated signalingevents ELVIDGE HIF1ATARGETSDN maximum Jak-STAT signalingpathway TGF BetaSignalingPathway glycogen metabolicprocess brown fatcelldifferentiation LIU PROSTATECANCERDN ONGUSAHA TP53TARGETS . 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KLF10 KLF10 KLF10 KLF10 KLF10 clustered FOXO1 TF FOXO1 FOXO1 FOXO1 FOXO1 for between ZEB1 ZEB1 ZEB1 ZEB1 ZEB1 CIC CIC CIC CIC CIC - RUNX1 RUNX1 RUNX1 RUNX1 RUNX1 Signatures MSigDBPos TF modules AHRR AHRR AHRR AHRR AHRR PathwayCommonsPos MAPP ZBTB32 ZBTB32 ZBTB32 ZBTB32 ZBTB32 PLSCR1 PLSCR1 PLSCR1 PLSCR1 PLSCR1 PLAGL1 PLAGL1 PLAGL1 PLAGL1 PLAGL1 module BHLHE41 BHLHE41 BHLHE41 TRN BHLHE41 BHLHE41 the JDP2 JDP2 JDP2 JDP2 JDP2 and DDIT3 DDIT3 DDIT3 DDIT3 DDIT3 the ETV4 ETV4 ETV4 ETV4 ETV4 BCL11B BCL11B BCL11B BCL11B BCL11B aGOslimPos and STAT2 STAT2 STAT2 MAPPPos STAT2 STAT2 color in KeggPos TF IRF9 IRF9 IRF9 IRF9 IRF9 color IRF7 IRF7 IRF7 IRF7 IRF7 TF’s Th STAT4 STAT4 STAT4 STAT4 STAT4 enrichments Signatures STAT1 STAT1 STAT1 STAT1 STAT1 modules IRF2 IRF2 IRF2 IRF2 IRF2 17 IRF1 IRF1 IRF1 IRF1 IRF1 ChIP+KO+ATAC bar - TRP73 TRP73 TRP73 TRP73 TRP73 coded ZFP365 ZFP365 ZFP365 ZFP365 ZFP365 target biology ZFP750 ZFP750 ZFP750 ZFP750 ZFP750 ZFP385A ZFP385A ZFP385A ZFP385A ZFP385A maximum TRP53 TRP53 TRP53 TRP53 TRP53 ZFP280B ZFP280B ZFP280B ZFP280B ZFP280B IRF4 IRF4 IRF4 IRF4 IRF4 . ERG ERG ERG ERG ERG ZFP367 ZFP367 ZFP367 ZFP367 according ZFP367 We from genes E2F4 E2F4 E2F4 E2F4 E2F4 . are E2F1 E2F1 E2F1 E2F1 E2F1 ZFP960 ZFP960 ZFP960 ZFP960 ZFP960 PHF20 PHF20 PHF20 PHF20 PHF20 compiled SCRT1 SCRT1 SCRT1 SCRT1 SCRT1 MSigDB SP9 SP9 SP9 SP9 SP9 consistent is DPF1 DPF1 DPF1 DPF1 DPF1 KDM5B KDM5B KDM5B KDM5B KDM5B and HIF3A HIF3A HIF3A HIF3A HIF3A 7 HIF1A HIF1A HIF1A HIF1A HIF1A TRN) , C030039L03RIK C030039L03RIK C030039L03RIK C030039L03RIK C030039L03RIK to ANKZF1 ANKZF1 ANKZF1 ANKZF1 ANKZF1 and, PLAGL2 PLAGL2 PLAGL2 PLAGL2 PLAGL2 REL REL REL REL REL gene the Figure S17 . gene NFKB2 NFKB2 NFKB2 NFKB2 NFKB2 For NFKB1 NFKB1 NFKB1 NFKB1 NFKB1 ELF1 ELF1 ELF1 ELF1 ELF1 Figure Figure among DMRT1 DMRT1 DMRT1 DMRT1 DMRT1 for TF CREB1 CREB1 CREB1 CREB1 CREB1 each ATF2 ATF2 ATF2 ATF2 ATF2 sets sets PEG3 PEG3 PEG3 PEG3 PEG3 - the PRRX1 PRRX1 PRRX1 PRRX1 PRRX1 TF HMGA2 HMGA2 HMGA2 HMGA2 HMGA2 ZFP534 ZFP534 ZFP534 ZFP534 ZFP534 HOXB1 HOXB1 HOXB1 HOXB1 HOXB1 RXRA RXRA RXRA RXRA RXRA MYT1L MYT1L MYT1L MYT1L MYT1L S16 0 1 2 3 4 5 6 7 8 9 0 2 4 6 8 10 0 1 2 3 4 5 6 0 1 2 3 4 5 0 1 2 3 4 5 6 7 8 9 10 11.
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